292,644 results match your criteria European Journal of Cardiovascular Nursing [Journal]


The role of histone deacetylase inhibitors in metastatic breast cancer.

Breast 2018 Dec 6;43:130-134. Epub 2018 Dec 6.

IEO, European Institute of Oncology IRCCS, Milan, Italy; Department of Oncology and Hematology, University of Milano, Milan, Italy. Electronic address:

Histone deacetylase inhibitors (HDACi) are a relatively new class of drug that plays an important role in the epigenetic and non-epigenetic regulation in cancer, inducing death, apoptosis and cell cycle arrest in cancer cells. Although HDACi are approved only for hematologic malignancies, there are several trials in the breast cancer setting with promising results. In this review, we summarize the latest studies with HDACi in breast cancer from the emerging data in the translational research until its possible applicability in the clinical practice. Read More

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December 2018

Intestinal parasites and lungworms in stray, shelter and privately owned cats of Switzerland.

Parasitol Int 2018 Dec 12. Epub 2018 Dec 12.

University of Zurich, Vetsuisse Faculty, Institute of Parasitology, Winterthurerstrasse 266a, 8057 Zurich, Switzerland. Electronic address:

Endoparasitic infections represent relevant causes of respiratory and gastrointestinal diseases in cats. The aim of the study was to investigate the occurrence of endoparasites in Swiss cats in order to evaluate the risk of onset of parasitic diseases and potential correlated zoonoses. Therefore 664 faecal samples from privately owned (n = 299), shelter (n = 197) and stray (n = 168) cats were investigated by sedimentation-flotation and 468 samples additionally by the Baermann technique. Read More

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December 2018

Epidemiology and Effects of Bacterial Infections in Patients With Cirrhosis Worldwide.

Gastroenterology 2018 Dec 12. Epub 2018 Dec 12.

Unit of Internal Medicine and Hepatology (UIMH), Department of Medicine - DIMED, University of Padova, Padova, Italy. Electronic address:

Background And Aims: Bacterial infections are common and life-threatening in patients with cirrhosis. Little is known about the epidemiology of bacterial infections in different regions. We performed a multicenter prospective intercontinental study to assess the prevalence and outcomes of bacterial and fungal infections in patients with cirrhosis. Read More

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December 2018
16.716 Impact Factor

A community outbreak of Legionnaires' disease in Geneva, Switzerland, June to September 2017.

Swiss Med Wkly 2018 Nov 2;148:w14687. Epub 2018 Dec 2.

Laboratory of Virology, Division of Laboratory Medicine and Division of Infectious Diseases, University of Geneva Hospitals, Switzerland; University of Geneva Medical School, Switzerland.

Purpose: Eight confirmed cases of Legionnaires’ disease were identified at the Geneva University Hospitals between 28 July 2017 and 02 August 2017, leading to a detailed outbreak investigation.

Methods: Legionnaires’ disease cases were defined according to Swiss and European (ELDSNet) consensus guidelines. An outbreak investigation task force was put in place. Read More

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November 2018

Expression of CD44, EGFR, p16, and their mutual combinations in patients with head and neck cancer: Impact on outcomes of intensity-modulated radiation therapy.

Head Neck 2018 Dec 15. Epub 2018 Dec 15.

Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Brno, Czech Republic.

Background: Progress in radiation treatment of head and neck squamous cell carcinoma (HNSCC) deserves the studies focused on molecular predictors that would help to enhance individually tailored treatment.

Methods: p16/epidermal growth factor receptor (EGFR)/cluster of differentiation-44 (CD44) was immunohistochemically analyzed in 165 HNSCC patients.

Results: In the entire group and the p16 negative cohort, better 3-year overall survival and locoregional control correlated with p16 positivity, CD44, and EGFR negativity were observed. Read More

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December 2018

Tobacco smoking, alcohol drinking, betel quid chewing, and the risk of head and neck cancer in an East Asian population.

Head Neck 2018 Dec 15. Epub 2018 Dec 15.

Division of Public Health, Department of Family and Preventive Medicine, and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah.

Background: The smoking prevalence among men in China is high, but the head and neck cancer incidence rates are low. This study's purpose was to investigate the impact of tobacco, betel quid, and alcohol on head and neck cancer risk in East Asia.

