4,097 results match your criteria Essential Tremor


Evaluation of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in essential tremor.

Ideggyogy Sz 2019 Jan;72(1-2):33-38

Bezmialem Vakif University Hospital, Department of Neurology, İstanbul, Turkey.

Background And Purpose: Although essential tremor (ET) is the most common cause of tremor, the pathology and underlying mechanisms have not fully understood yet. In addition to kinetic tremor, patients may present several types of tremor, gait ataxia, hearing deficits and eye movement abnormalities. Non-motor symptoms and signs have also added to definition of ET. Read More

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http://dx.doi.org/10.18071/https://doi.org/10.18071/isz.72.0033DOI Listing
January 2019

Correlation between fractional anisotropy changes in the targeted ventral intermediate nucleus and clinical outcome after transcranial MR-guided focused ultrasound thalamotomy for essential tremor: results of a pilot study.

J Neurosurg 2019 Feb 15:1-6. Epub 2019 Feb 15.

1Faculty of Advanced Techno-Surgery and.

OBJECTIVEThis study evaluated changes of fractional anisotropy (FA) in the ventral intermediate nucleus (VIM) of the thalamus after transcranial MR-guided focused ultrasound (TcMRgFUS) thalamotomy and their associations with clinical outcome.METHODSClinical and radiological data of 12 patients with medically refractory essential tremor (mean age 76.5 years) who underwent TcMRgFUS thalamotomy with VIM targeting were analyzed retrospectively. Read More

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http://dx.doi.org/10.3171/2018.10.JNS18993DOI Listing
February 2019
1 Read

Feasibility of Staged Bilateral Radiofrequency Vim Thalamotomy for Bilateral Essential Tremor.

World Neurosurg 2019 Feb 13. Epub 2019 Feb 13.

Tokyo Women's Medical University, Department of Neurosurgery, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 1628666 Japan, +813-3353-8112 (ext 28634). Electronic address:

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http://dx.doi.org/10.1016/j.wneu.2019.01.224DOI Listing
February 2019

Shorter pulse width reduces gait disturbances following deep brain stimulation for essential tremor.

J Neurol Neurosurg Psychiatry 2019 Feb 14. Epub 2019 Feb 14.

Charité - Universitätsmedizin Berlin, Department of Neurology, Movement Disorder and Neuromodulation Unit, Berlin, Germany

Objective: Gait disturbances are frequent side effects occurring during chronic thalamic deep brain stimulation (DBS) in patients with essential tremor (ET). Adapting stimulation settings to shorter pulse widths has been shown to reduce side effects of subthalamic DBS. Here, we assess how a reduction of pulse width changes gait performance of affected patients. Read More

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http://dx.doi.org/10.1136/jnnp-2018-319427DOI Listing
February 2019

A Smart Device System to Identify New Phenotypical Characteristics in Movement Disorders.

Front Neurol 2019 30;10:48. Epub 2019 Jan 30.

Institute of Medical Informatics, University of Münster, Münster, Germany.

Parkinson's disease and Essential Tremor are two of the most common movement disorders and are still associated with high rates of misdiagnosis. Collected data by technology-based objective measures (TOMs) has the potential to provide new promising and highly accurate movement data for a better understanding of phenotypical characteristics and diagnostic support. A technology-based system called Smart Device System (SDS) is going to be implemented for multi-modal high-resolution acceleration measurement of patients with PD or ET within a clinical setting. Read More

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http://dx.doi.org/10.3389/fneur.2019.00048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363699PMC
January 2019

Four-year follow-up results of magnetic resonance-guided focused ultrasound thalamotomy for essential tremor.

Mov Disord 2019 Feb 13. Epub 2019 Feb 13.

Department of Neurosurgery, Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea.

Background: Following the emergence of magnetic resonance-guided focused ultrasound as a promising tool for movement disorder surgery, thalamotomy for essential tremor using this technique has become a useful tool based on its efficacy and lack of adverse effects. Here, we summarize the 4-year results of previous reports focusing on the durability of effectiveness of magnetic resonance-guided focused ultrasound thalamotomy for essential tremor.

Methods: From October 2013 to August 2014, 15 patients with intractable essential tremor were enrolled. Read More

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http://dx.doi.org/10.1002/mds.27637DOI Listing
February 2019
5.680 Impact Factor

Factors Associated with Alzheimer's Disease: An Overview of Reviews.

