8,870 results match your criteria European Journal of Clinical Pharmacology[Journal]
Eur J Clin Pharmacol 2019 Feb 18. Epub 2019 Feb 18.
Division of Hemostaseology, University Hospital Leipzig, Liebigstr, 20, 04103, Leipzig, Germany.
Purpose: The inhibitory effect of metamizole on platelet aggregation is known for several years, but most studies were conducted in healthy volunteers with contradictory results. Recent studies have shown an inhibitory effect of metamizole on acetylsalicylic acid (ASA)-induced platelet aggregation. We aimed to investigate the effect of metamizole on platelet aggregation after an elective surgery and the effect of metamizole on ASA-induced platelet aggregation in hospitalized patients. Read More
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http://dx.doi.org/10.1007/s00228-019-02646-9 | DOI Listing |
Eur J Clin Pharmacol 2019 Feb 18. Epub 2019 Feb 18.
Department of Clinical Pharmacy, Rijnstate Hospital, Wagnerlaan 55, 6815 AD, Arnhem, The Netherlands.
Introduction: Selective decontamination of the digestive tract (SDD) is a strategy in mechanically ventilated patients to reduce mortality. Treatment consists of enterally administered non-absorbable antibiotics, i.e. Read More
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http://dx.doi.org/10.1007/s00228-019-02644-x | DOI Listing |
Eur J Clin Pharmacol 2019 Feb 15. Epub 2019 Feb 15.
Department of Pharmacy, Tokyo Women's Medical University Medical Center East, 2-1-10, Nishiogu, Arakawa-ku, Tokyo, 116-0011, Japan.
Purpose: Vancomycin (VCM) is used for the treatment of methicillin-resistant Staphylococcus aureus. Although the risk factors for VCM nephrotoxicity have been evaluated, the time course of renal function during VCM treatment is unknown. We assessed risk factors for VCM nephrotoxicity and how renal function varied over time. Read More
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http://dx.doi.org/10.1007/s00228-019-02648-7 | DOI Listing |
Eur J Clin Pharmacol 2019 Feb 14. Epub 2019 Feb 14.
Department of Nephrology and Hypertension, Rabin Medical Center, Beilinson campus, 39, Jabutinsky st., Petah Tikva, Israel.
Purpose: High tacrolimus trough drug level variability was found to be associated with reduced graft survival. The primary goal of this study was to find whether reduction of exposure to high tacrolimus trough level variability in patients in which previously had high variability was associated with better graft survival.
Methods: All tacrolimus drug level values in patients that underwent kidney transplantation at our center between 2006 and 2015 were collected. Read More
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http://dx.doi.org/10.1007/s00228-019-02643-y | DOI Listing |
Eur J Clin Pharmacol 2019 Feb 13. Epub 2019 Feb 13.
Institute of Pharmacy, Department of Clinical Pharmacy and Drug Safety Center, Leipzig University and University Hospital of Leipzig, Bruederstraße 32, 04103, Leipzig, Germany.
Purpose: The individual fall risk of a patient is often multifactorial. Polymedication contributes to an additional risk of fall-risk-increasing adverse reactions (FRIARs). Previous studies have not sufficiently investigated the complexity facing prescribers when balancing the therapeutic benefits of individual drugs against their potential fall risk. Read More
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http://dx.doi.org/10.1007/s00228-019-02628-x | DOI Listing |
Eur J Clin Pharmacol 2019 Feb 13. Epub 2019 Feb 13.
Faculty of Pharmacy, Université de Montréal, Case Postale 6128, Succursale Centre-Ville, Montréal, QC, H3C 3J7, Canada.
Purpose: Some evidence suggests that spironolactone may have a deleterious effect on glucose homeostasis. The objective of this study was to assess whether spironolactone use is associated with a higher risk of developing diabetes in a large cohort of patients with heart failure (HF).
Methods: Two Quebec government administrative databases were used to identify a cohort of hospitalized patients discharged between January 1995 and December 2009 with a primary discharge diagnosis of HF and without secondary discharge diagnosis of diabetes. Read More
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http://dx.doi.org/10.1007/s00228-018-02615-8 | DOI Listing |
Eur J Clin Pharmacol 2019 Feb 12. Epub 2019 Feb 12.
