19,906 results match your criteria Esophagus Carcinoma


Shorter time to achieve endoscopic eradication is not associated with improved long-term outcomes in Barrett's esophagus.

Dis Esophagus 2019 Apr 17. Epub 2019 Apr 17.

Department of Medicine, Columbia University Medical Center, New York, USA.

Quality indicators have been proposed for endoscopic eradication therapy of Barrett's esophagus (BE). One such measure suggests that complete eradication of intestinal metaplasia (CE-IM) should be achieved within 18 months of starting treatment. The aim of this study was to assess whether achievement of CE-IM within 18 months is associated with improved long-term clinical outcomes. Read More

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http://dx.doi.org/10.1093/dote/doz026DOI Listing

Neoadjuvant versus definitive chemoradiation in patients with squamous cell carcinoma of the esophagus.

Radiat Oncol 2019 Apr 16;14(1):66. Epub 2019 Apr 16.

Department of Radiation Oncology, Klinikum rechts der Isar, Technical University Munich, Ismaninger Str. 22, 81675, Munich, Germany.

Background: Multimodal treatment with neoadjuvant chemoradiation followed by surgery (nCRT + S) is the treatment of choice for patients with locally advanced or node-positive esophageal squamous cell carcinoma (E-SCC). Those who are unsuitable or who decline surgery can be treated with definitive chemoradiation (dCRT). This study compares the oncologic outcome of nCRT + S and dCRT in E-SCC patients. Read More

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http://dx.doi.org/10.1186/s13014-019-1270-8DOI Listing

Prevalence and Associated Impacts of Cervical Esophageal Clearance Issues Post Chemoradiotherapy for Nasopharyngeal Carcinoma (NPC).

Dysphagia 2019 Apr 15. Epub 2019 Apr 15.

School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, QLD, Australia.

At present, the nature and extent of upper esophageal stage clearance issues following nonsurgical management of nasopharyngeal cancer (NPC) is not well elucidated. The aim of this study was to conduct an initial retrospective study of the prevalence and severity of upper esophageal clearance impairments in a cohort of patients post-NPC management. A secondary aim was to explore any observed relationship between severity of impairment with both (a) aspiration and (b) temporal oropharyngeal swallowing measures. Read More

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http://dx.doi.org/10.1007/s00455-019-10007-yDOI Listing

Tspan8 is expressed in breast cancer and regulates E-cadherin / catenin signalling and metastasis accompanied by increased circulating extracellular vesicles.

J Pathol 2019 Apr 14. Epub 2019 Apr 14.

Institute for Infection Prevention and Hospital Epidemiology; Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, 79106, Freiburg, Germany.

Tspan8 exhibits a functional role in many cancer types including pancreatic, colorectal, oesophagus carcinoma and melanoma. We present a first study on the expression and function of Tspan8 in breast cancer. Tspan8 protein was present in the majority of human primary breast cancer lesions and metastases in the brain, bone, lung, and liver. Read More

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http://dx.doi.org/10.1002/path.5281DOI Listing

Evaluation of the impact of psoas muscle index, a parameter of sarcopenia, in patients with esophageal squamous cell carcinoma receiving neoadjuvant therapy.

Esophagus 2019 Apr 12. Epub 2019 Apr 12.

Department of Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan.

Background: The impact of sarcopenia on digestive cancer is widely known. Muscle mass, defined as the psoas muscle index (PMI), is an important parameter of sarcopenia. However, the relationship between esophageal cancer and PMI has not been fully investigated, especially in patients receiving neoadjuvant therapy. Read More

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http://dx.doi.org/10.1007/s10388-019-00670-3DOI Listing

Comparison of long-term outcomes between esophagectomy and chemoradiotherapy after endoscopic resection of submucosal esophageal squamous cell carcinoma.

Dis Esophagus 2019 Apr 12. Epub 2019 Apr 12.

Department of Gastroenterological Surgery.

Esophagectomy represents the standard treatment strategy for superficial esophageal cancer diagnosed pathologically as submucosal disease (pT1b) following an endoscopic resection (ER). However, chemoradiotherapy (CRT) is expected to become an alternative treatment option. This study retrospectively compared the outcomes of patients who underwent ER of submucosal esophageal squamous cell carcinoma, and who received additional treatment in the form of surgery and CRT. Read More

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http://dx.doi.org/10.1093/dote/doz023DOI Listing

Intramucosal esophageal neuroendocrine carcinoma treated with endoscopic submucosal dissection and chemotherapy: a case report.

Dig Endosc 2019 Apr 12. Epub 2019 Apr 12.

Department of Gastroenterology, Osaka City University Graduate School of Medicine.

