18,722 results match your criteria Esophagitis


Laparoscopic One Anastomosis Gastric Bypass Versus Laparoscopic One Anastomosis Gastric Bypass with Braun Anastomosis: What's Better?

J Laparoendosc Adv Surg Tech A 2019 Apr 23. Epub 2019 Apr 23.

Department of General and Oncological Surgery, Policlinico San Marco, Zingonia, Italy.

Although laparoscopic one anastomosis gastric bypass (LOAGB) is a promising bariatric procedure, a large number of surgeons have strong objections mainly because of risk of bile reflux, marginal ulceration, malnutrition, and long-term risk of gastric and esophageal cancer. Lateral enteroenterostomy placed distally to a gastrojejunal anastomosis shows efficacy in preventing bile reflux after gastric resection and gastrojejunal anastomosis, but at present its efficacy in a bariatric surgery context has not been evaluated. From January 2013 to December 2018, 100 patients have been admitted to our department to be treated by performing LOAGB. Read More

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http://dx.doi.org/10.1089/lap.2019.0218DOI Listing
April 2019
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Association of single nucleotide polymorphisms at HSPB1 rs7459185 and TGFB1 rs11466353 with radiation esophagitis in lung cancer.

Radiother Oncol 2019 Mar 27;135:161-169. Epub 2019 Mar 27.

Department of Radiation Oncology, University Hospital Virgen del Rocío, Seville, Spain; Instituto de Biomedicina de Sevilla (IBIS/HUVR/CSIC/Universidad de Sevilla), Seville, Spain. Electronic address:

Background And Purpose: Radiochemotherapy (RCT) success in lung cancer (LC) can be limited due to the onset of adverse effects in the adjacent normal tissue such as radiation-induced esophageal toxicity (RIET). Therefore, specific biomarkers to customize the RCT dose administration and esophageal toxicity prediction are necessary to improve treatment effectiveness.

Materials And Methods: 247 LC patients prospectively recruited between 2012 and 2016 from 3 institutions were genotyped for 7 SNPs along TGFB1 and HSPB1 genes seeking an association with RIET risk development. Read More

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http://dx.doi.org/10.1016/j.radonc.2019.03.005DOI Listing

Clinical outcomes after intensity-modulated proton therapy with concurrent chemotherapy for inoperable non-small cell lung cancer.

Radiother Oncol 2019 Apr 17;136:136-142. Epub 2019 Apr 17.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA. Electronic address:

Background & Purpose: We report disease control, survival, and toxicity in patients with advanced inoperable non-small cell lung cancer (NSCLC) receiving concurrent chemotherapy and intensity-modulated proton therapy (IMPT) at a single institution.

Material And Methods: All patients were treated with IMPT with concurrent chemotherapy. Endpoints assessed were local, regional, and distant control, disease-free survival (DFS), and overall survival (OS). Read More

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http://dx.doi.org/10.1016/j.radonc.2019.03.029DOI Listing

Esophageal dilation in eosinophilic esophagitis using a novel endoscopic device.

Dig Liver Dis 2019 Apr 20. Epub 2019 Apr 20.

Institute of Pathology Saarbrücken-Rastpfuhl, Saarbrücken, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.dld.2019.03.022DOI Listing

Gastroesophageal Reflux Disease and Eosinophilic Esophagitis.

Gastroenterol Hepatol (N Y) 2019 Feb;15(2):111-113

Chief, Division of Gastroenterology Co-Director, Center for Esophageal Diseases Baylor University Medical Center at Dallas Co-Director, Center for Esophageal Research Baylor Scott & White Research Institute Dallas, Texas.

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February 2019

Factors Associated to Abnormal Distal Esophageal Exposure to Acid and Esophagitis in Individuals Seeking Bariatric Surgery.

Surg Obes Relat Dis 2019 Feb 3. Epub 2019 Feb 3.

Postgraduate Program in Medicine: Surgical Sciences, Federal University of Rio Grande do Sul, 2400 Ramiro Barcelos Street, Porto Alegre, RS, Brazil.

Background: Gastroesophageal reflux disease (GERD) impacts choice and outcomes of bariatric surgery. However, GERD diagnosis based solely on symptoms yields inaccurate results.

Objective: To determine the factors associated with a positive 24h pH-monitoring (pH-test) or esophagitis in patients with severe obesity seeking bariatric surgery. Read More

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http://dx.doi.org/10.1016/j.soard.2019.01.031DOI Listing
February 2019

Cost-effective care in eosinophilic esophagitis.

