4,534 results match your criteria Essential Tremor


Zonisamide-induced Choroidal Effusion: A Case Report.

J Glaucoma 2020 Jul 3. Epub 2020 Jul 3.

Hospital Universitari de Bellvitge.

Purpose: To describe a case of zonisamide-induced bilateral choroidal effusion.

Case Report: A 72-year-old woman presented with a 4-day history of bilateral blurred vision nine days after initiating oral zonisamide for essential tremor. Clinical examination revealed an asymmetric choroidal detachment with open anterior chamber angle and intraocular pressure within the normal range. Read More

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http://dx.doi.org/10.1097/IJG.0000000000001596DOI Listing

Remote telemedicine evaluation of deep brain stimulation candidacy: Retrospective cohort analysis.

Neurol Clin Pract 2020 Jun;10(3):199-205

Division of Movement Disorders (NW), Rush University Medical Center, Chicago, IL; EvergreenHealth for the Department of Neurosurgery (SLH), Kirkland, WA; and Department of Neurological Sciences (BO), Rush University Medical Center, Chicago, IL; San Francisco VA Medical Center (CMT, NBG), Parkinson's Disease Research, Education and Clinical Centers (PADRECC), CA; and Department of Neurology (CMT, NBG), University of California San Francisco (UCSF).

Objective: To determine whether initial presurgical evaluation of deep brain stimulation (DBS) candidacy with video telemedicine (VTEL) can reliably predict surgical candidacy (patients who will eventually undergo DBS surgery) and decrease resource utilization when compared to an in-person evaluation.

Methods: In this retrospective, cohort analysis, all out-of-state referrals to the San Francisco Veterans Affairs from 2008 to 2013 for DBS therapy were reviewed and their surgical outcomes were assessed until 2017. Patients were designated as good, borderline, or poor surgical candidates after initial evaluation, and their rates of undergoing DBS were recorded. Read More

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http://dx.doi.org/10.1212/CPJ.0000000000000723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292554PMC

Two-year Follow-up Results of Magnetic Resonance Imaging-guided Focused Ultrasound Unilateral Thalamotomy for Medication-refractory Essential Tremor.

Intern Med 2020 Jul 7. Epub 2020 Jul 7.

Department of Neurology, Shonan Fujisawa Tokushukai Hospital, Japan.

Objective To investigate the long-term efficacy and safety of magnetic resonance imaging-guided focused ultrasound (MRgFUS) unilateral ventral intermediate nucleus (Vim) thalamotomy for medication-refractory essential tremor (ET). Methods We performed MRgFUS left-sided Vim thalamotomy for 10 medication-refractory ET patients (8 men and 2 women, aged 67.1±17. Read More

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http://dx.doi.org/10.2169/internalmedicine.4360-19DOI Listing

Dysfunction of parvalbumin neurons in the cerebellar nuclei produces an action tremor.

J Clin Invest 2020 Jul 7. Epub 2020 Jul 7.

Department of Molecular and Cellular Physiology, Stanford University, Stanford, United States of America.

Essential tremor is a common brain disorder affecting millions of people, yet the neuronal mechanisms underlying this prevalent disease remain elusive. Here, we show that conditional deletion of synaptotagmin-2, the fastest Ca2+-sensor for synaptic neurotransmitter release, from parvalbumin neurons in mice causes an action tremor syndrome resembling the core symptom of essential tremor patients. Combining brain region-specific and cell type-specific genetic manipulation methods, we found that deletion of synaptotagmin-2 from excitatory parvalbumin-positive neurons in cerebellar nuclei was sufficient to generate an action tremor. Read More

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http://dx.doi.org/10.1172/JCI135802DOI Listing

Asleep Deep Brain Stimulation of the Nucleus Ventralis Intermedius for Essential Tremor Using Indirect Targeting and Interventional Magnetic Resonance Imaging: Single-Institution Case Series.

Mov Disord Clin Pract 2020 Jul 27;7(5):521-530. Epub 2020 Apr 27.

Department of Neurosurgery University of Arizona College of Medicine Tucson Arizona USA.

Background: Literature on asleep deep brain stimulation (DBS) of the ventralis intermedius (Vim) nucleus in essential tremor is relatively sparse. Furthermore, controversy exists as to whether indirect ("consensus" or "atlas-based") targeting of the Vim requires physiologic adjustment for effective clinical outcomes in DBS surgery.

Objectives: The objective of this study was to evaluate the clinical results of asleep Vim DBS using indirect coordinates and real-time interventional magnetic resonance imaging guidance. Read More

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http://dx.doi.org/10.1002/mdc3.12955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328410PMC

Movement during focused ultrasound therapy caused by an unstable magnetic resonance table: case report.

