5,231 results match your criteria Essential Tremor


Motor features associated with cognition in non-demented individuals with essential tremor.

J Neurol Sci 2022 Jun 16;439:120323. Epub 2022 Jun 16.

Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA. Electronic address:

Introduction: Essential tremor (ET) is a clinically heterogeneous disease characterized by motor and non-motor features, including cognitive impairment. In a cross-sectional analysis, we determined whether the presence and severity of motor features of ET are associated with cognitive performance.

Methods: Participants enrolled in a study that used motor and neuropsychological measures to characterize a cohort of ET subjects. Read More

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Is essential tremor a family of diseases or a syndrome? A family of diseases.

Int Rev Neurobiol 2022 23;163:7-29. Epub 2022 Mar 23.

The Marlene and Paolo Fresco Institute for Parkinson's and Movement Disorders, New York University Langone Health, New York, NY, United States. Electronic address:

It is now well-established that essential tremor (ET) can manifest with different clinical presentations and progressions (i.e., upper limb tremor, head tremor, voice tremor, lower limb tremor, task- or position-specific tremor, or a combination of those). Read More

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Is essential tremor a degenerative disorder or an electric disorder? Degenerative disorder.

Authors:
Phyllis L Faust

Int Rev Neurobiol 2022 26;163:65-101. Epub 2022 Mar 26.

Department of Pathology and Cell Biology, Columbia University Vagelos College of Physicians and Surgeons and the New York Presbyterian Hospital, New York, NY, United States. Electronic address:

Essential tremor (ET) is a highly prevalent neurologic disease and is the most common of the many tremor disorders. ET is a progressive condition with marked clinical heterogeneity, associated with a spectrum of both motor and non-motor features. However, its disease mechanisms remain poorly understood. Read More

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Reduction of neuronal hyperexcitability with modulation of T-type calcium channel or SK channel in essential tremor.

Int Rev Neurobiol 2022 2;163:335-355. Epub 2022 May 2.

Department of Neurology, Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, United States. Electronic address:

Essential tremor is one of the most prevalent movement disorders. Propranolol and primidone are the first-line pharmacological therapies. They provide symptomatic control in less than 50% of patients. Read More

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Enhancing GABA inhibition is the next generation of medications for essential tremor.

Authors:
William Ondo

Int Rev Neurobiol 2022 21;163:317-334. Epub 2022 Mar 21.

Houston Methodist Hospital, Weill Cornel Medical School, Houston, TX, United States. Electronic address:

γ-Aminobutyric acid (GABA) is the most prevalent inhibitory CNS neurotransmitter. Activating GABA-A receptors hyperpolarizes cells via Cl influx, which inhibits action potentials. Although the exact pathophysiologies of tremor are incompletely understood, proposed neuroanatomy extensively implicates GABA pathways. Read More

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Is essential tremor a family of diseases or a syndrome? A syndrome.

Authors:
Sanjay Pandey

Int Rev Neurobiol 2022 21;163:31-59. Epub 2022 Mar 21.

Department of Neurology, Govind Ballabh Pant Postgraduate Institute of Medical Education and Research, New Delhi, India. Electronic address:

In a consensus statement, a task force of the "International Parkinson and Movement Disorder Society" (IPMDS) has recently proposed a two axes classification for tremor: axis I (clinical manifestations) and axis II (etiology). In the axis, I, the clinical features of tremor in a given patient are specified in terms of medical history, tremor characteristics, associated signs, and laboratory tests for some tremors leading to the discovery of axis 2 etiologies. Based on axis I sign and symptoms a specific clinical syndrome is diagnosed which have been categorized as isolated tremor syndrome (a syndrome consisting only of tremor) and combined tremor syndrome (consisting of tremor and other systemic or neurological signs). Read More

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Is essential tremor a disorder of GABA dysfunction? No.

Int Rev Neurobiol 2022 18;163:285-310. Epub 2022 Mar 18.

