19,769 results match your criteria Esophagus Carcinoma


Recurrent activations of transient receptor potential vanilloid-1 and vanilloid-4 promote cellular proliferation and migration in esophageal squamous cell carcinoma cells.

FEBS Open Bio 2019 Feb 18;9(2):206-225. Epub 2019 Jan 18.

Key Laboratory of Regenerative Biology Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences Guangzhou China.

Some members of the transient receptor potential vanilloid (TRPV) subfamily of cation channels are thermosensitive. Earlier studies have revealed the distribution and functions of these thermo-TRPVs (TRPV1-4) in various organs, but their expression and function in the human esophagus are not fully understood. Here, we probed for the expression of the thermo-TRPVs in one nontumor human esophageal squamous cell line and two esophageal squamous cell carcinoma (ESCC) cell lines. Read More

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http://dx.doi.org/10.1002/2211-5463.12570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356177PMC
February 2019

The impact of reducing alcohol consumption in Australia: an estimate of the proportion of potentially avoidable cancers 2013-2037.

Int J Cancer 2019 Feb 12. Epub 2019 Feb 12.

Population Health Department, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, Queensland 4006, Australia.

The International Agency for Research on Cancer first concluded that alcohol causes cancer in humans in 1988. The World Cancer Research Fund has declared that alcohol causes cancer of the oral cavity, pharynx, larynx, oesophagus (squamous cell carcinoma), female breast, colon, rectum, stomach and liver. It recommended that alcohol be avoided altogether to prevent cancer. Read More

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http://dx.doi.org/10.1002/ijc.32204DOI Listing
February 2019

Tisotumab vedotin in patients with advanced or metastatic solid tumours (InnovaTV 201): a first-in-human, multicentre, phase 1-2 trial.

Lancet Oncol 2019 Feb 7. Epub 2019 Feb 7.

Department of Oncology, Phase 1 Unit, Rigshospitalet, Copenhagen, Denmark.

Background: Tisotumab vedotin is a first-in-human antibody-drug conjugate directed against tissue factor, which is expressed across multiple solid tumour types and is associated with poor clinical outcomes. We aimed to establish the safety, tolerability, pharmacokinetic profile, and antitumour activity of tisotumab vedotin in a mixed population of patients with locally advanced or metastatic (or both) solid tumours known to express tissue factor.

Methods: InnovaTV 201 is a phase 1-2, open-label, dose-escalation and dose-expansion study done at 21 centres in the USA and Europe. Read More

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http://dx.doi.org/10.1016/S1470-2045(18)30859-3DOI Listing
February 2019

Primary small cell carcinoma of the esophagus: Comparison between a Chinese cohort and Surveillance, Epidemiology, and End Results (SEER) data.

Cancer Med 2019 Feb 10. Epub 2019 Feb 10.

Key Laboratory of Translational Radiation Oncology, Department of Radiation Oncology, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School Of Medicine, Central South University, Hunan Province, Changsha, China.

Background: The optimal standard treatment for primary small cell carcinoma of the esophagus (SCCE) remains undetermined. In this study, we conducted two areas of research on SCCE. First, we analyzed differences in SCCE characteristics between Chinese and U. Read More

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http://dx.doi.org/10.1002/cam4.2001DOI Listing
February 2019

Safe Introduction of Minimally Invasive Esophagectomy at a Medium Volume Center.

Scand J Surg 2019 Feb 11:1457496919826722. Epub 2019 Feb 11.

Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.

Background And Aims:: Minimally invasive esophagectomy is a favored alternative in high-volume centers. We evaluated the introduction of, and transition to, minimally invasive esophagectomy at a medium volume tertiary referral center (10-20 esophagectomies annually) with focus on surgical results.

Material And Methods:: Patients who underwent minimally invasive esophagectomy or open transthoracic surgery for carcinoma of the esophagus or gastroesophageal junction (Siewert I and II) during 2007-2016 were retrospectively studied. Read More

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http://dx.doi.org/10.1177/1457496919826722DOI Listing
February 2019
1 Read

Molecular characterization of "sessile serrated" adenoma to carcinoma transition in six early colorectal cancers.

Pathol Res Pract 2019 Feb 3. Epub 2019 Feb 3.

Department of Medicine (DIMED), Surgical Pathology Unit, University of Padua, Padua, 35121, Italy.

Colorectal cancer (CRC) is a heterogeneous group of diseases both from the morphological and molecular point of view. The sessile serrated adenoma/polyp (SSA/P) has been proposed as the precursor lesion of CRCs characterized by CpG island methylator phenotype (CIMP), DNA mismatch repair (MMR) system deficiency, and BRAF gene mutations. However, no study so far investigated the molecular landscape of "sessile serrated" adenoma to carcinoma transition in early CRCs. Read More

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http://dx.doi.org/10.1016/j.prp.2019.02.001DOI Listing
February 2019
1 Read

A feasibility study of mediastinoscopic radical esophagectomy for thoracic esophageal cancer from the viewpoint of the dissected mediastinal lymph nodes validated with thoracoscopic procedure: a prospective clinical trial.

