619 results match your criteria European Heart Journal: Acute Cardiovascular Care [Journal]


Early intravenous beta-blockers in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: A patient-pooled meta-analysis of randomized clinical trials.

Eur Heart J Acute Cardiovasc Care 2019 Feb 14:2048872619830609. Epub 2019 Feb 14.

3 Department of Cardiology, Radboud University Medical Center, The Netherlands.

Background:: Conflicting evidence is available on the efficacy and safety of early intravenous beta-blockers before primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. We performed a patient-pooled meta-analysis of trials comparing early intravenous beta-blockers with placebo or routine care in ST-segment elevation myocardial infarction patients undergoing primary percutaneous coronary intervention.

Aim:: The aim of this study was to evaluate the clinical and safety outcomes of intravenous beta-blockers in ST-segment elevation myocardial infarction patients undergoing primary percutaneous coronary intervention. Read More

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http://dx.doi.org/10.1177/2048872619830609DOI Listing
February 2019

Medical Misinformation: Vet the Message!

Authors:
Joseph A Hill

Eur Heart J Acute Cardiovasc Care 2019 Feb;8(1):5-7

University of Texas Southwestern Medical Center, Internal Medicine, NB11.200, UT Southwestern, Dallas, TX, USA.

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http://dx.doi.org/10.1177/2048872619830352DOI Listing
February 2019
2 Reads

Focus on ST elevation myocardial infarction.

Authors:

Eur Heart J Acute Cardiovasc Care 2019 Feb;8(1):3-4

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http://dx.doi.org/10.1177/2048872619831565DOI Listing
February 2019
2 Reads

Beta-blockers for post-acute coronary syndrome mid-range ejection fraction: a nationwide retrospective study.

Eur Heart J Acute Cardiovasc Care 2019 Feb 4:2048872619827476. Epub 2019 Feb 4.

2 Portuguese Society of Cardiology, Portugal.

Background:: Patients with mid-range ejection fraction (40-49%) are in focus due to the newly defined entity of heart failure with mid-range ejection fraction. Acute coronary syndromes are a major aetiology for heart failure with mid-range ejection fraction. We aim to evaluate which therapeutic decisions are associated with inhospital survival benefit in post-acute coronary syndrome patients categorised according to the ejection fraction. Read More

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http://dx.doi.org/10.1177/2048872619827476DOI Listing
February 2019
1 Read

Acute diagonal-induced ST-elevation myocardial infarction and electrocardiogram-guidance in the era of primary coronary intervention: New insights into an old tool.

Eur Heart J Acute Cardiovasc Care 2019 Feb 1:2048872619828291. Epub 2019 Feb 1.

Heart Institute, Hillel Yaffe Medical Center Affiliated with Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

Background:: Previous studies, published before the advent of primary reperfusion, described the electrocardiographic features of ST-segment elevation myocardial infarction (STEMI) caused by total diagonal artery occlusion, as demonstrated at pre-discharge coronary angiography. We aimed to assess the electrocardiographic and echocardiographic features in STEMI unequivocally attributed to a diagonal lesion in the era of primary coronary intervention.

Methods:: The electrocardiograms and echocardiograms of patients sustaining STEMI caused by diagonal artery involvement were compared with those of patients with STEMI attributed to proximal or mid left anterior descending artery (LAD) lesions. Read More

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http://dx.doi.org/10.1177/2048872619828291DOI Listing
February 2019

Hyponatremia at discharge is associated with adverse prognosis in acute heart failure syndromes with preserved ejection fraction: a report from the JASPER registry.

Eur Heart J Acute Cardiovasc Care 2019 Jan 22:2048872618822459. Epub 2019 Jan 22.

2 Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Japan.

Introduction:: Hyponatremia predicts adverse prognosis in patients with heart failure in particular with reduced ejection fraction. In contrast, it has recently been reported that hyponatremia on admission is not a predictor of post-discharge mortality in patients with heart failure with preserved ejection fraction. We investigated the prognostic impact of hyponatremia at discharge in patients with heart failure with preserved ejection fraction and its clinical characteristics. Read More

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http://dx.doi.org/10.1177/2048872618822459DOI Listing
January 2019
3 Reads

Temporal trends in management and outcomes of patients with acute coronary syndrome according to body mass index.

Eur Heart J Acute Cardiovasc Care 2019 Jan 21:2048872619825569. Epub 2019 Jan 21.

3 Heart Institute, Hadassah Hebrew University Medical Center, Israel.

Background:: Obesity is a major public health concern. We sought to investigate temporal trends in characteristics and outcomes of acute coronary syndrome patients according to body mass index.

Methods:: The study population consisted of patients who were included in the Acute Coronary Syndromes Israeli Surveys during 2000-2016. Read More

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http://journals.sagepub.com/doi/10.1177/2048872619825569
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http://dx.doi.org/10.1177/2048872619825569DOI Listing
January 2019
6 Reads

The prognostic impact of the uric acid level in patients who require cardiovascular intensive care - is serum uric acid a surrogate biomarker for critical patients in the non-surgical intensive care unit?