Icahn School of Medicine at Mount Sinai, New York City, NY, United States. Electronic address:

Although essential tremor is common, its underlying pathophysiology remains uncertain, and several hypotheses seek to explain the tremor mechanism. The GABA hypothesis states that disinhibition of deep cerebellar neurons due to reduced GABAergic input from Purkinje cells results in increased pacemaker activity, leading to rhythmic output to the thalamo-cortical circuit and resulting in tremor. However, some neuroimaging, spectroscopy, and pathology studies have not shown a clear or consistent GABA deficiency in essential tremor, and animal models have indicated that large reductions of Purkinje cell inhibition may improve tremor. Read More

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Is essential tremor a disorder of primary GABA dysfunction? Yes.

Int Rev Neurobiol 2022 21;163:259-284. Epub 2022 Mar 21.

Movement Disorders Unit, Department of Neurology, Sant Pau Hospital, Autonomous University of Barcelona, Catalonia, Spain. Electronic address:

Dysfunction in gamma-aminobutyric acid (GABA) neurotransmission has emerged as a prime suspect for the underlying neurochemical dysfunction in essential tremor (ET). This dysfunction has been termed the GABA hypothesis. We review findings to date supporting the 4 steps in this hypothesis in studies of cerebrospinal fluid, pathology, genetics, animal models, imaging, computational models, and human drugs, while not overlooking the evidence of negative studies and controversies. Read More

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Does essential tremor increase the risk of dementia? No.

Authors:
Alex Rajput

Int Rev Neurobiol 2022 31;163:233-253. Epub 2022 Mar 31.

Division of Neurology, Saskatchewan Movement Disorders Program, University of Saskatchewan/Saskatchewan Health Authority, Saskatoon, SK, Canada. Electronic address:

Essential tremor (ET) is the most common neurological cause of tremor affecting adult humans affecting about 6% of those over age 65 years. In the United States, dementia has a prevalence of 15% in those age 68 and older. Overlap of the two conditions is therefore not surprising. Read More

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Does essential tremor increase risk of cognitive impairment and dementia? Yes.

Int Rev Neurobiol 2022 9;163:195-231. Epub 2022 Apr 9.

Department of Neurology, Parkinson's Disease and Movement Disorders Center, Boston Medical Center, Boston, Massachusetts, United States; Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States. Electronic address:

Essential Tremor (ET), by definition, is a disorder of movement. Yet over the years, epidemiologic, clinical, pathologic, and neuroimaging studies have converged to reveal a cognitive side of ET. The cognitive symptoms in ET are heterogeneous and are likely to reflect heterogeneous underlying mechanisms. Read More

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Is inferior olive central to the pathophysiology of essential tremor? No.

Authors:
Mario Manto

Int Rev Neurobiol 2022 21;163:167-187. Epub 2022 Mar 21.

Unité des Ataxies Cérébelleuses, Service de Neurologie, CHU-Charleroi, Belgium; Service des Neurosciences, Université de Mons, Belgium. Electronic address:

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Is the inferior olive central to essential tremor? Yes.

Int Rev Neurobiol 2022 9;163:133-165. Epub 2022 Apr 9.

Neurology Service (W127), Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, United States.

We consider the question whether the inferior olive (IO) is required for essential tremor (ET). Much evidence shows that the olivocerebellar system is the main system capable of generating the widespread synchronous oscillatory Purkinje cell (PC) complex spike (CS) activity across the cerebellar cortex that would be capable of generating the type of bursting cerebellar output from the deep cerebellar nuclei (DCN) that could underlie tremor. Normally, synchronous CS activity primarily reflects the effective electrical coupling of IO neurons by gap junctions, and traditionally, ET research has focused on the hypothesis of increased coupling of IO neurons as the cause of hypersynchronous CS activity underlying tremor. Read More

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Is essential tremor a degenerative or an electrical disorder? Electrical disorder.

Authors:
Hyun Joo Cho

Int Rev Neurobiol 2022 21;163:103-128. Epub 2022 Mar 21.

Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States. Electronic address:

Essential tremor (ET) is one of the most common movement disorders, yet we do not have a complete understanding of its pathophysiology. From a phenomenology standpoint, ET is an isolated tremor syndrome of bilateral upper limb action tremor with or without tremor in other body locations. ET is a pathological tremor that arises from excessive oscillation in the central motor network. Read More

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Essential Tremor: Five New Things.

