631 results match your criteria European Heart Journal: Acute Cardiovascular Care [Journal]


Risk stratification in normotensive acute pulmonary embolism patients: focus on the intermediate-high risk subgroup.

Eur Heart J Acute Cardiovasc Care 2019 Apr 24:2048872619846506. Epub 2019 Apr 24.

2 Cardiology Department, Hospital de Santa Cruz, Portugal.

Background: Patients with acute pulmonary embolism are at intermediate-high risk in the presence of imaging signs of right ventricular dysfunction plus one or more elevated cardiac biomarker. We hypothesised that intermediate-high risk patients with two elevated cardiac biomarkers and imaging signs of right ventricular dysfunction have a worse prognosis than those with one cardiac biomarker and imaging signs of right ventricular dysfunction.

Methods: We analysed the cumulative presence of cardiac biomarkers and imaging signs of right ventricular dysfunction in 525 patients with intermediate risk pulmonary embolism (intermediate-high risk = 237) presenting at the emergency department in two centres. Read More

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http://dx.doi.org/10.1177/2048872619846506DOI Listing

Renal function in myocardial infarction: does serum creatinine tells the whole story?

Eur Heart J Acute Cardiovasc Care 2019 Apr 24:2048872619827827. Epub 2019 Apr 24.

Department of Internal Medicine, UZ Leuven, Belgium.

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http://dx.doi.org/10.1177/2048872619827827DOI Listing

Pentraxin-3 vs C-reactive protein and other prognostic biomarkers in acute coronary syndrome: A substudy of the Platelet Inhibition and Patients Outcomes (PLATO) trial.

Eur Heart J Acute Cardiovasc Care 2019 Apr 24:2048872619846334. Epub 2019 Apr 24.

7 Department of Medical Sciences, Cardiology Uppsala University, Sweden.

Aims: We investigated the dynamics, associations with patient characteristics, other biomarkers, and clinical outcomes of pentraxin 3 in acute coronary syndrome.

Methods And Results: In multivariate analyses, pentraxin 3 measured in 5154 patients randomised in the Platelet Inhibition and Patients Outcomes (PLATO) trial (NCT00391872) was compared with leukocytes, high-sensitivity C-reactive protein, interleukin-6, cystatin C, N-terminal prohormone brain natriuretic peptide, high-sensitivity troponin T and growth differentiation factor 15 concerning prediction of clinical outcome. Pentraxin 3 peaked earlier than high-sensitivity C-reactive protein and was more strongly correlated with N-terminal prohormone brain natriuretic peptide and high-sensitivity troponin T than with high-sensitivity C-reactive protein. Read More

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http://dx.doi.org/10.1177/2048872619846334DOI Listing

Incremental value of high-frequency QRS analysis for diagnosis and prognosis in suspected exercise-induced myocardial ischaemia.

Eur Heart J Acute Cardiovasc Care 2019 Apr 22:2048872619842988. Epub 2019 Apr 22.

1 Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Switzerland.

Aim: Exercise stress testing is used to detect myocardial ischaemia, but is limited by low sensitivity and specificity. The authors investigated the value of the analysis of high-frequency QRS components as a marker of abnormal depolarization in addition to standard ST-deviations as a marker of abnormal repolarization to improve the diagnostic accuracy.

Methods And Results: Consecutive patients undergoing bicycle exercise stress nuclear myocardial perfusion imaging were prospectively enrolled. Read More

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http://dx.doi.org/10.1177/2048872619842988DOI Listing

Proposal for a standardized discharge letter after hospital stay for acute myocardial infarction.

Eur Heart J Acute Cardiovasc Care 2019 Apr 16:2048872619844444. Epub 2019 Apr 16.

11 Service de Cardiologie B, CHU Rangueil, Toulouse, France.

In patients admitted for acute myocardial infarction, the communication and transition from specialists to primary care physicians is often delayed, and the information imparted to subsequent healthcare providers (HCPs) may be sub-optimal. A French group of cardiologists, lipidologists and diabetologists decided to establish a consensus to optimize the discharge letter after hospitalization for acute myocardial infarction. The aim is to improve both the timeframe and the quality of the content transmitted to subsequent HCPs, including information regarding baseline assessment, procedures during hospitalization, residual risk, discharge treatments, therapeutic targets and follow-up recommendations in compliance with European Society of Cardiology guidelines. Read More

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http://dx.doi.org/10.1177/2048872619844444DOI Listing
April 2019
3 Reads

Incremental costs of high intensive care utilisation in patients hospitalised with heart failure.

Eur Heart J Acute Cardiovasc Care 2019 Apr 12:2048872619845282. Epub 2019 Apr 12.

2 Division of Cardiology, University of Alberta, Canada.

Aims: Registries have reported large inter-hospital differences in intensive care unit admission rates for patients with acute heart failure, but little is known about the potential economic impact of over-admission of low-risk patients with heart failure to higher cost intensive care units. We described the variability in intensive care unit admission practices, the provision of critical care therapies, and estimated the potential national cost savings if all hospitals adopted low intensive care unit admission practices for patients admitted with heart failure.