J Prev Alzheimers Dis 2019 ;6(2):121-134

Michaël Rochoy, 20 rue André Pantigny, 62230 Outreau, France. +33667576735,

Alzheimer's disease (AD) is a frequent pathology, with a poor prognosis, for which no curative treatment is available in 2018. AD prevention is an important issue, and is an important research topic. In this manuscript, we have synthesized the literature reviews and meta-analyses relating to modifiable risk factors associated with AD. Read More

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http://dx.doi.org/10.14283/jpad.2019.7DOI Listing
January 2019

The 'SILENT Alarm': When History Taking Reveals a Potentially Fatal Toxicity.

Eur J Case Rep Intern Med 2018 26;5(6):000843. Epub 2018 Jun 26.

Internal Medicine 'T', Chaim Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel, affiliated to the Sackler School of Medicine, Tel-Aviv, Israel.

Introduction: The combination of acute/sub-acute neurological and metabolic derangements should always raise the suspicion of toxicity, either endogenous or exogenous. The adverse effects of psychiatric medications are especially difficult to determine since the psychiatric background of patients is often inaccessible.

Clinical Presentation: A 66-year-old man presented to the emergency department with dysarthria and uncontrolled tremor, rapidly deteriorating into a complex of severe neurological and metabolic derangements. Read More

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http://dx.doi.org/10.12890/2018_000843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346880PMC
June 2018
2 Reads

Flunarizine related movement disorders: a nationwide population-based study.

Sci Rep 2019 Feb 8;9(1):1705. Epub 2019 Feb 8.

Department of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung City, Taiwan.

Flunarizine (fz) causes side effects such as movement disorders (MDs). We investigated risk factors associated with fz-related MDs. Participants were recruited from the longitudinal health insurance databases and included patients who took fz for more than 1 month. Read More

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http://dx.doi.org/10.1038/s41598-018-37901-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368567PMC
February 2019
1 Read

Peripheral BDNF/TrkB protein expression is decreased in Parkinson's disease but not in Essential tremor.

J Clin Neurosci 2019 Feb 2. Epub 2019 Feb 2.

Department of Neurology, Changzhou No. 2 People's Hospital, The Affiliated Hospital of Nanjing Medical University, 29 Xinglong Alley, 213003 Changzhou, China.

BDNF-to-TrkB signaling pathways plays an important role in the long-term maintenance of the nigrostriatal system and that its deficiency may contribute to the onset and progression of Parkinson's disease (PD). To our knowledge this is the first study to investigate the expression of the brain-derived neurotrophic factor (BDNF) and phosphorylation status of TrkB in peripheral blood lymphocytes of 28 PD and 28 Essential tremor (ET) patients and 28 healthy controls using western blot analysis. Compared with controls, no significant difference of BDNF and total and phosphorylated TrkB levels were observed in ET, whereas BDNF and phosphorylated TrkB levels were significantly decreased in the PD groups (p < 0. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.01.017DOI Listing
February 2019
1 Read

Less Is More - Estimation of the Number of Strides Required to Assess Gait Variability in Spatially Confined Settings.

Front Aging Neurosci 2018 21;10:435. Epub 2019 Jan 21.

Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Neurocure Cluster of Excellence, Berlin, Germany.

Gait variability is an established marker of gait function that can be assessed using sensor-based approaches. In clinical settings, spatial constraints and patient condition impede the execution of longer distance walks for the recording of gait parameters. Turning paradigms are often used to overcome these constraints and commercial gait analysis systems algorithmically exclude turns for gait parameters calculations. Read More

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http://dx.doi.org/10.3389/fnagi.2018.00435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348278PMC
January 2019
1 Read

A retrospective evaluation of thalamic targeting for tremor deep brain stimulation using high-resolution anatomical imaging with supplementary fiber tractography.

J Neurol Sci 2019 Jan 16;398:148-156. Epub 2019 Jan 16.

Department of Neurosurgery, Fukuoka University, Faculty of Medicine, Fukuoka, Japan.

Objectives: Deep brain stimulation (DBS) of the ventral intermediate (Vim) thalamic nucleus is used to treat tremors. Here, we identified the Vim nucleus on fast gray matter acquisition T1 inversion recovery (FGATIR) images and delineated the dentate-rubrothalamic tract (DRT) to determine the DBS target. We evaluated whether this method could consistently identify the Vim nucleus by anatomical imaging and fiber tractography. Read More

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http://dx.doi.org/10.1016/j.jns.2019.01.025DOI Listing
January 2019

Yoga led by a physical therapist for individuals with Essential Tremor: An explorative pilot study.

