291,944 results match your criteria European Journal of Dental Education [Journal]


[Results of Reinsertion of the Distal Achilles Tendon].

Authors:
Heinz Lohrer

Z Orthop Unfall 2018 Dec 6. Epub 2018 Dec 6.

Zentrum für Sportorthopädie, European SportsCare Network (ESN), Wiesbaden-Nordenstadt.

Background: Reattachment of the distal Achilles tendon to the posterior calcaneus following distal Achilles tendon tears/avulsions or after excision of large posterior heel spurs is a challenging task for the orthopaedic surgeon.

Patients/material And Methods: Between 2005 and the end of 2015, 22 patients who underwent repair/reconstruction of a lesion of the distal Achilles tendon were identified from our electronic records. Calcaneal reinsertions were performed following distal Achilles tendon tears/avulsions (n = 15) or following excision of a large symptomatic posterior heel spur (n = 7). Read More

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December 2018
2 Reads

Measurement of absolute γ-ray emission probabilities in the decay of Ac in equilibrium with its progeny.

Appl Radiat Isot 2018 Aug 30;144:34-46. Epub 2018 Aug 30.

European Commission, Joint Research Centre, Directorate for Nuclear Safety and Security, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany. Electronic address:

The emission probabilities of γ rays produced in the Ac decay series were determined by high-resolution γ-ray spectrometry of sources with standardised activity. The sources were prepared quantitatively on glass discs by drop deposition of a solution with Ac in radioactive equilibrium with its daughter nuclides. Their activity was measured by a primary standardisation technique based on alpha-particle counting at a defined low solid angle. Read More

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The legacy of colonial fire management policies on traditional livelihoods and ecological sustainability in savannas: Impacts, consequences, new directions.

J Environ Manage 2018 Dec 3;232:600-606. Epub 2018 Dec 3.

Darwin Centre for Bushfire Research, Charles Darwin University, Darwin, Australia. Electronic address:

Land occupation and management systems have defined fire regimes and landscapes for millennia. The savanna biome is responsible for 86% of all fire events, contributes to 10% of the total carbon emissions annually and is home to 10% of the human population. European colonization has been associated with the implementation of fire suppression policies in many tropical savanna regions, markedly disrupting traditional fire management practices and transforming ecosystems. Read More

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December 2018
2 Reads

Non-GVHD ocular complications after hematopoietic cell transplantation: expert review from the Late Effects and Quality of Life Working Committee of the CIBMTR and Transplant Complications Working Party of the EBMT.

Biol Blood Marrow Transplant 2018 Dec 3. Epub 2018 Dec 3.

Department of Ophthalmology, Hospital Universitario Puerta de Hierro, Madrid, Spain.

Non-graft-versus-host disease (non-GVHD) ocular complications are generally uncommon after hematopoietic cell transplantation (HCT), but can cause prolonged morbidity affecting activities of daily living and quality of life. Here we provide an expert review of non-GVHD ocular complications in a collaboration between transplant physicians and ophthalmologists through the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and the Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation. Complications discussed in this review include cataracts, glaucoma, ocular infections, ocular involvement with malignancy, ischemic microvascular retinopathy, central retinal vein occlusion, retinal hemorrhage, retinal detachment and ocular toxicities associated with medications. Read More

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December 2018
2 Reads

Early impact of pulmonary stereotactic fractionated body radiotherapy (SBRT) on Quality of Life (QoL): Benefit for patients with low initial scores (STRIPE trial).

J Thorac Oncol 2018 Dec 3. Epub 2018 Dec 3.

Department of Radiation Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Germany; German Cancer Consortium (DKTK) Partner Site Freiburg, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany.

Introduction: Quality of life (QoL) of comorbid patients with pulmonary malignancies is a key issue in considering stereotactic fractionated body radiotherapy (SBRT) indication. This study investigates the early impact of SBRT on QoL.

Methods: 100 patients with pulmonary lesions were treated with SBRT from 02/2011 to 11/2014 within the prospective, monocenter, phase II STRIPE trial. Read More

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December 2018
1 Read

Health literacy in men and women with cardiovascular diseases and its association with the use of health care services - Results from the population-based GEDA2014/2015-EHIS survey in Germany.

PLoS One 2018 6;13(12):e0208303. Epub 2018 Dec 6.

Department of Epidemiology and Health Monitoring, Robert Koch Institute Berlin, Berlin, Germany.

Background: Health literacy (HL), defined as the ability to access, understand, appraise and apply health information, offers a promising approach to reduce the development of cardiovascular diseases (CVD) and to improve the management of CVD in populations.

