18,585 results match your criteria Esophagitis


Pravastatin Reverses Established Radiation-Induced Cutaneous and Subcutaneous Fibrosis in Patients with Head and Neck Cancer: Results of the Biology-Driven Phase Ii Clinical Trial Pravacur.

Int J Radiat Oncol Biol Phys 2019 Feb 15. Epub 2019 Feb 15.

Radiation Oncology Department, CHUV Lausanne, Switzerland.

Purpose: The "xxx" phase II trial (NCTxxx) assessed the efficacy of pravastatin as anti-fibrotic agent in patients with established cutaneous and subcutaneous radiation-induced fibrosis (RIF) after head and neck squamous cell carcinoma (HNSCC) radiotherapy and/or radio-chemotherapy.

Methods And Materials: The main inclusion criteria were: patients with HNSCC in remission, with grade ≥2 cutaneous and subcutaneous neck RIF (NCI-CTCAE v4.0); no current treatment with statins or fibrates. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2019.02.024DOI Listing
February 2019

Epithelial barrier repair and prevention of allergy.

J Clin Invest 2019 Feb 18. Epub 2019 Feb 18.

Division of Pediatric Allergy and Clinical Immunology, Department of Pediatrics, and.

Allergic diseases have in common a dysfunctional epithelial barrier, which allows the penetration of allergens and microbes, leading to the release of type 2 cytokines that drive allergic inflammation. The accessibility of skin, compared with lung or gastrointestinal tissue, has facilitated detailed investigations into mechanisms underlying epithelial barrier dysfunction in atopic dermatitis (AD). This Review describes the formation of the skin barrier and analyzes the link between altered skin barrier formation and the pathogenesis of AD. Read More

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http://dx.doi.org/10.1172/JCI124608DOI Listing
February 2019

Risk factors and clinical characteristics of Pneumocystis jirovecii pneumonia in lung cancer.

Sci Rep 2019 Feb 14;9(1):2094. Epub 2019 Feb 14.

Division of Pulmonology, Department of Internal Medicine, Institute of Chest Diseases, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

Solid malignancies are associated with the development of Pneumocystis jirovecii pneumonia (PJP). This study aimed to evaluate the risk factors for PJP among patients with lung cancer. This retrospective case-control study compared patients who had lung cancer with PJP (n = 112) or without PJP (n = 336) matched according to age, sex, histopathology, and stage. Read More

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http://www.nature.com/articles/s41598-019-38618-3
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http://dx.doi.org/10.1038/s41598-019-38618-3DOI Listing
February 2019
1 Read

[Gastric Neuroendocrine Carcinoma(NEC)Treated with CDDP plus CPT-11 Chemotherapy].

Gan To Kagaku Ryoho 2019 Jan;46(1):65-69

Dept. of Digestive Surgery, Saku Central Hospital Advanced Care Center.

A 69-year-old man with chronic gastritis, reflux esophagitis, esophageal hiatal hernia, and history of appendicitis surgery complained of difficulty swallowing. Upper gastrointestinal endoscopy revealed a 10 cm sized Type 3 gastric cancer. Immunostaining was positive for chromogranin A(2+), synaptophysin(3+), CD56(-), and Ki-67>70%. Read More

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January 2019
2 Reads

Development of a Mucoadhesive and In Situ Gelling Formulation Based on κ-Carrageenan for Application on Oral Mucosa and Esophagus Walls. I. A Functional In Vitro Characterization.

Mar Drugs 2019 Feb 12;17(2). Epub 2019 Feb 12.

Department of Drug Sciences, University of Pavia, Viale Taramelli, 12 Pavia, Italy.

Oral mucositis and esophagitis represent the most frequent and clinically significant complications of cytoreductive chemotherapy and radiotherapy, which severely compromise the patient quality of life. The local application of polymeric gels could protect the injured tissues, alleviating the most painful symptoms. The present work aims at developing in situ gelling formulations for the treatment of oral mucositis and esophagitis. Read More

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http://dx.doi.org/10.3390/md17020112DOI Listing
February 2019

Assessing the Risk Factors for Refractory Eosinophilic Esophagitis in Children and Adults.

Gastroenterol Res Pract 2019 13;2019:1654543. Epub 2019 Jan 13.

Cardiac/Pulmonary Rehabilitation, ASST Pini/CTO, Milan, Italy.

Background: Up to one-third of the patients suffering from eosinophilic esophagitis (EoE) present a refractory form, as defined by nonresponsiveness in clinical, endoscopic, or histological assessment after first-line therapy. Several studies recently investigated which factors can influence the development of this disease, but very few analyzed the factors underlying refractory EoE.

