4,039 results match your criteria Essential Tremor


Correction to: Cranial MR-guided Focused Ultrasound for Essential Tremor : Technical Considerations and Image Guidance.

Clin Neuroradiol 2018 Dec 14. Epub 2018 Dec 14.

Department of Neurosurgery, Weill Cornell Medicine, New York-Presbyterian Hospital, 525 East 68th Street, 10065, New York, NY, USA.

Correction to:Clin Neuroradiol 2018 https://doi.org/10.1007/s00062-018-0709-x The original version of this article unfortunately contained a mistake. Read More

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http://dx.doi.org/10.1007/s00062-018-0751-8DOI Listing
December 2018

Pretherapeutic resting-state fMRI profiles are associated with MR signature volumes after stereotactic radiosurgical thalamotomy for essential tremor.

Authors:

J Neurosurg 2018 Dec;129(Suppl1):63-71

OBJECTIVEEssential tremor (ET) is the most common movement disorder. Drug-resistant ET can benefit from standard stereotactic deep brain stimulation or radiofrequency thalamotomy or, alternatively, minimally invasive techniques, including stereotactic radiosurgery (SRS) and high-intensity focused ultrasound, at the level of the ventral intermediate nucleus (Vim). The aim of the present study was to evaluate potential correlations between pretherapeutic interconnectivity (IC), as depicted on resting-state functional MRI (rs-fMRI), and MR signature volume at 1 year after Vim SRS for tremor, to be able to potentially identify hypo- and hyperresponders based only on pretherapeutic neuroimaging data. Read More

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http://dx.doi.org/10.3171/2018.7.GKS18752DOI Listing
December 2018

Assessment of Lead Exposure and Urinary-δ-aminolevulinic Acid Levels in Male Lead Acid Battery Workers in Tamil Nadu, India.

J Health Pollut 2018 Mar 12;8(17):6-13. Epub 2018 Mar 12.

Regional Occupational Health Centre, (Southern) Bengaluru, Karnataka, India.

Background: Exposure to lead (Pb) affects multiple health outcomes and physiological systems. In adults, even small increases in blood Pb levels have been associated with decreased glomerular filtration rate, increased risk of hypertension and increased incidence of essential tremor. To date, there have been few Pb-exposure assessments using the United States Occupational Health and Safety Administration (OSHA) regulations. Read More

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http://dx.doi.org/10.5696/2156-9614-8.17.6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221436PMC

Nigral iron deposition in common tremor disorders.

Mov Disord 2018 Dec 10. Epub 2018 Dec 10.

Department of Neurology, Medical University of Graz, Graz, Austria.

Objective: We investigated R2* relaxation rates as a marker of iron content in the substantia nigra in patients with common tremor disorders and explored their diagnostic properties.

Methods: Mean nigral R2* rates were measured in 40 patients with tremor-dominant Parkinson's disease (PD), 15 with tremor in dystonia, 25 with essential tremor, and 25 healthy controls.

Results: Tremor-dominant PD patients had significantly higher nigral R2* values (34. Read More

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http://dx.doi.org/10.1002/mds.27549DOI Listing
December 2018

White matter differences between essential tremor and Parkinson disease.

Neurology 2018 Nov 30. Epub 2018 Nov 30.

From the Departments of Radiology and Radiological Sciences (M.R.J., M.J.D.), Neurological Surgery (D.J.E., P.E.K.), Biostatistics (Y.-C.L., H.K.), Neurology (P.T., P.H., M.J.D.), and Psychiatry (M.J.D.), Vanderbilt University Medical Center, Nashville, TN; Department of Pathophysiology and Transplantation (G.F.) University of Milan, Italy; and Chemical and Physical Biology Program (K.J.P.) and Departments of Electrical Engineering (B.A.L., B.M.D.), Computer Engineering (B.A.L., B.M.D.), Computer Science and Biomedical Engineering (B.A.L., B.M.D.), and Neurology (D.O.C.), Vanderbilt University, Nashville, TN.

Objective: To assess white matter integrity in patients with essential tremor (ET) and Parkinson disease (PD) with moderate to severe motor impairment.

Methods: Sedated participants with ET (n = 57) or PD (n = 99) underwent diffusion tensor imaging (DTI) and fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity values were computed. White matter tracts were defined using 3 well-described atlases. Read More

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http://dx.doi.org/10.1212/WNL.0000000000006694DOI Listing
November 2018
1 Read
8.286 Impact Factor

Treatment of Patients with Vocal Fold Atrophy and Comorbid Essential Voice Tremor: Long-Term Injection Augmentation Outcomes After Successful Diagnostic Vocal Fold Injection Augmentation.

J Voice 2018 Nov 29. Epub 2018 Nov 29.