Design: We used data from nationwide cross-sectional German Health Update (GEDA2014/2015-EHIS) survey. 13,577 adults ≥ 40 years completed a comprehensive standardized paper or online questionnaire including the short form of the European Health Literacy Survey Questionnaire (HLS-EU-Q16). Read More

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December 2018

The multiple maternal legacy of the Late Iron Age group of Urville-Nacqueville (France, Normandy) documents a long-standing genetic contact zone in northwestern France.

PLoS One 2018 6;13(12):e0207459. Epub 2018 Dec 6.

De la Préhistoire à l'Actuel, Culture, Environnement, Anthropologie-UMR 5199, CNRS, Université de Bordeaux, Allée Geoffroy Saint-Hilaire, CS, Pessac Cedex, France.

The compilation of archaeological and genetic data for ancient European human groups has provided persuasive evidence for a complex series of migrations, population replacements and admixture until the Bronze Age. If the Bronze-to-Iron Age transition has been well documented archaeologically, ancient DNA (aDNA) remains rare for the latter period and does not precisely reflect the genetic diversity of European Celtic groups. In order to document the evolution of European communities, we analysed 45 individuals from the Late Iron Age (La Tène) Urville-Nacqueville necropolis in northwestern France, a region recognized as a major cultural contact zone between groups from both sides of the Channel. Read More

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December 2018

Validity and measurement invariance across sex, age, and education level of the French short versions of the European Health Literacy Survey Questionnaire.

PLoS One 2018 6;13(12):e0208091. Epub 2018 Dec 6.

Université Paris-Saclay, Univ. Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France.

Background: Short versions of the European Health Literacy Survey (HLS-EU) questionnaire are increasingly used to measure and compare health literacy (HL) in populations worldwide. As no validated versions of these questionnaires have thus far appeared in French, this study aimed to study the psychometric properties of the French translation of the 16- and 6-item short versions (HLS-EU-Q16 and HLS-EU-Q6), including their measurement invariance across sex, age, and education level.

Methods: A consensual French version of the HLS-EU-Q16 and HLS-EU-Q6 was developed by following the current recommendations for transcultural questionnaire adaptation. Read More

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December 2018

Temporal changes in the viromes of Swedish Varroa-resistant and Varroa-susceptible honeybee populations.

PLoS One 2018 6;13(12):e0206938. Epub 2018 Dec 6.

Department of Ecology, Swedish University of Agricultural Sciences, Uppsala, Sweden.

The parasitic mite, Varroa destructor, in combination with the viruses it vectors, is the main cause for global colony losses of the European honeybee, Apis mellifera. However, an isolated honeybee population established in 1999 on the Island of Gotland, Sweden has naturally acquired resistance to the mite, and has survived without mite control treatment for more than 18 years. A recent study has shown that this mite resistant (MR) population also appears to be resistant to Black queen cell virus (BQCV) and Sacbrood virus (SBV) and tolerant to Deformed wing virus (DWV), relative to nearby mite susceptible (MS) honeybee populations. Read More

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December 2018
1 Read

Histological Subtypes and Clinical Behavior Evaluation of Salivary Gland Tumors.

Acta Med Port 2018 Nov 30;31(11):641-647. Epub 2018 Nov 30.

Department of Pathology. Centro Hospitalar São João. Porto. Unit of Pathology and Oncology. Department of Pathology. Faculdade de Medicina. Universidade do Porto. Porto. Portugal.

Introduction: Salivary gland tumors include a wide spectrum of histological subtypes and clinical behavior, which we aim to evaluate.

Material And Methods: We performed a retrospective study of all salivary gland tumors diagnosed and treated at the Centro Hospitalar São João, Porto, between 2005 and 2015. Histological re- evaluation was performed in all cases and patient files were reviewed and both clinical and follow-up data were collected. Read More

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November 2018
3 Reads

Is There a Surplus of Non-Specialist Physicians in Portugal or Just Poor Human Resources Planning?

Acta Med Port 2018 Nov 30;31(11):609-611. Epub 2018 Nov 30.

Acta Médica Portuguesa. Lisboa. Department of Otorhinolaryngology. Coimbra University Hospitals. Coimbra. Faculty of Medicine. University of Coimbra. Coimbra. Portugal.

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November 2018

Global Development of Anticancer Therapies for Rare Cancers, Pediatric Cancers, and Molecular Subtypes of Common Cancers.

