4,156 results match your criteria European Journal of Gynaecological Oncology[Journal]


Sclerosing stromal tumor of the ovary in a perimenopausal woman: a case report.

Authors:
S J Liu W Lv M Shi

Eur J Gynaecol Oncol 2017 ;38(2):326-328

Sclerosing stromal tumor (SST) is a rare ovarian neoplasia deriving from the sex cord stromal tumor, which occurs usually in the sec- ond and third decades of life. However, the authors report a 46-year old multiparous woman who presented with a cystic-solid left pelvic mass, a large amount of ascites, and elevated serum CA-125, all suggesting a malignant tumor. Surgery was performed and final histopathological diagnosis of the specimen was diagnosed with SST. Read More

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Chemotherapy-induced differentiation to cure botryoid rhabdomyosarcoma: a case report and review of the literature.

Eur J Gynaecol Oncol 2017 ;38(2):323-325

Rhabdomyosarcoma (RMS) occurs rarely in adults and constitutes 2-6% of all uterine neoplasms. The authors report the case of a 26-year-old woman diagnosed with botryoid RMS that presented discordant progression results on follow up imaging and cytodifferentiation on pathologic control. This case showed that radiological evaluation could be misleading as the tumor demonstrated chemotherapy-induced differentiation without volume reduction. Read More

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July 2018
3 Reads

Mixed endometrial stromal and smooth muscle tumor of the uterus in a postmenopausal woman: morphologic and immunohistochemical features.

Eur J Gynaecol Oncol 2017 ;38(2):319-322

Mixed endometrial stromal and smooth muscle tumor of the uterus is a rare occurrence, and it is truly challenging to diagnose or dif- ferentiate mesenchymal tumors of the uterine corpus, due to their many overlapping features. In most cases, the gross pathology of mixed endometrial stromal and smooth muscle tumor differs from that of pure endometrial stromal and pure smooth muscle tumors. A 59-year-old postmenopausal woman presented with vaginal spotting, low abdominal pain, and an uterine mass. Read More

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Retroperitoneal primitive neuroectodermal tumor (PNET): case report and review of literature.

Eur J Gynaecol Oncol 2017 ;38(2):314-318

Primitive Neuroectodermal tumor belongs to the family of Ewing's tumor and is characterized by at (11;22) (q24;ql2) or at (21;22) (q22;ql2) translocation. Retroperitoneal primitive neuroectodermal tumor (PNET) are rare, usually affect young adults, and are often diagnosed late. There is no specific characteristics for imaging. Read More

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Advanced stage yolk sac ovarian tumour: clinical approach with cytoreductive surgery upfront.

Eur J Gynaecol Oncol 2017 ;38(2):311-313

The authors report the case of a 21-year-old woman that presented a Pseudo Meigs' syndrome, secondary to a pure endodermal sinus tumour (yolk sac tumour). Fine needle aspiration biopsy was compatible with high-grade carcinoma and the alpha fetoprotein (αFP) was at 13,185 U/ml. Cytoreductive surgery was performed, followed by bleomycin, etoposide, and cisplatin (BEP) chemotherapy. Read More

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July 2018
1 Read

Vulvar and gastric involvement in plasmablastic lymphoma.

Eur J Gynaecol Oncol 2017 ;38(2):308-310

Plasmablastic lymphoma is highly malignant and invasive. It is most commonly found in gastrointestinal tract and is strongly asso- ciated with human immunodeficiency virus (HIV). The authors report a case of a 37-year-old HIV-positive African American woman with a vulvar mass diagnosed as plasmablastic lymphoma. Read More

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July 2018
3 Reads

Endometriotic lesions mimicking advanced ovarian cancer - A case report and a review of the literature.

Eur J Gynaecol Oncol 2017 ;38(2):303-307

Background: Approximately 2-5% of women affected by endometriosis are postmenopausal. The disease may simulate various malignancies. A case of endometriosis in a postmenopausal woman, spreading similarly to ovarian cancer, is reported. Read More

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Cloacogenic adenocarcinoma of the vulva: one new case and literature review.

