20,360 results match your criteria Esophagitis

Peroral endoscopic myotomy: 10-year outcomes from a large, single-center U.S. series with high follow-up completion and comprehensive analysis of long-term efficacy, safety, objective GERD, and endoscopic functional luminal assessment.

Gastrointest Endosc 2021 May 11. Epub 2021 May 11.

Division of Gastroenterology, Hepatology & Nutrition, NYU-Winthrop Hospital, Mineola, NY, USA.

Background And Aims: Peroral endoscopic myotomy (POEM) is becoming the treatment of choice for achalasia. Data beyond 3 years are emerging but limited. We herein report our 10-year experience, focusing on long-term efficacy and safety including the prevalence, management, and sequelae of postoperative reflux. Read More

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Genotyping, antifungal susceptibility, enzymatic activity, and phenotypic variation in Candida albicans from esophageal candidiasis.

J Clin Lab Anal 2021 May 14:e23826. Epub 2021 May 14.

Department of Medical Mycology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background: Esophageal candidiasis is the most frequent form of esophagitis. The pathogenicity of Candida spp. is related to a combination of microbial factors, hydrolytic enzyme secretion and phenotypic switching. Read More

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Empiric proton pump inhibitor therapy after esophageal food impaction may mask eosinophilic esophagitis diagnosis at follow-up.

Dis Esophagus 2021 May 13. Epub 2021 May 13.

Division of Gastroenterology and Hepatology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

Esophageal food impaction (EFI) is often the first presentation for patients with eosinophilic esophagitis (EoE); however, there is significant heterogeneity in the management of EFI. We aimed to study the impact of EFI management, particularly post-EFI medication prescriptions on EoE diagnosis, follow-up, and recurrence in patients with endoscopic features of EoE. In our retrospective study, adults presenting between 2007 and 2017 with EFI requiring endoscopic dis-impaction with endoscopic features of EoE (furrows, rings, and/or exudates) were included. Read More

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Utility of Routine Esophageal Biopsies in Patients With Refractory Reflux Symptoms.

Am J Gastroenterol 2021 Apr;116(4):816-820

1Department of Gastroenterology & Hepatology, Amsterdam Gastroenterology and Metabolism, University Medical Centers Amsterdam, Amsterdam, the Netherlands; 2Department of Gastroenterology and Hepatology, Catharina Hospital Eindhoven, Eindhoven, the Netherlands.

Introduction: This study aimed to assess the diagnostic yield of routine esophageal biopsies in patients with refractory reflux symptoms.

Methods: We prospectively enrolled consecutive patients referred for upper endoscopy and collected histological, clinical, and endoscopic data.

Results: Of the 301 included patients, 14 (4. Read More

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A phase I study of high dose camostat mesylate in healthy adults provides a rationale to repurpose the TMPRSS2 inhibitor for the treatment of COVID-19.

Clin Transl Sci 2021 May 13. Epub 2021 May 13.

Department of Clinical Pharmacology and Therapeutics, Faculty of Medicine, Oita University, Oita, Japan.

Camostat mesylate, an oral serine protease inhibitor, is used to treat chronic pancreatitis and reflux esophagitis. Recently, camostat mesylate and its active metabolite 4-(4-guanidinobenzoyloxy)phenylacetic acid (GBPA) were reported to inhibit the infection of cells by severe acute respiratory syndrome coronavirus 2 by inhibiting type II transmembrane serine protease. We conducted a phase I study to investigate high-dose camostat mesylate as a treatment for coronavirus disease 2019. Read More

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Serum metabolomics analysis for the progression of esophageal squamous cell carcinoma.

J Cancer 2021 2;12(11):3190-3197. Epub 2021 Apr 2.

Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.

Previous metabolomics studies have found differences in metabolic characteristics between the healthy and ESCC patients. However, few of these studies concerned the whole process of the progression of ESCC. This study aims to explore serum metabolites associated with the progression of ESCC. Read More

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Drivers of Variation in Diagnosis and Management of Eosinophilic Esophagitis: A Survey of Pediatric Gastroenterologists.

Dig Dis Sci 2021 May 11. Epub 2021 May 11.

Department of Pediatrics, University of Washington/Seattle Children's Hospital, 4800 Sand Point Way NE, OB.9.620.1-Gastroenterology and Hepatology, Seattle, WA, 98105, USA.