J Neurosurg 2020 Jul 3:1-4. Epub 2020 Jul 3.

1Department of Neurosurgery, Tokyo Women's Medical University, Tokyo.

Transcranial MR-guided focused ultrasound (MRgFUS) therapy is a less invasive form of stereotactic treatment for tremors and other movement disorders. Its stereotactic accuracy is ensured by stability of the stereotactic frame and MR table. The authors report a case wherein the patient's movement was detected, and the MR images were repeated to continue the treatment. Read More

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http://dx.doi.org/10.3171/2020.4.JNS20219DOI Listing

Clinical applications of neurochemical and electrophysiological measurements for closed-loop neurostimulation.

Neurosurg Focus 2020 Jul;49(1):E6

1Department of Neurologic Surgery.

The development of closed-loop deep brain stimulation (DBS) systems represents a significant opportunity for innovation in the clinical application of neurostimulation therapies. Despite the highly dynamic nature of neurological diseases, open-loop DBS applications are incapable of modifying parameters in real time to react to fluctuations in disease states. Thus, current practice for the designation of stimulation parameters, such as duration, amplitude, and pulse frequency, is an algorithmic process. Read More

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http://dx.doi.org/10.3171/2020.4.FOCUS20167DOI Listing

MRI and tractography techniques to localize the ventral intermediate nucleus and dentatorubrothalamic tract for deep brain stimulation and MR-guided focused ultrasound: a narrative review and update.

Neurosurg Focus 2020 Jul;49(1):E8

Departments of1Radiology.

The thalamic ventral intermediate nucleus (VIM) can be targeted for treatment of tremor by several procedures, including deep brain stimulation (DBS) and, more recently, MR-guided focused ultrasound (MRgFUS). To date, such targeting has relied predominantly on coordinate-based or atlas-based techniques rather than directly targeting the VIM based on imaging features. While general regional differences of features within the thalamus and some related white matter tracts can be distinguished with conventional imaging techniques, internal nuclei such as the VIM are not discretely visualized. Read More

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http://dx.doi.org/10.3171/2020.4.FOCUS20170DOI Listing

A systematic review of impairment focussed technology in neurology.

Disabil Rehabil Assist Technol 2020 Jul 1:1-14. Epub 2020 Jul 1.

University of Copenhagen, Denmark.

We provide an overview of some biomedical technologies able to relieve everyday impairments in neurological patients. Two literature searches from 2009 to 2020 were conducted using PubMed, Embase, Cinahl and Scopus. The studies meeting the criteria for eligibility constituted 224 of the 6257 identified studies. Read More

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http://dx.doi.org/10.1080/17483107.2020.1776776DOI Listing

Is an Isolated Weight-Holding Tremor a New Subtype of Isometric Tremor?

Yonsei Med J 2020 Jul;61(7):644-646

Department of Neurology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.

A weight-holding tremor is a rare type of hand tremor that occurs only when someone holds some weight. Here we report three cases of isolated weight-holding tremors, of which one patient was diagnosed with Parkinson's disease (PD) and the others as a variant of essential tremor (ET). A 68-year-old woman presented with a left-hand tremor that appeared only when she held objects with some weight. Read More

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http://dx.doi.org/10.3349/ymj.2020.61.7.644DOI Listing

A pilot study of essential tremor: cerebellar GABA+/Glx ratio is correlated with tremor severity.

Cerebellum Ataxias 2020 26;7. Epub 2020 Jun 26.

Department of Neurosurgery and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.

Objective: Essential tremor is a common movement disorder with an unclear origin. Emerging evidence suggests the role of the cerebellum and the thalamus in tremor pathophysiology. We examined the two main neurotransmitters acting inhibitory (GABA+) and excitatory (Glx) respectively, in the thalamus and cerebellum, in patients diagnosed with severe essential tremor. Read More

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http://dx.doi.org/10.1186/s40673-020-00116-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318770PMC

A Wearable System for Attenuating Essential Tremor Based on Peripheral Nerve Stimulation.

IEEE J Transl Eng Health Med 2020 6;8:2000111. Epub 2020 Apr 6.

School of Electrical and Computer EngineeringGeorgia Institute of TechnologyAtlantaGA30332USA.

Objective: Currently available treatments for kinetic tremor can cause intolerable side effects or be highly invasive and expensive. Even though several studies have shown the positive effects of external feedback (i.e. Read More

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http://dx.doi.org/10.1109/JTEHM.2020.2985058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313727PMC

Motion-flow-guided recurrent network for respiratory signal estimation of x-ray angiographic image sequences.

Phys Med Biol 2020 Jun 26. Epub 2020 Jun 26.