Eur J Gynaecol Oncol 2017 ;38(2):296-302

Primary adenocarcinoma of the vulva is uncommon, and cloacogenic adenocarcinoma of the vulva is extremely rare. Here the authors report a vulvar neoplasm, arising in continuity with the epidermis, characterized by villoglandular architecture, and mucinous-type ep- ithelium with intestinal differentiation (goblet cells). Histochemistry, immunohistochemistry, and gene mutation analysis revealed a colon-like pattern, except for CK7 expression. Read More

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High cellularity and mitotic activity in a primary ovarian fibro-thecomatous tumor of a young patient: a diagnostic and clinical challenge.

Eur J Gynaecol Oncol 2017 ;38(2):294-295

Purpose ofInvestigation: Solid ovarian tumors represent a clinical challenge, in particular in case of young patients who require a fertility sparing treatment. The authors report a case of hypercellular mitotically active ovarian fibrothecoma in a very young woman, successfully treated with a fertility sparing surgery.

Materials And Methods: A 21-year-old nulliparous woman presented at the present hospital with a 14-cm right ovarian mass, consisting of solid and pseudo-cystic components. Read More

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Rapidly progressing central-type primitive neuroectodermal tumor of the ovary: a case report.

Eur J Gynaecol Oncol 2017 ;38(2):290-293

Primitive neuroectodermal tumors (PNET) belong to a group of highly malignant tumors comprised of small round cells of neu- roectodermal origin. These tumors can be either of peripheral-type (Ewing family tumors/PNET) or central-type. A number of case re- ports have described PNET involving the gynecologic organs and the prognosis is generally poor. Read More

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Two unusual cases: vulvar lipoma - description of the largest case in literature. Developing myoma with the longest pedicle.

Eur J Gynaecol Oncol 2017 ;38(2):286-289

The authors present two cases of benign tumors one located on the outer surface of the vulva, and the second extending beyond the vagina. The first, originating from the right pudendal lip, a lipoma measuring 23 cm in greatest diameter, weighing 6.6 kg, and the second a pedunculated, uterine smooth muscle myoma with a pedicle of 6. Read More

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The role of oxidative stress in premalignant lesions.

Eur J Gynaecol Oncol 2017 ;38(2):282-285

Purpose Of Investigation: The authors aimed to evaluate serum total oxidant status (TOS), total antioxidant status (TAS), and oxida- tive stress index (OSI) in women with abnormal cervical cytology, to determine the association between serum oxidant and antioxidant status of these women, and the progression of abnormal cervical cytology.

Materials And Methods: A total of 75 women enrolled in the study: 20 women with a determination of atypical squamous cells of undetermined significance (ASCUS), 20 women with low squamous intraepithelial lesions (LSIL), 15 women with high squamous intraepithelial lesions (HSIL) and 20 healthy controls. Serum TOS and TAS were determined and OSI was calculated as the indicator of degree of oxidative stress. Read More

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Hypoxia induces autophagy in PA-l ovarian teratoma cells and resistance to growth inhibition and apoptosis by chemotherapeutic agent cis-diamminedichloroplatinum.

Eur J Gynaecol Oncol 2017 ;38(2):277-281

Pathological hypoxia exists in solid tumors and it creates a microenvironment for tumor cells which has a critical and complicated implication for cancer. Hypoxia can also activate autophagy which plays a dual role in cancer. In this study the authors analyzed the effect of hypoxia, the autophagy inhibitor 3-methyladenine (3-MA), cis-diamminedichloroplatinum (CDDP, cisplatin), and any combination of them on PA-l cells (a human ovarian cancer cell line) with a series of assays, focusing on autophagy induction, cell growth inhibition, and cell death by CDDP. Read More

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July 2018
9 Reads

Suppressing stathmin-l can inhibit chkl protein expression and reduce the invasion and tumorigenicity of cervical cancer cells.

Eur J Gynaecol Oncol 2017 ;38(2):271-276

The purpose of this study was to evaluate the effects of stathmin-l on chkl protein expression in cervical cancer cells and the influ- ences on the cells' invasion and tumorigenicity. Suppressed stathmin-l expression in Hela cells and C33A cells by lentiviral vector were utilized. Real time PCR and Western blot were used to examine the expression of chkl. Read More

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Role and timing of second-line therapies for patients with recurrent platinum-resistant ovarian epithelial cancer.