Eur Heart J Acute Cardiovasc Care 2019 Jan 17:2048872618822473. Epub 2019 Jan 17.

4 Department of Cardiovascular Medicine, Nippon Medical School Hospital, Tokyo, Japan.

Background:: The prognostic impact of hyperuricemia and the factors that induce hyperuricemia in cardiovascular intensive care patients remain unclear.

Methods And Results:: A total of 3257 emergency department patients were screened, and data for 2435 patients who were admitted to an intensive care unit were analyzed. The serum uric acid level was measured within 15 min of admission. Read More

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http://dx.doi.org/10.1177/2048872618822473DOI Listing
January 2019
3 Reads

Survival of patients with and without diabetes following out-of-hospital cardiac arrest: A nationwide Danish study.

Eur Heart J Acute Cardiovasc Care 2019 Jan 11:2048872618823349. Epub 2019 Jan 11.

1 Department of Cardiology, Herlev and Gentofte Hospital, University of Copenhagen, Gentofte, Denmark.

Background:: Research regarding out-of-hospital cardiac arrest (OHCA) survival of diabetes patients is sparse and it remains unknown whether initiatives to increase OHCA survival benefit diabetes and non-diabetes patients equally. We therefore examined overall and temporal survival in diabetes and non-diabetes patients following OHCA.

Methods:: Adult presumed cardiac-caused OHCAs were identified from the Danish Cardiac Arrest Registry (2001-2014). Read More

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http://dx.doi.org/10.1177/2048872618823349DOI Listing
January 2019
7 Reads

Electrocardiography changes and their significance during treatment of patients with intermediate-high and high-risk pulmonary embolism.

Eur Heart J Acute Cardiovasc Care 2019 Jan 11:2048872618823441. Epub 2019 Jan 11.

1 Clinic of Cardiology and Urgent Internal Medicine, Military Medical Academy, Serbia.

Background:: Electrocardiography (ECG) signs, typical or acute pulmonary embolism, and their changes can be used for the prediction of clinical and haemodynamic outcomes.

Purpose:: To study the predictive value of the resolution of admission ECG signs in higher risk pulmonary embolism patients for 30-day survival and for the decrease in right ventricular systolic pressure.

Methods:: We analysed the 12-lead ECGs at admission and daily for the first 5 days after hospitalisation in 110 intermediate-high and high-risk pulmonary embolism patients admitted to the intensive care unit of a single tertiary centre. Read More

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http://dx.doi.org/10.1177/2048872618823441DOI Listing
January 2019
3 Reads

Release of mitochondrial DNA is associated with mortality in severe acute heart failure.

Eur Heart J Acute Cardiovasc Care 2019 Jan 11:2048872618823405. Epub 2019 Jan 11.

1 Department of Internal Medicine II, Medical University of Vienna, Austria.

Background:: Inflammation is regarded as an important trigger for disease progression in heart failure. Particularly in severe acute heart failure, tissue hypoxia may lead to cellular damage and the release of intracellular mitochondrial DNA, which acts as an activator of the immune system due to its resemblance to bacterial DNA. It may therefore serve as a mediator of disease progression. Read More

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http://dx.doi.org/10.1177/2048872618823405DOI Listing
January 2019
9 Reads

Serial high-sensitivity cardiac troponin T measurements to rule out acute myocardial infarction and a single high baseline measurement for swift rule-in: A systematic review and meta-analysis.

Eur Heart J Acute Cardiovasc Care 2019 Jan 8:2048872618819421. Epub 2019 Jan 8.

1 Department of Cardiology, Erasmus Medical Centre, The Netherlands.

Aims:: The purpose of this study was to determine (a) the ability of serial high-sensitivity cardiac troponin T measurements to rule out acute myocardial infarction and (b) the ability of a single high baseline high-sensitivity cardiac troponin T measurement to rule in acute myocardial infarction in patients presenting to the emergency department with acute chest pain.

Methods And Results:: Embase, Medline, Cochrane, Web of Science and Google scholar were searched for prospective cohort studies that evaluated parameters of diagnostic accuracy of serial high-sensitivity cardiac troponin T to rule out acute myocardial infarction and a single baseline high-sensitivity cardiac troponin T value>50 ng/l to rule in acute myocardial infarction. The search yielded 21 studies for the systematic review, of which 14 were included in the meta-analysis, with a total of 11,929 patients and an overall prevalence of acute myocardial infarction of 13. Read More

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http://dx.doi.org/10.1177/2048872618819421DOI Listing
January 2019
2 Reads

Incidence and outcome of peri-procedural cardiogenic shock: results from the international Euro Heart Survey PCI registry.

Eur Heart J Acute Cardiovasc Care 2019 Jan 8:2048872618822460. Epub 2019 Jan 8.

1 Department of Cardiology, Justus-Liebig University of Giessen, Germany.

Background:: There is a large body of literature on acute myocardial infarction complicated by cardiogenic shock. However, very little is known about patients who are initially haemodynamically stable and develop cardiogenic shock during percutaneous coronary intervention.