Esophageal neuroendocrine carcinoma (NEC) is rare and often progresses rapidly with poor prognoses . A 75-year-old woman showed a 20-mm reddish depressed lesion, with central elevation and apparent wall extensions in her middle thoracic esophagus on esophagogastroduodenoscopy (Fig 1A, B). This article is protected by copyright. Read More

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http://dx.doi.org/10.1111/den.13420DOI Listing

[Updated German S3 guidelines on esophageal cancer and supplements from a surgical perspective].

Chirurg 2019 Apr 11. Epub 2019 Apr 11.

Klinik für Innere Medizin, Klinikum Bremen-Ost, Bremen, Deutschland.

The updated German S3 guidelines recommend transthoracic subtotal esophagectomy with 2‑field lymphadenectomy for surgical treatment of esophageal cancer in patients with squamous cell carcinoma and adenocarcinoma of the esophagogastric (AEG type I) junction of the middle and lower third. For AEG type III transhiatal extended total gastrectomy with distal esophageal resection is favored. Patients with AEG type II can be treated by both procedures under the prerequisite that an R0 resection can be achieved. Read More

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http://dx.doi.org/10.1007/s00104-019-0954-9DOI Listing
April 2019
1 Read

Impact of tumor-infiltrating LAMP-3 dendritic cells on the prognosis of esophageal squamous cell carcinoma.

Esophagus 2019 Apr 9. Epub 2019 Apr 9.

Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Asahimachi 1-4-3, Abenoku, Osaka, Japan.

Background: Dendritic cells (DCs) are the most potent antigen-presenting cells to induce cytotoxic T lymphocytes in the tumor environment. After acquiring antigens, DCs undergo maturation and their expression of MHC and co-stimulation molecules are enhanced, along with lysosome-associated membrane glycoprotein 3 (LAMP-3), which is a specific marker of mature DCs. In general, mature DCs are usually considered to be immunostimulatory in the cancer microenvironment. Read More

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http://dx.doi.org/10.1007/s10388-019-00669-wDOI Listing
April 2019
0.741 Impact Factor

Frequent and Specific Involvement of Changes of the p16-RB Pathway in Esophageal Neuroendocrine Carcinoma.

Anticancer Res 2019 Apr;39(4):1927-1934

Department of Pathology and Laboratory Medicine, Showa University School of Medicine, Tokyo, Japan.

Aim: This study investigated the immunohistochemical expression of retinoblastoma (RB) protein and p16 protein in 10 neuroendocrine carcinomas (NECs), in comparison to two mixed-type NECs; 28 squamous cell carcinomas (SCCs), and 12 carcinosarcomas (CSs) from patients with esophageal cancer.

Materials And Methods: Immunohistochemical staining was performed using the avidin-biotin complex detection method. The staining was evaluated as diffusely positive, heterogeneous (in 5-95% of tumor cells), or diffusely negative. Read More

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http://dx.doi.org/10.21873/anticanres.13302DOI Listing
April 2019
3 Reads

Recurrence Following Anastomotic Leakage After Surgery for Carcinoma of the Distal Esophagus and Gastroesophageal Junction: A Systematic Review.

Anticancer Res 2019 Apr;39(4):1651-1660

General Surgery Unit, Department of Medical and Surgical Sciences and Translational Medicine, St. Andrea University Hospital, Sapienza University of Rome, Rome, Italy.

Background: Esophageal cancer is the ninth most common cancer. The only potentially curative treatment is surgical resection, which unfortunately is still associated with major complications, the most important being anastomotic leakage, currently with an overall rate of up to 26% morbidity. The aim of this systematic review was to evaluate the relationship between anastomotic leakage and recurrence of disease. Read More

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http://dx.doi.org/10.21873/anticanres.13270DOI Listing
April 2019
1.872 Impact Factor

Palliative interventions for patients with incurable locally advanced or metastatic thoracic esophageal carcinoma.

Esophagus 2019 Apr 4. Epub 2019 Apr 4.

Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Background: The aim of this study was to assess the clinical outcomes of palliative interventions for patients with incurable locally advanced or metastatic esophageal carcinoma.

Methods: A total of 131 patients with thoracic esophageal carcinoma who underwent palliative interventions were enrolled. Insertion of a self-expandable metallic stent (SEMS), tube enterostomy for enteral nutrition (EN), and palliative esophagectomy (PE) were performed in 38, 65, and 28 patients, respectively. Read More

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http://dx.doi.org/10.1007/s10388-019-00665-0DOI Listing
April 2019
2 Reads

Cervical Esophageal Cancers: Challenges and Opportunities.