J Glob Oncol 2018 Dec(4):1-11

H. Kim Lyerly, Duke University, Durham, NC; Jun Ren, Capital University Medical Center; Zhimin Yang, China Food and Drug Administration, Beijing, People's Republic of China; Gi Hyun Kim, Korea Ministry of Food and Drug Safety, Seoul, South Korea; Sumimasa Nagai, University of Tokyo; Sumimasa Nagai, Tomohiro Yamaguchi, and Ken Hatogai, Pharmaceuticals and Medical Devices Agency; Hiroshi Katayama, National Cancer Center Hospital, Tokyo, Japan; Silvy Da Rocha Dias, European Medicines Agency, London, United Kingdom; Daniel McManus and Kathy Soltys, Health Canada, Ottawa, Ontario, Canada; Olufumilayo Olopade, University of Chicago, Chicago, IL; Nancy Goodman, Kids V Cancer, Washington, DC; Greg Reaman, US Food and Drug Administration; Thomas Gross, US National Cancer Institute, Bethesda, MD, and Renzo Canetta, Independent Consultant.

Advances in genetic sequencing and other diagnostic technologies have enabled the use of precision medicine in clinical cancer care, as well as the development of novel therapies that are targeted to specific molecular drivers of cancer. Developing these new agents and making them accessible to patients requires global clinical studies and regulatory review and approval by different national regulatory agencies. Whereas these global trials present challenges for drug developers who conduct them and regulatory agencies who oversee them, they also raise practical issues about patients with low-frequency cancers who need these therapies. Read More

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December 2018
1 Read

Towards a regulation of HTA in Europe: the proposal from the European Commission.

Authors:
Antonio Migliore

Expert Rev Med Devices 2018 Dec 6. Epub 2018 Dec 6.

a Agenas, Agenzia nazionale per i servizi sanitari regionali - Sez. Innovazione , Sperimentazione e sviluppo via Puglie 23, Rome 00187 , Italy.

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December 2018

Validation of the 2017 European LeukemiaNet classification for acute myeloid leukemia with NPM1 and FLT3-internal tandem duplication genotypes.

Cancer 2018 Dec 6. Epub 2018 Dec 6.

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: The revised 2017 European LeukemiaNet (ELN) classification (ELN-2017) of acute myeloid leukemia (AML) divides patients into 3 prognostic risk categories, with additional factors such as the fms-like tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD) allele ratio (AR) considered for risk stratification. To the best of the authors' knowledge, the prognostic usefulness of ELN-2017 in comparison with ELN-2010 in younger patients with AML has not been validated to date.

Methods: The authors performed a retrospective study on patients aged <60 years who received idarubicin plus cytarabine (IA)-based induction chemotherapy for newly diagnosed AML. Read More

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December 2018

Orchestration of Tryptophan-Kynurenine pathway, acute decompensation and acute-on-chronic liver failure in cirrhosis.

Hepatology 2018 Dec 6. Epub 2018 Dec 6.

EF Clif, EASL-CLIF Consortium and Grifols Chair, Barcelona, Spain.

Systemic inflammation (SI) is involved in the pathogenesis of acute decompensation (AD) and acute-on-chronic liver failure (ACLF) in cirrhosis. In other diseases, SI activates tryptophan (Trp) degradation via the kynurenine pathway (KP), giving rise to metabolites that contribute to multiorgan/system damage and immunosuppression. In the current study, we aimed to characterize the KP in patients with cirrhosis, in whom this pathway is poorly known. Read More

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December 2018
4 Reads

Efficacy of a polyvalent injectable vaccine against Flavobacterium psychrophilum administered to rainbow trout (Oncorhynchus mykiss L.).

J Fish Dis 2018 Dec 6. Epub 2018 Dec 6.

Institute of Aquaculture, University of Stirling, Stirling, UK.

Flavobacterium psychrophilum is one of the most important pathogens affecting cultured rainbow trout (Oncorhynchus mykiss). Recent information from UK salmonid farms showed country-wide distribution of genetically and serologically divergent clones, which has hampered the development of a vaccine for rainbow trout fry syndrome. The current study assessed the efficacy of an injectable polyvalent vaccine containing formalin-inactivated F. Read More

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December 2018
2 Reads

Out-of-pocket Costs for Individuals with Atopic Eczema: A Cross-sectional Study in Nine European Countries.

Acta Derm Venereol 2018 Dec 6. Epub 2018 Dec 6.

Department of Dermatology and Allergy, Technical University Munich, Biedersteinerstrasse 29, DE-80802 Munich, Germany.

