4,173 results match your criteria Essential Tremor


Clinical correlates of abnormal subcortical volumes in Essential Tremor.

J Neural Transm (Vienna) 2019 Apr 20. Epub 2019 Apr 20.

Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Hosur Road, Bangalore, Karnataka, 560029, India.

Essential tremor (ET) is considered to be a neurodegenerative disorder and it is plausible that the observed motor and non-motor symptoms may be attributable to functional alterations secondary to abnormalities of subcortical nuclei. This study aims to compare the volumes of subcortical nuclei in patients with ET to ascertain neuroimaging correlates of motor and non-motor features of ET. Forty patients of ET and 40 age- and gender-matched healthy controls (HC) were enrolled in this study. Read More

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http://dx.doi.org/10.1007/s00702-019-02004-0DOI Listing

Computer vision of smartphone video has potential to detect functional tremor.

J Neurol Sci 2019 Apr 12;401:27-28. Epub 2019 Apr 12.

Department of Psychology, Queen's University Belfast, Belfast, Northern Ireland.

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http://dx.doi.org/10.1016/j.jns.2019.04.016DOI Listing

Spatiotemporal gait parameters and tremor distribution in essential tremor.

Gait Posture 2019 Apr 14;71:32-37. Epub 2019 Apr 14.

University of Florida, Gainesville, FL, United States.

Background: Essential Tremor is characterized by an action tremor of the upper extremities, which may or may not be accompanied by a head, voice, leg or trunk tremor. Problems with gait and balance have also been identified in persons with Essential Tremor. Therefore, understanding gait performance is an important area of focus for clinicians and researchers. Read More

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http://dx.doi.org/10.1016/j.gaitpost.2019.04.004DOI Listing
April 2019
1 Read

Association between restless legs syndrome and other movement disorders.

Neurology 2019 Apr 19. Epub 2019 Apr 19.

From the Section of Neurology (H.A.-N., F.J.J.-J.), Hospital Universitario del Sureste, Arganda del Rey, Madrid; and University Institute of Molecular Pathology Biomarkers (E.G.-M., J.A.G.A), UNEx, ARADyAL Instituto de Salud Carlos III, Cáceres, Spain.

Objective: This review focuses on the possible association between restless legs syndrome (RLS) and movement disorders, including Parkinson disease (PD), other parkinsonian syndromes, essential tremor, choreic and dystonic syndromes, Tourette syndrome, and heredodegenerative ataxias.

Methods: Review of PubMed from 1966 to September 2018 and identification of references of interest for the topic. A meta-analysis of eligible studies on the frequency of RLS in patients with PD and controls using Meta-DiSc1. Read More

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http://dx.doi.org/10.1212/WNL.0000000000007500DOI Listing

Natural history of neuromodulation devices and therapies: a patient-centered survival analysis.

J Neurosurg 2019 Apr 19:1-7. Epub 2019 Apr 19.

OBJECTIVEDespite rapid development and expansion of neuromodulation technologies, knowledge about device and/or therapy durability remains limited. The aim of this study was to evaluate the long-term rate of hardware and therapeutic failure of implanted devices for several neuromodulation therapies.METHODSThe authors performed a retrospective analysis of patients' device and therapy survival data (Kaplan-Meier survival analysis) for deep brain stimulation (DBS), vagus nerve stimulation (VNS), and spinal cord stimulation (SCS) at a single institution (years 1994-2015). Read More

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https://thejns.org/view/journals/j-neurosurg/aop/article-10.
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http://dx.doi.org/10.3171/2019.2.JNS182450DOI Listing
April 2019
1 Read

Clinical Characteristics of Essential Tremor in South India: A Hospital-Based Cohort Study.

J Neurosci Rural Pract 2019 Apr-Jun;10(2):245-249

Department of Neurology, Princess Esra Hospital, Deccan College of Medical Science, Hyderabad, Telangana, India.

Introduction: Essential tremor (ET) is the most common adult movement disorder. Classic ET is characterized by action tremor of hands (95% cases), and tremor involving other regions is less common. Recent studies have revealed a few patients exhibiting nontremor features that include cognitive disorders, tandem gait abnormality, mood fluctuations, olfactory abnormality, hearing impairment, and sleep disorders. Read More

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http://dx.doi.org/10.4103/jnrp.jnrp_348_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454942PMC

Connectivity derived thalamic segmentation: Separating myth from reality.

Neuroimage Clin 2019 Mar 20:101758. Epub 2019 Mar 20.

Unit of Functional Neurosurgery, Department of Clinical and Movement Neurosciences, UCL Institute of Neurology, Queen Square, London, UK.