Department of Internal Medicine I, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Kollarova 2, 036 59, Martin, Slovak Republic.
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http://dx.doi.org/10.1007/s00228-019-02647-8 | DOI Listing |
Eur J Clin Pharmacol 2019 Feb 7. Epub 2019 Feb 7.
Department of Neurology, Xiangya Hospital, Central South University, 87 Xiangya road, Changsha, Hunan, China.
Purpose: The IL-2 gene polymorphisms have been reported to be associated with the development of autoimmune disease. However, there are no published studies examining the influence of the IL-2 gene polymorphisms on the response of myasthenia gravis (MG) patients to tacrolimus (Tac). The goal of this study was to investigate the relationship between the polymorphisms of IL-2 and Tac response in MG patients. Read More
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http://dx.doi.org/10.1007/s00228-019-02642-z | DOI Listing |
Eur J Clin Pharmacol 2019 Feb 7. Epub 2019 Feb 7.
Laboratory for Mother and Child Health, Department of Public Health - Istituto di Ricerche Farmacologiche Mario Negri IRCSS, Via Giuseppe La Masa 19, 20156, Milan, Italy.
Purpose: Drug use in the pediatric population still often features off-label prescriptions, particularly for psychotropic drugs. We reviewed the registration status, scientific evidence, and recommendations from the guidelines for antipsychotics used for psychiatric disorders in children.
Methods: Antipsychotic drugs marketed in Italy, the United Kingdom (UK) and United States (US) were identified with the ATC Classification System. Read More
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http://dx.doi.org/10.1007/s00228-019-02641-0 | DOI Listing |
Eur J Clin Pharmacol 2019 Feb 7. Epub 2019 Feb 7.
Department of Clinical Pharmacology and Pharmacy, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, Amsterdam, The Netherlands.
Purpose: To obtain insight into the feasibility of, and the patients' perspective on, dried blood spot (DBS) self-sampling by patients with chronic myeloid leukemia (CML) using nilotinib.
Methods: Sixty-eight patients with CML using nilotinib participated in this multicenter observational study. Patients were asked to perform blood sampling by means of the DBS method at home just before drug intake (trough level) and to complete a questionnaire including demographics and five questions on their experience with DBS self-sampling. Read More
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http://dx.doi.org/10.1007/s00228-019-02640-1 | DOI Listing |
Eur J Clin Pharmacol 2019 Feb 6. Epub 2019 Feb 6.
Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000, Ljubljana, Slovenia.
Purpose: Rivaroxaban is a substrate for ABCB1 transporter and is commonly used in patients undergoing hip or knee replacement surgery for thromboprophylaxis. The objective of this study was to develop a population pharmacokinetic-pharmacodynamic (PK-PD) model to investigate the influence of ABCB1 gene expression and polymorphism on rivaroxaban exposure and anticoagulation effects.
Methods: Five blood samples per patient were collected during 5 days after the surgery for the determination of rivaroxaban concentration in plasma and for determination of prothrombin time and partial thromboplastin time. Read More
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http://dx.doi.org/10.1007/s00228-019-02639-8 | DOI Listing |
Eur J Clin Pharmacol 2019 Feb 6. Epub 2019 Feb 6.
Service on Pharmacokinetics and Generics, Division of Pharmacology and Clinical Evaluation, Department of Human Use Medicines, Spanish Agency for Medicines and Health Care Products (AEMPS), C/ Campezo 1, Edificio 8, Planta 2 A, 28022, Madrid, Spain.
Purpose: The existence of a sex-by-formulation interaction in bioequivalence studies implies that the bioequivalence results (i.e., the test/reference ratio of the pharmacokinetic parameters) obtained in one sex are not similar to those obtained in the other sex. Read More
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http://link.springer.com/10.1007/s00228-019-02632-1 | Publisher Site |
http://dx.doi.org/10.1007/s00228-019-02632-1 | DOI Listing |
Eur J Clin Pharmacol 2019 Feb 5. Epub 2019 Feb 5.
Faculty of Medicine, University of Ljubljana, Vrazov trg 2, SI-1104, Ljubljana, Slovenia.
Purpose: This review focuses on the most common drugs administered to surgical patients during the perioperative period that affect the risk of venous thromboembolism (VTE).