Curr Oncol Rep 2019 Apr 4;21(5):46. Epub 2019 Apr 4.

Department of Radiation Oncology, Mount Sinai Beth Israel, Suite 4G, 10 Union Square East, New York, NY, USA.

Purpose Of The Review: Cervical esophageal cancers (CECs) are a rare subset of esophageal cancers that are distinct in their management and outcomes. This review explores current data on the optimal management of this disease.

Recent Findings: While outcomes for CEC have been suboptimal, several strategies have been proven beneficial in recent years. Read More

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http://dx.doi.org/10.1007/s11912-019-0801-7DOI Listing

Prognosis and prognostic factors of esophageal spindle cell carcinoma treated by esophagectomy: a retrospective single-institution analysis.

Esophagus 2019 Apr 1. Epub 2019 Apr 1.

Department of Surgery, Keiyukai Sapporo Hospital, Kita1-1, Hondori14-chome, Shiroishi-ku, Sapporo-City, Hokkaido, 003-0027, Japan.

Background: Esophageal spindle cell carcinoma (ESpCC) is a malignant tumor composed of sarcomatous components. ESpCC is treated as a squamous cell carcinoma. However, because ESpCC is a rare tumor, little is known regarding its prognosis. Read More

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http://dx.doi.org/10.1007/s10388-019-00667-yDOI Listing

Efficacy of novel sedation using the combination of dexmedetomidine and midazolam during endoscopic submucosal dissection for esophageal squamous cell carcinoma.

Esophagus 2019 Apr 1. Epub 2019 Apr 1.

Department of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31, Ariake, Koto-ku, Tokyo, 135-8550, Japan.

Background: Endoscopic submucosal dissection (ESD) is the preferred treatment for esophageal squamous cell carcinoma (ESCC). However, ESD can be difficult when patients move due to insufficient sedation. We conducted a prospective confirmatory single arm study to evaluate the efficacy of using dexmedetomidine (DEX) in combination with midazolam as a novel sedation for ESD. Read More

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http://dx.doi.org/10.1007/s10388-019-00666-zDOI Listing

Parathyroid carcinoma: a case report.

Exp Oncol 2019 Mar;41(1):72-75

State Scientific Institution "Scientific-Practical Centre of Preventive and Clinical Medicine", State Administration of Affairs, Kyiv, Ukraine.

Parathyroid carcinoma (PC) is an uncommon cause of primary hyperparathyroidism (pHPT). The tumor is mostly functioning with following high serum calcium and parathyroid hormone (PTH) levels. Consideration of PC in differential diagnosis of pHPT is important because the mortality and the prognosis depend on early recognition and surgical approach. Read More

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March 2019
1 Read

Treatment of high-grade dysplasia and intramucosal carcinoma using radiofrequency ablation or endoscopic mucosal resection + radiofrequency ablation: Meta-analysis and systematic review.

World J Gastrointest Endosc 2019 Mar;11(3):239-248

Gastrointestinal Endoscopy Unit, Gastroenterology Department, University of Sao Paulo School of Medicine, São Paulo, SP 05403-000, Brazil.

Background: The progression of Barrett's esophagus (BE) to early esophageal carcinoma occurs sequentially; the metaplastic epithelium develops from a low-grade dysplasia to a high-grade dysplasia (HGD), resulting in early esophageal carcinoma and, eventually, invasive carcinoma. Endoscopic approaches including resection and ablation can be used in the treatment of this condition.

Aim: To compare the effectiveness of radiofrequency ablation (RFA) endoscopic mucosal resection (EMR) + RFA in the endoscopic treatment of HGD and intramucosal carcinoma. Read More

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http://dx.doi.org/10.4253/wjge.v11.i3.239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425278PMC
March 2019
2 Reads

[A Case of Unresectable Advanced Esophageal Cancer Treated with Chemoradiotherapy Resulting in Complete Response].

Gan To Kagaku Ryoho 2019 Mar;46(3):529-531

Dept. of Gastrointestinal Surgery, Hyogo Prefectural Nishinomiya Hospital.

A70s man was admitted to our hospital complaining of chest discomfort. Endoscopic examination showed mucosal erythema and irregularity and an area unstained by iodine in the middle esophagus 21 to 41 cm from the incisors. The biopsy specimen showed moderately differentiated squamous cell carcinoma. Read More

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Risk of Lymph Node Metastasis in Patients with the Superficial Spreading Type of Esophageal Squamous Cell Carcinoma.

Digestion 2019 Mar 25:1-6. Epub 2019 Mar 25.

Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan.