Division of Otolaryngology, Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts. Electronic address:

Objective: Vocal fold injection augmentation (VFIA) is employed diagnostically for patients with subtle glottic insufficiency. Its use in patients with both vocal fold atrophy and benign essential voice tremor (EVT) has been reported but not after durable augmentation. This study intends to evaluate the success of durable VFIA using either autologous fat or calcium hydroxylapatite in patients with both vocal fold atrophy and comorbid EVT. Read More

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http://dx.doi.org/10.1016/j.jvoice.2018.11.004DOI Listing
November 2018

Action Control Deficits in Patients With Essential Tremor.

J Int Neuropsychol Soc 2018 Dec 3:1-9. Epub 2018 Dec 3.

1Department of Neurology,Vanderbilt University Medical Center,Nashville, Tennessee.

Objectives: Essential tremor (ET) is a movement disorder characterized by action tremor which impacts motor execution. Given the disrupted cerebellar-thalamo-cortical networks in ET, we hypothesized that ET could interfere with the control mechanisms involved in regulating motor performance. The ability to inhibit or stop actions is critical for navigating many daily life situations such as driving or social interactions. Read More

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http://dx.doi.org/10.1017/S1355617718001054DOI Listing
December 2018
1 Read

Treatment of psychiatric disturbances in common hyperkinetic movement disorders.

Expert Rev Neurother 2018 Dec 1. Epub 2018 Dec 1.

b Department of Human Neurosciences , Sapienza University of Rome , Rome.

Introduction: This paper reviews studies that have assessed the treatment of psychiatric disturbances in dystonia, tic disorders, Tourette syndrome, Huntington's disease and essential tremor. Areas covered: We searched for papers in English in Pubmed using the following keywords: blepharospasm, cervical dystonia, arm dystonia, laryngeal dystonia, spasmodic dysphonia, tic disorders, Tourette syndrome, Huntington's chorea, essential tremor, depression, anxiety, obsessive compulsive disorders, attention deficit hyperactivity disorders, psychosis, apathy. Expert commentary: Although psychiatric disturbances are frequent in hyperkinetic movement disorders, few controlled studies have assessed the treatment of psychiatric disturbances in such disorders. Read More

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https://www.tandfonline.com/doi/full/10.1080/14737175.2019.1
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http://dx.doi.org/10.1080/14737175.2019.1555475DOI Listing
December 2018
4 Reads

Outcomes in Lesion Surgery versus Deep Brain Stimulation in Patients with Tremor: A Systematic Review and Meta-analysis.

World Neurosurg 2018 Nov 27. Epub 2018 Nov 27.

Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Introduction: Optimal surgical strategy for patients with tremor remains uncertain. We conducted a systematic review and meta-analysis evaluating randomized controlled trials of deep brain stimulation (DBS) and lesion surgery (LS) in treatment of tremor.

Methods: We searched PubMed, Embase and the Cochrane database to include randomized clinical trials with either lesion surgery, deep brain stimulation, or controls. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.11.175DOI Listing
November 2018

Targeting the posterior subthalamic area for essential tremor: proposal for MRI-based anatomical landmarks.

Authors:

J Neurosurg 2018 Oct 1:1-8. Epub 2018 Oct 1.

OBJECTIVEDeep brain stimulation (DBS) of the posterior subthalamic area (PSA) is an alternative to thalamic DBS for the treatment of essential tremor (ET). The dentato-rubro-thalamic tract (DRTT) has recently been proposed as the anatomical substrate underlying effective stimulation. For clinical purposes, depiction of the DRTT mainly depends on diffusion tensor imaging (DTI)-based tractography, which has some drawbacks. Read More

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http://dx.doi.org/10.3171/2018.4.JNS18373DOI Listing
October 2018

Serum soluble lymphocyte activation gene-3 as a diagnostic biomarker in Parkinson's disease: A pilot multicenter study.

Mov Disord 2018 Nov 28. Epub 2018 Nov 28.

Department of Neurology & Co-innovation Center of Neuroregeneration, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Objective: Lymphocyte activation gene-3 (LAG-3) could mediate pathological α-synuclein transmission in neurodegeneration and may be involved in the pathogenesis of Parkinson's disease (PD). The aim of the present study was to explore soluble LAG-3 (sLAG-3) as a potential diagnostic biomarker for PD.

Methods: Serum sLAG-3 concentrations were measured by a quantitative ELISA for patients with PD, essential tremor (ET) and age- and sex-matched controls. Read More

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http://dx.doi.org/10.1002/mds.27569DOI Listing
November 2018
4 Reads

Suppressing bursting synchronization in a modular neuronal network with synaptic plasticity.

Cogn Neurodyn 2018 Dec 12;12(6):625-636. Epub 2018 Aug 12.

2Department of Applied Mathematics, Northwestern Polytechnical University, Xi'an, 710072 People's Republic of China.