Background: Widespread variation in the diagnosis and treatment of eosinophilic esophagitis (EoE) has previously been reported among adult gastroenterologists; however, variation in EoE practice in among pediatric populations is poorly characterized. The study objectives were to describe guideline adherence and understand reasons for variation in EoE practice among pediatric gastroenterologists following publication of the updated 2018 international EoE guidelines.

Methods: We developed and administered a 28-item survey to pediatric gastroenterologists via an email listserv using the PEDGI Bulletin Board from 03/2019 to 04/2019. Read More

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Association Between Gastroesophageal Flap Valve and Endoscopically Diagnosed Gastroesophageal Reflux Disease According to Lyon Consensus: A Meta-analysis of Asian Studies.

J Clin Gastroenterol 2021 May 11. Epub 2021 May 11.

Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing Department of Gastroenterology and Hepatology, Pinghu Hospital, Health Science Center, Shenzhen University, Shenzhen, People's Republic of China.

Background: Lyon Consensus altered the previous understanding of endoscopic gastroesophageal reflux disease (GERD) and pointed out that only high-grade reflux esophagitis (RE) [Los Angeles (LA) grades C or D], Barrett's esophagus or peptic stricturing were considered confirmatory evidence for GERD but low-grade RE (LA grades A or B) was regarded as suspected GERD. We aimed to summarize the possible relationship between gastroesophageal flap valve (GEFV) and endoscopic GERD according to Lyon Consensus using meta-analysis of studies done in Asia.

Materials And Methods: Comprehensive searches of PubMed, WOS, Embase, SinoMed, and CNKI databases were completed to identify eligible studies published before September 22, 2019. Read More

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Bidirectional crosstalk between eosinophils and esophageal epithelial cells regulates inflammatory and remodeling processes.

Mucosal Immunol 2021 May 10. Epub 2021 May 10.

Division of Allergy & Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

Eosinophils accumulate adjacent to epithelial cells in the mucosa of patients with eosinophilic esophagitis (EoE), yet the bidirectional communication between these cells is not well understood. Herein, we investigated the crosstalk between human eosinophils and esophageal epithelial cells. We report that blood-derived eosinophils have prolonged survival when cocultured with epithelial cells; 96 ± 1% and 30 ± 6% viability was observed after 7 and 14 days of coculture, respectively, compared with 1 ± 0% and 0 ± 0% of monoculture. Read More

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One march, many paths: Insights into allergic march trajectories.

Ann Allergy Asthma Immunol 2021 May 7. Epub 2021 May 7.

Division of Allergy and Immunology and Center for Pediatric Eosinophilic Disorders, Children's Hospital of Philadelphia; Institute for Immunology and Department of Pediatrics, Perelman School of Medicine, Philadelphia, PA, 19104, USA. Electronic address:

Objective: The classical allergic march model posits that atopy begins in infancy with atopic dermatitis and progresses to asthma and allergic rhinitis in a subset of individuals. The growing prevalence and severity of allergic diseases has prompted renewed interest in refining this model. This review outlines epidemiologic evidence for the existence of allergic march trajectories (distinct paths of atopy development in individuals), reviews the roles that genetics, environment, and disease endotypes play in determining trajectory outcomes, and discusses the clinical utility of the trajectory model. Read More

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Risk factors, endoscopic findings, and treatments in upper gastrointestinal bezoars: multi-center experience in Iran.

Gastroenterol Hepatol Bed Bench 2021 ;14(2):160-164

Golestan Research Center of Gastroenterology and Hepatology (GRCGH), Golestan University of Medical Sciences, Gorgan, Iran.

Aim: The current study aimed to investigate the risk factors, endoscopic findings, and treatments of upper gastrointestinal bezoars.

Background: Bezoars are compact masses formed by the accumulation of dietary fiber, undigested food, hair, or medications. The majority of bezoars are asymptomatic, but they may cause serious symptoms or even life-threatening events such as bleeding, obstruction, or perforation. Read More

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January 2021

The use of biologics in food allergy.

Clin Exp Allergy 2021 May 9. Epub 2021 May 9.

Johns Hopkins University School of Medicine, Baltimore, MD, U.S.A.

