132,815 results match your criteria Esophageal Motility Disorders


NF45 promotes esophageal squamous carcinoma cell invasion by increasing Rac1 activity through 14-3-3ε protein.

Arch Biochem Biophys 2018 Dec 11. Epub 2018 Dec 11.

Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:

Nuclear factor 45 (NF-45) has been found to be markedly upregulated in several cancers, including esophageal squamous cell carcinoma (ESCC). However, the molecular mechanisms underlying its functions remain unclear. In this study, we confirm that overexpression of NF45 was frequently detected in ESCC tissues and was associated with poor outcome. Read More

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December 2018

Alcohol and gastrointestinal cancers.

Curr Opin Gastroenterol 2018 Dec 12. Epub 2018 Dec 12.

Pancreato-Biliary Endoscopy Division and Endosonography Division, Pancreas Translational and Clinical Research Centre, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan.

Purpose Of Review: Alcohol is a type I carcinogen and the WHO stated that it caused 5% of all deaths in 2016, of which 13% because of cancers. Among digestive tract cancers, this association is clear for esophageal, liver and colorectal cancer, and more debated for gastric and pancreatic cancer. The present review will revise recent evidence on epidemiologic association and mechanisms linking alcohol with the risk of esophageal, gastric, colorectal and pancreatic cancers. Read More

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December 2018

Single-incision laparoscopy-assisted gastric transposition combined with thoracoscopic esophagectomy for esophageal replacement.

Asian J Endosc Surg 2018 Dec 13. Epub 2018 Dec 13.

Department of Pediatric Surgery, Ege University Faculty of Medicine, Izmir, Turkey.

Introduction: We present a novel approach to single-incision laparoscopy-assisted gastric transposition combined with thoracoscopic esophagectomy in a child with long-segment corrosive esophageal stricture (CES).

Materials And Surgical Technique: A 2.5-year-old boy with a history of caustic ingestion underwent periodic esophageal dilatations at 3-week intervals, four sessions of topical mitomycin C application, and a strict antacid/H antagonist therapy for 8 months. Read More

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December 2018

Characterization of peristaltic motility in the striated muscle portion of the esophagus using a novel in vivo method in rats.

Neurogastroenterol Motil 2018 Dec 14:e13518. Epub 2018 Dec 14.

Laboratory of Physiology, Department of Basic Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu University, Gifu, Japan.

Background: Esophageal peristalsis is controlled by the brainstem via vago-vagal reflex. However, the precise regulatory mechanisms in the striated muscle portion are largely unknown. The aim of this study was to characterize peristaltic motility in the portion of the esophagus using a novel in vivo method in rats. Read More

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December 2018

Clinical investigation of esophageal injury from cryoballoon ablation of persistent atrial fibrillation.

Pacing Clin Electrophysiol 2018 Dec 14. Epub 2018 Dec 14.

Heart center, Japan Red Cross Yokohama City Bay Hospital, Yokohama City, Japan.

Background: The cryoballoon (CB) can be utilized for extra pulmonary vein (PV) ablation such as for a left atrial (LA) posterior wall (LAPW) isolation. However, scrutiny of the esophageal injuries during the LAPW isolation has never been performed. We sought to thoroughly investigate the esophageal lesions (ELs) and gastric hypomotility (GH) caused by an LAPW isolation using a CB. Read More

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December 2018

Associated anomalies in cases with anorectal anomalies.

Am J Med Genet A 2018 Dec 12:e40530. Epub 2018 Dec 12.

Laboratoire de Génétique Médicale, Faculté de Médecine, Université de Strasbourg, Strasbourg cedex, France.

Anorectal anomalies (ARA) are common congenital anomalies. The etiology of ARA is unclear and its pathogenesis is controversial. Cases with ARA often have other non-ARA-associated congenital anomalies. Read More

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December 2018

High-dose versus standard-dose radiation therapy for cervical esophageal cancer: A retrospective single-institution study.

Head Neck 2018 Dec 12. Epub 2018 Dec 12.

Departments of Radiation Oncology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background: To evaluate the role of definitive radiotherapy using higher-than-standard-dose radiation of 50 Gy for carcinoma of the cervical esophagus (CCE).