Eur J Gynaecol Oncol 2017 ;38(2):266-270

Objective: To explore the regimens and prognoses of second-line therapies for recurrent platinum-resistant ovarian epithelial cancer (OEC).

Materials And Methods: The clinical profiles and second-line regimens were retrospectively analyzed for 65 recurrent platinum-resistant OEC patients treated at Zhejiang Provincial Tumor Hospital during January 2003 to January 2013. In conjunction with literature reviews, the second-line therapies for platinum-resistant recurrent OEC were discussed. Read More

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Anatomical variations of the obturator veins and their surgical implications.

Eur J Gynaecol Oncol 2017 ;38(2):263-265

Purpose Of Investigation: The obturator veins and their network contribute to major bleeding complications during gynaecologic surgery.

Materials And Methods: The anatomical variations of the obturator veins were studied on 106 patients in which a thorough bilateral pelvic lymphadenectomy was performed.

Results: Symmetrical drainage on right and left sides was found in 75 cases: only in internal iliac vein in 32 cases, both in external iliac vein and internal in 41 cases, and only in external in two cases (so called "pubic vein"). Read More

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Clinical evaluation of MRI in the differential diagnosis between benign and malignant ovarian tumors.

Eur J Gynaecol Oncol 2017 ;38(2):257-262

Ovarian tumors present a special diagnostic challenge when imaging findings cannot be categorized into benign or malignant pathology. Magnetic resonance imaging (MRI) is currently used to evaluate ovarian tumors. The aim of this study was to evaluate the diagnostic performance of MRI in patients with benign or malignant ovarian tumors and enhance its diagnostic accuracy. Read More

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Forkhead box protein 3 (FoxP3) mRNA as a diagnostic marker in ovarian tumors: a pilot study.

Eur J Gynaecol Oncol 2017 ;38(2):251-256

Purpose: To assess the diagnostic performance of forkhead box protein 3 (FoxP3) mRNA in ovarian tumors.

Materials And Methods: Using quantitative real time reverse transcription PCR (q-RT-PCR), FoxP3 mRNA level was measured in fresh frozen ovarian tumors and its diagnostic performance was compared to those of preoperative serum CA 125 and risk of malignancy index (RMI).

Results: FoxP3 mRNA was differentially expressed in the malignant (n = 25) and benign (n = 25) groups, yet without statistically significant differences; positivity rate: 15/25 vs. Read More

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Overexpressed LEDGF is a novel biomarker of poor prognosis in patients with cervical cancer.

Eur J Gynaecol Oncol 2017 ;38(2):245-250

Lens epithelium-derived growth factor (LEDFG) can prevent cells apoptosis by activating stress proteins and anti-apoptotic protein, which are involved in the development of a variety of malignancies as some studies have shown. However, little is known about the role of LEDGF in cervical cancer. In this study, the authors collected 95 cases of the cervical cancer tissue samples and its matching tissue adjacent to carcinoma diagnosed by the Department of Pathology. Read More

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July 2018
3 Reads

Prevalence of high risk human papillomavirus (HPV) infection and abnormal cervical cytology and knowledge about HPV vaccine in Eastern Turkey.

Eur J Gynaecol Oncol 2017 ;38(2):241-244

Purpose Of Investigation: The aim of the present study was to gather data on the high risk human papillomavirus (HPV) frequency and the distribution of HIPV types in Eastern Turkey in relation to cervical cytology and to assess the knowledge about cervical cancer, HPV, and vaccination.

Materials And Methods: The study population included 1,000 women aged between 20-65 years who attended the outpatients clinics of Department of Obstetrics and Gynecology of the Medical School of Yuzuncu Yil University Hospital.

Results: The overall prevalence of high risk HPV-DNA was 2. Read More

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Inhibitory effects of miR-101 overexpression on cervical cancer SiHa cells.

Authors:
H Liu J Zhao J Lv

Eur J Gynaecol Oncol 2017 ;38(2):236-240

Purpose Of Investigation: microRNAs (miRNAs), which can regulate cell biological behaviors such as proliferation and apoptosis as oncogenes or anti-oncogenes, are closely associated with cancer onset and progression. The aim of this study was to detect the expres- sion changes of miR-101 in cervical cancer tissues and the effects on the biological functions of cervical cancer SiHa cells.