Background: Food allergy continues to pose problems due to its increased frequency and its increasingly high severity. In this context, alongside the traditional avoidance strategies of allergenic foods and desensitization through the cautious progression of exposure to foods in the context of oral immunotherapy (OIT), alternative strategies have made their way in the last decades. We review the possibilities of intervention in food allergy with the use of biological drugs capable of interfering with the synthesis of IgE, with their mechanisms of action, or with the complex of biological mechanisms that lead to the establishment of a food allergy. Read More

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Variants and Pitfalls in PET/CT Imaging of Gastrointestinal Cancers.

Semin Nucl Med 2021 May 5. Epub 2021 May 5.

Molecular Imaging and Therapy Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY. Electronic address:

In the past two decades, PET/CT has become an essential modality in oncology increasingly used in the management of gastrointestinal (GI) cancers. Most PET/CT tracers used in clinical practice show some degree of GI uptake. This uptake is quite variable and knowledge of common patterns of biodistribution of various radiotracers is helpful in clinical practice. Read More

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Roles of innate lymphoid cells (ILCs) in allergic diseases: The 10-year anniversary for ILC2s.

J Allergy Clin Immunol 2021 May;147(5):1531-1547

Department of Immunology, Mayo Clinic, Rochester, Minn; Division of Allergy, Asthma, and Immunology and Department of Medicine, Mayo Clinic, Scottsdale, Ariz. Electronic address:

In the 12 years since the discovery of innate lymphoid cells (ILCs), our knowledge of their immunobiology has expanded rapidly. Group 2 ILCs (ILC2s) respond rapidly to allergen exposure and environmental insults in mucosal organs, producing type 2 cytokines. Early studies showed that epithelium-derived cytokines activate ILC2s, resulting in eosinophilia, mucus hypersecretion, and remodeling of mucosal tissues. Read More

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Intra- and interobserver agreement of histopathological findings in pediatric patients with eosinophilic esophagitis.

J Pediatr (Rio J) 2021 May 5. Epub 2021 May 5.

Universidade Federal do Paraná, Departamento de Pediatria, Curitiba, PR, Brazil.

Objective: To assess intra- and interobserver agreement among non-expert pathologists in identifying features of the eosinophilic esophagitis histologic scoring system (EoEHSS) in pediatric patients.

Patients And Methods: The authors used 50 slides from patients (aged 1-15 years; 72% male) with EoE. EoEHSS evaluates eosinophilic inflammation and other features including epithelial basal zone hyperplasia, eosinophilic abscesses, eosinophil surface layering, dilated intercellular spaces, surface epithelial alteration, dyskeratotic epithelial cells, and lamina propria fibrosis. Read More

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Suspected acquired narcolepsy in 8 dogs.

J Vet Intern Med 2021 May 7. Epub 2021 May 7.

Evidensia Small Animal Hospital 'Hart van Brabant', Waalwijk, The Netherlands.

Background: Acquired narcolepsy has rarely been reported in veterinary medicine.

Objective: To describe the presentation, clinicopathological features, diagnostic imaging findings, and management of dogs with suspected-acquired narcolepsy.

Animals: Eight dogs with clinical features consistent with acquired narcolepsy. Read More

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Candida Esophagitis Associated With Adalimumab for Hidradenitis Suppurativa.

Cutis 2021 Mar;107(3):E6-E7

Drs. Nazarian and Smith are from the Icahn School of Medicine at Mount Sinai, New York, New York. Dr. Smith is from the Department of Dermatology. Dr. Farberg is from the Section of Dermatology, Baylor University Medical Center, Dallas, Texas.

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Clozapine- and Olanzapine-induced oesophagitis and haematemesis: A case report.

Aust N Z J Psychiatry 2021 May 5:48674211010333. Epub 2021 May 5.

NWAMHS, Broadmeadows Inpatient Unit, Broadmeadows, VIC, Australia.

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Concurrent chemoradiotherapy versus radiotherapy alone for patients with locally advanced esophageal squamous cell carcinoma in the era of intensity modulated radiotherapy: a propensity score-matched analysis.

Thorac Cancer 2021 May 5. Epub 2021 May 5.

Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: To investigate the survival benefit of concurrent chemoradiotherapy (CCRT) for patients with locally advanced esophageal squamous cell carcinoma (ESCC) during the years of intensity-modulated radiotherapy (IMRT).