Methods: We reviewed 79 patients with stage I-III CCE, treated between 2000 and 2012. Patients received 5-fluorouracil/cisplatin-based chemotherapy concurrently and were divided into high-dose (≥59. Read More

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December 2018

Alkaline, protein, low-fat and low-acid diet in laryngopharyngeal reflux disease: Our experience on 65 patients.

Clin Otolaryngol 2018 Dec 11. Epub 2018 Dec 11.

Laboratory of Anatomy and Cell Biology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium.

The respect of diet and lifestyle modifications could be associated with better improvement of laryngopharyngeal symptoms, perceptual dysphonia, and acoustic measurements. The potential positive impact of alkaline, protein, low-fat, low-acid diet could be explained by many physiological effects on esophageal sphincter tonicity, acid and pepsin productions, and gastric emptying time. Future controlled prospective studies are needed to confirm the potential key role of alkaline, protein, low-fat, low-acid diet and lifestyle modifications in the clinical improvement of patients with suspected LPR disease. Read More

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December 2018

Endoscopic submucosal dissection followed by chemoradiotherapy for superficial esophageal cancer: choice of new approach.

Radiat Oncol 2018 Dec 14;13(1):246. Epub 2018 Dec 14.

Department of Radiology, Kyoto Prefectural University Graduate School of Medical Science, 465 Kajiicho Kawaramachi Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.

Background: The standard treatment for superficial esophageal cancer (SEC) involving muscularis mucosal (T1a-MM) or submucosal (T1b) invasion has been the surgical resection of the esophagus. However, esophagectomy with extended lymph node dissection is highly invasive. Recent reports have shown that endoscopic submucosal dissection (ESD) followed by chemoradiotherapy (CRT) has promising results and might become a new therapeutic approach. Read More

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December 2018

Angiographic right heart hypermobility as a sign of non-cardiac pathology in the setting of ST elevation.

J Cardiol Cases 2013 Jul 17;8(1):e36-e38. Epub 2013 Apr 17.

Lancashire Cardiac Centre, Blackpool Victoria Hospital, Whinney Heys Rd, Blackpool, Lancashire FY3 8NR, UK.

Esophageal perforation (Boerhaave's syndrome) is a severe life-threatening disorder. Diagnosis and treatment are often delayed due to the wide variety of presenting symptoms. This case report details an unusual presentation of Boerhaave's syndrome in a 48-year-old man mimicking an acute anterior myocardial infarction. Read More

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Aortic prosthetic graft infection accompanied with esophagomediastinal fistulas: A case report.

J Cardiol Cases 2012 Aug 6;6(2):e51-e54. Epub 2012 Jun 6.

Tenri Shirakawa Branch Hospital, Nara, Japan.

Prosthetic graft infection is difficult to diagnose early, and hence, is associated with high mortality and morbidity rates. A 63-year-old man who had undergone surgical prosthetic replacement for an inflammatory thoracic aortic aneurysm 10 months previously visited our emergency room, complaining of chills, shivering, frequent vomiting, and back pain. He was diagnosed with severe sepsis, and a blood culture detected and . Read More

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Diagnosis using deep-learning artificial intelligence based on the endocytoscopic observation of the esophagus.

Esophagus 2018 Dec 13. Epub 2018 Dec 13.

AI Medical Service Inc., Tokyo, Japan.

Background And Aims: The endocytoscopic system (ECS) helps in virtual realization of histology and can aid in confirming histological diagnosis in vivo. We propose replacing biopsy-based histology for esophageal squamous cell carcinoma (ESCC) by using the ECS. We applied deep-learning artificial intelligence (AI) to analyse ECS images of the esophagus to determine whether AI can support endoscopists for the replacement of biopsy-based histology. Read More

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December 2018

Giant gastrointestinal stromal tumor of the mediastinum associated with an esophageal hiatal hernia and chest discomfort: a case report.

Surg Case Rep 2018 Dec 13;4(1):144. Epub 2018 Dec 13.

Department of Surgery, Iwate Medical University School of Medicine, Iwate, Japan.

Background: Gastrointestinal stromal tumors (GISTs) grow relatively slowly and without specific symptoms; therefore, they are typically incidental findings. We report a rare gastric GIST in the mediastinum associated with chest discomfort and an esophageal hiatal hernia.