Materials And Methods: Through transient transfection of SiHa cells with mature miR-101 sequences, the effects on apoptosis, proliferation, and cell cycle were evaluated by real-time PCR, CCK-8 assay, and flow cytometry. Read More

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Lymph node involvement in clinically apparent early ovarian cancer: a prospective study.

Eur J Gynaecol Oncol 2017 ;38(2):232-235

Purpose: The objective of this study was to identify the lymph node involvement in apparently early ovarian cancer (OC) Materials and Methods: Patients with clinically apparent early OC who underwent staging surgery between August 2012 and August 2015 were prospectively identified. Patients' characteristics and tumor histopathology were evaluated.

Results: Twenty consecutive patients were operated for grossly apparent early ovarian carcinoma. Read More

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Central nervous system metastatic epithelial ovarian cancer. Clinical parameters and prognostic factors: a multicenter study of Anatolian Society of Medical Oncology.

Eur J Gynaecol Oncol 2017 ;38(2):227-231

Central nervous system (CNS) metastasis is a rare event in the course of late stage epithelial ovarian cancer (EOC); however its incidence is increasing in parallel with prolonged survival of patients.

Objective: The authors assessed the clinical parameters and potential prognostic features in patients with CNS metastatic disease.

Materials And Methods: Clinical data of the 33 patients from the participating centers were retrospectively collected and analyzed. Read More

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Direct uterine sampling using the SAP-l sampler device to detect endometrial lesions during histopathological examination.

Eur J Gynaecol Oncol 2017 ;38(2):221-226

Aims: To evaluate the sampling adequacy and diagnostic accuracy of the endometrial SAP-l sampling device in detecting endometrial lesions based on histopathological examination.

Materials And Methods: In total, 182 patients who required an endometrial biopsy were enrolled in this study. All of the patients underwent endometrial biopsies with the SAP-l sampler prior to hysteroscopy (169/182) or dilatation and curettage (D&C) (13/182). Read More

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July 2018
1 Read

Ovarian Sertoli-Leydig cell tumors: a single institution experience and review of the literature.

Eur J Gynaecol Oncol 2017 ;38(2):214-220

Purpose ofinvestigation: Sertoli-Leydig cell tumors (SLCTs) of the ovary are rare, usually presenting as virilization in women in their second to third decade of life. Less than 10% of patients are older than age 50. The authors present a series of cases of SCLT managed at their institution. Read More

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Application of combined intraperitoneal and intravenous neoadjuvant chemotherapy in senile patients with advanced ovarian cancer and massive ascites.

Eur J Gynaecol Oncol 2017 ;38(2):209-213

Objective: The aim of this study was to explore the effects of neoadjuvant chemotherapy in senile patients with advanced ovarian can- cer and ascites.

Materials And Methods: One hundred eight senile patients with advanced ovarian cancer and ascites were randomly di- vided into two groups: experimental and control groups. Patients in the experimental group were treated with two courses of intraperitoneal combined with intravenous neoadjuvant chemotherapy, followed by cytoreductive surgery, and six courses of intravenous chemotherapy, while the patients in the control group only received cytoreductive surgery and six to eight courses of intravenous chemotherapy. Read More

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Immunohistochemical c-kit expression in uterine serous carcinoma tissue.

Eur J Gynaecol Oncol 2017 ;38(2):207-208

Aim: Uterine serous carcinoma (USC) is an aggressive tumor that represents only 10% of endometrial cancer cases but accounts for a disproportionate number of deaths due to uterine cancer. Advances in the development of specific c-kit receptor-targeted drugs have promoted its potential therapeutic application as a target in tumor-related diseases. The aim of the present study was to evaluate imunohistochemical expression of c-kit in USC tissue in order to assess whether positive cases can be candidates for targeted therapy. Read More

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Defective expression of polarity protein Par3 promotes cervical tumorigenesis and metastasis.

Eur J Gynaecol Oncol 2017 ;38(2):199-206

Objectives: The aim of this study was to investigate whether the partition-defective 3 protein (Par3) regulates cervical carcinoma growth and metastasis.

