3,305 results match your criteria Essentials of Tissue Movement


[CARs, CRS and neurotoxicity: severe complications after administration of immunotherapy : Essentials for intensivists].

Med Klin Intensivmed Notfmed 2018 Dec 13. Epub 2018 Dec 13.

Klinik I für Innere Medizin, Uniklinik Köln, Kerpener Str. 62, 50937, Köln, Deutschland.

Background: The development of chimeric antigen receptor (CAR) T‑cells has shown promising results in relapsed/refractory B‑cell acute lymphoblastic leukemia/lymphoma (B-ALL) and diffuse large cell B‑cell lymphoma. Complications, especially cytokine release syndrome (CRS) and CAR T‑cell related encephalopathy syndrome (CRES), can be life threatening. The management of both plays a key role in CAR T‑cell therapy. Read More

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December 2018

Consumption displacement in households with noncommunicable diseases in Bangladesh.

PLoS One 2018 13;13(12):e0208504. Epub 2018 Dec 13.

Global Noncommunicable Diseases Branch, Division of Global Health Protection, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA, United States of America.

The economic burden of noncommunicable diseases (NCDs), including treatment costs and income and productivity losses, is a growing concern in developing countries, where NCD medical expenditure may offset consumption of other essential commodities. This study examines the role of NCDs in household resource allocation in Bangladesh. We use the Bangladesh Household Income and Expenditure Survey (HIES) 2010 to obtain expenditure data on 11 household expenditure categories and 12 food expenditure sub-categories for 12,240 households. Read More

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December 2018

The Essentials-Only Emergency Tracheotomy Pan: Keeping It Simple With Open Emergent Airways.

JAMA Otolaryngol Head Neck Surg 2018 Dec 13. Epub 2018 Dec 13.

Division of Otolaryngology-Head & Neck Surgery, The University of Wisconsin School of Public Health and Medicine, Madison.

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December 2018

Financial Distress and Smoking-induced Deprivation in Smokers with Depression.

Authors:
Erin S Rogers

Am J Health Behav 2019 Jan;43(1):219-227

NYU School of Medicine, Department of Population Health, New York, NY;, Email:

Tobacco use may be related to financial strain in people with depression. This study explored the relationship among tobacco expenditures, financial distress, and smoking-induced deprivation (SID) in smokers with and without depression. Adult tobacco users in the United States (N = 234) completed a survey assessing depression (PHQ-8≥10), sociodemographics, tobacco use and spending, financial satisfaction and distress, and SID. Read More

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January 2019

[Design of points, lines and planes in the reconstruction of occlusion and the risk control in implantation].

Authors:
J Chen

Zhonghua Kou Qiang Yi Xue Za Zhi 2018 Dec;53(12):805-809

Department of Dental Implantology, Affiliated Stomatological Hospital, Fujian Medical University, Fuzhou 350002, China.

Occlusion reconstruction involves various factors, such as joints, muscles, teeth and mental states. The relationship between implantation complications and occlusion, especially in the method of reducing the risk of implantation during occlusal reconstruction, is more and more emphasized by clinicians. This article mainly summarized the essentials of occlusal factors, such as mandibular position, cusp inclination and occlusal contacts, Spee's curve, Wilson curve and occlusal plane, in clinical treatment from the perspective of static geometry, dynamic functional movement in points, lines and planes, in order to accomplish precise occlusion reconstruction to achieve a stable and functional occlusion reconstruction, i. Read More

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December 2018

Biosafety and Biohazards: Understanding Biosafety Levels and Meeting Safety Requirements of a Biobank.

Methods Mol Biol 2019 ;1897:213-225

Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

When it comes to biobanking and working with different types of laboratory specimens, it is important to understand potential biohazards to ensure safety of the operator and laboratory personnel. Biological safety levels (BSL) are a series of designations used to inform laboratory personnel about the level of biohazardous risks in a laboratory setting. There are a total of four levels ranked in order of increasing risk as stipulated by the Center of Disease Control and Prevention (CDC) (Biosafety in microbiological and biomedical laboratories, 5th edn. Read More

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January 2019

Essentials of extracellular vesicles: posters on basic and clinical aspects of extracellular vesicles.

J Extracell Vesicles 2018 30;7(1):1548234. Epub 2018 Nov 30.

Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary.

