92,920 results match your criteria Esophagus Carcinoma


Changes in the Distal Esophageal Microbiota in Chinese Patients with Reflux Esophagitis.

J Dig Dis 2018 Dec 5. Epub 2018 Dec 5.

Digestive Department, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Objective: Changes in microbiota structure in the distal esophagus may be associated with the pathogenesis of gastroesophageal reflux disease. The composition of the distal esophageal microbiota between Chinese patients and healthy volunteers was compared through metagenomic high-throughput DNA sequencing and bioinformatic analyses.

Methods: Healthy volunteers (HV) and patients with reflux esophagitis (RE) were enrolled. Read More

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December 2018
1 Read

Long noncoding RNA HAND2-AS1 inhibits cancer cell proliferation, migration, and invasion in esophagus squamous cell carcinoma by regulating microRNA-21.

J Cell Biochem 2018 Dec 5. Epub 2018 Dec 5.

Department of Dermatology, Zhujiang Hospital of Southern Medical University, Guangzhou, China.

Long noncoding RNA (lncRNA) HAND2-AS1 is a well-characterized tumor suppressor in several types of malignancies, while its role in esophagus squamous cell carcinoma (ESCC) is unknown. In this study, we found that lncRNA HAND2-AS1 was downregulated, while microRNA-21 ( miRNA-21) was upregulated in tumor tissues than in adjacent healthy tissues of ESCC patients. Expression levels of lncRNA HAND2-AS1 and miRNA-21 were significantly and inversely correlated in tumor tissues but not in healthy tissues. Read More

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December 2018

Current status of esophageal endoscopy including the evaluation of smoking and alcohol consumption in Japan: an analysis based on the Japan endoscopy database.

Esophagus 2018 Dec 5. Epub 2018 Dec 5.

JED (Japan Endoscopy Database) Project Committee, Japan Gastroenterological Endoscopy Society, Tokyo, Japan.

Purpose: The aim was to investigate the current status of esophageal endoscopy, including the evaluation of smoking and alcohol consumption, in Japan.

Methods: A total of 47,441 patients who underwent 69,748 sessions of esophageal endoscopy were registered in the Japan Endoscopy Database between January 2015 and March 2017. The study variables were as follows: (1) methods for monitoring the esophagus and the time required for monitoring and (2) the status of smoking and alcohol consumption in patients with esophageal cancer and head and neck cancer. Read More

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December 2018
2 Reads

Preoperative endoscopic pyloric balloon dilatation decreases the rate of delayed gastric emptying after Ivor-Lewis esophagectomy.

Dis Esophagus 2018 Dec 1. Epub 2018 Dec 1.

Department of General-, Visceral-, and Transplant Surgery, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.

Delayed gastric emptying (DGE) after Ivor-Lewis esophagectomy occurs postoperatively in up to 50% of the patients. This pyloric dysfunction can lead to severe secondary complications postoperatively such as early aspiration, pneumonia or may even have an impact on anastomotic healing and therefore leakage. Early detection of DGE is essential to prevent further complications. Read More

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December 2018
2 Reads

Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery.

J Vis Exp 2018 Nov 14(141). Epub 2018 Nov 14.

Laboratory of Pharmaceutics, School of Pharmacy, Nihon University;

Intranasal administration has been reported to be a potential pathway for nose-to-brain delivery of therapeutic agents that circumvents the blood-brain barrier. However, there have been few reports regarding not only the quantitative analysis but also optimal administration conditions and dosing regimens for investigations of nose-to-brain delivery. The limited progress in research on nose-to-brain pathway mechanisms using rodents represents a significant impediment in terms of designing nose-to-brain delivery systems for candidate drugs. Read More

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November 2018

Reconstruction of a Posterior Tracheal Wall Defect With a Myocutaneous Pectoralis Major Flap After Salvage Cervical Exenteration for a Squamous Carcinoma of the Upper Third of the Esophagus.