Results: Among analgesics, the risk of VTE is increased in patients treated with diclofenac, ibuprofen, and rofecoxib, but not naproxen, while metamizole can confer a protective effect. The relationship between sedatives and VTE has not been sufficiently studied. Read More
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http://link.springer.com/10.1007/s00228-019-02636-x | Publisher Site |
http://dx.doi.org/10.1007/s00228-019-02636-x | DOI Listing |
Eur J Clin Pharmacol 2019 Jan 31. Epub 2019 Jan 31.
Institut für Pharmazie und Lebensmittelchemie, Universität Würzburg, Am Hubland, 97074, Würzburg, Germany.
Purpose: Dried blot spot (DBS) analysis of drugs or clinical parameters offers many advantages. We investigated the feasibility of using DBS for analysis of anti-diabetic drugs concomitantly with the estimated creatinine clearance (Cl).
Methods: The cross-sectional study involved physicians in an enabling analysis with 70 diabetic patients and community pharmacists in a field investigation with 84 participants. Read More
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http://dx.doi.org/10.1007/s00228-019-02637-w | DOI Listing |
Eur J Clin Pharmacol 2019 Jan 29. Epub 2019 Jan 29.
Preventive Cardiology and Rehabilitation Unit, DSB 29 "S. Gennaro dei Poveri Hospital", Via S. Gennaro dei Poveri 25, 80136, Naples, Italy.
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http://link.springer.com/10.1007/s00228-019-02638-9 | Publisher Site |
http://dx.doi.org/10.1007/s00228-019-02638-9 | DOI Listing |
Eur J Clin Pharmacol 2019 Jan 29. Epub 2019 Jan 29.
Department of Clinical Pharmacology and Toxicology, University Hospital Zurich-University of Zurich, Rämistrasse 100, 8091, Zurich, Switzerland.
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http://dx.doi.org/10.1007/s00228-019-02635-y | DOI Listing |
Eur J Clin Pharmacol 2019 Jan 29. Epub 2019 Jan 29.
Department of Gastroenterology and Digestive Endoscopy, Mohamed V Military Teaching Hospital of Rabat, Mohamed V University, FAR Avenue, Hay Riad, 10045, Rabat, Morocco.
Aim: To determine the effect of Saccharomyces boulardii CNCM I-745 (S. boulardii) plus sequential therapy on Helicobacter pylori (H. pylori) eradication rate. Read More
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http://link.springer.com/10.1007/s00228-019-02625-0 | Publisher Site |
http://dx.doi.org/10.1007/s00228-019-02625-0 | DOI Listing |
Eur J Clin Pharmacol 2019 Jan 28. Epub 2019 Jan 28.
Department of Pharmacy, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, 410008, Hunan, China.
Purpose: There is a large inter-individual variation in the efficacy of valproic acid (VPA) against epilepsy. The genetic polymorphism influence of sodium channels on VPA response remains a matter of debate. The aim of the study was to explore the effect of SCN1A and SCN2A gene polymorphisms on VPA response in the treatment of epilepsy among Chinese patients. Read More
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http://dx.doi.org/10.1007/s00228-019-02633-0 | DOI Listing |
Eur J Clin Pharmacol 2019 Jan 28. Epub 2019 Jan 28.
Department of Pharmacology, Sahlgrenska Academy, University of Gothenburg, 413 90, Gothenburg, Sweden.
Purpose: To evaluate whether an educational intervention based on collegial discussions on patient cases could increase interns' professional confidence in prescribing.
Methods: In a randomized controlled study at Sahlgrenska University Hospital, Gothenburg, Sweden, 69 interns (median age: 29 years, 54% female) were allocated to an intervention or control group. The intervention consisted of two 3-h seminars based on collegial discussions of patient cases focused on performing medication reviews. Read More
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http://link.springer.com/10.1007/s00228-018-02619-4 | Publisher Site |
http://dx.doi.org/10.1007/s00228-018-02619-4 | DOI Listing |
Eur J Clin Pharmacol 2019 Jan 26. Epub 2019 Jan 26.
Department of Medicine (Geriatrics), University College Cork, Cork University Hospital, Wilton, Cork, T12 DC4A, Ireland.