School of Optics and Photonics, Beijing Institute of Technology, NO.5 Zhongguancun south street, Beijing, 100081, CHINA.

Motion compensation can eliminate the inconsistency of respiratory and cardiac phases during image acquisitions for precise vascular reconstruction in the clinical diagnosis of vascular disease from X-ray angiographic image sequences. In X-ray-based vascular interventional therapy, motion modeling can simulate the process of organ deformation driven by motion signals to display a dynamic organ on angiograms without contrast agent injection. Automatic respiratory signal estimation from X-ray angiographic image sequences is essential for motion compensation and modeling. Read More

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http://dx.doi.org/10.1088/1361-6560/aba087DOI Listing

Synchrony drives motor cortex β bursting, waveform dynamics and phase-amplitude coupling in Parkinson disease.

J Neurosci 2020 Jun 23. Epub 2020 Jun 23.

Neuroscience Interdepartmental Program, University of California, Los Angeles, USA.

Several lines of inquiry have separately identified β oscillations, synchrony, waveform shape and phase-amplitude coupling as important but sometimes inconsistent factors in the pathophysiology of Parkinson disease. What has so far been lacking is a means by which these neurophysiological parameters are interrelated and how they relate to clinical symptomatology. To clarify the relationship between oscillatory power, bursting, synchrony and phase-amplitude coupling, we recorded local field potentials/electrocorticography from hand motor and premotor cortical area in human subjects with essential tremor (N = 10) and Parkinson disease (N = 22) during deep brain stimulator implantation surgery (14 females, 18 males). Read More

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http://dx.doi.org/10.1523/JNEUROSCI.1996-19.2020DOI Listing

Fragile X-Associated Tremor/Ataxia Syndrome (FXTAS): Pathophysiology and Clinical Implications.

Int J Mol Sci 2020 Jun 20;21(12). Epub 2020 Jun 20.

UC Davis MIND Institute, UC Davis Health, Sacramento, CA 95817, USA.

The fragile X-associated tremor/ataxia syndrome (FXTAS) is a neurodegenerative disorder seen in older premutation (55-200 CGG repeats) carriers of The premutation has excessive levels of mRNA that lead to toxicity and mitochondrial dysfunction. The clinical features usually begin in the 60 s with an action or intention tremor followed by cerebellar ataxia, although 20% have only ataxia. MRI features include brain atrophy and white matter disease, especially in the middle cerebellar peduncles, periventricular areas, and splenium of the corpus callosum. Read More

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http://dx.doi.org/10.3390/ijms21124391DOI Listing

The Smart Device System for Movement Disorders: Preliminary Evaluation of Diagnostic Accuracy in a Prospective Study.

Stud Health Technol Inform 2020 Jun;270:889-893

Department of Neurology, University Hospital of Münster, Germany.

Consumer wearables can provide objective monitoring of movement disorders and may identify new phenotypical biomarkers. We present a novel smartwatch-based prototype, which is implemented as a prospective study in neurology. A full-stack Machine Learning pipeline utilizing Artificial Neural Networks (ANN), Random Forests and Support Vector Machines (SVM) was established and optimized to train for two clinically relevant classification tasks: First, to distinguish neurodegenerative movement disorders such as Parkinson's Disease (PD) or Essential Tremor from healthy subjects. Read More

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http://dx.doi.org/10.3233/SHTI200289DOI Listing

Maximizing placebo response in neurological clinical practice.

Int Rev Neurobiol 2020 9;153:71-101. Epub 2020 Jun 9.

Department of Neurology, Pitié-Salpêtrière Hospital, Sorbonne University, Assistance Publique Hôpitaux de Paris, Brain and Spine Institute, ICM, Inserm U 1127, CNRS UMR 7225, Paris, France. Electronic address:

The placebo effect is a widely recognized phenomenon in clinical research, with a negative perception that it could hide the "true" drug effect. In clinical care its positive potential to increase known drug effects has been neglected for too long. The placebo and nocebo responses have been described in many neurologic disorders such as Parkinson's, Huntington's and Alzheimer's diseases, restless leg syndrome, tics, essential tremor, dystonia, functional movement disorders, neuropathic pain, headaches, migraine, amyotrophic lateral sclerosis, myasthenia gravis, chronic inflammatory demyelinating polyneuropathy, multiple sclerosis and epilepsy. Read More

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http://dx.doi.org/10.1016/bs.irn.2020.04.003DOI Listing

Diagnostic Delay in Cervical Dystonia: Dystonia with Antecedent Essential Tremor?

Mov Disord 2020 Jun;35(6):1085-1086

Department of Neurology, Govind Ballabh Pant Postgraduate Institute of Medical Education and Research, New Delhi, India.