Methods: Medical charts of patients affected by EoE were retrospectively evaluated. Read More

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https://www.hindawi.com/journals/grp/2019/1654543/
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http://dx.doi.org/10.1155/2019/1654543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348890PMC
January 2019
1 Read

Eosinophilic esophagitis and achalasia - just a coincidence?

Z Gastroenterol 2019 Feb 12;57(2):151-155. Epub 2019 Feb 12.

Medizinische Klinik II, HELIOS Klinikum Krefeld, Germany.

Background:  Eosinophilic esophagitis (EoE) is detected frequently in dysphagia and noncardiac chest pain. Management of patients with EoE may be complicated because EoE is associated frequently with esophageal motility disorders. We present the rare case of esophageal achalasia (EA) associated with eosinophilic infiltration and a literature review. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0808-5043
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http://dx.doi.org/10.1055/a-0808-5043DOI Listing
February 2019
1 Read

Plasma levels of TNF-α, IL-6, IFN-γ, IL-12, IL-17, IL-22, and IL-23 in achalasia, eosinophilic esophagitis (EoE), and gastroesophageal reflux disease (GERD).

BMC Gastroenterol 2019 Feb 11;19(1):28. Epub 2019 Feb 11.

University of South Florida, Division of Gastroenterology, Florida, USA.

An elevation of serum inflammatory biomarkers in achalasia patients compared with controls recently was demonstrated. It has not been determined whether the elevation of inflammatory cytokines is unique to achalasia or occurs with other diseases involving the esophagus. The primary aim of our study was to compare the differences in plasma immunological profiles (TNF- α receptor, IL-6, IFN-γ, IL-12, IL-17, IL-22, and IL-23) of patients with achalasia, eosinophilic esophagitis (EoE), and gastroesophageal reflux disease (GERD). Read More

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http://dx.doi.org/10.1186/s12876-019-0937-9DOI Listing
February 2019
1 Read

Interleukin-Mediated Pendrin Transcriptional Regulation in Airway and Esophageal Epithelia.

Int J Mol Sci 2019 Feb 9;20(3). Epub 2019 Feb 9.

Pharmgenetix GmbH, A-5081 Niederalm, Austria.

Pendrin (SLC26A4), a Cl/anion exchanger, is expressed at high levels in kidney, thyroid, and inner ear epithelia, where it has an essential role in bicarbonate secretion/chloride reabsorption, iodide accumulation, and endolymph ion balance, respectively. Pendrin is expressed at lower levels in other tissues, such as airways and esophageal epithelia, where it is transcriptionally regulated by the inflammatory cytokines interleukin (IL)-4 and IL-13 through a signal transducer and activator of transcription 6 (STAT6)-mediated pathway. In the airway epithelium, increased pendrin expression during inflammatory diseases leads to imbalances in airway surface liquid thickness and mucin release, while, in the esophageal epithelium, dysregulated pendrin expression is supposed to impact the intracellular pH regulation system. Read More

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http://dx.doi.org/10.3390/ijms20030731DOI Listing
February 2019
1 Read

Variations in the Clinical Course of Patients with Herpes Simplex Virus Esophagitis Based on Immunocompetence and Presence of Underlying Esophageal Disease.

Dig Dis Sci 2019 Feb 6. Epub 2019 Feb 6.

Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Background And Aims: Herpes simplex esophagitis (HSE) is the second most common cause of infectious esophagitis and occurs in both immunocompetent and immunocompromised patients. The aim of this study was to reappraise the clinical course of HSE in different patient populations based on degree of immunocompetence and the presence or absence of underlying esophageal disease.

Methods: Patients with histopathologically confirmed HSE identified from the Mayo Clinic pathology database from 2006 to 2016 were included in this study. Read More

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http://link.springer.com/10.1007/s10620-019-05493-x
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http://dx.doi.org/10.1007/s10620-019-05493-xDOI Listing
February 2019
3 Reads

Screening children for eosinophilic esophagitis: allergic and other risk factors.

Expert Rev Clin Immunol 2019 Feb 5. Epub 2019 Feb 5.

a Children's Hospital of Philadelphia , Division of Allergy & Immunology , Philadelphia , PA , USA.

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http://dx.doi.org/10.1080/1744666X.2019.1579643DOI Listing
February 2019

The role of oesophageal physiological testing in the assessment of noncardiac chest pain.