Background: Little is known about the clinicopathological characteristics of superficial spreading-type esophageal carcinoma extending ≥5 cm along the long axis of the esophagus. This study was aimed at investigating the frequency of lymph node metastasis (LNM) in patients with superficial spreading-type esophageal carcinoma.

Methods: We reviewed the data of 320 patients with superficial esophageal squamous cell carcinoma who had undergone esophagectomy with lymph node dissection at our hospital between 1986 and 2010. Read More

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http://dx.doi.org/10.1159/000499017DOI Listing
March 2019
1 Read

Serum SCCA levels in patients suffering cancers or other diseases.

Prog Mol Biol Transl Sci 2019 9;162:165-175. Epub 2019 Mar 9.

Systems Biology and Medicine Center for Complex Diseases, Affiliated Hospital of Qingdao University, Qingdao, China. Electronic address:

Increased serum squamous cell carcinoma antigen (SCCA) levels are clinically used diagnostic or prognostic biomarker for squamous cell carcinomas. According to recently published studies, increased serum SCCA levels are also observed in adenocarcinomas, hepatocarcinomas, kidney, and other inflammatory diseases, indicating squamous cell carcinoma is not the production source of serum SCCA in these diseases. However, serum SCCA levels in patients suffering different types of diseases have not been systematically measured and compared. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18771173183015
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http://dx.doi.org/10.1016/bs.pmbts.2018.12.004DOI Listing
March 2019
6 Reads

A new step for volumetric laser endomicroscopy: entering the therapeutic realm of endoscopic mucosal resection.

Gastrointest Endosc 2019 04;89(4):709-711

Department of Anatomic Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.

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http://dx.doi.org/10.1016/j.gie.2018.12.020DOI Listing

Randomized studies for Barrett's ablation: just because we can doesn't mean we should.

Gastrointest Endosc 2019 04;89(4):690-692

Department of Gastroenterology and Hepatology, Amsterdam University Medical Center, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1016/j.gie.2018.11.007DOI Listing

A BAFfling liver aspirate: Metastatic high grade SMARCA4 deficient undifferentiated gastroesophageal junction carcinoma masquerading as a hematolymphoid malignancy.

Diagn Cytopathol 2019 Mar 21. Epub 2019 Mar 21.

Department of Pathology, Loyola University Medical Center, Maywood, Illinois.

Undifferentiated malignant SMARCA4-deficient neoplasms are rare, recently characterized, high grade, potentially lethal malignancies. Such tumors are characterized by the loss of BRG1 encoded by SMARCA4, a key component of the Switch/Sucrose Non-Fermenting (SWI/SNF) chromatin remodeling complex. As this complex, also referred as BAF (BRG1/BRM associated factors) complex, is involved in the epigenetic control of hundreds of genes, including those involved in lineage-specific differentiation, BAF-deficient tumors, show minimal or no differentiation and are difficult to classify. Read More

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http://dx.doi.org/10.1002/dc.24174DOI Listing
March 2019
2 Reads

Case 268.

Radiology 2019 Apr;291(1):259-260

From the Department of Radiology, Norfolk and Norwich University Hospitals, Colney Lane, Norwich NR4 7UY, England.

History A 65-year-old man presented to the emergency department with a 1-week history of constipation, which was associated with increasing abdominal distention and not passing flatus. Four weeks prior to the current admission he had been diagnosed with metastatic primary adenocarcinoma of the appendix. One week ago, he had been hospitalized with small-bowel obstruction, for which he required laparotomy and loop ileostomy. Read More

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http://dx.doi.org/10.1148/radiol.2019170367DOI Listing
April 2019
2 Reads

Discovery of a Novel Connecting Link between Renin-Angiotensin System and Cancer in Barrett's Esophagus by Proteomic Screening.

Proteomics Clin Appl 2019 Mar 19:e1900006. Epub 2019 Mar 19.

School of Life & Allied Health Sciences, The Glocal University, Saharanpur, 247121, Uttar Pradesh, India.

The renin-angiotensin system (RAS) plays a central role in the regulation of homeostasis and blood pressure. This involves an important enzyme called angiotensin-converting enzyme that leads to the conversion of angiotensin I into angiotensin II. RAS has been reported to show association with inflammation, and in sporadic studies, with cancer. Read More

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http://dx.doi.org/10.1002/prca.201900006DOI Listing
March 2019
1 Read

Metastases of ductal carcinoma of the breast in the esophagus. Case report

Rev Med Inst Mex Seguro Soc 2019 Mar 15;56(6):562-565. Epub 2019 Mar 15.

