24 results match your criteria European Journal of Gastroenterology & Hepatology[Journal]

  • Page 1 of 1

Endoscopic diagnosis and treatment of esophageal adenocarcinoma: introduction of Japan Esophageal Society classification of Barrett's esophagus.

J Gastroenterol 2019 Jan 30;54(1):1-9. Epub 2018 Jun 30.

Department of Endoscopy, Saku Central Hospital Advanced Care Center, Saku, Japan.

Endoscopic surveillance of Barrett's esophagus has become a foundation of the management of esophageal adenocarcinoma (EAC). Surveillance for Barrett's esophagus commonly involves periodic upper endoscopy with biopsies of suspicious areas and random four-quadrant biopsies. However, targeted biopsies using narrow-band imaging can detect more dysplastic areas and thus reduce the number of biopsies required. Read More

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http://dx.doi.org/10.1007/s00535-018-1491-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314977PMC
January 2019
3 Reads

Utilizing biomarkers in colorectal cancer: an interview with Ajay Goel.

Authors:
Ajay Goel

Future Oncol 2017 Dec 23;13(28):2511-2514. Epub 2017 Nov 23.

Center for Gastrointestinal Research; Center for Translational Genomics and Oncology, Baylor Scott & White Research Institute, Charles A Sammons Cancer Center, Baylor University Medical Center, Dallas, TX, USA.

Ajay Goel speaks to Rachel Jenkins, Commissioning Editor. Ajay Goel, PhD, is a Professor and Director, Center for Gastrointestinal Research, and Director, Center for Translational Genomics and Oncology, at the Baylor Scott & White Research Institute, Baylor University Medical Center in Dallas, Texas. Dr Goel has spent more than 20 years researching cancer and has been the lead author or contributor to over 240 scientific articles published in peer-reviewed international journals and several book chapters. Read More

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http://dx.doi.org/10.2217/fon-2017-0495DOI Listing
December 2017
7 Reads

Exploring liver physiology, pathology, TGF-β, EMT, stemness and new developments in liver cancer.

Authors:
Isabel Fabregat

Hepat Oncol 2017 Jan 6;4(1):9-13. Epub 2017 Jul 6.

Bellvitge Biomedical Research Institute (IDIBELL), Gran Vía de L'Hospitalet, 199. 08908 L'Hospitalet, Barcelona, Spain.

Isabel Fabregat, PhD, is Senior Investigator, Head of the group "TGF-β and cancer", at the Bellvitge Biomedical Research Institute (IDIBELL) and Associate Professor in the School of Medicine and Health Sciences at the University of Barcelona. She is the President of the Spanish Society for Cell Biology since 2011, she was member of the Executive Board of the Spanish Branch of the European Tissue Culture Society and she is currently member of the Spanish Society for the Study of the Liver, and the International Liver Cancer Association, among others. The current research line of her laboratory focuses on the dissection of the molecular mechanisms induced by TGF-β in liver cells that can explain its different, and sometimes opposite, functions in liver pathologies, in particular fibrosis and hepatocarcinogenesis. Read More

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http://dx.doi.org/10.2217/hep-2017-0007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095327PMC
January 2017
2 Reads

Heterogeneity in endoscopic treatment of Crohn's disease-associated strictures: An international inflammatory bowel disease specialist survey.

J Gastroenterol 2016 Oct 30;51(10):939-48. Epub 2016 Jan 30.

Department of Gastroenterology, Hepatology & Nutrition, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.

Background: Crohn's disease (CD) is frequently complicated by intestinal strictures, which are commonly treated by endoscopic balloon dilation (EBD). However, available data on this area of treatment is limited. The aim of this study was to depict the heterogeneity of endoscopic management of CD-associated strictures among international CD specialists to identify common treatment standards. Read More

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http://dx.doi.org/10.1007/s00535-016-1172-6DOI Listing
October 2016
7 Reads

Detection of palisade vessels as a landmark for Barrett's esophagus in a Western population.

J Gastroenterol 2016 Jul 4;51(7):682-90. Epub 2015 Nov 4.

Department of Gastroenterology and Hepatology, St Antonius Hospital, Koekoekslaan 1, 3430 EM, Nieuwegein, The Netherlands.

Background: In Japan, palisade vessels (PV) are used to distinguish the esophagogastric junction (EGJ). Elsewhere, the EGJ is defined by the upper end of the gastric folds (GF) and PV are considered difficult to detect. This study evaluated the detection rate of PV in Western patients with Barrett's esophagus (BE) using white light imaging (WLI) and narrow band imaging (NBI), and quantified any discordance between Western and Japanese criteria for the EGJ. Read More

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http://dx.doi.org/10.1007/s00535-015-1136-2DOI Listing
July 2016
12 Reads

Genetic characteristics of inflammatory bowel disease in a Japanese population.

