18,459 results match your criteria Esophagitis


Laparoscopic sleeve gastrectomy and gastroesophageal reflux.

Rom J Intern Med 2018 Dec;56(4):227-232

"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

The prevalence of obesity is rising, becoming a medical problem worldwide. Also GERD incidence is higher in obese patients compared with normal weight, with an increased risk of 2.5 of developing symptoms and erosive esophagitis. Read More

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December 2018

Association of Chemoradiotherapy With Outcomes Among Patients With Stage I to II vs Stage III Small Cell Lung Cancer: Secondary Analysis of a Randomized Clinical Trial.

JAMA Oncol 2018 Dec 6:e185335. Epub 2018 Dec 6.

Division of Cancer Sciences, University of Manchester, Manchester, United Kingdom.

Importance: There is limited evidence to guide stage I to II small cell lung cancer (SCLC) treatment.

Objective: To examine the characteristics and outcomes among patients with stage I to II SCLC treated with modern chemoradiotherapy.

Design, Setting, And Participants: In this post hoc secondary analysis of the Concurrent Once-Daily vs Twice-Daily Radiotherapy Trial (CONVERT), a multicenter phase 3 trial conducted in patients with limited-stage SCLC from April 7, 2008, to November 29, 2013, patients with TNM stage I to II SCLC were compared with those with stage III disease. Read More

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December 2018
1 Read

Changes in the Distal Esophageal Microbiota in Chinese Patients with Reflux Esophagitis.

J Dig Dis 2018 Dec 5. Epub 2018 Dec 5.

Digestive Department, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Objective: Changes in microbiota structure in the distal esophagus may be associated with the pathogenesis of gastroesophageal reflux disease. The composition of the distal esophageal microbiota between Chinese patients and healthy volunteers was compared through metagenomic high-throughput DNA sequencing and bioinformatic analyses.

Methods: Healthy volunteers (HV) and patients with reflux esophagitis (RE) were enrolled. Read More

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December 2018
5 Reads

Clinical features at baseline do not predict symptomatic placebo response in patients with eosinophilic esophagitis.

Clin Gastroenterol Hepatol 2018 Nov 28. Epub 2018 Nov 28.

Division of Gastroenterology, Mayo Clinic, Rochester, MN, USA.

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November 2018

A Quantitative Clinical Decision-support Strategy Identifying Which Oropharyngeal Head and Neck Cancer Patients may Benefit the Most from Proton Radiation Therapy.

Int J Radiat Oncol Biol Phys 2018 Nov 26. Epub 2018 Nov 26.

Institute for Onco-Physics, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Radiation Oncology, Montefiore Medical Center, Bronx, NY 10461, USA; Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address:

Purpose: Developing a quantitative decision-support strategy estimating the impact of normal tissue complications from definitive radiation therapy (RT) for head and neck cancer (HNC). We developed this strategy to identify oropharyngeal HNC patients that may benefit most from receiving proton RT.

Methods And Materials: Recent normal tissue complication probability (NTCP) models for dysphagia, esophagitis, hypothyroidism, xerostomia and oral mucositis were used to estimate NTCP for 33 oropharyngeal HNC patients previously treated with photon IMRT. Read More

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November 2018

An update on the latest chemical therapies for reflux esophagitis in children.

Expert Opin Pharmacother 2018 Nov 29:1-9. Epub 2018 Nov 29.

e Gastroenterology department , McGill University Health Centre , Montréal , Québec , Canada.

Introduction: Gastroesophageal reflux (GER), and its complicated form gastroesophageal reflux disease (GERD) is a common condition in infants and children. As GERD is often considered to cause extra-oesophageal symptoms in children and in the absence of standardized diagnostic and treatment algorithm, many children are inappropriately exposed to empirical anti-reflux treatments, with Acid-Suppressive Medications (ASM); mostly proton pump inhibitors (PPIs). Areas covered: The authors summarize the pharmacological management of pediatric GERD and discuss the efficacy of PPIs as randomized controlled trials have failed to demonstrate their clinical efficacy in the pediatric population. Read More

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November 2018
2 Reads

Systematic review of histological remission criteria in eosinophilic esophagitis.