Methods: Using a national population health dataset, we identified 349,693 heart failure admission hospitalisations with a primary diagnosis of heart failure between 2007 and 2016. Read More

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http://dx.doi.org/10.1177/2048872619845282DOI Listing
April 2019
2 Reads

Acute coronary syndromes in insulin treated diabetics, elderly and female patients: remaining gaps in EMS activation, therapy and clinical outcomes.

Eur Heart J Acute Cardiovasc Care 2019 Apr;8(3):199-200

Cardiovascular diseases, University of Antwerp, Belgium.

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http://dx.doi.org/10.1177/2048872619845289DOI Listing

Outcomes of decreasing versus increasing cardiac troponin in patients admitted with non-ST-segment elevation myocardial infarction: the Atherosclerosis Risk in Communities Surveillance Study.

Eur Heart J Acute Cardiovasc Care 2019 Apr 8:2048872619842983. Epub 2019 Apr 8.

1 Division of Cardiology, University of North Carolina at Chapel Hill, USA.

Background: The fourth universal definition of myocardial infarction requires an increase or decrease in cardiac troponin for the classification of non-ST-segment elevation myocardial infarction. We sought to determine whether the characteristics, management, and outcomes of patients admitted with non-ST-segment elevation myocardial infarction differ by the initial biomarker pattern.

Methods: We identified patients in the Atherosclerosis Risk in Communities Surveillance Study admitted with chest pain and an initially elevated cardiac troponin I, who presented within 12 hours of symptom onset and were classified with non-ST-segment elevation myocardial infarction. Read More

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http://dx.doi.org/10.1177/2048872619842983DOI Listing
April 2019
1 Read

Prognostic value of automated pupillometry: an unselected cohort from a cardiac intensive care unit.

Eur Heart J Acute Cardiovasc Care 2019 Apr 5:2048872619842004. Epub 2019 Apr 5.

1 Department of Cardiology, Rigshospitalet - Copenhagen University Hospital, Denmark.

Background:: Patients admitted to a cardiac intensive care unit are often unconscious with uncertain prognosis. Automated infrared pupillometry for neurological assessment in the intensive care unit may provide early prognostic information. This study aimed to determine the prognostic value of automated pupillometry in different subgroups of patients in a cardiac intensive care unit with 30-day mortality as the primary endpoint and neurological outcome as the secondary endpoint. Read More

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http://dx.doi.org/10.1177/2048872619842004DOI Listing
April 2019
3 Reads

Treatment strategies for post-infarction left ventricular free-wall rupture.

Eur Heart J Acute Cardiovasc Care 2019 Apr 1:2048872619840876. Epub 2019 Apr 1.

1 Department of Cardiothoracic Surgery, Heart and Vascular Centre, Maastricht University Medical Centre, The Netherlands.

Left ventricular free-wall rupture is one of the most fatal complications after acute myocardial infarction. Surgical treatment of post-infarction left ventricular free-wall rupture has evolved over time. Direct closure of the ventricular wall defect (linear closure) and resection of the infarcted myocardium (infarctectomy), with subsequent closure of the created defect with a prosthetic patch, represented the original techniques. Read More

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http://dx.doi.org/10.1177/2048872619840876DOI Listing
April 2019
3 Reads

Focus on cardiac arrhythmias and conduction disorders.

Eur Heart J Acute Cardiovasc Care 2019 Mar;8(2):101-103

Cardiovascular diseases, University of Antwerp, Belgium.

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http://journals.sagepub.com/doi/10.1177/2048872619839639
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http://dx.doi.org/10.1177/2048872619839639DOI Listing
March 2019
4 Reads

Mitochondrial dysfunction in adults after out-of-hospital cardiac arrest.

Eur Heart J Acute Cardiovasc Care 2019 Mar 11:2048872618814700. Epub 2019 Mar 11.

4 Center for Healthy Aging, University of Copenhagen, Denmark.

Background:: While preclinical studies suggest that mitochondria play a pivotal role in ischaemia-reperfusion injury, the knowledge of mitochondrial function in human out-of-hospital cardiac arrest remains scarce. The present study sought to compare oxidative phosphorylation capacity in skeletal muscle biopsies from out-of-hospital cardiac arrest patients to healthy controls.

Methods:: This was a substudy of a randomised trial comparing targeted temperature management at 33°C versus 36°C for out-of-hospital cardiac arrest patients. Read More

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http://dx.doi.org/10.1177/2048872618814700DOI Listing
March 2019
1 Read

Early intravenous beta-blockers in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: A patient-pooled meta-analysis of randomized clinical trials.

Eur Heart J Acute Cardiovasc Care 2019 Feb 14:2048872619830609. Epub 2019 Feb 14.

3 Department of Cardiology, Radboud University Medical Center, The Netherlands.

Background:: Conflicting evidence is available on the efficacy and safety of early intravenous beta-blockers before primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. We performed a patient-pooled meta-analysis of trials comparing early intravenous beta-blockers with placebo or routine care in ST-segment elevation myocardial infarction patients undergoing primary percutaneous coronary intervention.