Methods: Medical records of 1089 patients with ESCC who received IMRT from January 2005 to December 2017 were retrospectively reviewed. A total of 617 patients received CCRT, 472 patients received radiotherapy (RT) alone. Read More

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Adulthood of patients after oesophageal atresia repair- General Surgeon's Guide.

Pol Przegl Chir 2021 Mar;93(3):1-5

Jagiellonian University Medical College, Department of Pediatric Surgery, University Children's Hospital, Kraków, Poland.

Introduction Despite proper surgical management in neonatal period, congenital oesophageal atresia [OA] may present serious source of lifelong disorders. The objective of our study is to present the most important facts about oesophageal atresia, types of treatment and possible complications which might demand surgical management in adult life. We would like to familiarize general surgeons with this matter to provide OA patients with proper medical care. Read More

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Ocrelizumab-induced inflammatory bowel disease-like illness characterized by esophagitis and colitis.

Ann Gastroenterol 2021 27;34(3):447-448. Epub 2021 Jan 27.

Department of Gastroenterology (Alex Barnes, Dirk Hofmann, Réme Mountifield).

Ocrelizumab is an intravenous anti-CD20 monoclonal antibody, approved for use in primary progressive multiple sclerosis due to its selective depletion of B-lymphocytes. Herein we describe the case of a 56-year-old female who developed odynophagia and bloody diarrhea following treatment with ocrelizumab. This was characterized endoscopically by ulcerations in the esophagus and colon. Read More

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January 2021

Blood mRNA levels of T cells and IgE receptors are novel non-invasive biomarkers for eosinophilic esophagitis (EoE).

Clin Immunol 2021 May 1;227:108752. Epub 2021 May 1.

John W. Deming Department of Medicine, Section of Pulmonary Diseases, Tulane Eosinophilic Disorder Center (TEDC), Tulane University School of Medicine, New Orleans, LA, USA. Electronic address:

Eosinophilic esophagitis (EoE) is often misdiagnosed as GERD; therefore, the goal of the current study is to establish a non-invasive diagnostic and monitoring biomarker that differentiated GERD from EoE. Reports indicates that IL-15 responsive iNKT cells and tissue specific IgE have a critical in EoE pathogenesis, not in GERD. Therefore, we tested the hypothesis that the panel of IL-15-responsive T cell and IgE receptors may be novel non-invasive biomarkers for EoE. Read More

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Circumferential esophageal hiatal rim reconstruction for treatment of persistent regurgitation in brachycephalic dogs: 29 cases (2016-2019).

J Am Vet Med Assoc 2021 May;258(10):1091-1097

Objective: To describe a technique for circumferential esophageal hiatal rim reconstruction and to report outcomes in brachycephalic dogs with persistent regurgitation treated with the technique.

Animals: 29 client-owned brachycephalic dogs.

Procedures: Dogs that had undergone circumferential esophageal hiatal rim reconstruction between January 1, 2016, and December 31, 2019, for treatment of persistent regurgitation were identified through a search of the medical record database of The Animal Hospital at Murdoch University. Read More

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Gene expression profiling of inflammatory cytokines in esophageal biopsies of different phenotypes of gastroesophageal reflux disease: a cross-sectional study.

BMC Gastroenterol 2021 May 3;21(1):201. Epub 2021 May 3.

Inflammatory Bowel Disease Clinic, Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga #15. Col. Sección XVI, CP 14000, México City, D.F., Mexico.

Background: The clinical endoscopic phenotypes of gastroesophageal reflux disease (GERD) are classified as Barrett's esophagus (BE), erosive esophagitis (EE) and non-erosive gastroesophageal reflux disease (NERD). NERD is subclassified as abnormal acid exposure (AAE) and normal acid exposure (NAE) based on pH monitoring study results. The aim of this study was to characterize genes involved in the pathophysiology and immune response of GERD. Read More

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Carbonic Anhydrases II, IX, and XII in Reflux Esophagitis.

Dig Dis Sci 2021 Apr 30. Epub 2021 Apr 30.

Cancer and Translational Medicine Research Unit, Medical Research Center Oulu, University of Oulu and Oulu University Hospital, 90014, Oulu, Finland.