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http://dx.doi.org/10.1016/j.nicl.2019.101758DOI Listing
March 2019
1 Read

Complexities of connectivity-based DBS targeting: Rebirth of the debate on thalamic and subthalamic treatment of tremor.

Neuroimage Clin 2019 Mar 20:101761. Epub 2019 Mar 20.

Center of Neurology and Neurosurgery Associates (NeuroCENNA), BP-A Beneficência Portuguesa de São Paulo, São Paulo, Brazil.

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http://dx.doi.org/10.1016/j.nicl.2019.101761DOI Listing

Mapping stimulation-induced beneficial and adverse effects in the subthalamic area of essential tremor patients.

Parkinsonism Relat Disord 2019 Apr 3. Epub 2019 Apr 3.

Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address:

Background: Stimulation of the subthalamic area (STA) is an effective treatment in essential tremor patients, but limited by stimulation induced adverse effects. The aim of this study was to determine the spatial distribution of stimulus related tremor suppression, ataxia induction and paresthesia of the upper limb in the subthalamic area (STA) of essential tremor patients.

Methods: We recruited eight patients with essential tremor in a stable postoperative condition (>3 months after surgery). Read More

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http://dx.doi.org/10.1016/j.parkreldis.2019.03.028DOI Listing

Neuroimaging and neuropathological findings in essential tremor.

Acta Neurol Scand 2019 Apr 11. Epub 2019 Apr 11.

Third Department of Neurology, Aristotle University of Thessaloniki, Greece.

Essential Tremor is a chronic neurological syndrome of heterogenous clinical phenotypes and multiple aetiologies. Numerous studies have been done in order to investigate the pathological, neuroimaging, physiological and clinical features of essential tremor; however a clear pathyphysiological mechanism has not been identified. One of the brain structures that has been extensively investigated at the macroscopic and the microscopic level in the cerebellum. Read More

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http://dx.doi.org/10.1111/ane.13101DOI Listing
April 2019
2 Reads

Segmented versus Nonsegmented Deep-Brain Stimulation for Essential Tremor Differ in Ataxic Side Effects.

Authors:
Daniel A Roque

Tremor Other Hyperkinet Mov (N Y) 2019 29;9:621. Epub 2019 Mar 29.

University of North Carolina at Chapel Hill, North Carolina, US.

Background: Directional, deep-brain stimulation may prove beneficial for targets (1) thinner along the lead trajectory, and (2) whose borders are not easily visible by neuroimaging. When targeting the ventral intermediate (VIM) nucleus of the thalamus for essential tremor, even baseline ataxia may be exacerbated by medial spread of current and antidromic stimulation of vestibular-cerebellar-thalamic afferents.

Case Report: The present patient with essential tremor developed refractory head tremor leading to implantation of bilateral St. Read More

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http://dx.doi.org/10.7916/d8-8vww-td18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451654PMC
March 2019
1 Read

Erythropoietin ameliorates harmaline-induced essential tremor and cognition disturbances.

Neurosci Lett 2019 Apr 8;704:153-158. Epub 2019 Apr 8.

Neuroscience Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, Iran. Electronic address:

There are conflicting reports concerning the association of motor disabilities with increased risk of mental disorders. This investigation will provide a good understanding about defining the possible association between tremor and risk of anxiety and cognitive alterations. Beside, a secondary objective of the current study was to determine the effect of erythropoietin (EPO) on harmaline-induced motor and cognitive impairments. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.04.017DOI Listing

Post-diagnostic lived experiences of individuals with essential tremor.

Disabil Rehabil 2019 Apr 11:1-9. Epub 2019 Apr 11.

a Division of Health Research , Lancaster University , Lancaster , UK.

Purpose: This research study aimed to explore the lived experience of individuals with essential tremor.

Method: This study was qualitative in nature and informed by interpretative phenomenological analysis methodology. Semi-structured interviews were conducted with a relatively homogenous sample of nine individuals with a diagnosis of essential tremor. Read More

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http://dx.doi.org/10.1080/09638288.2019.1574915DOI Listing
April 2019
3 Reads

Network-level connectivity is a critical feature distinguishing dystonic tremor and essential tremor.

Brain 2019 Apr 8. Epub 2019 Apr 8.

Department of Neurology, College of Medicine, University of Florida, Gainesville, FL, USA.

Dystonia is a movement disorder characterized by involuntary muscle co-contractions that give rise to disabling movements and postures. A recent expert consensus labelled the incidence of tremor as a core feature of dystonia that can affect body regions both symptomatic and asymptomatic to dystonic features. We are only beginning to understand the neural network-level signatures that relate to clinical features of dystonic tremor. Read More

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http://dx.doi.org/10.1093/brain/awz085DOI Listing
April 2019
4 Reads

Tremor in normal adults: A population-based study of 1158 adults in the Faroe Islands.