JGH Open 2018 Aug 13;2(4):158-165. Epub 2018 Jun 13.

Allergy-Asthma-Immunology Clinic, Department of Pediatric and Adolescent Medicine Western Michigan University M.D. Homer Stryker School of Medicine Kalamazoo Michigan US.

Elemental diets, dietary elimination, and steroid therapies are the most common therapies in the clinical trials for eosinophilic esophagitis (EoE). Histological findings (usually reported as eosinophils per microscopic high-powered field [hpf]) remain the most common end-point used to define response. Yet, the threshold for defining "response" and "remission" are ill-defined among consensus guidelines and may vary from study to study. Read More

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August 2018
3 Reads

Adiponectin level changes among Egyptians with gastroesophageal reflux disease.

JGH Open 2018 Feb 28;2(1):21-27. Epub 2018 Jan 28.

Department of Internal Medicine, Faculty of Medicine AL-Azhar University Assiut Egypt.

Background And Aim: Visceral fat is an important endocrine organ that secretes different bioactive substances such as adipocytokines. The aim of this study was to investigate the adiponectin level changes among patients with erosive gastroesophageal reflux disease (GERD)and its consequence on pathogenesis.

Methods: In this study, 150 subjects were selected and divided into four groups: Group І ( = 40) were healthy individuals with an average body mass index and had no gastrointestinal tract symptoms; Group ІІ ( = 50) were patients with mild to moderate erosive esophagitis; Group ІІІ ( = 40) were patients with severe erosive esophagitis; and finally, Group ІV ( = 20) were patients with Barrett's esophagus. Read More

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February 2018
3 Reads

The Present Status and Future of Barrett's Esophageal Adenocarcinoma in Japan.

Digestion 2018 Nov 27:1-6. Epub 2018 Nov 27.

Division of Gastroenterological Surgery, Tokai University, Oiso, Japan.

Background: The incidence of esophageal adenocarcinoma in Europe and the United States rapidly increased from the latter half of the 1970s and exceeded that of esophageal squamous cell carcinoma in the latter half of the 1990s, currently accounting for approximately 60% of all esophageal carcinomas. Recently, its incidence has also increased in Japan, raising concerns that it will follow a course similar to that in Europe and the United States.

Summary: The incidence of esophageal adenocarcinoma in Japan was about 2% until the 1990s, but in recent years, it has risen to 6. Read More

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November 2018
3 Reads

Long-Term Efficacy of Peroral Endoscopic Myotomy for Patients with Achalasia: Outcomes with a Median Follow-Up of 36 Months.

Dig Dis Sci 2018 Nov 26. Epub 2018 Nov 26.

Department of Gastroenterology, First Affiliated Hospital of Zhejiang Chinese Medical University, 54 Youdian Road, Hangzhou, 310006, China.

Objective: This study aimed to evaluate the long-term efficacy of peroral endoscopic myotomy (POEM) for patients with achalasia.

Methods: Prospective data collected from 115 patients (median age 45 years; interquartile range 34-57) with achalasia who underwent POEM at the First Affiliated Hospital of ZheJiang Chinese Medical University with a median follow-up of 36 months were retrospectively analyzed. The Eckardt score and lower esophageal sphincter pressure changes were analyzed, and the gastroesophageal reflux was observed. Read More

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November 2018
1 Read

Variation in Endoscopic Activity Assessment and Endoscopy Score Validation in Adults with Eosinophilic Esophagitis.

Clin Gastroenterol Hepatol 2018 Nov 23. Epub 2018 Nov 23.

Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.

Background & Aims: Eosinophilic esophagitis (EoE) is assessed endoscopically (endoscopic activity), based on grades of edema, rings, exudates, furrows, and strictures (EREFS). We examined variations in endoscopic assessments of severity, developed and validated 3 EREFS-based scoring systems, and assessed responsiveness of these systems using data from a randomized placebo-controlled trial of patients with EoE.

Methods: For the development set, 5 gastroenterologists reviewed EREFS findings from 266 adults with EoE and provided endoscopist global assessment scores (EndoGA, scale of 0 to 10); variation (ΔEndoGA) was assessed using linear regression. Read More

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November 2018
6 Reads

The dysphagia stress test for rapid assessment of swallowing difficulties in esophageal conditions.