Methods: A multicenter case-control study (921 patients with head and neck cancer and 806 controls) in East Asia was conducted. Read More

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December 2018

Cancer survivorship: an integral part of Europe's research agenda.

Mol Oncol 2018 Dec 15. Epub 2018 Dec 15.

Huntsman Cancer Institute, Salt Lake City, Utah, USA.

Cancer survivorship has traditionally received little prioritisation and attention. For a long time, the treatment of cancer has been the main focus of healthcare providers' efforts. It is time to increase the amount of attention given to patients' long-term well-being and their ability to return to a productive and good life. Read More

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December 2018

Cross-country evidence on the social determinants of the post-socialist mortality crisis in Europe: a review and performance-based hierarchy of variables.

Sociol Health Illn 2018 Dec 14. Epub 2018 Dec 14.

Department of Economics, University of Massachusetts, USA.

An unprecedented mortality crisis befell the former socialist countries between 1989 and 1995, representing one of the greatest demographic shocks of the period after the Second World War. While it is likely that country-level variation in the post-socialist mortality crisis in Eastern Europe can be explained by a constellation of political and socio-economic factors, no comprehensive review of the existing scholarly attempts at explaining these factors exists. We review 39 cross-national multi-variable peer reviewed studies of social determinants of mortality in post-socialist Europe in order to assess the social factors behind the post-socialist mortality crisis, determine the gaps in the existing literature and to make suggestions for future research. Read More

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December 2018

Sympatric diploid and tetraploid cytotypes of Centaurea stoebe s.l. do not differ in arbuscular mycorrhizal communities and mycorrhizal growth response.

Am J Bot 2018 Dec 14. Epub 2018 Dec 14.

Department of Botany, Faculty of Science, Charles University, Benátská 2, CZ-128 01, Prague, Czech Republic.

Premise Of The Study: Genome duplication is associated with multiple changes at different levels, including interactions with pollinators and herbivores. Yet little is known whether polyploidy may also shape belowground interactions.

Methods: To elucidate potential ploidy-specific interactions with arbuscular mycorrhizal fungi (AMF), we compared mycorrhizal colonization and assembly of AMF communities in roots of diploid and tetraploid Centaurea stoebe s. Read More

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December 2018

Barriers and facilitators to understanding of ADHD in primary care: a mixed-method systematic review.

Eur Child Adolesc Psychiatry 2018 Dec 14. Epub 2018 Dec 14.

Division of Psychiatry & Applied Psychology, University of Nottingham, Nottingham, UK.

Attention deficit hyperactivity disorder (ADHD) is a developmental disorder affecting up to 5% of children and adults and is underdiagnosed in many European countries. The process of access to care for this disorder is complex and variable across countries. In general, those affected, or their caregiver, will seek help through their primary care practitioners who are then often responsible for referral to other professionals for diagnosis and provision of treatment. Read More

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December 2018

Growth plate alterations in chronic kidney disease.

Pediatr Nephrol 2018 Dec 14. Epub 2018 Dec 14.

Division of Pediatrics, Department of Medicine, Faculty of Medicine, University of Oviedo, CP 33006, Oviedo, Asturias, Spain.

Growth retardation is a major feature of chronic kidney disease (CKD) of onset in infants or children and is associated with increased morbidity and mortality. Several factors have been shown to play a causal role in the growth impairment of CKD. All these factors interfere with growth by disturbing the normal physiology of the growth plate of long bones. Read More

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December 2018
1 Read

The influence of age on the psychological profile of patients with cardiac implantable electronic devices: results from the Italian population in a multicenter study conducted by the European Heart Rhythm Association.

Aging Clin Exp Res 2018 Dec 14. Epub 2018 Dec 14.

Department of Electrophysiology, Heart Center of Leipzig, Leipzig, Germany.

Background: Cardiac implantable electronic devices (CIEDs) are widely used to treat bradyarrhythmias or improve the prognosis of patients with heart failure (HF).

Aims: To evaluate age-related (≤ 75 vs. > 75 years) attitudes, worries, psychological effects and needs in an Italian CIEDs population. Read More

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December 2018

Characteristics and outcomes of patients ≤ 75 years who underwent transcatheter aortic valve implantation: insights from the SOURCE 3 Registry.