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http://dx.doi.org/10.1002/mds.28103DOI Listing

Brain TRODAT-SPECT Versus MRI Morphometry in Distinguishing Early Mild Parkinson's Disease from Other Extrapyramidal Syndromes.

J Neuroimaging 2020 Jun 17. Epub 2020 Jun 17.

Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Background And Purpose: The clinical differentiation of Parkinson's disease (PD) from other extrapyramidal syndromes has made a challenge in neurology. This study aimed to compare the specificity and sensitivity of brain MRI volumetry and dopamine transporter scans in differentiating PD from other extrapyramidal syndromes in the early stages of the disease.

Methods: This study included 34 patients younger than 70 years old with less than 3 years of extrapyramidal symptoms. Read More

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http://dx.doi.org/10.1111/jon.12740DOI Listing

Effect of thalamic deep brain stimulation on swallowing in patients with essential tremor.

Ann Clin Transl Neurol 2020 Jun 16. Epub 2020 Jun 16.

Department of Neurology, University Hospital Muenster, Muenster, Germany.

Objective: Deep brain stimulation (DBS) of the ventral intermediate nucleus (VIM) is a mainstay treatment for severe and drug-refractory essential tremor (ET). Although stimulation-induced dysarthria has been extensively described, possible impairment of swallowing has not been systematically investigated yet.

Methods: Twelve patients with ET and bilateral VIM-DBS with self-reported dysphagia after VIM-DBS were included. Read More

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http://dx.doi.org/10.1002/acn3.51099DOI Listing

Optimal Parameters of Deep Brain Stimulation in Essential Tremor: A Meta-Analysis and Novel Programming Strategy.

J Clin Med 2020 Jun 14;9(6). Epub 2020 Jun 14.

Department of Neurology, Amsterdam Neuroscience Institute, Amsterdam University Medical Center, 1007 MB Amsterdam, The Netherlands.

The programming of deep brain stimulation (DBS) parameters for tremor is laborious and empirical. Despite extensive efforts, the end-result is often suboptimal. One reason for this is the poorly understood relationship between the stimulation parameters' voltage, pulse width, and frequency. Read More

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http://dx.doi.org/10.3390/jcm9061855DOI Listing

Advanced MRI techniques for transcranial high intensity focused ultrasound targeting.

Brain 2020 Jun 15. Epub 2020 Jun 15.

Department of Radiology, University of Texas Southwestern, Dallas, TX 75390, USA.

Magnetic resonance guided high intensity focused ultrasound is a novel, non-invasive, image-guided procedure that is able to ablate intracranial tissue with submillimetre precision. It is currently FDA approved for essential tremor and tremor dominant Parkinson's disease. The aim of this update is to review the limitations of current landmark-based targeting techniques of the ventral intermediate nucleus and demonstrate the role of emerging imaging techniques that are relevant for both magnetic resonance guided high intensity focused ultrasound and deep brain stimulation. Read More

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http://dx.doi.org/10.1093/brain/awaa107DOI Listing

Tick-Tock on the Ward: Essential Palatal Tremor in a Pediatric Patient.

J Pediatr 2020 Jun 6. Epub 2020 Jun 6.

Department of Neurology and Clinical Neurophysiology, Children's Health Ireland at Temple Street, Dublin, Ireland; School of Medicine and Medical Science, University College Dublin, Dublin, Ireland.

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http://dx.doi.org/10.1016/j.jpeds.2020.05.061DOI Listing

Tremor pathophysiology: lessons from neuroimaging.

Curr Opin Neurol 2020 06 8. Epub 2020 Jun 8.

Center of Expertise for Parkinson & Movement Disorders, Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands.

Purpose Of Review: We discuss the latest neuroimaging studies investigating the pathophysiology of Parkinson's tremor, essential tremor, dystonic tremor and Holmes tremor.

Recent Findings: Parkinson's tremor is associated with increased activity in the cerebello-thalamo-cortical circuit, with interindividual differences depending on the clinical dopamine response of the tremor. Although dopamine-resistant Parkinson's tremor arises from a larger contribution of the (dopamine-insensitive) cerebellum, dopamine-responsive tremor may be explained by thalamic dopamine depletion. Read More

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http://dx.doi.org/10.1097/WCO.0000000000000829DOI Listing

GGC repeat expansion in NOTCH2NLC is rare in European patients with essential tremor.

Brain 2020 Jun 9. Epub 2020 Jun 9.

Department of Neuromuscular Diseases, Institute of Neurology, University College London, UK.

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http://dx.doi.org/10.1093/brain/awaa144DOI Listing

Swimming with Cerebellar Ataxia.

PM R 2020 Jun 9. Epub 2020 Jun 9.