Neurogastroenterol Motil 2018 Nov 25:e13512. Epub 2018 Nov 25.

Division of Gastroenterology & Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Background: Esophageal dysphagia is a common symptom in gastroenterology practice. Current rapid assessment tools are limited to oropharyngeal dysphagia and do not translate well to esophageal conditions. We aim to create a novel tool, the dysphagia stress test (DST), to evaluate swallowing in patients with esophageal disease characterized by dysphagia. Read More

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November 2018
3 Reads

Eosinophilic Esophagitis.

Med Clin North Am 2019 Jan 1;103(1):29-42. Epub 2018 Nov 1.

Division of Gastroenterology and Hepatology, Department of Medicine, Center for Esophageal Diseases and Swallowing, Center for Gastrointestinal Biology and Disease, University of North Carolina School of Medicine, CB #7080, Room 4140, Bioinformatics Building, 130 Mason Farm Road, Chapel Hill, NC 27599-7080, USA. Electronic address:

Eosinophilic esophagitis (EoE) is a chronic disorder characterized by symptoms of esophageal dysfunction and esophageal inflammation with intraepithelial eosinophils. EoE represents an important cause of upper gastrointestinal morbidity. Primary care providers are pivotal for timely and accurate recognition of symptoms of eosinophilic esophagitis, for facilitating diagnoses through specialist referrals, and for understanding management strategies. Read More

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January 2019
4 Reads

Adding Acotiamide to Gastric Acid Inhibitors Is Effective for Treating Refractory Symptoms in Patients with Non-erosive Reflux Disease.

Dig Dis Sci 2018 Nov 21. Epub 2018 Nov 21.

Department of Gastroenterology and Hepatology, Shimane University Hospital, 89-1 Enyacho, Izumo, Shimane, 693-0021, Japan.

Background: Approximately 30% of patients who are treated with proton pump inhibitors (PPIs) for gastroesophageal reflux disease (GERD) experience persistent symptoms. No prokinetic agent regiments are useful for symptom relief.

Aims: This study was conducted to examine the effect of adding acotiamide to PPI or vonoprazan refractory GERD. Read More

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November 2018
4 Reads

Elective nodal irradiation or involved-field irradiation in definitive chemoradiotherapy for esophageal squamous cell cancer: a retrospective analysis in clinical N0 patients.

Curr Oncol 2018 Oct 31;25(5):e423-e429. Epub 2018 Oct 31.

Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong University, Jinan, P.R.C.

Objective: We compared failure patterns and survival after elective nodal irradiation (eni) or involved-field irradiation (ifi) in patients with thoracic esophageal squamous cell carcinoma (escc), clinical stage T2-4N0M0, to determine whether ifi is feasible for such patients.

Methods: Between 2005 and 2015, 126 patients with clinical stage T2-4N0M0 thoracic escc who received definitive concurrent chemoradiotherapy in Shandong Cancer Hospital and Institute and who had complete data, were analyzed retrospectively. Of those patients, 49 received ifi, and 77 received eni. Read More

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October 2018
4 Reads

Preoperative Gastroesophageal Reflux Disorder Is Associated With Increased Morbidity in Patients Undergoing Abdominal Surgery.

J Surg Res 2018 Dec 8;232:587-594. Epub 2018 Aug 8.

Department of Surgery, University of Virginia, Charlottesville, Virginia.

Background: In North America, the prevalence of gastroesophageal reflux disorder ranges from 18.1% to 27.8%. Read More

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December 2018
2 Reads

A case report of multiple anesthesia for pediatric surgery: 80 anesthesia applications in a period of 6 years.

BMC Anesthesiol 2018 Nov 20;18(1):175. Epub 2018 Nov 20.

Şişli Hamidiye Etfal Education and Research Hospital, Anesthesiology and Reanimation Department Halaskargazi Cad. Etfal Sok, Istanbul, Şişli, Turkey.

