19,540 results match your criteria Esophagitis


Clinical outcomes of laparoscopic and endoscopic cooperative surgery for submucosal tumors on the esophagogastric junction: a retrospective single-center analysis.

Gastric Cancer 2020 May 31. Epub 2020 May 31.

Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.

Background: Laparoscopic and endoscopic cooperative surgery (LECS) technique for gastric submucosal tumor (SMT) has developed, but treatment of SMT on the esophagogastric junction (EGJ) remains technically difficult because excessive resection may result in postoperative transformation of the EGJ and cause stenosis, and intervention to lower esophageal sphincter may result in gastroesophageal reflux. The study aim was to evaluate the feasibility and safety of LECS for SMT on the EGJ.

Methods: Between September 2012 and December 2018, LECS was performed for 21 patients with SMTs on the EGJ. Read More

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http://dx.doi.org/10.1007/s10120-020-01089-xDOI Listing

Vitamin deficiencies in pediatric Eosinophilic Esophagitis: a systematic review.

Pediatr Allergy Immunol 2020 May 31. Epub 2020 May 31.

Weill Cornell Medicine, New York, NY, USA.

Nutritional deficiencies are seen in patients with food allergy. Low Vitamin D levels have been found in patients with atopic conditions. Eosinophilic esophagitis (EoE) is a chronic immune antigen mediated disease found to be highly associated in patients with atopic disease and treated with dietary elimination with recommendations to utilize a dietician to prevent nutritional deficiencies. Read More

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http://dx.doi.org/10.1111/pai.13297DOI Listing

Experience with Esophageal Granular Cell Tumors: Clinical and Endoscopic Analysis of 22 Cases.

Dig Dis Sci 2020 May 30. Epub 2020 May 30.

Shanxi Medical University, Taiyuan, 030001, Shanxi, China.

Background: Esophageal granular cell tumors (GCTs) are rare tumors. Differences in reports on the clinical features of GCTs in the esophagus and some controversies about the diagnostic strategy for esophageal GCTs exist.

Objectives: We aimed to investigate the clinical features and diagnosis of esophageal GCTs. Read More

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http://dx.doi.org/10.1007/s10620-020-06337-9DOI Listing

Trends in gastroesophageal reflux disease in Japanese children and adolescents.

Pediatr Int 2020 May 30. Epub 2020 May 30.

Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.

Background: Although the prevalence of gastroesophageal reflux disease (GERD) has been increasing in Japan, little is known concerning the prevalence and severity of GERD in pediatric patients. This study compared the prevalence and severity of endoscopically proven GERD in pediatric patients over a 15-year period seen at an endoscopy center in Japan.

Methods: This was a retrospective chart review of Japanese children between the ages of 5 and 18 years undergoing esophagogastroduodenoscopy for upper gastrointestinal symptoms or anemia between 2005 and 2019. Read More

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http://dx.doi.org/10.1111/ped.14324DOI Listing

Targeted Therapies for Eosinophilic Gastrointestinal Disorders.

BioDrugs 2020 May 29. Epub 2020 May 29.

Division of Hospital Pharmacy, Hospital General de Tomelloso, Tomelloso, Spain.

The growing recognition of eosinophilic gastrointestinal disorders has revealed the limitations of current treatment (mainly based on dietary modification and corticosteroids), and include refractoriness, high recurrence rates, and the need for long-term therapy. Research efforts, mainly in eosinophilic esophagitis (EoE), have unveiled essential pathophysiological mechanisms leading to these disorders, which bear some similarities to those of atopic manifestations and are shared by eosinophilic gastroenteritis (EGE) and eosinophilic colitis (EC). Novel targeted therapies, some imported from bronchial asthma and atopic dermatitis, are currently being assessed in EoE. Read More

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http://dx.doi.org/10.1007/s40259-020-00427-wDOI Listing

[Recommendations for the diagnosis and practical management of paediatric eosinophilic oesophagitis].

An Pediatr (Barc) 2020 May 26. Epub 2020 May 26.

Asociación Española de Esofagitis Eosinofílica (AEDESEO).

Eosinophilic oesophagitis is an emerging and chronic disorder mediated by the immune system, and is characterised by symptoms of oesophageal dysfunction and inflammation with isolated eosinophil infiltration in the oesophagus. It is more common in males and in atopic subjects, and the symptoms vary with age. In younger children, there is vomiting, abdominal pain and dietary problems, with dysphagia and food impaction in older children and adolescents. Read More

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http://dx.doi.org/10.1016/j.anpedi.2020.04.007DOI Listing

Immune Dysregulation after Pediatric Heart Transplantation.