Excessive synchronization of neurons in cerebral cortex is believed to play a crucial role in the emergence of neuropsychological disorders such as Parkinson's disease, epilepsy and essential tremor. This study, by constructing a modular neuronal network with modified Oja's learning rule, explores how to eliminate the pathological synchronized rhythm of interacted busting neurons numerically. When all neurons in the modular neuronal network are strongly synchronous within a specific range of coupling strength, the result reveals that synaptic plasticity with large learning rate can suppress bursting synchronization effectively. Read More

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http://dx.doi.org/10.1007/s11571-018-9498-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233333PMC
December 2018
1 Read

Tremor.

Handb Clin Neurol 2018 ;159:283-301

Movement Disorders Unit, Department of Neurology, Westmead Hospital, Sydney, NSW, Australia; Sydney Medical School, University of Sydney, Sydney, NSW, Australia. Electronic address:

Tremor is a phenomenon observed in a broad spectrum of diseases with different pathophysiologies. While patients with tremor may not complain in the clinic of symptoms of imbalance, gait difficulties, or falls, laboratory research studies using quantitative analysis of gait and posture and neurophysiologic techniques have demonstrated impaired gait and balance across a variety of tremor etiologies. These findings have been supported by careful epidemiologic studies assessing symptoms of imbalance. Read More

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http://dx.doi.org/10.1016/B978-0-444-63916-5.00018-5DOI Listing
January 2018
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Quantitative Assessment of Pathological Tau Burden in Essential Tremor: A Postmortem Study.

J Neuropathol Exp Neurol 2019 Jan;78(1):31-37

Department of Pathology.

Essential tremor (ET) patients develop more cognitive impairment and dementia than controls, although there are surprisingly few data on the neuropathological basis for cognitive changes in ET. In this postmortem study, we assessed tau and other pathologies in 26 ET cases and 73 controls (non-ET) (1:3 matching). The mean age = 88. Read More

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https://academic.oup.com/jnen/advance-article/doi/10.1093/jn
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http://dx.doi.org/10.1093/jnen/nly104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289218PMC
January 2019
3 Reads

Peroxisome proliferator-activated receptor-γ activation attenuates harmaline-induced cognitive impairments in rats.

J Clin Neurosci 2018 Nov 21. Epub 2018 Nov 21.

Intracellular Recording Lab, Neuroscience Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman.

Cognitive and motor disturbances are serious concerns of the tremors induced by motor disorders. Despite the lack of effective clinical treatment, some potential therapeutic agents have been used to alleviate the cognitive symptoms in the animal models of tremor. Recent studies have shown that PPAR-γ agonists have neuroprotective effects. Read More

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http://dx.doi.org/10.1016/j.jocn.2018.11.004DOI Listing
November 2018
2 Reads
1.318 Impact Factor

Tests of clustering thalamic nuclei based on various dMRI models in the squirrel monkey brain.

Proc SPIE Int Soc Opt Eng 2018 Mar;10578

Biomedical Engineering, Vanderbilt University, Nashville, TN, USA 37235.

Background: Clustering thalamic nuclei is important for both research and clinical purposes. For example, ventral intermediate nuclei in thalami serve as targets in both deep brain stimulation neurosurgery and radiosurgery for treating patients suffering from movement disorders (e.g. Read More

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http://dx.doi.org/10.1117/12.2293879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241534PMC

Confined Thalamic Deep Brain Stimulation in Refractory Essential Tremor.

Stereotact Funct Neurosurg 2018 19;96(5):296-304. Epub 2018 Nov 19.

Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee,

Background: Thalamic ventral intermediate nucleus (VIM) deep brain stimulation (DBS) is an effective therapy for medication-refractory essential tremor (ET). However, 13-40% of patients with an initially robust tremor efficacy lose this benefit over time despite reprogramming attempts. At our institution, a cohort of ET patients with VIM DBS underwent implantation of a second anterior (ventralis oralis anterior; VOA) DBS lead to permit "confined stimulation. Read More

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https://www.karger.com/Article/FullText/493546
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http://dx.doi.org/10.1159/000493546DOI Listing
November 2018
4 Reads

MRI-guided laser interstitial thermal thalamotomy for medically intractable tremor disorders.

Mov Disord 2018 Nov 19. Epub 2018 Nov 19.

Tri-State Neurosurgery, Willis Knighton Health System, Shreveport, Louisiana, USA.

Introduction: Medically intractable tremors are a common, difficult clinical situation. Deep brain stimulation decreases Parkinson's disease resting tremor and essential tremor, but not all patients are candidates from a diagnostic, medical, or social standpoint, prompting the need for alternative surgical strategies.

Methods: We describe 13 patients with medically intractable tremor treated with laser interstitial thermal thalamotomy performed under general anesthesia using live MRI-guidance and the Clearpoint stereotactic system. Read More

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http://doi.wiley.com/10.1002/mds.27545
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http://dx.doi.org/10.1002/mds.27545DOI Listing
November 2018
5 Reads

Focused ultrasound thalamotomy location determines clinical benefits in patients with essential tremor.