Esophagus 2019 Feb 8. Epub 2019 Feb 8.

Department of Gastrointestinal Surgery, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.

Purpose: A prospective trial evaluated the feasibility and safety of "mediastinoscopic esophagectomy with lymph node dissection" (MELD).

Methods: Eligible patients had thoracic esophageal squamous cell carcinoma, excluding T4, a bulky primary lesion or distant metastasis. Ten patients were enrolled and treated between September 2015 and March 2018. Read More

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http://dx.doi.org/10.1007/s10388-018-00656-7DOI Listing
February 2019
1 Read

Hypofractionated Radiotherapy in Oesophageal Cancer for Patients Unfit for Systemic Therapy: A Retrospective Single-Centre Analysis.

Clin Oncol (R Coll Radiol) 2019 Feb 5. Epub 2019 Feb 5.

Radiotherapy Research Group, Leeds Cancer Centre, The Leeds Teaching Hospitals NHS Trust, Leeds, UK. Electronic address:

Aims: Chemoradiotherapy (CRT) is established as a superior treatment option to definitive radiotherapy in the non-surgical management of oesophageal cancer. For patients precluded from CRT through choice or comorbidity there is little evidence to guide delivery of single-modality radiotherapy. In this study we outline outcomes for patients unfit for CRT who received a hypofractionated radiotherapy (HRT) regimen. Read More

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http://dx.doi.org/10.1016/j.clon.2019.01.010DOI Listing
February 2019

KEYNOTE-590: Phase III study of first-line chemotherapy with or without pembrolizumab for advanced esophageal cancer.

Future Oncol 2019 Feb 8. Epub 2019 Feb 8.

National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, 277-8577, Japan.

Background: Treatment options for patients with advanced esophageal or esophagogastric junction (EGJ) cancer are limited. Current guidelines for first-line treatment of advanced esophageal or EGJ cancer recommend chemotherapy containing a platinum and a fluoropyrimidine agent. Pembrolizumab demonstrated antitumor activity in previously treated patients with advanced esophageal cancer and in patients with gastroesophageal junction cancer. Read More

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https://www.futuremedicine.com/doi/10.2217/fon-2018-0609
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http://dx.doi.org/10.2217/fon-2018-0609DOI Listing
February 2019
4 Reads

Impact of isolated tumor cells in regional lymph nodes in adeno-and squamous cell carcinoma of the esophagus and the esophagogastric junction-A systematic review.

Pathol Res Pract 2019 Jan 30. Epub 2019 Jan 30.

Department of Surgical Gastroenterology Rigshospitalet, Copenhagen University Hospital, Inge Lehmanns Vej 7, 2100, Copenhagen Ø, Denmark.

Background/introduction: Isolated tumor cells (ITC) are tumor cells identified in the regional lymph nodes of patients with adeno- or squamous cell carcinoma of the esophagogastric junction (EGJ) or the esophagus. The current staging guidelines for these cancers do not assign any prognostic relevance to ITC, but their role remains debatable. We evaluated current literature to provide an overview of the prognostic relevance of ITC in regional lymph nodes of patients diagnosed with node negative cancer of the esophagus and EGJ. Read More

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http://dx.doi.org/10.1016/j.prp.2019.01.040DOI Listing
January 2019

A competing-risks nomogram and recursive partitioning analysis for cause-specific mortality in patients with esophageal neuroendocrine carcinoma.

Authors:
G Zhang B Wu X Wang J Li

Dis Esophagus 2019 Jan 31. Epub 2019 Jan 31.

Department of Thoracic Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.

The objective of this study is to estimate the probability of cause-specific mortality using a competing-risks nomogram and recursive partitioning analysis in a large population-based cohort of patients with esophageal neuroendocrine carcinoma. The surveillance, epidemiology and end results database was used to identify 162 patients diagnosed with esophageal neuroendocrine carcinoma from 1998 to 2014. We estimated a cumulative incidence function for cause-specific mortality. Read More

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http://dx.doi.org/10.1093/dote/doy129DOI Listing
January 2019

High miR-3687 Expression Affects Migratory and Invasive Ability of Oesophageal Carcinoma.

Anticancer Res 2019 Feb;39(2):557-565

First Department of Surgery, Faculty of Medicine University of Yamanashi, Yamanashi, Japan.

Background/aim: Basaloid squamous cell carcinoma of the oesophagus (BSCCE) is a variant of oesophageal squamous cell carcinoma (ESCC), that has a more aggressive biological behaviour than that of typical ESCC. miR-3687 has been previously identified to be highly expressed in BSCCE. This study aimed to evaluate the prognostic impact of miR-3687 in ESCC and determine the role of miR-3687 in ESCC motility. Read More

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http://dx.doi.org/10.21873/anticanres.13148DOI Listing
February 2019

High levels of RAI3 expression is linked to shortened survival in esophageal cancer patients.