Instituto Mexicano del Seguro Social, Hospital de Especialidades “Dr. Bernardo Sepúlveda Gutiérrez, Servicio de Anatomía Patológica. Ciudad de México, México

Background: Invasive breast cancer is the most common carcinoma in women, 23% of all cancers in the world. It is classified according to its histological pattern and expression of immunohistochemical markers; 75% are ductal type. The incidence of metastases is 10 to 80% of the cases according to their immunophenotype, the main sites of metastases are bone, visceral and brain. Read More

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March 2019
5 Reads

Office-Based Cricopharyngeus Balloon Dilation for Post Chemoirradiation Dysphagia in Nasopharyngeal Carcinoma Patients: A Pilot Study.

Dysphagia 2019 Mar 19. Epub 2019 Mar 19.

Department of Ear, Nose & Throat, Queen Mary Hospital, Hong Kong SAR, China.

Dysphagia is a common sequela post chemo/radiotherapy for nasopharyngeal carcinoma (NPC), with cricopharyngeal dysfunction often a contributing factor. This study examined the impact of balloon dilation of the cricopharyngeus and cervical oesophagus on swallow competence for dysphagic patients with cricopharyngeal dysfunction post NPC. Patients with NPC were screened for dysphagia and cricopharyngeal dysfunction using fiberoptic endoscopic evaluation. Read More

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http://link.springer.com/10.1007/s00455-019-10002-3
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http://dx.doi.org/10.1007/s00455-019-10002-3DOI Listing
March 2019
7 Reads

Factors associated with overall survival and relief of dysphagia in advanced esophageal cancer patients after 125I seed-loaded stent placement: a multicenter retrospective analysis.

Dis Esophagus 2019 Mar 19. Epub 2019 Mar 19.

Center of Interventional Radiology and Vascular Surgery, Department of Radiology.

Iodine-125 (125I) seed-loaded stent placement has served as an effective palliation for malignant esophageal strictures in China. We performed a retrospective study to identify the prognostic factors of this irradiation stent placement in advanced esophageal cancer patients. A total of 201 patients who underwent 125I seed-loaded stent placement were included in this study from June 2012 to March 2016 at five hospitals in China. Read More

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https://academic.oup.com/dote/advance-article/doi/10.1093/do
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http://dx.doi.org/10.1093/dote/doz012DOI Listing
March 2019
7 Reads

Prognostic impact of lymphovascular invasion in lymph node-negative superficial esophageal squamous cell carcinoma.

Dis Esophagus 2019 Mar 18. Epub 2019 Mar 18.

Department of Pathology, Tokai University School of Medicine, Kanagawa, Japan.

The relationship between lymphovascular invasion (LVI) and prognosis in patients with superficial esophageal squamous cell carcinoma (SESCC) is unclear. The aim of this study is to evaluate prognostic factors in patients with lymph node-negative SESCC. A total of 195 patients with pathologically confirmed T1a-MM, T1b, and lymph node-negative SESCC were retrospectively reviewed in this study. Read More

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http://dx.doi.org/10.1093/dote/doz001DOI Listing

Resection of Mucosal and Submucosal Gastrointestinal Lesions and a Double Endoscope Experience.

JSLS 2019 Jan-Mar;23(1)

Istanbul Training and Research Hospital, Department of General Surgery, Fatih, Istanbul, Turkey.

Aim: The patients who underwent endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) for mucosal and submucosal lesions of the esophagus, stomach, and duodenum and the advantages of the double endoscope method we used for traction during ESD were evaluated.

Material And Methods: The patients who underwent ESD and EMR due to upper gastrointestinal lesions were evaluated retrospectively between January 2014 and April 2018 in our endoscopy unit.

Result: The mean age of 10 patients with esophageal lesions was 53 years. Read More

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http://dx.doi.org/10.4293/JSLS.2018.00096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408942PMC
March 2019
1 Read

Successful definitive concurrent chemoradiotherapy in a patient with esophageal cancer and Child-Pugh B cirrhosis of the liver.

J Cancer Res Ther 2019 Jan-Mar;15(1):255-257

Department of Radiology, The University of Tokyo Hospital, Tokyo, Japan.

This case report demonstrates successful concurrent chemoradiotherapy for esophageal cancer without severe adverse events in a patient with cirrhotic disease. A 63-year-old Japanese male with alcoholic liver cirrhosis was referred to our hospital for treatment of superficial esophageal cancer. Endoscopic submucosal dissection was performed and the patient was diagnosed as having squamous cell carcinoma of the esophagus that was pathologically staged as pT1bN0M0. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_338_17DOI Listing

Various addiction patterns, dietary habits, associated medical problems, and socioeconomic status in gastrointestinal malignancies: A prospective study in rural area of Maharashtra, India.