Clin Res Cardiol 2018 Dec 14. Epub 2018 Dec 14.

Division of Adult Congenital and Valvular Heart Disease, Department of Cardiovascular Medicine, University Hospital Muenster, Muenster, Germany.

Background: Current trials and registries of transcatheter valve implantation (TAVI) mostly include patients older than 75 years. Little is known about younger patients who undergo this treatment. We investigated comorbidities among patients < 75 years old who underwent TAVI in the SAPIEN 3™ European post-approval SOURCE 3 Registry, and analysed outcomes at 30 days and 1 year. Read More

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December 2018

Arc of Bühler: the surgical significance of a rare anatomical variation.

Surg Radiol Anat 2018 Dec 14. Epub 2018 Dec 14.

Department of Anatomy and Surgical Anatomy, School of Medicine, National and Kapodistrian University of Athens, Tetrapoleos 18, 75 Mikras Asias Str, 11527, Athens, Greece.

Purpose: The arc of Bühler, an anastomotic vessel between celiac artery and superior mesenteric artery, is a rare anatomic variation. Various radiologic and surgical procedures can be affected by its existence. We aim to review all available information and identify possible clinical implications. Read More

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December 2018

[Radiological imaging to assess individual cardiovascular risk].

Radiologe 2018 Dec 14. Epub 2018 Dec 14.

Klinik für Diagnostische und Interventionelle Radiologie und Neuroradiologie, Klinikum Augsburg, Stenglinstr. 2, 86156, Augsburg, Deutschland.

Clinical/methodical Issue: Radiologic imaging for the assessment of individual cardiovascular risk.

Standard Radiological Methods: The correct estimation of the individual cardiovascular risk is prerequisite for the prevention of cardiovascular diseases. Here, extensive evidence is available for coronary calcium scans as well as coronary CT angiography (CTA). Read More

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December 2018

Longitudinal airway remodeling in active and past smokers in a lung cancer screening population.

Eur Radiol 2018 Dec 14. Epub 2018 Dec 14.

Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany.

Objectives: To longitudinally investigate smoking cessation-related changes of quantitative computed tomography (QCT)-based airway metrics in a group of heavy smokers.

Methods: CT scans were acquired in a lung cancer screening population over 4 years at 12-month intervals in 284 long-term ex-smokers (ES), 405 continuously active smokers (CS), and 31 subjects who quitted smoking within 2 years after baseline CT (recent quitters, RQ). Total diameter (TD), lumen area (LA), and wall percentage (WP) of 1st-8th generation airways were computed using airway analysis software. Read More

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December 2018

On the role of eye contact in gaze cueing.

Sci Rep 2018 Dec 14;8(1):17842. Epub 2018 Dec 14.

Istituto Italiano di Tecnologia, Social Cognition in Human-Robot Interaction, via Enrico Melen 83, 16152, Genova, Italy.

Most experimental protocols examining joint attention with the gaze cueing paradigm are "observational" and "offline", thereby not involving social interaction. We examined whether within a naturalistic online interaction, real-time eye contact influences the gaze cueing effect (GCE). We embedded gaze cueing in an interactive protocol with the iCub humanoid robot. Read More

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December 2018

Nucleus-specific X-ray stain for 3D virtual histology.

Sci Rep 2018 Dec 14;8(1):17855. Epub 2018 Dec 14.

Department of Physics and Munich School of BioEngineering, Technical University of Munich, 85748, Garching, Germany.

Histological investigations are indispensable with regards to the identification of structural tissue details but are limited to two-dimensional images, which are often visualized in one and the same plane for comparison reasons. Nondestructive three-dimensional technologies such as X-ray micro- and nanoCT have proven to provide valuable benefits for the understanding of anatomical structures as they allow visualization of structural details in 3D and from arbitrary viewing angles. Nevertheless, low attenuation of soft tissue has hampered their application in the field of 3D virtual histology. Read More

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December 2018

A novel Lab-on-Fiber Radiation Dosimeter for Ultra-high Dose Monitoring.

Sci Rep 2018 Dec 14;8(1):17841. Epub 2018 Dec 14.