The past decade has witnessed an exponential development in the field of extracellular vesicles. Sporadic observations have reached a critical level and the scientific community increasingly recognizes the potential biomedical significance of these subcellular structures present in all body fluids as significant components of the cellular secretome. The Educational Committee of the International Society for Extracellular Vesicles prepared two posters ("Basic aspects of extracellular vesicles" and "Clinical aspects of extracellular vesicles") to provide essential pieces of information on extracellular vesicles at glance for anyone not familiar with the field. Read More

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November 2018

Essentials of Spine Trauma Imaging: Radiographs, CT, and MRI.

Semin Ultrasound CT MR 2018 Dec 26;39(6):532-550. Epub 2018 Oct 26.

Division of Neuroradiology, Department of Radiology, Michigan Medicine, Ann Arbor, MI. Electronic address:

Traumatic injuries of the spine portend long-term morbidity and mortality. Timely diagnosis and appropriate management of mechanical instability of the spine is of utmost importance in preventing further neurologic deterioration. We present a comprehensive review of the indications for spinal imaging in the trauma setting, describe each imaging modality including plain radiographs, multidetector computed tomography and magnetic resonance imaging, basic anatomy and common fracture patterns, and discuss the traditional spinal injury classification systems and the new Subaxial Cervical Spine Injury Classification and Thoracolumbar Injury Classification and Severity score. Read More

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December 2018

Cellular and molecular mechanisms of sarcopenia: the S100B perspective.

J Cachexia Sarcopenia Muscle 2018 Nov 30. Epub 2018 Nov 30.

Department of Experimental Medicine, University of Perugia, Perugia, 06132, Italy.

Primary sarcopenia is a condition of reduced skeletal muscle mass and strength, reduced agility, and increased fatigability and risk of bone fractures characteristic of aged, otherwise healthy people. The pathogenesis of primary sarcopenia is not completely understood. Herein, we review the essentials of the cellular and molecular mechanisms of skeletal mass maintenance; the alterations of myofiber metabolism and deranged properties of muscle satellite cells (the adult stem cells of skeletal muscles) that underpin the pathophysiology of primary sarcopenia; the role of the Ca -sensor protein, S100B, as an intracellular factor and an extracellular signal regulating cell functions; and the functional role of S100B in muscle tissue. Read More

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November 2018
2 Reads

Trust the Process: A New Scientific Outlook on Psychodramatic Spontaneity Training.

Authors:
Dani Yaniv

Front Psychol 2018 14;9:2083. Epub 2018 Nov 14.

Emili Sagol Creative Arts Therapies Research Center, The Graduate School of Creative Arts Therapies, University of Haifa, Haifa, Israel.

Human mind is hypothesis-driven and our observations of the world are strongly shaped by preconceptions. This "top-down" principle is biologically driven and contraindicative to spontaneity, which is non-linear, condensed, and initially incomprehensible. My first argument is that spontaneity entails "bottom up" information processing, as articulated in the hierarchical neurocognitive model of perception. Read More

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November 2018

Paring down to the essentials.

Authors:
Tim Wang

Science 2018 11;362(6417):904

Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.

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November 2018

The Role of the Pelvic Floor in Respiration: A Multidisciplinary Literature Review.

J Voice 2018 Nov 14. Epub 2018 Nov 14.

Hofstra University, Long Island, New York. Electronic address:

Objective: To conduct an interdisciplinary literature review on the function of the pelvic floor musculature during respiration and its role in phonation, particularly singing.

Study Design: This is a literature review.

Methods: A literature review was conducted using three electronic databases: PubMed, Scopus, and Google Scholar. Read More

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November 2018
1 Read

Emicizumab, the bispecific antibody to factors IX/IXa and X/Xa, potentiates coagulation function in factor XI-deficient plasma in vitro.

J Thromb Haemost 2018 Nov 16. Epub 2018 Nov 16.

Department of Pediatrics, Nara Medical University, Kashihara, Nara, Japan.

Essentials Emicizumab mimics factor (F)VIIIa cofactor function, augments the intrinsic tenase activity. We assessed the emicizumab-driven hemostatic function in FXI-deficient plasmas. Emicizumab improved the coagulation potentials in severe FXI-deficient plasma. Read More

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November 2018
6 Reads

The antifibrinolytic and anti-inflammatory effects of multiple doses of oral tranexamic acid in total knee arthroplasty patients: a randomized controlled trial.

