2,568 results match your criteria Eumycetoma Fungal Mycetoma


Frequency distribution of IL-17A G197A (rs2275913) and IL-17F A7488G (rs763780) polymorphisms among healthy Sudanese population.

BMC Res Notes 2020 Jul 2;13(1):317. Epub 2020 Jul 2.

Department of Molecular Biology, Institute of Parasitology, University of Leipzig, Leipzig, Germany.

Objectives: IL-17A G197A and IL-17F A7488G polymorphisms has been identified to be associated with the susceptibility to many diseases. This study aimed to investigate the frequency distribution of IL-17A G197A and IL-17F A7488G polymorphisms among healthy Sudanese population. A descriptive cross-sectional hospital-based molecular study conducted in different sites throughout Sudan. Read More

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http://dx.doi.org/10.1186/s13104-020-05165-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330939PMC

Looking for NTDs in the skin; an entry door for offering patient centered holistic care.

J Infect Dev Ctries 2020 Jun 29;14(6.1):16S-21S. Epub 2020 Jun 29.

Institute of Tropical Medicine, Antwerp, Belgium.

Introduction: The majority of neglected tropical diseases (NTDs) have established primary skin manifestations or associated clinical feature. Skin NTDs often result in physical impairment and disfigurement, which can lead to disability. Skin diseases have been proposed as an entry point for integrated NTDs control. Read More

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http://dx.doi.org/10.3855/jidc.11707DOI Listing

Slowly growing plantar mass in a 40-year-old immigrant.

JAAD Case Rep 2020 Jul 11;6(7):625-627. Epub 2020 May 11.

Department of Dermatology, University of Florida College of Medicine, Gainesville, Florida.

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http://dx.doi.org/10.1016/j.jdcr.2020.04.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317695PMC

Appendiceal actinomycosis mimicking appendiceal tumor, appendicitis or inflammatory bowel disease.

J Pathol Transl Med 2020 Jun 26. Epub 2020 Jun 26.

Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Appendiceal actinomycosis is very rare and its diagnosis is often difficult even in surgically resected specimens. Here we report two cases of appendiceal actinomycosis confirmed by pathologic examination of surgically resected specimens. Characteristic histologic features included transmural chronic inflammation with Crohn-like lymphoid aggregates and polypoid mucosal protrusion into cecal lumen through fibrous expansion of the submucosa. Read More

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http://dx.doi.org/10.4132/jptm.2020.05.17DOI Listing

Immunohistochemical expression of interleukin-17 and hormonal receptors in benign and malignant breast lesions.

BMC Res Notes 2020 Jun 23;13(1):300. Epub 2020 Jun 23.

Department of Histopathology and Cytology, Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan.

Objectives: IL17 is a critical pro-inflammatory cytokine that is involved in inflammation, multidrug resistance and growth persistence pathways in cancer. This study is aiming at studying the expression of IL17 and hormonal receptors expression in benign and malignant breast lesions using immunohistochemical staining methods.

Results: A total of 137 cases of breast lesions were studied, 97 (70. Read More

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http://dx.doi.org/10.1186/s13104-020-05146-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310502PMC

Successful Terbinafine Treatment for Cutaneous Phaeohyphomycosis Caused by Trematosphaeria grisea in a Heart Transplanted Man: Case Report and Literature Review.

Mycopathologia 2020 Jun 19. Epub 2020 Jun 19.

Parasitologie - Mycologie et Médecine Tropicale, Hôpital Bretonneau, CHU de Tours, 2 Boulevard Tonnellé, 37044, Tours, France.

Phaeohyphomycosis is a chronic infectious disease caused by dematiaceous fungi. It is characterized by the presence of pigmented septate mycelia within tissues. In the case of superficial infection, the lesion(s) chronically evolve(s) toward painless pseudo-tumor(s) of the soft parts. Read More

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http://dx.doi.org/10.1007/s11046-020-00467-4DOI Listing

Immunohistochemical expression of Cyclin D1 among Sudanese patients diagnosed with benign and malignant prostatic lesions.