J Cancer Res Ther 2019 Jan-Mar;15(1):104-107

Department of Radiotherapy and Oncology, Rural Medical College, Pravara Institute of Medical Sciences, Ahmednagar, Maharashtra, India.

Background: Gastrointestinal (GI) malignancies are increasing with advancing age. Various addictions and poor dietary habits are among the major risk factors. Early detection is difficult until patient notices symptoms. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_925_17DOI Listing
March 2019
3 Reads

Barrett's Esophagus and Esophageal Carcinoma: Can Biomarkers Guide Clinical Practice?

Curr Gastroenterol Rep 2019 Mar 12;21(4):14. Epub 2019 Mar 12.

Department of Medicine and the Center for Esophageal Diseases, Baylor University Medical Center, Dallas, TX, 75246, USA.

Purpose Of Review: Despite gastrointestinal societal recommendations for endoscopic screening and surveillance of Barrett's esophagus, the rates of esophageal adenocarcinoma continue to rise. Furthermore, this current practice is costly to patients and the medical system without clear evidence of reduction in cancer mortality. The use of biomarkers to guide screening, surveillance, and treatment strategies might alleviate some of these issues. Read More

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http://dx.doi.org/10.1007/s11894-019-0685-6DOI Listing
March 2019
2 Reads

Association of a Genetic Variant in ATP-binding Cassette Sub-Family B Member 1 Gene with Poor Prognosis in Patients with Squamous Cell Carcinoma of the Esophagus.

IUBMB Life 2019 Mar 13. Epub 2019 Mar 13.

Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran.

Esophageal cancer is a common cause of death from cancer in men and the eighth most prevalent cancer globally. The morbidity and mortality rates are four times higher in men than in women. Genetic factors are among the susceptibility factors for squamous cell carcinoma of the esophagus. Read More

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http://dx.doi.org/10.1002/iub.2034DOI Listing
March 2019
1 Read

[The expressions and diagnostic values of miR-18a and miR-21 in esophageal cancer].

Zhonghua Zhong Liu Za Zhi 2019 Feb;41(2):107-111

Department of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College/Department of Laboratory Medicine, North Sichuan Medical College, Nanchong 637000, China.

To investigate the expressional levels and diagnostic values of miR-18a and miR-21 in esophageal carcinoma. The expressions of miR-18a and miR-21 in esophageal cancer tissues and adjacent tissues from 45 esophageal cancer patients, peripheral blood from 45 esophageal cancer patients and 50 healthy donors respectively were detected by RT-PCR. The expressions of miR-18a and miR-21 in normal esophageal epithelial cell HET-1A, esophageal cancer cell lines including ECA109, KYSE150 and TE1 were also detected. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-3766.2019.02.006DOI Listing
February 2019
2 Reads

Repression of AXL expression by AP-1/JNK blockage overcomes resistance to PI3Ka therapy.

JCI Insight 2019 Mar 12;5. Epub 2019 Mar 12.

AXL overexpression is a common resistance mechanism to anti-cancer therapies, including the resistance to BYL719 (Alpelisib) - the p110α isoform specific inhibitor of phosphoinositide 3-kinase (PI3K) - in esophagus and head and neck squamous cell carcinoma (ESCC, HNSCC respectively). However, the mechanisms underlying AXL overexpression in resistance to BYL719 remain elusive. Here we demonstrated that the AP-1 transcription factors, c-JUN and c-FOS, regulate AXL overexpression in HNSCC and ESCC. Read More

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http://dx.doi.org/10.1172/jci.insight.125341DOI Listing
March 2019
1 Read

Malignant melanoma of the esophagus complicated with poorly differentiated mucinous adenocarcinoma of the stomach: A case report.

Medicine (Baltimore) 2019 Mar;98(10):e14783

Department of Gastroenterology.

Rationale: Primary malignant melanoma of the esophagus (PMME) is a rare malignancy that only accounts for <2% of all primary esophageal tumors. Here, we report the even rarer occurrence of PMME in combination with poorly differentiated mucinous adenocarcinoma of the stomach.

Patient Concerns: A 64-year-old man was presented to the hospital with >1 month of eating dysphagia. Read More

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http://dx.doi.org/10.1097/MD.0000000000014783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417549PMC
March 2019
1 Read

Randomized phase II trial comparing tumor bed alone with tumor bed and elective nodal postoperative radiotherapy in patients with locoregionally advanced thoracic esophageal squamous cell carcinoma.

Dis Esophagus 2019 Mar 11. Epub 2019 Mar 11.

Department of Radiation Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University.

