21,143 results match your criteria Esophagitis

Accurate and timely diagnosis of Eosinophilic Esophagitis improves over time in Europe. An analysis of the EoE CONNECT Registry.

United European Gastroenterol J 2022 May 16. Epub 2022 May 16.

Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas, Madrid, Spain.

Background: Poor adherence to clinical practice guidelines for eosinophilic esophagitis (EoE) has been described and the diagnostic delay of the disease continues to be unacceptable in many settings.

Objective: To analyze the impact of improved knowledge provided by the successive international clinical practice guidelines on reducing diagnostic delay and improving the diagnostic process for European patients with EoE.

Methods: Cross-sectional analysis of the EoE CONNECT registry based on clinical practice. Read More

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Cost-effectiveness analysis of vonoprazan versus proton pump inhibitors in the treatment of reflux esophagitis in China.

Ann Transl Med 2022 Apr;10(8):480

Medical Decision and Economic Group, Department of Pharmacy, Ren Ji Hospital, South Campus, School of Medicine, Shanghai Jiaotong University, Shanghai, China.

Background: Proton pump inhibitors (PPIs) have been recommended as standard of care for reflux esophagitis (RE). Vonoprazan (VPZ), a novel potassium-competitive acid blocker (P-CAB), has been approved in China after demonstrating clinical benefit in RE. However, there are not any published literature reported the cost-effectiveness of VPZ compared with PPI in Chinese healthcare setting. Read More

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Comparison of changes in body fat mass and reflux esophagitis between reconstruction methods after proximal gastrectomy.

Asian J Surg 2022 May 12. Epub 2022 May 12.

Department of Surgery, Keio University School of Medicine, Tokyo, Japan.

Background: Although proximal gastrectomy (PG) is a function-preserving surgical option, it remains unclear as to which reconstruction method can prevent reflux and maintain body composition.

Methods: Patients who underwent PG at Keio University between April 2011 and November 2018 were analyzed. Changes in the subcutaneous and visceral adipose tissues were comparatively assessed before and after a year of surgery for three common reconstruction methods. Read More

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Application of Convolutional Neural Networks for Diagnosis of Eosinophilic Esophagitis Based on Endoscopic Imaging.

J Clin Med 2022 Apr 30;11(9). Epub 2022 Apr 30.

AI Medical Service Inc., Toshima, Tokyo 170-0013, Japan.

Subjective symptoms associated with eosinophilic esophagitis (EoE), such as dysphagia, are not specific, thus the endoscopic identification of suggestive EoE findings is quite important for facilitating endoscopic biopsy sampling. However, poor inter-observer agreement among endoscopists regarding diagnosis has become a complicated issue, especially with inexperienced practitioners. Therefore, we constructed a computer-assisted diagnosis (CAD) system using a convolutional neural network (CNN) and evaluated its performance as a diagnostic utility. Read More

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Impact of the Tumor Microenvironment for Esophageal Tumor Development-An Opportunity for Prevention?

Cancers (Basel) 2022 Apr 30;14(9). Epub 2022 Apr 30.

Department of Internal Medicine II, University Medical Center Freiburg, 79106 Freiburg, Germany.

Despite therapeutical advancements, and in contrast to other malignancies, esophageal adenocarcinoma (EAC) prognosis remains dismal while the incidence has markedly increased worldwide over the past decades. EAC is a malignancy of the distal esophageal squamous epithelium at the squamocolumnar junction with gastric cells expanding into the esophagus. Most EAC patients have a history of Barret's esophagus (BE), a metaplastic adaption to chronic reflux, initially causing an inflammatory microenvironment. Read More

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Expression of VEGF, EGF, and Their Receptors in Squamous Esophageal Mucosa, with Correlations to Histological Findings and Endoscopic Minimal Changes, in Patients with Different GERD Phenotypes.

Int J Environ Res Public Health 2022 Apr 27;19(9). Epub 2022 Apr 27.