BMC Res Notes 2020 Jun 17;13(1):295. Epub 2020 Jun 17.

Department of Cytology and Histopathology, Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan.

Objectives: Prostate cancer (PC) is common cancer worldwide. Several markers have been developed to differentiate between benign prostatic hyperplasia (BPH) from PC. A descriptive retrospective hospital-based study aimed at determining the expression of Cyclin D1 in BPH and PC. Read More

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http://dx.doi.org/10.1186/s13104-020-05138-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302005PMC

Mycetoma due to .

IDCases 2020 30;21:e00857. Epub 2020 May 30.

Department of Radiology, Teaching Hospital, Karapitiya, Sri Lanka.

Mycetoma is a progressive destructive disease causing severe disability, if untreated, in otherwise healthy people. Susceptible populations are usually adult males and disease is characterized by the triad of tumor formation, presence of grains and draining sinuses. Here, we report a case of mycetoma of a young female, manifested only as a painful swelling over left ankle which was initially suspected as a malignancy. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283137PMC

A case of mycetoma-like chromoblastomycosis in Qatar.

IDCases 2020 30;21:e00853. Epub 2020 May 30.

Department of Infectious Diseases, Qatar.

Chromoblastomycosis is one of the neglected tropical mycoses associated with chronic infection of the skin and subcutaneous tissues. We report a case of 49-year-old patient originally from India presented with a mycetoma-like lesion in his right foot which was slowly progressing over three-year period. The diagnosis of chromoblastomycosis was confirmed following surgical excision and identification of the unique histological pathology of muriform bodies. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283144PMC

Mycetoma and Chromoblastomycosis: Perspective for Diagnosis Improvement Using Biomarkers.

Molecules 2020 Jun 2;25(11). Epub 2020 Jun 2.

Malaria Research Unit, University Lyon, ICBMS, UMR 5246 CNRS INSA CPE, Campus Lyon-Tech La Doua, F-69100 Lyon, France.

Background: Mycetoma and chromoblastomycosis are both chronic subcutaneous infectious diseases that pose an obstacle to socioeconomic development. Besides the therapeutic issue, the diagnosis of most neglected tropical diseases (NTD) is challenging. Confirmation using direct microscopy and culture, recognized as WHO essential diagnostic tests, are limited to specialized facilities. Read More

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http://dx.doi.org/10.3390/molecules25112594DOI Listing

Fungal ball of the maxillary sinus and the risk of persistent sinus dysfunction after simple antrostomy.

Am J Otolaryngol 2020 Jul - Aug;41(4):102541. Epub 2020 May 8.

Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia; Rhinology and Skull Base Research Group, Applied Medical Research Centre, University of New South Wales, Sydney, Australia.

Background: Maxillary sinus fungal ball is a common cause of unilateral maxillary sinusitis. Fungal balls or mycetomas are primarily treated with surgery to remove the fungus. However, this assumes the pre-fungal ball sinus cavity was normal and post-surgery patients may suffer from mucostasis in the sinus cavity with persistent symptoms. Read More

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http://dx.doi.org/10.1016/j.amjoto.2020.102541DOI Listing

Nocardia Infections: Ten Years Experience from a Tertiary Health Care Center in North India (2007-2016).

Infect Disord Drug Targets 2020 May 16. Epub 2020 May 16.

Department of Microbiology, Government Medical College Hospital, Sector 32, Chandigarh. India.

Background: Nocardia species are important cause of infections in humans but are underreported due to missed diagnosis as well as misdiagnosis. Majority of the literature on these infections consists of case reports or series with few articles describing high number of cases.

Objective: To study the epidemiology of Nocardia infections in a tertiary care center. Read More

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http://dx.doi.org/10.2174/1871526520666200516161940DOI Listing

Compressive epidural collection as an unusual complication of FESS for a pediatric mycetoma.

Childs Nerv Syst 2020 May 15. Epub 2020 May 15.

Department of Neurosurgery, University of Virginia, Charlottesville, VA, USA.