This study compares the outcomes of different postoperative radiation fields for locoregionally advanced thoracic esophageal squamous cell carcinoma (ESCC) patients. This is a multi-institution randomized phase II trial and noninferior study. Patients with ESCC who had undergone esophagectomy (stage T3-4N0-3M0) were enrolled and randomized into the large-field irradiation arm (LFI; tumor bed and elective lymph node region) and small-field irradiation arm (SFI; tumor bed only). Read More

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http://dx.doi.org/10.1093/dote/doz013DOI Listing
March 2019
7 Reads

Identifying the differentially expressed microRNAs in esophagus squamous cell carcinoma of Kazakh patients in Xinjiang.

Oncol Lett 2019 Mar 8;17(3):2657-2668. Epub 2019 Jan 8.

Department of Digestion, The First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi, Xinjiang 832000, P.R. China.

Despite improvements in diagnosis and treatment, the survival of patients with advanced stages of esophageal squamous cell carcinoma (ESCC) remains poor. Therefore, novel biomarkers that can assist with early detection of ESCC are required. In the present study, three paired ESCC and normal esophageal tissue samples from Xinjiang Kazakh patients were obtained and microRNA (miRNA) microarray analysis was used to detect the differentially-expressed miRNAs. Read More

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http://dx.doi.org/10.3892/ol.2019.9904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365931PMC

ΔNp63 in squamous cell carcinoma: defining the oncogenic routes affecting epigenetic landscape and tumour microenvironment.

Mol Oncol 2019 Mar 7. Epub 2019 Mar 7.

National Research Council of Italy, Institute of Translational Pharmacology, Rome, Italy.

Squamous cell carcinoma (SCC) is a treatment-refractory tumour which arises from the epithelium of diverse anatomical sites such as oesophagus, head and neck, lung and skin. Accumulating evidence has revealed a number of genomic, clinical and molecular features commonly observed in SCC of distinct origins. Some of these genetic events culminate in fostering the activity of ΔNp63, a potent oncogene which exerts its pro-tumourigenic effects by regulating specific transcriptional programmes to sustain malignant cell proliferation and survival. Read More

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http://dx.doi.org/10.1002/1878-0261.12473DOI Listing
March 2019
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Early Recurrence and Cancer Death After Trimodal Therapy for Esophageal Squamous Cell Carcinoma.

Anticancer Res 2019 Mar;39(3):1433-1440

Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.

Background/aim: Although locally advanced esophageal squamous cell carcinoma (ESCC) can be controlled and survival can be prolonged by neoadjuvant chemoradiotherapy (NCRT) followed by surgery (trimodal therapy), some patients still develop early recurrence and die of cancer even after such intensive therapy. The present study aimed to determine the factors associated with early recurrence and cancer death for patients with ESCC treated by trimodal therapy.

Patients And Methods: We evaluated risk factors for recurrence within 6 months, as well as cancer death within 1 year based on data from 141 patients with ESCC who underwent NCRT followed by curative esophagectomy. Read More

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http://dx.doi.org/10.21873/anticanres.13259DOI Listing
March 2019
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Increase of CD45-positive Immune Cells in Liver Parenchyma Indicates a More Favorable Prognosis for Patients With Barrett's Cancer.

Anticancer Res 2019 Mar;39(3):1191-1196

Department of General, Visceral and Thoracic Surgery, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany

Background: Despite advances in perioperative management, the 5-year survival rate of patients with esophageal adenocarcinoma (Barrett's cancer) is poor. Adjuvant immunotherapies are currently the subject of clinical trials. The prognostic role of tumor-infiltrating T-lymphocytes (TILs) expressing CD45 has only been investigated in primary tumors. Read More

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http://dx.doi.org/10.21873/anticanres.13229DOI Listing
March 2019
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In-depth characterization of the Wnt-signaling/β-catenin pathway in an in vitro model of Barrett's sequence.

BMC Gastroenterol 2019 Mar 6;19(1):38. Epub 2019 Mar 6.

Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany.

Background: An altered Wnt-signaling activation has been reported during Barrett's esophagus progression, but with rarely detected mutations in APC and β-catenin (CTNNB1) genes.

Methods: In this study, a robust in-depth expression pattern analysis of frizzled receptors, co-receptors, the Wnt-ligands Wnt3a and Wnt5a, the Wnt-signaling downstream targets Axin2, and CyclinD1, as well as the activation of the intracellular signaling kinases Akt and GSK3β was performed in an in vitro cell culture model of Barrett's esophagus. Representing the Barrett's sequence, we used normal esophageal squamous epithelium (EPC-1, EPC-2), metaplasia (CP-A) and dysplasia (CP-B) to esophageal adenocarcinoma (EAC) cell lines (OE33, OE19) and primary specimens of squamous epithelium, metaplasia and EAC. Read More

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http://dx.doi.org/10.1186/s12876-019-0957-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404335PMC
March 2019
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2.365 Impact Factor

Lysine crotonylation is involved in hepatocellular carcinoma progression.