Department of Gastroenterology and Internal Medicine, Medical University of Bialystok, 15-276 Bialystok, Poland.

Background: Gastroesophageal reflux disease (GERD) may present as nonerosive reflux disease (NERD), erosive esophagitis (EE), or be complicated by Barrett's esophagus (BE). The explanation as to what determines the phenotype of GERD is awaited. Therefore, we assessed the correlation between the growth factors expression and endoscopic as histologic findings in GERD patients. Read More

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Safety and efficacy of pegylated recombinant human granulocyte colony-stimulating factor during concurrent chemoradiotherapy for small-cell lung cancer: a retrospective, cohort-controlled trial.

BMC Cancer 2022 May 13;22(1):542. Epub 2022 May 13.

Shandong First Medical University, Jinan, 250000, Shandong, China.

Objective: To investigate pegylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) safety and efficacy in preventing hematological toxicity during concurrent chemoradiotherapy (CCRT) for small-cell lung cancer (SCLC).

Methods: We retrospectively assessed 80 SCLC patients treated with CCRT from January 2013 to December 2018 who received PEG-rhG-CSF within 48 hours after the end of chemotherapy, defined as prophylactic use, as the experimental group. An additional 80 patients who were not treated with PEG-rhG-CSF were matched 1:1 by the propensity score matching method and served as the control group. Read More

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Successful treatment of hemorrhagic radiation esophagitis with radiofrequency ablation.

Endoscopy 2022 May 13. Epub 2022 May 13.

Department of Gastroenterology and Digestive Oncology, Cochin Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France.

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Clinical outcomes of definitive radiotherapy for patients with cT1aN0M0 esophageal cancer unsuitable for endoscopic resection and surgery.

J Gastrointest Oncol 2022 Apr;13(2):454-461

Department of Radiation Oncology, Juntendo University, Graduate School of Medicine, Tokyo, Japan.

Background: Studies on the clinical outcomes of radiotherapy for clinical (c)T1aN0M0 () esophageal cancer (EC) are limited. Therefore, this retrospective study aimed to clarify the clinical outcomes of definitive radiotherapy (RT) or chemoradiotherapy (CRT) for cT1aN0M0 EC unsuitable for endoscopic resection and surgery.

Methods: Patients with cT1aN0M0 esophageal squamous cell carcinoma who underwent definitive RT or CRT between January 2009 and December 2020 were retrospectively reviewed. Read More

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Gastric Pull-up: A Back-up Surgical Solution in the Treatment of Large Hiatal Hernias.

Chirurgia (Bucur) 2022 Apr;117(eCollection):1-6

The laparoscopic treatment of the hiatal hernias is nowadays the standard procedure. However, due to the volume and the age of the affliction, there are some situations in which the classical approach is indicated. The latter is associated with specific risks. Read More

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Analysis of Esophageal Motility and Reflux Characteristics in Patients with Gastroesophageal Reflux Disease With or Without Extraesophageal Symptoms.

Turk J Gastroenterol 2022 Apr;33(4):280-285

Department of Digestion, Zhejiang Hospital, Hangzhou, China.

Background: The pathogenesis of extraesophageal symptoms of gastroesophageal reflux disease is complex, and esophageal motility and reflux may be involved in it. In this study, we aimed to compare esophageal motility and reflux characteristics in gastroesopha- geal reflux disease patients with and without extraesophageal symptoms by high-resolution manometry and multichannel intraluminal impedance-pH monitoring.

Methods: We retrospectively studied gastroesophageal reflux disease patients between January 2014 and December 2018. Read More

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Non-oesophageal eosinophilic gastrointestinal diseases are undersuspected clinically and underdiagnosed pathologically.

Aliment Pharmacol Ther 2022 May 12. Epub 2022 May 12.

Inform Diagnostics, Irving, Texas, USA.