Optoelectronics Group - Department of Engineering, University of Sannio, I-82100, Benevento, Italy.

In this work, we report on the first demonstration of Lab on Fiber (LOF) dosimeter for ionizing radiation monitoring at ultra-high doses. The new dosimeter consists in a metallo-dielectric resonator at sub-wavelength scale supporting localized surface plasmon resonances realized on the optical fiber (OF) tip. The resonating structure involves two gold gratings separated by a templated dielectric layer of poly(methyl methacrylate) (PMMA). Read More

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December 2018

Exploratory genome-wide association analysis of response to ketamine and a polygenic analysis of response to scopolamine in depression.

Transl Psychiatry 2018 Dec 14;8(1):280. Epub 2018 Dec 14.

Statistical Genomics and Data Analysis Core, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.

Growing evidence suggests that the glutamatergic modulator ketamine has rapid antidepressant effects in treatment-resistant depressed subjects. The anticholinergic agent scopolamine has also shown promise as a rapid-acting antidepressant. This study applied genome-wide markers to investigate the role of genetic variants in predicting acute antidepressant response to both agents. Read More

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December 2018

Evidence for a southward autumn migration of nocturnal noctuid moths in central Europe.

J Exp Biol 2018 Dec 14;221(Pt 24). Epub 2018 Dec 14.

Department of Biology, Lund University, 22362 Lund, Sweden.

Insect migrations are spectacular natural events and resemble a remarkable relocation of biomass between two locations in space. Unlike the well-known migrations of daytime flying butterflies, such as the painted lady () or the monarch butterfly (), much less widely known are the migrations of nocturnal moths. These migrations - typically involving billions of moths from different taxa - have recently attracted considerable scientific attention. Read More

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December 2018

Epigenetic regulation of Dlg1, via Kaiso, alters mitotic spindle polarity and promotes intestinal tumourigenesis.

Mol Cancer Res 2018 Dec 14. Epub 2018 Dec 14.

European Cancer Stem Cell Research Institute, School of Biosciences, Cardiff University

Both alterations to the epigenome and loss of polarity have been linked to cancer initiation, progression and metastasis. It has previously been demonstrated that loss of the epigenetic reader protein Kaiso suppresses intestinal tumourigenesis in the Apc+/min mouse model, in which altered polarity plays a key role. Thus, we investigated the link between Kaiso deficiency, polarity and suppression of intestinal tumourigenesis. Read More

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December 2018

Impact of Ga-PSMA-PET/CT on the radiotherapeutic approach for prostate cancer in comparison to CT - a retrospective analysis.

J Nucl Med 2018 Dec 14. Epub 2018 Dec 14.

Ludwig-Maximilians-University (LMU), Germany.

Gallium-prostate-specific membrane antigen positron emission tomography/computed tomography (Ga-PSMA PET/CT) offers unprecedented accuracy for staging of primary, persistent or recurrent prostate cancer. Thus, we hypothesized that PSMA PET/CT prior to radiotherapy significantly impacts the radiotherapeutic approach in comparison to the current standard of CT based approach. Between February 2014 and December 2017, a total of 172 patients received PSMA PET/CT before radiotherapy and were included in this retrospective analysis. Read More

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December 2018

Patient-Reported Outcomes with PD-1/PD-L1 Inhibitors for Advanced Cancer: A Meta-Analysis.

Oncologist 2018 Dec 14. Epub 2018 Dec 14.

General Medical Research Center, Faculty of Medicine, Fukuoka University, Japan.

Background: The aim of this meta-analysis was to compare patient-reported outcomes (PROs) between programmed death receptor-1/programmed death-ligand 1 (PD-1/PD-L1) inhibitors and standard-of-care therapy in patients with advanced cancer.

Methods: We searched randomized controlled trials (RCTs) comparing single-agent PD-1/PD-L1 inhibitors (nivolumab, pembrolizumab, atezolizumab, avelumab, or durvalumab) with standard-of-care therapy in patients with advanced cancer reporting PROs with generic measures: the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 items (QLQ-C30) and the EuroQol Five Dimensions Questionnaire. The summary outcomes were changes in PROs from baseline to follow-up within and between treatment groups and time to deterioration (TTD) in PROs based on clinically meaningful change. Read More

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December 2018

Truxima Gets High Marks from Physicians.