J Thromb Haemost 2018 Dec 15;16(12):2442-2453. Epub 2018 Nov 15.

Center for Joint Surgery, Southwest Hospital, Third Military Medical University, Chengdu, China.

Essentials Perioperative blood loss and inflammatory response can significantly affect recovery after surgery. We studied the effects of multiple-dose oral tranexamic acid on blood loss and inflammatory response. A postoperative four-dose regimen brought about maximum reduction in postoperative blood loss. Read More

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December 2018
5 Reads

A Retrospective Study on Bovine Tuberculosis in Cattle on Fiji: Study Findings and Stakeholder Responses.

Front Vet Sci 2018 26;5:270. Epub 2018 Oct 26.

The University of Sydney, Farm Animal Health, Sydney School of Veterinary Science, Sydney, NSW, Australia.

Bovine tuberculosis (bTB) is globally significant due to its impacts on cattle production. A Brucellosis and Tuberculosis Eradication and Control (BTEC) program commenced in Fiji during the 1980's and has since been sustained by government funding and industry cooperation. A retrospective study of bTB data obtained during the Fiji BTEC program from 1999 to 2014 was undertaken at the University of Sydney with support from the Government of Fiji. Read More

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October 2018
5 Reads

Chronic liver injury drives non-traditional intrahepatic fibrin(ogen) crosslinking via tissue transglutaminase.

J Thromb Haemost 2018 Nov 11. Epub 2018 Nov 11.

Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, USA.

Essentials Fibrin clots are often implicated in the progression of liver fibrosis. Liver fibrosis was induced in transgenic mice with defects in clot formation or stabilization. Liver fibrosis and fibrin(ogen) deposition do not require fibrin polymerization or factor XIIIa. Read More

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November 2018
4 Reads

Essentials of Physiotherapy after Thoracic Surgery: What Physiotherapists Need to Know. A Narrative Review.

Korean J Thorac Cardiovasc Surg 2018 Oct 5;51(5):293-307. Epub 2018 Oct 5.

Department of Physical Therapy for Cardiovascular and Respiratory Disorders, Faculty of Physical Therapy, Cairo University.

Physiotherapy has recently become an essential part of enhanced recovery protocols after thoracic surgery. The evidence-based practice of physiotherapy is essential for the effective management of postoperative patients. Unfortunately, only a small body of literature has discussed the rationale of the physiotherapy interventions that are routinely implemented following thoracic surgery. Read More

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October 2018

Factor XII truncation accelerates activation in solution.

J Thromb Haemost 2018 Nov 5. Epub 2018 Nov 5.

Department of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.

Essentials During contact system activation, factor XII is progressively cleaved by plasma kallikrein. We investigated the role of factor XII truncation in biochemical studies. Factor XII contains naturally occurring truncating cleavage sites for a variety of enzymes. Read More

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November 2018
5 Reads

Population pharmacokinetics of factor IX in hemophilia B patients undergoing surgery.

J Thromb Haemost 2018 Nov 28;16(11):2196-2207. Epub 2018 Oct 28.

Hospital Pharmacy-Clinical Pharmacology, Academic Medical Center Amsterdam, Amsterdam, the Netherlands.

Essentials Factor IX (FIX) dosing using body weight frequently results in under and overdosing during surgery. We aimed to establish a population pharmacokinetic (PK) model describing the perioperative FIX levels. Population PK parameter values for clearance and V1 were 284 mL h70 kg and 5450 mL70 kg. Read More

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November 2018
4 Reads

The evaluation of inflammatory, anti-inflammatory and regulatory factors contributing to the pathogenesis of COPD in airways.

Pathol Res Pract 2018 Oct 29. Epub 2018 Oct 29.

Department of Morphology, Institute of Anatomy and Anthropology, Riga Stradins University, Riga, LV-1010, Latvia.

Introduction: Chronic obstructive pulmonary disease (COPD) is a progressive chronic disease leading to obstructive lung airways and airflow limitations. The background of COPD is extensive cytopathology and histopathology orchestrated by mostly chronic inflammation with the local release of inflammatory, anti-inflammatory and regulatory mediators, as well as further remodeling and shaping of local architecture. Inflammatory mechanisms are provided by complex intercellular signalling networks and regulation of locally occurring immune responses. Read More

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October 2018
3 Reads

Essentials on Oncological Imaging: Postoperative Computed Tomography and Magnetic Resonance Imaging of Oral Tongue Cancer.