Atopic eczema (AE) is one of the most common non-communicable inflammatory skin diseases, and has a huge socioeconomic impact. Studies on the everyday economic impact of AE on patients, however, are limited. To estimate the annual extra out-of-pocket spending due to AE among patients in Europe, a cross-sectional study using computer-assisted phone interviewing of patients with AE was performed in 9 European countries. Read More

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December 2018
3 Reads

Insomnia in breast cancer: a prospective observational study.

Sleep 2018 Dec 5. Epub 2018 Dec 5.

CRUK Clinical Trials Unit, Institute of Cancer Sciences, University of Glasgow.

Study Objectives: Insomnia in cancer patients is prevalent, persistent and confers risk for physical and psychological disorder. We must better understand how insomnia develops in cancer patients and explore the main contributors to its chronicity so that insomnia management protocols can be integrated more effectively within cancer care. This study monitors the etiology of insomnia in breast cancer patients and identifies risk factors for its persistence. Read More

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December 2018
2 Reads

Practice patterns of surgery for advanced ovarian cancer: analysis from international surveys.

Jpn J Clin Oncol 2018 Dec 6. Epub 2018 Dec 6.

Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea.

Background: We investigated the practice patterns of surgery for advanced ovarian cancer (AOC) through relevant international surveys.

Methods: After searching for 878 studies on surgery for AOC till 2017, we extracted 18 questions with similar query and answer formats from eight studies. Among them, 5 and 13 were classified as comprehensive and procedure information. Read More

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December 2018
2 Reads

Education and mortality in three Eastern European populations: findings from the PrivMort retrospective cohort study.

Eur J Public Health 2018 Dec 5. Epub 2018 Dec 5.

Department of Economics, University of Massachusetts, Amherst, USA.

Background: The aim of the study is 2-fold. Firstly, it attempts to investigate the potential impact of major political and economic changes on inequalities in all-cause mortality among men and women with different levels of education in three Eastern European countries. Secondly, to identify changes in contribution of smoking and drinking to educational differences in all-cause mortality. Read More

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December 2018
1 Read

Alfred: Interactive multi-sample BAM alignment statistics, feature counting and feature annotation for long- and short-read sequencing.

Bioinformatics 2018 Dec 6. Epub 2018 Dec 6.

GeneCore, European Molecular Biology Laboratory (EMBL), Heidelberg, 69117, Germany.

Summary/motivation: Harmonizing quality control of large-scale second and third-generation sequencing datasets is key for enabling downstream computational and biological analyses. We present Alfred, an efficient and versatile command-line application that computes multi-sample quality control metrics in a read-group aware manner, across a wide variety of sequencing assays and technologies. In addition to standard quality control metrics such as GC bias, base composition, insert size and sequencing coverage distributions it supports haplotype-aware and allele-specific feature counting and feature annotation. Read More

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December 2018

Pretest probability for patients with suspected obstructive coronary artery disease: re-evaluating Diamond-Forrester for the contemporary era and clinical implications: insights from the PROMISE trial.

Eur Heart J Cardiovasc Imaging 2018 Dec 5. Epub 2018 Dec 5.

Cardiac MR PET CT Program, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 165 Cambridge Street, Suite 400, Boston, USA.

Aims: To update pretest probabilities (PTP) for obstructive coronary artery disease (CAD ≥ 50%) across age, sex, and clinical symptom strata, using coronary computed tomography angiography (CTA) in a large contemporary population of patients with stable chest pain referred to non-invasive testing.

Methods And Results: We included patients enrolled in the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial and randomized to CTA. Exclusively level III-certified readers, blinded to demographic and clinical data, assessed the prevalence of CAD ≥ 50% in a central core lab. Read More

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December 2018

The European Open Science Cloud and commercialization.

Authors:
Helen Yu

Nat Biotechnol 2018 Dec;36(12):1133-1134

Faculty of Law, University of Copenhagen, Copenhagen, Denmark.

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December 2018

Auxiliary subunits keep AMPA receptors compact during activation and desensitization.

Elife 2018 Dec 6;7. Epub 2018 Dec 6.

Institute of Biology, Cellular Biophysics, Humboldt Universität zu Berlin, Berlin, Germany.