Methods:: A total of 47,407 consecutive patients were prospectively enrolled in the PCI Registry of the Euro Heart Survey Programme. Read More

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http://journals.sagepub.com/doi/10.1177/2048872618822460
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http://dx.doi.org/10.1177/2048872618822460DOI Listing
January 2019
8 Reads

Targeting elevated left ventricular end-diastolic pressure following primary percutaneous coronary intervention for ST-segment elevation myocardial infarction - a phase one safety and feasibility study.

Eur Heart J Acute Cardiovasc Care 2018 Dec 20:2048872618819657. Epub 2018 Dec 20.

1 John Hunter Hospital, Newcastle, Australia.

Introduction:: Elevated left ventricular end diastolic pressure (LVEDP) is an independent predictor of mortality and heart failure in patients with ST-segment elevation myocardial infarction (STEMI). Whether lowering elevated LVEDP improves outcomes remains unknown.

Methods:: This non-randomized, single blinded study with prospective enrolment and sequential group allocation recruited patients undergoing primary percutaneous coronary intervention for STEMI with LVEDP ⩾ 20 mmHg measured immediately after primary percutaneous coronary intervention. Read More

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http://dx.doi.org/10.1177/2048872618819657DOI Listing
December 2018
4 Reads

Time is up for treatment inequity in women with acute coronary syndromes.

Eur Heart J Acute Cardiovasc Care 2018 Dec 13:2048872618820190. Epub 2018 Dec 13.

Department of Cardiology, Radboud University Medical Center, The Netherlands.

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http://dx.doi.org/10.1177/2048872618820190DOI Listing
December 2018
3 Reads

The role of perioperative cardiorespiratory support in post infarction ventricular septal rupture-related cardiogenic shock.

Eur Heart J Acute Cardiovasc Care 2018 Dec 10:2048872618817485. Epub 2018 Dec 10.

1 Intensive Cardiac Care Unit, Cardiology Department, Heart Disease Institute, Bellvitge University Hospital, Barcelona, Spain.

Background:: Current guidelines recommend emergency surgical correction in patients with post infarction ventricular septal rupture (PIVSR), but patients with multiorgan failure are commonly managed conservatively because of high surgical risk. We assessed characteristics and outcomes of operated PIVSR patients with or without the use of short-term ventricular assist devices (ST-VADs). We also assessed the impact of a ST-VAD on the performance of surgery. Read More

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http://dx.doi.org/10.1177/2048872618817485DOI Listing
December 2018
3 Reads

Multisite vascular disease in acute coronary syndromes: increased in-hospital mortality and no improvement over time.

Eur Heart J Acute Cardiovasc Care 2018 Dec 5:2048872618814708. Epub 2018 Dec 5.

7 Division of Cardiology, St. Gallen County Hospital, St. Gallen, Switzerland.

Introduction:: Limited data are available on the impact of multisite artery disease in patients with acute coronary syndromes. In particular, it is unknown whether the outcomes of those high-risk patients have improved over time. Therefore, we addressed the multisite artery disease patient population enrolled in the Swiss nationwide prospective acute coronary syndromes cohort study AMIS Plus over two decades. Read More

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http://dx.doi.org/10.1177/2048872618814708DOI Listing
December 2018
4 Reads

Renal dysfunction and cardiogenic shock complicating acute coronary syndromes.

Authors:

Eur Heart J Acute Cardiovasc Care 2018 Dec;7(8):687-688

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http://journals.sagepub.com/doi/10.1177/2048872618819089
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http://dx.doi.org/10.1177/2048872618819089DOI Listing
December 2018
14 Reads

Prognostic significance of emergency department bypass in stable and unstable patients with ST-segment elevation myocardial infarction.

Eur Heart J Acute Cardiovasc Care 2018 Nov 27:2048872618813907. Epub 2018 Nov 27.

7 Comprehensive Heart Failure Center Würzburg, Germany.

Background:: In ST-segment elevation myocardial infarction (STEMI) patients treated with percutaneous coronary intervention, direct transport from the scene to the catheterisation laboratory bypassing the emergency department has been shown to shorten times to reperfusion. The aim of this study was to investigate the effects of emergency department bypass on mortality in both haemodynamically stable and unstable STEMI patients.

Methods:: The analysis is based on a large cohort of STEMI patients prospectively included in the German multicentre Feedback Intervention and Treatment Times in ST-Elevation Myocardial Infarction (FITT-STEMI) trial. Read More

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http://dx.doi.org/10.1177/2048872618813907DOI Listing
November 2018
3 Reads

Pre-hospital risk assessment in suspected non-ST-elevation acute coronary syndrome: A prospective observational study.

Eur Heart J Acute Cardiovasc Care 2018 Nov 23:2048872618813846. Epub 2018 Nov 23.

1 Department of Cardiology, Isala Hospital, Zwolle, The Netherlands.

Background:: Pre-hospital risk stratification of non-ST-elevation acute coronary syndrome (NSTE-ACS) by the complete HEART score has not yet been assessed. We investigated whether pre-hospital risk stratification of patients with suspected NSTE-ACS using the HEART score is accurate in predicting major adverse cardiac events (MACE).