Plast Surg Nurs 2018 Oct/Dec;38(4):162-165

Enrique Salmerón-González, MD, Plastic Surgeon, Plastic and Reconstructive Surgery Department, University and Polytechnic Hospital La Fe, Valencia, Spain. Elena García-Vilariño, MD, Plastic Surgeon, Plastic and Reconstructive Surgery Department, University and Polytechnic Hospital La Fe, Valencia, Spain. Pedro A. Antolin-Santamaria, MD, Plastic Surgeon, Plastic and Reconstructive Surgery Department, University and Polytechnic Hospital La Fe, Valencia, Spain. Alberto Sanchez-Garcia, MD, Plastic Surgeon, Plastic and Reconstructive Surgery Department, University and Polytechnic Hospital La Fe, Valencia, Spain. Alfonso A. Valverde-Navarro, PhD, Director, Department of Human Anatomy and Embryology, University of Valencia, Spain.

In this article, we describe the case of a 59-year-old patient suffering from a squamous cell carcinoma affecting the upper third of the esophagus, treated with a cervical exenteration with extended resection of the posterior wall of the trachea, which was reconstructed with a gastric tube transposition and a myocutaneous pectoralis major flap for coverage of the gastropharyngeal anastomosis and stabilization of the posterior tracheal wall. Also, a review of literature regarding posterior tracheal wall reconstruction is performed. Read More

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December 2018
2 Reads

A Lodged Barramundi Fish-Bone Stabbing the Piriform Fossa in a Child.

Pediatr Emerg Care 2018 Dec;34(12):e243-e245

Pediatric Otolaryngology-Head & Neck Surgery, BC Children's Hospital, Vancouver, British Columbia, Canada.

Unintentional ingestion of a fish bone is common in children, especially among families with high consumption of seafood. Complications in children are extremely rare. We describe a 3-year-old healthy boy who had a large bone of Barramundi fish lodged in his upper esophagus causing significant distress. Read More

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December 2018

Lifestyle Modifications in Adults and Older Adults With Chronic Gastroesophageal Reflux Disease (GERD).

Crit Care Nurs Q 2019 Jan/Mar;42(1):64-74

NYU Langone Health, Tisch Hospital, New York (Mr Commisso) and NYU Rory Meyers College of Nursing, New York (Mr Lim).

Gastroesophageal reflux disease (GERD) is a chronic disorder that causes the unwanted backflow of gastric contents into the esophagus, throat, and mouth. Gastroesophageal reflux disease affects roughly 20% of the US population. It is estimated that older adults experience GERD symptoms more commonly and with greater severity because of age-related physiologic changes. Read More

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December 2018
1 Read

A Simple Technique for Three-Dimensional Imaging and Segmentation of Brain Vasculature U sing Fast Free-of-Acrylamide Clearing Tissue in Murine.

Cell J 2019 Apr 18;21(1):49-56. Epub 2018 Nov 18.

The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran. Electronic

Objective: Fast Free-of-Acrylamide Clearing Tissue (FACT) is a recently developed protocol for the whole tissue three-dimensional (3D) imaging. The FACT protocol clears lipids using sodium dodecyl sulfate (SDS) to increase the penetration of light and reflection of fluorescent signals from the depth of cleared tissue. The aim of the present study was using FACT protocol in combination with imaging of auto-fluorescency of red blood cells in vessels to image the vasculature of a translucent mouse tissues. Read More

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Radio-morphology: Parametric Shape-Based Features in Radiotherapy.

Med Phys 2018 Dec 3. Epub 2018 Dec 3.

Department of Radiation Oncology and Molecular Radiation Sciences, Johns, Hopkins University, Baltimore, MD, 21287, USA.

Purpose: In radiotherapy, it is necessary to characterize dose over the patient anatomy to target areas and organs at risk. Current tools provide methods to describe dose in terms of percentage of volume and magnitude of dose, but are limited by assumptions of anatomical homogeneity within a region of interest (ROI) and provide a non-spatially aware description of dose. A practice termed radio-morphology is proposed as a method to apply anatomical knowledge to parametrically derive new shapes and substructures from a normalized set of anatomy, ensuring consistently identifiable spatially-aware features of the dose across a patient set. Read More

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December 2018

Endoscopic therapy for confirmed low-grade dysplasia in Barrett's esophagus.

Transl Gastroenterol Hepatol 2018 29;3:83. Epub 2018 Oct 29.

