33,879 results match your criteria Esophageal Motility Disorders


Impact of Peppermint Therapy on Dysphagia and Non-cardiac Chest Pain: A Pilot Study.

Dig Dis Sci 2019 Feb 15. Epub 2019 Feb 15.

Department of Medicine, Division of Gastroenterology and Hepatology, Medical University of South Carolina, 30 Courtenay Drive, Suite 249, MSC 702, Charleston, SC, 29425-2900, USA.

Background: Due to its smooth muscle relaxing properties, peppermint oil (PO) may relieve dysphagia and chest pain due to esophageal motility disorders.

Aim: To explore the impact of PO on dysphagia and/or chest pain in patients referred for motility testing.

Methods: Patients initiated on PO for dysphagia and/or chest pain from 2013 to 2016 were identified. Read More

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http://dx.doi.org/10.1007/s10620-019-05523-8DOI Listing
February 2019

Reflux Symptoms in Gastroparesis: Correlation With Gastroparesis Symptoms, Gastric Emptying, and Esophageal Function Testing.

J Clin Gastroenterol 2019 Feb 12. Epub 2019 Feb 12.

Section of Gastroenterology, Department of Medicine, Temple University School of Medicine, Philadelphia, PA.

Goal: The goal of this study was to determine the relationship of reflux with gastroparesis (Gp), looking both at symptoms and objective testing.

Background: Gp patients often experience gastroesophageal reflux symptoms. How the severity of reflux correlates with the severity of Gp is not known. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001190DOI Listing
February 2019

Eosinophilic esophagitis and achalasia - just a coincidence?

Z Gastroenterol 2019 Feb 12;57(2):151-155. Epub 2019 Feb 12.

Medizinische Klinik II, HELIOS Klinikum Krefeld, Germany.

Background:  Eosinophilic esophagitis (EoE) is detected frequently in dysphagia and noncardiac chest pain. Management of patients with EoE may be complicated because EoE is associated frequently with esophageal motility disorders. We present the rare case of esophageal achalasia (EA) associated with eosinophilic infiltration and a literature review. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0808-5043
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http://dx.doi.org/10.1055/a-0808-5043DOI Listing
February 2019
1 Read

Heller Myotomy for Epiphrenic Diverticula Compared to Nondiverticula Esophageal Motility Disorders, A Single Institution Experience and Appraisal of Patient Characteristics, High-Resolution Manometry and Outcomes.

Dig Surg 2019 Feb 5:1-9. Epub 2019 Feb 5.

Division of General Surgery, Morsani College of Medicine, University of South Florida, Tampa, Florida,

Purpose: The purpose of this study was to compare demographics, symptoms, prior interventions, operation, and outcomes of patients who underwent Heller myotomy for esophageal motility disorders and epiphrenic diverticulectomy with Heller myotomy.

Methods: We identified all patients who underwent Heller myotomy for esophageal motility disorders with and without esophageal diverticulectomy over an 80-month period. Primary data points included patient demographics, presenting symptoms, prior intervention, high-resolution manometry, surgery performed with rate of laparoscopic, conversion to open, and open procedures; postoperative complications, and symptom resolution. Read More

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http://dx.doi.org/10.1159/000496804DOI Listing
February 2019
1 Read

New Developments in Esophageal Motility Testing.

Curr Treat Options Gastroenterol 2019 Feb 2. Epub 2019 Feb 2.

University of Colorado Reflux & Esophageal Diseases Center, Division of Gastroenterology & Hepatology, Department of Medicine, University of Colorado, Anschutz Medical Campus, Academic Office 1 Room 7605, 12631 E. 17th Ave, Aurora, CO, 80045, USA.

Purpose Of Review: The purpose of this review is to present the latest developments in esophageal motility testing and summarize the current paradigm of esophageal motility disorders.

Recent Findings: While high-resolution esophageal pressure topography interpreted according to the Chicago Classification represents the gold standard to evaluate esophageal motility, recent studies highlight the additional value of novel manometric applications. Novel applications include provocative measures to assess for obstructive physiology at the esophagogastric junction (EGJ), esophageal peristaltic reserve, and rumination and supragastric belching disorders. Read More

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http://link.springer.com/10.1007/s11938-019-00218-5
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http://dx.doi.org/10.1007/s11938-019-00218-5DOI Listing
February 2019
8 Reads

Upright Integrated Relaxation Pressure Facilitates Characterization of Esophagogastric Junction Outflow Obstruction.

