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Esophagus 2018 Dec 13. Epub 2018 Dec 13.

AI Medical Service Inc., Tokyo, Japan.

Background And Aims: The endocytoscopic system (ECS) helps in virtual realization of histology and can aid in confirming histological diagnosis in vivo. We propose replacing biopsy-based histology for esophageal squamous cell carcinoma (ESCC) by using the ECS. We applied deep-learning artificial intelligence (AI) to analyse ECS images of the esophagus to determine whether AI can support endoscopists for the replacement of biopsy-based histology. Read More

Surg Case Rep 2018 Dec 13;4(1):144. Epub 2018 Dec 13.

Department of Surgery, Iwate Medical University School of Medicine, Iwate, Japan.

Background: Gastrointestinal stromal tumors (GISTs) grow relatively slowly and without specific symptoms; therefore, they are typically incidental findings. We report a rare gastric GIST in the mediastinum associated with chest discomfort and an esophageal hiatal hernia.

Case Presentation: An 81-year-old woman with chest discomfort was admitted to the hospital, where barium esophagography showed a sliding esophageal hiatal hernia and a tumor of the lower esophagus and gastric wall. Read More

Curr Hepatol Rep 2018 7;17(4):301-315. Epub 2018 Nov 7.

1Vienna Hepatic Hemodynamic Lab, Medical University of Vienna, Vienna, Austria.

Purpose Of Review: The natural history and classification systems of small varices (≤ 5 mm in diameter) in cirrhotic patients with portal hypertension are summarized. Studies that assessed the course of and therapeutic intervention for small varices are discussed.

Recent Findings: Current non-invasive methods show suboptimal sensitivity to detect small varices in patients with cirrhosis. Read More

Oncoimmunology 2019 2;8(1):e1512458. Epub 2018 Nov 2.

German Cancer Consortium (DKTK), Heidelberg, Germany.

Tumor-infiltrating lymphocytes (TILs) are correlated to prognosis of several kinds of cancer. Most studies focused on T cells, while the role of tumor-associated B cells (TABs) has only recently gained more attention. TABs contain subpopulations with distinct functions, potentially promoting or inhibiting immune responses. Read More

Oncol Lett 2018 Dec 3;16(6):7245-7255. Epub 2018 Oct 3.

Department of Oncology, University of Zagreb School of Medicine, Sisters of Mercy University Hospital Center, University Hospital for Tumors, 10000 Zagreb, Croatia.

Cancer/testis antigens (CTAs) are a large family of tumor-associated antigens expressed in human tumors of different histological origin, but not in normal tissues, with the exception of the testes and placenta. Numerous immunohistochemical studies have reported associations between CTA expression and a negative estrogen receptor (ER) status in breast tumors, and demonstrated that CTAs are frequently expressed in tumors with higher nuclear grade. The expression of CTAs has not been studied as extensively in ductal carcinoma (DCIS) as it has been in invasive breast cancer. Read More

Oncol Lett 2018 Dec 3;16(6):7204-7211. Epub 2018 Oct 3.

Department of Oncology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P.R. China.

Retinoblastoma-binding protein 7 (RBBP7) is an important component of several complexes that regulate chromatin metabolism. It is overexpressed in certain cancer types and serves conflicting roles in tumor progression. In the present study, the expression and roles of RBBP7 were explored in esophageal squamous cell carcinoma (ESCC). Read More

Oncol Lett 2018 Dec 25;16(6):7139-7145. Epub 2018 Sep 25.

Institute of Pathology, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, Germany.

Class III β-tubulin (TUBB3) is a component of microtubules of neuronal cells that is upregulated in various cancer entities. To better understand the role of TUBB3 in upper gastrointestinal tract cancer types, the present study assessed TUBB3 expression in tissue microarrays including 189 gastric and 428 esophageal cancer. TUBB3 expression was detected in 62. Read More

Oncol Lett 2018 Dec 1;16(6):7117-7122. Epub 2018 Oct 1.