Methods:: This is a prospective observational study, including 700 patients with suspected NSTE-ACS. Read More

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http://dx.doi.org/10.1177/2048872618813846DOI Listing
November 2018
3 Reads

Long term survival after early unloading with Impella CP in acute myocardial infarction complicated by cardiogenic shock.

Eur Heart J Acute Cardiovasc Care 2018 Nov 20:2048872618815063. Epub 2018 Nov 20.

1 Department for Internal Medicine and Cardiology, Herzzentrum Dresden University Clinic, Technische Universität Dresden, Germany.

Background:: The use of percutaneous left ventricular assist devices in patients with acute myocardial infarction complicated by cardiogenic shock (AMICS) is evolving. The aim of the study was to assess the long-term outcome of patients with AMICS depending on early initiation of Impella CP support prior to a percutaneous coronary intervention (PCI).

Methods:: We retrospectively reviewed all patients who underwent PCI and Impella CP support between 2014 and 2016 for AMICS at our institution. Read More

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http://journals.sagepub.com/doi/10.1177/2048872618815063
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http://dx.doi.org/10.1177/2048872618815063DOI Listing
November 2018
24 Reads

Serum neprilysin and the risk of death in patients with out-of-hospital cardiac arrest of non-traumatic origin.

Eur Heart J Acute Cardiovasc Care 2018 Nov 19:2048872618815062. Epub 2018 Nov 19.

Department of Cardiology, Angiology, and Pneumology, University Hospital Heidelberg, Germany.

Background:: Early risk stratification remains an unmet clinical need in patients with in out-of-hospital cardiac arrest. We hypothesised that soluble neprilysin may represent a promising biomarker in patients with out-of-hospital cardiac arrest of non-traumatic origin and provide new pathobiological insight.

Methods:: This pilot study was a biomarker analysis from the Heidelberg Resuscitation Registry. Read More

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http://dx.doi.org/10.1177/2048872618815062DOI Listing
November 2018
12 Reads

Intramural haematoma of the ascending aorta - not so malignant after all?

Authors:
Udo Sechtem

Eur Heart J Acute Cardiovasc Care 2018 Nov 14:2048872618812397. Epub 2018 Nov 14.

Associate Professor, University of Tübingen, Germany.

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http://dx.doi.org/10.1177/2048872618812397DOI Listing
November 2018
8 Reads

Reperfusion cardiac arrhythmias and their relation to reperfusion-induced cell death.

Eur Heart J Acute Cardiovasc Care 2018 Nov 13:2048872618812148. Epub 2018 Nov 13.

1 Department of Cardiology, Maastricht University Medical Center, The Netherlands.

Reperfusion does not only salvage ischaemic myocardium but can also cause additional cell death which is called lethal reperfusion injury. The time of reperfusion is often accompanied by ventricular arrhythmias, i.e. Read More

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http://journals.sagepub.com/doi/10.1177/2048872618812148
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http://dx.doi.org/10.1177/2048872618812148DOI Listing
November 2018
10 Reads

Outcomes of medically managed patients with myocardial infarction.

Eur Heart J Acute Cardiovasc Care 2018 Nov 13:2048872618812135. Epub 2018 Nov 13.

1 Department of Medicine, University of Alberta, Canada.

Aims:: The purpose of this study was to compare outcomes associated with medical management of ST-elevation myocardial infarction and non-ST-elevation myocardial infarction patients presenting to hospitals with and without onsite catheterization facilities.

Methods: All patients ( n=25,921) with ST-elevation myocardial infarction ( n=10,563) or non-ST-elevation myocardial infarction ( n=15,358) in Alberta, Canada between April 2010-March 2016 were categorized according to availability of catheterization facilities at the hospital they presented to and their management strategy (medically managed without coronary angiography or medically managed after coronary angiography).

Results:: Overall, 51% presented to hospitals without catheterization facilities; and 34% were managed medically (18% without coronary angiography, and 16% after coronary angiography). Read More

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http://journals.sagepub.com/doi/10.1177/2048872618812135
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http://dx.doi.org/10.1177/2048872618812135DOI Listing
November 2018
9 Reads

Cardiac involvement in critically ill patients with leptospirosis: A prospective study using myocardial deformation imaging.

Eur Heart J Acute Cardiovasc Care 2018 Nov 8:2048872618809319. Epub 2018 Nov 8.

2 Division of Cardiology, University of Alberta, Canada.

Background:: Myocardial inflammation often complicates leptospirosis, a re-emerging global zoonosis. Leptospirosis associated myocardial dysfunction is equivocal and the pattern of cardiac involvement may not differ from that of sepsis associated myocarditis.

Methods:: We prospectively compared cardiac involvement in 113 intensive care unit patients with severe leptospirosis to 31 patients with sepsis syndrome using a comprehensive assessment comprising of clinical presentation, electrocardiography, two-dimensional echocardiography (with global longitudinal strain calculation), and cardiac biomarker evaluation. Read More

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http://dx.doi.org/10.1177/2048872618809319DOI Listing
November 2018
15 Reads

Survival after refractory cardiogenic shock is comparable in patients with Impella and veno-arterial extracorporeal membrane oxygenation when adjusted for SAVE score.