Department of Neurology, Columbia University Medical Center, New York, NY, USA.

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http://dx.doi.org/10.1002/pmrj.12431DOI Listing

Evidence of central involvement in essential tremor: a detailed study of auditory pathway physiology.

J Neural Transm (Vienna) 2020 Aug 7;127(8):1153-1159. Epub 2020 Jun 7.

Division of Movement Disorders, Department of Neurology, Yale School of Medicine, Yale University, New Haven, CT, USA.

Essential tremor (ET) is a common tremor disorder that is likely neurodegenerative. The pathophysiology of ET involves the cerebellum and its connections in the brainstem and thalamus. Hearing dysfunction has been shown to be a non-motor finding in ET patients. Read More

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http://dx.doi.org/10.1007/s00702-020-02215-wDOI Listing
August 2020
2.402 Impact Factor

Involvement of NMDA receptors in tremor expression in Aspa/Hcn1 double-knockout rats.

Exp Anim 2020 Jun 5. Epub 2020 Jun 5.

Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University.

We recently demonstrated that aspartoacylase (Aspa) and hyperpolarized-activated cyclic nucleotide-gated potassium channel 1 (Hcn1) genes were causative of essential tremor (ET) in rats. This finding was obtained using Aspa/Hcn1 double-mutant rats, but they were bred on a heterogeneous genetic background of two strains, F344 and WTC. Here, we developed an Aspa/Hcn1 double-knockout rat strain with a homogenous F344 genetic background and studied the ability of glutamate receptor antagonists to suppress ET. Read More

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http://dx.doi.org/10.1538/expanim.20-0025DOI Listing

NOTCH2NLC GGC repeat expansions are associated with sporadic essential tremor: Variable disease expressivity on long-term follow-up.

Ann Neurol 2020 Jun 4. Epub 2020 Jun 4.

Neuroscience and Behavioural Disorders, Duke NUS Medical School, Singapore.

We screened 662 subjects comprising 462 essential tremor, ET (285 sporadic, 125 with family history and 52 probands from well-characterized ET pedigrees and 200 controls and identified pathogenic NOTCH2NLC GGC repeat expansions in four sporadic ET patients. Two patients were followed up for over a decade: one with 90 repeats remained an ET phenotype that did not evolve after forty years, while another patient with 107 repeats developed motor symptoms and cognitive impairment after 8 to 10years. Neuroimaging in this patient revealed severe leukoencephalopathy; diffusion-weighted imaging hyperintensity in the corticomedullary junction and skin biopsy revealed intranuclear inclusions suggestive of intranuclear inclusion body disease (NIID). Read More

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http://dx.doi.org/10.1002/ana.25803DOI Listing
June 2020
9.977 Impact Factor

Deep Brain Stimulation Lead Implantation Using a Customized Rapidly Manufactured Stereotactic Fixture with Submillimetric Euclidean Accuracy.

Stereotact Funct Neurosurg 2020 Jun 2:1-8. Epub 2020 Jun 2.

Department of Neurosurgery, University of Louisville School of Medicine, Louisville, Kentucky, USA,

Background: The microTargetingTM MicrotableTM Platform is a novel stereotactic system that can be more rapidly fabricated than currently available 3D-printed alternatives. We present the first case series of patients who underwent deep brain stimulation (DBS) surgery guided by this platform and demonstrate its in vivo accuracy.

Methods: Ten patients underwent DBS at a single institution by the senior author and 15 leads were placed. Read More

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http://dx.doi.org/10.1159/000506959DOI Listing

Long-term efficacy and cognitive effects of voltage-based deep brain stimulation for drug-resistant essential tremor.

Clin Neurol Neurosurg 2020 Jul 24;194:105940. Epub 2020 May 24.

Department of Neurosurgery, SanBo Brain Hospital, Capital Medical University, Beijing 100093, China; Beijing Key Laboratory of Epilepsy, Beijing 100093, China; Center of Epilepsy, Beijing Institute for Brain Disorders, Beijing 100093, China. Electronic address:

Objectives: To analyze the long-term efficacy and cognitive effects of voltage-based deep brain stimulation (DBS) for drug-resistant essential tremor (ET).

Patients And Methods: Patients with drug-resistant ET and treated by voltage-based DBS of the ventral intermediate nucleus (VIM-DBS) were continuously enrolled. Seizure outcomes were assessed by blinded observers using the Tremor Rating Scale (TRS). Read More

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http://dx.doi.org/10.1016/j.clineuro.2020.105940DOI Listing

Trends in safety and cost of deep brain stimulation for treatment of movement disorders in the United States: 2002-2014.

Br J Neurosurg 2020 Jun 1:1-8. Epub 2020 Jun 1.