Aim:: The aim of this study was to evaluate the clinical and safety outcomes of intravenous beta-blockers in ST-segment elevation myocardial infarction patients undergoing primary percutaneous coronary intervention. Read More

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http://dx.doi.org/10.1177/2048872619830609DOI Listing
February 2019
3 Reads

Medical Misinformation: Vet the Message!

Authors:
Joseph A Hill

Eur Heart J Acute Cardiovasc Care 2019 Feb;8(1):5-7

University of Texas Southwestern Medical Center, Internal Medicine, NB11.200, UT Southwestern, Dallas, TX, USA.

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http://dx.doi.org/10.1177/2048872619830352DOI Listing
February 2019
2 Reads

Focus on ST elevation myocardial infarction.

Authors:

Eur Heart J Acute Cardiovasc Care 2019 Feb;8(1):3-4

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http://dx.doi.org/10.1177/2048872619831565DOI Listing
February 2019
3 Reads

Beta-blockers for post-acute coronary syndrome mid-range ejection fraction: a nationwide retrospective study.

Eur Heart J Acute Cardiovasc Care 2019 Feb 4:2048872619827476. Epub 2019 Feb 4.

2 Portuguese Society of Cardiology, Portugal.

Background:: Patients with mid-range ejection fraction (40-49%) are in focus due to the newly defined entity of heart failure with mid-range ejection fraction. Acute coronary syndromes are a major aetiology for heart failure with mid-range ejection fraction. We aim to evaluate which therapeutic decisions are associated with inhospital survival benefit in post-acute coronary syndrome patients categorised according to the ejection fraction. Read More

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http://dx.doi.org/10.1177/2048872619827476DOI Listing
February 2019
4 Reads

Acute diagonal-induced ST-elevation myocardial infarction and electrocardiogram-guidance in the era of primary coronary intervention: New insights into an old tool.

Eur Heart J Acute Cardiovasc Care 2019 Feb 1:2048872619828291. Epub 2019 Feb 1.

Heart Institute, Hillel Yaffe Medical Center Affiliated with Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

Background:: Previous studies, published before the advent of primary reperfusion, described the electrocardiographic features of ST-segment elevation myocardial infarction (STEMI) caused by total diagonal artery occlusion, as demonstrated at pre-discharge coronary angiography. We aimed to assess the electrocardiographic and echocardiographic features in STEMI unequivocally attributed to a diagonal lesion in the era of primary coronary intervention.

Methods:: The electrocardiograms and echocardiograms of patients sustaining STEMI caused by diagonal artery involvement were compared with those of patients with STEMI attributed to proximal or mid left anterior descending artery (LAD) lesions. Read More

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http://dx.doi.org/10.1177/2048872619828291DOI Listing
February 2019
3 Reads

Hyponatremia at discharge is associated with adverse prognosis in acute heart failure syndromes with preserved ejection fraction: a report from the JASPER registry.

Eur Heart J Acute Cardiovasc Care 2019 Jan 22:2048872618822459. Epub 2019 Jan 22.

2 Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Japan.

Introduction:: Hyponatremia predicts adverse prognosis in patients with heart failure in particular with reduced ejection fraction. In contrast, it has recently been reported that hyponatremia on admission is not a predictor of post-discharge mortality in patients with heart failure with preserved ejection fraction. We investigated the prognostic impact of hyponatremia at discharge in patients with heart failure with preserved ejection fraction and its clinical characteristics. Read More

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http://dx.doi.org/10.1177/2048872618822459DOI Listing
January 2019
9 Reads

Temporal trends in management and outcomes of patients with acute coronary syndrome according to body mass index.

Eur Heart J Acute Cardiovasc Care 2019 Jan 21:2048872619825569. Epub 2019 Jan 21.

3 Heart Institute, Hadassah Hebrew University Medical Center, Israel.

Background:: Obesity is a major public health concern. We sought to investigate temporal trends in characteristics and outcomes of acute coronary syndrome patients according to body mass index.

Methods:: The study population consisted of patients who were included in the Acute Coronary Syndromes Israeli Surveys during 2000-2016. Read More

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http://journals.sagepub.com/doi/10.1177/2048872619825569
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http://dx.doi.org/10.1177/2048872619825569DOI Listing
January 2019
10 Reads

The prognostic impact of the uric acid level in patients who require cardiovascular intensive care - is serum uric acid a surrogate biomarker for critical patients in the non-surgical intensive care unit?

Eur Heart J Acute Cardiovasc Care 2019 Jan 17:2048872618822473. Epub 2019 Jan 17.

4 Department of Cardiovascular Medicine, Nippon Medical School Hospital, Tokyo, Japan.

Background:: The prognostic impact of hyperuricemia and the factors that induce hyperuricemia in cardiovascular intensive care patients remain unclear.