Biomed Pharmacother 2019 Mar 9;111:976-982. Epub 2019 Jan 9.

Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, Henan, China. Electronic address:

Lysine crotonylation is a new posttranslational modification (PTM) type identified on histones, which is enriched on active gene promoters or potential enhancers in mammalian cell genomes. However, the function of lysine crotonylation in the cancer process is not known. Intriguingly, we found that lysine crotonylation expression is down-regulated in liver, stomach, kidney carcinomas, and up-regulated in thyroid, esophagus, colon, pancreas and lung carcinomas. Read More

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http://dx.doi.org/10.1016/j.biopha.2018.12.148DOI Listing
March 2019
3 Reads

Interpreting the Survival Benefit From Neoadjuvant Chemoradiotherapy Before Surgery for Locally Advanced Squamous Cell Carcinoma of the Esophagus.

J Clin Oncol 2019 Apr 6;37(12):1032-1033. Epub 2019 Mar 6.

Zachary R. McCaw, AM, and Lee-Jen Wei, PhD, Harvard TH Chan School of Public Health, Boston, MA.

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http://dx.doi.org/10.1200/JCO.18.01164DOI Listing

Combined surgery and radiotherapy as curative treatment for tracheal adenoid cystic carcinoma: a case report.

J Med Case Rep 2019 Mar 6;13(1):52. Epub 2019 Mar 6.

UOC of Oncology - ASL Latina - Distretto 1, University of Rome "Sapienza", Aprilia, LT, Italy.

Background: Adenoid cystic carcinoma of the trachea is a rare tumor, characterized by slow growth and low rate of local and distant metastasis. When achievable, complete surgical resection represents the optimal treatment approach, with the highest results in terms of overall survival. Radiation therapy is a reasonable alternative in cases of inoperable disease. Read More

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http://dx.doi.org/10.1186/s13256-019-1996-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402121PMC
March 2019
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Comparison between clinical significance of serum CXCL-8 and classical tumor markers in oesophageal cancer (OC) patients.

Clin Exp Med 2019 May 28;19(2):191-199. Epub 2019 Feb 28.

Department of Biochemical Diagnostics, Medical University of Białystok, ul. Waszyngtona 15 a, 15-269, Białystok, Poland.

C-X-C motif chemokine 8 (CXCL-8), known as interleukin-8, is a pro-inflammatory cytokine which acts as a chemotactic factor, mainly for leukocytes. CXCL-8 is produced by malignant cells, and therefore it can stimulate the growth and progression of various neoplasms, including oesophageal cancer (OC). The aim of the current study was to measure serum concentrations of chemokine CXCL-8 in OC patients and establish whether this protein might be considered a potential candidate for a tumor marker in the diagnosis and progression of OC. Read More

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http://dx.doi.org/10.1007/s10238-019-00548-9DOI Listing

Bronchoscopic cryosurgery for metastatic tumor causing central airway obstruction: A case report.

Medicine (Baltimore) 2019 Mar;98(9):e14635

School of Medicine, National Yang-Ming University, Taipei.

Rationale: Bronchoscopic cryotherapy has been considered as one of the optional interventions for unresectable malignant central airway obstruction (CAO). And it provides high safety and effectiveness in airway patency re-establishment. This report describes the interventional bronchoscopic cryotherapy for a patient with CAO caused by squamous cell carcinoma of the esophagus. Read More

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http://dx.doi.org/10.1097/MD.0000000000014635DOI Listing
March 2019
4 Reads

Fallback technique with circular stapler prevents anastomotic obstruction after esophagectomy: A case report of surgical approach.

Medicine (Baltimore) 2019 Feb;98(8):e13571

Department of Thoracic Surgery.

Rationale: While performing esophago-ileal anastomosis after esophagectomy with circular staplers, the mucosal folds of the ileum can complicate stapling and lead to obstruction, especially when the diameter of the circular stapler is equal or greater than that of the small bowel lumen.

Patient Concerns: A 53-year-old man, presented with complaints of difficulty in swallowing for 2 weeks. Fifteen years previously, he had undergone partial gastrectomy for gastric ulcers. Read More

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http://dx.doi.org/10.1097/MD.0000000000013571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408128PMC
February 2019
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