Background: The side and adverse effects of anesthesia and its neurotoxicity to children have become major concerns of anesthesiologists in recent years. Currently, no clinical trials have provided clear evidence indicating the suitable minimum age for a patient's first anesthetic application, importance of anesthesia duration, number of anesthetic applications or interval between two consecutive anesthesia applications. A very rare case concerning the side, adverse and neurotoxic effects of multiple anesthesia in a child is presented. Read More

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November 2018
2 Reads

Gastroesophageal Reflux in Asymptomatic Patients with Diabetes: An Impedance Study Diabetes, Obesity and Gastroesophageal Reflux.

Exp Clin Endocrinol Diabetes 2018 Nov 20. Epub 2018 Nov 20.

Division of Gastroenterohepatology, Department of Internal Medicine, Istanbul University, Istanbul Faculty of Medicine.

Introduction: Gastroesophageal reflux disease (GERD) is more frequent in patients with diabetes mellitus (DM).The aim of the present study was to evaluate GER in asymptomatic patients with DM using 24-h pH impedance.

Materials And Methods: 19 healthy controls and 35 patients with DM without typical GERD symptoms were enrolled in the study. Read More

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November 2018
9 Reads

Clinical prediction model for tumor progression in Barrett's esophagus.

Surg Endosc 2018 Nov 19. Epub 2018 Nov 19.

Upper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Norra Stationsgatan 67, Solna (L1:00), 171 76, Stockholm, Sweden.

Background: Individuals with Barrett's esophagus (BE) are at increased risk of high-grade dysplasia (HGD) and esophageal adenocarcinoma (EAC), but the cost-effectiveness of general surveillance of BE is low. This study aimed to identify a risk prediction model for tumor progression in individuals with BE based on age, sex, and risk factors found at upper endoscopy, enabling tailored surveillance.

Methods: This nested case-control study originated from a cohort of 8171 adults diagnosed with BE in 2006-2013 in the Swedish Patient Registry. Read More

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November 2018
8 Reads

A Distinct Esophageal mRNA Pattern Identifies Eosinophilic Esophagitis Patients With Food Impactions.

Front Immunol 2018 5;9:2059. Epub 2018 Nov 5.

Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, United States.

Eosinophilic esophagitis (EoE), a Th2-type allergic immune disorder characterized by an eosinophil-rich esophageal immune infiltrate, is often associated with food impaction (FI) in pediatric patients but the molecular mechanisms underlying the development of this complication are not well understood. We aim to identify molecular pathways involved in the development of FI. Due to large variations in disease presentation, our analysis was further geared to find markers capable of distinguishing EoE patients that are prone to develop food impactions and thus expand an established medical algorithm for EoE by developing a secondary analysis that allows for the identification of patients with food impactions as a distinct patient population. Read More

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November 2018
7 Reads

Dichloromethane Extracts of Kom. Alleviates Esophagus Damage in Acute Reflux Esophagitis-Induced Rats by Anti-Inflammatory Activities.

Int J Mol Sci 2018 Nov 16;19(11). Epub 2018 Nov 16.

Department of Crop Science & Biotechnology, Chonbuk National University, Jeonju 54896, Korea.

Reflux esophagitis (RE) is a gastrointestinal disease caused by the reflux of gastric acid and stomach contents, and it leads to esophageal damage. Therefore, it is necessary to study the improvement of esophageal damage on a RE-induced model. The present study was accomplished to demonstrate the protective effects of a dichloromethane fraction of (DGK) plant on esophageal damage in an acute RE rat model. Read More

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November 2018
3 Reads

Consortium for Eosinophilic Researchers (CEGIR): Advancing the Field of Eosinophilic GI Disorders Through Collaboration.

Gastroenterology 2018 Nov 16. Epub 2018 Nov 16.

Division of Allergy and Immunology, Department of Pediatrics, University of Cincinnati College of Medicine/Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

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November 2018
2 Reads

Eosinophilic Esophagitis Mimicking Candida Esophagitis.

Intern Med 2018 Nov 19. Epub 2018 Nov 19.

Department of Clinical Laboratory Medicine (Diagnostic Pathology), Shiga University of Medical Science, Japan.

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November 2018

Histologic similarities in children with eosinophilic esophagitis and PPI-responsive esophageal eosinophilia.