J Neurol Sci 2019 May 21;400:169-174. Epub 2019 Mar 21.

Department of Occupational Medicine and Public Health, The Faroese Hospital System, Tórshavn, Faroe Islands; Centre for Health Science, Faculty of Health Sciences, University of the Faroe Islands, Tórshavn, Faroe Islands.

There are virtually no population-based data on tremor in normal individuals. Using a population-based sample of 1158 normal adults ages 40-98 years in the Faroe Islands, we characterized the extent of normal action tremor across age and gender strata. Participants drew two Archimedes spirals with each hand, and tremor was systematically quantified by a senior movement disorder neurologist using a reliable and valid ordinal rating scale (ratings = 0-3). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0022510X193014
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http://dx.doi.org/10.1016/j.jns.2019.03.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475466PMC
May 2019
12 Reads

Clinical approach to tremor in children.

Parkinsonism Relat Disord 2019 Mar 23. Epub 2019 Mar 23.

Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE, 68198, United States. Electronic address:

Pediatric Movement Disorders encompass a very large and complex group of diseases, among which Tremor is one of the least studied. Evaluation of tremors in kids carries significant challenges, in particular the fact that many tremor etiologies have other associated movement disorders that make tremor identification more difficult. Also, it is sometimes difficult to differentiate tremors from other shaking disorders. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2019.03.015DOI Listing
March 2019
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Analysis of the prevalence and onset of dysphonia and dysphagia symptoms in movement disorders at an academic medical center.

J Clin Neurosci 2019 Apr 1. Epub 2019 Apr 1.

Department of Neurology, Wake Forest School of Medicine, Winston-Salem, NC, USA.

Voice and swallowing impairments are common in movement disorders, but their effect on patients' quality of life is not well known. This study was conducted to determine the onset and prevalence of patient-reported dysphonia and dysphagia symptoms in Parkinson's disease (PD), dystonia, Atypical Parkinsonian Syndromes (APS), and Essential Tremor (ET). Patients referred to a movement disorders clinic in a tertiary care academic medical center completed validated voice and swallowing specific Quality of Life (QOL) questionnaires: Voice Handicap Index-10 (VHI-10) and Eating Assessment Tool-10 (EAT-10). Read More

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http://dx.doi.org/10.1016/j.jocn.2019.03.043DOI Listing
April 2019
3 Reads

Demoralization in essential tremor: prevalence, clinical correlates, and dissociation from tremor severity.

CNS Spectr 2019 Apr 3:1-8. Epub 2019 Apr 3.

Center for Neuroepidemiology and Clinical Neurological Research & Division of Movement Disorders, Department of Neurology, Yale School of Medicine & Department of Chronic Disease Epidemiology, Yale School of Public Health,Yale University,New Haven, Connecticut,USA.

Objective: Essential tremor (ET) is associated with psychological difficulties, including anxiety and depression. Demoralization (feelings of helplessness, hopelessness, inability to cope), another manifestation of psychological distress, has yet to be investigated in ET. Our objectives are to (1) estimate the prevalence of demoralization in ET, (2) assess its clinical correlates, and (3) determine whether demoralization correlates with tremor severity. Read More

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http://dx.doi.org/10.1017/S1092852918001633DOI Listing
April 2019
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Minimal clinically important difference for the quality of life in essential tremor questionnaire.

Mov Disord 2019 Apr 2. Epub 2019 Apr 2.

Department of Neurology, Medical School, University of Pécs, Pécs, Hungary.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/mds.27660
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http://dx.doi.org/10.1002/mds.27660DOI Listing
April 2019
3 Reads

Elevated Plasma microRNA-105-5p Level in Patients With Idiopathic Parkinson's Disease: A Potential Disease Biomarker.

Front Neurosci 2019 18;13:218. Epub 2019 Mar 18.

Center for Clinical Research on Neurological Diseases, The First Affiliated Hospital, Dalian Medical University, Dalian, China.

Parkinson's disease (PD) is the second most common neurodegenerative disease, which still lacks a biomarker to aid in diagnosis and to differentiate diagnosis at the early stage of the disease. microRNAs (miRNAs) are small and evolutionary conserved non-coding RNAs that are involved in post-transcriptional gene regulation. Several miRNAs have been proposed as potential biomarkers in several diseases. Read More

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http://dx.doi.org/10.3389/fnins.2019.00218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431626PMC
March 2019
1 Read

A Rare Case of Pseudo-atrial Flutter Waves in a Patient with Essential Tremor.