Department of Neurological Surgery, University of California, San Francisco, CA, USA.

Deep brain stimulation (DBS) is being increasingly utilized to treat movement disorders including Parkinson's disease (PD), essential tremor (ET), and dystonia. An improved understanding of national trends in safety and cost is necessary. Herein, our objectives are to (1) characterize complication, mortality, and cost profiles of patients undergoing DBS for movement disorders in the United States, (2) identify predictors of morbidity and mortality, and (3) evaluate impact of complications on cost. Read More

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http://dx.doi.org/10.1080/02688697.2020.1759776DOI Listing
June 2020
0.947 Impact Factor

Non-motor symptoms are associated with midline tremor in essential tremor.

Acta Neurol Scand 2020 Jun 1. Epub 2020 Jun 1.

Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.

Objectives: Essential tremor (ET) patients presenting tremor in the midline structures may be a distinct subtype of the syndrome. Therefore, we sought to explore the clinical manifestations, especially non-motor symptoms (NMS) of Chinese ET patients with midline tremor (MT).

Methods: In the cross-sectional study, we grouped 290 definite or probable ET patients based on their MT conditions. Read More

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http://dx.doi.org/10.1111/ane.13290DOI Listing

Essential tremor as the early symptom of NOTCH2NLC gene-related repeat expansion disorder.

Brain 2020 May 25. Epub 2020 May 25.

Department of Neurology, the First Affiliated Hospital of Soochow University, Suzhou, 215000, China.

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http://dx.doi.org/10.1093/brain/awaa142DOI Listing

Essential tremor vs idiopathic Parkinson disease: Utility of transcranial sonography.

Medicine (Baltimore) 2020 May;99(20):e20028

Department of Medical Ultrasound.

Substantia nigra (SN) hyperechogenicity measured by transcranial sonography (TCS) is a promising biomarker for Parkinson disease (PD). The aim of this study was to explore the diagnostic accuracy of SN hyperechogenicity (SN) for differentiating PD from essential tremor (ET). A total of 119 patients with PD, 106 ET patients and 112 healthy controls that underwent TCS from November 2016 to February 2019 were included in this single-center retrospective case-control study. Read More

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http://dx.doi.org/10.1097/MD.0000000000020028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254097PMC

Effects of implantation of a deep brain stimulation device on patient weight in Parkinson's disease and essential tremor.

J Neurosurg 2020 May 22:1-7. Epub 2020 May 22.

3Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona.

Objective: Deep brain stimulation (DBS) is a well-established therapy for treating neurological movement disorders. Some patients who have received DBS therapy have noticed significant weight gain. Further investigation into correlations between patient characteristics and weight gain following DBS device implantation, which the authors here have done, will provide physicians with useful clinical information. Read More

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http://dx.doi.org/10.3171/2020.2.JNS192354DOI Listing

Individualized Anatomy-Based Targeting for VIM-cZI DBS in Essential Tremor.

World Neurosurg 2020 May 11. Epub 2020 May 11.

Department of Neurological Surgery, University of Miami, Miami, Florida, USA. Electronic address:

Background: Deep brain stimulation of the ventral intermediate nucleus (VIM) or caudal zona incerta (cZI) is effective for refractory essential tremor (ET). To refine stereotactic planning for lead placement, we developed a unique individualized anatomy-based planning protocol that targets both the VIM and the cZI in patients with ET.

Methods: 33 patients with ET underwent VIM-cZI lead implantation with targeting based on our protocol. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.04.240DOI Listing

Primary orthostatic tremor in mandible: A rare case report.

Indian J Dent Res 2020 Mar-Apr;31(2):315-317

Department of Dentistry, University of Pernambuco, Recife; Department of Prosthodontics, Bauru School of Dentistry, University of São Paulo, Bauru, Brazil.

Primary orthostatic tremor (POT) is a rare movement disorder of unknown pathophysiology, characterized by fast tremor affecting a specific part of the body. The present paper reports a case of POT in mandible, discussing the approach and management. A 37-year-old male patient complained of involuntary mandibular movements, with onset 6 years ago, with no history of precipitating event. Read More

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http://dx.doi.org/10.4103/ijdr.IJDR_933_18DOI Listing

Over the Horizon: The Present and Future of Endovascular Neural Recording and Stimulation.

Front Neurosci 2020 6;14:432. Epub 2020 May 6.

Department of Neurology, UTHealth McGovern Medical School, Houston, TX, United States.