J Allergy Clin Immunol 2018 Nov 13. Epub 2018 Nov 13.

Section of Pediatric Gastroenterology, Hepatology and Nutrition, Digestive Health Institute, Children's Hospital Colorado, Aurora, Colorado, USA; Gastrointestinal Eosinophilic Diseases Program, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA; Institute of Immunology, Department of Biology, Maynooth University, Maynooth, Co Kildare, Ireland.

The EPX histologic scoring system can be used to differentiate children with EoE and PPI-REE relative to GERD, supporting the relationship between these 2 groups and enhancing current diagnostic and treatment approaches. Read More

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November 2018
1 Read

Anti-interleukin (IL)-5 as a steroid-sparing agent in chronic eosinophilic pneumonia.

J Asthma 2018 Nov 16:1-5. Epub 2018 Nov 16.

c Medicine , University at Buffalo , Buffalo , New York , USA.

Introduction: Anti-interleukin (IL)-5 therapy is a novel drug class clinically effective in patients with diverse eosinophil-related disorders such as allergic eosinophilic asthma, eosinophilic granulomatosis with polyangiitis (EGPA), nasal polyposis, eosinophilic COPD, and other non-pulmonary disorders such as eosinophilic esophagitis. Chronic eosinophilic pneumonia (CEP) is a steroid responsive disorder, however, relapses are common following corticosteroid tapering.

Case Study: We present the case of a 42-year-old woman with steroid-dependent relapsing CEP successfully treated with anti-IL-5 antibody. Read More

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November 2018

Radicality of proximal gastrectomy - a rewiev.

Authors:
P Lochman J Páral

Rozhl Chir 2018 ;97(8):360-367

Although the incidence of gastric cancer is decreasing worldwide, the number of esophagogastric junction and upper-third gastric carcinomas is gradually growing. This is due to an increasing incidence of reflux esophagitis with Barrett's metaplasia and successful eradication of Helicobacter pylori infection. Treatment options for these tumors include proximal gastrectomy. Read More

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January 2018
1 Read

Esophageal dysplasia and adenocarcinoma: a study with double immunostaining for intestinal and gastric markers.

Cesk Patol 2018 ;54(2):81-85

Columnar lined esophagus is a complication of long term gastroesophageal reflux disease and the main precursor of esophageal adenocarcinoma. Incomplete intestinal metaplasia in reflux esophagitis represents one of the most important risk factors for neoplastic transformation through the metaplasia-dysplasia-adenocarcinoma sequence. However, recent studies suggest that cardiac type mucosa also shows molecular abnormalities which are similar to those of incomplete intestinal metaplasia. Read More

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January 2018
3 Reads

Approach to the Assessment and Management of Adult Patients With Atopic Dermatitis: A Consensus Document. Section III: Evaluation of Atopic Dermatitis Patients for Comorbidities.

J Cutan Med Surg 2018 Nov/Dec;22(1_suppl):17S-20S

Atopic dermatitis (AD) is often associated with other atopic diseases, including asthma, allergic rhinitis, atopy-associated eye disorders, and eosinophilic esophagitis. Depression and anxiety are also comorbidities to AD that significantly affect quality of life and should be screened for in patients with AD. Links to other comorbidities such as cardiovascular disease and malignancy are considered inconclusive, but patient counselling and screening may be appropriate in some patients. Read More

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November 2018
6 Reads

Clinical and endoscopic response to high dose rate endobronchial brachytherapy in malignant lung tumors: A single centre experience.

South Asian J Cancer 2018 Oct-Dec;7(4):267-269

Department of Radiation Oncology, Cancer Research Institute, SRHU, Dehradun, Uttarakhand, India.

Purpose: The aim of the study was to evaluate the short-term clinical, endoscopic response, and acute toxicities in endobronchial cancer treated with high-dose-rate endobronchial brachytherapy (HDR-EB).

Materials And Methods: Thirty patients of advanced endobronchial cancers were treated with HDR-EB. Brachytherapy was delivered at a depth of 1 cm from the source axis at weeks 1, 2, and 3 with 7 Gy per fraction. Read More

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November 2018
6 Reads

[Gastrointestinal innovations].