Exp Mol Pathol 2019 Jan 29;107:51-56. Epub 2019 Jan 29.

General, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg-Eppendorf, Germany. Electronic address:

Expression of the retinoic acid-induced protein 3 (RAI3) has been suggested to predict clinical outcome in a variety of malignancies. However, its role in esophageal cancers remains unclear. Immunohistochemical RAI3 staining was analyzed on tissue microarrays containing 359 esophageal adenocarcinomas (EAC) and 254 esophageal squamous cell carcinomas (ESCC). Read More

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http://dx.doi.org/10.1016/j.yexmp.2019.01.013DOI Listing
January 2019

[Application of intracorporeal uncut Roux-en-Y anastomosis in digestive tract reconstruction after laparoscopic total gastrectomy].

Zhonghua Wei Chang Wai Ke Za Zhi 2019 Jan;22(1):43-48

Department of Oncology Surgery, Fujian Provincial Hospital, Fuzhou 350001,

Objective: To explore the safety, feasibility and short-term efficacy of intracavitary uncut Roux-en-Y (URY) anastomosis in digestive tract reconstruction following laparoscopic total gastrectomy (LTG).

Methods: From November 2015 to January 2018, 67 gastric cancer patients underwent intracavitary URY following LTG to reconstruct the digestive tract at Oncological Surgery Department of Fujian Provincial Hospital. There were 41 males and 26 females with age of 50 to 81 (61. Read More

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January 2019
1 Read

Does anti-reflux surgery disrupt the pathway of Barrett's esophagus progression to cancer?

Transl Gastroenterol Hepatol 2018 5;3:101. Epub 2018 Dec 5.

Reflux Medical, Vienna, Austria.

In patients with Barrett's esophagus (BE), anti-reflux surgery aims to sustainable control reflux symptoms and heal reflux induced esophageal mucosal inflammation and prevent progression of BE to adenocarcinoma. There is growing evidence that beside gastric acid, bile salts in refluxed duodenal juice are responsible for the development and progression of BE. However, the pathogenesis of BE progression and the metaplasia-dysplasia-carcinoma sequence of the adenocarcinoma of the esophagus (EAC) is multifactorial and occurs over long natural time course. Read More

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http://dx.doi.org/10.21037/tgh.2018.11.07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327172PMC
December 2018
7 Reads

Radiation With Neoadjuvant Chemotherapy Does Not Improve Outcomes in Esophageal Squamous Cell Cancer.

J Surg Res 2018 Dec 24;236:259-265. Epub 2018 Dec 24.

Department of Thoracic Surgery, Roswell Park Cancer Institute, Buffalo, New York. Electronic address:

Background: Neoadjuvant treatment improves survival for patients undergoing esophagectomy for esophageal cancer. Recent evidence suggests that neoadjuvant chemoradiation offers no advantage over chemotherapy alone before surgical resection for adenocarcinoma histology. We sought to examine if this applies to patients with squamous cell histology. Read More

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http://dx.doi.org/10.1016/j.jss.2018.11.052DOI Listing
December 2018
1.936 Impact Factor

[A Case of Successful Drainage for Mediastinitis during Chemotherapy for Unresectable Advanced Esophageal Cancer].

Gan To Kagaku Ryoho 2018 Dec;45(13):2402-2404

Dept. of Surgery, Kansai Rosai Hospital.

A 78-year-old man complained of dysphagia. Gastrointestinal endoscopy showed a Type 2 tumor in the lower esophagus and a Type 0-Ⅱa lesion in the posterior wall of the upper gastric body. An enhanced CT scan showed several swollen abdominal and cervical lymph nodes as well as bilateral lung multiple nodules, suggesting distant metastasis. Read More

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December 2018
5 Reads

[A Case of Esophageal Carcinoma with Large Intramural Metastasis to the Stomach].

Gan To Kagaku Ryoho 2018 Dec;45(13):2294-2296

Dept. of Surgery, Kansai Electric Power Hospital.

We report a rare case of esophageal carcinoma with gastric wall metastasis. A 73-year-old man with dysphagia underwent endoscopy and upper GI series and chest-abdominal computed tomography, revealing esophageal carcinoma and gastric cancer, which was diagnosed as squamous cell carcinoma by biopsy. The esophageal carcinoma was located in the lower thoracic esophagus(Lt). Read More

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December 2018
4 Reads

[Bevacizumab plus Paclitaxel Therapy Was Effective for Metastatic Breast Cancer with Dysphagia Due to Mediastinal Lymph Node Metastasis-A Case Report].

Gan To Kagaku Ryoho 2018 Dec;45(13):2276-2278

Dept. of Breast Surgery, Tokyo Women's Medical University Medical Center East.