Functional endoscopic sinus surgery (FESS) is a treatment of choice for fungal sinus ball (mycetoma), which is considered safe with a very low major complication rate. We present an unusual case of a 12-year-old female, who underwent FESS for a sphenoid sinus mycetoma and which was complicated by an acute, compressive epidural fluid collection. This presumably resulted from sinus irrigation in the setting of an under-appreciated skull base and mucosal defects causing a ball-valve effect. Read More

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http://dx.doi.org/10.1007/s00381-020-04651-1DOI Listing

Climate, soil type, and geographic distribution of actinomycetoma cases in Northeast Mexico: A cross-sectional study.

PLoS One 2020 8;15(5):e0232556. Epub 2020 May 8.

Servicio de Dermatología, Facultad de Medicina y Hospital Universitario, Universidad Autónoma de Nuevo León, Monterrey, Mexico.

Background: Mycetoma is a chronic, granulomatous infection of subcutaneous tissue, that may involve deep structures and bone. It can be caused by bacteria (actinomycetoma) or fungi (eumycetoma). There is an epidemiological association between mycetoma and the environment, including rainfall, temperature and humidity but there are still many knowledge gaps in the identification of the natural habitat of actinomycetes, their primary reservoir, and their precise geographical distribution. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0232556PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7209257PMC

Voriconazole resistance genes in Aspergillus flavus clinical isolates.

J Mycol Med 2020 Jun 26;30(2):100953. Epub 2020 Mar 26.

Department of Medical Genetics, Tehran University of Medical Sciences, Tehran, Iran.

Objective: The present study was designed to discover novel biomarkers involved in voriconazole resistance in clinical isolates of Aspergillus flavus.

Materials And Methods: Two voriconazole non-wild-type and two voriconazole-wild-type A. flavus clinical isolates were selected to evaluate possible molecular mechanism involved in A. Read More

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http://dx.doi.org/10.1016/j.mycmed.2020.100953DOI Listing

Host genetic susceptibility to mycetoma.

PLoS Negl Trop Dis 2020 04 30;14(4):e0008053. Epub 2020 Apr 30.

The Mycetoma Research Centre, University of Khartoum, Khartoum, Sudan.

Mycetoma is one of the badly neglected tropical diseases, characterised by subcutaneous painless swelling, multiple sinuses, and discharge containing aggregates of the infecting organism known as grains. Risk factors conferring susceptibility to mycetoma include environmental factors and pathogen factors such as virulence and the infecting dose, in addition to host factors such as immunological and genetic predisposition. Epidemiological evidence suggests that host genetic factors may regulate susceptibility to mycetoma and other fungal infections, but they are likely to be complex genetic traits in which multiple genes interact with each other and environmental factors, as well as the pathogen, to cause disease. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192380PMC

Mycetoma in Uganda: A neglected tropical disease.

PLoS Negl Trop Dis 2020 04 29;14(4):e0008240. Epub 2020 Apr 29.

Department of Pathology, School of Biomedical Sciences, College of Health Sciences, Makerere University, Kampala, Uganda.

Mycetoma is considered a neglected tropical disease globally. However, data on its burden and the associated complications in Uganda are limited. Hence we aimed to estimate its burden in Uganda. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190103PMC

Mycetoma epidemiology, diagnosis management, and outcome in three hospital centres in Senegal from 2008 to 2018.

PLoS One 2020 24;15(4):e0231871. Epub 2020 Apr 24.

Service de Parasitologie-Mycologie, Faculté de médecine, Université Cheikh Anta Diop de Dakar, Dakar, Sénégal.

Mycetoma is a neglected tropical disease caused by various actinomycetes or fungi. The disease is characterized by the formation of tumor like-swellings and grains. Senegal is an endemic country where mycetoma cases are under-or misdiagnosed due to the lack of capacities and knowledge among health workers and the community; and where the management of eumycetoma, burdened by a high amputation rate, is currently inadequate. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0231871PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182189PMC

Successful Treatment of Recalcitrant Actinomycetoma of Gluteal Area with Combined Medical Treatment and Surgical Excision with Graft Reconstruction.