Department of Radiology, Jinan Children's Hospital, Jinan, Shandong 250022, P.R. China.

Value of computed tomography (CT) scan and diffusion-weighted imaging (DWI) in the diagnosis and treatment of esophageal cancer was investigated. Seventy-eight patients with esophageal cancer treated in Jinan Central Hospital (Jinan, China) from January 2013 to June 2014 were selected. All patients underwent CT scan and DWI examination, and their clinical history data were analyzed. Read More

Oncol Lett 2018 Dec 27;16(6):7097-7101. Epub 2018 Sep 27.

Department of Cardio-Thoracic Surgery, The Affiliated Jinling Hospital of Nanjing Medical University, Nanjing, Jiangsu 210002, P.R. China.

The present study investigated the association between the G(-248)A single nucleotide polymorphism (SNP) in the promoter region of B-cell lymphoma 2 (Bcl-2) associated X protein (Bax), which is a pro-apoptosis gene and the clinicopathological parameters and prognosis of patients with esophagus cancer. Three genotypes (AA, AG and GG) of Bax G(-248)A SNP were detected in 75 patients with esophageal squamous cell carcinoma (ESCC) via polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP). The expression of Bax in tumor tissues from 75 patients with ESCC and 30 para-carcinoma normal tissues were detected via immunohistochemistry. Read More

Oncol Lett 2018 Dec 1;16(6):6998-7007. Epub 2018 Oct 1.

Department of Research and Development, Shenzhen Institute for Innovation and Translational Medicine, Shenzhen, Guangdong 518120, P.R. China.

This article presented a case of a human leukocyte antigen (HLA)-A2-positive patient with advanced cancer/testis antigen New York esophageal squamous cell carcinoma-1 (NY-ESO-1) expressing lung adenocarcinoma (LADC) who received adoptive cell therapy of T cell receptor engineered-T cells (TCR-T cells) targeting the cancer-testis antigen NY-ESO-1. The appropriate clinical and laboratory assessments were conducted to investigate the safety and efficacy of this therapy for this lung cancer patient. The patient had a clinical response to and was well-tolerated with this therapy in the clinical trial. Read More

Eur Surg 2018 7;50(6):249-255. Epub 2018 Aug 7.

1Department of Surgery, Upper-GI-Service Comprehensive Cancer Center, GET-Unit Medical, University of Vienna, Spitalgasse 23, 1090 Vienna, Austria.

Background: The minimally invasive esophagectomy (MIE) for esophageal cancer was introduced assuming a reduction of morbidity and operation time. After implementation of MIE at our institution, a randomized controlled trial was designed.

Methods: This is a prospective randomized controlled study comparing open (OE) and laparoscopic gastric tube (MIE) formation in Ivor Lewis esophagectomy. Read More

J Pediatr Surg 2018 Nov 7. Epub 2018 Nov 7.

Department of Pediatric Surgery, Hannover Medical School, Carl-Neuberg-Straße 130625, Hannover, Germany. Electronic address:

Europe has changed remarkably over the past decades and so have concepts and outcomes of esophageal atresia repair. In this article, both the efforts to create a united Europe and the achievements in dealing with esophageal atresia from the 1950s on are outlined. Furthermore, this paper deals with the future of pediatric surgery and is focused on two aspects: the "Fourth Industrial Revolution" which builds on the digital revolution, artificial intelligence and robotics, and its potential impact on pediatric surgery and the life of patients. Read More

Am J Surg 2018 Dec 4. Epub 2018 Dec 4.

St. John Hospital & Medical Center, 22101 Moross Rd, Detroit, MI, 48236, USA.

Background: Esophagectomy has high cardiac and pulmonary complication rates that can reach 43% and 58% respectively. The original Ivor Lewis esophagectomy was a two-stage procedure. We revisited this procedure using a hybrid minimally-invasive approach. Read More

Surg Obes Relat Dis 2018 Dec 26;14(12):1911-1913. Epub 2018 Sep 26.

Ultimate Bariatrics, Forth Worth, Texas.