Methods And Results:: A total of 3257 emergency department patients were screened, and data for 2435 patients who were admitted to an intensive care unit were analyzed. The serum uric acid level was measured within 15 min of admission. Read More

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http://dx.doi.org/10.1177/2048872618822473DOI Listing
January 2019
6 Reads

Survival of patients with and without diabetes following out-of-hospital cardiac arrest: A nationwide Danish study.

Eur Heart J Acute Cardiovasc Care 2019 Jan 11:2048872618823349. Epub 2019 Jan 11.

1 Department of Cardiology, Herlev and Gentofte Hospital, University of Copenhagen, Gentofte, Denmark.

Background:: Research regarding out-of-hospital cardiac arrest (OHCA) survival of diabetes patients is sparse and it remains unknown whether initiatives to increase OHCA survival benefit diabetes and non-diabetes patients equally. We therefore examined overall and temporal survival in diabetes and non-diabetes patients following OHCA.

Methods:: Adult presumed cardiac-caused OHCAs were identified from the Danish Cardiac Arrest Registry (2001-2014). Read More

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http://dx.doi.org/10.1177/2048872618823349DOI Listing
January 2019
11 Reads

Electrocardiography changes and their significance during treatment of patients with intermediate-high and high-risk pulmonary embolism.

Eur Heart J Acute Cardiovasc Care 2019 Jan 11:2048872618823441. Epub 2019 Jan 11.

1 Clinic of Cardiology and Urgent Internal Medicine, Military Medical Academy, Serbia.

Background:: Electrocardiography (ECG) signs, typical or acute pulmonary embolism, and their changes can be used for the prediction of clinical and haemodynamic outcomes.

Purpose:: To study the predictive value of the resolution of admission ECG signs in higher risk pulmonary embolism patients for 30-day survival and for the decrease in right ventricular systolic pressure.

Methods:: We analysed the 12-lead ECGs at admission and daily for the first 5 days after hospitalisation in 110 intermediate-high and high-risk pulmonary embolism patients admitted to the intensive care unit of a single tertiary centre. Read More

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http://dx.doi.org/10.1177/2048872618823441DOI Listing
January 2019
5 Reads

Release of mitochondrial DNA is associated with mortality in severe acute heart failure.

Eur Heart J Acute Cardiovasc Care 2019 Jan 11:2048872618823405. Epub 2019 Jan 11.

1 Department of Internal Medicine II, Medical University of Vienna, Austria.

Background:: Inflammation is regarded as an important trigger for disease progression in heart failure. Particularly in severe acute heart failure, tissue hypoxia may lead to cellular damage and the release of intracellular mitochondrial DNA, which acts as an activator of the immune system due to its resemblance to bacterial DNA. It may therefore serve as a mediator of disease progression. Read More

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http://dx.doi.org/10.1177/2048872618823405DOI Listing
January 2019
13 Reads

Serial high-sensitivity cardiac troponin T measurements to rule out acute myocardial infarction and a single high baseline measurement for swift rule-in: A systematic review and meta-analysis.

Eur Heart J Acute Cardiovasc Care 2019 Jan 8:2048872618819421. Epub 2019 Jan 8.

1 Department of Cardiology, Erasmus Medical Centre, The Netherlands.

Aims:: The purpose of this study was to determine (a) the ability of serial high-sensitivity cardiac troponin T measurements to rule out acute myocardial infarction and (b) the ability of a single high baseline high-sensitivity cardiac troponin T measurement to rule in acute myocardial infarction in patients presenting to the emergency department with acute chest pain.

Methods And Results:: Embase, Medline, Cochrane, Web of Science and Google scholar were searched for prospective cohort studies that evaluated parameters of diagnostic accuracy of serial high-sensitivity cardiac troponin T to rule out acute myocardial infarction and a single baseline high-sensitivity cardiac troponin T value>50 ng/l to rule in acute myocardial infarction. The search yielded 21 studies for the systematic review, of which 14 were included in the meta-analysis, with a total of 11,929 patients and an overall prevalence of acute myocardial infarction of 13. Read More

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http://dx.doi.org/10.1177/2048872618819421DOI Listing
January 2019
3 Reads

Incidence and outcome of peri-procedural cardiogenic shock: results from the international Euro Heart Survey PCI registry.

Eur Heart J Acute Cardiovasc Care 2019 Jan 8:2048872618822460. Epub 2019 Jan 8.

1 Department of Cardiology, Justus-Liebig University of Giessen, Germany.

Background:: There is a large body of literature on acute myocardial infarction complicated by cardiogenic shock. However, very little is known about patients who are initially haemodynamically stable and develop cardiogenic shock during percutaneous coronary intervention.

Methods:: A total of 47,407 consecutive patients were prospectively enrolled in the PCI Registry of the Euro Heart Survey Programme. Read More

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http://journals.sagepub.com/doi/10.1177/2048872618822460
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http://dx.doi.org/10.1177/2048872618822460DOI Listing
January 2019
14 Reads

Targeting elevated left ventricular end-diastolic pressure following primary percutaneous coronary intervention for ST-segment elevation myocardial infarction - a phase one safety and feasibility study.