Unità Operativa Complessa di Endoscopia Digestiva Chirurgica, Dipartimento Scienze Gastroenterologiche, Endocrino-Metaboliche e Nefro-Urologiche Istituto di Clinica Chirurgica Generale e Terapia Chirurgica Fondazione Policlinico Universitario A. Gemelli, Università Cattolica del Sacro Cuore, Roma, Italia.

Barrett's esophagus (BE) is a premalignant condition characterized by replacement of the esophageal lining with metastatic columnar epithelium. To date, the management in case of confirmed low-grade dysplasia (LGD) remains controversial. In this article we summarize the available endoscopic options and their results in terms of efficacy and safety in the treatment of confirmed LGD in BE. Read More

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October 2018
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Qualitative and Quantitative DNA- and RNA-Based Analysis of the Bacterial Stomach Microbiota in Humans, Mice, and Gerbils.

mSystems 2018 Nov-Dec;3(6). Epub 2018 Nov 20.

Universität Hohenheim, Stuttgart, Germany.

Clinical interventions in the stomach have been linked to fecal microbiota alterations, suggesting a function of the stomach in gastrointestinal (GI) homeostasis. We sought to determine the taxonomic bacterial biogeography of the upper GI tract, including different sites within the human stomach (cardia, corpus, and antrum), adjacent upstream (esophagus) and downstream (duodenum) locations, and luminal contents (aspirate), as well as whole-stomach samples from mice and gerbils. Qualitative and quantitative DNA- and RNA-based taxonomic microbiota analyses were combined to study the relationship of relative and absolute bacterial abundances and transcriptionally active bacterial microbiota components in the stomach of humans and mice. Read More

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November 2018

Salvage nitrous oxide cryotherapy of refractory colon neoplasia embedded within an endoclip.

Endosc Int Open 2018 Dec 29;6(12):E1410-E1412. Epub 2018 Nov 29.

Zucker School of Medicine at Hofstra/Northwell, Northwell Health System, Division of Gastroenterology, Long Island Jewish Medical Center, New Hyde Park, New York, United States.

 This is a case report on use of the CryoBalloon as a salvage technique for ablation of residual neoplasia at an endoscopic mucosal resection site. The site contained an embedded clip that could not be removed at two different sessions by three experienced endoscopists. On follow-up endoscopy, the clips and residual polyp no longer remained. Read More

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December 2018

Preliminary study on application of augmented reality visualization in robotic thyroid surgery.

Ann Surg Treat Res 2018 Dec 26;95(6):297-302. Epub 2018 Nov 26.

Department of Biomedical Engineering, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

Purpose: Increased robotic surgery is attended by increased reports of complications, largely due to limited operative view and lack of tactile sense. These kinds of obstacles, which seldom occur in open surgery, are challenging for beginner surgeons. To enhance robotic surgery safety, we created an augmented reality (AR) model of the organs around the thyroid glands, and tested the AR model applicability in robotic thyroidectomy. Read More

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December 2018
1 Read

Proton beam therapy for gastrointestinal cancers: past, present, and future.

J Gastrointest Oncol 2018 Oct;9(5):962-971

Department of Radiation Oncology, Miami Cancer Institute, Baptist Health South Florida, Miami, FL, USA.

Despite the conformality of modern X-ray therapy limiting high dose received by normal tissues the physical properties of X-rays make it impossible to avoid dose being delivered distal to the target. This "exit dose" is likely clinically significant especially for patients with gastrointestinal (GI) cancers when considering that even low dose received by the heart, lungs, bowel, and other radiosensitive structures can lead to morbidity and even may affect long-term tumor control. In contrast, proton beam therapy (PBT) delivers no "exit dose" and a growing body of literature suggests that this may improve clinical outcomes by reducing toxicity and even allowing for safe dose intensification to enhance tumor control. Read More

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October 2018

Anaemia and its effects on tumour regression grade and survival following chemotherapy in adenocarcinoma of the oesophagus.

J Gastrointest Oncol 2018 Oct;9(5):797-805

Department of Biomedical Research, University of Nottingham, Nottingham, UK.