Purpose: STOPPFrail criteria highlight instances of potentially inappropriate medications (PIMs) in frailer older adults with poor 1-year survival prognosis. The objectives of this study were to (i) determine the proportion of older adults requiring long-term nursing care in whom STOPPFrail criteria are applicable, (ii) measure the prevalence of STOPPFrail PIMs, and (iii) identify risk factors for PIMs in this cohort.
Methods: We retrospectively reviewed applications for long-term nursing care to nursing homes in the Cork area over a 6-month period. Read More
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http://dx.doi.org/10.1007/s00228-019-02630-3 | DOI Listing |
Eur J Clin Pharmacol 2019 Jan 26. Epub 2019 Jan 26.
Institute of Clinical Pharmacology, Medical Faculty Mannheim, Ruprecht-Karls-University Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.
Purpose: Suboptimal drugs therapy is a threat to older people, and listing tools providing guidance are developed to address this problem.
Methods: A systematic review was performed to identify and analyze such tools published until February 2018. A novel categorization was developed to separate patient-in-focus listing approaches (PILA) providing disease-related positive and negative guidance from drug-oriented, mostly negative listing approaches (DOLA, DOLA+: with disease specification). Read More
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http://dx.doi.org/10.1007/s00228-019-02634-z | DOI Listing |
Eur J Clin Pharmacol 2019 Jan 25. Epub 2019 Jan 25.
Department of Pharmacotherapy, Epidemiology and Economics, Groningen Research institute of Pharmacy, University of Groningen, Groningen, The Netherlands.
Purpose: Preparation of parenteral medication in hospitals is a complex process with a risk of microbial contamination of the product, especially when inappropriately prepared. Contaminated parenteral medications can cause severe complications to patients and increase morbidity in hospitals. The aim of this literature review is to systematically evaluate the contamination rate of parenteral medications in hospitals prepared in a pharmacy environment and a clinical environment. Read More
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http://dx.doi.org/10.1007/s00228-019-02631-2 | DOI Listing |
Eur J Clin Pharmacol 2019 Jan 25. Epub 2019 Jan 25.
Merck & Co., Inc., Kenilworth, NJ, USA.
Purpose: To describe the phase 1 and population pharmacokinetic investigations that support dosing recommendations for elbasvir/grazoprevir (EBR/GZR) in hepatitis C virus-infected people with advanced chronic kidney disease.
Methods: This was an open-label, two-part, multiple-dose trial (MK-5172 PN050; NCT01937975) in 24 non-HCV-infected participants with end-stage renal disease (ESRD) or severe renal impairment who received once-daily EBR 50 mg and GZR 100 mg for 10 days. Population pharmacokinetic analyses from the phase 3 C-SURFER study (PN052, NCT02092350) were also conducted. Read More
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http://dx.doi.org/10.1007/s00228-018-2585-3 | DOI Listing |
Eur J Clin Pharmacol 2019 Jan 23. Epub 2019 Jan 23.
Pharmacovigilance and Epidemiology Department, European Medicines Agency, London, UK.
Purpose: There is increasing concern with regard to fatal intoxications with prescription opioids and tramadol poisonings. This study aimed to characterise prescribing patterns for tramadol in primary care in France and Germany and identify long-term treatment and potential risk factors for such treatment.
Methods: Adult patients-prescribed tramadol between January 2006 and June 2016 in GP practices in IMS® Disease Analyzer databases in France and Germany were identified. Read More
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http://dx.doi.org/10.1007/s00228-018-02622-9 | DOI Listing |
Eur J Clin Pharmacol 2019 Jan 21. Epub 2019 Jan 21.
Faculty of Medicine, University of Versailles Saint-Quentin-en-Yvelines, Montigny-le-Bretonneux, France.
Aims: The goal of this study was to analyze persistence and the treatment-free interval in patients being prescribed biological drugs in rheumatology practices in Germany.
Methods: Patients who received a first prescription of biological drugs between 2008 and 2016 in 21 rheumatologists in Germany were included in this study (index date). The main outcome was the rate of persistence with biological drugs as a function of the duration of the treatment-free interval used to define discontinuation. Read More
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http://link.springer.com/10.1007/s00228-019-02627-y | Publisher Site |
http://dx.doi.org/10.1007/s00228-019-02627-y | DOI Listing |
Eur J Clin Pharmacol 2019 Jan 20. Epub 2019 Jan 20.