Oman Med J 2020 Mar 14;35(2):e111. Epub 2020 Apr 14.

Dermtology Department, Al Nahdha Hospital, Muscat, Oman.

Mycetoma, formerly known as Madura foot, is a chronic, localized, gradually increasing in size, granulomatous exogenous infection of the skin and subcutaneous tissue with risks of bone and visceral involvement. It is unevenly found worldwide but it is endemic in tropical and subtropical countries. Two groups of mycetoma exist with similar clinical presentation; eumycetoma due to true fungi, and actinomycetoma due to aerobic bacteria from actinomycomycetes species. Read More

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http://dx.doi.org/10.5001/omj.2020.29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157440PMC

Draft Genome Sequences of Three Clinical Isolates of Madurella mycetomatis, the Major Cause of Black-Grain Mycetoma.

Microbiol Resour Announc 2020 Apr 16;9(16). Epub 2020 Apr 16.

Department of Microbiology, Faculty of Medical Laboratory Sciences, Khartoum University, Khartoum, Sudan.

The draft genomes of three fungal clinical isolates of from patients with mycetoma are presented. No finished genome is currently available for this important fungus. Therefore, the addition of these new draft genomes will help us better understand the diversity and pathogenicity of this important species. Read More

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http://dx.doi.org/10.1128/MRA.01533-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163029PMC

Pseudomycetoma of the scalp caused by Microsporum canis.

An Bras Dermatol 2020 May - Jun;95(3):372-375. Epub 2020 Mar 19.

Clinic of Dermatology, Faculdade de Ciências Médicas, Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brazil. Electronic address:

Pseudomycetoma is an extremely rare deep mycosis, caused by dermatophytic fungi that penetrate the tissue from infected follicles of tinea capitis. Both clinically and histopathology are similar to eumycetoma, being distinguished through the isolation of the fungus, which in the case of pseudomycetoma can be Microsporum spp. or Trichophyton spp. Read More

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http://dx.doi.org/10.1016/j.abd.2019.07.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253879PMC

Proteomic analysis of the processes leading to Madurella mycetomatis grain formation in Galleria mellonella larvae.

PLoS Negl Trop Dis 2020 04 8;14(4):e0008190. Epub 2020 Apr 8.

Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands.

Mycetoma is a neglected chronic and granulomatous infection primarily associated with the fungal pathogen Madurella mycetomatis. Characteristic of this infection is the formation of grains. However, the processes leading to grain formation are not known. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141616PMC

Successful Limb Salvage in a Case of Advanced Long-Standing Eumycetoma of the Foot Using Adjunctive Local Amphotericin B Delivery Through Bioabsorbable Beads.

Indian J Orthop 2020 Apr 10;54(2):224-227. Epub 2020 Feb 10.

3Division of Medical Mycology, Department of Microbiology, V.P. Chest Institute, University of Delhi, Delhi, India.

Mycetoma is a chronic, granulomatous infection mainly involving the foot and is caused either by bacteria (actinomycetoma) or fungi (eumycetoma). Eumycetoma is notoriously resistant, posing a therapeutic challenge. There are no specific treatment guidelines but generally a combination of systemic antifungals and local surgical treatment is the accepted standard. Read More

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http://dx.doi.org/10.1007/s43465-019-00031-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096342PMC

Diagnostic implications of mycetoma derived from Madurella pseudomycetomatis isolates from Mexico.

J Eur Acad Dermatol Venereol 2020 Mar 31:e16402. Epub 2020 Mar 31.

Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.

Background: At the dermatology service of the General Hospital of Mexico City, Mexico, two patients, father and son, with black-grain mycetoma were seen. The grains were isolated, and the cultured fungi were identified as Madurella mycetomatis based on morphology. Using the M. Read More

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http://dx.doi.org/10.1111/jdv.16402DOI Listing

Non-surgical treatment options for pulmonary aspergilloma.

Respir Med 2020 Apr 19;164:105903. Epub 2020 Feb 19.

Department of Interventional Radiology, Cleveland Clinic Foundation, Cleveland, OH, USA.