Signal transduction at vertebrate excitatory synapses involves the rapid activation of AMPA (a-amino-3-hydroxy-5-methyl-4-isoxazole propionate) receptors, glutamate-gated ion channels whose four subunits assemble as a dimer-of-dimers. Technical advances in cryo-electron microscopy brought a slew of full-length structures of AMPA receptors, on their own and in combination with auxiliary subunits. These structures indicate that dimers might undergo substantial lateral motions during gating, opening up the extracellular layer along the central 2-fold symmetry axis. Read More

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December 2018
1 Read

Social behaviour and making attachments: a report from the fifth 'Young Microbiologists Symposium on Microbe Signalling, Organisation and Pathogenesis'.

Microbiology 2018 Dec 6. Epub 2018 Dec 6.

1​Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK.

The fifth Young Microbiologists Symposium was held in Queen's University Belfast, Northern Ireland, in late August 2018. The symposium, focused on 'Microbe signalling, organization and pathogenesis', attracted 121 microbiologists from 15 countries. The meeting allowed junior scientists to present their work to a broad audience, and was supported by the European Molecular Biology Organization, the Federation of European Microbiological Societies, the Society of Applied Microbiology, the Biochemical Society and the Microbiology Society. Read More

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December 2018
1 Read

Spatial analysis of lumpy skin disease (LSD) in Eurasia - Predicting areas at risk for further spread within the region.

Transbound Emerg Dis 2018 Dec 6. Epub 2018 Dec 6.

Food and Agriculture Organization (FAO), Regional Office for Europe and Central Asia, Budapest, Hungary.

Data from affected lumpy skin disease (LSD) locations between July 2012 and September 2018 in the Balkans, Caucasus and Middle East were retrieved from FAO's Global Animal Disease Information System (EMPRES-i) from the European Commission's Animal Disease Notification System (ADNS) and completed with data from the official veterinary services of some countries. During this period, a total of 7,593 locations from twenty-two countries were affected. Within this period, over 46,000 cattle were clinically affected by LSD, 3,700 animals died and 17,500 were slaughtered due to culling policies to stop the spread of the disease. Read More

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December 2018
2 Reads

[What's new in the 2018 ESC/EACTS guidelines on myocardial revascularization?]

G Ital Cardiol (Rome) 2018 Nov;19(11):5-9

Klinik für Kardiologie und Angiologie II, Universitäts-Herzzentrum Freiburg, Bad Krozingen, Germania.

A revised version of the European Society of Cardiology (ESC) and European Association for Cardio-Thoracic Surgery (EACTS) guidelines on myocardial revascularization has recently been published. These guidelines represent the third time that the ESC and EACTS have brought together cardiologists and cardiac surgeons in a joint Task Force to review the available evidence, with the mission of drafting balanced, patient-oriented, clinical practice guidelines on myocardial revascularization. During the last 4 years, a large body of evidence has become available and brought substantial changes to the guidelines. Read More

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November 2018

Evaluation of the safety of users of active implantable medical devices (AIMD) in the working environment in terms of exposure to electromagnetic fields - practical approach to the requirements of European Directive 2013/35/EU.

Int J Occup Med Environ Health 2018 Nov 5. Epub 2018 Nov 5.

Central Institute for Labour Protection - National Research Institute, Warszawa, Poland (Laboratory of Electromagnetic Hazards).

Objectives: Electromagnetic fields (EMF) may cause malfunctions in electronic devices, in particular in active implantable medical devices (AIMD), along with discomfort or health hazards to users. The use of AIMD by workers is increasing (especially cardiac pacemakers, implantable cardioverter defibrillators and wearable insulin infusion pumps). Electromagnetic fields may be much stronger in the working environment than applied in basic immunity tests of AIMD (based on EN 60601- 1-2:2015 and EN 50527-1:2016). Read More

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November 2018
1 Read

The real-life data of hospitalized patients with heart failure: On behalf of the Journey HF-TR study investigators.

Anatol J Cardiol 2018 Dec 6. Epub 2018 Dec 6.

Department of Cardiology, Faculty of Medicine, İstanbul University, Institute of Cardiology; İstanbul-Turkey.

Objective: Acute heart failure (AHF) is a life-threatening clinical syndrome characterized by rapid onset of heart failure (HF) symptoms and signs and requires urgent therapy. The aim of the present study was to evaluate the overall clinical characteristics, management, and in-hospital outcomes of hospitalized patients with AHF in a large sample of Turkish population.

Methods: The Journey HF-TR study is a cross-sectional, multicenter, non-invasive and observational trial. Read More

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December 2018

An amended description of two Gyrodactylus species (Platyhelminthes: Monogenea) parasitizing Antarctic Notothenioid fish.

J Helminthol 2018 Dec 6:1-9. Epub 2018 Dec 6.

