Amphotericin B and terbinafine but not the azoles prolong survival in Galleria mellonella larvae infected with Madurella mycetomatis.
- Wendy Kloezen,
- Florianne Parel,
- Roger Brüggemann,
- Khalid Asouit,
- Marilyn Helvert-van Poppel,
- Ahmed Fahal,
- Johan Mouton,
- Wendy van de Sande
Med Mycol 2017 Sep 14. Epub 2017 Sep 14.
ErasmusMC Department of Medical Microbiology and Infectious Diseases Wytemaweg 80 3015 CE Rotterdam, The Netherlands.
Mycetoma is a tropical neglected disease characterized by large subcutaneous lesions in which the causative organisms reside in the form of grains. The most common causative agent is Madurella mycetomatis. Antifungal therapy often fails due to these grains, but to identify novel treatment options has been difficult since grains do not form in vitro. Read More