Vestfold Hospital Trust, Aging and Health, Norwegian Centre for Research, Education and Service Development, Tønsberg, Norway.
Purpose: The purpose of the study is to identify and explore risk factors of serious adverse drug events (SADE) and SADE-related admissions in acutely hospitalized multimorbid older adults and assess whether these could have been prevented by adherence to the prescription tools Screening Tool of Older Persons' Prescriptions (STOPP) and The Norwegian General Practice (NORGEP) criteria.
Methods: Cross-sectional study of acutely admitted patients to a medical department in a Norwegian regional hospital. Eligible patients were community-dwelling, receiving home care services, and aged 75+, with ≥ 3 chronic diseases. Read More
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http://dx.doi.org/10.1007/s00228-019-02624-1 | DOI Listing |
Eur J Clin Pharmacol 2019 Jan 16. Epub 2019 Jan 16.
Servicio de Farmacología Clínica, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), C/ Profesor Martin Lagos s/n, 28040, Madrid, Spain.
Purpose: To evaluate pharmacokinetic parameters of ciprofloxacin in patients undergoing Roux-en-Y gastric surgery (RYGS).
Methods: Controlled, single-dose, open-label study in patients undergoing RYGS. Healthy overweight/obese patients 18-60 years old were included. Read More
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http://dx.doi.org/10.1007/s00228-018-02623-8 | DOI Listing |
Eur J Clin Pharmacol 2019 Jan 15. Epub 2019 Jan 15.
Pediatric Pharmacology and Pharmacometrics, University Children's Hospital Basel UKBB, University of Basel, Spitalstrasse 33, CH 4056, Basel, Switzerland.
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http://dx.doi.org/10.1007/s00228-019-02629-w | DOI Listing |
Eur J Clin Pharmacol 2019 Jan 14. Epub 2019 Jan 14.
Center for Organ Transplantation, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, 197 Ruijin Er Road, Shanghai, 200025, People's Republic of China.
Objectives: Valganciclovir (VGCV) treatment is recommended for the prevention of cytomegalovirus (CMV) infection in renal allograft recipients. The aim of the present study is to investigate the pharmacokinetic characteristics of ganciclovir (GCV) after administration of VGCV in Chinese adult renal allograft recipients and estimate the exposure to GCV using limited sampling strategy (LSS).
Methods: Forty Chinese renal allograft recipients were given 450 mg or 900 mg VGCV daily. Read More
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http://link.springer.com/10.1007/s00228-018-02613-w | Publisher Site |
http://dx.doi.org/10.1007/s00228-018-02613-w | DOI Listing |
Eur J Clin Pharmacol 2019 Jan 9. Epub 2019 Jan 9.
Gestione Ambulatoriale Politerapie (GAP) outpatient clinic, ASST Fatebenefratelli Sacco University Hospital, Milan, Italy.
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http://dx.doi.org/10.1007/s00228-019-02626-z | DOI Listing |
Eur J Clin Pharmacol 2019 Jan 8. Epub 2019 Jan 8.
Hospital Pharmacy, Pescara General Hospital, Pescara, Italy.
Purpose: The aim of this study was to evaluate in what measure is dosage adjustment particularly prevalent in pivotal clinical trials of oral targeted therapy drugs approved by the European Medicine Agency as of July 31, 2018, for the treatment of solid tumors.
Methods: We performed a search on the official EMA site on human medicines, using as Keyword Search the ATC Code L01X (other antineoplastic agents); from the list of drugs results, we subsequently excluded antineoplastic drugs for hematological diseases, as well as refused and withdrawn drugs. For all analyzed drugs, we recorded full dosages, dose adjustments with relative reduction percentage, reason for the adjustments, number of patients included in the trial, percentage of patients who reduced their dosage or temporarily discontinued therapy, cause of dose reduction, and presence or absence of reference to a clinical outcome in patients who reduced their dose or discontinued therapy. Read More
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http://dx.doi.org/10.1007/s00228-018-02621-w | DOI Listing |
Eur J Clin Pharmacol 2019 Jan 6. Epub 2019 Jan 6.