Aspergilloma, also known as mycetoma or fungus ball, is the most common manifestation of pulmonary involvement by Aspergillus species. The fungal ball typically forms within preexisting cavities of the lungs. Diagnosis requires both radiographic evidence along with serologic or microbiologic evidence of Aspergillus species involvement. Read More

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http://dx.doi.org/10.1016/j.rmed.2020.105903DOI Listing

Skin Disease in the Tropics and the Lessons that can be Learned from Leprosy and Other Neglected Diseases.

Authors:
Roderick J Hay

Acta Derm Venereol 2020 Apr 20;100(9):adv00113. Epub 2020 Apr 20.

The International Foundation for Dermatology, Willan House, 4 Fitzroy sqaure, London W1T 5HQ, United Kingdom.

Skin disease is a common illness in most tropical regions where the pattern of clinical, presentations is dominated by infections. Along with common diseases such as pyodermas and fungal infections, a group of conditions known collectively as the neglected tropical diseases of the skin or Skin NTDs, which are the targets for worldwide control or elimination are also seen in health care facilities. These diseases range from the common, such a scabies, to those that are less frequent including leprosy and mycetoma. Read More

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http://dx.doi.org/10.2340/00015555-3469DOI Listing

Actinomycetoma caused by : first reported case of human infection.

New Microbes New Infect 2020 Mar 14;34:100658. Epub 2020 Feb 14.

Dermatology Department, University of French Guiana, Cayenne, French Guiana.

Bacteria of the genus are rarely involved in human infections. We report here the case of a 30-year-old man from Guinea Buissau with mycetoma of the foot. 16S DNA sequencing after surgical biopsy identified . Read More

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http://dx.doi.org/10.1016/j.nmni.2020.100658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078390PMC

Case of cutaneous botryomycosis in an 8-year-old immunocompetent boy with a review of the published work.

J Dermatol 2020 May 15;47(5):542-545. Epub 2020 Mar 15.

Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Botryomycosis is a rare chronic suppurative granulomatous infection caused by several genera of non-filamentous bacteria. The clinical and histopathological findings are similar to those of mycetoma caused by true fungi or aerobic actinomycetes. Botryomycosis is divided into cutaneous and visceral disease, with the cutaneous form being more common. Read More

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http://dx.doi.org/10.1111/1346-8138.15308DOI Listing

Acremonium nail bed mycetoma masquerading as subungual squamous cell carcinoma.

Dermatol Online J 2020 Jan 15;26(1). Epub 2020 Jan 15.

Department of Dermatology, University General Hospital of Patras.

Acremonium is a large fungal genus that is comprised of approximately 150 species, found ubiquitously in nature. Although the majority are recognized as being saprophytes in soil and pathogens of plants, several species are emerging as causative agents of a variety of human infections, including mycetomas. Herein, we present a young man that was referred to our department with a painful subungual mass that developed following traumatic inoculation of Acremonium spp. Read More

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January 2020

[Uncommon signs of mycetoma].

Pan Afr Med J 2019 26;34:163. Epub 2019 Nov 26.

Service de Dermatologie et Maladies Infectieuses, Hôpital de Référence de Talangaï, Brazzaville, Congo.

Mycetoma is a chronic inflammatory process during which exogenous fungal or actinomycosic agents produce grains. The infection involves the skin, the subcutaneous tissues, the muscles and the bones. We report the case of a 39-year old woman, a teacher, living in Brazzaville, who had regularly resided in the village. Read More

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http://dx.doi.org/10.11604/pamj.2019.34.163.20300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046107PMC

Soft tissue mycetoma: "Dot-in-circle" sign on magnetic resonance imaging.

Radiol Case Rep 2020 May 22;15(5):467-473. Epub 2020 Feb 22.

Department of Radiology, Musculoskeletal Imaging Division, University of Washington, UW Radiology-Roosevelt Clinic, 4245 Roosevelt Way NE, Box 354755, Seattle, WA 98105, USA.