J Heart Lung Transplant 2020 Apr 30;39(4S):S455. Epub 2020 Mar 30.

Cardiology, The Hospital for Sick Children, Toronto, ON, Canada.

Purpose: There has been greater recognition of allergy and autoimmune disease in pediatric solid organ transplantation, however, their relationship with pediatric heart transplant is unclear. The purpose of this study was to explore post heart transplant immune dysregulation.

Methods: Retrospective chart review was carried out at a single center on children less than 18 years of age, transplanted between 2000 and 2018, who were at least 1 year post heart transplant without any history of immune dysregulation before transplant. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.289DOI Listing

Cytomegalovirus-associated esophageal stricture as a manifestation of the immune reconstitution inflammatory syndrome.

IDCases 2020 11;21:e00795. Epub 2020 May 11.

Department of Internal Medicine, Chris Hani Baragwanath Academic Hospital, Johannesburg, South Africa.

Cytomegalovirus (CMV) esophagitis is well described in immunocompromised individuals, however, esophageal stricture due to CMV is rare. CMV disease in the setting of the immune reconstitution inflammatory syndrome (IRIS) usually takes the form of an immune-recovery uveitis or retinitis. We describe a young female patient with HIV who developed an esophageal stricture due to CMV within 6 months of starting antiretroviral therapy (ART). Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242862PMC

Functional role of kallikrein 5 and proteinase-activated receptor 2 in eosinophilic esophagitis.

Sci Transl Med 2020 May;12(545)

Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229-3026, USA.

Eosinophilic esophagitis (EoE) is a chronic, food antigen-driven, inflammatory disease of the esophagus and is associated with impaired barrier function. Evidence is emerging that loss of esophageal expression of the serine peptidase inhibitor, kazal type 7 (SPINK7), is an upstream event in EoE pathogenesis. Here, we provide evidence that loss of mediates its pro-EoE effects via kallikrein 5 (KLK5) and its substrate, protease-activated receptor 2 (PAR2). Read More

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http://dx.doi.org/10.1126/scitranslmed.aaz7773DOI Listing

Predictive value of preoperative DeMeester score on conversion to Roux-en-Y gastric bypass for gastroeosophageal reflux disease after sleeve gastrectomy.

Surg Obes Relat Dis 2020 Apr 19. Epub 2020 Apr 19.

Clinique de Chirurgie Cancérologique Digestive et Endocrinienne, Institut des Maladies de l'Appareil Digestif, Centre Hospitalo-universitaire de Nantes (CHU) Hôtel-Dieu, Nantes, France; L'institut du thorax, INSERM, CNRS, UNIV Nantes, Nantes, France. Electronic address:

Background: Obesity is well known to increase the risk of gastroesophageal reflux disease (GERD). The impact of sleeve gastrectomy (SG) on GERD is still discussed but seems to be associated with the development of de novo GERD or the exacerbation of preexisting GERD.

Objective: The objective of this study was to evaluate the impact of preoperative pH monitoring, using the DeMeester score (DMS), on the risk of conversion to Roux-en-Y gastric bypass (RYGB) after SG. Read More

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http://dx.doi.org/10.1016/j.soard.2020.04.010DOI Listing

Gastrointestinal involvement of primary skin diseases.

J Eur Acad Dermatol Venereol 2020 May 26. Epub 2020 May 26.

Center for Research & Development, Kaohsiung Municipal Siaogang Hospital, Kaohsiung, Taiwan.

Less is known about gastrointestinal (GI) involvement of primary skin diseases due to the difference in embryology, histology, microbiology and physiology between integument and alimentary tract. Esophagus, following the oropharyngeal mucosa, is the most common GI segment affected by primary skin diseases, especially by eosinophilic esophagitis, lichen planus, and autoimmune bullous dermatoses like pemphigus vulgaris, mucosal membrane pemphigoid and epidermolysis bullosa acquisita. Eosinophilic esophagitis is an emerging chronic atopic disease with esophageal dysfunction as the typical presentation, and esophageal narrowing, rings and stricture as late complications. Read More

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http://dx.doi.org/10.1111/jdv.16676DOI Listing

Definitive re-irradiation of locally recurrent esophageal cancer after trimodality therapy in patients with a poor performance status.

Mol Clin Oncol 2020 Jul 11;13(1):27-32. Epub 2020 May 11.

Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital, Boston, MA 02115, USA.