Background: The pathogenesis of gastroesophageal reflux disease (GERD) has not been resolved in detail. Esophageal epithelial cells provide resistance to acidic reflux via several mechanisms, many of which involve buffering acid with bicarbonate and transporting protons. Carbonic anhydrases (CAs) are enzymes that control the acid-base balance by catalyzing the reversible hydration of carbon dioxide to produce bicarbonate and hydrogen ions. Read More

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The Effects of Patient Demographics on Outpatient Endoscopy Utilization in Children with Eosinophilic Esophagitis.

J Pediatr Gastroenterol Nutr 2021 Apr 28. Epub 2021 Apr 28.

Indiana University School of Medicine/Riley Hospital for Children, Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, 705 Riley Hospital Dr. ROC 4210, Indianapolis, IN 46202 Indiana University School of Medicine/Riley Hospital for Children, Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition Indiana University School of Medicine/Riley Hospital for Children, Department of Pediatrics, Division of Asthma and Allergy.

Objectives: Eosinophilic esophagitis (EoE) is a chronic inflammatory disease of the esophagus that requires esophagogastroduodenoscopy (EGD) for diagnosis and treatment monitoring. We aimed to identify frequency of endoscopic monitoring in children with EoE and observe the effect of age, race, socioeconomic factors, and atopy on the rate of endoscopy.

Methods: We queried the Pediatric Health Information System over a 15-year period for ambulatory EGDs in children with EoE. Read More

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Esophagitis Dissecans Superficialis in Children.

J Pediatr Gastroenterol Nutr 2021 Apr 28. Epub 2021 Apr 28.

Division of Pediatric Gastroenterology, Childrens Medical Center, Dallas, TX Department of Pediatrics Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX.

Objectives: Esophagitis dissecans superficialis (EDS) is a desquamative disorder of the superficial esophageal epithelium with variable clinical characteristics. Endoscopically there is an appearance of superficial peeling of sheets of epithelium. Histologically there is two-toned epithelium with coagulative necrosis of the superficial epithelium. Read More

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Manometric changes of the esophagus in morbidly obese patients.

Exp Ther Med 2021 Jun 14;21(6):604. Epub 2021 Apr 14.

5th Clinical Department, Gastroenterology and Internal Medicine Discipline, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.

This prospective study aimed to determine the manometric pattern and the prevalence of esophageal dysmotility in 79 morbidly obese patients selected for laparoscopic sleeve gastrectomy. After clinical evaluation and upper gastrointestinal endoscopy, high-resolution esophageal manometry was performed. The esophageal peristalsis, lower esophageal sphincter (LES) basal pressure, and LES relaxation were evaluated. Read More

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Rising trend in p​ediatric eosinophilic esophagitis incidence in Spain: Results of a prospective study 2014-16.

Pediatr Allergy Immunol 2021 May 1. Epub 2021 May 1.

Pediatrics Department, Hospital U. Puerta de Hierro, Majadahonda, Universidad Autónoma de Madrid, Madrid, Spain.

Objectives: The rate of eosinophilic esophagitis (EoE) diagnosis is increasing. This study aims to determine the incidence of EoE in the pediatric population residing in the southwestern Madrid and to analyze whether absolute monthly pollen counts, modified or not by the principal atmospheric pollutants, are associated with it.

Methods: A cross-sectional study on prospectively recruited patients was designed to calculate the incidence of EoE in children aged under 15 years who were diagnosed between September 2014 and August 2016 in twelve hospitals. Read More

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Hypo-fractionated radiotherapy with concurrent chemotherapy for locoregional recurrence of non-small cell lung cancer after complete resection: A prospective, single-arm, phase II study (GASTO-1017).

Lung Cancer 2021 Apr 27;156:82-90. Epub 2021 Apr 27.

Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China; Lung Cancer Institute of Sun Yat-sen University, Guangzhou, China; Guangdong Association Study of Thoracic Oncology, Guangzhou, China. Electronic address:

Objectives: To explore the efficacy and toxicities of split-course hypo-fractionated radiotherapy with concurrent chemotherapy (HFRT-CHT) with intensity modulated radiotherapy (IMRT) technique in non-small cell lung cancer (NSCLC) patients with postoperative locoregional recurrence (LRR).

Materials And Methods: NSCLC patients were eligible if confirmed as LRR disease without distant metastasis after complete resection. HFRT-CHT using IMRT technique was administered with 51 Gy in 17 fractions or 40 Gy in 10 fractions as the first course followed by a break. Read More

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