Ther Adv Chronic Dis 2018 11;9(12):257-267. Epub 2018 Sep 11.

GI Services, University College London Hospital, Ground floor west, 250 Euston Road, London, NW1 2 PG, London, UK.

Oesophageal physiology testing plays an important role in the diagnosis of noncardiac chest pain (NCCP) after cardiac, structural and mucosal abnormalities have been ruled out. Endoscopy can establish the presence of structural causes of chest pain such as cancer, oesophageal webs and diverticula. Even if macroscopically normal, eosinophilic oesophagitis is a common cause of chest pain and needs to be ruled out with an adequate biopsy regimen. Read More

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http://journals.sagepub.com/doi/10.1177/2040622318791392
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http://dx.doi.org/10.1177/2040622318791392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348533PMC
September 2018
7 Reads

Management of eosinophilic esophagitis is often discordant with guidelines and not patient-centered: results of a survey of gastroenterologists.

Dis Esophagus 2019 Jan 31. Epub 2019 Jan 31.

Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.

Published guidelines for the management of eosinophilic esophagitis (EoE) recommend an initial trial of proton pump inhibitors (PPI), histologic assessment for response to therapy, and tailoring treatments to patient needs and provider resources. Effectiveness studies directly comparing therapies are lacking, leaving a situation ripe for shared decision making. We aimed to assess gastroenterologists' adherence to guidelines and how they respond to EoE patients' preferences regarding management. Read More

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https://academic.oup.com/dote/advance-article/doi/10.1093/do
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http://dx.doi.org/10.1093/dote/doy133DOI Listing
January 2019
2 Reads

Food avoidance strategies in eosinophilic oesophagitis.

Clin Exp Allergy 2019 Feb 3. Epub 2019 Feb 3.

University of Pennsylvania School of Medicine, 34th Street and Civic Center Blvd, Philadelphia, United States.

EoE is a chronic disease associated with significant morbidity that can result in permanent fibrosis and stricture formation. Given the complexity a multidisciplinary approach is recommended to manage these patients. In the majority of children with EoE not responsive to proton pump inhibitors (PPI), inflammation is driven by sensitivity to foods and treatment with an elimination diet can be effective. Read More

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http://dx.doi.org/10.1111/cea.13360DOI Listing
February 2019
2 Reads

A Case of Desquamative Esophageal Lesions, Most Likely Due to Celecoxib.

Authors:
Yusaku Kajihara

Intern Med 2019 Feb 1. Epub 2019 Feb 1.

Department of Gastroenterology, Fuyoukai Murakami Hospital, Japan.

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http://dx.doi.org/10.2169/internalmedicine.2212-18DOI Listing
February 2019

A Comparative Analysis of Eating Behavior of School-Aged Children with Eosinophilic Esophagitis and Their Caregivers' Quality of Life: Perspectives of Caregivers.

Dysphagia 2019 Feb 2. Epub 2019 Feb 2.

Division of Pediatric Gastroenterology, Hepatology and Nutrition, Monroe Carell Jr. Children's Hospital at Vanderbilt University Medical Center, Doctors Office Tower, Suite 10226, 2200, Children's Way, Nashville, TN, 37232, USA.

Eosinophilic esophagitis (EoE) can affect eating behavior in infants and children and this may lead to stressful interactions with their caregivers and potentially impact their caregivers' quality of life. Clinical evaluation of eating behaviors can be time consuming and burdensome. Caregivers can provide a comprehensive assessment of their child's eating behavior; however, this has not been well studied in children with EoE. Read More

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http://dx.doi.org/10.1007/s00455-019-09984-xDOI Listing
February 2019
1 Read

Development and Validation of a Mucosal Impedance Contour Analysis System to Distinguish Esophageal Disorders.

Gastroenterology 2019 Jan 31. Epub 2019 Jan 31.

Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University Medical Center. Electronic address:

Background: Diagnostic testing for chronic esophageal disorders rely on histopathology analysis of biopsies or uncomfortable transnasal catheters or wireless pH monitoring, which capture abnormal intraluminal refluxate. We therefore developed a balloon mucosal impedance (MI) catheter system that instantly detects changes in esophageal mucosal integrity during endoscopy over a long segment of the esophagus. We performed a prospective study to evaluate the ability of a balloon-incorporated MI catheter to detect and evaluate esophageal disorders, including gastroesophageal reflux disease (GERD) and eosinophilic esophagitis (EoE). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00165085193035
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http://dx.doi.org/10.1053/j.gastro.2019.01.253DOI Listing
January 2019
4 Reads

A conceptual approach to understanding treatment response in eosinophilic esophagitis.