A 36-year-old Mexican female with a slowly growing foot mass was referred to orthopedic surgery clinic for further evaluation. Foot magnetic resonance imaging revealed an infiltrative soft tissue mass along the dorsal aspect of the fourth metatarsal. T2-weighted images revealed multiple central low-signal "dots" surrounded by areas of bright signal intensity, known as the "dot-in-circle" sign, which is highly specific for mycetoma. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.01.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036743PMC

Clinical characteristics and treatment of actinomycetoma in northeast Mexico: A case series.

PLoS Negl Trop Dis 2020 02 25;14(2):e0008123. Epub 2020 Feb 25.

Servicio de Dermatología, Facultad de Medicina y Hospital Universitario "Dr. José Eleuterio González", Universidad Autónoma de Nuevo León, Monterrey, México.

Background: Mycetoma is a neglected tropical disease characterized by nodules, scars, abscesses, and fistulae that drain serous or purulent material containing the etiological agent. Mycetoma may be caused by true fungi (eumycetoma) or filamentous aerobic bacteria (actinomycetoma). Mycetoma is more frequent in the so-called mycetoma belt (latitude 15° south and 30° north around the Tropic of Cancer), especially in Sudan, Nigeria, Somalia, India, Mexico, and Venezuela. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059949PMC
February 2020

Aspergilloma Superimposed Infection on Lymphoid Interstitial Pneumonia.

Case Rep Emerg Med 2020 18;2020:3151036. Epub 2020 Jan 18.

Department of Emergency Medicine, Rowan University SOM/Jefferson-Stratford, Stratford, NJ, USA.

We describe a case of a 27-year-old female without any prior underlying immunodeficiency syndromes who presented with hemoptysis secondary to subacute invasive pulmonary aspergillosis and subsequently diagnosed with lymphoid interstitial pneumonia (LIP). CT chest demonstrated bilateral interstitial disease with patchy opacities and multiple large cysts and bullae. Diagnosis was confirmed histologically after surgical lung resection of the mycetoma containing cavitation. Read More

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http://dx.doi.org/10.1155/2020/3151036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995327PMC
January 2020

PULMONARY ASPERGILLOMA.

QJM 2020 Feb 20. Epub 2020 Feb 20.

Department of Medicine, PMMPHAMB Hospital, Jalan Sungai Basong, Tutong.

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http://dx.doi.org/10.1093/qjmed/hcaa032DOI Listing
February 2020

Diversity and geographic distribution of soil streptomycetes with antagonistic potential against actinomycetoma-causing Streptomyces sudanensis in Sudan and South Sudan.

BMC Microbiol 2020 Feb 12;20(1):33. Epub 2020 Feb 12.

Department of Soil Ecology, Helmholtz-Centre for Environmental Research GmbH - UFZ, Theodor-Lieser-Str. 4, 06120, Halle, Germany.

Background: Production of antibiotics to inhibit competitors affects soil microbial community composition and contributes to disease suppression. In this work, we characterized whether Streptomyces bacteria, prolific antibiotics producers, inhibit a soil borne human pathogenic microorganism, Streptomyces sudanensis. S. Read More

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http://dx.doi.org/10.1186/s12866-020-1717-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017484PMC
February 2020

Mycetoma-like phaeohyphomycosis treated with terbinafine.

IDCases 2020 28;19:e00705. Epub 2020 Jan 28.

Department of Pathology, University of Campinas (UNICAMP) Medical School, Campinas, Sao Paulo, Brazil.

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http://dx.doi.org/10.1016/j.idcr.2020.e00705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996009PMC
January 2020

[Recidives of Mycetoma after Amputation in Dakar (Senegal)].

Bull Soc Pathol Exot 2019 ;112(4):195-201

Service orthopédie-traumatologie, Hôpital Aristide Le Dantec, Dakar, Sénégal.

The treatment of fungal mycetoma is essentially surgical. This carcinological-like surgery consists of amputation in case of bone involvement. The recurrences after amputation are rare and address the problem of the operative indication. Read More

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http://dx.doi.org/10.3166/bspe-2019-0103DOI Listing
January 2019

Actinomycetoma Caused by Actinomadura mexicana, A Neglected Entity in the Caribbean.

