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PLoS Negl Trop Dis 2021 Jun 9;15(6):e0009488. Epub 2021 Jun 9.

Erasmus MC, University Medical Center Rotterdam, Department of Medical Microbiology and Infectious Diseases, Rotterdam, The Netherlands.

Mycetoma is a devastating neglected tropical infection of the subcutaneous tissue and most commonly caused by the fungus Madurella mycetomatis. Treatment of mycetoma consists of a combination of a long term antifungal treatment with itraconazole and surgery. However, treatment is associated with low success rates. Read More

SAGE Open Med 2021 31;9:20503121211020207. Epub 2021 May 31.

Department of Molecular Biology, Nile University, Khartoum, Sudan.

Objectives: Rheumatoid arthritis is a chronic inflammatory autoimmune disease. This study aimed to determine the association of interleukin-17A-197G/A polymorphism with rheumatoid arthritis in Sudanese patients.

Methods: A case-control study was conducted between March and December 2018. Read More

Trans R Soc Trop Med Hyg 2021 Jun 8. Epub 2021 Jun 8.

Department of Dermatovenereology, School of Medicine, College of Health Sciences, Addis Ababa University, Zambia st, Addis Ababa, Ethiopia 2380.

Background: The magnitude of various types of subcutaneous mycoses in Ethiopia is unknown.

Methods: We performed a 5-y retrospective review of confirmed cases at ALERT hospital dermatology clinics.

Result: Confirmed cases of subcutaneous mycoses included chromoblastomycosis (n=12) and mycetoma (n=8). Read More

Trans R Soc Trop Med Hyg 2021 May 26. Epub 2021 May 26.

Mycetoma Research Centre, Soba University Hospital, University of Khartoum, Khartoum, 11111, Sudan.

Background: Mycetoma is a neglected tropical disease that is reported worldwide and Sudan has the highest reported number of mycetoma infections across the globe. The incidence, prevalence and burden of mycetoma globally are not precisely known and its risk factors remain largely unelucidated.

Methods: This study aimed to identify the environmental predictors of fungal and bacterial mycetoma in Sudan and to identify areas of the country where these niche predictors are met. Read More

Front Microbiol 2021 27;12:641258. Epub 2021 Apr 27.

Laboratório de Taxonomia, Bioquímica e Bioprospecção de Fungos (LTBBF), Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil.

is a dematiaceous fungus that causes mainly chromoblastomycosis, but also disseminated infections such as phaeohyphomycosis and mycetoma. These diseases are extremely hard to treat and often refractory to current antifungal therapies. In this work, we have evaluated the effect of 1,10-phenanthroline-5,6-dione (phendione) and its metal-based complexes, [Ag (phendione)]ClO and [Cu(phendione)](ClO). Read More

Trans R Soc Trop Med Hyg 2021 May 13. Epub 2021 May 13.

Biomedical Research Institute, Darfur College, Nyala, Sudan.

Background: Mycetoma is a neglected tropical disease that attracts little attention in regard to research and publications and hence this study was undertaken to determine the trends and global scientific research output in mycetoma-related fields.

Methods: Mycetoma data were retrieved from the Web of Science (WoS) and Scopus databases. The MeSH Browser was used to extract relevant keywords. Read More

Indian J Med Microbiol 2021 Apr 2;39(2):256-258. Epub 2020 Nov 2.

Department of Dermatology, Institute of Post-Graduate Medical Education & Research, 244 AJC Bose Road, Kolkata, 700020, India.

Simultaneous double mycetoma is a rare presentation. Worldwide only three to four cases are found in literature. Here we report such an unusual case, to the best of our knowledge first documented case from India, where a 60 years old male farmer presented with double eumycetoma in different sites of same limb with discharge of black and white grains, which conventionally diagnosed as Madurella grisea from foot and Acremonium falciformi from buttock respectively. Read More

Foot (Edinb) 2021 Jun 22;47:101781. Epub 2021 Jan 22.

Department of Internal Medicine, PGIMER Dr RML Hospital, New Delhi, India.

Fungal osteomyelitis of calcaneus is rare in immunocompetent adults. A case of fungal osteomyelitis of calcaneus in a 19 year old immunocompetent female without any history of trauma caused by Acremonium sp is presented. The patient was treated with surgical debridement, autogenous iliac crest bone grafting and antifungal chemotherapy for 6 months. Read More

Indian Dermatol Online J 2021 Mar-Apr;12(2):298-301. Epub 2021 Feb 22.

Department of Microbiology, Safdarjung Hospital and Vardhaman Mahavir Medical College, Ansari Nagar, New Delhi, India.

is a recently identified organism and has rarely been reported to cause mycetoma. Here we report the case of a 40-year-old woman who presented with discharging sinuses and nodules for the past 7 years along with few discrete axillary lymph nodes. Cultures and Maldi-TOF MS (Matrix-assisted laser desorption/ionization-time of flight mass spectrometry) method identified the causative organism as The organism was acid-fast positive on modified Ziehl-Neelsen stain and Gram's stain revealed branched filamentous beaded gram-positive bacilli, while histopathology showed granulation tissue along with few ill-defined epithelioid cell granulomas, with giant cells. Read More

Indian Dermatol Online J 2021 Mar-Apr;12(2):285-289. Epub 2021 Feb 22.