MMW Fortschr Med 2018 11;160(Suppl 3):58-63

Medizinische Klinik und Poliklinik II, Klinikum der Universität München, Marchioninistr. 15, D-81377, München, Deutschland.

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November 2018
1 Read

Mononeuritis multiplex: an uncommon neurological manifestation of cytomegalovirus reactivation in an HIV-infected patient.

BMC Infect Dis 2018 Nov 12;18(1):554. Epub 2018 Nov 12.

Infectious Diseases Department, Centro Hospitalar de São João, Alameda Professor Hernâni Monteiro, 4200-319, Porto, Portugal.

Background: Cytomegalovirus (CMV) reactivation with neurological involvement in patients with acquired immunodeficiency syndrome (AIDS) is increasingly rare since the introduction of antiretroviral therapy (ART). Manifestations include encephalitis, myelitis, polyradiculopathy and, less commonly, mononeuritis multiplex (MNM). We report a case of disseminated CMV disease with gastrointestinal and peripheral and central nervous system involvement in a patient with AIDS, manifesting primarily as MNM. Read More

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November 2018
5 Reads

Germination of pollen grains in the esophagus of individuals with eosinophilic esophagitis.

Clin Exp Allergy 2018 Nov 12. Epub 2018 Nov 12.

Biodiversity and Environmental Management, University of León, León, Spain.

Background: Eosinophilic esophagitis (EoE) is characterized by esophageal dysfunction and, histologically, by eosinophilic inflammation. There is no a clear etiologic treatment. EoE exacerbations are often seasonal. Read More

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November 2018
1 Read

Esophageal Compliance Quantifies Epithelial Remodeling in Pediatric Patients with Eosinophilic Esophagitis.

J Pediatr Gastroenterol Nutr 2018 Nov 8. Epub 2018 Nov 8.

Division of Gastroenterology Hepatology and Nutrition, UCSD.

Background: The management of eosinophilic esophagitis (EoE) relies on the severity of esophageal eosinophilia, yet there is poor evidence of its prediction of esophageal fibrotic remodeling and subsequent complications such as dysphagia, food impactions, or strictures. Functional Luminal Impedance (FLIP) has had limited use in pediatric patients to evaluate esophageal tissue mechanics. We aimed to standardize the FLIP technique and to measure esophageal compliance in children with EoE in comparison to controls. Read More

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November 2018
1 Read

Hypofractionated Concomitant Chemoradiation in Inoperable Locally Advanced Non-small Cell Lung Cancer: A Report on 100 Patients and a Systematic Review.

Clin Oncol (R Coll Radiol) 2018 Nov 8. Epub 2018 Nov 8.

Department of Clinical Oncology, Northern Centre for Cancer Care, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK; Newcastle University, Newcastle upon Tyne, UK.

Aims: Concomitant chemoradiation is the standard of care in patients with inoperable non-small cell lung cancer. The purpose of this study was to analyse the survival outcome and toxicity data of using hypofractionated chemoradiation.

Materials And Methods: One hundred patients were treated from June 2011 to November 2016. Read More

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November 2018

Acute esophageal necrosis (black esophagus) complicating calcific uremic arteriolopathy
.

Clin Nephrol 2018 Nov 12. Epub 2018 Nov 12.

The current case report describes a chronic hemodialysis patient presenting with painful penile ulceration that was clinically and histologically proven to be related to calcific uremic arteriolopathy. The patient subsequently developed severe upper gastrointestinal bleeding that was both endoscopically and histologically shown to be due to acute esophageal necrosis (AEN), also known as necrotizing esophagitis and "black esophagus". AEN is a rare condition characterized by diffuse necrosis of the esophageal mucosa. Read More

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November 2018
5 Reads

Eosinophil progenitor levels correlate with tissue pathology in pediatric eosinophilic esophagitis.

J Allergy Clin Immunol 2018 Nov 9. Epub 2018 Nov 9.

Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio. Electronic address:

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November 2018
4 Reads

Early outcomes of breast cancer patients treated with post-mastectomy uniform scanning proton therapy.