There are few treatment guidelines for locally recurrent esophageal cancer after trimodality treatment (pre-operative chemoradiation followed by surgery) in patients with a poor performance status. The purpose of this single institutional, retrospective study was to evaluate the clinical outcomes and toxicities of definitive-intent re-irradiation for patients with recurrent esophageal cancer with a poor performance status [ECOG (Eastern Cooperative Oncology Group) ≥2]. Seven patients were identified with a median age of 74 years (range, 61-81 years). Read More

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http://dx.doi.org/10.3892/mco.2020.2044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241232PMC

Current updates in diagnosis and management of eosinophilic esophagitis.

Curr Probl Pediatr Adolesc Health Care 2020 May 20:100783. Epub 2020 May 20.

Department of Pediatric Gastroenterology, Dayton Children's Hospital, One Children's Plaza, Dayton, OH 45404, United States.

Eosinophilic esophagitis is a relatively new, moderately-well understood disease. It is one of the leading causes of dysphagia in the pediatric population. Thought to be triggered by food ingestion, it is distinctly different from food allergies. Read More

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http://dx.doi.org/10.1016/j.cppeds.2020.100783DOI Listing

Prevalence and clinical significance of esophageal abnormalities in children with celiac disease.

Dis Esophagus 2020 May 23. Epub 2020 May 23.

Centre for Child Health Research, Tampere University, Tampere, Finland, and Tampere University Hospital, Tampere, Finland.

Variable endoscopic and histological findings of esophageal lining are often detected in celiac disease, with unknown significance. We investigated the frequency and significance of such abnormalities in children. Macroscopic esophageal findings as reported by endoscopist and histological results by pathologist were compared between 316 celiac disease patients and 378 disease controls who had undergone upper gastrointestinal endoscopy with systematic esophageal biopsy sampling. Read More

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http://dx.doi.org/10.1093/dote/doaa033DOI Listing

Esophageal brachytherapy: Institut Gustave Roussy's experience.

Brachytherapy 2020 May 19. Epub 2020 May 19.

Radiotherapy Department, Gustave Roussy, Villejuif, France.

Purpose: Esophageal cancer is characterized by its propension to local evolution, which conditions prognosis and quality of life. Brachytherapy may be a therapeutic option for all stages of esophageal cancer.

Methods And Materials: This retrospective unicentric study included all consecutive patients treated for an esophageal high-dose-rate brachytherapy in our institution from 1992 to 2018. Read More

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http://dx.doi.org/10.1016/j.brachy.2020.04.002DOI Listing

Children With Gastroesophageal Reflux Disease Consume More Calories and Fat Compared to Controls of Same Weight and Age.

J Pediatr Gastroenterol Nutr 2020 Jun;70(6):808-814

Department of Gastroenterology and Hepatology, Federal Research Center of Nutrition, Biotechnology and Food Safety, Moscow, Russia.

Objective: The aim of the study was to compare the rates of nutrients consumption in children and adolescents with gastroesophageal reflux disease (GERD) compared to the control group without the disease.

Methods: Based on symptom evaluation and esophageal pH-impedance recordings patients were allocated on to GERD and control groups. All patients underwent esophagogastroscopy. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002652DOI Listing

Obesity and esophageal cancer: GERD, Barrett´s esophagus, and molecular carcinogenic pathways.

Expert Rev Gastroenterol Hepatol 2020 May 22:1-9. Epub 2020 May 22.

Department of Medicine and Surgery, University of North Carolina, Chapel Hill, NC, USA.

: Increases in the rates of esophageal adenocarcinoma (EAC) have paralleled rises in the prevalence of overweight and obesity. Despite not being fully understood, obesity-related EAC seems to have different carcinogenic pathways.: This comprehensive review will thoroughly evaluate the current literature, describing the underlying mechanisms that help understanding the strong association between obesity and esophageal cancer. Read More

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http://dx.doi.org/10.1080/17474124.2020.1764348DOI Listing

Laparoscopic Proximal Gastrectomy with Jejunal Interposition for Early Proximal Gastric Cancer.

J Gastrointest Cancer 2020 May 21. Epub 2020 May 21.

Department of General Surgery, Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, 217 Hong Bang, Ward 11, District 5, Ho Chi Minh City, Vietnam.

Purpose: Proximal gastrectomy has been more advantageous than total gastrectomy in early cancer in the upper third of the stomach. Jejunal interposition is a novel reconstruction technique to prevent reflux esophagitis and anastomotic stricture in proximal gastrectomy. The combination of these two procedures via laparoscopic approach is not yet widespread. Read More

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http://dx.doi.org/10.1007/s12029-020-00420-0DOI Listing

Reflux symptoms and oesophageal acidification in treated achalasia patients are often not reflux related.