Case Presentation: An 81-year-old woman with chest discomfort was admitted to the hospital, where barium esophagography showed a sliding esophageal hiatal hernia and a tumor of the lower esophagus and gastric wall. Read More

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December 2018

Small Esophageal Varices in Patients with Cirrhosis-Should We Treat Them?

Curr Hepatol Rep 2018 7;17(4):301-315. Epub 2018 Nov 7.

1Vienna Hepatic Hemodynamic Lab, Medical University of Vienna, Vienna, Austria.

Purpose Of Review: The natural history and classification systems of small varices (≤ 5 mm in diameter) in cirrhotic patients with portal hypertension are summarized. Studies that assessed the course of and therapeutic intervention for small varices are discussed.

Recent Findings: Current non-invasive methods show suboptimal sensitivity to detect small varices in patients with cirrhosis. Read More

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November 2018

B cells in esophago-gastric adenocarcinoma are highly differentiated, organize in tertiary lymphoid structures and produce tumor-specific antibodies.

Oncoimmunology 2019 2;8(1):e1512458. Epub 2018 Nov 2.

German Cancer Consortium (DKTK), Heidelberg, Germany.

Tumor-infiltrating lymphocytes (TILs) are correlated to prognosis of several kinds of cancer. Most studies focused on T cells, while the role of tumor-associated B cells (TABs) has only recently gained more attention. TABs contain subpopulations with distinct functions, potentially promoting or inhibiting immune responses. Read More

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November 2018

Possible predictive role of cancer/testis antigens in breast ductal carcinoma .

Oncol Lett 2018 Dec 3;16(6):7245-7255. Epub 2018 Oct 3.

Department of Oncology, University of Zagreb School of Medicine, Sisters of Mercy University Hospital Center, University Hospital for Tumors, 10000 Zagreb, Croatia.

Cancer/testis antigens (CTAs) are a large family of tumor-associated antigens expressed in human tumors of different histological origin, but not in normal tissues, with the exception of the testes and placenta. Numerous immunohistochemical studies have reported associations between CTA expression and a negative estrogen receptor (ER) status in breast tumors, and demonstrated that CTAs are frequently expressed in tumors with higher nuclear grade. The expression of CTAs has not been studied as extensively in ductal carcinoma (DCIS) as it has been in invasive breast cancer. Read More

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December 2018

RBBP7 is a prognostic biomarker in patients with esophageal squamous cell carcinoma.

Oncol Lett 2018 Dec 3;16(6):7204-7211. Epub 2018 Oct 3.

Department of Oncology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P.R. China.

Retinoblastoma-binding protein 7 (RBBP7) is an important component of several complexes that regulate chromatin metabolism. It is overexpressed in certain cancer types and serves conflicting roles in tumor progression. In the present study, the expression and roles of RBBP7 were explored in esophageal squamous cell carcinoma (ESCC). Read More

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December 2018

High expression of class III β-tubulin in upper gastrointestinal cancer types.

Oncol Lett 2018 Dec 25;16(6):7139-7145. Epub 2018 Sep 25.

Institute of Pathology, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, Germany.

Class III β-tubulin (TUBB3) is a component of microtubules of neuronal cells that is upregulated in various cancer entities. To better understand the role of TUBB3 in upper gastrointestinal tract cancer types, the present study assessed TUBB3 expression in tissue microarrays including 189 gastric and 428 esophageal cancer. TUBB3 expression was detected in 62. Read More

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December 2018
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CT scan and magnetic resonance diffusion-weighted imaging in the diagnosis and treatment of esophageal cancer.

Oncol Lett 2018 Dec 1;16(6):7117-7122. Epub 2018 Oct 1.

Department of Radiology, Jinan Children's Hospital, Jinan, Shandong 250022, P.R. China.

Value of computed tomography (CT) scan and diffusion-weighted imaging (DWI) in the diagnosis and treatment of esophageal cancer was investigated. Seventy-eight patients with esophageal cancer treated in Jinan Central Hospital (Jinan, China) from January 2013 to June 2014 were selected. All patients underwent CT scan and DWI examination, and their clinical history data were analyzed. Read More

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December 2018
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Correlation between Bax gene polymorphisms and esophagus cancer.