Brain 2018 Dec;141(12):3405-3414

University Health Network, Toronto, ON, Canada.

Magnetic resonance guided focused ultrasound (MRgFUS) thalamotomy is a novel and minimally invasive ablative treatment for essential tremor. The size and location of therapeutic lesions producing the optimal clinical benefits while minimizing adverse effects are not known. We examined these relationships in patients with essential tremor undergoing MRgFUS. Read More

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http://fdslive.oup.com/www.oup.com/pdf/production_in_progres
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http://dx.doi.org/10.1093/brain/awy278DOI Listing
December 2018
6 Reads
9.196 Impact Factor

A machine-learning approach to volitional control of a closed-loop deep brain stimulation system.

J Neural Eng 2018 Nov 16;16(1):016004. Epub 2018 Nov 16.

Department of Electrical Engineering, University of Washington, Seattle, WA, United States of America. Graduate Program in Neuroscience, University of Washington, Seattle, WA, United States of America.

Objective: Deep brain stimulation (DBS) is a well-established treatment for essential tremor, but may not be an optimal therapy, as it is always on, regardless of symptoms. A closed-loop (CL) DBS, which uses a biosignal to determine when stimulation should be given, may be better. Cortical activity is a promising biosignal for use in a closed-loop system because it contains features that are correlated with pathological and normal movements. Read More

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http://stacks.iop.org/1741-2552/16/i=1/a=016004?key=crossref
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http://dx.doi.org/10.1088/1741-2552/aae67fDOI Listing
November 2018
7 Reads

On the need for adaptive learning in on-demand Deep Brain Stimulation for Movement Disorders.

Conf Proc IEEE Eng Med Biol Soc 2018 Jul;2018:2190-2193

The results presented in this paper indicate that future on-demand Deep Brain Stimulation (DBS) systems for chronic use in patients with movement disorders should continuously and adaptively "learn" in order to maintain high symptom control efficacy. In this work, two machine learning algorithms-Decision Tree and LArge Memory STorage And Retrieval (LAMSTAR) neural network, both with surface Electromyography and accelerometry as control signals-are used to predict onset of tremor after DBS has been switched off in two patients, one suffering from Parkinson's disease and the other from essential tremor. The novelty of this work is that training and testing are done by using different data recorded during sessions at least one week apart. Read More

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http://dx.doi.org/10.1109/EMBC.2018.8512664DOI Listing

Characterizing the Normative Voice Tremor Frequency in Essential Vocal Tremor.

JAMA Otolaryngol Head Neck Surg 2018 Oct 25. Epub 2018 Oct 25.

Division of Otolaryngology, Department of Surgery, Wisconsin Surgical Outcomes Research Program, University of Wisconsin-Madison.

Importance: Essential vocal tremor (EVT) is a neurologic voice disorder characterized by periodic fluctuations in pitch and loudness that can hinder intelligibility. Defining the normative range of vocal tremor frequency may assist in diagnosis and provide insight into disease mechanisms.

Objective: To characterize the normative voice tremor frequency in EVT (in hertz). Read More

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https://jamanetwork.com/journals/jamaotolaryngology/fullarti
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http://dx.doi.org/10.1001/jamaoto.2018.2566DOI Listing
October 2018
5 Reads

Motor Unit-Driven Identification of Pathological Tremor in Electroencephalograms.

Front Neurol 2018 29;9:879. Epub 2018 Oct 29.

Faculty of Electrical Engineering and Computer Science, University of Maribor, Maribor, Slovenia.

Traditional studies on the neural mechanisms of tremor use coherence analysis to investigate the relationship between cortical and muscle activity, measured by electroencephalograms (EEG) and electromyograms (EMG). This methodology is limited by the need of relatively long signal recordings, and it is sensitive to EEG artifacts. Here, we analytically derive and experimentally validate a new method for automatic extraction of the tremor-related EEG component in pathological tremor patients that aims to overcome these limitations. Read More

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https://www.frontiersin.org/article/10.3389/fneur.2018.00879
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http://dx.doi.org/10.3389/fneur.2018.00879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215829PMC
October 2018
3 Reads

Distinct cortical responses evoked by electrical stimulation of the thalamic ventral intermediate nucleus and of the subthalamic nucleus.

Neuroimage Clin 2018 3;20:1246-1254. Epub 2018 Nov 3.

Department of Neurology, Medical Faculty, Heinrich-Heine University Düsseldorf, Moorenstrasse 5, 40225 Düsseldorf, Germany; Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine University Düsseldorf, Moorenstrasse 5, 40225 Düsseldorf, Germany. Electronic address:

Objective: To investigate the spatial and temporal pattern of cortical responses evoked by deep brain stimulation (DBS) of the subthalamic nucleus (STN) and ventral intermediate nucleus of the thalamus (VIM).