Authors:
Evan S Dellon

Ann Allergy Asthma Immunol 2019 Apr 19. Epub 2019 Apr 19.

Center for Esophageal Diseases and Swallowing, and Center for Gastrointestinal Biology and Disease, Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill, NC. Electronic address:

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http://dx.doi.org/10.1016/j.anai.2019.04.010DOI Listing

Laparoscopic Heller Myotomy: A Fundoplication Is Necessary to Control Gastroesophageal Reflux.

J Laparoendosc Adv Surg Tech A 2019 Apr 19. Epub 2019 Apr 19.

1 Department of Surgery and University of North Carolina, Chapel Hill, North Carolina.

Achalasia is a rare esophageal motility disorder that causes progressive dysphagia and regurgitation. The aim of treatment for achalasia is to provide symptom relief by reducing esophageal outflow resistance by disrupting the muscles at the level of the esophagogastric junction to allow esophageal emptying by gravity. A review of the literature concerning laparoscopic treatment of esophageal achalasia. Read More

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http://dx.doi.org/10.1089/lap.2019.0155DOI Listing

Chronic Obstructive Pulmonary Disease and the Risk of Esophagitis, Barrett Esophagus, and Esophageal Adenocarcinoma: A Primary Care Case-Control Study.

J Clin Gastroenterol 2019 Apr 17. Epub 2019 Apr 17.

Sandwell General Hospital, West Bromwich, UK.

Background: Chronic gastroesophageal reflux predisposes to the development of esophageal adenocarcinoma (EAC). Asthma and medication to treat it are associated with gastroesophageal reflux and EAC. We studied subjects with chronic obstructive pulmonary disease (COPD) to examine the relationship between COPD and medication used to treat it, and the risk of reflux esophagitis, Barrett esophagus, and EAC. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001215DOI Listing

Gastric Mucormycosis in a Renal Transplant Patient Treated with Isavuconazole Monotherapy.

Case Rep Transplant 2019 17;2019:9839780. Epub 2019 Mar 17.

Department of Nephrology, Hypertension and Transplant Medicine, Augusta University Health, Augusta, GA, USA.

Gastrointestinal mucormycosis is a rare infection in solid organ transplant recipients. Our patient, a 79-year-old male, presented with severe dysphagia and odynophagia about 2 weeks after receiving a renal transplant. An upper gastrointestinal (UGI) endoscopy revealed esophagitis and gastric ulceration, the cultures from which grew Rhizopus species. Read More

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http://dx.doi.org/10.1155/2019/9839780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441519PMC

Correction to: Eosinophilic esophagitis.

Allergy Asthma Clin Immunol 2019 10;15:22. Epub 2019 Apr 10.

4Division of Allergy, Department of Pediatrics, IWK Health Centre, Dalhousie University, Halifax, NS Canada.

[This corrects the article DOI: 10.1186/s13223-018-0287-0.]. Read More

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http://dx.doi.org/10.1186/s13223-019-0336-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456987PMC

[18F]fludeoxyglucose PET/CT in small-cell lung cancer: Analysis of the CONVERT randomized controlled trial.

J Thorac Oncol 2019 Apr 16. Epub 2019 Apr 16.

Division of Cancer Sciences, University of Manchester, Manchester, UK; Department of Clinical Oncology, The Christie NHS Foundation Trust, Manchester, UK.

Introduction: We used phase-3 CONVERT trial data to investigate the impact of fludeoxyglucose (F-FDG) PET/CT in small-cell lung cancer (SCLC).

Methods: CONVERT randomized limited-stage SCLC patients to twice-daily (45Gy in 30-fractions) or once-daily (66Gy in 33-fractions) chemoradiotherapy. Patients were divided into 2 groups in this unplanned analysis: those staged with conventional imaging (contrast-enhanced thorax and abdomen CT and brain imaging with/without bone scintigraphy) and those staged with F-FDG PET/CT in addition. Read More

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http://dx.doi.org/10.1016/j.jtho.2019.03.023DOI Listing

Risks of substance uses, alcohol flush response, Helicobacter pylori infection and upper digestive tract diseases-An endoscopy cross-sectional study.

Kaohsiung J Med Sci 2019 Apr 18. Epub 2019 Apr 18.

Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.