Complement Ther Clin Pract 2019 Feb 19;34:17-22. Epub 2018 Oct 19.

Doctor of Physical Therapy Program, School of Movement and Rehabilitation Sciences, College of Health Professions, Bellarmine University, Louisville, KY, USA.

Purpose: The purpose of this pilot study is to evaluate the outcomes for individuals with Essential Tremor (ET) who participate in a community-based yoga class, led by a neurologic physical therapist.

Methods: Six subjects with ET completed an 8-week intervention consisting of weekly 1-h yoga classes (in the Vinyasa style) guided by an instructor (200-h registered yoga teacher, physical therapist, and neurological resident).

Results: Five subjects demonstrated improvements on the Tremor Research Group Essential Tremor Rating Scale (mean 15. Read More

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http://dx.doi.org/10.1016/j.ctcp.2018.10.010DOI Listing
February 2019

Botulinum toxin for the treatment of tremor.

Parkinsonism Relat Disord 2019 Jan 26. Epub 2019 Jan 26.

Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, TX, USA.

Tremor is a key clinical feature of several common neurological disorders. Adequate management of tremor has been an unmet need in clinical practice. Most of the anti-tremor medications have limited efficacy and are associated with undesirable adverse effects, especially in elderly patients. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2019.01.023DOI Listing
January 2019
1 Read

Controlling a motorized orthosis to follow elbow volitional movement: tests with individuals with pathological tremor.

J Neuroeng Rehabil 2019 Feb 1;16(1):23. Epub 2019 Feb 1.

Menrva Research Group, Schools of Mechatronic Systems Engineering and Engineering Science, Simon Fraser University, Burnaby, Canada.

Background: There is a need for alternative treatment options for tremor patients who do not respond well to medications or surgery, either due to side effects or poor efficacy, or that are excluded from surgery. The study aims to evaluate feasibility of a voluntary-driven, speed-controlled tremor rejection approach with individuals with pathological tremor. The suppression approach was investigated using a robotic orthosis for suppression of elbow tremor. Read More

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http://dx.doi.org/10.1186/s12984-019-0484-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359763PMC
February 2019
1 Read

Discrete Cosine Transform for the Analysis of Essential Tremor.

Front Physiol 2018 17;9:1947. Epub 2019 Jan 17.

Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom.

Essential tremor (ET) is the most common movement disorder. In fact, its prevalence is about 20 times higher than that of Parkinson's disease. In addition, studies have shown that a high percentage of cases, between 50 and 70%, are estimated to be of genetic origin. Read More

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http://dx.doi.org/10.3389/fphys.2018.01947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345195PMC
January 2019
1 Read

Essential Tremor.

Authors:
Stephen G Reich

Med Clin North Am 2019 Mar;103(2):351-356

Department of Neurology, University of Maryland School of Medicine, 110 South Paca Street, 3rd Floor, Baltimore, MD 21201, USA. Electronic address:

Essential tremor is one of the most common movement disorders. It is characterized by a bilateral action tremor of the upper limbs. It may be accompanied by tremor of the head, voice, or lower limbs. Read More

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http://dx.doi.org/10.1016/j.mcna.2018.10.016DOI Listing

An Acute Randomized Controlled Trial of Noninvasive Peripheral Nerve Stimulation in Essential Tremor.

Neuromodulation 2019 Jan 30. Epub 2019 Jan 30.

Department of Bioengineering, Stanford University, Stanford, CA, USA.

Objective: To evaluate the safety and effectiveness of a wrist-worn peripheral nerve stimulation device in patients with essential tremor (ET) in a single in-office session.

Methods: This was a randomized controlled study of 77 ET patients who received either treatment stimulation (N = 40) or sham stimulation (N = 37) on the wrist of the hand with more severe tremor. Tremor was evaluated before and immediately after the end of a single 40-minute stimulation session. Read More

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http://dx.doi.org/10.1111/ner.12930DOI Listing
January 2019

Phenotypic Variability of Essential Tremor Based on the Age at Onset.

Can J Neurol Sci 2019 Jan 28:1-7. Epub 2019 Jan 28.

Department of Neurology,National Institute of Mental Health and Neurosciences,Bangalore,India.

Background: Essential tremor (ET) is reported to have a bimodal distribution of age at onset (AAO) with phenotypic variability based on the AAO. This study aims to explore the distribution of AAO based on mathematical modeling and ascertain the differences, if any, in the clinical features of groups.