University College of General Medicine and UMR 5558, Laboratoire de Biométrie et Biologie Evolutive, Claude-Bernard Lyon 1 University, CNRS, Lyon, 69622, France.
Purpose: To assess the efficacy of acetylleucine to improve or stop an attack of vertigo and dizziness (vertigo/dizziness).
Methods: Systematic review by 2 independent reviewers. Consultation of the Medline, Cochrane and ClinicalTrials. Read More
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http://link.springer.com/10.1007/s00228-018-02617-6 | Publisher Site |
http://dx.doi.org/10.1007/s00228-018-02617-6 | DOI Listing |
Eur J Clin Pharmacol 2019 Jan 5. Epub 2019 Jan 5.
Center for Drug Clinical Research, Shanghai University of Traditional Chinese Medicine, No. 1200 Cailun Road, Shanghai, 201203, China.
Purpose: This study aimed to establish a non-linear mixed effects model to quantitatively analyze the placebo responses of neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD).
Methods: A comprehensive literature search was conducted in public databases. Placebo-controlled randomized AD clinical trials using the neuropsychiatric inventory (NPI) score as the primary or secondary outcome were included. Read More
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http://dx.doi.org/10.1007/s00228-018-02620-x | DOI Listing |
Eur J Clin Pharmacol 2019 Mar 4;75(3):335-342. Epub 2019 Jan 4.
Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, Rämistrasse 100, CH-8091, Zürich, Switzerland.
Purpose: The thiopurines azathioprine and 6-mercaptopurine are frequently used for remission maintenance in patients with inflammatory bowel diseases. However, there are therapy failures, and it is unclear whether clinical and laboratory parameters can be used to predict thiopurine metabolite concentrations (as a surrogate for adequate remission maintenance therapy) and clinical outcome in these patients.
Methods: In this retrospective analysis of clinical routine patient data, multivariate statistical models based on Linear Mixed Models regression and Generalized Estimating Equations logistic regression were developed. Read More
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http://dx.doi.org/10.1007/s00228-018-02616-7 | DOI Listing |
Eur J Clin Pharmacol 2019 Jan 4. Epub 2019 Jan 4.
Department of Environmental Health, Portuguese National Institute of Health, Porto, Portugal.
Introduction: The importance of rational drug therapy is increasing with the aging of the population. Since one of the main reasons for inappropriate drug prescribing is also the "age-blind" approach, which results in ageist practices, this narrative literature review focuses on the description of the main barriers related to insufficient individualization of drug regimens associated with such age-blind approaches.
Methodology: A narrative literature review using the PubMed, WoS, Embase, and Scopus databases was conducted by the EU COST Action IS1402. Read More
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http://dx.doi.org/10.1007/s00228-018-2603-5 | DOI Listing |
Eur J Clin Pharmacol 2019 Jan 4. Epub 2019 Jan 4.
Programa de Pós Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Av. Ipiranga 2752, Porto Alegre, RS, 90610-000, Brazil.
Purpose: Mycophenolic acid is one of the most used immunosuppressive drugs in solid organ transplant treatments in the world. Developing a highly sensitive analytical method to analyse the drug and its metabolites in oral fluid and plasma is important to evaluate the possibility of using oral fluid as a biological matrix in therapeutic drug monitoring, instead of plasma.
Method: The liquid chromatography coupled to mass spectrometry (LC-MS) method was developed and validated for determining mycophenolic acid (MPA) and its glucuronide metabolite (MPAG) in oral fluid and plasma, with both matrices presenting a detection limit of 1 ng/mL for MPA and 5 ng/mL for MPAG. Read More
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http://dx.doi.org/10.1007/s00228-018-02614-9 | DOI Listing |
Eur J Clin Pharmacol 2019 Jan 4. Epub 2019 Jan 4.
Wolfson Centre for Palliative Care Research, Hull York Medical School, University of Hull, Hull, UK.
Purpose: Older people with dementia are at risk of adverse events associated with potentially inappropriate prescribing.