Background: Non-oesophageal gastrointestinal eosinophilic diseases (EGID) are considered rare. However, low disease awareness among clinicians and pathologists may contribute to underdiagnosis.

Aims: To determine how frequently requests to evaluate for EGID accompany gastrointestinal biopsies and in what proportion of suspected cases pathologists address these requests, either confirming or refuting the clinical suspicion. Read More

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The Inclusion of Voice Assessments to Aid Diagnostic and Surgical Decision Making for Patients With Laryngopharyngeal Reflux.

J Voice 2022 May 7. Epub 2022 May 7.

Division of General Surgery, Department of Surgery, University of Louisville, School of Medicine, Louisville, Kentucky.

Objective: Patients with suspected laryngopharyngeal reflux (LPR) present with a variety of symptoms, such as cough, hoarseness, and globus sensation, and often do not have the classic features associated with gastroesophageal reflux disease.

Study Design: To achieve greater clarity in the symptom presentation, response to treatment, and the impact on vocal function among patients presenting with signs and symptoms consistent with LPR, we prospectively evaluated initial assessments and outcomes after medication or surgical management.

Methods: A sample of 109 patients completed self-report measures of reflux symptoms, voice handicap, and underwent diagnostic workup by both laryngologist and foregut surgeon to include laryngoscopy, esophagogastroduodenoscopy, manometry and pH monitoring. Read More

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Peroral Endoscopic Myotomy Is an Effective Treatment Option for Managing Jackhammer Esophagus: A Single Center Experience.

J Clin Gastroenterol 2022 Apr 28. Epub 2022 Apr 28.

Division of Gastroenterology & Hepatology, University of Maryland School of Medicine, University of Maryland Medical Center.

Background And Aims: Jackhammer esophagus (JE) is a rare hypercontractile motility disorder often associated with dysphagia, regurgitation, and chest pain. In patients with clinically relevant symptoms, treatment options aim to decrease esophageal contractions. Medical, endoscopic and surgical therapies have limited long-term efficacy. Read More

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Comparison of the Clinical Outcomes of Reconstruction Methods After Distal Gastrectomy: A Systematic Review and Meta-Analysis Based on Randomized Controlled Trials.

J Gastric Cancer 2022 Apr;22(2):83-93

Department of Surgery, Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon, Korea.

Background: To analyze the short- and long-term clinical outcomes of 2 reconstruction methods after distal gastrectomy for gastric cancer.

Methods: Three keywords, "gastric neoplasm," "distal gastrectomy," and "reconstruction," were used to search PubMed. We selected only randomized controlled trial that compared the anastomosis methods. Read More

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Long-term outcome of omalizumab-assisted desensitisation to cow's milk and eggs in patients refractory to conventional oral immunotherapy: real-life study.

Allergol Immunopathol (Madr) 2022 1;50(3):1-7. Epub 2022 May 1.

Paediatric Allergies, Immunology and Pneumology Unit, Paediatric Medicine Service, Parc Tauli Hospital Universitari. Institut d'Investigació i Innovació Parc Tauli (I3PT). Universitat Autònoma de Barcelona, Sabadell, Barcelona, Spain.

Background: Oral immunotherapy (OIT) is a promising approach to cow's milk and egg allergies, but reactions are frequent and some patients cannot be desensitized.

Objective: To evaluate long-term OIT outcomes with omalizumab (OMZ) in paediatric patients with severe egg and/or milk allergies.

Methods: This retrospective real-life study analysed findings in children with Immunoglobulin E-mediated allergy to cow's milk and/or hen eggs refractory to conventional OIT, who underwent OIT with OMZ in our department between 1 January 2010 and 31 December 2015. Read More

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Successful Resuscitation of Cardiac Arrest After Refeeding Syndrome Associated with Hiatal Hernia: A Case Report.

Am J Case Rep 2022 May 7;23:e935605. Epub 2022 May 7.