This study examines the effects of environmental hazards, including tobacco, alcohol/alcohol flush response, areca nut, and Helicobacter pylori (H pylori) infection on upper digestive diseases. This is a multi-hospital-based endoscopy-survey cross-sectional study. Subjects were received upper endoscopies in outpatient clinics at four hospitals in Taiwan between 2008 and 2013. Read More

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http://dx.doi.org/10.1002/kjm2.12071DOI Listing

Eosinophilic gastrointestinal diseases - Pathogenesis, diagnosis, and treatment.

Allergol Int 2019 Apr 16. Epub 2019 Apr 16.

Department of Medicine, Steel Memorial Hirohata Hospital, Himeji, Japan.

Eosinophilic gastrointestinal diseases (EGIDs) are divided into eosinophilic esophagitis (EoE) and eosinophilic gastroenteritis (EGE), depending on the involved gastrointestinal tract, though both are considered to be chronic Th2-type allergic diseases caused by food or environmental allergens. In development of EoE, refluxed gastric acid may also have an important role. For diagnosis of EGIDs, the presence of symptoms possibly originating from the involved gastrointestinal tract and dense eosinophil infiltration are important factors. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13238930193003
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http://dx.doi.org/10.1016/j.alit.2019.03.003DOI Listing
April 2019
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An in silico planning study comparing doses and estimated risk of toxicity in 3D-CRT, IMRT and proton beam therapy of patients with thymic tumours.

Phys Med 2019 Apr 30;60:120-126. Epub 2019 Mar 30.

Department of Oncology, Södersjukhuset, Stockholm, Sweden; Department of Clinical Science and Education, Karolinska Institutet, Södersjukhuset, Stockholm, Sweden.

Purpose: To compare the dose distributions produced in patients (pts) treated for thymic tumours with spot-scanning proton beam therapy (PBT) implemented with single-field uniform dose (SFUD), intensity-modulated radiation therapy (IMRT) and three-dimensional conformal photon-beam based radiotherapy (3D-CRT).

Methods: Twelve pts, treated with 3D-CRT, were included. Alternative IMRT and SFUD plans were constructed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S11201797193007
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http://dx.doi.org/10.1016/j.ejmp.2019.03.028DOI Listing
April 2019
1 Read

KLF4 activates NFκB signaling and esophageal epithelial inflammation via the Rho-related GTP-binding protein RHOF.

PLoS One 2019 18;14(4):e0215746. Epub 2019 Apr 18.

Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, United States of America.

Understanding the regulatory mechanisms within esophageal epithelia is essential to gain insight into the pathogenesis of esophageal diseases, which are among the leading causes of morbidity and mortality throughout the world. The zinc-finger transcription factor Krüppel-like factor (KLF4) is implicated in a large number of cellular processes, such as proliferation, differentiation, and inflammation in esophageal epithelia. In murine esophageal epithelia, Klf4 overexpression causes chronic inflammation which is mediated by activation of NFκB signaling downstream of KLF4, and this esophageal inflammation produces epithelial hyperplasia and subsequent esophageal squamous cell cancer. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215746PLOS
April 2019
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Development and Application of a Functional Human Esophageal Mucosa Explant Platform to Eosinophilic Esophagitis.

Sci Rep 2019 Apr 17;9(1):6206. Epub 2019 Apr 17.

Division of Allergy & Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.

There is an increasing prevalence of esophageal diseases but intact human tissue platforms to study esophageal function, disease mechanisms, and the interactions between cell types in situ are lacking. To address this, we utilized full thickness human donor esophagi to create and validate the ex vivo function of mucosa and smooth muscle (n = 25). Explanted tissue was tested for contractile responses to carbachol and histamine. Read More

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http://dx.doi.org/10.1038/s41598-019-41147-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470157PMC
April 2019
1 Read

Predictors of Gastrin Elevation Following Proton Pump Inhibitor Therapy.

J Clin Gastroenterol 2019 Apr 15. Epub 2019 Apr 15.

Department of Internal Medicine, Division of Gastroenterology, Landspitali-The National University Hospital of Iceland.

Goals: The goal of this study was to elucidate the most important predictors for elevation of gastrin in patients on long-term PPI therapy through analysis of data from 2 published studies in Icelandic patients with erosive GERD.

Background: Gastrin elevation is a known but variable consequence of proton pump inhibitor (PPI) therapy. Concerns have been raised about the clinical importance of chronic PPI induced gastrin elevation. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001200DOI Listing
April 2019
1 Read

History of gastroesophageal reflux disease in patients with suspected coronary artery disease.