Can Assoc Radiol J 2018 Nov;69(4):458-467

Department of Radiology, Ichikawa General Hospital Tokyo Dental College, Sugano, Ichikawa-shi, Chiba, Japan.

The contribution of diagnostic imaging in evaluating the pre- and postoperative status of tongue cancer is essential. Interpretation of postoperative images is made difficult by deformation; therefore, it is necessary to know how surgical technique, biological reaction, postoperative anatomy, and local recurrence are reflected on the images. This study explains the postoperative imaging features of tongue cancer to help in the early detection of local recurrence and avoid inappropriate treatment. Read More

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November 2018
3 Reads

A unique phenotype of acquired Glanzmann thrombasthenia due to non-function-blocking anti-αIIbβ3 autoantibodies.

J Thromb Haemost 2018 Nov 2. Epub 2018 Nov 2.

Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Suita, Japan.

Essentials Acquired Glanzmann thrombasthenia (aGT) is generally caused by function-blocking antibodies (Abs). We demonstrated a unique aGT case due to marked reduction of αIIbβ3 with anti-αIIbβ3 Abs. The anti-αIIbβ3 Abs of the patient did not inhibit platelet function but reduced surface αIIbβ3. Read More

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November 2018
3 Reads

Use of Emotional Intelligence to Enhance Advanced Practice Registered Nursing Competencies.

Authors:
Kathleen M Cox

J Nurs Educ 2018 Nov;57(11):648-654

Background: Interpersonal relationships are fundamental to competent delivery of health care. Nursing practice is grounded in interpersonal relationships, making advanced practice registered nurses (APRNs) well prepared to ensure the delivery of safe, effective care. Research demonstrates interpersonal dynamics can be enhanced. Read More

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November 2018
11 Reads

[Pay special attentions to the essentials in conducting surgical trials].

Authors:
Y Xiao

Zhonghua Wai Ke Za Zhi 2018 Oct;56(10):737-740

Department of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

Conducting clinical trials is a distinguishing responsibility for surgeons, which could provide high quality evidence to guidelines for clinical practice and healthcare policy. However, implementation of clinical researches or trials is the weakness for general surgeons for quite some time. Finding scientific problems, determining study type, selecting rational endpoints, calculating sample size, defining proper observation index, strictly control of the research process and correctly evaluating the final sets are important steps for investigators. Read More

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October 2018

Blending Gagne's Instructional Model with Peyton's Approach to Design an Introductory Bioinformatics Lesson Plan for Medical Students: Proof-of-Concept Study.

JMIR Med Educ 2018 Oct 25;4(2):e11122. Epub 2018 Oct 25.

Department of Basic Medical Sciences, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates.

Background: With the rapid integration of genetics into medicine, it has become evident that practicing physicians as well as medical students and clinical researchers need to be updated on the fundamentals of bioinformatics. To achieve this, the following gaps need to be addressed: a lack of defined learning objectives for "Bioinformatics for Medical Practitioner" courses, an absence of a structured lesson plan to disseminate the learning objectives, and no defined step-by-step strategy to teach the essentials of bioinformatics in the medical curriculum.

Objective: The objective of this study was to address these gaps to design a streamlined pedagogical strategy for teaching basics of bioinformatics in the undergraduate medical curriculum. Read More

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October 2018
3 Reads

Early Caffeine: Essentials for the Neonatal Nurse.

Authors:
Sara E Rostas

J Perinat Neonatal Nurs 2018 Oct/Dec;32(4):300-302

Clinical Pharmacy Specialist, Neonatal ICU Department of Pediatric Newborn Medicine Brigham and Women's Hospital Boston, Massachusetts.

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October 2018

[Feasibility and Technical Essentials of Developing MRI Helium-free Superconducting Magnets].

Authors:
Huixian Yu

Zhongguo Yi Liao Qi Xie Za Zhi 2018 Sep;42(5):345-349

Mednova Medical Technologies Co. Ltd, Hangzhou, 310053.