Background: Anaemia reduces the efficacy of chemotherapy in gastric cancer. However, it has not been studied in oesophageal cancer. We investigated whether anaemia impacts on survival and the efficacy of chemotherapy, in adenocarcinoma of the oesophagus for those undergoing neoadjuvant chemotherapy and then surgical resection. Read More

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October 2018

First case on fluorodeoxyglucose positron emission tomography/computerized tomography of a distant skip metastases to parotid node from esophageal adenocarcinoma.

World J Nucl Med 2018 Oct-Dec;17(4):302-304

Department of Nuclear Medicine, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom.

We are presenting the first case of a gastro-oesophageal junction adenocarcinoma with metastasis only to the intraparotid lymph node simulating Warthin's tumor. A 66-year-old man underwent an esophagogastroduodenoscopy that found circumferential ulcerated esophageal tumor beginning 40 cm from incisors resulting in stricture and two discrete erosions in the proximal third of esophagus. Biopsies from the stricture have demonstrated a poorly differentiated gastric adenocarcinoma. Read More

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December 2018

F-fluorodeoxyglucose positron emission tomography/computed tomography in carcinoma of unknown primary: A subgroup-specific analysis based on clinical presentation.

World J Nucl Med 2018 Oct-Dec;17(4):219-222

Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Centre Annexe, Parel, Maharashtra, India.

The aim of this study was to explore the clinical efficacy of F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) in tumor detection in patients with proven or suspected carcinoma of unknown primary origin (CUP) and making a subgroup-specific analysis. This was a retrospective, cross-sectional survey of patients with CUP syndrome who were referred for F-FDG PET-CT studies over a 2-year period. FDG-PET-CT scans were performed in compliance with the standard whole-body protocol, i. Read More

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December 2018

Using a Sternocleidomastoid Muscle Flap to Close an Iatrogenic Tracheoesophageal Fistula in a Patient With Advanced Laryngeal Cancer: A Case Report and Literature Review.

Ann Plast Surg 2018 Dec 3. Epub 2018 Dec 3.

From the Department of Plastic Surgery, Mackay Memorial Hospital, Taipei, Taiwan.

Background: An iatrogenic tracheoesophageal (TE) fistula is one possible complication after total laryngectomy with flap reconstruction. We used sternocleidomastoid (SCM) rotation flap to close a TE fistula.

Methods And Results: A 69-year-old man with laryngeal cancer underwent total laryngectomy with radial forearm free flap reconstruction. Read More

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December 2018

Intestinal metaplasia at the gastroesophageal junction is associated with gastroesophageal reflux but not with Helicobacter pylori infection.

Scand J Gastroenterol 2018 Dec 5:1-7. Epub 2018 Dec 5.

a Department of Gastroenterology, Skåne University Hospital , Clinical Sciences Lund, Lund University , Lund , Sweden.

Objective: Studies of the etiology of intestinal metaplasia (IM) at a normal appearing gastroesophageal junction (GEJ) are conflicting as associations with both H. Pylori (HP) infection and gastroesophageal reflux has been reported. The aim of this study was to investigate whether IM at the GEJ is associated with gastroesophageal reflux or HP infection. Read More

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December 2018

Snare combined with endoclips in endoscopic submucosal dissection with mucosal traction for gastroesophageal neoplasia.

J Gastroenterol Hepatol 2018 Dec 4. Epub 2018 Dec 4.

Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, 510515, China.

Background And Aims: Mucosal traction as a "second hand" in endoscopic submucosal dissection (ESD) is very helpful for ESD operators. The efficacy of using a snare combined with endoclips to assist in ESD (SC-ESD) was evaluated whether it could achieve peroral external traction (PET) and internal traction (PIT) and real-time adjustment of mucosal traction position. This study aimed to preliminarily evaluate its feasibility. Read More

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December 2018

Pinpricks: Needling, numbness, and temporalities of pain.

Authors:
Lan A Li

Prog Brain Res 2018 28;243:205-229. Epub 2018 Nov 28.