Heart Vessels 2019 Apr 16. Epub 2019 Apr 16.

Department of Cardiovascular Medicine, JR Hiroshima Hospital, 3-1-36 Futabanosato, Higashi-ku, Hiroshima, 732-0057, Japan.

It is well known that patients with gastroesophageal reflux disease (GERD) experience GERD-related chest pain, but little is known about the relationship between GERD and coronary artery disease (CAD). We evaluated medical history of GERD in patients with suspected CAD and its association with types of CAD. We enrolled 236 patients who underwent coronary angiography (CAG). Read More

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http://dx.doi.org/10.1007/s00380-019-01413-1DOI Listing
April 2019
1 Read

Crioztinib-associated corrosive esophagitis in a bedridden lung cancer patient.

Kaohsiung J Med Sci 2019 Apr 16. Epub 2019 Apr 16.

Department of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/kjm2.12068
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http://dx.doi.org/10.1002/kjm2.12068DOI Listing
April 2019
1 Read

Involvement of EP2 and EP4 Receptors in Eosinophilic Esophagitis: A Pilot Study.

Dig Dis Sci 2019 Apr 15. Epub 2019 Apr 15.

Otto Loewi Research Center, Divison of Pharmacology, Medical University of Graz, Universitätsplatz 4, 8010, Graz, Austria.

Background: The prostaglandin D receptor DP2 has been implicated in eosinophil infiltration and the development of eosinophilic esophagitis (EoE).

Aims And Methods: In this study, we investigated an involvement of PGE (EP1-EP4) and PGD (DP1) receptors in EoE by measuring their expression in peripheral blood eosinophils and esophageal mucosal biopsies of EoE patients and by performing migration and adhesion assays with eosinophils from healthy donors.

Results: Expression of EP2 and EP4, but not EP1 and EP3, was decreased in blood eosinophils of patients with EoE vs. Read More

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http://dx.doi.org/10.1007/s10620-019-05623-5DOI Listing

Comparison of Hemospray and Endoclot for the treatment of gastrointestinal bleeding.

World J Gastroenterol 2019 Apr;25(13):1592-1602

Ludwig Demling Endoscopy Center of Excellence, Division of Gastroenterology, Friedrich-Alexander-University, Erlangen 91054, Germany.

Background: Gastrointestinal (GI) bleeding is a common indication for endoscopy. For refractory cases, hemostatic powders (HP) represent "touch-free" agents.

Aim: To analyze short term (ST-within 72 h-) and long-term (LT-within 30 d-) success for achieving hemostasis with HP and to directly compare the two agents Hemospray (HS) and Endoclot (EC). Read More

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https://www.wjgnet.com/1007-9327/full/v25/i13/1592.htm
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http://dx.doi.org/10.3748/wjg.v25.i13.1592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452236PMC
April 2019
3 Reads

Slight advantages of nimotuzumab versus cetuximab plus concurrent chemoradiotherapy in locally advanced esophageal squamous cell carcinoma.

Cancer Biol Ther 2019 Apr 14:1-6. Epub 2019 Apr 14.

a Department of Radiation Oncology , Shandong Cancer Hospital Affiliated to Shandong University , Jinan , Shandong Province , China.

This study aimed to compare the efficacy of nimotuzumab (Nimo) versus cetuximab (C225) plus concurrent chemoradiotherapy (CCRT) in locally advanced esophageal squamous cell carcinoma (LA-ESCC). A total of 95 patients with LA-ESCC were retrospectively reviewed, including 65 in Nimo and 30 in C225. The results showed that the ORR in Nimo (61. Read More

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http://dx.doi.org/10.1080/15384047.2019.1598760DOI Listing
April 2019
1 Read

Occupational Allergic Respiratory Disease and Eosinophilic Esophagitis by Wheat Flour in a Baker.

Arch Bronconeumol 2019 Apr 11. Epub 2019 Apr 11.

Allergy Section, Hospital General Universitario, Ciudad Real, Spain.

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http://dx.doi.org/10.1016/j.arbres.2019.01.003DOI Listing

Esophageal diverticulosis associated with Barrett's esophagus and erosive esophagitis.

Endoscopy 2019 Apr 12. Epub 2019 Apr 12.

Section of Gastroenterology, VA Boston Healthcare System, Boston, Massachusetts, United States.