Cureus 2019 Jan 21;11(1):e3934. Epub 2019 Jan 21.

Cardiology, 424 General Military Hospital, Thessaloniki, GRC.

High-frequency muscle tremor can mimic atrial flutter. Unnecessary therapies and aggressive interventions may have devastating consequences in these cases. We present a case of a patient with global pseudo-atrial flutter waves in the setting of essential tremor strictly confined to the arms. Read More

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http://dx.doi.org/10.7759/cureus.3934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430307PMC
January 2019
1 Read

Cerebellar repetitive transcranial magnetic stimulation for patients with essential tremor.

Parkinsonism Relat Disord 2019 Mar 24. Epub 2019 Mar 24.

Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea.

Introduction: The possibility of repetitive transcranial magnetic stimulation (rTMS) as an alternative therapy for essential tremor (ET) patients has emerged. However, its effect on medicated ET patients is lacking. The aim of this pilot study was to investigate the effect of cerebellar low-frequency rTMS as an "add-on" treatment. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2019.03.019DOI Listing
March 2019
5 Reads

Longitudinal analysis of structural changes following unilateral focused ultrasound thalamotomy.

Neuroimage Clin 2019 Mar 12;22:101754. Epub 2019 Mar 12.

Center for Neuromodulation, The Ohio State University, 480 Medical Center Dr., Columbus, OH 43210, USA. Electronic address:

Objective: Focused ultrasound thalamotomy is an emerging treatment for essential tremor, and it is ideal for studying reorganization in the human brain after acute injury because it creates a controlled thalamic ablation without breaching the cortex. However, there is not yet a metric capable of detecting microstructural changes in the presence of acute phase edema with good sensitivity in the chronic phase, when the lesion boundaries become inconspicuous.

Methods: We prospectively studied microstructural changes at the lesion site using generalized q-sampling imaging with restricted diffusion imaging. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439211PMC
March 2019
1 Read

Bilateral clicking tinnitus due to myoclonus of middle ear muscles.

N Z Med J 2019 Mar 29;132(1492):67-69. Epub 2019 Mar 29.

Otolaryngologist Department of Otolaryngology, Head and Neck Surgery, Christchurch Hospital, Christchurch.

Isolated middle ear myoclonus can be a cause of objective tinnitus. We present an acoustically documented case of irregular bilateral middle ear myoclonus with loud clicking, and roaring tinnitus associated with essential palatal tremor. A palatal botulinum toxin injection did not eliminate the tinnitus. Read More

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Robotic radical lymphadenectomy without touching the pancreas during gastrectomy for gastric cancer.

Medicine (Baltimore) 2019 Mar;98(13):e15091

Second Department of Surgery, Wakayama Medical University, Wakayama, Japan.

Laparoscopic lymph node dissection around the peripancreatic area for gastric cancer (GC) remains challenging because of drawbacks in laparoscopic surgery including the limited range of movement, amplification of hand tremors, and inconvenient surgical positioning. In some cases of laparoscopic gastrectomy (LG), therefore, postoperative pancreatic fistula (POPF) occurs. Robotic surgery, on the other hand, plays an essential role in ergonomics and offers advantages, such as motion scaling, less fatigue, tremor filtering, 7 degrees of motion in the robotic instruments assisted by the wrist-like instruments tips, and three-dimensional vision. Read More

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http://dx.doi.org/10.1097/MD.0000000000015091DOI Listing
March 2019
1 Read

Adapted Feeding Utensils for People With Parkinson's-Related or Essential Tremor.

Am J Occup Ther 2019 Mar/Apr;73(2):7302205120p1-7302205120p9

Joyce Starr, MS, OTR, was Graduate Student, Occupational Therapy Program, State University of New York (SUNY) Downstate, Brooklyn, at the time of the study.

Objective: Our objective was to evaluate the effectiveness of four adapted feeding utensils with participants with essential tremor (ET) or tremor related to Parkinson's disease (PD).

Method: Participants performed a simulated feeding task under five conditions: (1) standard spoon (control condition), (2) weighted spoon with standard handle, (3) weighted spoon with built-up handle, (4) swivel spoon, and (5) Liftware Steady™ spoon, a product using active tremor cancellation technology. Participants rated each adapted utensil in comparison with the standard spoon regarding performance, ease of use, speed, neatness, and aesthetics. Read More

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http://dx.doi.org/10.5014/ajot.2019.030759DOI Listing

Essential Tremor is not Only a Movement Disorder; Its Relationship with Sleep and Anxiety.

Noro Psikiyatr Ars 2019 Mar 17;56(1):18-22. Epub 2018 Sep 17.