Authors:

Cancer Discov 2018 Dec 14. Epub 2018 Dec 14.

Doctors are convinced that Truxima, the first rituximab biosimilar approved by the FDA, is as effective as rituximab; European experience with the biosimilar over the last 2 years has also revealed no problems with unexpected side effects. However, cost will be a factor in determining whether doctors in the United States prescribe Truxima instead of rituximab. Read More

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December 2018

Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study.

Lancet Respir Med 2018 Dec 11. Epub 2018 Dec 11.

Division of Respiratory Medicine, National Institute for Health Research, Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK. Electronic address:

Background: Few genetic studies that focus on moderate-to-severe asthma exist. We aimed to identity novel genetic variants associated with moderate-to-severe asthma, see whether previously identified genetic variants for all types of asthma contribute to moderate-to-severe asthma, and provide novel mechanistic insights using expression analyses in patients with asthma.

Methods: In this genome-wide association study, we used a two-stage case-control design. Read More

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December 2018

Urban blue space and health and wellbeing in Hong Kong: Results from a survey of older adults.

Health Place 2018 Dec 10. Epub 2018 Dec 10.

JC School of Public Health and Primary Care, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong. Electronic address:

The potential benefits of aquatic environments for public health have been understudied in Asia. We investigated the relationships between blue space exposures and health outcomes among a sample of predominantly older adults in Hong Kong. Those with a view of blue space from the home were more likely to report good general health, while intentional exposure was linked to greater odds of high wellbeing. Read More

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December 2018
2.805 Impact Factor

Prevalence of Known Risk Factors for Type 2 Diabetes Mellitus in Multiethnic Urban Youth in Edmonton: Findings From the WHY ACT NOW Project.

Can J Diabetes 2018 Oct 9. Epub 2018 Oct 9.

Indigenous and Global Health Research Group, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

Objectives: The Canadian Diabetes Risk Assessment Questionnaire (CANRISK) is a validated, evidence-based, self-administered tool to assess the risk for type 2 diabetes mellitus in multiethnic Canadian adults. Identifying individuals at high risk for type 2 diabetes allows early intervention that improves modifiable risk factors. This study examined the risk factors for type 2 diabetes in multiethnic urban youth in Edmonton, Alberta. Read More

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October 2018

Integrated Care Management of Patients With Atrial Fibrillation and Risk of Cardiovascular Events: The ABC (Atrial fibrillation Better Care) Pathway in the ATHERO-AF Study Cohort.

Mayo Clin Proc 2018 Dec 11. Epub 2018 Dec 11.

Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, United Kingdom; Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Denmark. Electronic address:

Objective: To investigate the impact on cardiovascular events (CVEs) in a real-world population of patients with atrial fibrillation (AF) by implementing the Atrial fibrillation Better Care (ABC: A, Avoid stroke with anticoagulation; B, better symptom management; C, Cardiovascular and comorbidity risk management) pathway.

Patients And Methods: This prospective single-center cohort study included 907 consecutive patients with nonvalvular AF on vitamin K antagonists from February 2008 to December 2016. The A, B, and C groups were defined as follows: "A" by a Time in Therapeutic Range ≥65%; "B" by a European Heart Rhythm Association (EHRA) symptom scale I-II, and "C" as optimized cardiovascular comorbidity management. Read More

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December 2018

Malnutrition according to ESPEN definition predicts long-term mortality in general older population: Findings from the EPIDOS study-Toulouse cohort.

Clin Nutr 2018 Dec 1. Epub 2018 Dec 1.

Department of Neurosciences and Aging, Division of Geriatric Medicine, Angers University Hospital, Angers University Memory Clinic, Research Center on Autonomy and Longevity, UPRES EA 4638, University of Angers, UNAM, Angers, France; Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.

Background: The European Society of Clinical Nutrition and Metabolism (ESPEN) has developed a consensus definition of malnutrition. This study aimed to determine the prevalence of malnutrition according to the ESPEN definition in otherwise healthy community-dwelling older women and to explore its value for predicting long-term mortality in this population.