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http://dx.doi.org/10.1055/a-0875-3913DOI Listing

The Clinical Efficacy of a Pure Alginate Formulation (Lamina G) for Controlling Symptoms in Individuals with Reflux Symptoms: A Randomized Clinical Study.

Gut Liver 2019 Feb 27. Epub 2019 Feb 27.

Department of Internal Medicine, Gangnam Severance Hospital, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.

Background/aims: Bicarbonate-containing alginate formulations are reported to be effective for controlling reflux symptoms. However, the efficacy of Lamina G alginate without gas production has not been reported. The aim is to evaluate the efficacy of a non-bicarbonate alginate in individuals with reflux symptoms without reflux esophagitis. Read More

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http://dx.doi.org/10.5009/gnl18378DOI Listing
February 2019
1 Read

Another case of reflux esophagitis?

Gastroenterology 2019 Apr 6. Epub 2019 Apr 6.

Translational Gastroenterology Unit, John Radcliffe Hospital, Oxford, United Kingdom.

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http://dx.doi.org/10.1053/j.gastro.2019.03.060DOI Listing

Eosinophilic Esophagitis.

JAMA 2019 04;321(14):1418

Texas Tech University Health Sciences Center, Lubbock.

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http://dx.doi.org/10.1001/jama.2019.1992DOI Listing

Extra-pleural pneumonectomy in the era of image-guided intensity-modulated radiotherapy.

Radiol Med 2019 Apr 8. Epub 2019 Apr 8.

Department of Radiation Oncology, Azienda Ospedaliero Universitaria Careggi, University of Florence, Largo Brambilla, 3, 50134, Florence, Italy.

Purpose: To assess the outcome of malignant pleural mesothelioma patients treated with extra-pleural pneumonectomy (EPP) and adjuvant radiotherapy (RT), using the most advanced radiotherapeutic techniques, namely image-guided intensity-modulated RT (IG-IMRT).

Methods And Materials: Fifty-four patients were analyzed. Minimum radiation dose was 50 Gy (2 Gy/fr). Read More

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http://link.springer.com/10.1007/s11547-019-01030-y
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http://dx.doi.org/10.1007/s11547-019-01030-yDOI Listing
April 2019
4 Reads

Fatal necrotizing esophagitis in a patient with leukocytoclastic cutaneous vasculitis and ankylosing spondylitis.

Autops Case Rep 2019 Apr-Jun;9(2):e2018070. Epub 2019 Mar 22.

Universidade de São Paulo (USP), Hospital Universitário, Internal Medicine Division. São Paulo, SP, Brazil.

Esophageal infection by spp. is a common opportunistic entity in immunocompromised hosts; however, systemic fungal dissemination due to perforation or transmural necrosis, also known as necrotizing esophagitis (NCE), is rare. We report the case of a 61-year-old male patient with diagnosed ankylosing spondylitis, severe arteriosclerosis, and vasculitis under immunosuppressive therapy who presented NCE with fungal and bacterial septicemia diagnosed at autopsy. Read More

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http://www.autopsyandcasereports.org/article/doi/10.4322/acr
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http://dx.doi.org/10.4322/acr.2018.070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433139PMC
March 2019
3 Reads

Singling out Th2 cells in eosinophilic esophagitis.

J Clin Invest 2019 Apr 8;130. Epub 2019 Apr 8.

Eosinophilic esophagitis (EoE) is a recently described disease in which exposure to specific foods and allergens leads to type 2 inflammation, epithelial barrier dysfunction, and difficulty in swallowing. In the current issue of the JCI, Wen and colleagues investigate tissue T cell heterogeneity in patients with EoE using single-cell RNA sequencing (scRNA-seq). Esophageal epithelium from individuals with EoE convtained a prominent population of Th2 cells not seen in controls. Read More

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https://www.jci.org/articles/view/128479
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http://dx.doi.org/10.1172/JCI128479DOI Listing
April 2019
6 Reads

Single-cell RNA sequencing identifies inflammatory tissue T cells in eosinophilic esophagitis.

J Clin Invest 2019 Apr 8;130. Epub 2019 Apr 8.

Division of Allergy and Immunology.

T cell heterogeneity is highly relevant to allergic disorders. We resolved the heterogeneity of human tissue CD3+ T cells during allergic inflammation, focusing on a tissue-specific allergic disease, eosinophilic esophagitis (EoE). We investigated 1088 single T cells derived from patients with a spectrum of disease activity. Read More

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https://www.jci.org/articles/view/125917
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http://dx.doi.org/10.1172/JCI125917DOI Listing
April 2019
7 Reads

Esophageal IgE, IgG4, and mucosal eosinophilia in individuals with dysphagia.