Oncol Lett 2018 Dec 27;16(6):7097-7101. Epub 2018 Sep 27.

Department of Cardio-Thoracic Surgery, The Affiliated Jinling Hospital of Nanjing Medical University, Nanjing, Jiangsu 210002, P.R. China.

The present study investigated the association between the G(-248)A single nucleotide polymorphism (SNP) in the promoter region of B-cell lymphoma 2 (Bcl-2) associated X protein (Bax), which is a pro-apoptosis gene and the clinicopathological parameters and prognosis of patients with esophagus cancer. Three genotypes (AA, AG and GG) of Bax G(-248)A SNP were detected in 75 patients with esophageal squamous cell carcinoma (ESCC) via polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP). The expression of Bax in tumor tissues from 75 patients with ESCC and 30 para-carcinoma normal tissues were detected via immunohistochemistry. Read More

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December 2018

Treatment of metastatic non-small cell lung cancer with NY-ESO-1 specific TCR engineered-T cells in a phase I clinical trial: A case report.

Oncol Lett 2018 Dec 1;16(6):6998-7007. Epub 2018 Oct 1.

Department of Research and Development, Shenzhen Institute for Innovation and Translational Medicine, Shenzhen, Guangdong 518120, P.R. China.

This article presented a case of a human leukocyte antigen (HLA)-A2-positive patient with advanced cancer/testis antigen New York esophageal squamous cell carcinoma-1 (NY-ESO-1) expressing lung adenocarcinoma (LADC) who received adoptive cell therapy of T cell receptor engineered-T cells (TCR-T cells) targeting the cancer-testis antigen NY-ESO-1. The appropriate clinical and laboratory assessments were conducted to investigate the safety and efficacy of this therapy for this lung cancer patient. The patient had a clinical response to and was well-tolerated with this therapy in the clinical trial. Read More

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December 2018

Morbidity in open versus minimally invasive hybrid esophagectomy (MIOMIE): Long-term results of a randomized controlled clinical study.

Eur Surg 2018 7;50(6):249-255. Epub 2018 Aug 7.

1Department of Surgery, Upper-GI-Service Comprehensive Cancer Center, GET-Unit Medical, University of Vienna, Spitalgasse 23, 1090 Vienna, Austria.

Background: The minimally invasive esophagectomy (MIE) for esophageal cancer was introduced assuming a reduction of morbidity and operation time. After implementation of MIE at our institution, a randomized controlled trial was designed.

Methods: This is a prospective randomized controlled study comparing open (OE) and laparoscopic gastric tube (MIE) formation in Ivor Lewis esophagectomy. Read More

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Esophageal atresia, Europe, and the future: BAPS Journal of Pediatric Surgery Lecture.

Authors:
Benno Ure

J Pediatr Surg 2018 Nov 7. Epub 2018 Nov 7.

Department of Pediatric Surgery, Hannover Medical School, Carl-Neuberg-Straße 130625, Hannover, Germany. Electronic address:

Europe has changed remarkably over the past decades and so have concepts and outcomes of esophageal atresia repair. In this article, both the efforts to create a united Europe and the achievements in dealing with esophageal atresia from the 1950s on are outlined. Furthermore, this paper deals with the future of pediatric surgery and is focused on two aspects: the "Fourth Industrial Revolution" which builds on the digital revolution, artificial intelligence and robotics, and its potential impact on pediatric surgery and the life of patients. Read More

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November 2018

The original Ivor Lewis two stage esophagectomy revisited in the era of minimally invasive surgery.

Am J Surg 2018 Dec 4. Epub 2018 Dec 4.

St. John Hospital & Medical Center, 22101 Moross Rd, Detroit, MI, 48236, USA.

Background: Esophagectomy has high cardiac and pulmonary complication rates that can reach 43% and 58% respectively. The original Ivor Lewis esophagectomy was a two-stage procedure. We revisited this procedure using a hybrid minimally-invasive approach. Read More

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December 2018

Successful management of early gastrogastric fistula using fully covered esophageal stent.

Surg Obes Relat Dis 2018 Dec 26;14(12):1911-1913. Epub 2018 Sep 26.