Department of Ecology of Pathogen Agents, Hospital Manuel Gea González, Mexico City, Mexico.

Context: Mycetoma is a chronic, granulomatous disease caused by fungi (eumycetoma) or aerobic filamentous actinomycetes (actinomycetoma). is one of the most frequent actinomycetes.

Aim: The study aims to provide an update on clinical, diagnostic, therapeutic, and outcome data for patients with actinomycetoma in a single center in Mexico. Read More

FEMS Microbiol Lett 2021 May;368(8)

Facultad de Medicina, Departamento de Inmunologia Universidad Autonoma de Nuevo Leon, N.L. México.

Mycetoma is a chronic human infectious disease that produces severe deformation frequently in the lower extremities. Etiological agents include fungi (eumycetoma) and bacteria (actinomycetoma) that produce similar clinical and microscopic changes. The clinical appearance includes swelling, abscesses, ulcers, scars and sinuses that drain purulent material with microbe microcolonies. Read More

Clin Case Rep 2021 Apr 16;9(4):e04064. Epub 2021 Mar 16.

Department of Pathology Fattouma Bourguiba University Hospital Monastir Tunisia.

Mycetoma, commonly known as Madura foot, is a chronic granulomatous infection caused either by fungi (eumycetoma) known as actinomycete. This disease occurs preferentially in young adults, and it affects the foot in particular. We report a Tunisian case of mycetoma occurring in an old patient, particular by its cystic presentation. Read More

Clin Microbiol Infect 2021 Apr 26. Epub 2021 Apr 26.

Department of Microbiology, Amrita Institute of Medical Sciences & Research Centre, Amrita Vishwa Vidyapeetham, Ponekara, Kochi 682041, Kerala, India.

Mikrobiyol Bul 2021 Apr;55(2):256-264

University of Health Sciences, Sisli Hamidiye Etfal Research and Training Hospital, Department of Medical Microbiology, Istanbul, Turkey.

Scedosporium apiospermum complex members are opportunistic fungi that can be found in environments such as soil and polluted water. In this report, we aimed to present a case of mycetoma caused by Scedosporium apiospermum complex that developed in a 40-year-old female patient with immunocompetent system and diagnosed by fungal culture. In the anamnesis of the patient who admitted in 2015 with the complaint of more than one fistulized discharge wound, pain and swelling in the dorsal of the right hand and wrist; it was learned that her complaints started about 20 years ago with a slight swelling on the back of the wrist, and when it worsened, the abscess was drained and antibiotic treatment was initiated in a private surgical center. Read More

Exp Clin Transplant 2021 Apr 16. Epub 2021 Apr 16.

From the Department of Nephrology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, India.

In this case report, we describe the first case of Phialemonium obovatum infection involving the renal allograft in a recipient beyond 1 year after living renal transplant. The patient presented with a locally invasive mycetoma caused by this melanized fungus in the anterior abdominal wall, which extended during the hospital stay to involve the allograft. The fungus was identified by its characteristic micromorphological features present on potato dextrose agar and Sabourad dextrose agar and on subsequent slide cultures. Read More

J Mycol Med 2021 Apr 3;31(3):101135. Epub 2021 Apr 3.

Department of Microbiology, Government Medical College Hospital, Sector 32-B, Chandigarh, India.

Objective: Mycetoma is a slowly progressive, chronic granulomatous infection of skin and subcutaneous tissues with involvement of underlying fasciae and bones, usually affecting extremities. In India, among mycetoma, the eumycetoma constitutes about 35% of cases. Hereby, we report the first case of eumycetoma caused by uncommon fungus, Aspergillus candidus. Read More

Indian J Dermatol Venereol Leprol 2021 May-Jun;87(3):455

Department of Dermatology and Venereology All India Institute of Medical Sciences, New Delhi, India.

QJM 2021 Apr 12. Epub 2021 Apr 12.

Otolaryngology Department, Whipps Cross University Hospital- Barts Health NHS Trust, London, United Kingdom.

Intern Med 2021 Apr 12. Epub 2021 Apr 12.

Department of Otorhinolaryngology, Asahi General Hospital, Japan.

PLoS Negl Trop Dis 2021 Mar 25;15(3):e0009238. Epub 2021 Mar 25.

Laboratory of Parasitology and Mycology, Aristide Le Dantec University Hospital, Dakar, Senegal.

Mycetoma is a neglected tropical disease which is endemic in Senegal. Although this subcutaneous mycosis is most commonly found on the foot, extrapodal localisations have also been found, including on the leg, knee, thigh, hand, and arm. To our knowledge, no case of blood-spread eumycetoma has been reported in Senegal. Read More

Australas J Dermatol 2021 Mar 24. Epub 2021 Mar 24.