A 69-year-old woman noticed a tumor of the right breast, and presented to our hospital with dysphagia. A tumor of size 10 cm exposed to the skin and swollen axillary lymph node were observed. She was diagnosed with invasive ductal carcinoma, luminal-B by core-needle biopsy. Read More

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December 2018
1 Read

A possible role of biogenic silica in esophageal cancer in North China?

Environ Sci Pollut Res Int 2019 Jan 28. Epub 2019 Jan 28.

School of Public Health, The University of Hong Kong, 7 Sassoon Road, Hong Kong, SAR, China.

Certain areas in North China have the highest incidence of esophageal squamous cell carcinoma (ESCC) in the world, which has not seen convincing explanation by any risk factor yet. Biogenic silica in millet bran was linked to ESCC in the early 1980s but the hypothesis was largely dismissed because of the lack of geographic correlation between millet consumption and ESCC. Later epidemiological studies disclosed the linkage of wheat consumption in North China to ESCC instead. Read More

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http://dx.doi.org/10.1007/s11356-019-04332-wDOI Listing
January 2019

Correction: .

Authors:

BMJ Open Gastroenterol 2018 30;5(1):e000232corr1. Epub 2018 Dec 30.

[This corrects the article DOI: 10.1136/bmjgast-2018-000232.]. Read More

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http://dx.doi.org/10.1136/bmjgast-2018-000232corr1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326290PMC
December 2018

Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid: Case report of a rare lesion with novel genetic mutation.

Diagn Cytopathol 2019 Jan 24. Epub 2019 Jan 24.

Department of Pathology, VCU School of Medicine, Richmond, Virginia.

Sclerosing mucoepidermoid carcinoma with eosinophilia (SMECE) is a rare primary cancer of the thyroid. This tumor is analogous to other primary tumors of the salivary glands, breast, pancreas, and esophagus. We present a case of this rare tumor with characteristic clinical features, ultrasound images, cytopathology, histopathology, and a heretofore undocumented somatic gene mutation. Read More

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http://dx.doi.org/10.1002/dc.24148DOI Listing
January 2019
1 Read

Narrow-Band Imaging: Clinical Application in Gastrointestinal Endoscopy.

GE Port J Gastroenterol 2018 Dec 27;26(1):40-53. Epub 2018 Mar 27.

Department of Gastroenterology, Instituto Português de Oncologia do Porto, Porto, Portugal.

Narrow-band imaging is an advanced imaging system that applies optic digital methods to enhance endoscopic images and improves visualization of the mucosal surface architecture and microvascular pattern. Narrow-band imaging use has been suggested to be an important adjunctive tool to white-light endoscopy to improve the detection of lesions in the digestive tract. Importantly, it also allows the distinction between benign and malignant lesions, targeting biopsies, prediction of the risk of invasive cancer, delimitation of resection margins, and identification of residual neoplasia in a scar. Read More

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https://www.karger.com/Article/FullText/487470
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http://dx.doi.org/10.1159/000487470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341367PMC
December 2018
6 Reads

Effect of STAT3 decoy oligodeoxynucleotides mediated by ultrasound-targeted microbubbles combined with ultrasound on the growth of squamous cell carcinoma of the esophagus.

Oncol Lett 2019 Feb 10;17(2):2151-2158. Epub 2018 Dec 10.

Department of Gastrointestinal and Minimally Invasive Surgery, Ningbo No. 2 Hospital, Ningbo, Zhejiang 315010, P.R. China.

Effect of STAT3 decoy oligodeoxynucleotides (ODN) transduced by ultrasound microbubbles combined with ultrasound on the growth of esophageal squamous cell carcinoma and its mechanism were analyzed. EC9706 cells were cultured in vitro and divided into four groups: group E (ultrasound microbubble + ultrasound irradiation), group P (liposome + ultrasound irradiation), group C (ultrasound), and group CC (ultrasound microbubbles). Mutant ODNs were used in groups E and P and the control group was group EC and PC, respectively. Read More

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http://www.spandidos-publications.com/10.3892/ol.2018.9814
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http://dx.doi.org/10.3892/ol.2018.9814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341804PMC
February 2019
6 Reads

Possible role of in orodigestive cancers.

J Oral Microbiol 2019 9;11(1):1563410. Epub 2019 Jan 9.

Department of Oral Health Sciences, Medical University of South Carolina, Charleston, SC, USA.

There is increasing evidence for an association between periodontitis/tooth loss and oral, gastrointestinal, and pancreatic cancers. Periodontal disease, which is characterized by chronic inflammation and microbial dysbiosis, is a significant risk factor for orodigestive carcinogenesis. is proposed as a keystone pathogen in chronic periodontitis causing both dysbiosis and discordant immune response. Read More

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http://dx.doi.org/10.1080/20002297.2018.1563410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327928PMC
January 2019
1 Read

The role of photodynamic therapy in the treatment of esophageal cancer.

Dig Endosc 2019 Jan 22. Epub 2019 Jan 22.

Department of Gastroenterology and Endoscopy, National Cancer Center Hospital East, Kashiwa, Japan.