Neurol Clin Pract 2022 Apr;12(2):183-186

MedStar Georgetown University Hospital (AL), Washington, DC; and G.B. Pant Institute of Postgraduate Medical Education and Research (SP), New Delhi, India.

Purpose Of The Review: To highlight five new things in the research and clinical aspects of essential tremor (ET).

Recent Findings: The introduction of a new definition of ET and a new category "ET plus" were the major themes of the recent consensus statement. This new change demands a change in the approach to the clinical diagnosis of ET and related diseases. Read More

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Coherent Structural and Functional Network Changes after Thalamic Lesions in Essential Tremor.

Mov Disord 2022 Jun 23. Epub 2022 Jun 23.

Division "Clinical Functional Imaging," Department of Diagnostic and Interventional Radiology, University Hospital Bonn, Bonn, Germany.

Background: Magnetic resonance-guided focused ultrasound of the ventral intermediate nucleus is a novel incisionless ablative treatment for essential tremor (ET).

Objective: The aim was to study the structural and functional network changes induced by unilateral sonication of the ventral intermediate nucleus in ET.

Methods: Fifteen essential tremor patients (66. Read More

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Mediation of Tremor Control by the Decussating and Nondecussating Part of the Dentato-Rubro-Thalamic Tract in Deep Brain Stimulation in Essential Tremor: Which Part Should Be Stimulated?

Neuromodulation 2022 Jun 14. Epub 2022 Jun 14.

Department of Neurosurgery, University of Regensburg Medical Center, Regensburg, Germany; Center for Deep Brain Stimulation, University of Regensburg Medical Center, Regensburg, Germany.

Objectives: The dentato-rubro-thalamic tract (DRTT) has been found to play a major role in the mechanisms of tremor alleviation by deep brain stimulation (DBS) in essential tremor (ET). Still, the influence of the two different parts of the DRTT, consisting of crossing and nondecussating fibers, is not yet clear with respect to tremor reduction. The aim of this study was to assess the influence of the crossing and the nondecussating part of the DRTT on tremor control in ET. Read More

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Longitudinal Progression of Essential Tremor: Do Tremor Severity Scores Increase at a Uniform Rate?

Front Neurol 2022 31;13:871905. Epub 2022 May 31.

Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, United States.

Background: Few longitudinal studies assess the progression of essential tremor (ET). One unexplored issue is whether tremor severity increases across time at a uniform rate. That is, does the observed rate of change in tremor severity within a particular patient remain constant or vary across time? This question of intra-individual differences is particularly important since it reflects a primary patient concern-will the nature of change I have seen to date be what I can expect in the future?

Methods: ET cases were enrolled in a prospective, longitudinal study. Read More

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The Pharmacotherapeutic Landscape for Essential Tremor: Quantifying the Level of Unmet Need From a Patient and Epidemiologic Perspective.

Authors:
Elan D Louis

Clin Neuropharmacol 2022 Jun 11. Epub 2022 Jun 11.

Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX.

Abstract: Essential tremor (ET) is one of the most common neurological diseases. Despite this high prevalence, treatment options remain limited. Recent advances in mechanistic research have led to renewed interest in developing newer pharmacotherapeutic agents. Read More

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Which one is the superior target? A comparison and pooled analysis between posterior subthalamic area and ventral intermediate nucleus deep brain stimulation for essential tremor.

CNS Neurosci Ther 2022 Jun 10. Epub 2022 Jun 10.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Background/aims: The efficacy and safety of posterior subthalamic area (PSA) and ventral intermediate nucleus (VIM) deep brain stimulation (DBS) in the treatment of essential tremor (ET) have not been compared in large-scale studies. We conducted a secondary analysis to identify the superior target of ET-DBS treatment.

Methods: PubMed, Embase, Cochrane Library, and Google Scholar were searched for relevant studies before September 2021. Read More

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Overnight unilateral withdrawal of thalamic deep brain stimulation to identify reversibility of gait disturbances.

Exp Neurol 2022 Jun 6;355:114135. Epub 2022 Jun 6.