Emerg Infect Dis 2020 Feb;26(2):379-380

Mycetoma is a chronic infection that is slow to develop and heal. It can be caused by fungi (eumycetoma) or bacteria (actinomycetoma). We describe a case of actinomycetoma caused by Actinomadura mexicana in the Caribbean region. Read More

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http://dx.doi.org/10.3201/eid2602.191005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986842PMC
February 2020

MR Findings of Fungus Ball: Significance of High Signal Intensity on T1-Weighted Images.

J Korean Med Sci 2020 Jan 20;35(3):e22. Epub 2020 Jan 20.

Department of Radiology, Seoul National University Hospital Healthcare System Gangnam Center, Seoul National University College of Medicine, Seoul, Korea.

Background: Central dark-signal intensity with high-signal, hypertrophic mucosal wall of paranasal sinuses on T2-weighted images (T2WI) is a characteristic magnetic resonance imaging (MRI) feature of sinonasal fungus ball. However, this finding is usually interpreted as non-fungal chronic sinusitis with central normal sinus air. In addition, T1-weighted images (T1WI) and T2WI are basic sequences of all magnetic resonance (MR) examinations. Read More

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http://dx.doi.org/10.3346/jkms.2020.35.e22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970076PMC
January 2020

Madurella real-time PCR, a novel approach for eumycetoma diagnosis.

PLoS Negl Trop Dis 2020 01 15;14(1):e0007845. Epub 2020 Jan 15.

Westerdijk Fungal Biodiversity Institute, Utrecht, The Netherlands.

The genus Madurella comprising four species, M. fahalii, M. mycetomatis, M. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986762PMC
January 2020

A Comparative Study on Phenotypic versus ITS-Based Molecular Identification of Dermatophytes Isolated in Dakar, Senegal.

Int J Microbiol 2019 18;2019:6754058. Epub 2019 Dec 18.

Laboratoire de Parasitologie-Mycologie, CHU Aristide Le Dantec, BP 5005, Dakar, Senegal.

Classically, dermatophytes are identified by phenotypic methods even if these methods, sometimes, remain difficult or uncertain. On the other hand, nucleotide sequence analysis of internal transcribed spacers (ITS) of rDNA has proved to be a useful method for identification of dermatophytes. The objective of this study was to compare the phenotypic method with DNA sequencing of the ITS regions for identification of dermatophyte species isolated in Dakar, Senegal. Read More

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http://dx.doi.org/10.1155/2019/6754058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942864PMC
December 2019

Madurella mycetomatis infection of the foot: a case report of a neglected tropical disease in a non-endemic region.

BMC Dermatol 2020 01 10;20(1). Epub 2020 Jan 10.

Dermatology and Venereology Department, Ibn Sina Hospital, Mohammed V University, Rabat, Morocco.

Background: Mycetoma is an uncommon chronic granulomatous infection of cutaneous and subcutaneous tissues that can be caused by filamentous bacteria (actinomycetoma) or fungi (eumycetoma). It is the prerogative of young men between the third and fourth decade and is transmitted through any trauma causing an inoculating point. The classic clinical triad associates a painless hard and swelling subcutaneous mass, multiple fistulas, and the pathognomonic discharge of grains. Read More

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http://dx.doi.org/10.1186/s12895-019-0097-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953183PMC
January 2020

Madurella mycetomatis, the main causative agent of eumycetoma, is highly susceptible to olorofim.

J Antimicrob Chemother 2020 Apr;75(4):936-941

Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Centre, Rotterdam, The Netherlands.

Objectives: Eumycetoma is currently treated with a combination of itraconazole therapy and surgery, with limited success. Recently, olorofim, the lead candidate of the orotomides, a novel class of antifungal agents, entered a Phase II trial for the treatment of invasive fungal infections. Here we determined the activity of olorofim against Madurella mycetomatis, the main causative agent of eumycetoma. Read More

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http://dx.doi.org/10.1093/jac/dkz529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069493PMC

Eumycetoma diagnosed in urban Australia.