Clin Gastroenterol Hepatol 2019 Jan 30. Epub 2019 Jan 30.

Division of Pediatric Gastroenterology, University of Illinois College of Medicine, Peoria, IL.

While the diagnosis and initial treatment of eosinophilic esophagitis (EoE) are becoming more standardized, there are still major gaps in knowledge related to measuring treatment response. One such question centers on how to measure treatment response and what treatment end-points should be. This impacts not only patient care and engagement in decision-making, but also the field of drug development. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15423565193007
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http://dx.doi.org/10.1016/j.cgh.2019.01.030DOI Listing
January 2019
2 Reads

Transnasal Endoscopy in Unsedated Children With Eosinophilic Esophagitis Using Virtual Reality Video Goggles.

Clin Gastroenterol Hepatol 2019 Jan 29. Epub 2019 Jan 29.

Digestive Health Institute, Children's Hospital Colorado, Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado School of Medicine; Aerodigestive Program, Children's Hospital Colorado.

Background & Aims: Evaluation and treatment of children with eosinophilic esophagitis (EoE) requires serial endoscopic, visual, and histologic assessment by sedated esophagogastroduodenoscopy (EGD). Unsedated transnasal endoscopy (TNE) was reported to be successful in a pilot study of children. We evaluated video goggle and virtual reality-based unsedated TNE in children with EoE, collecting data on rates of completion, adverse events, and adequacy of visual and histologic findings. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15423565193007
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http://dx.doi.org/10.1016/j.cgh.2019.01.023DOI Listing
January 2019
1 Read

New Developments in the Diagnosis and Treatment of Eosinophilic Esophagitis.

Curr Treat Options Gastroenterol 2019 Feb 1. Epub 2019 Feb 1.

Division of Gastroenterology & Hepatology, Scripps Clinic, 10666 N. Torrey Pines Road, Suite 203N, La Jolla, CA, 92037, USA.

Purpose Of Review: Eosinophilic esophagitis (EoE) is a chronic, allergen-driven, immune-mediated disease of the esophagus that progresses to esophageal fibrostenosis if left untreated. The aim of this review is to provide a concise update on recent clinically relevant advances in the development of diagnostic and therapeutic approaches for EoE.

Recent Findings: Current diagnostic and disease monitoring protocols for EoE rely on repetitive endoscopic evaluations and esophageal tissue acquisition for histopathologic analysis. Read More

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http://link.springer.com/10.1007/s11938-019-00216-7
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http://dx.doi.org/10.1007/s11938-019-00216-7DOI Listing
February 2019
3 Reads

Fatty liver disease and the risk of erosive oesophagitis in the Korean population: a cross-sectional study.

BMJ Open 2019 Jan 30;9(1):e023585. Epub 2019 Jan 30.

Division of Gastroenterology, Department of Internal Medicine, Catholic Kwandong University International St. Mary's Hospital, Incheon, Korea.

Objectives: To investigate an association between fatty liver disease (FLD) and erosive oesophagitis.

Design And Setting: This was a cross-sectional study of subjects selected from examinees who underwent health check-up, including oesophagogastroduodenoscopy in one hospital between 2004 and 2011. Erosive oesophagitis was classified according to the Los Angeles classification and FLD was diagnosed with ultrasonography. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023585DOI Listing
January 2019
1 Read

[Clinical study on two reconstruction methods of proximal gastrectomy and piggyback jejunal interposition for Siewert Ⅱ or Ⅲ adenocarcinoma of esophagogastric junction].

Zhonghua Wai Ke Za Zhi 2019 Feb;57(2):114-118

Department of Digestive Minimally Invasive Surgery, Shanxi Provincial Cancer Hospital, Taiyuan 030013, China Zong Liang is working on the Department of Gastrointestinal Surgery, Northern Jiangsu People's Hospital, Yangzhou 225001, China.

To evaluate the clinical efficacy of two different digestive tract reconstruction methods in the Siewert Ⅱ or Ⅲ adenocarcinoma of esophagogastric junction underwent proximal gastrectomy and piggyback jejunal interposition. A total of 84 patients with Siewert Ⅱ or Ⅲ AEG who underwent proximal gastrectomy and interposition jejunal anastomosis were enrolled prospectively according to the exclusion criteria, from October 2015 to August 2017 at Department of Digestive Minimally Invasive Surgery, Shanxi Cancer Hospital. There were 61 male and 23 female patients, aged 48-69 years with an average age of 59. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5815.2019.02.008DOI Listing
February 2019
1 Read

[Application of intracorporeal uncut Roux-en-Y anastomosis in digestive tract reconstruction after laparoscopic total gastrectomy].