Methods: A chart review was conducted for 252 patients with ET diagnosed based on the Consensus statement of the Movement Disorder Society on Tremor. Read More

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http://dx.doi.org/10.1017/cjn.2018.384DOI Listing
January 2019
1.599 Impact Factor

Repeat magnetic resonance imaging-guided focused ultrasound thalamotomy for recurrent essential tremor: case report and review of MRI findings.

J Neurosurg 2019 Jan 25:1-6. Epub 2019 Jan 25.

Departments of1Radiology and.

An 86-year-old right-handed man with medically refractory essential tremor was treated using left-sided MRI-guided focused ultrasound (MRgFUS) thalamotomy targeting the dentatorubrothalamic tract (DRTT) at its intersection with the ventral intermediate nucleus of the thalamus, with immediate symptomatic improvement and immediate postprocedure imaging demonstrating disruption of the DRTT. The patient experienced a partial return of symptoms 9 weeks following the procedure, and MRI demonstrated retraction of the left thalamic ablation site. The patient underwent repeat left-sided MRgFUS thalamotomy 4 months after initial treatment, resulting in reduced tremor. Read More

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http://dx.doi.org/10.3171/2018.10.JNS181721DOI Listing
January 2019
1 Read

DaTQUANT: The Future of Diagnosing Parkinson's Disease.

J Nucl Med Technol 2019 Jan 25. Epub 2019 Jan 25.

GateWay Community College, United States.

Idiopathic Parkinson's disease (PD) is a progressive neurological condition which affects the dopamine transporters in the substantia nigra of the brain. Currently, over ten million people are living with this disease world-wide, with thousands of newly diagnosed and undiagnosed cases added every year. The disease is difficult to differentiate from other similar disorders, as symptoms widely vary and can mimic other conditions. Read More

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http://dx.doi.org/10.2967/jnmt.118.222349DOI Listing
January 2019
8 Reads

A Study on the Feasibility of the Deep Brain Stimulation (DBS) Electrode Localization Based on Scalp Electric Potential Recordings.

Front Physiol 2018 4;9:1788. Epub 2019 Jan 4.

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States.

Deep Brain Stimulation (DBS) is an effective therapy for patients disabling motor symptoms from Parkinson's disease, essential tremor, and other motor disorders. Precise, individualized placement of DBS electrodes is a key contributor to clinical outcomes following surgery. Electroencephalography (EEG) is widely used to identify the sources of intracerebral signals from the potential on the scalp. Read More

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http://dx.doi.org/10.3389/fphys.2018.01788DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328462PMC
January 2019
1 Read

A review of basal ganglia circuits and physiology: Application to deep brain stimulation.

Parkinsonism Relat Disord 2019 Jan 9. Epub 2019 Jan 9.

Department of Neuroscience, University of Florida, Gainesville, FL, USA; Department of Neurology, Fixel Center for Neurological Diseases, University of Florida, Gainesville, FL, USA.

Introduction: Drawing on the seminal work of DeLong, Albin, and Young, we have now entered an era of basal ganglia neuromodulation. Understanding, re-evaluating, and leveraging the lessons learned from neuromodulation will be crucial to facilitate an increased and improved application of neuromodulation in human disease.

Methods: We will focus on deep brain stimulation (DBS) - the most common form of basal ganglia neuromodulation - however, similar principles can apply to other neuromodulation modalities. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2019.01.009DOI Listing
January 2019
4 Reads
3.972 Impact Factor

Deep brain stimulation: potential for neuroprotection.

Ann Clin Transl Neurol 2019 Jan 8;6(1):174-185. Epub 2018 Nov 8.

Krembil Research Institute University Health Network Toronto Western Hospital Toronto Ontario Canada.

Over the last two decades there has been an exponential rise in the number of patients receiving deep brain stimulation (DBS) to manage debilitating neurological symptoms in conditions such as Parkinson's disease, essential tremor, and dystonia. Novel applications of DBS continue to emerge including treatment of various psychiatric conditions (e.g. Read More

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http://dx.doi.org/10.1002/acn3.682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331208PMC
January 2019
3 Reads

Essential tremor severity and anatomical changes in brain areas controlling movement sequencing.

Ann Clin Transl Neurol 2019 Jan 8;6(1):83-97. Epub 2018 Nov 8.

Neural and Cognitive Engineering group Centre for Automation and Robotics (CAR) CSIC-UPM Arganda del Rey Spain.