Eur Heart J Acute Cardiovasc Care 2018 Dec 20:2048872618819657. Epub 2018 Dec 20.

1 John Hunter Hospital, Newcastle, Australia.

Introduction:: Elevated left ventricular end diastolic pressure (LVEDP) is an independent predictor of mortality and heart failure in patients with ST-segment elevation myocardial infarction (STEMI). Whether lowering elevated LVEDP improves outcomes remains unknown.

Methods:: This non-randomized, single blinded study with prospective enrolment and sequential group allocation recruited patients undergoing primary percutaneous coronary intervention for STEMI with LVEDP ⩾ 20 mmHg measured immediately after primary percutaneous coronary intervention. Read More

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http://dx.doi.org/10.1177/2048872618819657DOI Listing
December 2018
5 Reads

Time is up for treatment inequity in women with acute coronary syndromes.

Eur Heart J Acute Cardiovasc Care 2019 Apr 13;8(3):291-292. Epub 2018 Dec 13.

Department of Cardiology, Radboud University Medical Center, The Netherlands.

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http://dx.doi.org/10.1177/2048872618820190DOI Listing
April 2019
3 Reads

The role of perioperative cardiorespiratory support in post infarction ventricular septal rupture-related cardiogenic shock.

Eur Heart J Acute Cardiovasc Care 2018 Dec 10:2048872618817485. Epub 2018 Dec 10.

1 Intensive Cardiac Care Unit, Cardiology Department, Heart Disease Institute, Bellvitge University Hospital, Barcelona, Spain.

Background:: Current guidelines recommend emergency surgical correction in patients with post infarction ventricular septal rupture (PIVSR), but patients with multiorgan failure are commonly managed conservatively because of high surgical risk. We assessed characteristics and outcomes of operated PIVSR patients with or without the use of short-term ventricular assist devices (ST-VADs). We also assessed the impact of a ST-VAD on the performance of surgery. Read More

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http://dx.doi.org/10.1177/2048872618817485DOI Listing
December 2018
9 Reads

Multisite vascular disease in acute coronary syndromes: increased in-hospital mortality and no improvement over time.

Eur Heart J Acute Cardiovasc Care 2018 Dec 5:2048872618814708. Epub 2018 Dec 5.

7 Division of Cardiology, St. Gallen County Hospital, St. Gallen, Switzerland.

Introduction:: Limited data are available on the impact of multisite artery disease in patients with acute coronary syndromes. In particular, it is unknown whether the outcomes of those high-risk patients have improved over time. Therefore, we addressed the multisite artery disease patient population enrolled in the Swiss nationwide prospective acute coronary syndromes cohort study AMIS Plus over two decades. Read More

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http://dx.doi.org/10.1177/2048872618814708DOI Listing
December 2018
4 Reads

Renal dysfunction and cardiogenic shock complicating acute coronary syndromes.

Authors:

Eur Heart J Acute Cardiovasc Care 2018 Dec;7(8):687-688

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http://journals.sagepub.com/doi/10.1177/2048872618819089
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http://dx.doi.org/10.1177/2048872618819089DOI Listing
December 2018
18 Reads

Prognostic significance of emergency department bypass in stable and unstable patients with ST-segment elevation myocardial infarction.

Eur Heart J Acute Cardiovasc Care 2018 Nov 27:2048872618813907. Epub 2018 Nov 27.

7 Comprehensive Heart Failure Center Würzburg, Germany.

Background:: In ST-segment elevation myocardial infarction (STEMI) patients treated with percutaneous coronary intervention, direct transport from the scene to the catheterisation laboratory bypassing the emergency department has been shown to shorten times to reperfusion. The aim of this study was to investigate the effects of emergency department bypass on mortality in both haemodynamically stable and unstable STEMI patients.

Methods:: The analysis is based on a large cohort of STEMI patients prospectively included in the German multicentre Feedback Intervention and Treatment Times in ST-Elevation Myocardial Infarction (FITT-STEMI) trial. Read More

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http://dx.doi.org/10.1177/2048872618813907DOI Listing
November 2018
6 Reads

Pre-hospital risk assessment in suspected non-ST-elevation acute coronary syndrome: A prospective observational study.

Eur Heart J Acute Cardiovasc Care 2018 Nov 23:2048872618813846. Epub 2018 Nov 23.

1 Department of Cardiology, Isala Hospital, Zwolle, The Netherlands.

Background:: Pre-hospital risk stratification of non-ST-elevation acute coronary syndrome (NSTE-ACS) by the complete HEART score has not yet been assessed. We investigated whether pre-hospital risk stratification of patients with suspected NSTE-ACS using the HEART score is accurate in predicting major adverse cardiac events (MACE).

Methods:: This is a prospective observational study, including 700 patients with suspected NSTE-ACS. Read More

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http://dx.doi.org/10.1177/2048872618813846DOI Listing
November 2018
4 Reads

Long term survival after early unloading with Impella CP in acute myocardial infarction complicated by cardiogenic shock.