The past decade has witnessed an explosion in applications for neural recording and stimulation in the treatment of clinical disorders. Neuromodulatory approaches are now a mainstay of care for essential tremor and Parkinson's disease, and are expanding rapidly into a wide range of other neurological and psychiatric diseases. In parallel, advancements in endovascular approaches to cerebrovascular diseases have resulted in minimally invasive techniques that deliver devices to neural tissue in the central and peripheral nervous systems, with significantly improved safety and efficacy. Read More

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http://dx.doi.org/10.3389/fnins.2020.00432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218134PMC

Quantitative Separation of Tremor and Ataxia in Essential Tremor.

Ann Neurol 2020 May 17. Epub 2020 May 17.

Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA.

Objective: This study addresses an important problem in neurology, distinguishing tremor and ataxia using quantitative methods. Specifically, we aimed to quantitatively separate dysmetria, a cardinal sign of ataxia, from tremor in essential tremor (ET).

Methods: In Experiment 1, we compared 19 participants diagnosed with ET undergoing thalamic deep brain stimulation (DBS; ET ) to 19 healthy controls (HC). Read More

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http://dx.doi.org/10.1002/ana.25781DOI Listing

Unravelling the enigma of cortical tremor and other forms of cortical myoclonus.

Brain 2020 May 17. Epub 2020 May 17.

Department of Clinical and Movement Neurosciences, Queen Square Institute of Neurology, University College London, London, UK.

Cortical tremor is a fine rhythmic oscillation involving distal upper limbs, linked to increased sensorimotor cortex excitability, as seen in cortical myoclonus. Cortical tremor is the hallmark feature of autosomal dominant familial cortical myoclonic tremor and epilepsy (FCMTE), a syndrome not yet officially recognized and characterized by clinical and genetic heterogeneity. Non-coding repeat expansions in different genes have been recently recognized to play an essential role in its pathogenesis. Read More

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http://dx.doi.org/10.1093/brain/awaa129DOI Listing

Human brain connectivity: Clinical applications for clinical neurophysiology.

Clin Neurophysiol 2020 Jul 21;131(7):1621-1651. Epub 2020 Apr 21.

Department of Neuroscience and Neurorehabilitation, Brain Connectivity Laboratory, IRCCS San Raffaele Pisana, Rome, Italy.

This manuscript is the second part of a two-part description of the current status of understanding of the network function of the brain in health and disease. We start with the concept that brain function can be understood only by understanding its networks, how and why information flows in the brain. The first manuscript dealt with methods for network analysis, and the current manuscript focuses on the use of these methods to understand a wide variety of neurological and psychiatric disorders. Read More

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http://dx.doi.org/10.1016/j.clinph.2020.03.031DOI Listing
July 2020
3.097 Impact Factor

Advanced Imaging and Direct Targeting of the Motor Thalamus and Dentato-Rubro-Thalamic Tract for Tremor: A Systematic Review.

Stereotact Funct Neurosurg 2020 May 13:1-21. Epub 2020 May 13.

Department of Neurosurgery, University of Arizona College of Medicine, Tucson, Arizona, USA,

Direct targeting methods for stereotactic neurosurgery in the treatment of essential tremor have been the subject of active research over the past decade but have not yet been systematically reviewed. We present a clinically oriented topic review based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses Group guidelines. Our focus is studies using advanced magnetic resonance imaging (MRI) techniques (ultrahigh-field structural MRI, diffusion-weighted imaging, diffusion-tensor tractography, and functional MRI) for patient specific, in vivo identification of the ventral intermediate nucleus and the dentato-rubro-thalamic tract. Read More

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http://dx.doi.org/10.1159/000507030DOI Listing

Focused Ultrasound Thalamotomy with Dentato-Rubro-Thalamic Tractography in Patients with Spinal Cord Stimulators and Cardiac Pacemakers.

Stereotact Funct Neurosurg 2020 May 13:1-7. Epub 2020 May 13.

Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Magnetic resonance image-guided high-intensity focused ultrasound (MRgFUS)-based thermal ablation of the ventral intermediate nucleus of the thalamus (VIM) is a minimally invasive treatment modality for essential tremor (ET). Dentato-rubro-thalamic tractography (DRTT) is becoming increasingly popular for direct targeting of the presumed VIM ablation focus. It is currently unclear if patients with implanted pulse generators (IPGs) can safely undergo MRgFUS ablation and reliably acquire DRTT suitable for direct targeting. Read More

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http://dx.doi.org/10.1159/000507031DOI Listing

Quality improvement in neurology: Neurology Outcomes Quality Measurement Set.

Neurology 2020 Jun 12;94(22):982-990. Epub 2020 May 12.