Gut 2020 May 21. Epub 2020 May 21.

Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Objective: After treatment, achalasia patients often develop reflux symptoms. Aim of this case-control study was to investigate mechanisms underlying reflux symptoms in treated achalasia patients by analysing oesophageal function, acidification patterns and symptom perception.

Design: Forty treated achalasia patients (mean age 52. Read More

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http://dx.doi.org/10.1136/gutjnl-2020-320772DOI Listing

Outcomes of concurrent radiotherapy with weekly docetaxel and platinum-based chemotherapy in stage III non-small-cell lung cancer.

Cancer Radiother 2020 May 18. Epub 2020 May 18.

Department of radiation oncology, Cancer Center GF Leclerc, Dijon, France.

Purpose: The present study evaluated the outcomes of concurrent weekly docetaxel and platinum-based drug doublet in association with concurrent thoracic radiotherapy (TR) in the curative treatment of stage III locally advanced non-small-cell lung cancer (NSCLC).

Patients And Methods: Patients with stage IIIA/B NSCLC were retrospectively included. Patients received weekly docetaxel and either cisplatin or carboplatin intravenous injections during concurrent TR (60 to 66Gy). Read More

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http://dx.doi.org/10.1016/j.canrad.2019.09.009DOI Listing

Gastrointestinal Eosinophil Responses in a Longitudinal, Randomized Trial of Peanut Oral Immunotherapy.

Clin Gastroenterol Hepatol 2020 May 17. Epub 2020 May 17.

Sean N. Parker Center for Allergy and Asthma Research, Stanford University School of Medicine, Stanford, CA, United States. Electronic address:

Background & Aims: Gastrointestinal side effects are common during oral immunotherapy (OIT) and eosinophilic esophagitis (EoE) is a potential complication. We aimed to characterize eosinophilic gastrointestinal responses to peanut OIT, in which peanut protein is given orally, with incremental increases in dose over time.

Methods: Twenty adults with IgE-mediated peanut allergy were randomly assigned to groups given peanut OIT (n=15) or placebo (n=5); 1 additional subject withdrew before randomization. Read More

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http://dx.doi.org/10.1016/j.cgh.2020.05.019DOI Listing

Impact of Body Mass Index on Gastrointestinal Disorders: A Cross-sectional Study in a Pakistani Population.

Cureus 2020 Apr 18;12(4):e7722. Epub 2020 Apr 18.

Miscellaneous, Darul Sehat Hospital, Karachi, PAK.

Background:  The prevalence of obesity is on the rise globally. Pakistan ranks ninth out of 188 countries in terms of obesity. Literature regarding any potential role of obesity in gastrointestinal manifestations is limited. Read More

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http://dx.doi.org/10.7759/cureus.7722DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233932PMC

Phenotype and Natural History of Inflammatory Bowel Disease in Patients With Concomitant Eosinophilic Esophagitis.

Inflamm Bowel Dis 2020 May 20. Epub 2020 May 20.

Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.

Background: The co-occurrence of autoimmune diseases is well recognized. Though studies have suggested that eosinophilic esophagitis (EoE) is more common in patients with inflammatory bowel diseases (IBD), whether co-occurrence of EoE modifies natural history of IBD is unknown.

Methods: This was a retrospective case-control study at a referral center. Read More

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http://dx.doi.org/10.1093/ibd/izaa094DOI Listing

Combined partial posterior fundoplication with laparoscopic sleeve gastrectomy for morbid obese patients with symptomatic GERD. Video case report.

Int J Surg Case Rep 2020 May 8;71:34-36. Epub 2020 May 8.

Türkçapar Bariatrics, Obesity Center, İstanbul, Turkey.

İNTRODUCTION: Gastroesophageal reflux disease (GERD), which can be seen in up to 30% in postoperative series, is perhaps the most important complication of sleeve gastrectomy(SG). The general trend for patients who are planning to have bariatric surgery and have symptomatic GERD, Roux-en-Y gastric bypass is the most common choice. CASE PRESENTATION AND MANAGEMENT: A 42-year-old female patient with a body mass index of 36 kg/m presented to our clinic with obesity and symptomatic GERD. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.04.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235945PMC

Does weight gain, throughout 15 years follow-up after Nissen laparoscopic fundoplication, compromise reflux symptoms control?

Arq Bras Cir Dig 2020 18;33(1):e1488. Epub 2020 May 18.

School of Medicine, São Paulo University, São Paulo, SP, Brazil.

Background: Gastroesophageal reflux disease is defined by the abnormal presence of gastric content in the esophagus, with 10% incidence in the Western population, being fundoplication one treatment option.