Ultimate Bariatrics, Forth Worth, Texas.

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December 2018

Prognostic role of neutrophil-lymphocyte ratio in esophageal cancer: A systematic review and meta-analysis.

Medicine (Baltimore) 2018 Dec;97(49):e13585

Department of Thoracic Surgery.

Background: The prognostic role of neutrophil-to-lymphocyte ratio (NLR) in esophageal cancer (EC) remains controversial.

Methods: The aim of this study was to evaluate the association between NLR and oncologic outcome of EC patients through a meta-analysis. A systematic search was performed in PubMed, Web of Science and Embase for relevant studies. Read More

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December 2018

Baseline 18F-FDG PET/CT as predictor of the pathological response to neoadjuvant therapy in esophageal cancer: A retrospective study.

Medicine (Baltimore) 2018 Dec;97(49):e13412

Department of Nuclear Medicine, Rabin Medical Center, Beilinson Hospital.

The type of pathological response to neoadjuvant chemoradiation in patients with locally advanced esophageal cancer predicts overall survival (OS).We aimed to assess early 18F-FDG positron emission tomography/computed tomography parameters in predicting the pathological response to neoadjuvant treatment.The cohort included consecutive patients with locally advanced esophageal cancer who underwent baseline 18F-FDG positron emission tomography/computed tomography between September 2006 and February 2015. Read More

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December 2018

Transition of a Mallory-Weiss syndrome to a Boerhaave syndrome confirmed by anamnestic, necroscopic, and autopsy data: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13191

Department of Legal and Forensic Medicine, University of Genova, Genova.

Rationale: Spontaneous esophageal rupture (Boerhaave syndrome) is a rare, though frequently fatal, event. It is generally caused by a sudden increase in pressure inside the esophagus. In some cases, full-thickness perforations of the esophagus may develop from previous lesions that initially involve only the esophageal mucosa (Mallory-Weiss syndrome) and which, following further triggering events, give rise to a transmural lesion. Read More

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December 2018
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Intravenous Immunoglobulin (IVIG) in the vanguard therapy of Systemic Sclerosis.

Clin Immunol 2018 Dec 10. Epub 2018 Dec 10.

Sackler Faculty of Medicine, Tel Aviv University, Israel; Zabludowicz Center for Autoimmune Disease, Sheba Medical Center, Tel Hashomer, Israel. Electronic address:

Systemic Sclerosis (SSc) is a rare autoimmune disease that is characterized by a progressive skin fibrosis, an obliteration of the microvasculature and an exaggerated extracellular matrix deposition, which lead to a multisystemic dysfunction. Various pathogenetic mechanisms were described. The lack of a successful therapy make SSc a disease with a poor prognosis. Read More

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December 2018

Minimally Invasive and Robotic Esophagectomy: A Review.

Innovations (Phila) 2018 Nov/Dec;13(6):391-403

Division of Thoracic Surgery, Robert Tucker Hayes Foundation, University of Texas Southwestern Medical Center, Dallas, TX USA.

Great advances have been made in the surgical management of esophageal disease since the first description of esophageal resection in 1913. We are in the era of minimally invasive esophagectomy. The current three main approaches to an esophagectomy are the Ivor Lewis technique, McKeown technique, and the transhiatal approach to esophagectomy. Read More

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December 2018

PROVOCATIVE TESTING IN PATIENTS WITH JACKHAMMER ESOPHAGUS: EVIDENCE FOR ALTERED NEURAL CONTROL.

Am J Physiol Gastrointest Liver Physiol 2018 Dec 13. Epub 2018 Dec 13.

Cattedra di Gastroenterologia, IRCCS Ospedale Maggiore, Italy.

Background: Jackhammer esophagus (JE) is a hypercontractile disorder, the pathogenesis of which is incompletely understood. Multiple rapid swallows (MRS) and rapid drink challenge (RDC) are complementary tests used during high resolution manometry (HRM) that evaluate inhibitory and excitatory neuromuscular function and latent obstruction respectively. Methods&aim. Read More

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December 2018

Pharyngo-Esophageal and Cardio-Respiratory Interactions: Potential Implications for Premature Infants at-risk of Clinically Significant Cardiorespiratory Events.