Objective: Although the cerebello-thalamo-cortical network has often been suggested to be of importance in the pathogenesis of essential tremor (ET), the origins of tremorgenic activity in this disease are not fully understood. We used a combination of cortical thickness imaging and neurophysiological studies to analyze whether the severity of tremor was associated with anatomical changes in the brain in ET patients

Methods: Magnetic resonance imaging (MRI) and a neurophysiological assessment were performed in 13 nondemented ET patients. High field structural brain MRI images acquired in a 3T scanner and analyses of cortical thickness and surface were carried out. Read More

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http://dx.doi.org/10.1002/acn3.681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331315PMC
January 2019
1 Read

Reply to: From beta-blockers to Parkinson's disease in respect of essential tremor.

Mov Disord 2019 Jan;34(1):154

Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel.

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http://dx.doi.org/10.1002/mds.27589DOI Listing
January 2019

From beta-blockers to Parkinson's disease in respect of essential tremor.

Mov Disord 2019 Jan;34(1):153

Department of Neurology, University of Ljubljana, Ljubljana, Slovenia.

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http://dx.doi.org/10.1002/mds.27586DOI Listing
January 2019

Reclassifying essential tremor: Implications for the future of past research.

Mov Disord 2019 Jan 17. Epub 2019 Jan 17.

Department of Neurology, National Institute of Mental Health & Neurosciences, Bangalore, India.

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http://dx.doi.org/10.1002/mds.27615DOI Listing
January 2019

[Genetics of movement disorders-rare but important].

Nervenarzt 2019 Feb;90(2):197-210

Klinik für Neurologie, Universitätsmedizin Essen, Hufelandstr. 55, 45147, Essen, Deutschland.

Rare genetic movement disorders are a heterogeneous group of diseases. The causes of many of these rare movement disorders could be resolved due to the progress in molecular genetic diagnostics. This led to a better pathophysiological characterization of rare movement disorders and also to the fact that many phenotypical overlaps could be found between different diseases. Read More

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http://dx.doi.org/10.1007/s00115-018-0659-1DOI Listing
February 2019
2 Reads

Merging the Pathophysiology and Pharmacotherapy of Tics.

Tremor Other Hyperkinet Mov (N Y) 2018 9;8:595. Epub 2019 Jan 9.

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Background: Anatomically, cortical-basal ganglia-thalamo-cortical (CBGTC) circuits have an essential role in the expression of tics. At the biochemical level, the proper conveyance of messages through these circuits requires several functionally integrated neurotransmitter systems. In this manuscript, evidence supporting proposed pathophysiological abnormalities, both anatomical and chemical is reviewed. Read More

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http://dx.doi.org/10.7916/D89C8F3CDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329776PMC
January 2019
1 Read

Essential Tremor and Parkinson's Disease: Exploring the Relationship.

Tremor Other Hyperkinet Mov (N Y) 2018 9;8:589. Epub 2019 Jan 9.

Parkinson's Disease Center and Movement Disorders Clinic, Baylor College of Medicine Houston, TX, USA.

Background: There is longstanding controversy surrounding the possible link between essential tremor (ET) and Parkinson's disease (PD). Inconsistent and unreliable diagnostic criteria may in part account for some of the difficulties in defining the relationship between these two common movement disorders.

Methods: References for this systematic review were identified using PubMed with the search terms "essential tremor" AND "Parkinson's disease" with articles published in English between 1960 and September 2018 included. Read More

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http://dx.doi.org/10.7916/D8MD0GVRDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329774PMC
January 2019
1 Read

Alternating Thalamic Deep Brain Stimulation for Essential Tremor: A Trial to Reduce Habituation.

Mov Disord Clin Pract 2018 Nov-Dec;5(6):620-626. Epub 2018 Nov 9.

Department of Neurology Oregon Health Sciences University Portland Oregon USA.

Background: DBS in the ventral intermediate nucleus (VIM) of the thalamus has been a revolutionary treatment for patients with essential tremor (ET) by reducing tremor. Unfortunately, some patients develop habituation to DBS and thus experience reduced efficacy and loss of tremor control. There are no standardized methods of addressing habituation to DBS. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/mdc3.12685
Publisher Site
http://dx.doi.org/10.1002/mdc3.12685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277363PMC
November 2018
3 Reads

Neurological Disorders in Central Spain, Second Survey: Feasibility Pilot Observational Study.

JMIR Res Protoc 2019 Jan 10;8(1):e10941. Epub 2019 Jan 10.

Department of Neurology, University Hospital "12 de Octubre", Madrid, Spain.

Background: The Neurological Disorders in Central Spain, second survey (NEDICES-2) is a population-based, closed-cohort study that will include over 8000 subjects aged ≥55 years. It will also include a biobank.