Methods: This prospective population-based cohort study included 181 women (age ≥75 years) from a subsample of the EPIDémiologie de l'OStéoporose (EPIDOS) study participants from Toulouse. Read More

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December 2018

Cost-effectiveness analysis of total elbow arthroplasty versus open reduction-internal fixation for distal humeral fractures.

J Shoulder Elbow Surg 2019 Jan;28(1):102-111

Division of Sports Medicine, Midwest Orthopaedics at Rush, Rush University Medical Center, Chicago, IL, USA.

Background: Total elbow arthroplasty (TEA) and open reduction-internal fixation (ORIF) are 2 viable surgical treatment options for acute, intra-articular distal humeral fractures in elderly patients. Whereas recent systematic reviews and randomized trials have suggested that TEA and ORIF result in similar functional outcome scores, no previous study has assessed the comparative cost-effectiveness between TEA and distal humeral ORIF in this specific demographic.

Methods: A Markov model was created with the highest-level data available from the literature depicting transitioning health states based on treatment strategies. Read More

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January 2019

Frailty as the Future Core Business of Public Health: Report of the Activities of the A3 Action Group of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA).

Int J Environ Res Public Health 2018 Dec 13;15(12). Epub 2018 Dec 13.

Department of Biomedicine and Prevention, University of Rome "Tor Vergata", 00133 Rome, Italy.

The prevalence of frailty at population-level is expected to increase in Europe, changing the focus of Public Health. Here, we report on the activities of the A3 Action Group, focusing on managing frailty and supporting healthy ageing at community level. A three-phased search strategy was used to select papers published between January 2016 and May 2018. Read More

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December 2018

Drug-Loaded Biomimetic Ceramics for Tissue Engineering.

Pharmaceutics 2018 Dec 13;10(4). Epub 2018 Dec 13.

Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.

The mimesis of biological systems has been demonstrated to be an adequate approach to obtain tissue engineering scaffolds able to promote cell attachment, proliferation, and differentiation abilities similar to those of autologous tissues. Bioceramics are commonly used for this purpose due to their similarities to the mineral component of hard tissues as bone. Furthermore, biomimetic scaffolds are frequently loaded with diverse therapeutic molecules to enhance their biological performance, leading to final products with advanced functionalities. Read More

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December 2018

Applications of Noble Metal-Based Nanoparticles in Medicine.

Int J Mol Sci 2018 Dec 13;19(12). Epub 2018 Dec 13.

Department of Clinical Immunology, Institute of Paediatrics, Jagiellonian University, Medical College, 30-663 Krakow, Poland.

Nanoparticles have unique, size-dependent properties, which means they are widely used in various branches of industry. The ability to control the properties of nanoparticles makes these nanomaterials very interesting for medicine and pharmacology. The application of nanoparticles in medicine is associated with the design of specific nanostructures, which can be used as novel diagnostic and therapeutic modalities. Read More

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December 2018

Use of the Wilshire Equations to Correlate and Extrapolate Creep Data of Inconel 617 and Nimonic 105.

Materials (Basel) 2018 Dec 13;11(12). Epub 2018 Dec 13.

KeyLogic Systems, Inc., 3168 Collins Ferry Road, Morgantown, WV 26505, USA.

Advanced power plant alloys must endure high temperatures and pressures for durations at which creep data are often not available, necessitating the extrapolation of creep life. A recently developed creep life extrapolation method is the Wilshire equations, with which multiple approaches can be used to increase the goodness of fit of available experimental data and improve the confidence level of calculating long-term creep strength at times well beyond the available experimental data. In this article, the Wilshire equation is used to extrapolate the creep life of Inconel 617 and Nimonic 105 to 100,000 h. Read More

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December 2018

Barriers from Multiple Perspectives Towards Physical Activity, Sedentary Behaviour, Physical Activity and Dietary Habits When Living in Low Socio-Economic Areas in Europe. The Feel4Diabetes Study.

Int J Environ Res Public Health 2018 Dec 13;15(12). Epub 2018 Dec 13.

Department of Movement and Sports Sciences, Ghent University, 9000 Ghent, Belgium.