Medicine (Baltimore) 2018 Dec;97(49):e13585

Department of Thoracic Surgery.

Background: The prognostic role of neutrophil-to-lymphocyte ratio (NLR) in esophageal cancer (EC) remains controversial.

Methods: The aim of this study was to evaluate the association between NLR and oncologic outcome of EC patients through a meta-analysis. A systematic search was performed in PubMed, Web of Science and Embase for relevant studies. Read More

Medicine (Baltimore) 2018 Dec;97(49):e13412

Department of Nuclear Medicine, Rabin Medical Center, Beilinson Hospital.

The type of pathological response to neoadjuvant chemoradiation in patients with locally advanced esophageal cancer predicts overall survival (OS).We aimed to assess early 18F-FDG positron emission tomography/computed tomography parameters in predicting the pathological response to neoadjuvant treatment.The cohort included consecutive patients with locally advanced esophageal cancer who underwent baseline 18F-FDG positron emission tomography/computed tomography between September 2006 and February 2015. Read More

Medicine (Baltimore) 2018 Dec;97(49):e13191

Department of Legal and Forensic Medicine, University of Genova, Genova.

Rationale: Spontaneous esophageal rupture (Boerhaave syndrome) is a rare, though frequently fatal, event. It is generally caused by a sudden increase in pressure inside the esophagus. In some cases, full-thickness perforations of the esophagus may develop from previous lesions that initially involve only the esophageal mucosa (Mallory-Weiss syndrome) and which, following further triggering events, give rise to a transmural lesion. Read More

Clin Immunol 2018 Dec 10. Epub 2018 Dec 10.

Sackler Faculty of Medicine, Tel Aviv University, Israel; Zabludowicz Center for Autoimmune Disease, Sheba Medical Center, Tel Hashomer, Israel. Electronic address:

Systemic Sclerosis (SSc) is a rare autoimmune disease that is characterized by a progressive skin fibrosis, an obliteration of the microvasculature and an exaggerated extracellular matrix deposition, which lead to a multisystemic dysfunction. Various pathogenetic mechanisms were described. The lack of a successful therapy make SSc a disease with a poor prognosis. Read More

Innovations (Phila) 2018 Nov/Dec;13(6):391-403

Division of Thoracic Surgery, Robert Tucker Hayes Foundation, University of Texas Southwestern Medical Center, Dallas, TX USA.

Great advances have been made in the surgical management of esophageal disease since the first description of esophageal resection in 1913. We are in the era of minimally invasive esophagectomy. The current three main approaches to an esophagectomy are the Ivor Lewis technique, McKeown technique, and the transhiatal approach to esophagectomy. Read More

Am J Physiol Gastrointest Liver Physiol 2018 Dec 13. Epub 2018 Dec 13.

Cattedra di Gastroenterologia, IRCCS Ospedale Maggiore, Italy.

Background: Jackhammer esophagus (JE) is a hypercontractile disorder, the pathogenesis of which is incompletely understood. Multiple rapid swallows (MRS) and rapid drink challenge (RDC) are complementary tests used during high resolution manometry (HRM) that evaluate inhibitory and excitatory neuromuscular function and latent obstruction respectively. Methods&aim. Read More

Am J Physiol Gastrointest Liver Physiol 2018 Dec 13. Epub 2018 Dec 13.

Section of Neonatology-Pediatric Gastroenterology, The Research Institute at Nationwide Children's Hospital, United States.

Objective: Aims were to: 1) examine pharyngo-esophageal and cardio-respiratory responses to provoking pharyngeal stimuli, and 2) determine potential contributory factors impacting heart rate (HR) changes to provide insight into cardio-respiratory events occurring in preterm infants.

Methods: Forty-eight neonates (29 males, born at 27.7 ± 0. Read More

J Int Med Res 2018 Dec 13:300060518814682. Epub 2018 Dec 13.

Department of General, Visceral and Transplant Surgery, University Medical Center of Johannes Gutenberg University, Mainz, Germany.