Department of Botany and Zoology,Faculty of Science,Masaryk University,Brno,Czech Republic.

Species identification based on the morphometry of opisthaptoral hard parts, in combination with internal transcribed spacer ribosomal DNA (ITS rDNA) region sequences, confirmed the presence of four viviparous Gyrodactylus von Nordman, 1832 (Plathyhelminthes, Monogenea) species on Nototheniid fish from the Prince Gustav Channel (Weddell Sea, Antarctica). Gyrodactylus antarcticus Gusev, 1967 was found mostly on Trematomus newnesi Boulenger (93 specimens) but also on T. bernacchii Boulenger (one specimen), the latter representing a new host record for this species. Read More

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December 2018

Prevalence of pharmacogenomic variants affecting the efficacy of clopidogrel therapy in the Hispanic Community Health Study/Study of Latinos cohort.

Pharmacogenomics 2018 Dec 6. Epub 2018 Dec 6.

Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Purpose: Although clopidogrel is the most widely used oral P2Y12 receptor antagonist, up to 10% of acute coronary syndrome patients treated with clopidogrel will experience a recurrent myocardial infarction and 2-3% will experience stent thrombosis within 1 year. The purpose of this research is to describe the prevalence of pharmacogene variants associated with clopidogrel responsiveness (CYP2C19, B4GALT2, ABCB1, PON1, CES1 and P2RY12) in Hispanic/Latino patients of diverse backgrounds.

Methods: Minor allele frequencies of nine variants from participants of Hispanic Community Health Study/Study of Latinos were compared between subpopulations as well as to continental ancestry references using z-test for independent proportions. Read More

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December 2018
2 Reads

Scombrotoxic Fish Poisoning Secondary to Tuna Ingestion

Ir Med J 2018 06 7;111(6):773. Epub 2018 Jun 7.

South Lee Environmental Health Services, HSE- South, Cork, Ireland.

Scombrotoxic poisoning results from the improper handling and refrigeration of fish containing naturally occurring histidine. Scombroid fish species such as tuna, mackerel and swordfish contain histidine, which is converted to histamine when inadequately chilled. European legislation states that scombroid fish species should be tested for the presence of histamine and mean values should be <100mg/kg1. Read More

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Assessing the population relevance of endocrine disrupting effects for non-target vertebrates exposed to plant protection products.

Integr Environ Assess Manag 2018 Dec 6. Epub 2018 Dec 6.

Corteva AgriscienceTM, Agriculture Division of DowDuPontTM, 3B Park Square, Milton Park, Abingdon, Oxfordshire, OX14 4RN, UK.

The European Commission intends to protect vertebrate wildlife populations by regulating Plant Protection Product (PPP) active substances that have endocrine disrupting properties with a hazard-based approach. In this paper we consider how the Commission's hazard-based Regulation and accompanying Guidance can be operationalised to ensure that a technically robust process is used to distinguish between substances with adverse population level effects and those for which it can be demonstrated that adverse effects observed (typically in the laboratory) do not translate into adverse effects at the population level. Our approach is to use population models within the adverse outcome pathway framework to link the non-linear relationship between adverse effects at the individual and population levels in the following way: (1) Use Specific Protection Goals for focal wildlife populations within an ecosystem services framework; (2) Model the effects of changes in population-related inputs on focal species populations using individual-based population models to determine thresholds between negligible and non-negligible (i. Read More

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December 2018

Abstracts for ESCCA 2018 Conference: At the Shore of Future Cytometry September 13-15, 2018, Valencia, Spain.

Authors:

Cytometry B Clin Cytom 2018 Dec 5. Epub 2018 Dec 5.

We are pleased to present abstracts from ESCCA 2018: At the Shore of Future Cytometry. This year, the European Society for Clinical Cell Analysis (ESCCA) organised its annual Conference over 3 days in Valencia, Spain. Four workshops for a limited number of participants - dedicated to Cytometry Analysis Tools, Cytometry of Microparticles, Cytometry in Veterinary and Animal Sciences and CLL MRD - as well as ESCCA certification exams took place before the Conference. Read More

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December 2018

Response shift effects of quality of life assessments in breast cancer survivors.

Eur J Cancer Care (Engl) 2018 Dec 6:e12979. Epub 2018 Dec 6.

Department of Medical Psychology and Medical Sociology, University of Leipzig, Leipzig, Germany.