Department of Neurology, Sakarya University Faculty of Medicine, Sakarya, Turkey.

Introduction: Essential tremor (ET) is the most common movement disorder, and some studies suggest that there are non-motor symptoms as well as motor symptoms. This study aims to investigate the relationship between ET and anxiety and sleep disorder.

Methods: The study was conducted with 38 healthy individuals in the control group and 40 patients who admitted to the neurology clinic of our hospital and had definite ET according to the (PSQI) and (HAM-A) were applied to both groups. Read More

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http://dx.doi.org/10.5152/npa.2017.22858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427083PMC
March 2019
1 Read

Feasibility of ultrashort echo time images using full-wave acoustic and thermal modeling for transcranial MRI-guided focused ultrasound (tcMRgFUS) planning.

Phys Med Biol 2019 Mar 25. Epub 2019 Mar 25.

Center for Metabolic Imaging and Therapeutics (CMIT), University of Maryland School of Medicine, Baltimore, Maryland, UNITED STATES.

Transcranial MRI-guided focused ultrasound (tcMRgFUS) is increasingly used to non-invasively treat a wide variety of neurological disorders including essential tremors, Parkinson disease and neuropathic pain. Although this treatment is an MRI-guided procedure, the current pre-treatment screening and planning involve a CT of the head to obtain three-dimensional skull images. These images are necessary for estimating the proportion of absorbed energy and the acoustic phase shift associated with the skull and determining the transmit energy of ultrasonic wave to create thermal lesions at a desired focal spot. Read More

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http://dx.doi.org/10.1088/1361-6560/ab12f7DOI Listing
March 2019
1 Read

Deep Brain Stimulation for Treatment of Tremor.

Neurosurg Clin N Am 2019 Apr;30(2):147-159

Vanderbilt University Medical Center, Room 4333, VAV, 1500 21st Avenue, Nashville, TN 37212, USA. Electronic address:

Deep brain stimulation is now the most common surgical treatment of tremor. Tremor can be classified as action or resting tremor and is one of the most common movement disorders. Initial treatment of tremor should focus on medical treatment but, if patients fail medical therapy, deep brain stimulation should be considered with likely success. Read More

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http://dx.doi.org/10.1016/j.nec.2019.01.002DOI Listing

[Tremor: A Clinical Guide For The Non-Neurologist].

Acta Med Port 2019 Feb 28;32(2):149-157. Epub 2019 Feb 28.

Unidade de Doenças do Movimento e Cirurgia Funcional. Serviço de Neurologia. Centro Hospitalar Universitário de São João. Porto. Departamento de Neurociências Clínicas e Saúde Mental. Faculdade de Medicina. Universidade do Porto. Porto. Portugal.

Tremor is the commonest involuntary movement. The differential diagnosis is wide, and can be challenging even for experienced neurologists. Nonetheless, many tremors have a benign etiology and clinical course and, in many cases, non-neurologists are able to clinically manage these situations. Read More

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http://dx.doi.org/10.20344/amp.11352DOI Listing
February 2019
2 Reads

Neurotoxicity associated with cancer immunotherapy: immune checkpoint inhibitors and chimeric antigen receptor T-cell therapy.

Curr Opin Neurol 2019 Mar 19. Epub 2019 Mar 19.

Department of Oncology.

Purpose Of Review: Immune checkpoint inhibitors (ICPI) and chimeric antigen receptor T cells (CAR-T) represent novel therapies recently approved to treat a number of human cancers. As both approaches modulate the immune system, they can generate a number of immune-related adverse events (irAEs), including a large spectrum of novel neurological toxicities. These are of special interest given their potential severity and risk of compromising further oncologic treatment. Read More

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http://dx.doi.org/10.1097/WCO.0000000000000686DOI Listing
March 2019
2 Reads

Patient Companionship in a Movement Disorders Clinic: Outside Assistance Inside the Office.

Front Neurol 2019 5;10:182. Epub 2019 Mar 5.

Division of Movement Disorders, Department of Neurology, Yale School of Medicine, Yale University, New Haven, CT, United States.

We (1) report whether a companion (i.e., spouse, relative, aide) accompanied our consecutive outpatients with a range of movement disorders, (2) identified the set of patient characteristics that was associated with the need for a visit companion, and (3) characterized the role(s) of these companions during the visit. Read More

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http://dx.doi.org/10.3389/fneur.2019.00182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411683PMC
March 2019
1 Read

Prevalence of Essential Tremor in the Faroe Islands: A Population-Based Study.

Neuroepidemiology 2019 Mar 19;52(3-4):227-236. Epub 2019 Mar 19.