J Gastroenterol 2016 Jul 28;51(7):672-81. Epub 2015 Oct 28.

Center for Integrative Medical Sciences, RIKEN Yokohama Institute, 1-7-22 Suehiro-cho, Tsurumi, Yokohama, Kanagawa, 230-0045, Japan.

Background: Crohn's disease (CD) and ulcerative colitis (UC) are two major forms of inflammatory bowel disease (IBD). Meta-analyses of genome-wide association studies (GWAS) have identified 163 susceptibility loci for IBD among European populations; however, there is limited information for IBD susceptibility in a Japanese population.

Methods: We performed a GWAS using imputed genotypes of 743 IBD patients (372 with CD and 371 with UC) and 3321 controls. Read More

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http://dx.doi.org/10.1007/s00535-015-1135-3DOI Listing
July 2016
16 Reads

Meta-analysis: the effect of interferon on development of hepatocellular carcinoma in patients with chronic hepatitis B virus infection.

J Gastroenterol 2009 25;44(5):470-5. Epub 2009 Mar 25.

Department of Molecular Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.

Purpose: In patients chronically infected with hepatitis B virus, interferon has been used for the purpose of viral suppression by loss of hepatitis B e antigen (HBeAg) with or without seroconversion to antibody to HBeAg (anti-HBe). However, discussion about the effect of interferon on the development of hepatocellular carcinoma (HCC) has been controversial.

Methods: We conducted a meta-analysis of published studies. Read More

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http://link.springer.com/10.1007/s00535-009-0024-z
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http://dx.doi.org/10.1007/s00535-009-0024-zDOI Listing
July 2009
3 Reads

Squamous intraepithelial neoplasia of the esophagus: past, present, and future.

J Gastroenterol 2009 13;44(2):103-12. Epub 2009 Feb 13.

Department of Pathology, Saitama Medical University International Medical Center, 1397-1 Yamane, Hidaka 350-1298, Japan.

With regard to the esophagus, the term "squamous dysplasia" has been used in European countries, the United States, and China, while its use is controversial in Japan. Recently, "low-grade intraepithelial neoplasia" and "high-grade intraepithelial neoplasia" have been used as inclusive terms for dysplasia and carcinoma in situ in the World Health Organization classification. Endoscopically, it is often difficult to identify squamous intraepithelial neoplasia by conventional endoscopy, but application of iodine is useful for the diagnosis of such a lesion. Read More

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http://dx.doi.org/10.1007/s00535-008-2298-yDOI Listing
April 2009
2 Reads

Thiopurine S-methyltransferase and inosine triphosphate pyrophosphohydrolase genes in Japanese patients with inflammatory bowel disease in whom adverse drug reactions were induced by azathioprine/6-mercaptopurine treatment.

J Gastroenterol 2009 13;44(3):197-203. Epub 2009 Feb 13.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine (Kashiwa Hospital), 163-1 Kashiwa-shita, Kashiwa, Chiba, 277-8567, Japan.

Background: The main cause of azathioprine (AZA)/6-mercaptopurine (6MP)-induced adverse reactions is a reduction in the activities of the metabolizing enzymes thiopurine S-methyltransferase (TPMT) and inosine triphosphate pyrophosphohydrolase (ITPA). Adverse reactions develop at a high frequency in Japanese patients at half the dose required for European and American patients; however, the association with TPMT and ITPA gene polymorphisms in Japanese has not been fully investigated.

Methods: Gene mutations of TPMT and ITPA, the major AZA/6-MP -metabolizing enzymes, were investigated retrospectively in 16 Japanese patients with inflammatory bowel disease (IBD) in whom AZA/6MP treatment induced adverse reactions. Read More

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http://dx.doi.org/10.1007/s00535-008-2307-1DOI Listing
June 2009
2 Reads

Heparanase-2 and syndecan-1 in colon cancer: the ugly ducklings or the beautiful swans?

Eur J Gastroenterol Hepatol 2008 Aug;20(8):716-8

Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Syndecan expression, or the lack thereof by tumor cells, has been associated with poor prognosis in several types of cancer, including colorectal cancer. Syndecan is a heparan sulfate proteoglycan involved in tumor adhesion, invasion, and metastasis. In addition, the expression of the enzyme heparanase by cancer cells correlates with malignant transformation and metastasis. Read More

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http://dx.doi.org/10.1097/MEG.0b013e3282fc2660DOI Listing
August 2008
2 Reads

Variations of author origins in World Journal of Gastroenterology during 2001-2007.

World J Gastroenterol 2008 May;14(19):3108-11

Library of Shengjing Hospital, China Medical University, Liaoning Province, China.

Aim: To discuss the variations and distributions of authors who published their papers in World Journal of Gastroenterology (WJG) during 2001-2007 and evaluate the development of WJG and gastroenterology core journals in recent years by comparing the contributions of the authors.