This study investigated barriers towards health behaviours (physical activity, limiting sedentary behaviour and healthy dietary habits) experienced by young European families living in vulnerable areas, from multiple perspectives (parents, teachers, local community workers). Focus groups were conducted in six European countries (Belgium, Bulgaria, Finland, Hungary, Greece and Spain). In each country, three focus groups were conducted with parents, one with teachers and one with local community workers. Read More

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December 2018

3D Imaging of Indentation Damage in Bone.

Materials (Basel) 2018 Dec 13;11(12). Epub 2018 Dec 13.

Henry Moseley X-ray Imaging Facility, Henry Royce Institute, School of Materials, The University of Manchester, Manchester M13 9PL, UK.

Bone is a complex material comprising high stiffness, but brittle, crystalline bio-apatite combined with compliant, but tough, collagen fibres. It can accommodate significant deformation, and the bone microstructure inhibits crack propagation such that micro-cracks can be quickly repaired. Catastrophic failure (bone fracture) is a major cause of morbidity, particularly in aging populations, either through a succession of small fractures or because a traumatic event is sufficiently large to overcome the individual crack blunting/shielding mechanisms. Read More

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December 2018
1 Read

Hormonal Responses to Infection in Cultivars Differing in Their Pathogen Resistance.

Int J Mol Sci 2018 Dec 13;19(12). Epub 2018 Dec 13.

Institute of Experimental Botany Czech Acad Sci, Laboratory of Hormonal Regulations in Plants, Rozvojova 263, 165 02 Prague 6, Czech Republic.

Hormonal dynamics after infection were compared in two cultivars-more resistant SY Alister and more sensitive Hornet, in order to elucidate responses associated with efficient defense. Both cultivars responded to infection by the early transient elevation of active cytokinins (predominantly -zeatin) and auxin indole-3-acetic acid (IAA) in leaves and roots, which was longer in Hornet. Moderate IAA levels in Hornet roots coincided with a high expression of biosynthetic gene (contrary to , , ). Read More

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December 2018

Protective and reversal actions of a novel peptidomimetic against a pivotal toxin implicated in Alzheimer's disease.

Biomed Pharmacother 2019 Jan 6;109:1052-1061. Epub 2018 Nov 6.

Neuro-Bio Ltd, Culham Science Centre, Building F5, Abingdon, OX14 3DB, UK.

Despite the many attempts to understand the aetiology of Alzheimer's disease, the basic mechanisms accounting for the progressive cycle of neuronal loss are still unknown. Previous work has suggested that the pivotal molecule mediating neurodegeneration could be an independently acting peptide cleaved from acetylcholinesterase. This previously unidentified agent acts as a signalling molecule in selectively vulnerable groups of cells where erstwhile developmental mechanisms are activated inappropriately to have a toxic effect in the context of the mature brain. Read More

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January 2019

Peer counseling in depression care: A pilot study in a psychiatric inpatient setting.

Psychiatry Res 2018 Dec 25;270:698-704. Epub 2018 Oct 25.

Department of Psychiatry and Psychotherapy, University Leipzig, Leipzig, Germany.

To evaluate in a pilot study whether peer counseling is feasible and accepted for inpatients with depression. A one-to-one peer counseling intervention was implemented in an inpatient psychiatric department. Patients were invited to ask questions concerning their illness. Read More

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December 2018

Cereal Lignans, Natural Compounds of Interest for Human Health?.

Nat Prod Commun 2017 Jan;12(1):139-146

Cereals are suggested to be the most important sources of lignan in the diets of western populations. Recent epidemiological studies show that European subpopulations in which the major source of lignans are cereals, display lower disease frequency regarding metabolic and cardiovascular diseases. The biological mechanisms of lignan are several. Read More

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January 2017

Diagnostic leukapheresis for CTC analysis in breast cancer patients: CTC frequency, clinical experiences and recommendations for standardized reporting.

Cytometry A 2018 Dec;93(12):1213-1219

Faculty of the Heinrich-Heine, General, Visceral and Pediatric Surgery, University Hospital and Medical Faculty, University Düsseldorf, Düsseldorf, North Rhine-Westphalia, Germany.

Diagnostic leukapheresis (DLA) is based on continuous centrifugation that collects mononuclear cells from peripheral blood with a density of 1.055-1.08 g/ml. Read More

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December 2018
1 Read

DEPArray™ system: An automatic image-based sorter for isolation of pure circulating tumor cells.