Department of Occupational Medicine and Public Health, The Faroese Hospital Systems, Tórshavn, Faeroe Islands.

Background: No studies of the prevalence of one of the most common movement disorders, essential tremor (ET), have been undertaken in the Faroe Islands. Given the potential for founder effects in the Islands, and the highly genetic nature of ET, the Faroe Islands provide a particularly interesting setting in which to study the prevalence of ET.

Objective: To estimate the prevalence of ET and study its characteristics. Read More

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http://dx.doi.org/10.1159/000499070DOI Listing

Deep brain stimulation for obsessive-compulsive disorder.

Bull Menninger Clin 2019 ;83(1):84-96

Department of Neurosurgery, Baylor College of Medicine, Houston, Texas.

Neurosurgical interventions have been used for decades to treat severe, refractory obsessive-compulsive disorder (OCD). Deep brain stimulation (DBS) is a neurosurgical procedure that is used routinely to treat movement disorders such as Parkinson's disease and essential tremor. Over the past two decades, DBS has been applied to OCD, building on earlier experience with lesional procedures. Read More

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http://dx.doi.org/10.1521/bumc.2019.83.1.84DOI Listing
January 2019
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Abnormal hippocampal subfields are associated with cognitive impairment in Essential Tremor.

J Neural Transm (Vienna) 2019 Mar 19. Epub 2019 Mar 19.

Department of Neurology, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore, Karnataka, 560029, India.

Multi-domain cognitive impairment (CI) has been frequently described in patients with essential tremor (ET). However, the exact neuroanatomical basis for this impairment is uncertain. This study aims to ascertain the role of the hippocampal formation in cognitive impairment in ET. Read More

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http://link.springer.com/10.1007/s00702-019-01992-3
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http://dx.doi.org/10.1007/s00702-019-01992-3DOI Listing
March 2019
3 Reads

Focused Ultrasound Thalamotomy for Essential Tremor in the Setting of a Ventricular Shunt: Technical Report.

Oper Neurosurg (Hagerstown) 2019 Mar 19. Epub 2019 Mar 19.

Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Background: A recent randomized controlled trial of magnetic resonance imaging (MRI)-guided focused ultrasound (FUS) for essential tremor (ET) demonstrated safety and efficacy. Patients with ventricular shunts may be good candidates for FUS to minimize hardware-associated infections.

Objective: To demonstrate feasibility of FUS in this subset of patients. Read More

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https://academic.oup.com/ons/advance-article/doi/10.1093/ons
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http://dx.doi.org/10.1093/ons/opz013DOI Listing
March 2019
1 Read

Neuropathology of Dystonia.

Authors:
Nutan Sharma

Tremor Other Hyperkinet Mov (N Y) 2019 25;9:569. Epub 2019 Feb 25.

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, US.

Background: Dystonia is characterized by sustained or intermittent muscle contractions resulting in abnormal, often repetitive, movements, postures, or both. Neuropathologic research has been essential in understanding the etiology and disease progression of other movement disorders, including Parkinson's disease and cerebellar ataxias. In the field of dystonia, however, research is stymied by the paucity of post-mortem tissue available and the phenotypic heterogeneity found in those with dystonia. Read More

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http://dx.doi.org/10.7916/d8-j6sx-b156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420908PMC
April 2019
1 Read

Mind the gaps: What we don't know about cognitive impairment in essential tremor.

Parkinsonism Relat Disord 2019 Mar 1. Epub 2019 Mar 1.

Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA.

Introduction: Although the hallmark feature of essential tremor (ET) is tremor, there is growing appreciation that cognitive impairment also occurs, including increased prevalence of mild cognitive impairment (MCI) and increased prevalence and incidence of dementia. With emerging knowledge of ET-cognitive impairment, come fundamental questions regarding its course, bases, predictors and clinical outcomes. Studies in the general population and in Parkinson's disease (PD), a related movement disorder, offer a starting point from which to begin filling these clinically important knowledge gaps. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2019.02.038DOI Listing
March 2019
2 Reads

Modulation of saccades in humans by electrical stimulation of the posterior subthalamic area.

J Neurosurg 2019 Mar 15:1-9. Epub 2019 Mar 15.

1Neurosurgical Service of Western Australia and.

OBJECTIVEPosterior subthalamic area (PSA) deep brain stimulation (DBS) targeting the zona incerta (ZI) is an emerging treatment for tremor syndromes, including Parkinson's disease (PD) and essential tremor (ET). Evidence from animal studies has indicated that the ZI may play a role in saccadic eye movements via pathways between the ZI and superior colliculus (incerto-collicular pathways). PSA DBS permitted testing this hypothesis in humans. Read More

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http://dx.doi.org/10.3171/2018.12.JNS18502DOI Listing
March 2019
2 Reads

Eye movement abnormalities in essential tremor versus tremor dominant Parkinson's disease.