Methods: WJG articles published in 2001-2007 were searched from MEDLINE database (by ISI Web of Knowledge). The variations (cooperation degree, cooperation rate) and distributions of the first authors were analyzed with bibliometric methods. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712188PMC
May 2008
2 Reads

Nonalcoholic fatty liver disease in Japanese patients with severe obesity who received laparoscopic Roux-en-Y gastric bypass surgery (LRYGB) in comparison to non-Japanese patients.

J Gastroenterol 2008 24;43(1):86-92. Epub 2008 Feb 24.

Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, Maebashi, 371-8511, Japan.

Background: The number of patients with morbid obesity is increasing worldwide. However, the prevalence of morbid obesity is still low in Japan, and therefore few systematic investigations of liver dysfunction in this population have so far been carried out. This study aimed to investigate the clinical characteristics in severe obese Japanese patients undergoing laparoscopic Roux-en-Y gastric bypass surgery (LRYGB). Read More

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http://link.springer.com/10.1007/s00535-007-2130-0
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http://dx.doi.org/10.1007/s00535-007-2130-0DOI Listing
May 2008
19 Reads

Small bowel obstruction caused by secondary tumors.

Surg Oncol 2006 Jul 14;15(1):29-32. Epub 2006 Aug 14.

Institute of Oncology, Kaplan Medical Center, Rehovot, Israel.

Small bowel obstruction in an oncology patient is a common and serious medical problem which is associated with diagnostic as well as therapeutic dilemmas. While the condition is most commonly caused by postoperative adhesions and peritoneal carcinomatosis, other causes have been reported [Cormier WJ, Gaffey TA, Welch JM, et al. Linitis plastica caused by metastatic lobular carcinoma of the breast. Read More

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http://dx.doi.org/10.1016/j.suronc.2006.05.004DOI Listing
July 2006
8 Reads

Late toxicity in complete response cases after definitive chemoradiotherapy for esophageal squamous cell carcinoma.

J Gastroenterol 2006 May;41(5):425-32

Second Department of Internal Medicine, Showa University School of Medicine, Shinagawa-ku, Tokyo, Japan.

Background: We retrospectively investigated long-term toxicity after concurrent chemoradiotherapy (CRT) for patients with esophageal squamous cell carcinoma (ESCC).

Methods: Concurrent chemoradiotherapy was performed in 110 patients with T1 to T4 disease containing M1 lymph node (LYM) disease. Chemotherapy consisted of protracted infusion of 5-fluorouracil 400 mg/m(2) per 24 h on days 1 to 5 and 8 to 12, combined with 2-h infusion of cisplatin 40 mg/m(2) on days 1 and 8. Read More

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http://link.springer.com/content/pdf/10.1007/s00535-006-1771
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http://link.springer.com/10.1007/s00535-006-1771-8
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http://dx.doi.org/10.1007/s00535-006-1771-8DOI Listing
May 2006
17 Reads

New pieces of the pathogenetic mosaic in inflammatory bowel disease.

Eur J Gastroenterol Hepatol 2006 Feb;18(2):123-4

Institute of Pathology, Klinikum Bayreuth, Bayreuth, Germany.

Ulcerative colitis (UC) is a lifelong disease. Patients with UC have an approximately 20% risk of developing colorectal cancer. The risk of neoplasia increases with the duration of the disease. Read More

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February 2006
2 Reads

Infection with hepatitis B virus genotype A in Tokyo, Japan during 1976 through 2001.

J Gastroenterol 2004 Sep;39(9):844-50

Research Institute for Hepatology, Toranomon Hospital, 1-3-1 Kajigaya, Takatsu-ku, 213-8587 Kawasaki, Japan.

Background: Because genotype A of hepatitis B virus (HBV) is not indigenous, there have been only few data on infection with it in Japan.

Methods: We examined clinical and virological features of the 66 Japanese patients who admitted Toranomon Hospital in Tokyo, Japan, between 1976 and 2001, who were found to have HBV/A infection. HBV genotype A was classified into subtype A (European type) and A' (South African type) by phylogenetic analysis of the preS1 and preS2 regions, and the S gene sequences. Read More

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http://dx.doi.org/10.1007/s00535-004-1400-3DOI Listing
September 2004
4 Reads

Intra-epithelial T cells in coeliac disease.

Eur J Gastroenterol Hepatol 2004 Oct;16(10):957-8

Department of Medicine, Institute of Clinical Science, Royal Victoria Hospital, Belfast, UK.

Coeliac disease is an enteropathy associated with dietary gluten which occurs in individuals with a genetic predisposition. The pathogenesis remains obscure although it is clear that only certain parts of the gliadin molecule are toxic and there is considerable evidence of immunological activity, including antibody production. In this issue of European Journal of Gastroenterology and Hepatology Carton et al. Read More

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October 2004
3 Reads

Endoscopic treatment of gastro-oesophageal reflux disease: the new kid on the block.