Radiother Oncol 2018 Nov 7. Epub 2018 Nov 7.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, United States. Electronic address:

Background: Postmastectomy proton radiotherapy improves normal tissue sparing in comparison to photon-based approaches. Several studies have reported dosimetry comparison and tolerable acute toxicity profile with limited follow-up. We report our institutional experience of postmastectomy proton radiation including clinical efficacy and toxicities. Read More

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November 2018
20 Reads

Immunology of the ancestral differences in eosinophilic esophagitis.

Ann Allergy Asthma Immunol 2018 Nov 7. Epub 2018 Nov 7.

Division of Allergy and Immunology, The Children's Hospital of Philadelphia Department of Pediatrics, Perelman School of Medicine at University of Pennsylvania, Philadelphia, Pennsylvania.

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November 2018
2.600 Impact Factor

Salvage Stereotactic Body Radiation Therapy for Locally Recurrent Previously Irradiated Head and Neck Squamous Cell Carcinoma: An Analysis from the RSSearch® Registry.

Cureus 2018 Aug 31;10(8):e3237. Epub 2018 Aug 31.

Department of Radiation Oncology, St. Mary's Medical Center, Huntington, USA.

Objectives To report on overall survival (OS), local control (LC), dose-outcome relationships, and related toxicities following stereotactic body radiation therapy (SBRT) for locally recurrent, previously irradiated squamous cell carcinoma of the head and neck (rSCCHN). Methods We queried the prospectively-maintained RSSearch® Registry for patients with rSCCHN treated with five-fraction SBRT from January 2008 to November 2016. Patients with non-squamous cell histology, missing registry data regarding prior irradiation, those treated with less than five fractions of SBRT, and those treated with SBRT in primary or boost settings were excluded. Read More

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August 2018
2 Reads

Optimal Biopsy Protocol to Evaluate Histological Effectiveness of Proton Pump Inhibitor Therapy in Patients with Eosinophilic Esophagitis.

Digestion 2018 Nov 8:1-8. Epub 2018 Nov 8.

Department of Diagnostic Pathology, Osaka City University Graduate School of Medicine, Osaka, Japan.

Objective: Recent guidelines propose that both proton pump inhibitor (PPI) responders and nonresponders are included in eosinophilic esophagitis (EoE). Although multiple biopsies should be required to diagnose EoE because of patchy distribution of esophageal eosinophils, it is unclear whether multiple biopsies are required to evaluate histological effectiveness of PPI therapy. This study aimed to determine the optimal biopsy protocol after PPI therapy in patients with EoE. Read More

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November 2018
8 Reads

Basal lower esophageal sphincter pressure in gastroesophageal reflux disease: An ignored metric in high-resolution esophageal manometry.

Indian J Gastroenterol 2018 Sep 6;37(5):446-451. Epub 2018 Nov 6.

Department of Gastroenterology, Gleneagles Global Health City, 439, Medavakkam Road, Perumbakkam, Cheran Nagar, Chennai, 600 100, India.

Manometry and 24-h pH interpretation have seldom been studied. Our aim was to study these parameters as gold standard in reflux disease and to identify predictors of pathological acid reflux. Retrospective case record review of all patients with reflux disease evaluated using endoscopy, manometry, and 24-h pH testing from 2010 to 2016. Read More

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September 2018
8 Reads

An Ethanolic Extract of Root Alleviates Reflux Esophagitis and Modulates NF-B Signaling.

Evid Based Complement Alternat Med 2018 8;2018:1834681. Epub 2018 Oct 8.

Sunchang Research Institute of Health and Longevity, Ingye-myeon Indeok-ro, Sunchang-gun, Jeollabuk-do 56015, Republic of Korea.

Reflux esophagitis (RE) is a kind of gastroesophageal reflux disease, of which an esophageal inflammatory lesion is caused by the contents of the stomach and duodenum flowing back into the esophagus. is a plant possessing both nutritional and medicinal properties. In our study, we investigated the inhibition effect of inflammation of root extract (AHE) on inflammatory RAW264. Read More

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October 2018
6 Reads

Is There a Reason for the Proton Pump Inhibitor? An Assessment of Prescribing for Residential Care Patients in British Columbia.