Aim: To evaluate the early (six months) and late (15 years) effectiveness of laparoscopic fundoplication, the long term postoperative weight changes, as well as the impact of weight gain in symptoms control.

Methods: Prospective study of 40 subjects who underwent laparoscopic Nissen's fundoplication. Read More

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http://dx.doi.org/10.1590/0102-672020190001e1488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236326PMC

Applying the Eosinophilic Esophagitis Reference Scores to Different Aged Children.

J Pediatr Gastroenterol Nutr 2020 May 14. Epub 2020 May 14.

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Background & Aims: The eosinophilic esophagitis (EoE) endoscopic reference score (EREFS) was developed to analyze adults with EoE and has been successfully applied to a pediatric cohort. The present study compares EREFS scores in younger and older children with EoE.

Methods: The 99 patients were divided among three cohorts: 44 Active EoE (EoE-A); 16 EoE-remission (EoE-R), and 39 controls (esophageal dysfunction but < 15 eos/hpf). Read More

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http://dx.doi.org/10.1097/MPG.0000000000002788DOI Listing

A novel proangiogenic B cell subset is increased in cancer and chronic inflammation.

Sci Adv 2020 May 13;6(20):eaaz3559. Epub 2020 May 13.

Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.

B cells contribute to immune responses through the production of immunoglobulins, antigen presentation, and cytokine production. Several B cell subsets with distinct functions and polarized cytokine profiles have been reported. In this study, we used transcriptomics analysis of immortalized B cell clones to identify an IgG4 B cell subset with a unique function. Read More

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http://dx.doi.org/10.1126/sciadv.aaz3559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220305PMC

Gastroesophageal Reflux Disease, Obesity, and Roux-en-Y Gastric Bypass: Complex Relationship-a Narrative Review.

Authors:
Michel Suter

Obes Surg 2020 May 18. Epub 2020 May 18.

Department of Surgery, Riviera-Chablais Hospital, Rte des Tilles 6A, 1847, Rennaz, Switzerland.

Common, gastroesophageal reflux disease (GERD) is promoted by increased abdomino-thoracic pressure gradient and affects a large proportion of patients with obesity. Weight loss is one of the mainstays of conservative treatment. While fundoplication is recognized as the best surgical option in the general population, its results in severely obese individuals are controversial. Read More

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http://dx.doi.org/10.1007/s11695-020-04690-2DOI Listing

Pill-induced oesophagitis.

Authors:
Misbahuddin Syed

Postgrad Med J 2020 May 18. Epub 2020 May 18.

Internal and Hospital Medicine, Moffitt Cancer Center, Tampa, FL 33612, USA

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http://dx.doi.org/10.1136/postgradmedj-2020-137664DOI Listing

Modified laparoscopic sleeve gastrectomy with Rossetti antireflux fundoplication: results after 220 procedures with 24-month follow-up.

Surg Obes Relat Dis 2020 Apr 4. Epub 2020 Apr 4.

General and Oncologic Surgery Department, Centre of Bariatric Surgery, San Marco Hospital GSD, Zingonia, Italy.

Background: Gastroesophageal reflux disease (GERD), including erosive esophagitis, is highly prevalent in the obese population. Laparoscopic sleeve gastrectomy (LSG) is one of the most frequently performed bariatric procedures. The relationship between LSG and GERD has gained increasing attention. Read More

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http://dx.doi.org/10.1016/j.soard.2020.03.029DOI Listing

Clinical and anatomopathological features of eosinophilic oesophagitis in children and adults.

Allergol Immunopathol (Madr) 2020 May 15. Epub 2020 May 15.

Allergy Department, University Hospital Lozano Blesa, Zaragoza, Spain; Instituto de Investigación Sanitaria Aragón (IIS Aragón), Zaragoza, Spain.

Introduction: Eosinophilic oesophagitis (EoE) is a chronic clinical-pathological disorder with an immunological basis characterised by symptoms of oesophageal dysfunction and, histologically, eosinophilic inflammation.

Objective: To evaluate the clinical characteristics and differences in children and adults diagnosed with EoE in a tertiary level hospital.

Method: Descriptive, retrospective and cross-sectional study. Read More

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http://dx.doi.org/10.1016/j.aller.2020.03.009DOI Listing

IL-15 Expression Pattern in Atopic Dermatitis.

Int Arch Allergy Immunol 2020 May 18:1-5. Epub 2020 May 18.

Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland,

Background: An increased expression of interleukin (IL)-15, a cytokine with a key role in stimulating innate and adaptive immune cells, such as dendritic cells (DC), natural killer cells, and T cells, has been observed in infectious and inflammatory diseases, including autoimmune diseases as well as cancer. Atopic dermatitis (AD) is a common inflammatory skin disease characterized by a type 2 immune response.

Objective: To explore the expression of IL-15 and its pattern in AD skin. Read More

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http://dx.doi.org/10.1159/000508515DOI Listing

Quantification of accumulated dose and associated anatomical changes of esophagus using weekly Magnetic Resonance Imaging acquired during radiotherapy of locally advanced lung cancer.

Phys Imaging Radiat Oncol 2020 Jan 26;13:36-43. Epub 2020 Mar 26.

Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, United States.

Background And Purpose: Minimizing acute esophagitis (AE) in locally advanced non-small cell lung cancer (LA-NSCLC) is critical given the proximity between the esophagus and the tumor. In this pilot study, we developed a clinical platform for quantification of accumulated doses and volumetric changes of esophagus via weekly Magnetic Resonance Imaging (MRI) for adaptive radiotherapy (RT).

Material And Methods: Eleven patients treated via intensity-modulated RT to 60-70 Gy in 2-3 Gy-fractions with concurrent chemotherapy underwent weekly MRIs. Read More

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http://dx.doi.org/10.1016/j.phro.2020.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224352PMC
January 2020

Clinical and endoscopic characteristics of eosinophilic esophagitis in Japan: a case-control study.

Asia Pac Allergy 2020 Apr 23;10(2):e16. Epub 2020 Apr 23.

Department of General Internal Medicine 2, Kawasaki Medical School General Medical Center, Okayama, Japan.

Background: Eosinophilic esophagitis (EoE) is an allergy-associated clinicopathologic condition gaining an increasing amount of recognition in various areas of the world. While the clinical definition and characteristics may differ depending on country and region, sufficient studies have not yet been performed in Japan.

Objective: To assess the prevalence of EoE among the Japanese population and the clinical features associated with the disease. Read More

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http://dx.doi.org/10.5415/apallergy.2020.10.e16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203441PMC

Reconstruction Methods and Complications of Esophagogastrostomy and Jejunal Interposition in Proximal Gastrectomy for Gastric Cancer: A Meta-Analysis.

Gastroenterol Res Pract 2020 16;2020:8179254. Epub 2020 Jan 16.

Department of Surgical Oncology, Department of General Surgery, First Affiliated Hospital, China Medical University, Shenyang, China.

Background: Proximal gastrectomy is used for the treatment of primary gastric cancer by open or laparoscopic surgery in the upper third of the stomach. Esophagogastrostomy (EG) or jejunal interposition (JI) is widely used in various reconstruction methods after proximal gastrectomy. We conducted a meta-analysis of EG and JI for treatment of gastric cancer. Read More

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http://dx.doi.org/10.1155/2020/8179254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201443PMC
January 2020

Impact of ineffective esophageal motility on chemical clearance in patients with gastroesophageal reflux symptoms.

Dis Esophagus 2020 May 15. Epub 2020 May 15.

Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan.

Ineffective esophageal motility (IEM) is the most common manometric abnormality in gastroesophageal reflux disease (GERD). However, the impact of IEM on esophageal chemical clearance has not been fully investigated. This study aimed to determine the impact of IEM on esophageal chemical clearance in patients with GERD. Read More

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http://dx.doi.org/10.1093/dote/doaa026DOI Listing

Evidence for Cytoprotective Effect of Carbon Monoxide Donor in the Development of Acute Esophagitis Leading to Acute Esophageal Epithelium Lesions.

Cells 2020 May 12;9(5). Epub 2020 May 12.

Department of Physiology, Jagiellonian University Medical College, 31-531 Cracow, Poland.

Exposure to acidic gastric content due to malfunction of lower esophageal sphincter leads to acute reflux esophagitis (RE) leading to disruption of esophageal epithelial cells. Carbon monoxide (CO) produced by heme oxygenase (HMOX) activity or released from its donor, tricarbonyldichlororuthenium (II) dimer (CORM-2) was reported to protect gastric mucosa against acid-dependent non-steroidal anti-inflammatory drug-induced damage. Thus, we aimed to investigate if CO affects RE-induced esophageal epithelium lesions development. Read More

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http://dx.doi.org/10.3390/cells9051203DOI Listing

An anti-IL-13 antibody reverses epithelial-mesenchymal transition biomarkers in eosinophilic esophagitis: phase 2 trial results.

J Allergy Clin Immunol 2020 May 11. Epub 2020 May 11.

Celgene Corporation, Summit, NJ, U.S.