We report a case of a 69-year-old patient with esophageal cancer and severe upper gastrointestinal bleeding during neoadjuvant radiochemotherapy who required mass transfusion followed by complex emergency procedures. Despite endoscopic stenting, the bleeding recurred, and thus emergency open surgery was required. Gastric wedge resection of the minor curvature necessitated by perforation caused by the endoscopic stent maneuver and duodenotomy with ligation of the gastroduodenal artery, as the cause of persistent intraluminal bleeding, were performed. Read More

Oncotarget 2018 Nov 13;9(89):35997-36011. Epub 2018 Nov 13.

Department of Immuno-Gene Therapy, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.

MAGE-A4 antigen is a cancer-testis antigen that is frequently expressed in tumor tissues. Cholesteryl pullulan (CHP) is a novel antigen delivery system for cancer vaccines. This study evaluated the safety, immune responses and clinical outcomes of patients who received a CHP-MAGE-A4 vaccine. Read More

Exp Ther Med 2018 Dec 12;16(6):5248-5252. Epub 2018 Oct 12.

Department of Gastroenterology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu 213003, P.R. China.

Effect and prognosis of endoscopic balloon dilatation combined with submucosal triamcinolone acetonide on treating benign esophageal lesions were explored. This retrospective study included patients with esophageal stricture treated in the Department of Gastroenterology, the Third Affiliated Hospital of Soochow University from March 2012 to March 2015. Enrolled patients were divided into the treatment and control group depending on the therapy differences. Read More

Exp Ther Med 2018 Dec 2;16(6):4959-4966. Epub 2018 Oct 2.

College of Acupuncture and Massage, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, P.R. China.

The aim of the present study was to examine microRNA (miRNA or miR)-455-5p expression in esophageal squamous cell carcinoma (ESCC) at the tissue and cellular levels in order to elucidate its biological roles. A total of 60 patients with ESCC were enrolled in the present study and reverse transcription-quantitative polymerase chain reaction was used to measure the expression of miR-455-5p. ESCC Eca109 cells were transfected with miR-NC, miR-455-5p mimics or inhibitor and a Cell Counting Kit-8 assay was used to assess proliferation. Read More

Exp Ther Med 2018 Dec 27;16(6):4765-4771. Epub 2018 Sep 27.

Department of Hepatobiliary Surgery, Third Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei 050051, P.R. China.

The aim of the present study was to investigate the characteristics and progression of intestinal injury at the anhepatic phase in portal hypertensive rats. A total of 120 healthy male Wistar rats were purchased, with 15 rats in the normal control group and 105 rats were assigned to establish a prehepatic portal hypertension model. The 105 model rats were further divided into seven treatment groups following ischemia-reperfusion. Read More

Oncogene 2018 Dec 12. Epub 2018 Dec 12.

Key Laboratory of Liver Disease of Guangdong Province, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou,Guangdong, China.

Tumor-associated lymphangiogenesis has attracted increasing attention because of its potential contribution to lymph node metastasis. However, the molecular mechanisms underlying lymphangiogenesis in cancer remains elusive. In the current study, we demonstrate that tripartite motif-containing 3 (TRIM3) directly interacts with and induces E3 ligase-dependent proteasomal turnover of importin α3 and α-Actinin-4 (ACTN4), which controls nuclear factor kappa B (NF-κB) activity at a well-ordered level. Read More

Nihon Ronen Igakkai Zasshi 2018 ;55(4):668-674

Department of Internal Medicine II, Shimane University, Faculty of Medicine.

An 84-year-old male with dysphagia was referred to our hospital. Chest computed tomography (CT) showed a rectangular structure along with artificial air in the cervical esophagus. Endoscopy revealed a 'shogi' game piece in the same region shown in CT findings, which was recovered during the endoscopic procedure. Read More

Ann Thorac Cardiovasc Surg 2018 Dec 11. Epub 2018 Dec 11.

Department of Surgery, Faculty of Medicine, Miyazaki University Hospital, Miyazaki, Miyazaki, Japan.