Photodynamic therapy (PDT), a treatment of choice for cancer, induce photochemical reaction, thereby eradicating tumor cells. This is achieved through the administration of a photosensitizer drug, which is activated with a laser after localization to the tumor mass, and is an approved curative endoscopic ablative treatment for superficial esophageal squamous cell carcinoma (ESCC) in Japan. PDT has been approved for dysplastic Barrett 's esophagus and as a palliative treatment for patients with symptomatic obstructive esophageal cancer in US. Read More

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http://dx.doi.org/10.1111/den.13353DOI Listing
January 2019
2 Reads

Response.

Gastrointest Endosc 2019 02;89(2):444

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.

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http://dx.doi.org/10.1016/j.gie.2018.10.006DOI Listing
February 2019

Screening for esophageal squamous cell carcinoma: insight from experience with Barrett's esophagus.

Gastrointest Endosc 2019 02;89(2):443-444.e1

Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai, China.

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http://dx.doi.org/10.1016/j.gie.2018.09.019DOI Listing
February 2019

Neoadjuvant Chemoradiation Treatment for Resectable Esophago-Gastric Cancer: A Systematic Review and Meta-Analysis.

J Cancer 2019 1;10(1):192-204. Epub 2019 Jan 1.

Department of Gastric Surgery, Cancer Hospital of China Medical University/Liaoning Cancer Hospital, Shenyang, Liaoning, China.

Neoadjuvant chemoradiation (CRT) remains controversial in the treatment of the oesophagus or gastro-oesophageal junction (GOJ) carcinomas. We conducted a meta-analysis to assess the efficacy and safety of Neoadjuvant CRT plus surgery comparing with neoadjuvant CT plus surgery or surgery alone. Feasible studies were searched from electronic databases. Read More

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http://www.jcancer.org/v10p0192.htm
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http://dx.doi.org/10.7150/jca.25915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329872PMC
January 2019
2 Reads

REV7 confers radioresistance of esophagus squamous cell carcinoma by recruiting PRDX2.

Cancer Sci 2019 Jan 18. Epub 2019 Jan 18.

State Key Lab of Radiation Medicine and Protection, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, China.

Radiotherapy has been widely used for the clinical management of esophageal squamous cell carcinoma. However, radioresistance remains a serious concern that prevents the efficacy of esophageal squamous cell carcinoma (ESCC) radiotherapy. REV7, the structural subunit of eukaryotic DNA polymerase ζ, has multiple functions in bypassing DNA damage and modulating mitotic arrest in human cell lines. Read More

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http://doi.wiley.com/10.1111/cas.13946
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http://dx.doi.org/10.1111/cas.13946DOI Listing
January 2019
11 Reads

Esophageal Squamous Cell Carcinoma After Adjustable Gastric Banding.

Obes Surg 2019 Jan 18. Epub 2019 Jan 18.

GZA Hospitals, Antwerp, Belgium.

The prevalence of morbid obesity has been increasing worldwide. Therefore, multiple laparoscopic adjustable gastric bandings (LAGBs) have been placed in Belgium in the nineties. The procedure was considered as minimal invasive with low morbidity rates. Read More

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http://dx.doi.org/10.1007/s11695-019-03708-8DOI Listing
January 2019
1 Read

Carcinosarcoma of the esophagus: A report of 6 cases associated with zinc finger E-box-binding homeobox 1 expression.

Oncol Lett 2019 Jan 16;17(1):578-586. Epub 2018 Oct 16.

Department of Surgery, Kitasato University School of Medicine, Sagamihara, Kanagawa 252-0375, Japan.

Esophageal carcinosarcoma (ECS) has been suggested to result from an epithelial mesenchymal transition (EMT) phenomenon. However, knowledge on its underlying molecular features is limited. The clinical and pathological features, and the prognosis of ECS require further investigation. Read More

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http://dx.doi.org/10.3892/ol.2018.9585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313136PMC
January 2019

Effect of pemetrexed on brain metastases from nonsmall cell lung cancer with wild-type and unknown EGFR status.

Authors:
Xiaoqing Yu Yun Fan

Medicine (Baltimore) 2019 Jan;98(3):e14110

Technology on Thoracic Oncology (Esophagus, Lung), Zhejiang Cancer Hospital, Hangzhou, Zhejiang, People's Republic of China.

We aimed to evaluate the effectiveness of pemetrexed-based chemotherapy in wild-type nonsmall-cell lung cancer (NSCLC) patients with brain metastases (BM). Brain metastases are a common cause of mortality in NSCLC patients. For epidermal growth factor receptor (EGFR) wild-type patients, therapeutic options for BM are even limited. Read More

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http://dx.doi.org/10.1097/MD.0000000000014110DOI Listing
January 2019
1 Read

Tetrahydrocurcumin, Curcumin, and 5-Fluorouracil Effects on Human Esophageal Carcinoma Cells.

Anticancer Agents Med Chem 2019 Jan 16. Epub 2019 Jan 16.

