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J Eur Acad Dermatol Venereol 2022 Jun 24. Epub 2022 Jun 24.

The Mycetoma Research Center, University of Khartoum, Khartoum, Sudan.

Background: Ultrasound (US)-guided fine-needle aspiration cytology (US-FNAC) has improved the diagnosis of many malignancies, infections, and other diseases as it is safe, simple, quick and accurate. In mycetoma, it is assumed that this technique may have a better diagnostic yield than the conventional FNAC as it can accurately identify the optimal site for the aspiration.

Objective: to compare the diagnostic yield of conventional FNAC with US-FNAC. Read More

Infez Med 2022 1;30(2):285-292. Epub 2022 Jun 1.

Clinical Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy.

is a genus of aerobic actinomycetes that are usually responsible for opportunistic infection in immunocompromised patients. Less frequently nocardiosis can interest immunocompetent population, causing especially primary cutaneous infections. Cutaneous involvement by spp. Read More

Med Trop Sante Int 2021 12 10;1(4). Epub 2021 Nov 10.

Service d'orthopédie-traumatologie, Centre National Hospitalier Universitaire Hubert Koutougou MAGA de Cotonou (CNHU-HKM), Bénin.

Objective: The objective of this study was to describe the epidemiological and clinical aspects as well as the therapeutic methods of mycetomical lesions.

Material And Methods: This was a longitudinal retrospective study, which included all patients treated for mycetoma from January 2016 to December 2018 including two years of recruitment and one year of monitoring (2019). The study concerned 19 patients who were hospitalized and treated in the department of surgery. Read More

Med Trop Sante Int 2022 03 11;2(1). Epub 2022 Feb 11.

Service de dermatologie, Centre hospitalier universitaire Aristide Le Dantec, Dakar, Sénégal.

Objectives: Although the foot remains the main localization of mycetomas, extrapodal attacks, which are rarely studied, are also possible and occur either initially or following an extension. The objectives were to describe the epidemiological, clinical and etiological features of extrapodal mycetomas in Senegal.

Methodology: Cross-sectional and retrospective study with multicentric enrollment in four reference department, two of which are in dermatology and two in orthopedics and traumatology. Read More

Disaster Med Public Health Prep 2022 Jun 8:1-12. Epub 2022 Jun 8.

Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.

Globally, tuberculosis (TB) is one of the leading infectious causes of mortality, with around 4000 deaths daily. Since the emergence of the coronavirus disease 2019 (COVID-19) pandemic in Africa, the region has experienced a lapse in responses directed at TB control, since the priority has shifted to interventions aimed at managing COVID-19. In addition to an unprecedented burden on the region's already overburdened health systems, another major public health concern is the clinical similarities between COVID-19 and TB, making TB diagnosis increasingly challenging, which may lead to poor prognosis especially in people with TB and COVID-19 co-infection. Read More

Trans R Soc Trop Med Hyg 2022 May 30. Epub 2022 May 30.

Mycetoma Research Center, Soba University Hospital, University of Khartoum, Sudan.

Expert Opin Drug Discov 2022 Jun 9:1-19. Epub 2022 Jun 9.

Department of Microbiology and Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Introduction: The three fungal skin neglected tropical diseases (NTD) - mycetoma, chromoblastomycosis and sporotrichosis - currently lack prioritization and support to establish drug discovery programs in search for novel treatment options. This has made the efforts to identify novel drugs for these fragmented skinNTDs.

Areas Covered: To help escalate the discovery of novel drugs to treat these fungal skinNTDs, the authors have prepared an overview of the compounds with activity against fungal skinNTDs by analyzing data from individual drug discovery studies, including those performed on the Medicines for Malaria Venture (MMV) open access boxes. Read More

Trans R Soc Trop Med Hyg 2022 May 10. Epub 2022 May 10.

Mycetoma Research Centre, University of Khartoum, Khartoum, Sudan.

A cholera outbreak in Blue Nile and Sennar states, south-eastern and southern Sudan, took place during September-December 2019. An outbreak surveillance sample collection was made. Vibrio cholerae O1 Ogawa was isolated from clinical samples of all confirmed 200 and 132 cases in Blue Nile state and Sennar state, respectively. Read More

Brain Behav 2022 May 21;12(5):e2577. Epub 2022 Apr 21.

Department of Research and Education, Oli Health Magazine Organization, Kigali, Rwanda.

Introduction: Parkinson's disease is one of the progressive neurodegenerative diseases from which people suffer for years. The mechanism of this disease is associated with a decrease in the number of dopaminergic neurons in the substantia nigra (SN) while Lewy bodies are still present. As a result, both motor-ridity, tremor, and bradykinesia-and non-motor symptoms such as anxiety and depression. Read More

J Fungi (Basel) 2022 Apr 17;8(4). Epub 2022 Apr 17.

Global Action for Fungal Infections, 1208 Geneva, Switzerland.