Clin Neurophysiol 2019 May 23;130(5):683-691. Epub 2019 Feb 23.

Department of Neurology and Clinical Neurophysiology, Amsterdam UMC, University of Amsterdam, Amsterdam Neuroscience, Meibergdreef 9, 1105 AZ Amsterdam-Zuidoost, the Netherlands. Electronic address:

Objective: To show that eye movement abnormalities differ between essential tremor (ET) and tremor dominant Parkinson's disease (PD-T), and that these abnormalities reflect cerebellar dysfunction in ET and basal ganglia pathology in PD-T.

Methods: In this exploratory study, in 23 patients with ET, 21 age-matched patients with PD-T, and 19 age-matched healthy controls (HCs), we investigated visually guided saccades, antisaccades, and smooth pursuit eye movements (SPEM).

Results: While the ET group had a normal gain (saccade amplitude/target amplitude) and latency of saccades, the PD-T group had hypometric visually guided saccades, and a prolonged latency of visually guided saccades and antisaccades. Read More

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http://dx.doi.org/10.1016/j.clinph.2019.01.026DOI Listing
May 2019
5 Reads

Anti-Neurofascin-155 IgG4 antibodies prevent paranodal complex formation in vivo.

J Clin Invest 2019 Mar 14;130. Epub 2019 Mar 14.

Neurofascin-155 (Nfasc155) is an essential glial cell adhesion molecule expressed in paranodal septate-like junctions of peripheral and central myelinated axons. The genetic deletion of Nfasc155 results in the loss of septate-like junctions and in conduction slowing. In humans, IgG4 antibodies against Nfasc155 are implicated in the pathogenesis of chronic inflammatory demyelinating polyneuropathy (CIDP). Read More

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http://dx.doi.org/10.1172/JCI124694DOI Listing
March 2019
2 Reads

[Essential tremor].

Authors:
Bertrand Degos

Rev Prat 2018 Jun;68(6):654-656

Service de neurologie, hôpital Avicenne, Hôpitaux universitaires de Paris - Seine- Saint-Denis, AP-HP, Bobigny, France. Center for Interdisciplinary Research in Biology, Collège de France, Inserm U1050, CNRS UMR7241, Labex Memolife, Paris Sciences et Lettres, Paris, France.

Essential tremor. Essential tremor is very common in the general population. It is a postural tremor occurring in adulthood, evolving progressively and whose severity can be very variable from one individual to another. Read More

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Pallidal thermolesion unleashes gamma oscillations in the motor cortex in Parkinson's disease.

Mov Disord 2019 Mar 13. Epub 2019 Mar 13.

Department of Neurological Surgery, University of California San Francisco, San Francisco, California, USA.

Background: In Parkinson's disease, the emergence of motor dysfunction is thought to be related to an imbalance between "antikinetic" and "prokinetic" patterns of oscillatory activity in the motor network. Invasive recordings from the basal ganglia and cortex in surgical patients have suggested that levodopa and therapeutic deep brain stimulation can suppress antikinetic beta band (13-30 Hz) rhythms while promoting prokinetic gamma band (60-90 Hz) rhythms. Surgical ablation of the globus pallidus internus is one of the oldest effective therapies for Parkinson's disease and produces remarkably immediate relief of rigidity and bradykinesia, but its effects on oscillatory activity in the motor network have not been studied. Read More

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http://dx.doi.org/10.1002/mds.27658DOI Listing
March 2019
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Dementia in Essential Tremor: A Visual Record.

Tremor Other Hyperkinet Mov (N Y) 2019 6;9:635. Epub 2019 Mar 6.

Department of Neurology, Yale School of Medicine, Yale University, New Haven, CT, US.

Background: Research studies have shown an association between essential tremor (ET) and dementia, although dementia in ET is not often regarded as a clinically important issue.

Phenomenology Shown: We present three tangible visual records of patients with ET who have developed concurrent, comorbid dementia.

Educational Value: ET is a risk factor for dementia. Read More

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http://dx.doi.org/10.7916/d8-eh2t-5m82DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411478PMC
April 2019
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An Unusual Case of Essential Tremor Deep Brain Stimulation: Where is the Lead?

Tremor Other Hyperkinet Mov (N Y) 2019 7;9:617. Epub 2019 Mar 7.

Fixel Center for Neurological Diseases, Program in Movement Disorders and Neurorestoration, Department of Neurology, University of Florida, Gainesville, FL, US.