Approximately half of the patients with esophageal cancer are diagnosed at an advanced stage with inoperable disease. The technique of bypass surgery, which is one of the palliative procedures for esophageal cancer, usually requires the insertion of a drainage tube for clearing secretions from the blind remnant esophagus. Since the artificial drainage tube is sometimes problematic for the patient after discharge from the hospital, drainage tubeless (DRESS) surgery might be preferable. Read More

Turk J Gastroenterol 2018 Dec 12. Epub 2018 Dec 12.

Department Clinical Pathology, Al-Azhar University School of Medicine, New Damietta, Damietta, Egypt.

Background/aims: Insulin resistance (IR) is closely linked with chronic hepatitis C virus (HCV) and its complications, particularly hepatic fibrosis. The aim of the present study was to investigate some biochemical markers that are potentially related to IR as predictors of esophageal varices (EV) in patients with compensated HCV cirrhosis who do not have diabetes or metabolic syndrome.

Materials And Methods: One hundred subjects without diabetes with compensated HCV-related cirrhosis who did not fulfill the diagnostic criteria of metabolic syndrome were subjected to clinical, laboratory, ultrasonographic, and endoscopic assessments. Read More

Turk J Gastroenterol 2018 Dec 12. Epub 2018 Dec 12.

Department of Gastroenterology, Eskisehir Osmangazi University School of Medicine, Eskişehir, Turkey.

BMC Cancer 2018 Dec 12;18(1):1244. Epub 2018 Dec 12.

Departments of Surgery, College of Medicine, Hanyang University222 Wangsimni-ro, Seongdong-gu, Seoul, 04763, South Korea.

Background: SSBP2, single-stranded DNA binding protein 2, is a subunit of the ssDNA-binding complex that is involved in the maintenance of genome stability. The majority of previous studies have suggested a tumor-suppressive role of SSBP2, which is silenced by promoter hypermethylation in several human malignancies, such as hematologic malignancies, prostate cancer, esophageal squamous cell carcinoma, ovarian cancer, and gallbladder cancer. However, an oncogenic role of SSBP2 has been suggested in glioblastoma patients. Read More

BMC Pediatr 2018 Dec 12;18(1):385. Epub 2018 Dec 12.

Department of Pediatric Surgery, West China Hospital of Sichuan University, #37 Guo-Xue-Xiang, Chengdu, 610041, China.

Background: The transanastomotic feeding tube (TAFT) is widely used around the world in patients with esophageal atresia (EA). However, the safety of the use of TAFT is still unknown and remains to be clarified.

Methods: The following electronic databases were searched: PubMed, EMBASE and Cochrane. Read More

Zhonghua Yi Xue Za Zhi 2018 Dec;98(46):3778-3783

Department of Anesthesiology, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450003, China.

To investigate the effects of dexmedetomidine on perioperative stress and postoperative pain in patients with radical resection of esophageal cancer under combined thoracoscope and laparoscope. In this prospective study, one hundred patients undergoing radical resection of esophageal cancer in Affiliated Cancer Hospital of Zhengzhou University from January 2016 to October 2017, were randomly divided into control group (group C) and dexmedetomidine group (group D), =50. All patients were anaesthetized (induced and maintained) with intravenous target-controlled infusion(TCl) of propofol and remifentanil, and intermittent intravenous injection of cisatracuriumbesylate. Read More

J Card Surg 2018 Dec 7. Epub 2018 Dec 7.

Department of Critical Care Medicine, St. John's Medical College Hospital, Bangalore, India.

Front Immunol 2018 22;9:2624. Epub 2018 Nov 22.

Sean N. Parker Center for Allergy and Asthma Research, Stanford University School of Medicine, Stanford, CA, United States.

Oral immunotherapy (OIT) is an emerging treatment for food allergy. While desensitization is achieved in most subjects, many experience gastrointestinal symptoms and few develop eosinophilic gastrointestinal disease. It is unclear whether these subjects have subclinical gastrointestinal eosinophilia (GE) at baseline. Read More

Front Endocrinol (Lausanne) 2018 20;9:679. Epub 2018 Nov 20.

Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark.

Patients with goiter referred for thyroidectomy report swallowing difficulties. This might be associated with esophageal compression and deviation as this is present in a significant number of patients. Studies on how goiter and subsequently its treatment affect the esophagus are sparse and point in various directions. Read More

Clin Mol Allergy 2018 3;16:25. Epub 2018 Dec 3.

1Department of Surgery, Medicine, Molecular Biology and Critical Care, University of Pisa, Pisa, Italy.

Background: According to ATS/ERS document on severe asthma (SA), the management of these patients requires the identification and proper treatment of comorbidities, which can influence the control of asthma.

Methods: The aim of this study was to assess the independent effect of different comorbidities on clinical, functional and biologic features of SA. Seventy-two patients with SA according to GINA guidelines were examined. Read More

Physiol Meas 2018 Nov 14. Epub 2018 Nov 14.

Department of Biomedical Engineering, Seoul National University, Seoul, KOREA, REPUBLIC OF.

Objectives: This paper introduces a mathematical model that can estimate deep brain temperature during therapeutic hypothermia based on a double sensor method. Although the cerebral temperature is more important than the non-cerebral core temperature during therapeutic hypothermia, pulmonary artery, rectal, and esophageal measurements (i.e. Read More

J Cell Physiol 2018 Dec 6. Epub 2018 Dec 6.

Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China.

Esophageal squamous cell carcinoma (ESCC) is one of the most common digestive tumors worldwide. The Mucin 1 (MUC1) heterodimeric protein has been confirmed that is overexpressed in ESCC and induced adverse outcomes. However, the detailed mechanism(s) remained challenging. Read More

World J Surg 2018 Dec 6. Epub 2018 Dec 6.

Gastrointestinal and Minimally Invasive Surgery, The Oregon Clinic, 4805 NE Glisan St, Suite 6N60, Portland, OR, 97213, USA.

Background: Dysphagia after Nissen fundoplication is challenging for patients. High-resolution manometry (HRM) has rarely been studied preoperatively to determine whether manometry values correlated with postoperative dysphagia after fundoplication. We aim to determine whether HRM criteria could predict dysphagia after Nissen fundoplication. Read More

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Oct;43(10):1048-1053

Department of Cardiothoracic Surgery, Second Xiangya Hospital, Central South University, Changsha 410011, China.

Objective: To explore the changes of serum microRNA-183 levels in patients with esophageal squamous cell carcinoma (ESCC) and its clinical significance.
 Methods: Fifty-one patients with ESCC and 55 healthy subjects from Department of Cardiothoracic Surgery, Second Xiangya Hospital, Central South Unicersity were selected for this study. Real-time quantitative polymerase chain reaction (RT-qPCR) was used to determine the level of miRNA-183 in serum samples. Read More

Dis Esophagus 2018 Dec 12. Epub 2018 Dec 12.

Gastroenterology, New York University Langone Medical Center, New York, NY, USA.

The 4-quadrant forceps biopsy (FB) protocol for identifying Barrett's esophagus (BE) and esophageal dysplasia (ED) suffers from poor sensitivity due to significant sampling error. We investigated the benefit of wide-area transepithelial sampling with 3-dimensional computer-assisted analysis (WATS) used adjunctively to the combination of random and targeted FB in the detection of ED, and as a secondary outcome, BE. In this multicenter prospective trial, community endoscopists at 21 sites utilized WATS as an adjunct to both targeted and random FB in patients undergoing BE screening and surveillance. Read More

Dig Dis 2018 Dec 12:1-10. Epub 2018 Dec 12.

Clinic for Gastroenterology and Hepatology, Clinical Center of Serbia, Belgrade, Serbia.