Aim: to describe (1) how international tools designed to identify potentially inappropriate prescribing have been used in studies of older people with dementia, (2) the prevalence of potentially inappropriate prescribing in this cohort and (3) advantages/disadvantages of tools METHODS: Systematic literature review, designed and reported according to the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P). MEDLINE, EMBASE, PsychInfo, CINAHL, the Cochrane Library, the Social Science Citation Index, OpenGrey, Base, GreyLit, Mednar and the National Database of Ageing Research were searched in April 2016 for studies describing the use of a tool or criteria to identify potentially inappropriate prescribing in older people with dementia. Read More
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http://dx.doi.org/10.1007/s00228-018-02612-x | DOI Listing |
Eur J Clin Pharmacol 2019 Jan 4. Epub 2019 Jan 4.
Department of Hospital Pharmacy, Clínica Universidad de Navarra, Pío XII 36, Pamplona, Spain.
Purpose: Irinotecan (CPT-11) is a drug used against a wide range of tumor types. The individualized dosing of CPT-11 is essential to ensure optimal pharmacotherapy in cancer patients, given the wide interindividual pharmacokinetic variability of this drug and its active metabolite SN-38. Moreover, the reabsorption from SN-38-G to SN-38, by enterohepatic recirculation, is critical due to its influence in the treatment tolerance. Read More
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http://link.springer.com/10.1007/s00228-018-02609-6 | Publisher Site |
http://dx.doi.org/10.1007/s00228-018-02609-6 | DOI Listing |
Eur J Clin Pharmacol 2019 Jan 4. Epub 2019 Jan 4.
Department of General Medicine, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth (Deemed-to-be University), Puducherry, India.
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http://dx.doi.org/10.1007/s00228-018-02618-5 | DOI Listing |
Eur J Clin Pharmacol 2018 Dec 31. Epub 2018 Dec 31.
Department of Clinical Pharmacology, St. Olav University Hospital, Trondheim, Norway.
Purpose: The objective of this study was to examine the impact of an academic detailing programme in primary care in Norway on the prescribing rate of diclofenac, naproxen and non-steroidal anti-inflammatory drugs (NSAIDs) in total.
Methods: An academic detailing programme was delivered to general practitioners (GPs) in two Norwegian cities. The key message was to avoid diclofenac and COX-2 inhibitors and to use naproxen as the NSAID of choice. Read More
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http://dx.doi.org/10.1007/s00228-018-02611-y | DOI Listing |
Eur J Clin Pharmacol 2018 Dec 19. Epub 2018 Dec 19.
Richmond Pharmacology, St George's University, Cranmer Terrace, London, SW17 0RE, UK.
Purpose: Stopping rules are an essential part of risk management in early phase clinical trials. As well as being necessary for ensuring the safety of participants on clinical trials, they are also a requirement under the revision to the European Medicine Agency's first-in-human and early clinical trial guideline. The increasing complexity and size of modern trial designs (e. Read More
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http://link.springer.com/10.1007/s00228-018-02607-8 | Publisher Site |
http://dx.doi.org/10.1007/s00228-018-02607-8 | DOI Listing |
Eur J Clin Pharmacol 2018 Dec 19. Epub 2018 Dec 19.
National Institution of Drug Clinical Trial, Subei People's Hospital, Yangzhou, Jiangsu, China.
Purpose: Prospective prediction of pharmacokinetic properties for individuals of different ethnic groups could provide useful information for the design of multiregional clinical trials. The accuracy of interethnic scaling of fraction unbound (f) of a drug could determine in large part the predictive capability of volume of distribution as well as renal clearance. As such, exploring the interethnic extrapolation of f from healthy Caucasian to Chinese subjects and associated effect on the scaling of volume of distribution is highly warranted. Read More
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http://dx.doi.org/10.1007/s00228-018-02610-z | DOI Listing |
Eur J Clin Pharmacol 2018 Dec 19. Epub 2018 Dec 19.
School of Pharmacy, RCSI, St. Stephen's Green, Dublin 2, Ireland.
Purpose: This study aims to estimate (i) the prevalence of potentially serious alcohol-medication interactions in a nationally representative sample of older adults using the Potentially Serious Alcohol-Medication Interactions in Older adults (POSAMINO) criteria, and (ii) whether POSAMINO prevalence changes over time.