Am J Physiol Gastrointest Liver Physiol 2018 Dec 13. Epub 2018 Dec 13.

Section of Neonatology-Pediatric Gastroenterology, The Research Institute at Nationwide Children's Hospital, United States.

Objective: Aims were to: 1) examine pharyngo-esophageal and cardio-respiratory responses to provoking pharyngeal stimuli, and 2) determine potential contributory factors impacting heart rate (HR) changes to provide insight into cardio-respiratory events occurring in preterm infants.

Methods: Forty-eight neonates (29 males, born at 27.7 ± 0. Read More

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December 2018

Fully robotic Ivor-Lewis esophagectomy (RAMIE4) for esophageal cancer after emergency surgery and ligation of the gastroduodenal artery.

J Int Med Res 2018 Dec 13:300060518814682. Epub 2018 Dec 13.

Department of General, Visceral and Transplant Surgery, University Medical Center of Johannes Gutenberg University, Mainz, Germany.

We report a case of a 69-year-old patient with esophageal cancer and severe upper gastrointestinal bleeding during neoadjuvant radiochemotherapy who required mass transfusion followed by complex emergency procedures. Despite endoscopic stenting, the bleeding recurred, and thus emergency open surgery was required. Gastric wedge resection of the minor curvature necessitated by perforation caused by the endoscopic stent maneuver and duodenotomy with ligation of the gastroduodenal artery, as the cause of persistent intraluminal bleeding, were performed. Read More

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December 2018

NY-ESO-1 antigen expression and immune response are associated with poor prognosis in MAGE-A4-vaccinated patients with esophageal or head/neck squamous cell carcinoma.

Oncotarget 2018 Nov 13;9(89):35997-36011. Epub 2018 Nov 13.

Department of Immuno-Gene Therapy, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.

MAGE-A4 antigen is a cancer-testis antigen that is frequently expressed in tumor tissues. Cholesteryl pullulan (CHP) is a novel antigen delivery system for cancer vaccines. This study evaluated the safety, immune responses and clinical outcomes of patients who received a CHP-MAGE-A4 vaccine. Read More

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November 2018

Endoscopic balloon dilation and submucosal injection of triamcinolone acetonide in the treatment of esophageal stricture: A single-center retrospective study.

Exp Ther Med 2018 Dec 12;16(6):5248-5252. Epub 2018 Oct 12.

Department of Gastroenterology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu 213003, P.R. China.

Effect and prognosis of endoscopic balloon dilatation combined with submucosal triamcinolone acetonide on treating benign esophageal lesions were explored. This retrospective study included patients with esophageal stricture treated in the Department of Gastroenterology, the Third Affiliated Hospital of Soochow University from March 2012 to March 2015. Enrolled patients were divided into the treatment and control group depending on the therapy differences. Read More

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December 2018

Inhibitory effect of microRNA-455-5p on biological functions of esophageal squamous cell carcinoma Eca109 cells via Rab31.

Exp Ther Med 2018 Dec 2;16(6):4959-4966. Epub 2018 Oct 2.

College of Acupuncture and Massage, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, P.R. China.

The aim of the present study was to examine microRNA (miRNA or miR)-455-5p expression in esophageal squamous cell carcinoma (ESCC) at the tissue and cellular levels in order to elucidate its biological roles. A total of 60 patients with ESCC were enrolled in the present study and reverse transcription-quantitative polymerase chain reaction was used to measure the expression of miR-455-5p. ESCC Eca109 cells were transfected with miR-NC, miR-455-5p mimics or inhibitor and a Cell Counting Kit-8 assay was used to assess proliferation. Read More

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December 2018

Characterization and evolution of intestine injury at the anhepatic phase in portal hypertensive rats.

Exp Ther Med 2018 Dec 27;16(6):4765-4771. Epub 2018 Sep 27.

Department of Hepatobiliary Surgery, Third Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei 050051, P.R. China.

The aim of the present study was to investigate the characteristics and progression of intestinal injury at the anhepatic phase in portal hypertensive rats. A total of 120 healthy male Wistar rats were purchased, with 15 rats in the normal control group and 105 rats were assigned to establish a prehepatic portal hypertension model. The 105 model rats were further divided into seven treatment groups following ischemia-reperfusion. Read More

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December 2018

Targeting TRIM3 deletion-induced tumor-associated lymphangiogenesis prohibits lymphatic metastasis in esophageal squamous cell carcinoma.