Eur Heart J Acute Cardiovasc Care 2018 Nov 8:2048872618799745. Epub 2018 Nov 8.

Department of Cardiothoracic Surgery, University Hospital Uppsala, Sweden.

Objectives:: Survival after different short-term mechanical circulatory support is difficult to compare because various systems are used and patient disease severity is most often not adjusted for. This study compares the outcome after the use of Impella and veno-arterial extracorporeal membrane oxygenation (VA-ECMO) in refractory cardiogenic shock, adjusted for disease severity through the survival after the VA-ECMO (SAVE) score.

Methods:: Patients with refractory shock treated with either VA-ECMO or Impella between January 2003 and August 2015 were included. Read More

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http://journals.sagepub.com/doi/10.1177/2048872618799745
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http://dx.doi.org/10.1177/2048872618799745DOI Listing
November 2018
12 Reads

Gender differences in patient and system delay for primary percutaneous coronary intervention: current trends in a Swiss ST-segment elevation myocardial infarction population.

Eur Heart J Acute Cardiovasc Care 2018 Nov 8:2048872618810410. Epub 2018 Nov 8.

1 Division of Cardiology, Triemli Hospital, Zurich, Switzerland.

Background:: Women with ST-segment elevation myocardial infarction (STEMI) experience greater delays for percutaneous coronary intervention-facilitated reperfusion than men. Whether women and men benefit equally from current strategies to reduce ischaemic time and whether there are gender differences in factors determining delays is unclear.

Methods:: Patient delay (symptom onset to first medical contact) and system delay (first medical contact to percutaneous coronary intervention-facilitated reperfusion) were compared between women ( n=967) and men ( n=3393) in a Swiss STEMI treatment network. Read More

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http://dx.doi.org/10.1177/2048872618810410DOI Listing
November 2018
16 Reads

Real-life use of left ventricular circulatory support with Impella in cardiogenic shock after acute myocardial infarction: 12 years AMC experience.

Eur Heart J Acute Cardiovasc Care 2018 Nov 7:2048872618805486. Epub 2018 Nov 7.

1 Heart Center; department of Cardiology, Amsterdam UMC, The Netherlands.

Aims:: Mortality in cardiogenic shock patients remains high. Short-term mechanical circulatory support with Impella can be used to support the circulation in these patients, but data from randomised controlled studies and 'real-world' data are sparse. The aim is to describe real-life data on outcomes and complications of our 12 years of clinical experience with Impella in patients with cardiogenic shock after acute myocardial infarction and to identify predictors of 6-month mortality. Read More

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http://dx.doi.org/10.1177/2048872618805486DOI Listing
November 2018
18 Reads

Atrial fibrillation detected initially during acute medical illness: A systematic review.

Eur Heart J Acute Cardiovasc Care 2018 Nov 7:2048872618799748. Epub 2018 Nov 7.

1 Population Health Research Institute, McMaster University, Canada.

Objective:: There is uncertainty about the incidence of and prognosis associated with atrial fibrillation that is documented for the first time in the setting of an acute stressor, such as surgery or medical illness. Our objective was to perform a systematic review of the incidence and long-term recurrence rates for atrial fibrillation occurring transiently with stress in the setting of acute medical illness.

Data Sources:: Medline, Embase and Cochrane Central to September 2017. Read More

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http://journals.sagepub.com/doi/10.1177/2048872618799748
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http://dx.doi.org/10.1177/2048872618799748DOI Listing
November 2018
23 Reads

Smoking is the dominating modifiable risk factor in younger patients with STEMI.

Eur Heart J Acute Cardiovasc Care 2018 Nov 2:2048872618810414. Epub 2018 Nov 2.

1 Department of Cardiology, Aarhus University Hospital, Denmark.

Aims:: Smoking is an important modifiable risk factor for myocardial infarction. It is unclear whether smoking habits at the time of an incident ST-segment elevation myocardial infarction (STEMI) differ across age groups and sex.

Methods And Results:: We included patients with incident STEMI registered in the Western Denmark Heart Registry from 2005 to 2015 ( n=9914). Read More

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http://dx.doi.org/10.1177/2048872618810414DOI Listing
November 2018
9 Reads

Right bundle branch block in patients with suspected myocardial infarction.

Eur Heart J Acute Cardiovasc Care 2018 Oct 26:2048872618809700. Epub 2018 Oct 26.

1 University Heart Center Hamburg, Germany.

Aims:: The new European Society of Cardiology guideline for ST-segment elevation myocardial infarction recommends that left and right bundle branch block should be considered equal for recommending urgent angiography in patients with suspected myocardial infarction. We aimed to evaluate this novel recommendation in two prospective studies of patients with suspected myocardial infarction.

Methods And Results:: We included 4067 patients presenting to the emergency department with suspected myocardial infarction. Read More

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http://dx.doi.org/10.1177/2048872618809700DOI Listing
October 2018
4 Reads

Atrial fibrillation occurring initially during acute medical illness: the heterogeneous nature of disease, outcomes and management strategies.