Methods: A prospective cohort study of adults aged ≥ 65 years, using data from the first three waves of The Irish Longitudinal Study on Ageing (TILDA). All 38 POSAMINO criteria were applied at each wave using respondents' information on regular medications and alcohol consumption. Read More
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http://link.springer.com/10.1007/s00228-018-02608-7 | Publisher Site |
http://dx.doi.org/10.1007/s00228-018-02608-7 | DOI Listing |
Eur J Clin Pharmacol 2018 Dec 15. Epub 2018 Dec 15.
Département de Psychiatrie et de Médecine Addictologique, AP-HP, HUSLS-LRB-FWD, Paris, France.
Purpose: Lithium (Li), the first-line treatment of bipolar disorder, was first developed as an immediate-release form with a routine therapeutic drug monitoring 12 h after the last dose. In Europe, the most commonly prescribed form is a sustained release (srLi). Yet no pharmacokinetics (PK) study has been published of srLi, administered once a day, in adults. Read More
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http://link.springer.com/10.1007/s00228-018-2605-3 | Publisher Site |
http://dx.doi.org/10.1007/s00228-018-2605-3 | DOI Listing |
Eur J Clin Pharmacol 2018 Dec 15. Epub 2018 Dec 15.
Department of Emergency Internal Medicine, The First Affiliated Hospital of Bengbu Medical College, Bengbu, 233004, China.
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http://dx.doi.org/10.1007/s00228-018-02606-9 | DOI Listing |
Eur J Clin Pharmacol 2019 Feb 12;75(2):179-187. Epub 2018 Dec 12.
Department of Pharmacy, Groupement Hospitalier Sud, Hospices Civils de Lyon, 165 Chemin du Grand Revoyet, 69495, Pierre Bénite, France.
Purpose: Physicochemical incompatibility (PCI) between drugs infused together is frequent, but under-recognized. PCI can lead to drug inactivity, catheter occlusion, embolism or inflammatory reactions. The aims of this work were to identify most frequent and relevant drug incompatibilities and to review and develop strategies for their prevention. Read More
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http://dx.doi.org/10.1007/s00228-018-2602-6 | DOI Listing |
Eur J Clin Pharmacol 2018 Dec 4. Epub 2018 Dec 4.
Faculty of Health and Medical Sciences, Harry Perkins Research Institute, Fiona Stanley Hospital, University of Western Australia, PO Box 404, Bull Creek 6149, Murdoch, Western Australia, Australia.
Purpose: Ertapenem is used off-label to treat osteoarticular infections but there are few pharmacokinetic (PK) data to guide optimal dosing strategies in patients who may be obese with multiple co-morbidities including diabetes and peripheral vascular disease.
Methods: Participants undergoing lower limb amputation or elective joint arthroplasty received a dose of intravenous ertapenem prior to surgery. Eight plasma samples were collected over 24 h, together with at least one bone sample per patient. Read More
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http://link.springer.com/10.1007/s00228-018-2597-z | Publisher Site |
http://dx.doi.org/10.1007/s00228-018-2597-z | DOI Listing |
Eur J Clin Pharmacol 2018 Dec 3. Epub 2018 Dec 3.
Department of Clinical Pharmacy, Shenyang Pharmaceutical University, No. 103 Wenhua Road, Shenyang, 110016, People's Republic of China.
Purpose: Our aim was to assess the efficacy of metformin for weight loss in overweight and obese people through a systematic review and network meta-analysis and to identify the most suitable dosage and intervention period for using metformin in adolescents and adults.
Methods: We searched databases for studies published by April 2018. A total of 34 trials (44 analyses) involving 8461 participants and 16 intervention arms were eligible. Read More
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http://dx.doi.org/10.1007/s00228-018-2593-3 | DOI Listing |
Eur J Clin Pharmacol 2018 Nov 27. Epub 2018 Nov 27.
Department of Pharmacy, Children's Hospital of Nanjing Medical University, Nanjing, China.
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http://dx.doi.org/10.1007/s00228-018-2604-4 | DOI Listing |
Eur J Clin Pharmacol 2018 Nov 23. Epub 2018 Nov 23.
Unit of Medicines and Health Technologies (MT); Dep. of Health Systems and Services (HSS), Pan American Health Organization (PAHO/WHO), 525 23rd St NW, Washington DC, 20037, USA.
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http://dx.doi.org/10.1007/s00228-018-2587-1 | DOI Listing |