Eur Heart J Acute Cardiovasc Care 2018 Nov 20:2048872618815063. Epub 2018 Nov 20.

1 Department for Internal Medicine and Cardiology, Herzzentrum Dresden University Clinic, Technische Universität Dresden, Germany.

Background:: The use of percutaneous left ventricular assist devices in patients with acute myocardial infarction complicated by cardiogenic shock (AMICS) is evolving. The aim of the study was to assess the long-term outcome of patients with AMICS depending on early initiation of Impella CP support prior to a percutaneous coronary intervention (PCI).

Methods:: We retrospectively reviewed all patients who underwent PCI and Impella CP support between 2014 and 2016 for AMICS at our institution. Read More

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http://journals.sagepub.com/doi/10.1177/2048872618815063
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http://dx.doi.org/10.1177/2048872618815063DOI Listing
November 2018
34 Reads

Serum neprilysin and the risk of death in patients with out-of-hospital cardiac arrest of non-traumatic origin.

Eur Heart J Acute Cardiovasc Care 2018 Nov 19:2048872618815062. Epub 2018 Nov 19.

Department of Cardiology, Angiology, and Pneumology, University Hospital Heidelberg, Germany.

Background:: Early risk stratification remains an unmet clinical need in patients with in out-of-hospital cardiac arrest. We hypothesised that soluble neprilysin may represent a promising biomarker in patients with out-of-hospital cardiac arrest of non-traumatic origin and provide new pathobiological insight.

Methods:: This pilot study was a biomarker analysis from the Heidelberg Resuscitation Registry. Read More

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http://dx.doi.org/10.1177/2048872618815062DOI Listing
November 2018
17 Reads

Intramural haematoma of the ascending aorta - not so malignant after all?

Authors:
Udo Sechtem

Eur Heart J Acute Cardiovasc Care 2018 Nov 14:2048872618812397. Epub 2018 Nov 14.

Associate Professor, University of Tübingen, Germany.

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http://dx.doi.org/10.1177/2048872618812397DOI Listing
November 2018
10 Reads

Editor's Choice- Reperfusion cardiac arrhythmias and their relation to reperfusion-induced cell death.

Eur Heart J Acute Cardiovasc Care 2019 Mar 13;8(2):142-152. Epub 2018 Nov 13.

1 Department of Cardiology, Maastricht University Medical Center, The Netherlands.

Reperfusion does not only salvage ischaemic myocardium but can also cause additional cell death which is called lethal reperfusion injury. The time of reperfusion is often accompanied by ventricular arrhythmias, i.e. Read More

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http://journals.sagepub.com/doi/10.1177/2048872618812148
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http://dx.doi.org/10.1177/2048872618812148DOI Listing
March 2019
15 Reads

Outcomes of medically managed patients with myocardial infarction.

Eur Heart J Acute Cardiovasc Care 2018 Nov 13:2048872618812135. Epub 2018 Nov 13.

1 Department of Medicine, University of Alberta, Canada.

Aims:: The purpose of this study was to compare outcomes associated with medical management of ST-elevation myocardial infarction and non-ST-elevation myocardial infarction patients presenting to hospitals with and without onsite catheterization facilities.

Methods: All patients ( n=25,921) with ST-elevation myocardial infarction ( n=10,563) or non-ST-elevation myocardial infarction ( n=15,358) in Alberta, Canada between April 2010-March 2016 were categorized according to availability of catheterization facilities at the hospital they presented to and their management strategy (medically managed without coronary angiography or medically managed after coronary angiography).

Results:: Overall, 51% presented to hospitals without catheterization facilities; and 34% were managed medically (18% without coronary angiography, and 16% after coronary angiography). Read More

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http://journals.sagepub.com/doi/10.1177/2048872618812135
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http://dx.doi.org/10.1177/2048872618812135DOI Listing
November 2018
13 Reads

Cardiac involvement in critically ill patients with leptospirosis: A prospective study using myocardial deformation imaging.

Eur Heart J Acute Cardiovasc Care 2018 Nov 8:2048872618809319. Epub 2018 Nov 8.

2 Division of Cardiology, University of Alberta, Canada.

Background:: Myocardial inflammation often complicates leptospirosis, a re-emerging global zoonosis. Leptospirosis associated myocardial dysfunction is equivocal and the pattern of cardiac involvement may not differ from that of sepsis associated myocarditis.

Methods:: We prospectively compared cardiac involvement in 113 intensive care unit patients with severe leptospirosis to 31 patients with sepsis syndrome using a comprehensive assessment comprising of clinical presentation, electrocardiography, two-dimensional echocardiography (with global longitudinal strain calculation), and cardiac biomarker evaluation. Read More

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http://dx.doi.org/10.1177/2048872618809319DOI Listing
November 2018
18 Reads

Survival after refractory cardiogenic shock is comparable in patients with Impella and veno-arterial extracorporeal membrane oxygenation when adjusted for SAVE score.