Int Forum Allergy Rhinol 2019 Apr 5. Epub 2019 Apr 5.

Department of Otolaryngology-Head and Neck Surgery, Weill Cornell Medical College, New York, NY.

Background: Eosinophilic esophagitis (EoE) is an inflammatory disease of the esophagus, producing failure to thrive in infants and dysphagia with food impaction in older children and adults. Although most people with EoE manifest atopic/allergic disease, the specific allergens to which immunoglobulin E (IgE) is directed, if any, have not yet been characterized.

Methods: Mucosal brush biopsy (MBB) and solid tissue biopsy (STB) specimens were prospectively obtained from 25 individuals with dysphagia and suspicion of EoE. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/alr.22339
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http://dx.doi.org/10.1002/alr.22339DOI Listing
April 2019
6 Reads

Acute necrotizing esophagitis presenting with severe lactic acidosis and shock.

Proc (Bayl Univ Med Cent) 2018 Oct 28;31(4):457-459. Epub 2018 Sep 28.

Department of Internal Medicine, Texas Tech University Health Sciences CenterLubbockTexas.

Acute necrotizing esophagitis, also known as "black esophagus," is typically characterized by a circumferential, friable black mucosal surface and preferentially involves the distal esophagus. It predominantly affects elderly men and presents as an upper gastrointestinal bleed. We describe a 60-year-old man with an acute upper gastrointestinal bleed and sepsis and subsequently acute necrotizing esophagitis. Read More

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http://dx.doi.org/10.1080/08998280.2018.1488494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413971PMC
October 2018
2 Reads

Enhanced dermatologic toxicity following concurrent treatment with palbociclib and radiation therapy: A case report.

Rep Pract Oncol Radiother 2019 May-Jun;24(3):276-280. Epub 2019 Mar 20.

Department of Radiation Oncology, Houston Methodist Hospital, 6565 Fannin Street, Houston, TX 77030, USA.

Background: Cyclin-dependent kinase (CDK) 4/6 inhibitors represent a new class of targeted therapy options for the treatment of estrogen receptor-positive (ER+) human epidermal growth factor 2-negative (HER2-) metastatic breast cancer. There are currently no published prospective data on the safety of use of radiation treatment with palbociclib.

Case: We describe the case of a patient with metastatic breast cancer who received radiation treatment to a metastatic supraclavicular lymph node to planned 60 Gy in 30 fractions while on palbociclib, a selective inhibitor of CDK4/6. Read More

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http://dx.doi.org/10.1016/j.rpor.2019.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429548PMC
March 2019
1 Read

Intraoesophageal migration of Teflon pledgets used for hiatal hernia repair: a serious adverse event.

BMJ Case Rep 2019 Apr 3;12(4). Epub 2019 Apr 3.

Service de chirurgie générale, Département de chirurgie, Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Québec, Canada.

11 months following an elective paraoesophageal hernia repair, a female patient presents to the emergency department with severe dysphagia. A CT showed a distention of the distal oesophagus caused by a foreign body and dense material inside and outside the oesophagus wall. A gastroscopy confirmed the presence of a bezoar and secondary oesophagitis due to the intraoesophageal migration of Teflon pledgets. Read More

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http://dx.doi.org/10.1136/bcr-2018-224383DOI Listing
April 2019
2 Reads

Serum eosinophilic cationic protein is correlated with food impaction and endoscopic severity in eosinophilic esophagitis.

Authors:
Cem Cengiz

Turk J Gastroenterol 2019 Apr;30(4):345-349

Department of Gastroenterology, TOBB University of Economics and Technology School of Medicine, Ankara, Turkey.

Background/aims: The aim of the present study was to analyze the diagnostic accuracy of serum eosinophilic cationic protein (ECP) for eosinophilic esophagitis (EoE) and the correlation of ECP with clinical, histopathological, laboratory, and endoscopic features of EoE.

Materials And Methods: Fifteen patients with EoE and 14 healthy controls were included in the study. Demographic parameters were recorded. Read More

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http://dx.doi.org/10.5152/tjg.2019.18529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453650PMC

Comparison of Feature Selection Methods for Predicting RT-Induced Toxicity.