Department of Pharmacy, Okayama Saiseikai General Hospital, Okayama, Japan.

BACKGROUND Refeeding syndrome (RFS) is a life-threatening syndrome, which can cause sudden death. RFS has been reported frequently in young patients with anorexia without organic disease; however, there are few reports in elderly patients with organic disease. Herein, we report a case of cardiac arrest after refeeding syndrome associated with hiatal hernia. Read More

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Current and emerging therapies for eosinophilic esophagitis.

Allergy Asthma Proc 2022 05;43(3):178-186

Department of Medicine, Monmouth Medical Center, Rutgers Robert Wood Johnson Medical Center, Long Branch, New Jersey.

Eosinophilic esophagitis (EoE) is a Type-2 chronic inflammatory food antigen-driven disease of the esophagus, characterized by eosinophilic predominant inflammation and a constellation of symptoms. The incidence and prevalence of EoE has increased over the past 2 decades. There is an unmet need for approved less burdensome treatment options. Read More

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[Diagnosis of laryngopharyngeal Reflux by Impedance with esophageal pHmetry in children with chronic dysphonia].

Andes Pediatr 2021 Dec 8;92(6):847-853. Epub 2021 Sep 8.

Servicio de Otorrinolaringología, Hospital San Juan de Dios, Universidad de Chile, Santiago, Chile.

Introduction: Laryngopharyngeal Reflux (LPR) is the retrograde flow of gastric or duodenal contents into the pharynx and larynx, causing inflammation in the upper aerodigestive tract. Traditionally, a pH monitoring study with an acid reflux index was used. The use of multichannel intraluminal impedance testing with pH monitoring (MII-pH) confirms a causal relationship between suspicious symptoms and LPR. Read More

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December 2021

Physiological tracer distribution and benign lesion incidental uptake of Al18F-NOTA-FAPI-04 on PET/CT imaging.

Nucl Med Commun 2022 May 4. Epub 2022 May 4.

The PET/CT Center, Department of Nuclear Medicine, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, People's Republic of China.

Objective: To systematically investigate the physiological distribution and benign lesion incidental uptake of Al18F-NOTA-FAPI-04 (18F-FAPI) in cancer patients to establish the normal uptake range in relevant organs and lesions.

Methods: Twenty patients who underwent 18F-FAPI PET/CT imaging were retrospectively assessed. Organ and benign lesion tracer uptake was quantified based on standardized uptake values (SUVmax and SUVmean). Read More

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Update on Emerging Pharmacologic Therapies for Patients With Eosinophilic Esophagitis.

Gastroenterol Hepatol (N Y) 2022 Apr;18(4):207-212

Division of Gastroenterology and Nutrition, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.

Eosinophilic esophagitis (EoE) is a chronic immune-mediated condition identified by eosinophilic infiltration of the esophageal mucosa. Historically, pharmacologic options have been limited to proton pump inhibitors and swallowed topical corticosteroids, neither of which have been approved by the US Food and Drug Administration for the treatment of EoE. The goal of therapy is ultimately to avoid irreversible stricturing disease. Read More

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The efficacy and safety of keverprazan, a novel potassium-competitive acid blocker, in treating erosive oesophagitis: A phase III, randomised, double-blind multicentre study.

Aliment Pharmacol Ther 2022 May 3. Epub 2022 May 3.

Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

Background: Keverprazan is a novel potassium-competitive acid blocker (P-CAB) with a strong acid-suppressive capacity that may provide clinical benefit in acid-related diseases.

Aims: This study aimed to explore the non-inferior efficacy and safety of keverprazan to lansoprazole in treating erosive oesophagitis (EO).

Methods: This was a phase III, randomised, double-blind multicentre study. Read More

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Changes in impedance planimetry (EndoFLIP) measurements at follow-up after peroral endoscopic myotomy (POEM).

Surg Endosc 2022 May 3. Epub 2022 May 3.