Objective: The objective of this study was to evaluate all major aspects of the NEDICES-2 (methods, database, screening instruments, and questionnaires, as well as interexpert rating of the neurological diagnoses) in each one of the planned areas (all of them in central Spain) and to test the possibility of obtaining biological samples from each participant. Read More

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http://www.researchprotocols.org/2019/1/e10941/
Publisher Site
http://dx.doi.org/10.2196/10941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329894PMC
January 2019
14 Reads

Magnetic Resonance-Guided Focused Ultrasound : Current Status and Future Perspectives in Thermal Ablation and Blood-Brain Barrier Opening.

J Korean Neurosurg Soc 2019 Jan 31;62(1):10-26. Epub 2018 Dec 31.

Toronto Western Research Institute, University Health Network, Toronto, Canada.

Magnetic resonance-guided focused ultrasound (MRgFUS) is an emerging new technology with considerable potential to treat various neurological diseases. With refinement of ultrasound transducer technology and integration with magnetic resonance imaging guidance, transcranial sonication of precise cerebral targets has become a therapeutic option. Intensity is a key determinant of ultrasound effects. Read More

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http://dx.doi.org/10.3340/jkns.2018.0180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328789PMC
January 2019

Magnetic Resonance-Guided High-Intensity Focused Ultrasound (MR-HIFU): Technical Background and Overview of Current Clinical Applications (Part 1).

Rofo 2019 Jan 10. Epub 2019 Jan 10.

Institute of Diagnostic and Interventional Radiology, University Hospital of Cologne, Germany.

Background:  Extracorporeal high-intensity focused ultrasound (HIFU) is a promising method for the noninvasive thermal ablation of benign and malignant tissue. Current HIFU treatments are performed under ultrasound (US-HIFU) or magnetic resonance (MR-HIFU) image guidance offering integrated therapy planning, real-time control (spatial and temperature guidance) and evaluation.

Methods:  This review is based on publications in peer-reviewed journals addressing thermal ablation using HIFU and includes our own clinical results as well. Read More

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http://dx.doi.org/10.1055/a-0817-5645DOI Listing
January 2019

Resistance, vulnerability and resilience: A review of the cognitive cerebellum in aging and neurodegenerative diseases.

Neurobiol Learn Mem 2019 Jan 7. Epub 2019 Jan 7.

University of Washington School of Medicine, Seattle, WA, United States. Electronic address:

In the context of neurodegeneration and aging, the cerebellum is an enigma. Genetic markers of cellular aging in cerebellum accumulate more slowly than in the rest of the brain, and it generates unknown factors that may slow or even reverse neurodegenerative pathology in animal models of Alzheimer's Disease (AD). Cerebellum shows increased activity in early AD and Parkinson's disease (PD), suggesting a compensatory function that may mitigate early symptoms of neurodegenerative pathophysiology. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10747427193000
Publisher Site
http://dx.doi.org/10.1016/j.nlm.2019.01.004DOI Listing
January 2019
9 Reads

The Roles of Age and Aging in Essential Tremor: An Epidemiological Perspective.

Authors:
Elan D Louis

Neuroepidemiology 2019 9;52(1-2):111-118. Epub 2019 Jan 9.

Division of Movement Disorders, Department of Neurology, Yale School of Medicine, Yale University, New Haven, Connecticut,

Background: With an aging population, it behooves physicians and scientists to gain an understanding of the intersections between aging and human disease. Here, the author reviews the intersections between age, aging, and essential tremor (ET), particularly as these relate to disease epidemiology.

Summary: The prevalence and incidence of ET both increase with age, and the former, in an exponential fashion with advanced aging. Read More

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https://www.karger.com/Article/FullText/492831
Publisher Site
http://dx.doi.org/10.1159/000492831DOI Listing
January 2019
1 Read

"Spooning": A Subtle Sign of Limb Dystonia.

Tremor Other Hyperkinet Mov (N Y) 2018 3;8:607. Epub 2018 Dec 3.

Department of Neurology, Yale School of Medicine, Yale University, New Haven, CT, USA.

Background: The diagnosis of dystonia can be clinically challenging due to its heterogeneous presentation; essential tremor (ET) is a more common neurological disorder, but may be mimicked by other movement disorders, including dystonia, leading to misdiagnosis.

Phenomenology Shown: In three patients with hand tremor, two with prior diagnoses of ET, we present examples of "spooning" of the hands, characterized by wrist flexion and metacarpophalangeal hyperextension.