Med J Aust 2020 02 24;212(3):107-107.e1. Epub 2019 Dec 24.

Peninsula Health, Melbourne, VIC.

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http://dx.doi.org/10.5694/mja2.50464DOI Listing
February 2020

Unusual extra-podal fungal mycetoma with black grains in a Senegalese child.

J Mycol Med 2020 Apr 9;30(1):100914. Epub 2019 Dec 9.

Department of Dermatology, Hospital Institute of Social Hygiene (IHS), BP: 7045, Dakar, Senegal.

Mycetoma remains endemic in the tropical and subtropical regions of the "mycetoma belt" including Senegal. It affects more commonly young men in the age group of 20 to 40 years. The foot represents the most commonly affected site. Read More

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http://dx.doi.org/10.1016/j.mycmed.2019.100914DOI Listing

[Plantar actinomycetoma in a patient without risk factors].

Rev Chilena Infectol 2019 Aug;36(4):531-535

Pontificia Universidad Católica de Chile, Santiago, Chile.

A case of plantar actinomycetoma without risk factors is presented, which was diagnosed by hystopatological analysis of a foot biopsy because of the suspicion of neoplasia. Since the patient did not fully respond to the first-line therapy antibiotics, a 24-weeks doxycycline regime was started, achieving a satisfactory response. Finally, a brief discussion on plantar mycetomas is presented. Read More

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http://dx.doi.org/10.4067/S0716-10182019000400531DOI Listing

Bridging the knowledge gap on mycoses in Africa: Setting up a Pan-African Mycology Working Group.

Mycoses 2020 Mar 30;63(3):244-249. Epub 2019 Dec 30.

Department of Medical Microbiology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.

Most African countries have poorly funded and overburdened health systems. Additionally, a high prevalence of HIV in Sub-Saharan Africa contributes to a high burden of opportunistic fungal infections. Data generated by GAFFI from 15 of 57 African countries revealed that an estimated 47 million Africans suffer from fungal diseases, of whom an estimated 1. Read More

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http://dx.doi.org/10.1111/myc.13044DOI Listing

[Pulmonary Metastase of a Knee Mycetoma in Senegal].

Bull Soc Pathol Exot 2019 ;112(3):129-132

Service d'orthopédie-traumatologie, hôpital général de Grand Yoff, Dakar, Sénégal.

Mycetoma is transmitted by thorns infected. The commonest site for mycetoma is the foot. The primary pulmonary are rare and usually secondary to other primary site. Read More

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http://dx.doi.org/10.3166/bspe-2019-0091DOI Listing

Geographical distribution of mycetoma cases in senegal over a period of 18 years.

Mycoses 2020 Mar 14;63(3):250-256. Epub 2020 Jan 14.

Cheikh Anta Diop University of Dakar, Dakar, Senegal.

Background: Mycetoma is a pathological process in which fungal or actinomycotic agents of exogenous origin produce grains. In the absence of data on the global burden, it is important to map mycetoma cases, which are useful to implement control strategies.

Objective: The objective of this study was to map mycetoma cases diagnosed in Senegal over a period of eighteen years. Read More

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http://dx.doi.org/10.1111/myc.13037DOI Listing

Endobronchial aspergilloma-a comprehensive literature review with focus on diagnosis and treatment modalities.

Eur J Clin Microbiol Infect Dis 2020 Apr 18;39(4):601-605. Epub 2019 Nov 18.

Staten Island University Hospital, 70 Hancock Street, Unit 1C, Staten Island, NY, 10305, USA.

Endobronchial aspergilloma (EBA) is a rare manifestation of pulmonary infection with Aspergillus spp. Comprised of hyphae, mucus, and cellular debris, the massive fungus overgrowth can lead to obstructive pneumonitis in large airways, manifesting as cough, dyspnea, hemoptysis, or weight loss. The aim of this paper is to review the literature on endobronchial aspergilloma to further elucidate this disease entity and to classify it as a non-invasive form of pulmonary aspergillosis. Read More

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http://dx.doi.org/10.1007/s10096-019-03726-5DOI Listing
April 2020
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