Eur Heart J Acute Cardiovasc Care 2018 Oct 24:2048872618801763. Epub 2018 Oct 24.

1 Institute of Cardiovascular Sciences, University of Birmingham, UK.

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http://dx.doi.org/10.1177/2048872618801763DOI Listing
October 2018
10 Reads

Sex-related response to bivalirudin and unfractionated heparin in patients with acute myocardial infarction undergoing percutaneous coronary intervention: A subgroup analysis of the VALIDATE-SWEDEHEART trial.

Eur Heart J Acute Cardiovasc Care 2018 Oct 23:2048872618803760. Epub 2018 Oct 23.

1 Department of Cardiology and Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.

Aims:: Our aim was to study the impact of sex on anticoagulant treatment outcomes during percutaneous coronary intervention in acute myocardial infarction patients.

Methods:: This study was a prespecified analysis of the Bivalirudin versus Heparin in ST-Segment and Non ST-Segment Elevation Myocardial Infarction in Patients on Modern Antiplatelet Therapy in the Swedish Web System for Enhancement and Development of Evidence-based Care in Heart Disease Evaluated according to Recommended Therapies Registry Trial (VALIDATE-SWEDEHEART) trial, in which patients with myocardial infarction were randomised to bivalirudin or unfractionated heparin during percutaneous coronary intervention. The primary outcome was the composite of death, myocardial infarction or major bleeding at 180 days. Read More

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http://dx.doi.org/10.1177/2048872618803760DOI Listing
October 2018
15 Reads

Outcomes of early and reversible renal impairment in patients with ST segment elevation myocardial infarction undergoing percutaneous coronary intervention.

Eur Heart J Acute Cardiovasc Care 2018 Oct 17:2048872618808456. Epub 2018 Oct 17.

Department of Cardiology, Tel-Aviv Sourasky Medical Center affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Israel.

Objective: Acute kidney injury (AKI) is a frequent complication in patients with ST segment elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI). While AKI occurring post-PCI has been well studied, the incidence and clinical significance of early renal impairment evident on hospital admission prior to PCI and which resolves towards discharge has not been investigated.

Methods: We retrospectively studied 2339 STEMI patients treated with primary PCI. Read More

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http://dx.doi.org/10.1177/2048872618808456DOI Listing
October 2018
4 Reads

Triage, diagnosis and management of acute chest pain syndromes, atypical and high-risk subtypes of acute coronary artery syndromes.

Eur Heart J Acute Cardiovasc Care 2018 Oct;7(7):589-590

Cardiovascular diseases, University of Antwerp, Belgium.

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http://dx.doi.org/10.1177/2048872618810252DOI Listing
October 2018
2 Reads

The efficacy and safety of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation and coronary artery disease: A meta-analysis of randomized trials.

Eur Heart J Acute Cardiovasc Care 2018 Oct 15:2048872618796990. Epub 2018 Oct 15.

TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, USA.

Background: Patients with atrial fibrillation and concomitant coronary artery disease (CAD) are at higher risk for myocardial infarction or cardiovascular death, often require antiplatelet therapy and are therefore exposed to an increased risk of bleeding. This meta-analysis aimed to compare the efficacy and safety profile of non-vitamin K antagonist oral anticoagulants (NOACs) with warfarin in patients with atrial fibrillation and concomitant CAD.

Materials And Methods: We performed a trial-level meta-analysis of CAD subgroups from four trials of NOAC versus warfarin in patients with atrial fibrillation, comparing the primary trial endpoints (efficacy: stroke or systemic embolic event; safety: International Society on Thrombosis and Haemostasis major bleeding) in patients with versus those without CAD, and used interaction testing to assess for treatment effect modification. Read More

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http://dx.doi.org/10.1177/2048872618796990DOI Listing
October 2018
6 Reads

Bivalirudin versus heparin monotherapy in non-ST-segment elevation myocardial infarction.

Eur Heart J Acute Cardiovasc Care 2018 Oct 3:2048872618805663. Epub 2018 Oct 3.

14 Department of Medical Sciences, Uppsala University, Sweden.

Background: The optimal anti-coagulation strategy for patients with non-ST-elevation myocardial infarction treated with percutaneous coronary intervention is unclear in contemporary clinical practice of radial access and potent P2Y12-inhibitors. The aim of this study was to investigate whether bivalirudin was superior to heparin monotherapy in patients with non-ST-elevation myocardial infarction without routine glycoprotein IIb/IIIa inhibitor use.

Methods: In a large pre-specified subgroup of the multicentre, prospective, randomised, registry-based, open-label clinical VALIDATE-SWEDEHEART trial we randomised patients with non-ST-elevation myocardial infarction undergoing percutaneous coronary intervention, treated with ticagrelor or prasugrel, to bivalirudin or heparin monotherapy with no planned use of glycoprotein IIb/IIIa inhibitors during percutaneous coronary intervention. Read More

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http://journals.sagepub.com/doi/10.1177/2048872618805663
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http://dx.doi.org/10.1177/2048872618805663DOI Listing
October 2018
6 Reads

Prasugrel or ticagrelor in patients with acute coronary syndrome and diabetes: a propensity matched substudy of RENAMI.