Stud Health Technol Inform 2019 ;258:253-254

Biomedical Informatics, Biomedical Engineering and Health Economics, Institute of Biomedicine of Seville, IBIS / Virgen del Rocío University Hospital / CSIC / University of Seville, Seville, Spain.

This work addresses a scoping review of Feature Selection (FS) methods applied to a Lung Cancer dataset to elucidate parameters' relevance when predicting radiotherapy (RT) induced toxicity. Subsetting-based and Ranking-based FS methods were implemented along with 4 advanced classifiers to predict the onset of RT-induced acute esophagitis, cough, pneumonitis and dyspnea. Their prediction performance was measured in terms of the AUC for each model to find the best FS. Read More

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January 2019
4 Reads

Can Proximal Gastrectomy with Double-Tract Reconstruction Replace Total Gastrectomy? A Propensity Score Matching Analysis.

J Gastrointest Surg 2019 Apr 1. Epub 2019 Apr 1.

Department of Surgery and Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Gyeongsangnam-do, 50612, Republic of Korea.

Background: This retrospective cohort study compared proximal gastrectomy (PG) with double-tract reconstruction (DTR) versus total gastrectomy (TG) with Roux-en-Y reconstruction in terms of clinical outcomes.

Methods: All consecutive patients with upper early gastric cancer (EGC) who underwent PG-DTR or TG in 2008-2016 were selected. TG patients who matched PG-DTR patients in age, sex, body mass index, clinical stage, and ASA score were selected by propensity score matching. Read More

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http://dx.doi.org/10.1007/s11605-019-04195-zDOI Listing
April 2019
2 Reads

"What do allergists in practice need to know about non-IgE-mediated food allergies".

Ann Allergy Asthma Immunol 2019 Mar 29. Epub 2019 Mar 29.

Division of Allergy and Immunology, Department of Pediatric, Children's Hospital of Philadelphia, Philadelphia, Pa; Perelman School of Medicine, The University of Pennsylvania, Philadelphia, Pa.

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http://dx.doi.org/10.1016/j.anai.2019.03.025DOI Listing
March 2019
1 Read

Clinical presentations, management, and outcomes of acute esophageal necrosis: a systemic review.

Expert Rev Gastroenterol Hepatol 2019 May 16;13(5):507-514. Epub 2019 Apr 16.

a Sanford School of Medicine , University of South Dakota , Sioux Falls , SD , USA.

Background: To review all the reported literature on acute esophageal necrosis.

Research Methods: Databases were searched using the special Medical Subject Heading (MeSH) terms. All the available reported cases of acute esophageal necrosis were analyzed. Read More

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http://dx.doi.org/10.1080/17474124.2019.1601555DOI Listing
May 2019
4 Reads

Association between endoscopic findings of eosinophilic esophagitis and responsiveness to proton pump inhibitors.

Endosc Int Open 2019 Apr 21;7(4):E433-E439. Epub 2019 Mar 21.

Department of Gastroenterology, Osaka City University Graduate School of Medicine.

 Endoscopic findings of esophageal eosinophilia sometimes localize to small areas of the esophagus. A previous study suggested that pathogenesis of localized-type eosinophilic esophagitis (LEoE) was associated with acid reflux. However, LEoE treatment outcomes have not been studied. Read More

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http://dx.doi.org/10.1055/a-0859-7276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428677PMC
April 2019
1 Read

Risk factors associated with oral manifestations and oral health impact of gastro-oesophageal reflux disease: a multicentre, cross-sectional study in Pakistan.

BMJ Open 2019 Mar 30;9(3):e021458. Epub 2019 Mar 30.

Department of Prosthodontics and Implantology, King Faisal University, Al-Hasa, Saudi Arabia.

Objective: Gastro-oesophageal reflux disease (GORD) is a relatively common disorder and manifests with extraoesophageal symptoms, such as dental erosions (DE), cough, laryngitis, asthma, and oral soft- and hard-tissue pathologies. This study aimed (1) to identify oral soft and hard-tissue changes in patients with GORD and (2) to evaluate these oral changes as indices for assessing GORD and its severity.

Setting: This cross-sectional study was conducted at four major tertiary care government hospitals, in two metropolitan cities of Pakistan. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2017-02145
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http://dx.doi.org/10.1136/bmjopen-2017-021458DOI Listing
March 2019
6 Reads
2.063 Impact Factor

Food Allergy, Eosinophilic Esophagitis and the Enigma of IgG4.