Presidential Scholars in Society and Neuroscience, Center for Science and Society, Columbia University, New York, NY, United States. Electronic address:

Acupuncture analgesia appeared relatively straightforward. A patient laid awake as the practitioner needled selected sites on the body to induce numbness for surgery. Numerous reports emerging from China in the 1970s featured men and women resting on operating tables, smiling into the camera, surrounded by doctors who attended to the excised region-the esophagus, brain, gut, heart, or lungs. Read More

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November 2018

Facteurs en cause et formes cliniques du reflux gastro-oesophagien chez l’adulte. Une prévalence élevée qui augmente avec l’âge.

Rev Prat 2016 Dec;66(10):1080-1083

Explorations fonctionnelles digestives, hôpital Pontchaillou, Rennes, France.

Factors and clinical forms of gastroesophageal reflux disease in adults. Gastro-oesophageal reflux (GERD) is a common complaint. Factors involved in GERD are the antireflux barrier dysfunction, the oesophageal sensitivity disorders, impaired oesophageal clearance, the acid component of the refluxate, and impaired gastric emptying. Read More

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December 2016

Quantification of Mg2+, Ca2+ and H+ transport by the gastrointestinal tract of the goldfish, Carassius auratus, using the Scanning Ion-selective Electrode Technique (SIET).

PLoS One 2018 4;13(12):e0207782. Epub 2018 Dec 4.

Department of Biology, York University, Toronto, Ontario, CA.

An in vitro gut-sac technique and the scanning ion-selective electrode technique (SIET) were used to characterize Mg2+, Ca2+, and H+ transport at both the mucosal and serosal surfaces of non-everted and everted gastrointestinal tissues obtained from Carassius auratus. As part of the study, two magnesium ionophores were compared (II vs. VI). Read More

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December 2018
2 Reads

Calcium Receptor and Nitric Oxide Synthase Expression in Circular Muscle of Lower Esophagus from Patients with Achalasia.

Chin Med J (Engl) 2018 Dec;131(23):2882-2885

Research Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, China.

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December 2018

Benefits of the Seattle biopsy protocol in the diagnosis of Barrett's esophagus in a Chinese population.

World J Clin Cases 2018 Nov;6(14):753-758

Division of Gastroenterology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan.

Aim: To investigate the benefits of the Seattle protocol in the diagnosis of Chinese individuals with Barrett's esophagus.

Methods: Subjects enrolled were patients from one center with endoscopically-suspected esophageal metaplasia. These patients first received narrow-band imaging-targeted biopsy, and later, the Seattle protocol-guided biopsy, within a period from October 2012 to December 2014. Read More

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November 2018

Endoscopic repair of spontaneous esophageal rupture during gastroscopy: A CARE compliant case report.

Medicine (Baltimore) 2018 Nov;97(48):e13422

Department of Gastroenterology, The Fifth Affiliated Hospital of Wenzhou Medical University.

Rationale: Most of esophageal rupture is a very serious life-threatening benign gastrointestinal tract disease with high mortality. However, there are a few cases of spontaneous esophageal rupture during gastroscopy.

Patient Concerns: A 57-year-old man who underwent a routine diagnostic gastroscopy due to food obstruction was reported. Read More

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November 2018

Successful treatment of drug-induced esophageal ulcer in a patient with chronic heart failure: A case report.

Medicine (Baltimore) 2018 Nov;97(48):e13380

Department of Gastroenterology and Hepatology.

Rationale: Although esophageal compression due to cardiomegaly may be a risk factor of drug-induced esophageal injuries (DIEIs), the causal relationship between the two conditions has not been fully demonstrated.

Patient Concerns: We present a case of a drug-induced esophageal ulcer caused by left atrial enlargement in a 44-year-old woman with end-stage hypertrophic cardiomyopathy. Upper gastrointestinal endoscopy showed a deep, circumferential ulcer in the middle thoracic esophagus. Read More

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November 2018
2 Reads

Focally amplified lncRNA on chromosome 1 regulates apoptosis of esophageal cancer cells via DRP1 and mitochondrial dynamics.

IUBMB Life 2018 Nov 30. Epub 2018 Nov 30.

Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530007, China.