Measurements of quality of life (QoL) can be distorted by respondents adapting to new situations between measurement points and consequently having a changed frame of reference. To investigate this bias in breast cancer survivors, we compare their QoL with that of the general population and use two complementary methods for detecting this bias. Breast cancer survivors (n = 308, response rate: 91%) were tested with the QoL questionnaire European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30. Read More

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December 2018
1 Read

Non-genetic and genetic predictors of a superficial first basal cell carcinoma.

J Eur Acad Dermatol Venereol 2018 Dec 6. Epub 2018 Dec 6.

Department of Dermatology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.

Background: several observational studies have suggested differences in the risk factor profile between patients with superficial basal cell carcinomas (BCCs) and non-superficial BCCs.

Objective: to test the reproducibility of previous study findings and to find new genetic and non-genetic predictors for patients with a superficial first BCC.

Methods: 14. Read More

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December 2018
1 Read

Regrets after tattooing and tattoo removal in the general population of France.

J Eur Acad Dermatol Venereol 2018 Dec 5. Epub 2018 Dec 5.

FIMARAD, Hopital Necker Enfants Malades, Paris, France.

The market of tattoo removal is constantly rising [1]. Recent American polls showed a growing proportion of tattooed individuals that regretted getting tattooed: nearly one fourth (23%) in 2016 against 14% in 2012 [2]. In France, a recent poll in 2016 in France showed that 7% of the tattooed individuals had a tattoo removed [3]. Read More

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December 2018
3 Reads

Methotrexate in atopic eczema - Reply to a letter.

J Eur Acad Dermatol Venereol 2018 Dec 5. Epub 2018 Dec 5.

Department Dermatology and Allergy Biederstein, Technische Universität München, Munich, Germany and, Christine Kühne-Center for Allergy Research and Education (CK-CARE)Davos.

Goujon et al. submit a letter-type manuscript to JEADV (1), as a comment to the recently published European consensus-based S2k guidelines or treatment of atopic eczema (2,3). The assigned writing subgroups for each topic were encouraged to include the 'best available evidence' for all chapters of the guideline (2). Read More

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December 2018
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Letter to the Editor: Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part II. JEADV 2018, 32, 850-878. doi.org/10.1111/jdv.14888.

J Eur Acad Dermatol Venereol 2018 Dec 6. Epub 2018 Dec 6.

Head Research & Head Outpatient Clinic, Department of Dermatology, University Hospital Zürich, Switzerland.

We read with interest and with full consent the new consensus-based European guidelines for the treatment of atopic eczema, Part II . However, we would like to comment on the section on microbial textiles where the recommendation to use silk garments with permanent antimicrobial in the management of children with moderate to severe eczema is raised. On the basis of an UK multicenter clinical trial which seemed to show that silk garments with permanent antimicrobial were ineffective in the treatment of children with atopic eczema, the guidelines deny now any clinical benefit of AEGIS-coated silk textiles in children with atopic eczema and this contrary to the previous two guidelines . Read More

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December 2018
1 Read

Methotrexate in atopic eczema. Comments to: Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part II.

J Eur Acad Dermatol Venereol 2018 Dec 5. Epub 2018 Dec 5.

Allergy and Clinical Immunology Department, Lyon Sud University Hospital, Pierre Bénite, University of Lyon, France.

The recent European guidelines for the treatment of atopic eczema (AE) are a thorough overview of therapeutic opportunities for AE. Among the systemic treatments, we propose to bring further insights on methotrexate (MTX) use in adult AE patients. This article is protected by copyright. Read More

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December 2018

Reply to a correspondence addressing the European guideline for treatment of atopic eczema, functional textiles and the CLOTHES trial.

J Eur Acad Dermatol Venereol 2018 Dec 5. Epub 2018 Dec 5.

Department Dermatology and Allergy Biederstein, Technische Universität München Munich, Germany and Christine Kühne-Center for Allergy Research and Education (CK-CARE)Davos.

We have read with interest the respectfully written correspondence by Wüthrich et al. regarding antimicrobial silk textiles for atopic dermatitis (AD) (1). Though it was submitted as a comment to the European consensus-based S2k guidelines on treatment of atopic eczema (2,3), it is discussing in 70% of its length the CLOTHES trial - published in two non-JEADV-publications which we have neither designed nor authored (4,5). Read More

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December 2018
1 Read

Hepatic Resection Compared to Chemoembolization in Intermediate to Advanced-Stage HCC: a comment for moving forward.

Hepatology 2018 Dec 5. Epub 2018 Dec 5.

Hepatobiliary Surgery Department, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China.