Eur Heart J Acute Cardiovasc Care 2018 Oct 1:2048872618802783. Epub 2018 Oct 1.

1 Department of Cardiology, University of Turin, Turin, Italy.

Introduction: The safety and efficacy of prasugrel and ticagrelor in patients with diabetes mellitus presenting with acute coronary syndrome and treated with percutaneous coronary intervention remain to be assessed.

Methods: All diabetes patients admitted for acute coronary syndrome and enrolled in the REgistry of New Antiplatelets in patients with Myocardial Infarction (RENAMI) were compared before and after propensity score matching. Net adverse cardiovascular events (composite of death, stroke, myocardial infarction and BARC 3-5 bleedings) and major adverse cardiovascular events (composite of death, stroke and myocardial infarction) were the co-primary endpoints. Read More

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http://journals.sagepub.com/doi/10.1177/2048872618802783
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http://dx.doi.org/10.1177/2048872618802783DOI Listing
October 2018
22 Reads

Sex differences in health outcomes at one year following acute myocardial infarction: A report from the China Patient-Centered Evaluative Assessment of Cardiac Events prospective acute myocardial infarction study.

Eur Heart J Acute Cardiovasc Care 2018 Oct 1:2048872618803726. Epub 2018 Oct 1.

3 NHC Key Laboratory of Clinical Research for Cardiovascular Medications, National Clinical Research Center of Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases, People's Republic of China.

Background: We examined sex differences in long-term health outcomes following acute myocardial infarction in China, including mortality, major adverse cardiac events and health status (symptoms, functioning, quality of life).

Methods: A total of 3415 acute myocardial infarction patients (23.2% women) aged ⩾18 years were enrolled across 10 geographic regions in China (2012-2014) in the China Patient-Centered Evaluative Assessment of Cardiac Events (PEACE) study. Read More

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http://journals.sagepub.com/doi/10.1177/2048872618803726
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http://dx.doi.org/10.1177/2048872618803726DOI Listing
October 2018
16 Reads

Impact of insulin-treated diabetes on cardiovascular outcomes following high-risk myocardial infarction.

Eur Heart J Acute Cardiovasc Care 2018 Sep 27:2048872618803701. Epub 2018 Sep 27.

3 Université de Lorraine, Centre d'Investigations Cliniques Plurithématique, France.

Background: Diabetes is associated with poor cardiovascular outcomes, and insulin-treated patients usually have a worse prognosis than non-insulin-treated subjects. The relationship between insulin treatment and outcomes in high-risk myocardial infarction patients has not been described in a large dataset.

Methods: To investigate the association between insulin-treated diabetes and long-term cardiovascular outcomes in patients with high-risk myocardial infarction, we used adjusted Cox models to compare cardiovascular mortality and hospitalisation among 28,771 patients grouped by diabetes status and insulin treatment from four randomised clinical trials (VALIANT, EPHESUS, OPTIMAAL, CAPRICORN) of acute myocardial infarction complicated by heart failure and/or left ventricular systolic dysfunction. Read More

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http://dx.doi.org/10.1177/2048872618803701DOI Listing
September 2018
3 Reads

Improving diagnosis, reperfusion therapy and secondary prevention in acute myocardial infarction.

Eur Heart J Acute Cardiovasc Care 2018 Sep;7(6):495-496

Cardiovascular diseases, University of Antwerp, Belgium.

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http://dx.doi.org/10.1177/2048872618804940DOI Listing
September 2018
10 Reads

The use of antiplatelet agents after an acute coronary syndrome in a large community Italian setting of more than 12 million subjects.

Eur Heart J Acute Cardiovasc Care 2018 Sep 13:2048872618801252. Epub 2018 Sep 13.

2 ReS (Research & Health) Foundation, Italy.

Background: Antiplatelet agents are the cornerstone of medical treatment in acute coronary syndromes. The aim of this study was to evaluate the clinical epidemiology of patients after an acute coronary syndrome treated with different antiplatelet agent regimens in a large real community setting.

Methods: The ARCO database, including more than 12 million inhabitants, was evaluated. Read More

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http://dx.doi.org/10.1177/2048872618801252DOI Listing
September 2018
8 Reads

Validation of simplified PESI score for identification of low-risk patients with pulmonary embolism: From the COMMAND VTE Registry.

Eur Heart J Acute Cardiovasc Care 2018 Sep 11:2048872618799993. Epub 2018 Sep 11.

1 Department of Cardiovascular Medicine, Kyoto University, Japan.

Background: The simplified pulmonary embolism severity index (sPESI) score has been reported to be useful in predicting 30-day mortality for patients with pulmonary embolism, which helps the identification of low-risk patients for early hospital discharge or home treatment. However, therapeutic decision-making should also be based on the risks of adverse events other than mortality.