Methods: We investigated 7 patients suffering from Essential tremor (ET) and 7 patients with Parkinson's Disease (PD) following the implantation of DBS electrodes (VIM for ET patients, STN for PD patients). Magnetoencephalography (MEG) was used to record cortical responses evoked by electric stimuli that were applied via the DBS electrode in trains of 5 Hz. Read More

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http://dx.doi.org/10.1016/j.nicl.2018.11.001DOI Listing
November 2018
1 Read

An Update On The Neurochemistry Of Essential Tremor.

Curr Med Chem 2018 Nov 11. Epub 2018 Nov 11.

University Institute of Molecular Pathology Biomarkers, UNEx. ARADyAL Instituto de Salud Carlos III, Cáceres. Spain.

Background: The pathophysiology and neurochemical mechanisms of essential tremor (ET) are not fully understood, because only a few post-mortem studies have been reported, and the lack of a good experimental model for this disease.

Objective: The main aim of this review is to update data regarding the neurochemical features of ET. Alterations of certain catecholamine systems, the dopaminergic, serotonergic, GABAergic, noradrenergic, and adrenergic systems have been described, and are the object of this revision. Read More

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http://www.eurekaselect.com/167229/article
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http://dx.doi.org/10.2174/0929867325666181112094330DOI Listing
November 2018
3 Reads

More unaffected first-degree relatives of essential tremor cases have mild cognitive deficits than age-matched controls.

Parkinsonism Relat Disord 2018 Oct 31. Epub 2018 Oct 31.

Department of Neurology, Yale School of Medicine, Yale University, New Haven, CT, USA; Department of Chronic Disease Epidemiology, Yale School of Public Health, Yale University, New Haven, CT, USA; Center for Neuroepidemiology and Clinical Neurological Research, Yale School of Medicine, Yale University, New Haven, CT, USA. Electronic address:

Background: In numerous case-control studies, essential tremor (ET) has been associated with cognitive impairment. ET is often familial. However, cognitive impairment has not been studied in family members of ET cases. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13538020183046
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http://dx.doi.org/10.1016/j.parkreldis.2018.10.030DOI Listing
October 2018
7 Reads

Animal Models of Tremor: Relevance to Human Tremor Disorders.

Tremor Other Hyperkinet Mov (N Y) 2018 9;8:587. Epub 2018 Oct 9.

Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.

Background: Tremor is the most common movement disorder; however, the pathophysiology of tremor remains elusive. While several neuropathological alterations in tremor disorders have been observed in post-mortem studies of human brains, a full understanding of the relationship between brain circuitry alterations and tremor requires testing in animal models. Additionally, tremor animal models are critical for our understanding of tremor pathophysiology, and/or to serve as a platform for therapy development. Read More

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http://www.tremorjournal.org/index.php/tremor/article/view/5
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http://dx.doi.org/10.7916/D89S37MVDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214818PMC
December 2018
10 Reads

Primary Writing Tremor.

Tremor Other Hyperkinet Mov (N Y) 2018 6;8:586. Epub 2018 Sep 6.

Division of Movement Disorders, Department of Neurology, Yale School of Medicine, Yale University, New Haven, CT, USA.

Background: Primary writing tremor (PWT) is a rare condition; tremor occurs primarily while writing rather than during other tasks.

Phenomenology Shown: We illustrate the phenomenology of PWT and point out associated subtle dystonic posturing on neurological examination.

Educational Value: PWT is a tremor disorder that shares clinical features with both dystonia and essential tremor. Read More

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http://dx.doi.org/10.7916/D8T740ZZDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214817PMC
December 2018
1 Read

Valproate: It's Effects on Hair.

Int J Trichology 2018 Jul-Aug;10(4):150-153

Yenepoya Research Centre, Yenepoya University, Mangalore, Karnataka, India.

Valproate is a drug used in the treatment of various seizure disorders, bipolar disorder, migraine prophylaxis, and off label in many indications by various specialists. The common adverse drug reactions reported on valproate administration are tremor, weight gain, gastrointestinal disturbances, liver dysfunction, metabolic acidosis, thrombocytopenia, and hair loss. An internet search with keywords "valproate" and "hair" was done on Google Search and PubMed for articles related to the topic. Read More

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http://dx.doi.org/10.4103/ijt.ijt_10_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192236PMC
November 2018
5 Reads

Magnetic Resonance-Guided Focused Ultrasound in Neurosurgery: Taking Lessons from the Past to Inform the Future.

J Korean Med Sci 2018 Oct 4;33(44):e279. Epub 2018 Oct 4.

Department of Neurosurgery, Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea.