Long noncoding RNAs (lncRNAs), a family of noncoding RNA transcripts with a length of <200 nucleotides (nts), have been associated with the pathological development of various types of carcinogenesis. Focally amplified lncRNA on chromosome 1 (FAL1) is a recently identified lncRNA. In the current study, we aimed to investigate the physiological function of FAL1 in esophageal squamous cell carcinoma (ESCC). Read More

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November 2018
1 Read

Long-term Results of Robotic Modified Belsey (Gastroesophageal Valvuloplasty) Fundoplication.

Surg Technol Int 2018 Nov 30;34. Epub 2018 Nov 30.

University of Arizona Medical Center, Tucson, AZ.

Purpose: Nissen fundoplication is associated with poor long-term durability, as well as dysphasia and gas bloat. We report here the long-term results of modified Belsey fundoplication (Gastroesophageal Valvuloplasty; GEV) performed laparoscopically using a surgical robot.

Methods: Patients who underwent robotic GEV were reviewed retrospectively. Read More

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November 2018
6 Reads

Omentopexy in Sleeve Gastrectomy Reduces Early Gastroesophageal Reflux Symptoms.

Surg Laparosc Endosc Percutan Tech 2018 Nov 28. Epub 2018 Nov 28.

Federal University of Pernambuco, Recife.

Introduction: Laparoscopic sleeve gastrectomy (LSG) is one of the surgical procedures indicated in the treatment of obesity. The occurrence of gastroesophageal reflux (GER) in the postoperative period of this surgery is related to a reduction in the lower esophageal sphincter (LES) tone and the presence of gastric residual fundus (RF) associated with increased gastric intraluminal pressure. Fixation of the remaining gastric reservoir to the gastrosplenic and gastrocolic ligaments (omentopexy) has emerged as a technical option to avoid or decrease GER in the postoperative period of LSG. Read More

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November 2018
2 Reads

Case of Disease in the Larynx Mistaken for Stricture of the Œsophagus.

Authors:
John Shaw

Lond Med Phys J 1822 Sep;48(283):185-190

Lecturer on Anatomy and Surgery.

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September 1822

Case of Contracted Œsophagus.

Authors:
Smith

Med Phys J 1803 Jun;9(52):552-554

Limehouse.

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Tumor Control and Toxicity Following SBRT for Ultracentral, Central and Paramediastinal Lung Tumors.

Pract Radiat Oncol 2018 Nov 26. Epub 2018 Nov 26.

Department of Radiation Oncology, University of California Davis Comprehensive Cancer Center. Electronic address:

Purpose: Increased rates of toxicity have been described following stereotactic body radiotherapy (SBRT) for central lung tumors within 2 cm of the proximal bronchial tree (PBT). Recent studies have defined a new class of "ultracentral" tumors. We report our experience treating ultracentral, central, and paramediastinal tumors with SBRT and compare toxicity, disease control, and survival. Read More

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November 2018
2 Reads

Hot beverages and oesophageal cancer risk in western Kenya: findings from the ESCCAPE case-control study.

Int J Cancer 2018 Nov 29. Epub 2018 Nov 29.

Section of Environment and Radiation, International Agency for Research on Cancer (IARC), Lyon, France.

Oesophageal squamous cell carcinoma (ESCC) has markedly high incidence rates in Kenya and much of East Africa, with a dire prognosis and poorly understood aetiology. Consumption of hot beverages - a probable carcinogen to humans - is associated with increased ESCC risk in other settings and is habitually practiced in Kenya. We conducted a case-control study in Eldoret, western Kenya between August 2013 and March 2018. Read More

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November 2018
1 Read

Associated risks of proton pump inhibitors and their influence on prescribing habits: is change truly warranted?

Authors:
A Dua M Venu

Dis Esophagus 2018 Nov 28. Epub 2018 Nov 28.

Loyola University Medical Center, Division of Gastroenterology , Stritch School of Medicine, Maywood, Illinois, USA.

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November 2018

A biomarker panel predicts progression of Barrett's esophagus to esophageal adenocarcinoma.

Dis Esophagus 2018 Nov 28. Epub 2018 Nov 28.

Medical Research Council Cancer Unit, Hutchison-MRC Research Center, University of Cambridge,Cambridge,United Kingdom.