Few data are published from Morocco on fungal disease, although numerous case reports attest to a wide range of conditions in the country. Here, we estimate for the first time the incidence and prevalence of serious fungal diseases in the country. Detailed literature searches in English and French were conducted for all serious fungal infections. Read More

Mycopathologia 2022 Jun 20;187(2-3):189-197. Epub 2022 Apr 20.

Department of Dermatology, Hangzhou Third People's Hospital, Affiliated Hangzhou Dermatology Hospital, Zhejiang University School of Medicine, West Lake Rd 38, Hangzhou, 310009, China.

Deep cutaneous fungal infections including deep dermatophytosis are responsible for significant morbidity and mortality, especially in immunocompromised patients. Variable and longer turnaround time on tissue culture results delay diagnosis. We sought to seek the fast bedside diagnosis for disseminated deep dermatophytosis by direct microscopy using a blunt scalpel or needle aspiration before biopsy. Read More

Malar J 2022 Apr 15;21(1):124. Epub 2022 Apr 15.

Molecular Biology Unit, Sirius Training and Research Centre, Khartoum, Sudan.

Background: Malaria is a life-threatening public health problem globally with particularly heavy burden in the sub-Saharan Africa including Sudan. The understanding of feeding preference of malaria vectors on different hosts is a major challenge for hindering the transmission cycle of malaria. In this study, blood meals taken by blood-fed Anopheles mosquitoes collected from the field in malaria endemic areas of Sudan were analysed for source of blood meal and malaria parasite presence. Read More

J Orthop Case Rep 2021 Dec;11(12):44-46

Department of Orthopaedics, DR. S. N Medical College, Jodhpur, India.

Introduction: It is a form of chronic granulomatous infection involving skin, subcutaneous tissue, and skeletal system. The authors report a case of mycetoma presenting as knee swelling.

Case Report: A 25-year-old male presented to outdoor with painless swelling around medial aspect of the right knee joint with intermittent discharge of black granules from sinus since 6 months. Read More

Mycoses 2022 Jun 6;65(6):650-655. Epub 2022 May 6.

Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.

Introduction: Eumycetoma is a subcutaneous mutilating disease that can be caused by many different fungi. Current treatment consists of prolonged itraconazole administration in combination with surgery. In many centres, due to their slow growth rate, the treatment for eumycetoma is often started before the causative agent is identified. Read More

Indian J Dermatol Venereol Leprol 2022 Mar 11:1-8. Epub 2022 Mar 11.

Department of General Surgery, Saudi Hospital, Hajjah, Yemen.

Background: Mycetoma is widespread in Yemen; however, there are only a few documented reports on the entity from this geographical area.

Methods: A prospective study of 184 cases of mycetoma (male 145 and female 39) from different regions of north-western Yemen was conducted between July 2000 and May 2014. Clinical profile was recorded in a standardized protocol. Read More

Radiol Case Rep 2022 May 29;17(5):1817-1823. Epub 2022 Mar 29.

Anatomopathology Service, Ibn Rochd University Hospital, Faculty of Medicine and Pharmacy of Casablanca, Casablanca, 20100, Morocco.

Mycetomas caused by aerobic actinomycetes are called actinomycetomas. It is primarily localized in subcutaneous tissue but it can spread to different tissue planes including the skin, deep tissues and structures and eventually the bones. We report the cases of 2 patients referred for evaluation of soft tissue masses involving the foot. Read More

Med J Armed Forces India 2022 Mar 28. Epub 2022 Mar 28.

Associate Professor, Department of Oral Maxillo Facial Surgery, Armed Forces Medical College, Pune, India.

COVID-19 (Coronavirus Disease 2019), illness with associated comorbidities and corticosteroid therapy makes the host immunocompromised and prone to opportunistic microbial infections As the world continues to struggle with the pandemic of COVID-19, an increase in cases of opportunistic fungal infections have been reported from all over the world during the second wave of COVID-19 like aspergillosis, mucormycosis, and candidiasis. is an emerging pathogen that is usually associated with mycetoma, pulmonary infection, and central nervous infections. It has been rarely associated with fungal rhinosinusitis (FRS). Read More

J Investig Med High Impact Case Rep 2022 Jan-Dec;10:23247096221084852

UCLA-Kern Medical, Bakersfield, CA, USA.

Coccidioidomycosis (CM) is a fungal disease that results from inhalation of spores of and . If symptomatic, disease primarily manifests as community-acquired pneumonia; however, additional pulmonary manifestations such as pleural effusion, empyema, and cavitation may occur. Diabetic patients have an increased risk of severe and cavitary CM. Read More

J Am Podiatr Med Assoc 2021 Dec 15;111(6). Epub 2021 Dec 15.

Eumycetoma, caused by fungi, is a neglected tropical disease. It is endemic in the "mycetoma belt" countries but rare in North America. We report a case of pedal eumycetoma in the state of Maryland. Read More

PLoS Negl Trop Dis 2022 03 11;16(3):e0010274. Epub 2022 Mar 11.

School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan.