Educational Value: Subtle dystonic features such as "spooning" may be present during the evaluation of patients with tremor and aid in the diagnosis of dystonia. Read More

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http://dx.doi.org/10.7916/D8B00NRVDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312906PMC
December 2018
1 Read

Beta2-Adrenoceptor Agonists in Parkinson's Disease and Other Synucleinopathies.

J Neuroimmune Pharmacol 2019 Jan 7. Epub 2019 Jan 7.

Movement Disorders Centre, Neurology Unit, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy.

Evidence supporting the use of β2AR agonists in synucleinopathies is rapidly growing. Findings come from different scientific approaches. Molecular and immunological data suggest that adrenergic stimulation may decrease both α-synuclein (α-syn) deposition and pro-inflammatory/neurotoxic molecules release. Read More

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http://dx.doi.org/10.1007/s11481-018-09831-0DOI Listing
January 2019

Toward Electrophysiology-Based Intelligent Adaptive Deep Brain Stimulation for Movement Disorders.

Neurotherapeutics 2019 Jan;16(1):105-118

Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.

Deep brain stimulation (DBS) represents one of the major clinical breakthroughs in the age of translational neuroscience. In 1987, Benabid and colleagues demonstrated that high-frequency stimulation can mimic the effects of ablative neurosurgery in Parkinson's disease (PD), while offering two key advantages to previous procedures: adjustability and reversibility. Deep brain stimulation is now an established therapeutic approach that robustly alleviates symptoms in patients with movement disorders, such as Parkinson's disease, essential tremor, and dystonia, who present with inadequate or adverse responses to medication. Read More

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http://dx.doi.org/10.1007/s13311-018-00705-0DOI Listing
January 2019
1 Read

Cortical Signal Suppression (CSS) for Detection of Subcortical Activity Using MEG and EEG.

Brain Topogr 2019 Mar 3;32(2):215-228. Epub 2019 Jan 3.

Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, 02129, USA.

Magnetoencephalography (MEG) and electroencephalography (EEG) use non-invasive sensors to detect neural currents. Since the contribution of superficial neural sources to the measured M/EEG signals are orders-of-magnitude stronger than the contribution of subcortical sources, most MEG and EEG studies have focused on cortical activity. Subcortical structures, however, are centrally involved in both healthy brain function as well as in many neurological disorders such as Alzheimer's disease and Parkinson's disease. Read More

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http://dx.doi.org/10.1007/s10548-018-00694-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374174PMC
March 2019
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Comparing deep brain stimulation in the ventral intermediate nucleus versus the posterior subthalamic area in essential tremor patients.

Surg Neurol Int 2018 4;9:244. Epub 2018 Dec 4.

Department of Neurosurgery, Maastricht University Medical Center, Maastricht, The Netherlands.

Background: The ventral intermediate nucleus (VIM) is the most commonly used target for deep brain stimulation (DBS) in patients with essential tremor (ET). Recent evidence suggests that the posterior subthalamic area (PSA) might be a better target for tremor reduction. We compared the outcome of VIM DBS with PSA DBS in our cohort of patients. Read More

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http://dx.doi.org/10.4103/sni.sni_234_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293600PMC
December 2018

A Quantitative Study of Empty Baskets in Essential Tremor and Other Motor Neurodegenerative Diseases.

J Neuropathol Exp Neurol 2019 Feb;78(2):113-122

Department of Chronic Disease Epidemiology, Yale School of Public Health, Yale University, New Haven, Connecticut; New York, New York; Albany, New York.

The underlying biology of essential tremor (ET) is poorly understood. Purkinje cell (PC) loss has been observed in some studies, although this finding remains somewhat controversial. Basket cells are interneurons whose axonal collaterals form a plexus around PC soma. Read More

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http://dx.doi.org/10.1093/jnen/nly114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330169PMC
February 2019
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Cost-Effectiveness of Magnetic Resonance-Guided Focused Ultrasound for Essential Tremor.

Mov Disord 2018 Dec 27. Epub 2018 Dec 27.

Health Quality Ontario, Toronto, Ontario, Canada.

Background: Radiofrequency thalamotomy and deep brain stimulation are current treatments for moderate to severe medication-refractory essential tremor. However, they are invasive and thus carry risks. Magnetic resonance-guided focused ultrasound is a new, less invasive surgical option. Read More

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http://doi.wiley.com/10.1002/mds.27587
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http://dx.doi.org/10.1002/mds.27587DOI Listing
December 2018
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Dexmedetomidine Sedation in Magnetic Resonance-Guided Focused Ultrasound Thalamotomy: A Case Series of 3 Patients.