Clinical Vignette: A 73-year-old female with essential tremor (ET) underwent bilateral thalamic ventralis intermedius (Vim) deep brain stimulation (DBS) surgery. The leads provided tremor benefit, but the location was suboptimal and contributed to stimulation-induced hemichorea.

Clinical Dilemma: Can patients with ET derive benefit when stimulating outside the Vim? What do we know about stimulation-induced hemichorea in the setting of ET?

Clinical Solution: Lead localization combined with advanced programming strategies can be employed to troubleshoot DBS in settings when benefits are observed along with adverse effects. Read More

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http://dx.doi.org/10.7916/d8-xj6w-cm53DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411417PMC
April 2019
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Microstructural changes of the dentato-rubro-thalamic tract after transcranial MR guided focused ultrasound ablation of the posteroventral VIM in essential tremor.

Hum Brain Mapp 2019 Mar 13. Epub 2019 Mar 13.

CINAC (Centro Integral de Neurociencias), University Hospital HM Puerta del Sur, CEU-San Pablo University, Madrid, Spain.

Essential tremor is the most common movement disorder in adults. In patients who are not responsive to medical treatment, functional neurosurgery and, more recently, transcranial MR-guided focused ultrasound thalamotomy are considered effective therapeutic approaches. However, the structural brain changes following a thalamotomy that mediates the clinical improvement are still unclear. Read More

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http://dx.doi.org/10.1002/hbm.24569DOI Listing

Cardiac 123I-MIBG Scintigraphy in Neurodegenerative Parkinson Syndromes: Performance and Pitfalls in Clinical Practice.

Front Neurol 2019 26;10:152. Epub 2019 Feb 26.

Movement Disorders and Neuromodulation Section, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Cardiac [I]metaiodobenzylguanidine scintigraphy (123I-MIBG), reflecting postganglionic cardiac autonomic denervation, is proposed for early detection of Parkinson's disease (PD; reduced tracer uptake) and separation from Multiple System Atrophy (MSA; preserved tracer uptake). However, several recent studies report on frequent unexpected 123I-MIBG results in PD and MSA. We sought to determine, whether 123I-MIBG is feasible to discriminate PD from MSA in unselected geriatric patients in clinical practice. Read More

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http://dx.doi.org/10.3389/fneur.2019.00152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399127PMC
February 2019
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Intraoperative High Impedance Levels During Placement of Deep Brain Stimulating Electrode.

Oper Neurosurg (Hagerstown) 2019 Mar 12. Epub 2019 Mar 12.

Department of Neurological Surgery Mayo Clinic Arizona Phoenix, Arizona.

Background And Importance: Deep brain stimulation (DBS) is a well-established treatment for medically refractory Parkinson's disease (PD), essential tremor (ET), and dystonia. The field of DBS is expanding and techniques are under investigation for the treatment of several neurological disorders. A critical component of the success of these procedures depends significantly on the reliability and durability of devices implanted. Read More

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https://academic.oup.com/ons/advance-article/doi/10.1093/ons
Publisher Site
http://dx.doi.org/10.1093/ons/opz035DOI Listing
March 2019
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Movement disorders in early MS and related diseases: A prospective observational study.

Neurol Clin Pract 2019 Feb;9(1):24-31

Multiple Sclerosis and Neuroimmunology Program (HA), University Hospitals of Cleveland; Case Western Reserve University School of Medicine (HA, KK), Cleveland; and Center for Neurological Restoration (XXY, HHF) and The Mellen Center for Multiple Sclerosis Treatment and Research (JAC), Cleveland Clinic, OH.

Background: Little is known about the true prevalence and clinical characteristics of movement disorders in early multiple sclerosis (MS) and related demyelinating diseases. We conducted a prospective study to fill this knowledge gap.

Methods: A consecutive patient sample was recruited from the MS clinic within a 1-year-period. Read More

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http://dx.doi.org/10.1212/CPJ.0000000000000560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382384PMC
February 2019
2 Reads

Enfeeblement in Essential Tremor: Development and Validation of a New Psychometric Measure.

J Geriatr Psychiatry Neurol 2019 May 11;32(3):145-151. Epub 2019 Mar 11.

1 Division of Movement Disorders, Department of Neurology, Yale School of Medicine, Yale University, New Haven, CT, USA.

Introduction: Despite a growing body of knowledge regarding essential tremor (ET), past studies have fallen short in capturing the full impact of ET on patients and caregivers. We propose enfeeblement (i.e. Read More

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http://dx.doi.org/10.1177/0891988719834345DOI Listing
May 2019
3 Reads