Charité - Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Movement Disorders and Neuromodulation Unit, Department of Neurology with Experimental Neurology, Charitéplatz 1, 10117 Berlin, Germany; Berlin School of Mind and Brain, Charité Universitätsmedizin Berlin, Unter den Linden 6, 10099 Berlin, Germany; German Center for Neurodegenerative Diseases (DZNE), Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin; NeuroCure Clinical Research Centre, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany. Electronic address:

Background: Gait disturbances are frequent side effects related to chronic thalamic deep brain stimulation (DBS) that may persist beyond cessation of stimulation.

Objective: We investigate the temporal dynamics and clinical effects of an overnight unilateral withdrawal of DBS on gait disturbances.

Methods: 10 essential tremor (ET) patients with gait disturbances following thalamic DBS underwent clinical and kinematic gait assessment ON DBS, after instant and after an overnight unilateral withdrawal of DBS of the hemisphere corresponding to the non-dominant hand. Read More

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Changes In The Cerebello-thalamo-cortical Network After MR-guided Focused Ultrasound Thalamotomy.

Brain Connect 2022 Jun 9. Epub 2022 Jun 9.

Stanford University, Radiology, Stanford, California, United States;

Object In recent years, transcranial MR-guided focused ultrasound (tcMRgFUS) has been established as a potential treatment option for movement disorders, including essential tremor. So far, however, little is known about the impact of tcMRgFUS on structural connectivity. The objective of this study was to detect microstructural changes in tremor- and motor-related white matter tracts in essential tremor patients treated with tcMRgFUS thalamotomy. Read More

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Development of Unilateral Peri-Lead Edema Into Large Cystic Cavitation After Deep Brain Stimulation: A Case Report.

Front Neurol 2022 23;13:886188. Epub 2022 May 23.

Department of Neurology, Yancheng Hospital Affiliated Southeast University Medical College, Yancheng, China.

Background And Importance: Deep brain stimulation (DBS) has been approved to treat a variety of movement disorders, including Parkinson's disease (PD), essential tremor, and dystonia. Following the DBS surgery, some perioperative and even delayed complications due to intracranial and hardware-related events could occur, which may be life-threatening and require immediate remedial measures.

Clinical Presentation: We report a case of an older woman with advanced PD who developed the unique complication of unilateral cyst formation at the tip of the DBS electrode after undergoing bilateral placement of subthalamic nucleus DBS. Read More

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Graph Theoretical Analysis of Structural Covariance Reveals the Relevance of Visuospatial and Attentional Areas in Essential Tremor Recovery After Stereotactic Radiosurgical Thalamotomy.

Front Aging Neurosci 2022 23;14:873605. Epub 2022 May 23.

Department of Clinical Neurosciences, Neurosurgery Service and Gamma Knife Center, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.

Essential tremor (ET) is the most common movement disorder. Its pathophysiology is only partially understood. Here, we leveraged graph theoretical analysis on structural covariance patterns quantified from morphometric estimates for cortical thickness, surface area, and mean curvature in patients with ET before and one year after (to account for delayed clinical effect) ventro-intermediate nucleus (Vim) stereotactic radiosurgical thalamotomy. Read More

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Essential tremor plus rest tremor: current concepts and controversies.

J Neural Transm (Vienna) 2022 Jul 7;129(7):835-846. Epub 2022 Jun 7.

Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", Neuroscience Section, University of Salerno, Via Allende, Baronissi, SA, Italy.

Since the initial description of Essential Tremor (ET), the entity of ET with rest tremor has proven to be a controversial concept. Some authors argued it could be a late manifestation of ET, others suggested it could be a variant of ET, yet others suggested it could represent a transitional state between ET and Parkinson's disease. The novel tremor classification has proposed the construct of ET-plus to differentiate patients with rest tremor from pure ET. Read More

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Effects of Deep Brain Stimulation on Lower Urinary Tract Function in Neurological Patients.

Eur Urol Focus 2022 May 31. Epub 2022 May 31.