Magnetic resonance-guided focused ultrasound (MRgFUS) is a new emerging neurosurgical procedure applied in a wide range of clinical fields. It can generate high-intensity energy at the focal zone in deep body areas without requiring incision of soft tissues. Although the effectiveness of the focused ultrasound technique had not been recognized because of the skull being a main barrier in the transmission of acoustic energy, the development of hemispheric distribution of ultrasound transducer phased arrays has solved this issue and enabled the performance of true transcranial procedures. Read More

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http://dx.doi.org/10.3346/jkms.2018.33.e279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200905PMC
October 2018
1 Read
1.253 Impact Factor

Investigating the association and causal relationship between restless legs syndrome and essential tremor.

Parkinsonism Relat Disord 2018 Oct 19. Epub 2018 Oct 19.

Montreal Neurological Institute, McGill University, Montréal, Quebec, Canada; Department of Neurology and Neurosurgery, McGill University, Montréal, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2018.10.022DOI Listing
October 2018
1 Read

Comparison of the Fahn-Tolosa-Marin Clinical Rating Scale and the Essential Tremor Rating Assessment Scale.

Mov Disord Clin Pract 2018 Jan-Feb;5(1):60-65. Epub 2017 Nov 23.

Department of Neurology Southern Illinois University School of Medicine Springfield IL.

Background: The Fahn-Tolosa-Marin Clinical Rating Scale for Tremor (FTM) has been used in large trials for essential tremor (ET), but its anchors for ratings from 0 to 4 of upper limb tremor are probably too low for patients with severe tremor (tremor amplitude >4 cm; grade 4). The Essential Tremor Rating Assessment Scale (TETRAS) is a validated clinical scale designed specifically for the assessment of ET severity. TETRAS has anchors that span a larger range of tremor amplitudes (>20 cm = grade 4), making it more suitable for assessing patients with severe ET. Read More

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http://doi.wiley.com/10.1002/mdc3.12560
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http://dx.doi.org/10.1002/mdc3.12560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174461PMC
November 2017
14 Reads

Ventral Intermediate Nucleus Versus Zona Incerta Region Deep Brain Stimulation in Essential Tremor.

Mov Disord Clin Pract 2018 Jan-Feb;5(1):75-82. Epub 2017 Nov 27.

Department of Neurology Center for Movement Disorders and Neurorestoration University of Florida College of Medicine Gainesville FL USA.

Background: The ventral intermediate nucleus (VIM) is the target of choice for Essential Tremor (ET) deep brain stimulation (DBS). Renewed interest in caudal zona incerta (cZI) stimulation for tremor control has recently emerged and some groups believe this approach may address long-term reduction of benefit seen with VIM-DBS.

Objectives: To compare clinical outcomes and DBS programming in the long-term between VIM and cZI neurostimulation in ET-DBS patients. Read More

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http://doi.wiley.com/10.1002/mdc3.12565
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http://dx.doi.org/10.1002/mdc3.12565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174382PMC
November 2017
7 Reads

Is deep brain stimulation therapy underutilized for movement disorders?

Expert Rev Neurother 2018 12 15;18(12):899-901. Epub 2018 Nov 15.

a Fixel Center for Neurological Disorders, Department of Neurology , University of Florida , Gainesville , FL , USA.

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http://dx.doi.org/10.1080/14737175.2018.1538791DOI Listing
December 2018

[Hardware- software complex for the differential diagnosis and evaluation of the effictiveness of treatment of extrapyramidal diseases].

Authors:
O E Khutorskaya

Zh Nevrol Psikhiatr Im S S Korsakova 2018 ;118(6. Vyp. 2):99-104

Trapeznikov Institute of Control Sciences of Russian Academy of Sciences, Moscow, Russia.

The hardware-software system of differential diagnosis and evaluation of the efficacy of treatment of a number of extrapyramidal diseases (Parkinson's disease, essential tremor, idiopathic cervical dystonia) is based on the methodology of special processing of the electrical activity of muscles (EMG). The system defines the diagnosis for each investigated muscle, and determine various forms of extrapyramidal diseases including early preclinical ones. The system allows viewing the dynamics of changes in the patient's state, both in numerical characteristics and in the graphic interpretation, and evaluates the efficacy of various forms of treatment (medicament, surgical, etc. Read More

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http://dx.doi.org/10.17116/jnevro201811806299DOI Listing
January 2018
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[Diagnosis and management of essential tremor].

Zh Nevrol Psikhiatr Im S S Korsakova 2018 ;118(6. Vyp. 2):64-72

Centre of Extrapyramidal Diseases Department of Neurology, Russian Medical Academy of Continuous Professional Education, Moscow, Russia.

Essential tremor (ET) is the most common extrapyramidal disease and one of the most frequent neurological diseases. The main presentation of ET is a progressive bilateral (kinetic-postural) hand tremor. The prevalence in people over 65 years is 5%, it increases with age up to 22% in people over 95 years. Read More

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http://dx.doi.org/10.17116/jnevro201811806264DOI Listing
January 2018

Cortical dynamics within and between parietal and motor cortex in essential tremor.