Zhonghua Wei Chang Wai Ke Za Zhi 2019 Jan;22(1):43-48

Department of Oncology Surgery, Fujian Provincial Hospital, Fuzhou 350001,

Objective: To explore the safety, feasibility and short-term efficacy of intracavitary uncut Roux-en-Y (URY) anastomosis in digestive tract reconstruction following laparoscopic total gastrectomy (LTG).

Methods: From November 2015 to January 2018, 67 gastric cancer patients underwent intracavitary URY following LTG to reconstruct the digestive tract at Oncological Surgery Department of Fujian Provincial Hospital. There were 41 males and 26 females with age of 50 to 81 (61. Read More

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January 2019
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Multicenter retrospective study to evaluate the efficacy and safety of the double-flap technique as antireflux esophagogastrostomy after proximal gastrectomy (rD-FLAP Study).

Ann Gastroenterol Surg 2019 Jan 11;3(1):96-103. Epub 2018 Oct 11.

Department of Gastroenterological Surgery Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan.

Aim: As a result of the difficulty in effective prevention of gastroesophageal reflux, no standard reconstruction procedure after proximal gastrectomy (PG) has yet been established. The double-flap technique (DFT), or Kamikawa procedure, is an antireflux reconstruction procedure in esophagogastrostomy. The efficacy of DFT has recently been reported in several studies. Read More

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http://dx.doi.org/10.1002/ags3.12216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345660PMC
January 2019
1 Read

[Postprandial Abdominal Fullness after Pylorus-Preserving Gastrectomy for Early Gastric Cancer].

Gan To Kagaku Ryoho 2018 Dec;45(13):2138-2140

Dept. of Surgery, The Nippon Dental University, School of Life Dentistry.

To clarify the basis for postprandial abdominal fullness(PAF)in patients after pylorus-preserving gastrectomy(PPG), the authors investigated the relationship of PAF with postgastrectomy disorder(PGD)and gastric emptying function(GEF)in PPG patients. A total of 22 patients(14 men and 8 women, average age 64.8 years)were divided into 2 groups[Group A, PAF-positive(n=12); Group B, PAF-negative(n=10)]at 1 year after PPG for early gastric cancer. Read More

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December 2018
9 Reads

Triangulating stapling vs functional end-to-end stapling for cervical esophagogastric anastomosis after esophagectomy for thoracic esophageal cancer: study protocol for a randomized controlled trial.

Trials 2019 Jan 28;20(1):83. Epub 2019 Jan 28.

Second Department of Surgery, School of Medicine, Wakayama Medical University, 811-1, Kimiidera, Wakayama, 641-8510, Japan.

Background: Several studies have reported that the triangulating stapling method decreases the incidence of anastomotic stricture after esophagectomy. Our previous randomized controlled trial, however, could not confirm the superiority of the triangulating stapling (TS) method over the circular stapling (CS) method in terms of postoperative anastomotic stricture rate. Recently, the functional end-to-end stapling (FEES) method for cervical anastomosis after esophagectomy was developed, and lower anastomotic stricture rates with FEES have been reported than for our previously experienced anastomotic methods. Read More

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http://dx.doi.org/10.1186/s13063-019-3201-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350379PMC
January 2019
1 Read

Plasma Urea Cycle Metabolites May Be Useful Biomarkers in Children With Eosinophilic Esophagitis.

Front Pediatr 2018 10;6:423. Epub 2019 Jan 10.

Department of Pediatric Gastroenterology, University of Texas McGovern Medical School, Houston, TX, United States.

Eosinophilic esophagitis (EoE) is a disorder of the esophagus that has become increasingly recognized in children. Because these children undergo multiple endoscopies, discovering a non-invasive biomarker of disease activity is highly desirable. The aim of this study was to use targeted plasma metabolomics to identify potential biomarker candidates for EoE in a discovery phase. Read More

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http://dx.doi.org/10.3389/fped.2018.00423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335364PMC
January 2019

New IgE Immediate Hypersensitivity Reactions Upon Reintroduction of Food Restricted for Treatment of Eosinophilic Esophagitis.

Ann Allergy Asthma Immunol 2019 Jan 23. Epub 2019 Jan 23.

Department of Gastroenterology, University of North Carolina School of Medicine, Chapel Hill, NC.