Scand J Gastroenterol Suppl 2003 (239):29-33

Dept. of' Gastroenterology and Hepatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Background: Gastro-oesophageal reflux disease is a common disease entity with approximately 7% of European adults experiencing significant daily symptoms. The impact of reflux disease on the quality of life is considerable. Complications of reflux disease include oesophagitis, stricture, Barrett's and pulmonary symptoms. Read More

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May 2004
3 Reads

Auxiliary partial orthotopic liver transplantation (APOLT) in the treatment of acute liver failure.

J Gastroenterol 2002 ;37 Suppl 13:88-91

Centre de Chirurgie Viscérale et de Transplantation, Hĵpital Universitaire de Hautepierre, Strasbourg, France.

Background: Auxiliary partial orthotopic liver transplantation (APOLT) has been developed in order to benefit from the efficacy of orthotopic liver transplantation (OLT) in the treatment of fulminant hepatic failure (FHF), but to avoid the negative counterpart of OLT which is to eliminate the possibility of native liver (NL) regeneration and which consequently implies a life-long immunosuppression.

Methods: In our institution we performed 16 consecutive APOLTs in 15 patients between October 1992 and December 1999. Patients' mean age was 30 years (range 0. Read More

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January 2003
4 Reads

Secondary prophylaxis of oesophageal variceal haemorrhage: a role for transjugular intrahepatic portosystemic shunt?

Eur J Gastroenterol Hepatol 2002 Jun;14(6):591-3

The Institute of Liver Studies, King's College Hospital, Denmark Hill, London, UK.

Cirrhotic patients who survive an episode of acute variceal haemorrhage are at high risk of recurrent bleeding. Many treatments have been found to be effective at preventing rebleeding, including drug therapy, endoscopic treatments and transjugular intrahepatic portosystemic stunt (TIPS). In this issue of European Journal of Gastroenterology & Hepatology, Jalan et al. Read More

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June 2002
5 Reads

Does detection of K-ras mutations in pancreatic juice influence clinical decision making?

Eur J Gastroenterol Hepatol 2001 Oct;13(10):1141-2

Centre for Digestive Diseases, The General Infirmary at Leeds, Leeds, UK.

The majority of patients with pancreatic cancer harbour mutations in the K-ras gene. This oncogene may be detected in material obtained at endoscopic retrograde cholangiopancreatography (ERCP), such as bile and pancreatic juice. Since a formal tissue diagnosis may be difficult to establish in pancreatic cancer, detection of K-ras in these materials is an attractive approach to diagnosis. Read More

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October 2001
2 Reads

Neutropenia is not required for clinical remission during azathioprine therapy in inflammatory bowel disease.

Eur J Gastroenterol Hepatol 2001 Sep;13(9):1053-5

Mount Sinai Medical Center, 12 East 86th Street, New York, NY 10029, USA.

Inflammatory bowel disease is an idiopathic chronic inflammatory process of the gastrointestinal tract. The aetiology remains unknown but probably involves a combination of genetic susceptibility, environmental triggers and abnormal immune regulation. Immunomodulators are effective in treating inflammatory bowel disease. Read More

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September 2001
5 Reads

Nutritional treatment with branched-chain amino acids in advanced liver cirrhosis.

J Gastroenterol 2000 ;35 Suppl 12:7-12

Department of Internal Medicine and Gastroenterology, University of Bologna, Policlinico S Orsola, Italy.

During the last 20 years there has been much interest in nutritional treatment for patients with advanced cirrhosis. Most studies have measured the potential benefit of nutritional supplements of dietary proteins, generic protein hydrolysates, or specific branched-chain amino acid (BCAA)-enriched formulas in regard to nutritional parameters and hepatic encephalopathy. The issue is not definitively settled; data are conflicting and meta-analyses have failed to produce unequivocal results. Read More

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June 2000
4 Reads

Interferon treatment of chronic hepatitis C in patients with hemophilia or von Willebrand's disease in Japan.

J Gastroenterol 1995 Jun;30(3):367-71

Third Department of Internal Medicine, Nara Medical University, Japan.

Seven patients with chronic hepatitis C, six hemophiliacs and a patient with von Willebrand's disease, were treated with interferon-alpha (IFN-alpha). Either 9 MU of recombinant IFN-alpha 2a or 3 MU of lymphoblastoid alpha-IFN was administered daily for 2 weeks and then three times a week for 22 weeks. Liver histology, hepatitis C virus (HCV) genotypes, and HCV-RNA levels in sera were investigated in all of the patients before IFN therapy was instituted. Read More

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June 1995
2 Reads
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