Oncogene 2018 Dec 12. Epub 2018 Dec 12.

Key Laboratory of Liver Disease of Guangdong Province, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou,Guangdong, China.

Tumor-associated lymphangiogenesis has attracted increasing attention because of its potential contribution to lymph node metastasis. However, the molecular mechanisms underlying lymphangiogenesis in cancer remains elusive. In the current study, we demonstrate that tripartite motif-containing 3 (TRIM3) directly interacts with and induces E3 ligase-dependent proteasomal turnover of importin α3 and α-Actinin-4 (ACTN4), which controls nuclear factor kappa B (NF-κB) activity at a well-ordered level. Read More

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December 2018

[Diagnostic significance of computed tomography findings of foreign body in esophagus].

Nihon Ronen Igakkai Zasshi 2018 ;55(4):668-674

Department of Internal Medicine II, Shimane University, Faculty of Medicine.

An 84-year-old male with dysphagia was referred to our hospital. Chest computed tomography (CT) showed a rectangular structure along with artificial air in the cervical esophagus. Endoscopy revealed a 'shogi' game piece in the same region shown in CT findings, which was recovered during the endoscopic procedure. Read More

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January 2018

Drainage Tubeless (DRESS) Bypass Surgery as the Best Palliative Care for Unresectable Thoracic Esophageal Cancer with and without Esophago-Respiratory Fistula.

Ann Thorac Cardiovasc Surg 2018 Dec 11. Epub 2018 Dec 11.

Department of Surgery, Faculty of Medicine, Miyazaki University Hospital, Miyazaki, Miyazaki, Japan.

Approximately half of the patients with esophageal cancer are diagnosed at an advanced stage with inoperable disease. The technique of bypass surgery, which is one of the palliative procedures for esophageal cancer, usually requires the insertion of a drainage tube for clearing secretions from the blind remnant esophagus. Since the artificial drainage tube is sometimes problematic for the patient after discharge from the hospital, drainage tubeless (DRESS) surgery might be preferable. Read More

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December 2018

Insulin/high-density lipoprotein cholesterol ratio: A newly-discovered predictor of esophageal varices in patients with hepatitis C virus-related cirrhosis in the absence of diabetes mellitus.

Turk J Gastroenterol 2018 Dec 12. Epub 2018 Dec 12.

Department Clinical Pathology, Al-Azhar University School of Medicine, New Damietta, Damietta, Egypt.

Background/aims: Insulin resistance (IR) is closely linked with chronic hepatitis C virus (HCV) and its complications, particularly hepatic fibrosis. The aim of the present study was to investigate some biochemical markers that are potentially related to IR as predictors of esophageal varices (EV) in patients with compensated HCV cirrhosis who do not have diabetes or metabolic syndrome.

Materials And Methods: One hundred subjects without diabetes with compensated HCV-related cirrhosis who did not fulfill the diagnostic criteria of metabolic syndrome were subjected to clinical, laboratory, ultrasonographic, and endoscopic assessments. Read More

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December 2018

Endoscopic vacuum therapy in the late diagnosed iatrogenic esophageal perforation: The convenience of using fluoroscopy.

Turk J Gastroenterol 2018 Dec 12. Epub 2018 Dec 12.

Department of Gastroenterology, Eskisehir Osmangazi University School of Medicine, Eskişehir, Turkey.

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December 2018

Single-stranded DNA binding protein 2 expression is associated with patient survival in hepatocellular carcinoma.

BMC Cancer 2018 Dec 12;18(1):1244. Epub 2018 Dec 12.

Departments of Surgery, College of Medicine, Hanyang University222 Wangsimni-ro, Seongdong-gu, Seoul, 04763, South Korea.

Background: SSBP2, single-stranded DNA binding protein 2, is a subunit of the ssDNA-binding complex that is involved in the maintenance of genome stability. The majority of previous studies have suggested a tumor-suppressive role of SSBP2, which is silenced by promoter hypermethylation in several human malignancies, such as hematologic malignancies, prostate cancer, esophageal squamous cell carcinoma, ovarian cancer, and gallbladder cancer. However, an oncogenic role of SSBP2 has been suggested in glioblastoma patients. Read More

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December 2018

What is the impact of the use of transanastomotic feeding tube on patients with esophageal atresia: a systematic review and meta-analysis.