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http://dx.doi.org/10.1016/j.anai.2019.01.010DOI Listing
January 2019
1 Read

An Operable, Portable, and Disposable Ultrathin Endoscope for Evaluation of the Upper Gastrointestinal Tract.

Dig Dis Sci 2019 Jan 25. Epub 2019 Jan 25.

Catholic Photomedicine Research Institute, Seoul St. Mary's Hospital, The Catholic University of Korea, 505, Banpo-dong, Seocho-gu, Seoul, 137-070, Korea.

Background And Aims: A prototype of a disposable endoscope (DE) with easy viewing of the esophagus has been developed. The aim of this study was to develop a new version of DE with improved functionality and to assess the feasibility of DE as a screening tool for upper gastrointestinal diseases compared with conventional endoscopes.

Methods: Diagnostic accuracy and maneuverability of DE were evaluated by comparing endoscopy using DE with conventional endoscopy. Read More

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http://dx.doi.org/10.1007/s10620-019-5478-0DOI Listing
January 2019
2 Reads

Refractory Severe Esophagitis During Durvalumab Therapy in a Patient With Locally Advanced NSCLC.

J Thorac Oncol 2019 Feb;14(2):e40-e42

Department of Respiratory Medicine, Japan Community Health Care Organization Kyushu Hospital, Fukuoka, Japan.

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http://dx.doi.org/10.1016/j.jtho.2018.10.153DOI Listing
February 2019

The Role of MIF on Eosinophil Biology and Eosinophilic Inflammation.

Clin Rev Allergy Immunol 2019 Jan 25. Epub 2019 Jan 25.

Laboratório de Bacteriologia e Imunologia Clínica, Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

Macrophage migration inhibitory factor (MIF) is an inflammatory cytokine that participates in innate and adaptive immune responses. MIF contributes to the resistance against infection agents, but also to the cellular and tissue damage in infectious, autoimmune, and allergic diseases. In the past years, several studies demonstrated a critical role for MIF in the pathogenesis of type-2-mediated inflammation, including allergy and helminth infection. Read More

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http://dx.doi.org/10.1007/s12016-019-08726-zDOI Listing
January 2019
1 Read

No Maintenance, No Gain in Long-term Treatment of Eosinophilic Esophagitis.

Authors:
Evan S Dellon

Clin Gastroenterol Hepatol 2019 Feb;17(3):397-399

Center for Esophageal Diseases and Swallowing, Center for Gastrointestinal Biology and Disease, Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1016/j.cgh.2018.07.038DOI Listing
February 2019

Dabigatran-Induced Esophagitis Associated With Vomiting.

Am J Gastroenterol 2019 Jan 18. Epub 2019 Jan 18.

Division of Gastroenterology, Shinko Hospital, Hyogo, Japan.

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http://dx.doi.org/10.14309/ajg.0000000000000071DOI Listing
January 2019
1 Read

Black Esophagus (Acute Necrotizing Esophagitis) and Wischnewsky Lesions in a Death From Diabetic Ketoacidosis: A Possible Underlying Mechanism.

Am J Forensic Med Pathol 2019 Jan 23. Epub 2019 Jan 23.

Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

Acute esophageal necrosis (AEN), also known as black esophagus, is a rare clinical entity. It is recently described to be associated with diabetic ketoacidosis (DKA) in a few case reports. Wischnewsky lesions (WLs) are a classic postmortem finding seen in fatal hypothermia but are recently described to be associated with DKA. Read More

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http://dx.doi.org/10.1097/PAF.0000000000000463DOI Listing
January 2019
2 Reads

Outcome of peroral endoscopic myotomy in children with achalasia.

Surg Endosc 2019 Jan 22. Epub 2019 Jan 22.

Asian Institute of Gastroenterology, 6-3-661, Somajiguda, Hyderabad, 500 082, India.

Background And Aims: Achalasia cardia is rare in children and optimum endoscopic management options are not well known. Peroral endoscopic myotomy (POEM) is a novel treatment modality for achalasia with excellent results in adult patients. The long-term outcomes of POEM are not well known in children. Read More

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http://link.springer.com/10.1007/s00464-018-06654-1
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http://dx.doi.org/10.1007/s00464-018-06654-1DOI Listing
January 2019
7 Reads

Association of ten gastrointestinal and other medical conditions with positivity to faecal occult blood testing in routine screening: a large prospective study of women in England.

Int J Epidemiol 2019 Jan 21. Epub 2019 Jan 21.

Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.