Treatment of hepatocellular carcinoma (HCC) depends on disease staging, which is usually performed according to the Barcelona Clinic Liver Cancer (BCLC) system. Although the BCLC system is recommended in the guidelines from the European Association for the Study of the Liver, the American Association for the Study of Liver Diseases, and the European Society for Medical Oncology , its treatment recommendations for intermediate and advanced HCC are inconsistent with the literature. This article is protected by copyright. Read More

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December 2018
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European Surveillance System on Contact Allergies (ESSCA): contact allergies in relation to body sites in patients with allergic contact dermatitis.

Contact Dermatitis 2018 Dec 5. Epub 2018 Dec 5.

University of Groningen, University Medical Center Groningen, Department of Dermatology, The Netherlands.

Background: Analyses of the European Surveillance System on Contact Allergies (ESSCA) database have focused primarily on prevalence of contact allergies to the European baseline series; overall and in subgroups of patients. However, affected body sites have hitherto not been addressed.

Objective: To determine prevalence of contact allergies for distinct body sites in patients with allergic contact dermatitis (ACD). Read More

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December 2018
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Abortion by telemedicine in the European Union.

Int J Gynaecol Obstet 2018 Dec 5. Epub 2018 Dec 5.

Kent Law School, University of Kent, Canterbury, UK.

This paper analyses an important set of legal issues raised by the telemedical provision of abortion pills. Focusing on the case of European Union (EU) law, it suggests that a properly accredited doctor seeking to treat a patient with abortion pills is entitled, in principle, to rely on EU rules of free movement to protect their access to patients in other member states, and women facing unwanted pregnancies likewise have legal rights to access the services thus offered. EU countries seeking to claim an exception to those rules on the basis of public health or the protection of a fundamental public policy interest (here, the protection of fetal life) will face significant barriers. Read More

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December 2018
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Automated segmentation of trabecular and cortical bone from proton density weighted MRI of the knee.

Med Biol Eng Comput 2018 Dec 5. Epub 2018 Dec 5.

Department of Biomechanical Engineering, University of Twente, Drienerlolaan 5, 7500 AE, Enschede, the Netherlands.

Patient-specific implant design and pre- and intra-operative planning is becoming increasingly important in the orthopaedic field. For clinical feasibility of these techniques, fast and accurate segmentation of bone structures from MRI is essential. However, manual segmentation is time intensive and subject to inter- and intra-observer variation. Read More

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December 2018

PREDECT Protocols for Complex 2D/3D Cultures.

Methods Mol Biol 2019 ;1888:1-20

Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riß, Germany.

PREDECT, a European IMI consortium, has assumed the task to generate robust 2D and 3D culture platforms. Protocols established for 2D and 3D monoculture and stromal coculture models of increasing complexity (spheroid, stirred-tank bioreactor, Matrigel- and collagen-embedded cultures) have been established between six laboratories within academia, biotech, and pharma. These models were tested using three tumor cell lines (MCF7, LNCaP, and NCI-H1437), covering three pathologies (breast, prostate, and lung), but should be readily transferable to other model systems. Read More

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January 2019

Technical challenges of quantitative chest MRI data analysis in a large cohort pediatric study.

Eur Radiol 2018 Dec 5. Epub 2018 Dec 5.

Department of Pediatrics, Division of Respiratory Medicine and Allergology, Erasmus Medical Center, Wytemaweg 80, 3015 CN, Rotterdam, the Netherlands.

Objectives: This study was conducted in order to evaluate the effect of geometric distortion (GD) on MRI lung volume quantification and evaluate available manual, semi-automated, and fully automated methods for lung segmentation.

Methods: A phantom was scanned with MRI and CT. GD was quantified as the difference in phantom's volume between MRI and CT, with CT as gold standard. Read More

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December 2018

eQTL of KCNK2 regionally influences the brain sulcal widening: evidence from 15,597 UK Biobank participants with neuroimaging data.

Brain Struct Funct 2018 Dec 5. Epub 2018 Dec 5.

UNATI, Institut Joliot, CEA, Université Paris-Saclay, Neurospin, CEA Saclay, Neurospin Bâtiment 145, 91191, Gif-sur-Yvette Cedex, France.

The grey and white matter volumes are known to reduce with age. This cortical shrinkage is visible on magnetic resonance images and is conveniently identified by the increased volume of cerebrospinal fluid in the sulci between two gyri. Here, we replicated this finding using the UK Biobank dataset and studied the genetic influence on these cortical features of aging. Read More

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December 2018
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