Clin Gastroenterol Hepatol 2019 Jan 29. Epub 2019 Jan 29.

Department of Medicine, Division of Gastroenterology and Hepatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

Background & Aims: Under the Chicago Classification of esophageal motility disorders, esophagogastric junction outflow obstruction (EGJOO) includes a varied clinical spectrum that results in diagnostic and management difficulties. We aimed to demonstrate that including upright swallows during high-resolution manometry (HRM) helps identify patients with clinically significant EGJOO.

Methods: We performed a retrospective study of consecutive patients diagnosed with EGJOO on HRM from January 2015 through July 2017. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15423565193007
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http://dx.doi.org/10.1016/j.cgh.2019.01.024DOI Listing
January 2019
7 Reads

High resolution manometry and new classification of esophageal motility disorders.

Ter Arkh 2018 May;90(5):93-100

Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.

Aim: To present application of Chicago classification criteria of esophageal motility disorders defined in high resolution manometry in clinical practice.

Materials And Methods: High-resolution manometry is the most exact hi-tech diagnostic method for esophageal motor function disorders according to Chicago classification v3.0. Read More

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http://dx.doi.org/10.26442/terarkh201890593-100DOI Listing
May 2018
4 Reads

Esophagogastric junction outflow obstruction: Where are we now in diagnosis and management?

World J Gastroenterol 2019 Jan;25(4):411-417

Department of Medicine, Division of Digestive Diseases, Emory University School of Medicine, Atlanta, GA 30322, United States.

Esophagogastric junction outflow obstruction (EGJOO) is a major motility disorder based on the Chicago Classification of esophageal motility disorders. This entity involves a heterogenous group of underlying etiologies. The diagnosis is reached by performing high-resolution manometry. Read More

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http://dx.doi.org/10.3748/wjg.v25.i4.411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350167PMC
January 2019
1 Read

Advances in the Diagnosis and Treatment of GERD: New Tricks for an Old Disease.

Curr Treat Options Gastroenterol 2019 Jan 25. Epub 2019 Jan 25.

Division of Gastroenterology, Hepatology, and Nutrition, Center for Swallowing and Esophageal Disorders, Digestive Disease Center, Vanderbilt University Medical Center, 1660 TVC, Nashville, TN, 37232-5280, USA.

Purpose Of Review: Gastroesophageal reflux disease (GERD) is a common diagnosis encountered by both primary care providers and specialists, but despite its prevalence, there are limitations in the current diagnostic tests for GERD. Once an accurate diagnosis is made, treatment options can be offered, and this field continues to burgeon with options. In this review, we seek to review the recent advances in GERD diagnostics and subsequent treatment options. Read More

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http://dx.doi.org/10.1007/s11938-019-00213-wDOI Listing
January 2019
14 Reads

Melatonin for the treatment of gastroesophageal reflux disease; protocol for a systematic review and meta-analysis.

Medicine (Baltimore) 2019 Jan;98(4):e14241

Background: Melatonin generated in the gastrointestinal tract has mucosal protective effect with inhibiting gastric acid secretion, while increasing gastrin release, which in turn stimulates the contractility of lower esophageal sphincter. Gastroesophageal reflux disease (GERD) is also known to have association with sleep disturbance. However, melatonin or melatonin receptor agonist has not been included in the treatment of GERD. Read More

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http://Insights.ovid.com/crossref?an=00005792-201901250-0006
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http://dx.doi.org/10.1097/MD.0000000000014241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358381PMC
January 2019
5 Reads
5.723 Impact Factor

Association between tea consumption and gastroesophageal reflux disease: A meta-analysis.

Medicine (Baltimore) 2019 Jan;98(4):e14173

Department of Proctology, Jining No.1 People's Hospital, Jining, Shandong, China.

Background: Gastroesophageal reflux disease (GERD) is one of the most common digestive system diseases, which is associated with lifestyle and dietary factors. The main mechanism involved in GERD is affected by demographics, lifestyles, and dietary factors. Tea consumption is reported to be associated with GERD, especially in Asian population. Read More

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http://Insights.ovid.com/crossref?an=00005792-201901250-0003
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http://dx.doi.org/10.1097/MD.0000000000014173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358326PMC
January 2019
5 Reads

Megaesophagus in a Patient with Achalasia.

GE Port J Gastroenterol 2018 Dec 13;26(1):75-77. Epub 2018 Mar 13.

Gastroenterology Department, Amato Lusitano Hospital, Castelo Branco, Portugal.