Materials And Methods: Immunohistochemistry (IHC) was used to analyze the expression of Par3 protein in samples from 89 cervical squamous cell carcinoma (CSCC) patients among Uyghur women. The specific short hairpin (shRNA) vector as well as eu- karyotic expression vector of PARD3 was transfected into SiHa cell lines. Read More

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Complications following type 3 excision by needle excision of the transformation zone: a case series report.

Eur J Gynaecol Oncol 2017 ;38(2):196-198

Objective: To determine short-term complications and related risk factors following needle excision of the transformation zone (NETZ).

Materials And Methods: A case series of 105 women with NETZ for cervical pathology between 2006-2013 in a single center.

Results: The overall complication rate was 22. Read More

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Expression of IncRNA UCA1 in ovarian cancer and its clinical significance.

Eur J Gynaecol Oncol 2017 ;38(2):191-195

Objectives: To explore the expression and clinical significance of IncRNA-UCA1 in ovarian cancer.

Materials And Methods: The ex- pression of IncRNA-UCA1 in 26 ovarian cancer tissue and 16 normal and benign ovarian tissue were detected using qRT-PCR method, and the correlation of expression level with clinicopathological features were analyzed.

Results: Higher lncRNA-UCA1 expression level were detected in ovarian cancer tissue than those in normal ovarian tissue (p < 0. Read More

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Correlation between the body mass index of patients with breast cancer before and after chemotherapy.

Eur J Gynaecol Oncol 2017 ;38(2):187-190

The objective of this work was to show how the influence of the microenvironment in tumor cells and consequently the onset and tumor progression is becoming increasingly more evident. Cancer is the second leading cause of death in the developed world, surpassed only by heart disease and obesity, and is increasingly recognised as an oncogenic factor in the genesis of this tumor. Inflammatory me- diators related to obesity are suspected to play a role in oncogenic modification of substrates metabolism of nutrients, most patients diagnosed with breast cancer underwent chemotherapy treatment, and this may be an aggravating factor of obesity. Read More

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Automated breast volume scanner (ABVS) in breast cancer - a review.

Eur J Gynaecol Oncol 2017 ;38(2):184-186

The early detection of breast cancer is essential for its timely diagnosis and treatment. Many imaging modalities are continually being developed to screen and diagnose breast cancer at an early stage. Especially, ultrasound (US) is one of useful diagnostic tools to dis- tinguish benign from malignant masses of the breast. Read More

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Role of cancer stem cells and microRNA in resistance to chemotherapy in patients with ovarian cancer.

Eur J Gynaecol Oncol 2017 ;38(2):181-183

Despite the introduction of "the golden standard" in chemotherapy for ovarian cancer (taxanes/platinum), a relapse of the disease is noted in 80% of women treated in this manner. Studies on ovarian cancer stem cells (CSCs) and attempts at treatment using salinomycin, isolated from Streptonzyces albus and endotoxin of Clostridium peifringens, are promising, in particular because CSC markers have been identified. Resistence of ovarian cancer cells to paclitaxel and cisplatin is associated with a reduced expression of miR-30c, miR-130, and miR335, which results in activation of M-CSF, the known factor of resistance to cytostatic drugs. Read More

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July 2018
11 Reads

Multidisciplinary management of advanced ovarian cancer for an optimal therapeutic strategy.

Eur J Gynaecol Oncol 2017 ;38(2):175-180

The management of advanced ovarian cancer generally requires specialist multidisciplinary teamwork to achieve optimum outcomes. Preoperative computed tomography scans are the imaging modality of choice in determining the extent of disease and aiding in surgical planning. Histological classification is crucial to define various subtypes with their different behaviour and prognosis and to plan the best therapeutic strategy. Read More

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Intensity modulated radiotherapy and brachytherapy for a cervical cancer after renal transplantation.

Authors:
L Yang X Zhang X Lv H Yu

Eur J Gynaecol Oncol 2017 ;38(1):162-165

Radiotherapy and surgery are important radical treatment options for cervical cancer, but the presence of a pelvic kidney complicates the situation. Fine radiation technique can help avoiding side effects. Radiation to the modified pelvis using intensity modulated radiotherapy (IMRT) followed by brachytherapy, while avoiding the renal allograft is technically feasible which ensures adequate target volume and reduces side effects. Read More

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June 2018
1 Read

Non-diethylstilbestrol exposed vaginal adenocarcinoma in young patients associated with unilateral renal agenesis: two case reports and literature review.