Ann Allergy Asthma Immunol 2019 Mar 27. Epub 2019 Mar 27.

University of Virginia School of Medicine, Division of Allergy and Clinical Immunology, Charlottesville, VA. Electronic address:

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http://dx.doi.org/10.1016/j.anai.2019.03.024DOI Listing
March 2019
2 Reads

Illuminating Elimination Diets: Controversies Regarding Dietary Treatment of Eosinophilic Esophagitis.

Dig Dis Sci 2019 Mar 29. Epub 2019 Mar 29.

Division of Gastroenterology and Hepatology, Center for Esophageal Diseases and Swallowing and Center for Gastrointestinal Biology and Disease, University of North Carolina School of Medicine, UNC-CH, CB#7080, Bioinformatics Building, 130 Mason Farm Rd., Chapel Hill, NC, 27599-7080, USA.

Eosinophilic esophagitis (EoE) is an immune-mediated disease triggered by food antigens for which dietary elimination treatment can induce and sustain histologic remission. Our review aims to describe the state of the art regarding dietary treatment of EoE, highlighting a number of areas of controversy related to dietary therapy in EoE, including novel modalities for determining food triggers, making the empiric dietary elimination process more efficient, issues of cross-contamination and "dosing" of how much food to avoid or add back, costs and effects on quality of life, long-term efficacy, and the risk of developing immediate IgE-type reactions after initial dietary elimination. Elemental formulas, empiric elimination diets, and targeted allergy test-directed elimination diets are well-described treatments for EoE. Read More

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http://dx.doi.org/10.1007/s10620-019-05602-wDOI Listing
March 2019
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Obesity and hiatal hernia may be non-allergic risk factors for esophageal eosinophilia in Japanese adults.

Esophagus 2019 Mar 29. Epub 2019 Mar 29.

Department of Gastroenterology, Graduate School of Medicine, Osaka City University, 1-4-3 Asahimachi, Abeno-ku, Osaka, 545-8585, Japan.

Background: Esophageal eosinophilia (EE) is a basal condition of eosinophilic esophageal disorders including eosinophilic esophagitis (EoE) and asymptomatic EE. EoE is considered as an allergic disorder, while it is unclear whether other non-allergic conditions are involved in the pathophysiology of EE. The aim of this study is to investigate the non-allergic risk factors for EE. Read More

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http://dx.doi.org/10.1007/s10388-019-00662-3DOI Listing
March 2019
2 Reads

Epidemiology and implications of concurrent diagnosis of eosinophilic oesophagitis and IBD based on a prospective population-based analysis.

Gut 2019 Mar 28. Epub 2019 Mar 28.

Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York City, New York, USA.

Objective: Eosinophilic oesophagitis (EoO) and IBD are immune-mediated diseases of the gastrointestinal tract with possible overlapping pathogenic mechanisms. Our aim was to define the epidemiology and clinical implications of concurrent EoO and IBD diagnoses.

Design: We conducted a prospective cohort analysis using the Truven MarketScan database (2009-2016) to estimate the incidence and prevalence of EoO in patients with Crohn's disease (CD) or UC and vice versa. Read More

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http://dx.doi.org/10.1136/gutjnl-2018-318074DOI Listing
March 2019
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Efficacy of Budesonide Orodispersible Tablets as Induction Therapy for Eosinophilic Esophagitis in a Randomized Placebo-controlled Trial.

Gastroenterology 2019 Mar 25. Epub 2019 Mar 25.

Swiss EoE Research Group, Olten, Switzerland.

Background & Aims: Swallowed topical-acting corticosteroids are recommended as first-line therapy for eosinophilic esophagitis (EoE). Asthma medications not optimized for esophageal delivery are sometimes effective, although given off label. We performed a randomized, placebo-controlled trial to assess the effectiveness and tolerability of a budesonide orodispersible tablet (BOT) that allows the drug to be delivered to the esophagus in adults with active EoE. Read More

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http://dx.doi.org/10.1053/j.gastro.2019.03.025DOI Listing
March 2019
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Feeding Difficulties in Children with non-IgE mediated Food Allergic Gastrointestinal Disorders.

Ann Allergy Asthma Immunol 2019 Mar 25. Epub 2019 Mar 25.

The Ellyn Satter Institute, Madison, Wisconsin, USA.

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http://dx.doi.org/10.1016/j.anai.2019.03.020DOI Listing