In this paper, from the current situation of the domestic use of superconducting MRI, on liquid helium supply and demand crisis in the market, according to the production process of the enterprise, taking the medical 1.5 T superconducting magnet as an example, the main design essentials of the helium-free magnet are introduced comprehensively, the feasibility of the helium-free magnet research and development are described, important value orientation for the domestic manufacture and use of superconducting MRI was provided. Read More

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September 2018
6 Reads

Clinically relevant differences between assays for von Willebrand factor activity.

J Thromb Haemost 2018 Dec 20;16(12):2413-2424. Epub 2018 Nov 20.

Hematology, Erasmus University Medical Center, Rotterdam, the Netherlands.

Essentials It is unclear whether there are differences between von Willebrand factor (VWF) activity assays. We compared the four most used VWF activity assays in 661 von Willebrand disease (VWD) patients. All assays correlated excellently, but a discrepant classification was seen in 20% of patients. Read More

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December 2018
5 Reads

Effects of a Novel Formulation on Oral Biofilm, pH Buffering, and Gingival Health in Patients with Dry Mouth.

Int J Dent 2018 23;2018:2748274. Epub 2018 Sep 23.

Beckman Laser Institute, University of California, Irvine, CA 92612, USA.

Goal: To identify in patients with dry mouth the effects of a novel test agent (Oral Essentials Hydrating Formula Mouthwash, Beverly Hills, CA) versus a control agent (Biotène Dry Mouth Oral Rinse, GlaxoSmithKline Consumer Healthcare L.P., Moon Township, PA, USA) versus no treatment on dry mouth, plaque, salivary pH and buffering capacity, gingival health, and tooth sensitivity. Read More

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September 2018

Evaluation of unfractionated heparin versus low-molecular-weight heparin and fondaparinux for pharmacologic venous thromboembolic prophylaxis in critically ill patients with cancer.

J Thromb Haemost 2018 Dec 15;16(12):2492-2500. Epub 2018 Nov 15.

Department of Clinical Pharmacy, University of Colorado, Skaggs School of Pharmacy and Pharmaceutical Sciences, Anschutz Medical Campus, Aurora, CO, USA.

Essentials Critically ill cancer patients require pharmacologic prophylaxis for venous thromboembolism (VTE). Patients from 566 hospitals in the United States between 2010 and 2014 were included. Low-molecular-weight heparin (LMWH) prophylaxis was not associated in a reduction of VTE rates. Read More

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December 2018
16 Reads

The protease-activated receptor 4 Ala120Thr variant alters platelet responsiveness to low-dose thrombin and protease-activated receptor 4 desensitization, and is blocked by non-competitive P2Y inhibition.

J Thromb Haemost 2018 Dec 22;16(12):2501-2514. Epub 2018 Nov 22.

Program in Molecular Medicine and the Division of Hematology and Hematologic Malignancies, Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA.

Essentials The rs773902 SNP results in differences in platelet protease-activated receptor (PAR4) function. The functional consequences of rs773902 were analyzed in human platelets and stroke patients. rs773902 affects thrombin-induced platelet function, PAR4 desensitization, stroke association. Read More

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December 2018
5 Reads

Essentials for a successful registry: valid data, the right questions and timely execution.

Br J Dermatol 2018 Oct;179(4):805-806

Carl J. Herzog Professor of Dermatology, Harvard Medical School, Boston, MA, U.S.A.

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October 2018
8 Reads

Hemostatic abnormalities in patients with Ehlers-Danlos syndrome.

J Thromb Haemost 2018 Dec 8;16(12):2425-2431. Epub 2018 Nov 8.

A. Bianchi Bonomi Hemophilia and Thrombosis Center, University of Milan, Milan, Italy.

Essentials Ehlers-Danlos Syndrome (EDS) is a rare heterogeneous group of inherited collagen disorders. A cohort of EDS patients was investigated for bleeding tendency and hemostatic abnormalities. EDS is associated with an increased risk of bleeding. Read More

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December 2018
4 Reads

Safety of D-dimer testing as a stand-alone test for the exclusion of deep vein thrombosis as compared with other strategies.

J Thromb Haemost 2018 Dec 20;16(12):2471-2481. Epub 2018 Nov 20.

Department of Internal Medicine, Østfold Hospital Trust, Grålum, Norway.