A A Pract 2018 Dec 21. Epub 2018 Dec 21.

Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.

Magnetic resonance-guided focused ultrasound thalamotomy is an innovative minimally invasive treatment for medication-resistant tremor in patients with essential tremor and Parkinson disease. Sedation with common hypnotic agents is discouraged because the patient's cooperation is required during the procedure, and these drugs interact with the patient's tremor, interfering with the results of intraprocedural neurological evaluations. Dexmedetomidine may be the best choice for sedation during magnetic resonance-guided focused ultrasound thalamotomy, which can be prolonged and poorly tolerated by the awake patient. Read More

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http://dx.doi.org/10.1213/XAA.0000000000000946DOI Listing
December 2018
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The Effect of Octanoic Acid on Essential Voice Tremor: A Double-Blind, Placebo-Controlled Study.

Laryngoscope 2018 Dec 25. Epub 2018 Dec 25.

Department of Neurology, State University of New York Upstate Medical University, Syracuse, New York, U.S.A.

Objectives/hypothesis: The purpose of this study was to determine the effects of octanoic acid on acoustic, perceptual, and functional aspects of essential voice tremor (EVT).

Study Design: Prospective, double-blind, placebo-controlled, crossover study.

Methods: Sixteen participants with a diagnosis of EVT were randomized to a 3-week dosing condition of octanoic acid or placebo, followed by a 2-week washout period and crossover to the other condition for an additional 3 weeks. Read More

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http://dx.doi.org/10.1002/lary.27695DOI Listing
December 2018
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What Predicts Mortality in Essential Tremor? A Prospective, Longitudinal Study of Elders.

Front Neurol 2018 7;9:1077. Epub 2018 Dec 7.

Division of Movement Disorders, Department of Neurology, Yale School of Medicine, Yale University, New Haven, CT, United States.

Essential tremor (ET) is among the most common neurologic diseases. Although in the past it was considered a benign condition, recent research has demonstrated increased risk of mortality. To date, however, no studies have examined predictors of mortality in ET. Read More

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https://www.frontiersin.org/article/10.3389/fneur.2018.01077
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http://dx.doi.org/10.3389/fneur.2018.01077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292933PMC
December 2018
6 Reads

Revisiting the Clinical Phenomenology of "Cerebellar Tremor": Beyond the Intention Tremor.

Cerebellum 2018 Dec 18. Epub 2018 Dec 18.

Division of Movement Disorders, Department of Neurology, Yale School of Medicine, Yale University, New Haven, CT, USA.

Tremor is an involuntary, rhythmic, oscillatory movement of a body part. It is a central feature of a range of diseases resulting from pathological changes in the cerebellum. Interestingly, in modern times, the terms "cerebellar tremor" and "intention tremor" are often used synonymously and interchangeably. Read More

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http://link.springer.com/10.1007/s12311-018-0994-6
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http://dx.doi.org/10.1007/s12311-018-0994-6DOI Listing
December 2018
14 Reads

Correlation of proximal and distal muscle strength with upper limb functional ability in patients with essential tremor.

Acta Neurol Belg 2018 Dec 18. Epub 2018 Dec 18.

Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, SANKO University, İncilipınar Mah. Ali Fuat Cebesoy Bulvarı No: 45, 27090, Şehitkamil, Gaziantep, Turkey.

Despite being considered as a benign, genetic and monosymptomatic disorder, ET is a poorly understood entity with etiological and pathological heterogeneity. The aim of the present study was to examine the relation between proximal and distal muscle strength and upper limb functionality and tremor severity in patients with essential tremor (ET). The study enrolled 25 tremor patients followed at the neurology clinic of a university hospital and 19 healthy controls. Read More

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http://dx.doi.org/10.1007/s13760-018-01068-1DOI Listing
December 2018

Correction to: Cranial MR-guided Focused Ultrasound for Essential Tremor : Technical Considerations and Image Guidance.

Clin Neuroradiol 2018 Dec 14. Epub 2018 Dec 14.

Department of Neurosurgery, Weill Cornell Medicine, New York-Presbyterian Hospital, 525 East 68th Street, 10065, New York, NY, USA.

Correction to:Clin Neuroradiol 2018 https://doi.org/10.1007/s00062-018-0709-x The original version of this article unfortunately contained a mistake. Read More

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http://dx.doi.org/10.1007/s00062-018-0751-8DOI Listing
December 2018