Eur J Gynaecol Oncol 2017 ;38(1):157-161

Background: Adenocarcinoma, accounts for up to 14% of all vaginal cancer. In young patients, common histological feature is clear cell adenocarcinoma (CCA) while mesonephric adenocarcinoma (MA) is very rare. The authors report two patients in their early twenties with unilateral renal agenesis and vaginal adenocarcinoma not exposed to diethylstilbestrol (DES). Read More

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June 2018
7 Reads

Seminoma leading to detection of testicular feminization syndrome: a case report.

Eur J Gynaecol Oncol 2017 ;38(1):153-156

The authors here report a 54-year-old (gravida 0, para 0), who claimed to have had her menarche at age 13 and menopause at 52 years. Two months prior to presentation, the subject first noticed a hard but elastic fist-sized mass in the left inguinal region that gradually grew, causing pressure-related pain. Although the external genitalia appeared female, the vagina was short and blind-ending, and no uterus or ovaries were identified on transvaginal ultrasound. Read More

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June 2018
5 Reads

Retroperitoneal leiomyosarcoma: a case report.

Eur J Gynaecol Oncol 2017 ;38(1):150-152

Retroperitoneal leiomyosarcoma is a relatively rare and aggressive tumor. Because of its rarity, it is difficult to arrive at a definite diagnosis preoperatively and to design an effective strategy. Here the authors report a case of peritoneal leiomyosarcoma in which diagnosis was difficult because the clinical course resembled that of ovarian cancer. Read More

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June 2018
1 Read

Ovarian gastrointestinal stromal tumor: does this diagnosis exist?.

Eur J Gynaecol Oncol 2017 ;38(1):147-149

Gastrointestinal stromal tumors (GISTs) are rare gastrointestinal (GI ) tract tumors. Those tumors rarely arise extra intestinally; within omentum, mesentery, and rarely uterus. The authors report a case of myxoid variant of GIST arising in the ovary with no evidence of a primary tumor in the GI tract. Read More

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June 2018
1 Read

Robot-assisted laparoscopic adenomyomectomy of adenomyotic nodule implanted in the uterine endometrium manifesting as endometrial cancer: a case report and literature review.

Eur J Gynaecol Oncol 2017 ;38(1):143-146

Thickened uterine endometrium with abnormal uterine bleeding highly suggests endometrial hyperplasia or endometrial carcinoma. A case of 35-year-old nulliparous woman came to our department with endometrial mass manifesting as endometrial cancer. Transrectal ultrasonography and magnetic resonance imaging (MRI) showed an 8x6 cm multicystic, ill-defined mass compacted at the uterine endometrium, the anterior wall of the uterus, and 3x3 cm heterogenous mass at the left adnexa. Read More

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June 2018
3 Reads

Squamous cell carcinoma arising from teratoma of the ovary: magnetic resonance, computed tomography, and pathological findings.

Eur J Gynaecol Oncol 2017 ;38(1):139-142

In the present case report, the authors investigated the clinicopathological characteristics of squamous cell carcinoma (SCC) arising from teratoma of the ovary and intended to report their clinical experience. Malignant transformation of ovarian teratoma is a quite rare condition with SCC observed to be the most common form of transformation. The present case was a 43-year-old female patient and her clinical presentation was abdominal pain, abdominal distension, and abdominal mass sensation. Read More

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June 2018
1 Read

Effective therapeutic strategy for massive retroperitoneal hematoma after conization: arterial embolization and pigtail catheter insertion.

Eur J Gynaecol Oncol 2017 ;38(1):135-138

The loop electrosurgical excision procedure (LEEP) is commonly used to remove cervical intraepithelial neoplasia (CIN) because of its safety profile and likelihood of fewer complications. The authors report a rare case of massive retroperitoneal bleeding combined with hypovolemic shock after LEEP conization. Vessel injury was detected by angiographic computed tomography (CT) and embolization of the uterine artery was successfully performed to achieve hemostasis by an intervention radiologist. Read More

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June 2018
2 Reads

Tertiary cytoreduction for recurrent endometrial cancer.