Superficial neoplastic lesions of the digestive tract are usually asymptomatic, and often represent incidental findings on endoscopy. The Paris Classification was developed for the systematic evaluation of superficial lesions of the oesophagus, stomach and colon. The significance of this classification in clinical practice is that it allows the depth of invasion to be estimated. Read More

Rev Gastroenterol Peru 2018 Jul-Sep;38(3):293-296

Escuela de Medicina, Universidad Peruana de Ciencias Aplicadas. Lima, Perú; Departamento de Medicina Interna, Hospital Nacional Hipólito Unanue. Lima, Perú.

Neuroendocrine carcinoma of esophagus represents less than 2% of cases of cancer of the esophagus. This presentation is extremely unusual, as this type of carcinoma typically presents with greater frequency in bronchopulmonary regions. The symptoms are usually associated with esophageal obstruction and include odynophagia, dysphagia and weight loss and are not usually associated with Carcinoid syndrome. Read More

J Pediatr Gastroenterol Nutr 2018 Dec 11. Epub 2018 Dec 11.

Institute of Gastroenterology, Nutrition, and Liver Disease, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.

Objectives: Recommendations for diagnosing and treating eosinophilic esophagitis (EoE) are evolving; however, information on real world clinical practice is lacking. To assess the practices of pediatric gastroenterologists diagnosing and treating EoE and to identify the triggering allergens in European children.

Methods: Retrospective anonymized data were collected from 26 European pediatric gastroenterology centers in 13 countries. Read More

J Pediatr Gastroenterol Nutr 2018 Dec 11. Epub 2018 Dec 11.

Division of Pediatric Gastroenterology, Hepatology and Nutrition.

Objective: Recent studies show increased serum and esophageal IgG4 in patients with eosinophilic esophagitis (EoE), suggesting a possible IgG4-involved process. The role of IgG4 in pediatric EoE has not been extensively investigated. Our aim was to analyze IgG4 in esophageal tissue in children in parallel to that in adults with EoE. Read More

Arq Bras Cir Dig 2018 Dec 6;31(4):e1405. Epub 2018 Dec 6.

Digestive Diseases Surgical Unit and Gastrocenter, Department of Surgery, School of Medical Sciences, State University of Campinas - UNICAMP , Campinas, SP, Brazil.

Background: Esophageal squamous cell carcinoma is an aggressive neoplasia that requires a multidisciplinary treatment in which survival and prognosis are still not satisfactory. The complete pathologic response to neoadjuvant chemotherapy and radiotherapy is considered a good prognosis factor, and esophagectomy is indicated.

Aim: Survival analysis of cases with pathologic complete response (ypT0 ypN0) to neoadjuvant chemotherapy and/or radiotherapy, submmitted to esophagectomy. Read More

J Cancer Res Ther 2018 Dec;14(Supplement):S1173-S1177

Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan 250012, China.

Aim Of The Study: Several studies have evaluated the correlation between xeroderma pigmentosum Group A (XPA) A23G polymorphism (rs 1800975) and esophageal cancer in Chinese people. However, the results are inconsistent. To assess the effects of XPA A23G variants on the risk for development of esophageal cancer in the Chinese population, a meta-analysis was performed. Read More

J Cancer Res Ther 2018 Dec;14(Supplement):S1135-S1140

Department of General Surgery, Peking University International Hospital, Beijing 100026, China.

Background: The exact molecular mechanism of esophageal squamous cell carcinoma (ESCC) is still unknown, and the prognosis of ESCC has not been significantly improved.

Objective: To understand the molecular mechanism of ESCC, differential modules (DMs) and key genes were identified through conducting analysis on the differential co-expression network (DCN) based on the gene expression profiles of ESCC and protein-protein interaction (PPI) data.

Materials And Methods: First, gene expression profiles of ESCC and PPI data recruiting and preprocessing were conducted; then, a DCN was constructed based on the gene co-expression and gene differential expression in ESCC; in the following, candidate DMs were mined from DCN through a systemic module searching strategy, and significance analysis was performed on candidate DMs to identify DMs; moreover, significant genes contained in the DMs were analyzed to identify the underlying biomarkers for ESCC. Read More