Obstet Gynecol 2022 04 10;139(4):529-535. Epub 2022 Mar 10.
Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden; Mercy Perinatal, Mercy Hospital for Women, Melbourne, Australia; the Translational Obstetrics Group, Department of Obstetrics and Gynaecology, University of Melbourne, Heidelberg, Australia; the Department of Obstetrics and Gynaecology, Stellenbosch University, Cape Town, South Africa; the Centre for Clinical Research, Dalarna, Sweden; and the Department of Obstetrics and Gynecology, Institute of Clinical Science, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Objective: To estimate whether low-dose aspirin use is associated with an altered risk of delivering a small-for-gestational age (SGA) neonate among women with a history of having an SGA neonate in a prior pregnancy.
Methods: We performed a Swedish register-based cohort study including women in their second pregnancy who had a history of having an SGA neonate (birth weight less than the 10th percentile). The association between use of low-dose aspirin in subsequent pregnancy and birth of an SGA neonate or a severely SGA neonate (birth weight less than the third percentile) were estimated using inverse propensity-weighted estimation, accounting for potential confounders. Read More