Background: Fibrostenosis, the most serious eosinophilic esophagitis (EoE) complication, is mediated by epithelial-mesenchymal transition (EMT). Transitioned cells contribute to pathogenesis by overproducing extracellular matrix.

Objective: To determine whether RPC4046 (anti‒IL-13 monoclonal antibody) modulates EMT biomarkers in biopsies from adults with active EoE in a substudy of a double-blind, placebo-controlled phase 2 trial. Read More

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http://dx.doi.org/10.1016/j.jaci.2020.03.045DOI Listing

Efficacy and Safety of Non-Vitamin K Anticoagulants for Atrial Fibrillation in Relation to Different Renal Function Levels: A Network Meta-Analysis.

Cardiovasc Ther 2020 22;2020:2683740. Epub 2020 Apr 22.

Department of Cardiology, Affiliated ZhongDa Hospital of Southeast University (HZ), Nanjing 210009, China.

Background: We performed a network meta-analysis (NMA) comparing the efficacy (stroke or systemic embolism) and safety (major bleeding) among different non-vitamin K antagonist oral anticoagulants (NOACs) in patients with atrial fibrillation (AF) and renal impairment, with the aim of recommending the proper drug and the dose based on renal function.

Methods: We searched PubMed, EMBASE, Web of Science, and Cochrane Library with the items "dabigatran, edoxaban, apixaban, rivaroxaban, warfarin, and atrial fibrillation" through August 2019. NMA was analyzed with R (version 3. Read More

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http://dx.doi.org/10.1155/2020/2683740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197012PMC

Comparison of the efficiency of two different proton pump inhibitor formula in treatment of patients with atypical gastroesophageal reflux disease: a prospective randomized study.

J Gastroenterol Hepatol 2020 May 13. Epub 2020 May 13.

Department of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan.

Background And Aim: The prospective, open-label, randomized study aims to compare the efficacy of lansoprazole, a fast orally disintegrating proton pump inhibitor (PPI), and dexlansoprazole, a dual delayed release PPI, in patients with atypical symptoms of gastroesophageal reflux disease (GERD).

Methods: Patients with atypical GERD symptoms with a total reflux symptom index score > 10 were eligible for enrollment. From February 2018 to December 2019, 232 subjects were randomly assigned (1:1 ratio) to receive oral lansoprazole, Takepron OD 30 mg, once daily before breakfast or oral dexlansoprazole, Dexilant 60 mg, once daily before breakfast for 8 weeks. Read More

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http://dx.doi.org/10.1111/jgh.15093DOI Listing

Ferrous Sulfate-Induced Esophageal Injury Leading to Esophagitis Dissecans Superficialis.

Case Rep Gastroenterol 2020 Jan-Apr;14(1):172-177. Epub 2020 Apr 17.

Division of Gastroenterology, Department of Medicine, Rutgers, New Jersey Medical School, Newark, New Jersey, USA.

Medication-induced esophagitis is a well-known but relatively rare clinical diagnosis, most common in patients with preexisting esophageal dysmotility, obstruction, or altered anatomy. Esophagitis dissecans superficialis (EDS) is a rare endoscopic finding characterized by sloughing of large fragments of the esophageal mucosal lining. The causes of EDS include prior trauma, heavy smoking history, ingestion of alcoholic and hot beverages, and immunosuppression. Read More

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http://dx.doi.org/10.1159/000506935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204857PMC

A Network Meta-Analysis of Randomized Controlled Trials on the Treatment of Eosinophilic Esophagitis in Adults and Children.

J Clin Gastroenterol 2020 May 8. Epub 2020 May 8.

Ludwig Maximilian University, Medical Clinic II, Munich.

Background: Network meta-analysis is used as a data synthesizer, incorporating direct and indirect evidence about treatments in a series of randomized control trials.

Objective: To evaluate the comparative efficacy of various treatments for eosinophilic esophagitis (EoE).

Methods: We performed a network meta-analysis to combine direct and indirect data to investigate the efficiency of drug therapies, which were evaluated in relevant randomized control trials for EoE. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001356DOI Listing

Approaches to diet therapy for eosinophilic esophagitis.

Curr Opin Gastroenterol 2020 May 7. Epub 2020 May 7.

Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid.

Purpose Of Review: The aim of this review is to highlight recent advances in dietary therapy for eosinophilic esophagitis (EoE).

Recent Findings: An empiric elimination diet step-up strategy is now well established as the initial approach for dietary treatment. The most common food triggers are by far cow's milk, followed by wheat and egg. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000645DOI Listing

Outcome and follow-up of patients requiring emergency oesophagoscopy for food bolus obstruction over a 5-year period.