From the Departments of Neurology (J.J.S.), Internal Medicine, and the Center for NeuroEpidemiological and Clinical Neurological Research, Yale School of Medicine, New Haven, CT; and Neurology Service and Pain Research, Informatics, Multi-morbidities, and Education (PRIME) Health Services Research Center (J.J.S.), VA Connecticut Healthcare System, West Haven, CT; Department of Neurology (A.S.), Wake Forest School of Medicine, Winston Salem, NC; Department of Neurology (S.M.B.), University of Minnesota School of Medicine and Physicians Minneapolis, MN; Department of Neurology (N.A.B.), University of Pittsburgh School of Medicine, PA; Department of Pediatrics (B.H.C.), The Rebecca D. Considine Research Institute, Akron Children's Hospital, Akron, OH and The Northeast Ohio Medical University (B.H.C.), Rootstown, OH; Department of Neurology (R.R.D), University of Texas Southwestern Medical Center, Dallas, TX; International Essential Tremor Foundation (S.F.), Member of Henry Ford Health System Foundation Board, Member of Henry Ford Health System Neuroscience Institute Council of Advisors; Department of Neurosciences (J.J.H.), Atlantic Health, Summit, NJ; Department of Neurology (A.G.K.), University of Rochester, NY; Epilepsy Foundation of Minnesota (L.M.), Minneapolis, MN; Departments of Neurology and Epidemiology and Public Health (M.S.P.), University of Maryland School of Medicine, Baltimore, MD; Department of Neurology (P.D.T.), University of Pittsburgh Medical Center, PA; Neurology (R.V.), University of Rochester Medical Center, Rochester, NY; Indiana University School of Nursing (J.v.G.), Indianapolis, IN; American Academy of Neurology (A.B.), Minneapolis, MN; and Division of Neurology (A.M.S.), Mount Auburn Hospital, Cambridge, MA.

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http://dx.doi.org/10.1212/WNL.0000000000009525DOI Listing

Is there evidence of bradykinesia in essential tremor?

Eur J Neurol 2020 May 12. Epub 2020 May 12.

Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy.

Background And Purpose: Essential tremor (ET) is a movement disorder primarily characterized by upper limb postural and kinetic tremor. Although still under-investigated, bradykinesia may be part of the phenotypic spectrum of ET. The aim was to evaluate bradykinesia features in ET through clinical examination and kinematic analysis of repetitive finger movements. Read More

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http://dx.doi.org/10.1111/ene.14312DOI Listing

Features in essential tremor and the development of Parkinson's disease vs. parkinsonism.

Neurol Sci 2020 May 11. Epub 2020 May 11.

Department of Neurology, University of Miami Miller School of Medicine, 1120 NW 14th Street, Clinical Research Building, 13th floor, Miami, FL, 33136, USA.

Background: Patients with essential tremor (ET) are at higher risk to develop Parkinson's disease (PD). Recent studies suggest that propranolol (common treatment for ET) can augment pathologic expression of alpha-synuclein. We studied features associated with the development of Parkinson's disease with antecedant essential tremor (ET-PD) compared with ET-plus with parkinsonism (PK). Read More

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http://dx.doi.org/10.1007/s10072-020-04439-wDOI Listing

A Pilot Double-Blind Randomized Trial of Perampanel for Essential Tremor.

Mov Disord Clin Pract 2020 May 31;7(4):399-404. Epub 2020 Mar 31.

Department of Neurology Southern Illinois University School of Medicine Springfield Illinois USA.

Background: Perampanel is a noncompetitive antagonist of alpha-amino-3-hydroxy-5-methylisoxazole propionic acid glutamate receptors suggested to modulate tremor.

Objectives: To assess the efficacy and tolerability of perampanel for essential tremor.

Methods: This was a double-blind, placebo-controlled, randomized, cross-over trial involving 26 patients titrated to 8 mg/day or a lower maximally tolerated dose as monotherapy or adjunct to antitremor medication. Read More

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http://dx.doi.org/10.1002/mdc3.12927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197304PMC

Repeated group alternation as a programming strategy for essential tremor patients experiencing rapid habituation with deep brain stimulation treatment.

Int J Neurosci 2020 May 25:1-5. Epub 2020 May 25.

Department of Rehabilitation Medicine, University of Washington, Seattle, WA, USA.

The term habituation refers to the rapid loss of therapeutic effects that occurs following an initially beneficial adjustment of Deep Brain Stimulation (DBS) parameters. DBS habituation typically occurs over a period of days to weeks and has been observed in a subgroup of essential tremor (ET) patients undergoing stimulation of the ventral intermediate nucleus of the thalamus (VIM). The negative consequences of DBS habituation include protracted periods of ineffective therapy, the exacerbation of symptoms beyond presurgical levels (rebound), and the requirement for repeated office visits for stimulation adjustments. Read More

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http://dx.doi.org/10.1080/00207454.2020.1758083DOI Listing