Department of Biological Sciences, Bowling Green State University, Bowling Green, OH. United States.

Background: Esophageal cancer responds poorly to traditional therapies, and novel treatments are needed. The phytochemical curcumin is a potential treatment for esophageal squamous cell carcinoma (ESCC). A curcumin metabolite, tetrahydrocurcumin (THCUR), has anti-cancer effects and greater bioavailability than curcumin. Read More

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http://dx.doi.org/10.2174/1871520619666190116141448DOI Listing
January 2019
7 Reads

Survival of patients with head and neck cancer with metachronous multiple primary tumors is surprisingly favorable.

Head Neck 2019 Jan 16. Epub 2019 Jan 16.

Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.

Background: The objectives of this study are to determine the incidence and survival rate of patients with head and neck squamous cell carcinoma (HNSCC) with multiple primary tumors (MPT) in the HN-region, lung, or esophagus.

Methods: Patient and tumor specific data of 1372 patients with HNSCC were collected from both the national cancer registry and patient records to ensure high-quality double-checked data.

Results: The total incidence of MPTs in the HN-region, lung, and esophagus in patients with HNSCC was 11% (149/1372). Read More

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http://doi.wiley.com/10.1002/hed.25595
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http://dx.doi.org/10.1002/hed.25595DOI Listing
January 2019
4 Reads

SMARCB1- and vimentin-positive esophageal carcinoma with undifferentiated components, rhabdoid features, and a good prognosis: a case report.

Surg Case Rep 2019 Jan 16;5(1). Epub 2019 Jan 16.

1st Department of Surgery, Faculty of Medicine, University of Fukui, 23-3 Matsuokashimoaizuki, Yoshida-gun, Eiheiji-cho, Fukui, 910-1193, Japan.

Background: Undifferentiated carcinoma of the esophagus with rhabdoid features is a very rare histologic finding that is occasionally associated with the loss of SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1); however, until now, few survey reports of this type of tumor have been published. In this study, we describe a case of esophageal carcinoma with undifferentiated components and rhabdoid features that was exclusively positive for vimentin and SMARCB1 in a patient with prolonged survival.

Case Presentation: A 67-year-old man complained of a stomachache and loss of appetite persisting for 1 month. Read More

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https://surgicalcasereports.springeropen.com/articles/10.118
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http://dx.doi.org/10.1186/s40792-019-0562-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335233PMC
January 2019
2 Reads

Assessing Microcirculation in Resectable Oesophageal Squamous Cell Carcinoma with Dynamic Contrast-enhanced MRI for Identifying Primary tumour and Lymphatic Metastasis.

Sci Rep 2019 Jan 15;9(1):124. Epub 2019 Jan 15.

Sichuan Key Laboratory of Medical Imaging, and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, 63# Wenhua Road, Nanchong, Sichuan, China.

This study aimed to determine whether dynamic contrast-enhanced MRI (DCE-MRI) derived parameters can identify oesophageal squamous cell carcinoma (SCC) and lymphatic metastasis. Thirty-nine oesophageal SCC patients underwent DCE-MRI. Quantitative parameters including endothelial transfer constant (K), reflux rate (K), fractional extravascular extracellular space volume and fractional plasma volume, and semi-quantitative parameters including time to peak (TTP), max concentration, Max Slope and area under concentration-time curve of both oesophageal SCC and normal oesophagus were measured. Read More

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http://dx.doi.org/10.1038/s41598-018-36929-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333778PMC
January 2019

[Management of clinical cT2N0 carcinoma of the esophagus].

Chirurg 2019 Feb;90(2):156

Klinik für Allgemein‑, Viszeral- und Tumorchirurgie, Universitätsklinik Köln, Kerpener Str. 62, 50937, Köln, Deutschland.

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http://dx.doi.org/10.1007/s00104-019-0796-5DOI Listing
February 2019

Analysis of SPARC and TUBB3 as predictors for prognosis in esophageal squamous cell carcinoma receiving nab-paclitaxel plus cisplatin neoadjuvant chemotherapy: a prospective study.

Cancer Chemother Pharmacol 2019 Jan 14. Epub 2019 Jan 14.

Department of Thoracic Medical Oncology, Zhejiang Cancer Hospital, Hangzhou, People's Republic of China.

Purpose: The purpose of the study is to evaluate the predictive efficacy of secreted protein, acidic and rich in cysteine (SPARC) and the class III β-tubulin (β-tubulin III, TUBB3) in predicting therapeutic effect in patients with locally advanced esophageal squamous cell carcinoma(ESCC) who received nab-paclitaxel plus cisplatin neoadjuvant chemotherapy(CT) followed by surgery.

Methods: Patients with stage II to III esophageal squamous cell carcinoma of different stages are recruited. The tumor biopsy tissues prior treatment from enrolled patients were examined by SPARC and TUBB3 immunohistochemistry (IHC). Read More

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http://link.springer.com/10.1007/s00280-019-03769-7
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http://dx.doi.org/10.1007/s00280-019-03769-7DOI Listing
January 2019
3 Reads

Esophageal Basaloid Squamous Carcinoma Treated by Endoscopic Resection and Radiation.