Mov Disord 2018 Oct 21. Epub 2018 Oct 21.

Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA.

Background: Evidence from functional imaging in essential tremor suggests that activity within parietal and motor cortices may be associated with worsening of tremor at increased visual feedback.

Objectives: Examine how cortical oscillations within these regions and the connectivity between these regions is associated with worsening of tremor in essential tremor in response to high visual feedback.

Method: The study included 24 essential tremor participants and 17 controls. Read More

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http://doi.wiley.com/10.1002/mds.27522
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http://dx.doi.org/10.1002/mds.27522DOI Listing
October 2018
7 Reads

Procedural Variables Influencing Stereotactic Accuracy and Efficiency in Deep Brain Stimulation Surgery.

Oper Neurosurg (Hagerstown) 2018 Oct 18. Epub 2018 Oct 18.

Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona.

Background: Deep brain stimulation (DBS) is well-established, evidence-based therapy for Parkinson disease, essential tremor, and primary dystonia. Clinical outcome studies have recently shown that "asleep" DBS lead placement, performed using intraoperative imaging with stereotactic accuracy as the surgical endpoint, has motor outcomes comparable to traditional "awake" DBS using microelectrode recording (MER), but with shorter case times and improved speech fluency.

Objective: To identify procedural variables in DBS surgery associated with improved surgical efficiency and stereotactic accuracy. Read More

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https://academic.oup.com/ons/advance-article/doi/10.1093/ons
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http://dx.doi.org/10.1093/ons/opy291DOI Listing
October 2018
11 Reads

Outcomes from stereotactic surgery for essential tremor.

J Neurol Neurosurg Psychiatry 2018 Oct 18. Epub 2018 Oct 18.

Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada.

There are several different surgical procedures that are used to treat essential tremor (ET), including deep brain stimulation (DBS) and thalamotomy procedures with radiofrequency (RF), radiosurgery (RS) and most recently, focused ultrasound (FUS). Choosing a surgical treatment requires a careful presentation and discussion of the benefits and drawbacks of each. We conducted a literature review to compare the attributes and make an appraisal of these various procedures. Read More

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http://dx.doi.org/10.1136/jnnp-2018-318240DOI Listing
October 2018
6.807 Impact Factor

Thomas Mann and Neurology.

Front Neurol Neurosci 2018 18;43:76-84. Epub 2018 Oct 18.

Thomas Mann (1875-1955) is considered one of the most influential writers of the late nineteenth and early twentieth century. In addition to his novels and essays, he was well known for his criticisms of the Nazi party, and particularly against the racial nationalism promoted by Adolf Hitler after the First World War, as well as for his depiction of diseases. Here, we provide a quick sketch of Mann's life and his relationship with nineteenth to twentieth century German society. Read More

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http://dx.doi.org/10.1159/000490406DOI Listing
October 2018
2 Reads

[I]Ioflupane imaging in Caucasians and non-Caucasians: Are there any differences?

J Neurol Sci 2018 Dec 3;395:159-163. Epub 2018 Oct 3.

Division of Nuclear Medicine, Department of Radiology, University of Mississippi Medical Center, Jackson, MS, USA. Electronic address:

Purpose Of The Report: To compare diagnostic performance of [I]ioflupane SPECT imaging in different racial groups. In previous registration trials of [I]ioflupane, 99% of the subjects enrolled were Caucasians.

Materials And Methods: A multicenter retrospective case-control study was conducted to evaluate whether the diagnostic performance of [I]ioflupane SPECT imaging is different in non-Caucasians than in Caucasians matched by age, sex, and final clinical diagnosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0022510X183041
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http://dx.doi.org/10.1016/j.jns.2018.10.001DOI Listing
December 2018
6 Reads

Perampanel, a new hope for Essential tremor: An open label trial.

Parkinsonism Relat Disord 2018 Oct 9. Epub 2018 Oct 9.

Movement Disorders Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Catalonia, Spain.

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http://dx.doi.org/10.1016/j.parkreldis.2018.10.010DOI Listing
October 2018

Structural connectivity-based segmentation of the thalamus and prediction of tremor improvement following thalamic deep brain stimulation of the ventral intermediate nucleus.

Neuroimage Clin 2018 10;20:1266-1273. Epub 2018 Oct 10.

Department of Neurosurgery, University of Florida, Gainesville, FL, USA; Center of Neurology and Neurosurgery Associates (NeuroCENNA), BP-A Beneficência Portuguesa de São Paulo, São Paulo, Brazil.