Methods: The COMMAND VTE Registry is a multicentre registry enrolling consecutive patients with acute symptomatic venous thromboembolism in Japan between January 2010 and August 2014, and the current study population consisted of 1715 patients with pulmonary embolism. Read More

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http://dx.doi.org/10.1177/2048872618799993DOI Listing
September 2018
5 Reads

Growth differentiation factor-15 is a predictive biomarker in primary ventricular fibrillation: The RUTI-STEMI-PVF study.

Eur Heart J Acute Cardiovasc Care 2018 Sep 3:2048872618797599. Epub 2018 Sep 3.

1 Heart Institute, Hospital Universitari Germans Trias i Pujol, Spain.

Background: Primary ventricular fibrillation is an ominous complication of ST-segment elevation myocardial infarction, and proper biomarkers for risk prediction are lacking. Growth differentiation factor-15 is a marker of inflammation, oxidative stress and hypoxia with well-established prognostic value in ST-segment elevation myocardial infarction patients. We explored the predictive value of growth differentiation factor-15 in a subgroup of ST-segment elevation myocardial infarction patients with primary ventricular fibrillation. Read More

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http://dx.doi.org/10.1177/2048872618797599DOI Listing
September 2018
9 Reads

Octogenarian women with acute coronary syndrome present frailty and readmissions more frequently than men.

Eur Heart J Acute Cardiovasc Care 2018 Aug 31:2048872618798226. Epub 2018 Aug 31.

1 Cardiology Department, Servicio de Cardiología, Hospital Universitario Gregorio Marañón, Spain.

Background: A worse prognosis has been reported among women with acute coronary syndrome compared to men. Our aim was to address the role of frailty and sex in the management and prognosis of elderly patients with non-ST-segment elevation acute coronary syndrome.

Methods: A prospective registry in 44 Spanish hospitals including patients aged 80 years and older with non-ST-segment elevation acute coronary syndrome. Read More

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http://dx.doi.org/10.1177/2048872618798226DOI Listing
August 2018
17 Reads

Efficacy and safety of thrombus aspiration in ST-segment elevation myocardial infarction: an updated systematic review and meta-analysis of randomised clinical trials.

Eur Heart J Acute Cardiovasc Care 2019 Feb 30;8(1):24-38. Epub 2018 Aug 30.

Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Alma Mater Studiorum Università di Bologna, Italy.

Background:: The role of thrombus aspiration plus primary percutaneous coronary intervention in ST-segment elevation myocardial infarction remains controversial.

Methods:: We performed a meta-analysis of 25 randomised controlled trials in which 21,740 ST-segment elevation myocardial infarction patients were randomly assigned to thrombus aspiration plus primary percutaneous coronary intervention or primary percutaneous coronary intervention. Study endpoints were: death, myocardial infarction, stent thrombosis and stroke. Read More

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http://dx.doi.org/10.1177/2048872618795512DOI Listing
February 2019
11 Reads

Importance of elevated heart rate in the very early phase of ST-segment elevation myocardial infarction: Results from the DANAMI-3 trial.

Eur Heart J Acute Cardiovasc Care 2018 Aug 23:2048872618795515. Epub 2018 Aug 23.

1 Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Denmark.

Background: Elevated heart rate is associated with poor clinical outcome in patients with acute myocardial infarction. However, in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention the importance of elevated heart rate in the very early phase remains unknown. We evaluated the impact of elevated heart rate in the very early pre-hospital phase of ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention on cardiovascular magnetic resonance markers of reperfusion success and clinical outcome. Read More

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http://dx.doi.org/10.1177/2048872618795515DOI Listing
August 2018
10 Reads

Doppler echocardiography for assessment of systemic vascular resistances in cardiogenic shock patients.

Eur Heart J Acute Cardiovasc Care 2018 Aug 20:2048872618795514. Epub 2018 Aug 20.

1 Intensive Care Unit, Aix-Marseille University, France.

Objective: Impaired vascular tone plays an important role in cardiogenic shock. Doppler echocardiography provides a non-invasive estimation of systemic vascular resistance. The aim of the present study was to compare Doppler echocardiography with the transpulmonary thermodilution method for the assessment of systemic vascular resistance in patients with cardiogenic shock. Read More

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http://dx.doi.org/10.1177/2048872618795514DOI Listing
August 2018
10 Reads

Coronary endothelial function and spontaneous coronary artery dissection.

Eur Heart J Acute Cardiovasc Care 2018 Aug 20:2048872618795255. Epub 2018 Aug 20.

Department of Cardiovascular Diseases, Mayo Clinic, USA.

Objectives: To investigate the role of endothelial function in patients with previous spontaneous coronary artery dissection.

Background: Mechanisms underlying spontaneous coronary artery dissection, including a possible contribution from endothelial dysfunction, remain poorly understood.

Methods: This was a single center, retrospective study of patients with a prior spontaneous coronary artery dissection episode who underwent invasive endothelial function testing in the cardiac catheterization laboratory for evaluation of recurrent chest pain. Read More

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http://dx.doi.org/10.1177/2048872618795255DOI Listing
August 2018
29 Reads