Eur Heart J Acute Cardiovasc Care 2018 Nov 8:2048872618799745. Epub 2018 Nov 8.

Department of Cardiothoracic Surgery, University Hospital Uppsala, Sweden.

Objectives:: Survival after different short-term mechanical circulatory support is difficult to compare because various systems are used and patient disease severity is most often not adjusted for. This study compares the outcome after the use of Impella and veno-arterial extracorporeal membrane oxygenation (VA-ECMO) in refractory cardiogenic shock, adjusted for disease severity through the survival after the VA-ECMO (SAVE) score.

Methods:: Patients with refractory shock treated with either VA-ECMO or Impella between January 2003 and August 2015 were included. Read More

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http://journals.sagepub.com/doi/10.1177/2048872618799745
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http://dx.doi.org/10.1177/2048872618799745DOI Listing
November 2018
18 Reads

Gender differences in patient and system delay for primary percutaneous coronary intervention: current trends in a Swiss ST-segment elevation myocardial infarction population.

Eur Heart J Acute Cardiovasc Care 2019 Apr 8;8(3):283-290. Epub 2018 Nov 8.

1 Division of Cardiology, Triemli Hospital, Zurich, Switzerland.

Background: Women with ST-segment elevation myocardial infarction (STEMI) experience greater delays for percutaneous coronary intervention-facilitated reperfusion than men. Whether women and men benefit equally from current strategies to reduce ischaemic time and whether there are gender differences in factors determining delays is unclear.

Methods: Patient delay (symptom onset to first medical contact) and system delay (first medical contact to percutaneous coronary intervention-facilitated reperfusion) were compared between women ( n=967) and men ( n=3393) in a Swiss STEMI treatment network. Read More

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http://dx.doi.org/10.1177/2048872618810410DOI Listing
April 2019
16 Reads

Real-life use of left ventricular circulatory support with Impella in cardiogenic shock after acute myocardial infarction: 12 years AMC experience.

Eur Heart J Acute Cardiovasc Care 2018 Nov 7:2048872618805486. Epub 2018 Nov 7.

1 Heart Center; department of Cardiology, Amsterdam UMC, The Netherlands.

Aims:: Mortality in cardiogenic shock patients remains high. Short-term mechanical circulatory support with Impella can be used to support the circulation in these patients, but data from randomised controlled studies and 'real-world' data are sparse. The aim is to describe real-life data on outcomes and complications of our 12 years of clinical experience with Impella in patients with cardiogenic shock after acute myocardial infarction and to identify predictors of 6-month mortality. Read More

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http://dx.doi.org/10.1177/2048872618805486DOI Listing
November 2018
27 Reads

Atrial fibrillation detected initially during acute medical illness: A systematic review.

Eur Heart J Acute Cardiovasc Care 2019 Mar 7;8(2):130-141. Epub 2018 Nov 7.

1 Population Health Research Institute, McMaster University, Canada.

Objective:: There is uncertainty about the incidence of and prognosis associated with atrial fibrillation that is documented for the first time in the setting of an acute stressor, such as surgery or medical illness. Our objective was to perform a systematic review of the incidence and long-term recurrence rates for atrial fibrillation occurring transiently with stress in the setting of acute medical illness.

Data Sources:: Medline, Embase and Cochrane Central to September 2017. Read More

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http://journals.sagepub.com/doi/10.1177/2048872618799748
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http://dx.doi.org/10.1177/2048872618799748DOI Listing
March 2019
36 Reads

Smoking is the dominating modifiable risk factor in younger patients with STEMI.

Eur Heart J Acute Cardiovasc Care 2018 Nov 2:2048872618810414. Epub 2018 Nov 2.

1 Department of Cardiology, Aarhus University Hospital, Denmark.

Aims:: Smoking is an important modifiable risk factor for myocardial infarction. It is unclear whether smoking habits at the time of an incident ST-segment elevation myocardial infarction (STEMI) differ across age groups and sex.

Methods And Results:: We included patients with incident STEMI registered in the Western Denmark Heart Registry from 2005 to 2015 ( n=9914). Read More

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http://dx.doi.org/10.1177/2048872618810414DOI Listing
November 2018
10 Reads

Right bundle branch block in patients with suspected myocardial infarction.

Eur Heart J Acute Cardiovasc Care 2019 Mar 26;8(2):161-166. Epub 2018 Oct 26.

1 University Heart Center Hamburg, Germany.

Aims:: The new European Society of Cardiology guideline for ST-segment elevation myocardial infarction recommends that left and right bundle branch block should be considered equal for recommending urgent angiography in patients with suspected myocardial infarction. We aimed to evaluate this novel recommendation in two prospective studies of patients with suspected myocardial infarction.

Methods And Results:: We included 4067 patients presenting to the emergency department with suspected myocardial infarction. Read More

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http://dx.doi.org/10.1177/2048872618809700DOI Listing
March 2019
4 Reads

Atrial fibrillation occurring initially during acute medical illness: the heterogeneous nature of disease, outcomes and management strategies.