Department of Surgery, NorthShore University Health System, 2650 Ridge Ave, GCSI Suite B665, Evanston, IL, 60201, USA.

Background: Numerous studies show changes in functional lumen imaging probe (FLIP) measurements after myotomy during peroral endoscopic myotomy (POEM), but few report on FLIP measurements at follow-up esophagogastroduodenoscopy (EGD). The purpose of this study was to compare perioperative FLIP measurements to those at follow-up EGD.

Methods: Patients who underwent POEM with FLIP in the operating room and POEM patients who had EGD with FLIP at follow-up were included. Read More

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Knowledge gaps in the management of refractory reflux-like symptoms: Healthcare provider survey.

Neurogastroenterol Motil 2022 May 3:e14387. Epub 2022 May 3.

Division of Gastroenterology and Hepatology, Veterans Affairs Medical Center, University of Kansas School of Medicine, Kansas City, Missouri, USA.

Background: Refractory reflux-like symptoms have a substantial impact on patients and healthcare providers. The aim of the survey was to qualitatively assess the needs and attitudes of practicing clinicians around the management of refractory reflux symptoms and refractory gastroesophageal reflux disease (rGERD).

Methods: An International Working Group for the Classification of Oesophagitis (IWGCO) steering committee invited clinicians to complete an online survey including 17 questions. Read More

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Clinical spectrum of paediatric and adult eosinophilic oesophagitis in the North East of England from 2016 to 2019.

Frontline Gastroenterol 2022 8;13(3):231-236. Epub 2021 Jun 8.

Gastroenterology, County Durham and Darlington NHS Foundation Trust, Durham, UK.

Background And Study Aims: Eosinophilic oesophagitis (EoE) is a common disease with a significant impact on physical health and quality of life (QoL). Outcomes and management vary widely, with no agreed UK national guideline. This paper aims to describe an up-to-date description of demographics, clinical spectrum and outcomes for paediatric and adult patients with EoE from the North East of England between 2016 and 2019. Read More

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A chromosomal duplication encompassing IL-33 causes a novel Hyper IgE phenotype characterized by eosinophilic esophagitis and generalized autoimmunity.

Gastroenterology 2022 Apr 27. Epub 2022 Apr 27.

Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, Toronto, Ontario, Canada; SickKids Inflammatory Bowel Disease Centre and Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada. Department of Pediatrics and Biochemistry, University of Toronto, Hospital for Sick Children, Toronto, Ontario, Canada.

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Improving Care in Eosinophil-Associated Diseases: A Charter.

Adv Ther 2022 Apr 30. Epub 2022 Apr 30.

Allergy and Asthma Network, Vienna, VA, USA.

Eosinophil-associated diseases (EADs) are a range of heterogeneous conditions in which eosinophils are believed to play a critical pathological role. EADs include common illnesses such as eosinophilic asthma and chronic rhinosinusitis and rare conditions such as hypereosinophilic syndromes (HES) and eosinophilic gastrointestinal disorders (EGIDs). EADs are associated with substantial burdens for the patient, including chronic, debilitating symptoms, increased financial burden, decreased health-related quality of life, and the need for repeated visits to multiple different healthcare professionals (HCPs), emergency departments, and/or hospitals. Read More

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Esophagogastric complications in radiofrequency and cryoballoon catheter ablation of atrial fibrillation.

J Cardiovasc Electrophysiol 2022 Apr 30. Epub 2022 Apr 30.

Department of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara, Japan.

Introduction: Direct comparison studies about the incidence of esophagogastric complications between radiofrequency (RF) and cryoballoon (CB) catheter ablation (CA) for atrial fibrillation (AF) have been scarce. We sought to elucidate the relationship between the pulmonary vein isolation (PVI) modalities and esophagogastric complications.

Methods: The study population consisted of 254 patients who underwent CA for AF from November 2017 to October 2018. Read More

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