Background: In 2006, the Bowel Cancer Screening Programme (BCSP) in England began offering biennial faecal occult blood testing (FOBt) at ages 60-69 years. Although FOBt is aimed at detecting colorectal neoplasms, other conditions can affect the result. In a large UK prospective study, we examined associations, both before and after screening, between FOBt positivity and 10 conditions that are often associated with gastrointestinal bleeding. Read More

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http://dx.doi.org/10.1093/ije/dyy271DOI Listing
January 2019
2 Reads

Systematic Endoscopy 5 Years After Sleeve Gastrectomy Results in a High Rate of Barrett's Esophagus: Results of a Multicenter Study.

Obes Surg 2019 Jan 21. Epub 2019 Jan 21.

Université Côte d'Azur, Nice, France.

Background: Recent evidence has indicated an increased risk of Barrett's esophagus (BE) in the long term after sleeve gastrectomy (SG).

Aim: The aim of the study is to investigate the spectrum of gastroesophageal reflux disease (GERD) symptoms as well as the prevalence of BE, at minimum 5 years after SG in patients who underwent SG in different bariatric centers of two countries: France and Italy.

Patients And Methods: Five high volume outpatient centers dedicated to bariatric surgery that routinely perform upper GI endoscopy before any bariatric procedures were invited to participate in the study. Read More

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http://dx.doi.org/10.1007/s11695-019-03704-yDOI Listing
January 2019
4 Reads

Effects of Abdominal Visceral Fat Change on Regression of Erosive Esophagitis.

Authors:
Ji Yong Ahn

Gut Liver 2019 01;13(1):1-2

Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.5009/gnl18299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347006PMC
January 2019
1 Read

The Optimal Chinese Herbal Injections for Use With Radiotherapy to Treat Esophageal Cancer: A Systematic Review and Bayesian Network Meta-Analysis.

Front Pharmacol 2018 4;9:1470. Epub 2019 Jan 4.

Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.

Esophageal cancer is one of the most common human cancers, and its incidence is highly endemic in China. The combination of Chinese herbal injections (CHIs) and radiotherapy should be informed by the best available evidence. To update and expand on previous work in order to compare and rank the efficacy and safety of CHIs in combination with radiotherapy to treat esophageal cancer. Read More

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http://dx.doi.org/10.3389/fphar.2018.01470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329258PMC
January 2019

Association Between Helicobacter pylori Exposure and Decreased Odds of Eosinophilic Esophagitis-a Systematic Review and Meta-analysis.

Clin Gastroenterol Hepatol 2019 Jan 16. Epub 2019 Jan 16.

Division of Gastroenterology, Department of Medicine and Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton Ontario Canada.

Background & Aims: Previous or current infection with Helicobacter pylori (exposure) has been reported to protect against eosinophilic esophagitis (EoE), perhaps due to H pylori-induced immunomodulation. However, findings vary. We performed a systematic review and meta-analysis of comparative studies to more clearly define the association between H pylori exposure and EoE. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.01.013DOI Listing
January 2019
5 Reads

A 12-Week Maintenance Therapy with a New Prepared Viscous Budesonide in Pediatric Eosinophilic Esophagitis.

Dig Dis Sci 2019 Jan 19. Epub 2019 Jan 19.

Department of Pediatrics, Pediatric Gastroenterology and Liver Unit, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy.

Background: A new prepared oral viscous budesonide (PVB) has been effective in inducing clinical and histological remission in pediatric eosinophilic esophagitis (EoE).

Aims: To evaluate the efficacy of a 12-week maintenance therapy on clinical, endoscopic, and histological remission using half of the dose used in the induction therapy.

Methods: We prospectively enrolled pediatric patients with active EoE. Read More

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http://link.springer.com/10.1007/s10620-018-5449-x
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http://dx.doi.org/10.1007/s10620-018-5449-xDOI Listing
January 2019
5 Reads

Unusual manifestation of disseminated herpes simplex virus type 2 infection associated with pharyngotonsilitis, esophagitis, and hemophagocytic lymphohisitocytosis without genital involvement.

BMC Infect Dis 2019 Jan 17;19(1):65. Epub 2019 Jan 17.

Division of Rheumatology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, 3-18-22 Hon-komagome, Tokyo, 1138677, Bunkyo-ku, Japan.

Background: Herpes simplex virus (HSV) has various presentations, depending on the patient's immune status, age, and the route of transmission. In adults, HSV type 1 is found predominantly in the oral area, and HSV type 2 (HSV-2) is commonly found in the genital area. HSV-2 infection without genital lesions is uncommon. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-019-3721-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337778PMC
January 2019
5 Reads

Lymphocytic esophagitis updated.