BMC Pediatr 2018 Dec 12;18(1):385. Epub 2018 Dec 12.

Department of Pediatric Surgery, West China Hospital of Sichuan University, #37 Guo-Xue-Xiang, Chengdu, 610041, China.

Background: The transanastomotic feeding tube (TAFT) is widely used around the world in patients with esophageal atresia (EA). However, the safety of the use of TAFT is still unknown and remains to be clarified.

Methods: The following electronic databases were searched: PubMed, EMBASE and Cochrane. Read More

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December 2018

[Effect of dexmedetomidine on perioperative stress and postoperative pain in patients with radical resection of esophageal cancer under combined thoracoscope and laparoscope].

Zhonghua Yi Xue Za Zhi 2018 Dec;98(46):3778-3783

Department of Anesthesiology, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450003, China.

To investigate the effects of dexmedetomidine on perioperative stress and postoperative pain in patients with radical resection of esophageal cancer under combined thoracoscope and laparoscope. In this prospective study, one hundred patients undergoing radical resection of esophageal cancer in Affiliated Cancer Hospital of Zhengzhou University from January 2016 to October 2017, were randomly divided into control group (group C) and dexmedetomidine group (group D), =50. All patients were anaesthetized (induced and maintained) with intravenous target-controlled infusion(TCl) of propofol and remifentanil, and intermittent intravenous injection of cisatracuriumbesylate. Read More

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December 2018

Transesophageal echocardiography induced esophageal ulceration.

J Card Surg 2018 Dec 7. Epub 2018 Dec 7.

Department of Critical Care Medicine, St. John's Medical College Hospital, Bangalore, India.

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December 2018

Baseline Gastrointestinal Eosinophilia Is Common in Oral Immunotherapy Subjects With IgE-Mediated Peanut Allergy.

Front Immunol 2018 22;9:2624. Epub 2018 Nov 22.

Sean N. Parker Center for Allergy and Asthma Research, Stanford University School of Medicine, Stanford, CA, United States.

Oral immunotherapy (OIT) is an emerging treatment for food allergy. While desensitization is achieved in most subjects, many experience gastrointestinal symptoms and few develop eosinophilic gastrointestinal disease. It is unclear whether these subjects have subclinical gastrointestinal eosinophilia (GE) at baseline. Read More

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November 2018

The Impact of Goiter and Thyroid Surgery on Goiter Related Esophageal Dysfunction. A Systematic Review.

Front Endocrinol (Lausanne) 2018 20;9:679. Epub 2018 Nov 20.

Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark.

Patients with goiter referred for thyroidectomy report swallowing difficulties. This might be associated with esophageal compression and deviation as this is present in a significant number of patients. Studies on how goiter and subsequently its treatment affect the esophagus are sparse and point in various directions. Read More

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November 2018

Comorbidities are associated with different features of severe asthma.

Clin Mol Allergy 2018 3;16:25. Epub 2018 Dec 3.

1Department of Surgery, Medicine, Molecular Biology and Critical Care, University of Pisa, Pisa, Italy.

Background: According to ATS/ERS document on severe asthma (SA), the management of these patients requires the identification and proper treatment of comorbidities, which can influence the control of asthma.

Methods: The aim of this study was to assess the independent effect of different comorbidities on clinical, functional and biologic features of SA. Seventy-two patients with SA according to GINA guidelines were examined. Read More

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December 2018

Validation of non-invasive brain temperature estimation models during swine therapeutic hypothermia.

Physiol Meas 2018 Nov 14. Epub 2018 Nov 14.

Department of Biomedical Engineering, Seoul National University, Seoul, KOREA, REPUBLIC OF.

Objectives: This paper introduces a mathematical model that can estimate deep brain temperature during therapeutic hypothermia based on a double sensor method. Although the cerebral temperature is more important than the non-cerebral core temperature during therapeutic hypothermia, pulmonary artery, rectal, and esophageal measurements (i.e. Read More

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November 2018