Essentials The aim of deep vein thrombosis (DVT) diagnostic work-up is to maximize both safety and efficiency. We explored whether D-dimer is safe and efficient as a stand-alone test to exclude DVT. Our findings suggest it is a safe, efficient and simplified diagnostic strategy. Read More

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December 2018
2 Reads

Dissociation of GaN and AlN in APT: Electronic structure and stability in strong DC field.

J Chem Phys 2018 Oct;149(13):134310

Normandie Université, ENSICAEN, UNICAEN, CEA, CNRS, CIMAP, UMR 6252, BP 5133, F-14070 Caen Cedex 05, France.

We investigate from a theoretical point of view the stability of AlN and GaN dications produced under high static electric fields like those reached in Atom Probe Tomography (APT) experiments. By means of quantum chemical calculations of the electronic structure of these molecules, we show that their stability is governed by two independent processes. On the one hand, the spin-orbit coupling allows some molecular excited states to dissociate by inter-system crossing. Read More

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October 2018
2 Reads

Rapid determination of anticoagulating effects of dabigatran in whole blood with rotational thromboelastometry and a thrombin-based trigger.

J Thromb Haemost 2018 Dec 1;16(12):2462-2470. Epub 2018 Nov 1.

Department of Clinical Sciences, Division of Cardiovascular Medicine, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden.

Essentials A rapid test to detect thrombin inhibition by dabigatran would be valuable in acute situations. A thrombin-based trigger was applied in whole blood using rotation thromboelastometry. Effects of dabigatran were assessed in vitro and in samples from patients on dabigatran. Read More

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December 2018
1 Read

Genetic determinants of activity and antigen levels of contact system factors.

J Thromb Haemost 2018 Oct 4. Epub 2018 Oct 4.

Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Essentials Genetic variation may provide valuable insight into the role of the contact system in thrombosis. Explored associations of genetic variants with activity, antigen, and disease in RATIO study. Two novel loci were identified: KLKB1 rs4253243 for prekallikrein; KNG1 rs5029980 for HMWK levels. Read More

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October 2018
7 Reads

Combining multi-scale composite windows with hierarchical smoothing strategy for fingerprint orientation field computation.

Biomed Eng Online 2018 Oct 1;17(1):136. Epub 2018 Oct 1.

School of Information Science and Engineering, Electronic Engineering, Yunnan University, Chenggong District, Kunming, 650000, China.

Background: Orientation field (OF) plays a very significant role in automatic fingerprint recognition systems. Many algorithms have been proposed for the estimation of fingerprints' OF but it is hard to solve the dilemma of correcting spurious ridge structure and avoiding singularity location deviation, especially for poor images. So far, the following drawbacks still need to be solved for OF construction methods for practical application: (1) How to adaptively choose block scales to resolve the contradiction between accuracy and anti-noise, since small scale is beneficial to accuracy but is sensitive to noise, while large scale is more resistant to noise, but the accuracy is deteriorated. Read More

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October 2018
4 Reads

Dimeric FcγR ectodomains detect pathogenic anti-platelet factor 4-heparin antibodies in heparin-induced thromobocytopenia.

J Thromb Haemost 2018 Dec 20;16(12):2520-2525. Epub 2018 Nov 20.

Immune Therapies Group, Burnet Institute, Melbourne, Victoria, Australia.

Essentials FcγRIIa mediates life-threatening heparin-induced thrombocytopenia (HIT). Most anti-platelet factor (PF)4-heparin IgGs are not pathogenic so diagnosis of HIT is challenging. Dimeric rsFcγRIIa was used to quantify receptor-binding activity of anti-PF4-heparin antibodies. Read More

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December 2018
1 Read

Avatrombopag increases platelet count but not platelet activation in patients with thrombocytopenia resulting from liver disease.

J Thromb Haemost 2018 Dec 15;16(12):2515-2519. Epub 2018 Oct 15.

Center for Platelet Research Studies, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA, USA.

Essentials Thrombopoietin (TPO) lowers the threshold for platelet activation. TPO receptor agonists (RAs) may therefore also lead to platelet activation. Patients with chronic liver disease and thrombocytopenia participated in a randomized trial. Read More

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December 2018
13 Reads

Oxygen saturation or respiratory rate to improve risk stratification in hemodynamically stable patients with acute pulmonary embolism.