Eur J Gynaecol Oncol 2017 ;38(1):132-134

This paper reviews the surgical approach experiences in endometrial cancer recurrence and presents for the first time data on the surgical management of endometrial cancer patients at the time of their second recurrence. Surgery could represent a pivotal role in selected cases of recurrent endometrial cancer, offering long-term complete remissions and a survival advantage. Read More

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June 2018
1 Read

Abdominal radical trachelectomy (ART) performed during pregnancy: a case report.

Eur J Gynaecol Oncol 2017 ;38(1):129-131

Purpose Of Investigation: Cervical cancer is one of the most frequent malignant diseases diagnosed during pregnancy. Abdominal or vaginal radical trachelectomies are fertility-preserving alternatives to radical hysterectomy for young women with early-stage cervical cancer that can be performed during ongoing pregnancy.

Material And Methods: The authors report a pregnancy complicated by cervical cancer treated by abdominal radical trachelectomy (ART) at 16-17 gestational weeks with preservation of the concurrent pregnancy. Read More

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June 2018
1 Read

A case of melanocytic cervical adenosquamous carcinoma complicated with Cushing's syndrome.

Eur J Gynaecol Oncol 2017 ;38(1):126-128

Background: To date, cervical carcinoma complicated with Cushing's syndrome were all diagnosed as small cell carcinoma histo- logically, but not adenosquamous carcinoma. Here the authors present the diagnosis, management, and prognosis of a case of melanocytic cervical adenosquamous carcinoma complicated with Cushing's syndrome.

Case: A 28-year-old woman was admitted with the chief complaint of post-coital bleeding for one month. Read More

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June 2018
1 Read

Surgical removal of an isolated femoral metastasis of uterine cervical squamous cell carcinoma: a case report and review of the literature.

Eur J Gynaecol Oncol 2017 ;38(1):122-125

A bone metastasis from uterine cervical cancer normally indicates short life expectancy. Resection of the lesion is therefore palliative. The authors consider herein whether surgical resection can promote disease control while improving quality of life. Read More

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June 2018
1 Read

Benign metastasizing leiomyoma of bone and lung in postmenopausal women: two rare case reports and review of the literature.

Eur J Gynaecol Oncol 2017 ;38(1):118-121

Benign metastasizing leiomyoma (BML) is a rare disease that mostly occurs in women of reproductive age. Patients usually have a history of uterine leiomyoma and/or myomectomy. Although lung is the most common site of metastasis, bone involvement is rarely occurred. Read More

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June 2018
1 Read

Treosulfan for advanced breast cancer in a heavily pre-treated patient - a case report.

Eur J Gynaecol Oncol 2017 ;38(1):115-117

Background: Treatment of metastatic breast cancer experienced significant improvement in the past decades by introduction of highly effective therapies, but survival still remains poor. Nonetheless, in some patients, long-term survival can be achieved by sequent endocrine and chemotherapy treatment, although toxicity and resistance eventually occur, until no further suitable and approved therapies remain. If further therapy is needed, therapist may be forced to consider treatients which are promising but not approved, such as the alkylating agent treosulfan, which is approved for the treatment of ovarian cancer only. Read More

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June 2018
1 Read

Sternocleidomastoid muscle metastasis of breast cancer: case report.

Eur J Gynaecol Oncol 2017 ;38(1):113-114

The authors report a case of 84-year-old women, with dysphagia to liquids and solid foods, and with infiltration of right stemocleidomastoid muscle that compressed the upper third of the esophagus to the thoracic hull. The biopsy of sternocleidomastoid muscle permitted the diagnosis of metastatic breast cancer relapse after 22 years. Read More

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June 2018
5 Reads

Microarray gene expression profiling for identifying different responses to radiotherapy and chemoradiotherapy in patients with cervical cancer.

Eur J Gynaecol Oncol 2017 ;38(1):106-112

Purpose: Cervical cancer, which is treated by radiotherapy (RT) and chemoradiotherapy (CRT), has high morbidity and mortality in women. This study aimed to identify differences in gene response to CRT and RT.

Materials And Methods: GSE3578 was downloaded from Gene Expression Omnibus including specimens from 20 RT-treated patients and 19 CRT-treated patients. Read More

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June 2018
1 Read