Cytometry A 2018 Dec;93(12):1260-1266

Menarini Silicon Biosystems S.p.A, Bologna, Italy.

Circulating tumor cells (CTCs) are rare cells shed into the bloodstream by invasive tumors and their analysis offers a promising noninvasive tool to predict and monitor therapeutic responses. CTCs can be isolated from patient blood and their characterization at single-cell level can inform on the genomic landscape of a tumor. All CTC enrichment methods bear a burden of contaminating normal cells, which mandate a further step of purification to enable reliable downstream genetic analysis. Read More

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December 2018
1 Read

Polychaete mucopolysaccharide alters sediment microbial diversity and stimulates ammonia-oxidising functional groups.

FEMS Microbiol Ecol 2018 Dec 14. Epub 2018 Dec 14.

Marine Biological Association of the United Kingdom, The Laboratory, Citadel Hill, Plymouth, PL1 2PB.

Sediment nitrogen cycling is a network of microbially-mediated biogeochemical processes that are vital in regulating ecosystem functioning. Mucopolysaccharides (mucus) are produced by many invertebrates and have the potential to be an important source of organic carbon and nitrogen to sediment microorganisms. At present, we have limited understanding of how mucopolysaccharide moderates total sediment microbial communities and specific microbial functional groups that drive nitrogen cycling processes. Read More

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December 2018
1 Read

Renal relapse in antineutrophil cytoplasmic autoantibody-associated vasculitis: unpredictable, but predictive of renal outcome.

Rheumatology (Oxford) 2019 Jan;58(1):103-109

Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.

Objectives: To determine predictors of renal relapse and end-stage renal failure (ESRF) in patients with ANCA-associated vasculitis.

Methods: Data from four European Vasculitis Society randomized controlled trials, conducted roughly simultaneously between 15 March 1995 and 30 September 2002, was pooled to determine predictors of long-term renal outcome. The respective trial inclusion criteria covered the entire spectrum of disease severity. Read More

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January 2019

Measuring mental well-being in Denmark: Validation of the original and short version of the Warwick-Edinburgh mental well-being scale (WEMWBS and SWEMWBS) and cross-cultural comparison across four European settings.

Psychiatry Res 2018 Dec 5;271:502-509. Epub 2018 Dec 5.

The Danish National Institute of Public Health, University of Southern Denmark, Studiestraede 6, 1455 Copenhagen, Denmark. Electronic address:

This study examined the psychometric properties of the Danish WEMWBS and its short version (SWEMWBS) in a Danish population sample, and compared scores in Denmark with scores representative of three other European settings. A total of 3,508 Danish men and women aged 16-95 filled out an electronic survey. Face validity was examined by cognitive interviews. Read More

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December 2018

Targeted and untargeted LC-MS polyphenolic profiling and chemometric analysis of propolis from different regions of Croatia.

J Pharm Biomed Anal 2018 Dec 4;165:162-172. Epub 2018 Dec 4.

University of Rijeka, Department of Biotechnology, Centre for high-throughput technologies, Radmile Matejčić 2, 51000 Rijeka, Croatia. Electronic address:

Propolis is a complex biological matrix consisting mostly of plant resins and waxes, and in a small proportion of the herbal secondary metabolites, phenols. Phenols are components that are responsible for biological activities of propolis, however, their qualitative and quantitative composition is strongly influenced by climate and vegetation. Although studies on profiling of propolis samples from different countries have been carried out for some time propolis from Croatia is still not characterized till now. Read More

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December 2018

Vertico-horizontal atlantoaxial index (VHAI): A new craniovertebral radiographic index.

Clin Neurol Neurosurg 2018 Dec 3;176:83-88. Epub 2018 Dec 3.

Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address:

Objective: The purpose of this study was to develop a new index that can reliably quantify the reduction of basilar invagination with atlantoaxial dislocation.

Patients And Methods: Between May 2012 and September 2017, 40 patients with congenital basilar invagination and atlantoaxial dislocation as well as 100 sex-and age-matched control subjects were recruited for this study. All patients underwent direct posterior reduction and fixation. Read More

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December 2018