Mycetoma is a tropical disease caused by several fungi and bacteria present in the soil. Fungal mycetoma and eumycetoma are especially challenging to treat; therefore, prevention, early diagnosis, and early treatment are important, but it is also necessary to understand the geographic distribution of these pathogenic fungi. In this study, we used DNA metabarcoding methodology to identify fungal species from soil samples. Read More

Clin Exp Dermatol 2022 Mar 10. Epub 2022 Mar 10.

Department of Mycology, Hospital General de México Dr Eduardo Liceaga, Mexico City, Mexico.

An illustrative case of mini-mycetoma in a 54-year-old female agricultural worker from Mexico. Read More

Med Mycol 2022 Apr;60(4)

Molecular Mycology Research Laboratory, Centre for Infectious Diseases and Microbiology, Faculty of Medicine and Health, Sydney Medical School, Westmead Clinical School, The University of Sydney, Westmead, NSW 2145, Australia.

Scedosporium species are emerging opportunistic fungal pathogens causing various infections mainly in immunocompromised patients, but also in immunocompetent individuals, following traumatic injuries. Clinical manifestations range from local infections, such as subcutaneous mycetoma or bone and joint infections, to pulmonary colonization and severe disseminated diseases. They are commonly found in soil and other environmental sources. Read More

Int J Surg Case Rep 2022 Mar 25;92:106868. Epub 2022 Feb 25.

Hajj Almardy Teaching Hospital, Sudan University of Science and Technology, Khartoum, Sudan.

Introduction: Mycetoma is a neglected tropical disease that commonly affects the lower extremity. The disease is attributed to subcutaneous granulomatous inflammation leading to distinct clinical features of gradual painless swelling accompanied by nodules and drains. Orbital mycetoma is an extremely rare entity of the disease. Read More

Med Mycol Case Rep 2022 Mar 1;35:51-53. Epub 2022 Feb 1.

Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Padua, 35020, Italy.

Canine eumycetoma is a rare granulomatous disease caused by dematiaceous fungi. A 2-year-old Great Dane dog had a subcutaneous mass in the right thigh that was surgically removed. Grossly, numerous black-grains were visible. Read More

Immun Inflamm Dis 2022 03 10;10(3):e591. Epub 2022 Feb 10.

Oli Health Magazine Organization, Research, and Education, Kigali, Rwanda.

Introduction: Human Immunodeficiency virus (HIV) is a virus that causes several diseases by attacking the human immune system. It is transmitted by contact with certain bodily fluids of an infected person, most commonly during unprotected sex, through sharing needles, or from mother to baby during pregnancy, birth or breastfeeding. The central nervous system is not spared from this virus, as HIV has been shown to induce several neurological disorders. Read More

PLoS Negl Trop Dis 2022 02 4;16(2):e0010159. Epub 2022 Feb 4.

Erasmus MC, University Medical Center Rotterdam, Department of Microbiology and Infectious Diseases, Rotterdam, The Netherlands.

Eumycetoma is a chronic subcutaneous neglected tropical disease that can be caused by more than 40 different fungal causative agents. The most common causative agents produce black grains and belong to the fungal orders Sordariales and Pleosporales. The current antifungal agents used to treat eumycetoma are itraconazole or terbinafine, however, their cure rates are low. Read More

Ear Nose Throat J 2022 Jan 27:1455613221074957. Epub 2022 Jan 27.

Department of Otorhinolaryngology, 13707National Hospital Organization Osaka National Hospital, Chu-ouku, Osaka City, Osaka, Japan.

Objectives: Chronic rhinosinusitis (CRS) is a common disease with mucosal inflammation, and may sometimes be accompanied by bone thickening. The disease is usually bilateral; when it is unilateral, there may be a specific disease. This study aimed to investigate the association between unilateral sinus opacification and osteitis. Read More

Med Mycol 2022 Feb;60(2)

Erasmus MC, University Medical Center Rotterdam, Department of Medical Microbiology and Infectious Diseases, Rotterdam, the Netherlands.

Eumycetoma is a neglected tropical disease, and Madurella mycetomatis, the most common causative agent of this disease forms black grains in hosts. Melanin was discovered to be one of the constituents in grains. Melanins are hydrophobic, macromolecular pigments formed by oxidative polymerisation of phenolic or indolic compounds. Read More

Clin Exp Dermatol 2022 Jun 17;47(6):1180-1181. Epub 2022 Feb 17.

Dermatology Department, Hospital Universitario Dr Jose Eleuterio Gonzalez, Universidad Autónoma de Nuevo León, Nuevo León, Mexico.

Dermoscopy of mycetoma has white structures as the predominant feature, while white scale and yellowish structures were also consistent in our findings with available literature. Read More

J Glob Infect Dis 2021 Oct-Dec;13(4):192-195. Epub 2021 Nov 23.

Department of Pathology, ICMR National Institute of Pathology, VMMC and Safdarjung Hospital, New Delhi, India.

Mycetoma is a chronic granulomatous infection caused by fungi or bacteria, known as eumycetoma and actinomycetoma, respectively. Mycetoma commonly affects young males belonging to low socioeconomic strata, usually barefooted agricultural workers. It mainly affects lower and upper limbs presenting as a painless swelling with discharging sinus. Read More