Korean J Gastroenterol 2018 Nov;72(5):258-261

Department of Pathology, Yeungnam University College of Medicine, Daegu, Korea.

Esophageal basaloid squamous carcinoma (BSC) is a rare, aggressive variant of squamous cell carcinoma. BSC is usually diagnosed in advanced stage and its prognosis is relatively poor. A 59-year-old male with subepithelial lesion of the esophagus that was incidentally discovered during health promotion examination was referred to our hospital. Read More

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http://dx.doi.org/10.4166/kjg.2018.72.5.258DOI Listing
November 2018
2 Reads

Neoadjuvant chemoradiation for patients with advanced esophageal cancer- Which response grading system best impacts prognostic discrimination?

Histopathology 2019 Jan 12. Epub 2019 Jan 12.

Institute of Pathology, University of Cologne, Cologne, Germany.

Aim: Neoadjuvant chemoradiation reduces tumor volume and improves R0 resection rate, followed by extended survival for patients with advanced esophageal cancer. The degree of tumor regression has high prognostic relevance. To date, there is still no generally accepted tumor regression grading system. Read More

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http://dx.doi.org/10.1111/his.13811DOI Listing
January 2019

Primary amelanotic malignant melanoma of the esophagus: a case report.

Surg Case Rep 2019 Jan 11;5(1). Epub 2019 Jan 11.

Kyushu Central Hospital of the Mutual Aid Association of Public School Teachers, 3-23-1, Shiobaru, Minami-ku, Fukuoka, 815-8588, Japan.

Background: Primary amelanotic malignant melanoma of esophagus, which is a subtype of primary malignant melanoma of the esophagus (PMME), is a very rare disease with a poor prognosis. We herein report a case of the amelanotic type of PMME.

Case Presentation: An 86-year-old woman was admitted to our hospital with symptoms of dysphagia. Read More

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http://dx.doi.org/10.1186/s40792-019-0564-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329688PMC
January 2019
1 Read

A Case of Recurrent Esophageal Cancer Treated with Concurrent Chemoradiation Therapy in Pregnancy.

Case Rep Obstet Gynecol 2018 3;2018:1280582. Epub 2018 Dec 3.

Department of Gynecology and Obstetrics, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan.

Esophageal cancer rarely coincides with pregnancy, and only five cases have been reported thus far. The management of esophageal cancer during pregnancy is extremely challenging due to its aggressive nature. We herein report a case of recurrent esophageal cancer in pregnancy. Read More

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http://dx.doi.org/10.1155/2018/1280582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304601PMC
December 2018
1 Read

Liver Metastasis of Hepatoid Colonic Adenocarcinoma: A Rare and Unusual Entity With Poor Prognosis and Review of the Literature.

Gastroenterology Res 2018 Dec 17;11(6):430-435. Epub 2018 Dec 17.

Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.

Hepatoid adenocarcinoma (HAC) is rare and was first reported as α-fetoprotein (AFP)-producing tumor. It is an important variant of extrahepatic adenocarcinoma with clinicopathological presentation mimicking hepatocellular carcinoma and carries exceedingly poor prognosis. HAC most commonly originates in the stomach, and less commonly in the ovary, esophagus, lung, among other organs. Read More

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http://dx.doi.org/10.14740/gr1097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306111PMC
December 2018
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[Endocrine cell carcinoma of the esophagus without recurrence for more than 7 years after chemoradiotherapy].

Nihon Shokakibyo Gakkai Zasshi 2019 ;116(1):71-79

Department of Surgery, Tagawa Social Insurance Hospital.

We report a case of endocrine cell carcinoma (ECC) of the esophagus with long term survival after chemoradiotherapy. The patient had a complete response and remains without any recurrence. A 69-year-old woman visited our hospital because of progressive dysphagia. Read More

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http://dx.doi.org/10.11405/nisshoshi.116.71DOI Listing
January 2019

Hybrid Minimally Invasive Esophagectomy for Esophageal Cancer.