Otolaryngol Pol 2019 Oct;74(3):29-32

Lister Hospital, Stevenage, United Kingdom.

Introduction: OFBO is a common occurrence in the emergency setting. Endoscopic removal via rigid or flexible oesophagoscopy is only performed following failure to pass the obstruction after a period of observation and medical management. Despite recommendations from the ESGE, there is currently a lack of high-quality evidence to support the diagnostic work-up of these patients. Read More

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http://dx.doi.org/10.5604/01.3001.0013.5261DOI Listing
October 2019

[Analysis on acupoint selection rules for reflux esophagitis].

Zhongguo Zhen Jiu 2020 May;40(5):557-64

Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.

The data mining technology was used to explore the acupoint selection rules for reflux esophagitis (RE), so as to provide references of clinical acupuncture for RE. The clinical literature of acupuncture for RE published before June 2019 was searched in Chinese journal full-text database (CNKI), SinoMed, Wanfang and VIP databases. The literature was selected according to the inclusion and exclusion criteria and acupoint prescriptions were extracted. Read More

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http://dx.doi.org/10.13703/j.0255-2930.20190706-0004DOI Listing

[Acute Necrotizing Esophagitis Occurred after Lung Resection for Lung Cancer].

Kyobu Geka 2020 Feb;73(2):121-123

Department of General Thoracic Surgery, Kanagawa National Hospital, Hadano, Japan.

The patient was a 78-year-old man who had undergone left lung segmentectomy (S6) with lymph node dissection for lung adenocarcinoma. One year and 5 months later, lung partial resection was performed for the lung cancer recurrence and the hematemesis was noted on the next day of surgery. Upper gastrointestinal endoscopy revealed extensive black necrosis on the mucosa of the esophagus, which was diagnosed as acute necrotizing esophagitis. Read More

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February 2020

Ulcerative reflux esophagitis associated with Clostridium ventriculi following hiatoplasty - is antibiotic treatment necessary? A case report.

Z Gastroenterol 2020 May 11;58(5):456-460. Epub 2020 May 11.

Diagnostic and Research Institute of Pathology, Medical University of Graz, Graz, Austria.

Clostridium (C.) ventriculi (known as Sarcina ventriculi) is a ubiquitous gram-positive, anaerobic, acidophilic coccus found in patients with gastric motility disorders. The microorganisms can be identified histologically by their characteristic presentation in tetrads or packets of 8 in hematoxylin and eosin stains. Read More

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http://dx.doi.org/10.1055/a-1123-7984DOI Listing

[Analysis of endoscopic screening compliance and related factors among high risk population of upper gastrointestinal cancer in urban areas of Henan Province from 2013 to 2017].

Zhonghua Yu Fang Yi Xue Za Zhi 2020 May;54(5):523-528

Office for Cancer Control and Research, Henan Cancer Hospital/The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450008, China.

To study the compliance of endoscopic screening for high-risk population of upper gastrointestinal cancer and relevant factors in urban areas of Henan Province, 2013-2017. The study participants were from the Cancer Screening Program in Urban Henan Province, China. From October 2013 to October 2017, 43 423 residents, who were evaluated as high-risk population for upper gastrointestinal cancer, were recruited from Zhengzhou, Zhumadian and Anyang. Read More

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http://dx.doi.org/10.3760/cma.j.cn112150-20200304-00238DOI Listing

Role of esophageal manometry and 24-h pH testing in patients with refractory reflux symptoms.

Indian J Gastroenterol 2020 May 9. Epub 2020 May 9.

Department of Gastroenterology, Arihant Hospital and Research Centre, 283-A Gumasta Nagar, Indore, 452 009, India.

Background: A proportion of patients with gastroesophageal reflux disease (GERD) do not respond to proton pump inhibitor (PPI) therapy.

Aim Of The Study: To determine the findings on high-resolution esophageal manometry (HREM) and 24-h pH recording in patients with typical GERD symptoms, refractory to PPI treatment.

Methods: Retrospective analysis of prospectively maintained database of patients referred for HREM and 24-h pH recording was done. Read More

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http://dx.doi.org/10.1007/s12664-020-01032-zDOI Listing

Comment on: Esophagitis After Bariatric Surgery: Large Cross-sectional Assessment of an Endoscopic Database.

Obes Surg 2020 May 9. Epub 2020 May 9.

Division of Bariatric Surgery, Department of Surgery, Carolinas Medical Center, Charlotte, NC, USA.

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http://dx.doi.org/10.1007/s11695-020-04666-2DOI Listing