Progression from Barrett's esophagus (BE) to esophageal adenocarcinoma (EAC) is uncommon but the consequences are serious. Predictors of progression are essential to optimize resource utilization. This study assessed the utility of a promising panel of biomarkers applicable to routine paraffin embedded biopsies (FFPE) to predict progression of BE to EAC in a large population-based, nested case-control study. Read More

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November 2018
2 Reads

Enhanced recovery protocol in esophagectomy, is it really worth it? A cost analysis related to team experience and protocol compliance.

Dis Esophagus 2018 Nov 28. Epub 2018 Nov 28.

Division of General and Upper Gastrointestinal Surgery, Department of Surgery.

Application of enhanced recovery protocols (ERP) in esophageal surgery seems to lead an advantage in terms of length of hospital staying and outcomes, but only few data exist on its cost effectiveness. Previous literature analyzed pre- and post-ERP groups, finding a cost reduction with the introduction of the pathway. We aimed to study the influence on costs of accumulating experience and compliance in an ERP group. Read More

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November 2018

Outcomes of nutritional jejunostomy in the curative treatment of esophageal cancer.

Dis Esophagus 2018 Nov 28. Epub 2018 Nov 28.

Surgical Care Science, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Substantial weight loss and eating problems are common before and after esophagectomy for cancer. The use of jejunostomy might prevent postoperative weight loss, but studies evaluating other outcomes are scarce. This study aims to assess the influence of jejunostomy on postoperative health-related quality of life (HRQOL), complications, reoperation, hospital stay, and survival. Read More

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November 2018
5 Reads

Preoperative sarcopenia is a predictor of poor prognosis of esophageal cancer after esophagectomy: a comprehensive systematic review and meta-analysis.

Dis Esophagus 2018 Nov 28. Epub 2018 Nov 28.

Department of Thoracic Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China.

The impact of preoperative sarcopenia on long-term survival of esophageal cancer patients after esophagectomy remains unclear. We conducted an updated meta-analysis focusing on current topic comprehensively. We systematically searched relevant studies investigating the impact of preoperative sarcopenia on survival of patients with surgically treated esophageal cancer in PubMed, Embase, and Web of Science up to July 20, 2018. Read More

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November 2018

Does the Pittsburgh Severity Score predict outcome in esophageal perforation?

Dis Esophagus 2018 Nov 28. Epub 2018 Nov 28.

Department of Upper Gastrointestinal Surgery, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.

Esophageal perforation is an uncommon and challenging surgical emergency associated with high rates of morbidity and mortality. At present, no consensus exists on optimal management of the condition. The Pittsburgh Severity Score (PSS) is a tool intended to stratify perforation severity and guide treatment. Read More

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November 2018

Does robot-assisted minimally invasive esophagectomy really have the advantage of lymphadenectomy over video-assisted minimally invasive esophagectomy in treating esophageal squamous cell carcinoma? A propensity score-matched analysis based on short-term outcomes.

Dis Esophagus 2018 Nov 28. Epub 2018 Nov 28.

Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, China.

This study aims to investigate advantages of robot-assisted minimally invasive esophagectomy (RAMIE) over video-assisted minimally invasive esophagectomy (VAMIE) in treating esophageal squamous cell carcinoma by applying propensity score-matched analysis. From April 2016 to January 2018, consecutive patients undergoing a McKeown RAMIE or VAMIE for esophageal squamous cell carcinoma were prospectively included for analysis. Baseline data, pathological findings, and short-term outcomes of the two groups (RAMIE group and VAMIE group) were collected and compared. Read More

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November 2018
2 Reads

Impact of perineural invasion as a histopathological prognostic factor in ypStage II/III oesophageal squamous cell carcinoma.

Eur J Cardiothorac Surg 2018 Nov 27. Epub 2018 Nov 27.

School of Medicine, National Yang-Ming University, Taipei, Taiwan.

Objectives: The 8th edition American Joint Committee on Cancer Tumour-Nodes-Metastasis (TNM) staging system distinguishes between the clinical (c), pathological (p) and post-neoadjuvant pathological (yp) stage groups. However, the ability to discriminate between ypStage II and ypStage III is poor. We aim to identify prognostic factors in patients with ypStage II/III oesophageal squamous cell carcinoma. Read More

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November 2018