Authors:
Carlos A Rubio

Ann N Y Acad Sci 2019 Jan 17. Epub 2019 Jan 17.

Gastrointestinal and Liver Research Laboratory, Karolinska Institute and University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1111/nyas.14001DOI Listing
January 2019
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A rare case report of fungal esophagitis combined with giant gastric ulcer in an immunocompetent patient.

Medicine (Baltimore) 2019 Jan;98(3):e14158

Department of Digestive Disease, The First People's Hospital of Changzhou, The Third Affiliated Hospital of Soochow University.

Rationale: Fungal infection of gastrointestinal (GI) tract is usually seen in immunocompromised patients, but can rarely occur in immunocompetent people in whom no permissive factor is present.

Patient Concerns: We describe a 68-year-old male immunocompetent patient presenting with simultaneous fungal esophagitis and giant gastric ulcer.

Diagnoses: Repeated endoscopic biopsies were taken from the giant gastric ulcer edge and base and histology demonstrated granulation tissue and pseudohyphal fungal forms. Read More

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http://dx.doi.org/10.1097/MD.0000000000014158DOI Listing
January 2019
5 Reads

Lymphocytic Esophagitis: Inflammatory Pattern of Candida Esophagitis in a Patient With Ulcerative Colitis.

Int J Surg Pathol 2019 Jan 16:1066896918824023. Epub 2019 Jan 16.

1 Hospital for Sick Children, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1177/1066896918824023DOI Listing
January 2019
1 Read
0.961 Impact Factor

Symptom-based patient-reported outcomes in adults with eosinophilic esophagitis: value for treatment monitoring and randomized controlled trial design.

Curr Opin Allergy Clin Immunol 2019 Jan 14. Epub 2019 Jan 14.

Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois/CHUV, University of Lausanne, Lausanne, Switzerland.

Purpose Of Review: In adults with eosinophilic esophagitis (EoE), a chronic, inflammatory immune-mediated condition of the esophagus, both inflammation and fibrosis are likely associated with symptom generation. Therefore, assessing symptom-based patient-reported outcomes (PROs), defined by US Food and Drug Administration as 'any report of the status of a patient's health condition that comes directly from the patients, without interpretation of the patient's response by a clinician or anyone else', is important in the context of trials and observational studies of emerging therapies.

Recent Findings: For purposes of treatment monitoring, lack of symptoms does not predict the absence of biologic inflammation; hence, endoscopy with esophageal biopsies should be performed to check for residual inflammation. Read More

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http://dx.doi.org/10.1097/ACI.0000000000000514DOI Listing
January 2019
6 Reads

Validation of the Korean Version of the Gastroesophageal Reflux Disease Questionnaire for the Diagnosis of Gastroesophageal Reflux Disease.

J Neurogastroenterol Motil 2019 Jan;25(1):91-99

Department of Internal Medicine, Hanyang University School of Medicine, Seoul, Korea.

Background/aims: The Gastroesophageal Reflux Disease Questionnaire (GerdQ) has been developed and validated as a tool for the diagnosis of gastroesophageal reflux disease (GERD) in patients with gastrointestinal symptoms. However, the GerdQ and the cutoff value for determining GERD has not been validated in Korea.

Methods: Patients with symptoms suggestive of GERD were consecutively recruited. Read More

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http://dx.doi.org/10.5056/jnm18133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326199PMC
January 2019
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Gender-specific Effect of Micronutrient on Non-erosive Reflux Disease and Erosive Esophagitis.

J Neurogastroenterol Motil 2019 Jan;25(1):82-90

Department of Internal Medicine, Center for Cancer Prevention & Detection, National Cancer Center, Goyang, Gyeonggi-do, Korea.

Background/aims: The effect of dietary micronutrients on non-erosive reflux disease (NERD) and reflux esophagitis is unclear. We aim to evaluate the gender-specific effect of micronutrient on erosive esophagitis and NERD.

Methods: A total of 11 690 participants underwent endoscopy and completed 3-day recordings for dietary intake and questionnaires for reflux symptoms from 2004 to 2008. Read More

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http://www.jnmjournal.org/journal/view.html?doi=10.5056/jnm1
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http://dx.doi.org/10.5056/jnm18114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326192PMC
January 2019
9 Reads

Eosinophilic Esophagitis (EoE) Following Bioenteric Intragastric Balloon (BIB) Insertion.

Acta Gastroenterol Belg 2018 Oct-Dec;81(4):538-539

Internal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt.

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January 2019