Eur Heart J Acute Cardiovasc Care 2018 Oct 24:2048872618801763. Epub 2018 Oct 24.

1 Institute of Cardiovascular Sciences, University of Birmingham, UK.

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http://dx.doi.org/10.1177/2048872618801763DOI Listing
October 2018
14 Reads

Sex-related response to bivalirudin and unfractionated heparin in patients with acute myocardial infarction undergoing percutaneous coronary intervention: A subgroup analysis of the VALIDATE-SWEDEHEART trial.

Eur Heart J Acute Cardiovasc Care 2018 Oct 23:2048872618803760. Epub 2018 Oct 23.

1 Department of Cardiology and Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.

Aims:: Our aim was to study the impact of sex on anticoagulant treatment outcomes during percutaneous coronary intervention in acute myocardial infarction patients.

Methods:: This study was a prespecified analysis of the Bivalirudin versus Heparin in ST-Segment and Non ST-Segment Elevation Myocardial Infarction in Patients on Modern Antiplatelet Therapy in the Swedish Web System for Enhancement and Development of Evidence-based Care in Heart Disease Evaluated according to Recommended Therapies Registry Trial (VALIDATE-SWEDEHEART) trial, in which patients with myocardial infarction were randomised to bivalirudin or unfractionated heparin during percutaneous coronary intervention. The primary outcome was the composite of death, myocardial infarction or major bleeding at 180 days. Read More

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http://dx.doi.org/10.1177/2048872618803760DOI Listing
October 2018
18 Reads

Outcomes of early and reversible renal impairment in patients with ST segment elevation myocardial infarction undergoing percutaneous coronary intervention.

Eur Heart J Acute Cardiovasc Care 2018 Oct 17:2048872618808456. Epub 2018 Oct 17.

Department of Cardiology, Tel-Aviv Sourasky Medical Center affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Israel.

Objective: Acute kidney injury (AKI) is a frequent complication in patients with ST segment elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI). While AKI occurring post-PCI has been well studied, the incidence and clinical significance of early renal impairment evident on hospital admission prior to PCI and which resolves towards discharge has not been investigated.

Methods: We retrospectively studied 2339 STEMI patients treated with primary PCI. Read More

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http://dx.doi.org/10.1177/2048872618808456DOI Listing
October 2018
4 Reads

Triage, diagnosis and management of acute chest pain syndromes, atypical and high-risk subtypes of acute coronary artery syndromes.

Eur Heart J Acute Cardiovasc Care 2018 Oct;7(7):589-590

Cardiovascular diseases, University of Antwerp, Belgium.

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http://dx.doi.org/10.1177/2048872618810252DOI Listing
October 2018
2 Reads

The efficacy and safety of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation and coronary artery disease: A meta-analysis of randomized trials.

Eur Heart J Acute Cardiovasc Care 2018 Oct 15:2048872618796990. Epub 2018 Oct 15.

TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA.

Background: Patients with atrial fibrillation and concomitant coronary artery disease (CAD) are at higher risk for myocardial infarction or cardiovascular death, often require antiplatelet therapy and are therefore exposed to an increased risk of bleeding. This meta-analysis aimed to compare the efficacy and safety profile of non-vitamin K antagonist oral anticoagulants (NOACs) with warfarin in patients with atrial fibrillation and concomitant CAD.

Materials And Methods: We performed a trial-level meta-analysis of CAD subgroups from four trials of NOAC versus warfarin in patients with atrial fibrillation, comparing the primary trial endpoints (efficacy: stroke or systemic embolic event; safety: International Society on Thrombosis and Haemostasis major bleeding) in patients with versus those without CAD, and used interaction testing to assess for treatment effect modification. Read More

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http://dx.doi.org/10.1177/2048872618796990DOI Listing
October 2018
12 Reads

Bivalirudin versus heparin monotherapy in non-ST-segment elevation myocardial infarction.

Eur Heart J Acute Cardiovasc Care 2018 Oct 3:2048872618805663. Epub 2018 Oct 3.

14 Department of Medical Sciences, Uppsala University, Sweden.

Background: The optimal anti-coagulation strategy for patients with non-ST-elevation myocardial infarction treated with percutaneous coronary intervention is unclear in contemporary clinical practice of radial access and potent P2Y12-inhibitors. The aim of this study was to investigate whether bivalirudin was superior to heparin monotherapy in patients with non-ST-elevation myocardial infarction without routine glycoprotein IIb/IIIa inhibitor use.

Methods: In a large pre-specified subgroup of the multicentre, prospective, randomised, registry-based, open-label clinical VALIDATE-SWEDEHEART trial we randomised patients with non-ST-elevation myocardial infarction undergoing percutaneous coronary intervention, treated with ticagrelor or prasugrel, to bivalirudin or heparin monotherapy with no planned use of glycoprotein IIb/IIIa inhibitors during percutaneous coronary intervention. Read More

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http://journals.sagepub.com/doi/10.1177/2048872618805663
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http://dx.doi.org/10.1177/2048872618805663DOI Listing
October 2018
8 Reads