Department of Neuro-Urology, Balgrist University Hospital, University of Zürich, Zürich, Switzerland. Electronic address:

Background: Deep brain stimulation (DBS) has clear beneficial effects on motor signs in movement disorders, but much less is known about its impact on lower urinary tract (LUT) function.

Objective: To evaluate the effects of DBS on LUT function in patients affected by movement disorders.

Design, Setting, And Participants: We prospectively enrolled 58 neurological patients affected by movement disorders, who were planned to receive DBS. Read More

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Altered thalamic connectivity due to focused ultrasound thalamotomy in patients with essential tremor.

World Neurosurg 2022 May 31. Epub 2022 May 31.

Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan.

Background: Although stereotactic ablation surgery is known to ameliorate involuntary movement dramatically, little is known regarding alterations in whole-brain networks due to disruption of the deep brain nucleus. To explore changes in the whole-brain network after thalamotomy, we analyzed structural and functional connectivity alterations using resting-state functional magnetic resonance imaging (rs-fMRI) and diffusion tensor imaging (DTI) in patients with essential tremor who had undergone focused ultrasound (FUS) thalamotomy.

Methods: Seven patients with intractable essential tremors and seven age-matched healthy controls were enrolled in the study. Read More

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Ability of Swept-source OCT and OCT-angiography to detect neuroretinal and vasculature changes in patients with Parkinson disease and essential tremor.

Eye (Lond) 2022 Jun 1. Epub 2022 Jun 1.

Ophthalmology Department, Miguel Servet University Hospital, Zaragoza, Spain.

Background/objectives: To evaluate the ability of swept-source optical coherence tomography (SS-OCT) implemented with angiography analysis (SS-OCTA) to detect neuro-retinal and vasculature changes in patients with Parkinson's disease (PD) and essential tremor (ET), and to distinguish between both pathologies.

Subjects/methods: A total 42 PD and 26 ET patients and 146 controls underwent retinal evaluation using SS-OCT plus OCT-Angio™. The macular (m) and peripapillary (p) retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL), and macular vasculature were assessed. Read More

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Differentiation of Parkinson's disease tremor and essential tremor based on a novel hand posture.

Clin Park Relat Disord 2022 21;7:100146. Epub 2022 May 21.

Department of Neurology, University Hospital Zurich, University of Zurich, Zurich Switzerland.

Background: Tremor is one of the most common movement disorders but the correct diagnosis of tremor disorders, especially the differentiation between Parkinson's disease tremor (PT) and essential tremor (ET) remains a challenge for clinicians.

Method: We examined a novel hand position to distinguish PT from ET. We prospectively collected accelerometric tremor data in 14 ET patients and 14 PT patients with arms and hands fully stretched against arms stretched and hands relaxed, i. Read More

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The Conundrum of Dystonia in Essential Tremor Patients: How does One Classify these Cases?

Tremor Other Hyperkinet Mov (N Y) 2022 13;12:15. Epub 2022 May 13.

Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Background: The relationship between essential tremor (ET) and dystonia has been long debated and the boundaries between these disorders remain unclear. Here, we highlight the diagnostic uncertainty that can arise when observing dystonic postures in patients who have received ET diagnoses.

Methods: An international panel of seven movement disorders neurologists from five countries reviewed the clinical history and videotaped neurological examinations of five individuals diagnosed with ET who also had various features of dystonia on neurological examination. Read More

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Transcranial high-intensity Magnetic Resonance-guided focused ultrasound (tcMRgFUS) - safety and impacts on tremor severity and quality of life.

Parkinsonism Relat Disord 2022 May 23;100:6-12. Epub 2022 May 23.

Department of Neurology, University Hospital Bonn, Germany; German Centre of Neurodegenerative Diseases (DZNE), Bonn, Germany.

Introduction: Transcranial high-intensity Magnetic Resonance-guided Focused Ultrasound (tcMRgFUS) is a technique for treatment of severe, medication-refractory Essential Tremor (ET). We summarize 1-year follow-up results focusing on clinical and safety parameters and impacts on quality of life.

Methods: A total of 45 patients with severe, medication-refractory ET were treated with tcMRgFUS thalamotomy. Read More

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