N Engl J Med 2019 01;380(2):152-162

From the Department of Digestive and Oncologic Surgery, Claude Huriez University Hospital, and INSERM, Centre Hospitalier Universitaire (CHU) Lille, Unité Mixte de Recherche 1172-JPARC Jean-Pierre Aubert Research Center, Team "Mucins, epithelial differentiation, and carcinogenesis," Université de Lille, Lille (C.M., G.P.), the Epidemiology and Quality of Life Unit, INSERM Unité 1231, Centre Georges François Leclerc, Dijon (T.S.D.-Y.), the Department of Hepatobiliary and Digestive Surgery, CHU Rennes, University of Rennes 1, Rennes (B.M.), Université Clermont Auvergne, INSERM, CHU Clermont-Ferrand, Service de Chirurgie Digestive, Clermont-Ferrand (D.P.), the Department of Digestive Surgery, Haut Lévèque University Hospital, Bordeaux (D.C.), the Department of Thoracic Surgery, Hôpital Nord, Aix-Marseille Université, Assistance Publique-Hôpitaux de Marseille, Marseille (X.B.D.), the Department of Digestive Surgery, Strasbourg University, Strasbourg (C.B.), the Department of Digestive Surgery, Institut Mutualiste Montsouris, Paris (T.P.), the Department of Digestive Surgery, Purpan Hospital, CHU Toulouse, Université Toulouse III, Toulouse (N.C.), the Department of General Surgery and Liver Transplantation, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Equipe Mixte de Recherche 3738, Université Lyon 1, Lyon (J.-Y.M.), the Department of Digestive and General Surgery, CHU Louis Mourier, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris 7, Denis Diderot, PRES Sorbonne Paris Cité, Colombes (S.M.), the Department of Surgery and Oncology, Centre Hospitalier Universitaire Ambroise Paré, AP-HP, Université de Versailles, Boulogne-Billancourt (F.P.), the Department of Digestive Surgery, CHU Nîmes, Nîmes (M.P.), and the Methodology and Quality of Life Unit in Cancer, INSERM Unité Mixte de Recherche 1098, University Hospital of Besançon, Besançon (F.B.) - all in France; and the Department of Surgery and Cancer, Imperial College, London (S.R.M.).

Background: Postoperative complications, especially pulmonary complications, affect more than half the patients who undergo open esophagectomy for esophageal cancer. Whether hybrid minimally invasive esophagectomy results in lower morbidity than open esophagectomy is unclear.

Methods: We performed a multicenter, open-label, randomized, controlled trial involving patients 18 to 75 years of age with resectable cancer of the middle or lower third of the esophagus. Read More

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http://www.nejm.org/doi/10.1056/NEJMoa1805101
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http://dx.doi.org/10.1056/NEJMoa1805101DOI Listing
January 2019
5 Reads

Gastroesophageal junction Paneth cell carcinoma with extensive cystic and secretory features - case report and literature review.

Diagn Pathol 2019 Jan 8;14(1). Epub 2019 Jan 8.

Department of Pathology, MD Anderson Cancer Center, Houston, USA.

Background: Carcinomas composed predominantly or purely of malignant Paneth cells were rarely reported in gastrointestinal system. They have not been reported at gastroesophageal junction nor has the association with Barrett esophagus been explored. None of the previous studies has mentioned any peculiar histologic features other than typical adenocarcinoma containing neoplastic Paneth cells. Read More

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http://dx.doi.org/10.1186/s13000-018-0775-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323739PMC
January 2019
2 Reads

Possible biomarkers for predicting lymph node metastasis of esophageal squamous cell carcinoma: a review.

J Int Med Res 2019 Feb 7;47(2):544-556. Epub 2019 Jan 7.

1 Department of Radiotherapy, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, P. R. China.

Esophageal cancer is the eighth most common form of cancer worldwide, and esophageal squamous cell carcinoma (ESCC) is a major type of esophageal cancer that arises from epithelial cells of the esophagus. Local lymph node metastasis (LNM) is a typical sign of failure for ESCC clinical treatments, and a link has been established between LNM and the aberrant expression of specific biomarkers. In this review, we summarize what is known about nine factors significantly associated with LNM in ESCC patients: phosphatase and tensin homolog (PTEN), mucin 1, vascular endothelial growth factor-C, tumor necrosis factor alpha-induced protein 8 (TNFAIP8), Raf-1 kinase inhibitory protein, stathmin (STMN1), metastasis-associated protein 1, caveolin-1, and interferon-induced transmembrane protein 3. Read More

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http://journals.sagepub.com/doi/10.1177/0300060518819606
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http://dx.doi.org/10.1177/0300060518819606DOI Listing
February 2019
5 Reads

Influence of Treatment Caused Impairments on Anxiety and Depression in Patients with Cancer of the Esophagus or the Esophagogastric Junction.

J Gastrointest Cancer 2019 Jan 6. Epub 2019 Jan 6.

Department of Dermatology, University Medicine Greifswald, Greifswald, Germany.

Purpose: After therapy of cancer of the esophagus or the esophagogastric junction, patients often suffer from anxiety and depression. Some risk factors for elevated anxiety and depression are reported, but the influence of steatorrhea, the frequency of which has only recently been reported, has not yet been investigated.

Method: Using the Hospital Anxiety and Depression Scale (HADS), we analyzed the correlation of anxiety and depression with steatorrhea, appetite, and weight loss in 72 patients with cancer of the esophagus or of the esophagogastric junction, who were treated at our rehabilitation clinic between January 2011 and December 2014. Read More

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http://dx.doi.org/10.1007/s12029-018-00193-7DOI Listing
January 2019
1 Read