Objectives: Traditional targeting methods for thalamic deep brain stimulation (DBS) performed to address tremor have predominantly relied on indirect atlas-based methods that focus on the ventral intermediate nucleus despite known variability in thalamic functional anatomy. Improvements in preoperative targeting may help maximize outcomes and reduce thalamic DBS-related complications. In this study, we evaluated the ability of thalamic parcellation with structural connectivity-based segmentation (SCBS) to predict tremor improvement following thalamic DBS. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22131582183031
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http://dx.doi.org/10.1016/j.nicl.2018.10.009DOI Listing
October 2018
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Absence of Mutation Enrichment for Genes Phylogenetically Conserved in the Olivocerebellar Motor Circuitry in a Cohort of Canadian Essential Tremor Cases.

Mol Neurobiol 2018 Oct 12. Epub 2018 Oct 12.

Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.

Essential Tremor is a prevalent neurological disorder of unknown etiology. Studies suggest that genetic factors contribute to this pathology. To date, no causative mutations in a gene have been reproducibly reported. Read More

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http://dx.doi.org/10.1007/s12035-018-1369-1DOI Listing
October 2018
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Focused Ultrasound Thalamotomy and Other Interventions for Medication-Refractory Essential Tremor: An Indirect Comparison of Short-Term Impact on Health-Related Quality of Life.

Value Health 2018 10 28;21(10):1168-1175. Epub 2018 Jun 28.

InSightec Ltd., Tirat Carmel, Israel.

Background: Up to 50% of essential tremor patients are refractory to medication and require alternative treatment to achieve tremor relief. This study aimed to identify and analyze evidence supporting the use of the emerging magnetic resonance-guided focused ultrasound (MRgFUS) compared to alternative stimulatory and ablative interventions for the treatment of medication-refractory essential tremor: radiofrequency thalamotomy, unilateral deep brain stimulation (DBS), and stereotactic radiosurgery.

Methods: A systematic literature review was conducted to identify clinical, health-related quality of life (HRQoL), and economic evidence for each intervention. Read More

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http://dx.doi.org/10.1016/j.jval.2018.03.015DOI Listing
October 2018
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Integrating Brain Implants With Local and Distributed Computing Devices: A Next Generation Epilepsy Management System.

IEEE J Transl Eng Health Med 2018 26;6:2500112. Epub 2018 Sep 26.

Mayo Systems Electrophysiology LaboratoryDepartment of NeurologyMayo ClinicRochesterMN55905USA.

Brain stimulation has emerged as an effective treatment for a wide range of neurological and psychiatric diseases. Parkinson's disease, epilepsy, and essential tremor have FDA indications for electrical brain stimulation using intracranially implanted electrodes. Interfacing implantable brain devices with local and cloud computing resources have the potential to improve electrical stimulation efficacy, disease tracking, and management. Read More

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https://ieeexplore.ieee.org/document/8458201/
Publisher Site
http://dx.doi.org/10.1109/JTEHM.2018.2869398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170139PMC
September 2018
2 Reads

Evaluating Mild Cognitive Impairment in Essential Tremor: How Many and Which Neuropsychological Tests?

J Int Neuropsychol Soc 2018 Nov 10;24(10):1084-1098. Epub 2018 Oct 10.

4Department of Neurology,College of Physicians and Surgeons,Columbia University,New York,New York.

Objectives: Essential tremor (ET) confers an increased risk for developing both amnestic and non-amnestic mild cognitive impairment (MCI). Yet, the optimal measures for detecting mild cognitive changes in individuals with this movement disorder have not been established. We sought to identify the cognitive domains and specific motor-free neuropsychological tests that are most sensitive to mild deficits in cognition as defined by a Clinical Dementia Rating (CDR) of 0. Read More

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https://www.cambridge.org/core/product/identifier/S135561771
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http://dx.doi.org/10.1017/S1355617718000747DOI Listing
November 2018
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Long-term effects of unilateral deep brain stimulation on voice tremor in patients with essential tremor.

Parkinsonism Relat Disord 2018 Sep 27. Epub 2018 Sep 27.

Department of Clinical Science, Umeå University, Sweden.

Introduction: Voice tremor (VT) is a common symptom of Essential tremor (ET). Deep brain stimulation (DBS) is an established treatment for ET overall, however, its effect on VT is less clear. The aim of this study was to evaluate long-term effects of DBS on VT and to investigate how VT symptoms develop over time in patients with ET. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2018.09.029DOI Listing
September 2018

The frequency and diagnostic accuracy of hand deformities in Parkinson's disease.

J Neural Transm (Vienna) 2018 Dec 5;125(12):1813-1817. Epub 2018 Oct 5.

New York Medical College, Valhalla, NY, USA.

Hand deformities are well-known abnormalities observed in patients with Parkinson's disease (PD). We determined the frequency and diagnostic accuracy of hand deformities in PD. We studied 44 consecutive patients with PD, 44 age- and gender-matched normal controls and 22 patients with essential tremor (ET). Read More

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http://dx.doi.org/10.1007/s00702-018-1937-6DOI Listing
December 2018
1 Read