J Thromb Haemost 2018 Dec 15;16(12):2397-2402. Epub 2018 Oct 15.

Internal and Cardiovascular Medicine - Stroke Unit, University of Perugia, Perugia, Italy.

Essentials In acute pulmonary embolism (PE), risk stratification is essential to drive clinical management. Improving the 2014-ESC risk stratification strategy is crucial in hemodynamically stable patients. Oxygen saturation and respiratory rate improve risk stratification in hemodynamically stable PE. Read More

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December 2018
1 Read

Essentials of Head Trauma Imaging.

Semin Ultrasound CT MR 2018 Oct 8;39(5):469-480. Epub 2018 Feb 8.

Division of Neuroradiology, University of Cincinnati Medical Center, Cincinnati, OH.

Head trauma is a common indication for neuroimaging in the emergency room. CT is the modality of first choice, as it is quick, safe, and effective in evaluating for life-threatening intracranial hemorrhage and mass effect. CT is also best for evaluating for skull fractures, which may alter management and lead to further imaging studies. Read More

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October 2018
5 Reads

Management of Autoimmune Pancreatitis.

Gastrointest Endosc Clin N Am 2018 Oct 1;28(4):493-519. Epub 2018 Aug 1.

Section of Digestive Diseases, Yale University School of Medicine, Yale Center for Pancreatic Disease, Yale University, LMP 1080, 15 York Street, New Haven, CT 06510, USA. Electronic address:

Type 1 autoimmune pancreatitis (AIP) is an IgG-4-related systemic disease that can manifest as a pancreatic disorder or another disorder of presumed autoimmune origin. Type 2 disease is typically characterized by absent IgG-4-positive cells. As patients often present with acute pancreatitis, obstructive jaundice, or pancreatic mass, it is imperative to exclude malignancy, a more common diagnosis. Read More

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October 2018
1 Read

Determining the minimal clinically important difference for the PEmbQoL questionnaire, a measure of pulmonary embolism-specific quality of life.

J Thromb Haemost 2018 Dec 2;16(12):2454-2461. Epub 2018 Nov 2.

Center for Clinical Epidemiology, Lady Davis Institute, Montreal, QC, Canada.

Essentials The minimal clinically important difference (MCID) for PEmbQoL has not yet been determined. We estimated the MCID for PEmbQoL and its subscales via anchor- and distribution-based approaches. Our results indicate that MCID for PEmbQoL appears to be 15 points. Read More

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December 2018

Impact of anticoagulant choice on hospitalized bleeding risk when treating cancer-associated venous thromboembolism.

J Thromb Haemost 2018 Dec 24;16(12):2403-2412. Epub 2018 Oct 24.

School of Public Health, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA.

Essentials Bleeding risk by anticoagulant choice for cancer-associated venous thrombosis (CA-VTE) is unknown. 26 894 people with CA-VTE were followed for bleeding in a claims database in the United States. Hospitalized bleeding risk was similar with direct acting oral anticoagulants vs. Read More

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December 2018
24 Reads

Applying Human-Centered Design to the Development of an Asthma Essentials Kit for School-Aged Children and Their Parents.

J Pediatr Health Care 2018 Sep 15. Epub 2018 Sep 15.

Danielle Teska, Graduate Student, Human Centered Design and Engineering, University of Washington, Seattle, WA.

This study aimed to design and test an asthma essentials kit to support parent-child shared asthma management. Fourteen children (age range = 7-11 years) with asthma and their parents participated in this study. Development of the asthma essentials kit involved a generative phase, focused on understanding and designing to meet user needs, and an evaluative phase, which entailed narrowing, evaluating, and refining the asthma essentials kit. Read More

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September 2018
1.970 Impact Factor

Ultrasound elastography is useful to distinguish acute and chronic deep vein thrombosis.

J Thromb Haemost 2018 Dec 12;16(12):2482-2491. Epub 2018 Oct 12.

Department of Clinical and Experimental Medicine, Insubria University, Varese, Italy.

Essentials Ultrasound elastography uses tissue deformation to assess the relative quantification of its elasticity. Compression and duplex ultrasonography may be unable to correctly determine the thrombus age. Ultrasound elastography may be useful to distinguish between acute and chronic deep vein thrombosis. Read More

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December 2018
6 Reads