Can J Hosp Pharm 2018 Sep-Oct;71(5):295-301. Epub 2018 Oct 31.

, BSc(Pharm), PharmD, is with Lower Mainland Pharmacy Services, Surrey British Columbia, and the Therapeutics Initiative (The University of British Columbia), Vancouver, British Columbia.

Background: The use of proton pump inhibitors (PPIs) may cause significant harm to patients in the residential care setting, as these patients are often frail with multiple morbidities. The extent of non-evidence-based use of PPIs in residential care sites of the Fraser Health Authority in British Columbia is unknown.

Objective: To determine the proportion of non-evidence-based use of PPI therapy for residential care patients of the Fraser Health Authority. Read More

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October 2018
4 Reads

Challenges in managing patients referred for eosinophilic esophagitis: A telephone survey and retrospective review.

Allergy Asthma Proc 2018 Nov;39(6):449-455

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Pennsylvania State College of Medicine, Hershey, Pennsylvania.

Eosinophilic esophagitis (EoE) in patients referred to allergists can be difficult to manage. This is due to multiple factors, including overlaps in presentation with gastroesophageal reflux disease and proton-pump inhibitor responsive eosinophilia, remaining uncertainties regarding the role of different forms of allergy testing, and a variety of patient adherence issues. To highlight, in an objectively studied fashion, complications that can be faced when managing patients referred for EoE. Read More

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November 2018
3 Reads

Medical Disimpaction for Children With Organic Esophageal Foreign Body in the Era of Eosinophilic Esophagitis.

Pediatr Emerg Care 2018 Nov 5. Epub 2018 Nov 5.

From the Princess Margaret Hospital for Children and Perth Children's Hospital, Perth, Australia.

Objective: Esophageal foreign body impaction (EFBI) is a common presentation in pediatric emergency medicine. Interventions (medical or endoscopic) are often required because of the severity of symptoms and risk of complications. Use of medical disimpaction (MD) such as glucagon injections and effervescent agents (eg, carbonated beverages) has been well described in adults; however, there are limited data in the pediatric literature. Read More

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November 2018
6 Reads

Esophageal foreign bodies in adults: systematic review of the literature.

Scand J Gastroenterol 2018 Nov 5:1-8. Epub 2018 Nov 5.

a Department of Biomedical Science for Health, Division of General Surgery IRCCS Policlinico San Donato , University of Milan , Milan , Italy.

Objective: Esophageal Foreign Body (FB) impaction represents a major challenge for healthcare providers. Aim of this systematic review was to analyse the current literature evidence on prevalence, presentation, treatment, and outcomes of impacted esophageal FB.

Materials And Methods: Literature search was conducted between 2000 and 30th June 2018 according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. Read More

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November 2018
6 Reads

Pathophysiology of eosinophilic esophagitis: recent advances and their clinical implications.

Expert Rev Clin Immunol 2018 Nov 3:1-13. Epub 2018 Nov 3.

a Division of Allergy & Immunology , Children's Hospital of Philadelphia , Philadelphia , PA , USA.

Introduction: Diagnostic and therapeutic strategies in eosinophilic esophagitis (EoE) are evolving. New knowledge regarding the pathophysiology of EoE has been the foundation for updated diagnostic recommendations and new therapeutic trials. Areas covered: We performed structured literature searches in Medline and PubMed, Cochrane meta-analyses, and abstracts of international congresses to review therapeutic approaches for EoE in July 2018. Read More

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November 2018
10 Reads

[Gastroesophageal reflux disease is associated with high risk of obstructive sleep apnea syndrome].

Zhonghua Nei Ke Za Zhi 2018 Nov;57(11):824-829

Department of Gastroenterology, The Central Hospital of Longhua District, Shenzhen 518110, China.

To investigate the relationship between gastroesophageal reflux disease (GERD) and obstructive sleep apnea syndrome(OSAS). Patients diagnosed as GERD and healthy controls without GERD related symptoms or endoscopic esophagitis were enrolled from October 2017 and December 2017. All subjects completed Berlin Questionaire to assess the risk of OSAS. Read More

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November 2018
4 Reads