Laboratory of Pathology of Infectious Diseases (LIM-50), Faculdade de Medicina, Hospital das Clinicas HCFMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil.

Mycetoma is a progressively mutilating infectious disease of the subcutaneous tissue that affects the skin and deep structures, which is poorly responsive to chemotherapy. Here, we report a skin mycetoma caused by Paecilomyces variotii, an uncommon fungus of human infections, and the therapeutic approach that resulted in a complete cure of the patient. Read More

Trans R Soc Trop Med Hyg 2021 Apr;115(4):328-336

Erasmus MC, University Medical Centre Rotterdam, Department of Medical Microbiology and Infectious Diseases, Wytemaweg 80, 3015 CE, Rotterdam, the Netherlands.

Background: Mycetoma is a neglected disease, which is socioeconomically important, and with the possibility of permanent disability in infected persons if not treated early. This is especially true in resource-limited settings such as West Africa, where there is a lack of facilities and skilled personnel to make a definitive laboratory diagnosis. Countries in West Africa have similar climatic conditions to Sudan. Read More

Trans R Soc Trop Med Hyg 2021 Apr;115(4):364-374

Mycetoma Research Center, Soba University Hospital, University of Khartoum, Sudan.

Background: Currently there is a wide knowledge gap in our understanding of mycetoma epidemiological characteristics, including the infection route.

Methods: A cross-sectional descriptive epidemiological study was carried out to determine the role of exposure to animals and insects such as ticks in the transmission of eumycetoma in two adjacent villages at eastern Sudan.

Results: Significant differences were found between the two villages in the level of contact and exposure to animals and ticks, the percentages of people bitten by ticks, participation in cleaning animal pens and knowledge of the medical importance of ticks. Read More

Trans R Soc Trop Med Hyg 2021 Apr;115(4):337-339

Clinical Microbiology Laboratory, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Av. Vasco de Quiroga 15, Belisario Domínguez Sección XVI, Tlalpan, 14080 México City, México.

Background: Actinomycetoma is a chronic granulomatous infection that follows traumatic implantation. Thoracic actinomycetoma (TA) is rare and may lead to severe complications.

Methods: A retrospective study of cases of TA diagnosed from 1985 to 2019 was carried out. Read More

Trans R Soc Trop Med Hyg 2021 Apr;115(4):295-296

University of Khartoum, Mycetoma Research Centre, Sudan.

J Infect Dev Ctries 2021 03 7;15(2):204-208. Epub 2021 Mar 7.

Mycetoma Research Centre, University of Khartoum, Khartoum, Sudan.

The steadily growing COVID-19 pandemic is challenging health systems worldwide including Sudan. In Sudan, the first COVID-19 case was reported on 13th March 2020, and up to 11 November 2020 there were 14,401 confirmed cases of which 9,535 cases recovered and the rest 3,750 cases were under treatment. Additionally, 1,116 deaths were reported, indicating a relatively high case fatality rate of 7. Read More

Trans R Soc Trop Med Hyg 2021 Apr;115(4):431-435

Mycetoma Research Centre, University of Khartoum, Khartoum, Sudan.

Mycetoma is a chronic granulomatous disease that significant affects the subcutaneous tissue and deep structures. Mycetoma is caused by certain fungi (eumycetoma) or higher bacteria (actinomycetoma). The clinical presentation is variable and depends on the causative agent. Read More

Trans R Soc Trop Med Hyg 2021 Apr;115(4):375-382

Mycetoma Research Center, University of Khartoum, Khartoum, Sudan.

Background: Mycetoma is a unique neglected tropical disease caused by a substantial number of different fungi or bacteria. Many of the disease's epidemiological characteristics are an enigma. Hence, understanding the spatial geographic distribution of mycetoma may clarify the association between the local environmental indicators, the spatial geographical distribution of mycetoma and its epidemiology. Read More

Int J Surg Case Rep 2021 Mar 21;80:105679. Epub 2021 Feb 21.

Department of Surgery, Kibuye Referral Hospital, Rwanda.

Introduction And Importance: Abdominal actinomycetoma is a rare and often a missed diagnosis by most of clinicians due to its rarity and different clinical presentations. It is caused by Actinomyces speces which are gram positive bacilli and normal commensal inhabitants of the human bronchial and gastrointestinal tracts. A. Read More

Trans R Soc Trop Med Hyg 2021 Apr;115(4):315-319

Mycetoma Research Center, Khartoum, Sudan.

Background: Mycetoma is a chronic, progressive and destructive inflammatory disease that affects the skin, subcutaneous and other tissues. The objective of this study was to identify all cases of mycetoma diagnosed in three health facilities in Nouakchott, Mauritania during 2016-2018.

Methods: This retrospective hospital-based study was conducted at the Dermatology, Orthopedics, Mycology and Pathology departments of the National Hospital Center of Nouakchott, the Military Hospital of Nouakchott and the National Institute for Research in Public Health of Nouakchott. Read More