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http://dx.doi.org/10.1159/000487276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341370PMC
December 2018
1 Read

Superior mesenteric artery syndrome coexists with Nutcracker syndrome in a female: a case report.

BMC Gastroenterol 2019 Jan 23;19(1):15. Epub 2019 Jan 23.

Department of Gastroenterology, The First Affiliated Hospital, Jinan University, Guangzhou, 510630, People's Republic of China.

Background: Superior mesenteric artery (SMA) syndrome, also known as Wilkie's syndrome or Benign duodenal stasis, is a rare benign disease. It could threaten the life if the manifestation is severe and the treatment is inappropriate. In the patients with SMA syndrome, the third portion (transverse part) of the duodenum is compressed externally between the SMA and abdominal aorta (AA) leading to duodenal stasis and gastrointestinal obstruction. Read More

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https://bmcgastroenterol.biomedcentral.com/articles/10.1186/
Publisher Site
http://dx.doi.org/10.1186/s12876-019-0932-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343343PMC
January 2019
3 Reads

Reimbursement for endoscopic innovations: the final hurdle.

Gastrointest Endosc 2019 02;89(2):274-276

Predictive Health, University of Arizona College of Medicine - Phoenix, Phoenix, Arizona, USA.

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http://dx.doi.org/10.1016/j.gie.2018.09.022DOI Listing
February 2019
1 Read
5.369 Impact Factor

Is EndoFLIP Useful for Predicting Clinical Outcomes after Peroral Endoscopic Myotomy in Patients with Achalasia?

Authors:
Gwang Ha Kim

Gut Liver 2019 01;13(1):3-4

Department of Internal Medicine, Pusan National University School of Medicine, and Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.

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http://dx.doi.org/10.5009/gnl18443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347008PMC
January 2019
2 Reads

Importance of Barium Swallow Test and Chest CT Scan for Correct Diagnosis of Achalasia in the Primary Care Setting.

Tohoku J Exp Med 2019 ;247(1):41-49

Division of Gastroenterology and Hepatobiliary Pancreatic Surgery, Tohoku Medical and Pharmaceutical University.

Esophageal achalasia is a disease characterized by the impaired esophageal peristalsis and non-relaxation of the lower esophageal sphincter muscle with unknown causes. Clinical manifestation of the disease is nonspecific (e.g. Read More

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https://www.jstage.jst.go.jp/article/tjem/247/1/247_41/_arti
Publisher Site
http://dx.doi.org/10.1620/tjem.247.41DOI Listing
February 2019
7 Reads

Etiology analysis of nonspecific chronic cough in children of 5 years and younger.

Medicine (Baltimore) 2019 Jan;98(3):e13910

This study aims to analyze the etiology of nonspecific chronic cough in children of 5 years and younger, in order to improve the diagnostic and treatment levels of pediatricians for nonspecific chronic cough in young children.The clinical data of 85 cases of children of 5 years old and below, who suffered from nonspecific chronic cough between the period of January 2015 and August 2016 were retrospectively analyzed.The etiology distribution of 85 cases of children with nonspecific chronic cough were as follows: 27 cases had cough variant asthma (31. Read More

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http://dx.doi.org/10.1097/MD.0000000000013910DOI Listing
January 2019
9 Reads

Assessment of Esophageal Motor Disorders Using High-resolution Manometry in Esophageal Dysphagia With Normal Endoscopy.

J Neurogastroenterol Motil 2019 Jan;25(1):61-67

Department of Gastroenterology, the First Hospital of Jilin University, China.

Background/aims: The distribution and esophageal motor characteristics of Chinese patients with esophageal dysphagia who exhibit no structural abnormalities on esophagogastroduodenoscopy remain unclear. Our aim is to assess the esophageal motor patterns using high-resolution manometry (HRM) and classify them according to the Chicago classification version 3.0 (CC v3. Read More

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http://www.jnmjournal.org/journal/view.html?doi=10.5056/jnm1
Publisher Site
http://dx.doi.org/10.5056/jnm18042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326201PMC
January 2019
5 Reads

Proton Pump Inhibitor Ameliorates Taste Disturbance among Patients with Laryngopharyngeal Reflux: A Randomized Controlled Study.

Tohoku J Exp Med 2019 01;247(1):19-25

Department of Otorhinolaryngology, Nagoya City University.

Patients with laryngopharyngeal reflux (LPR) were reported to suffer from hypogeusia that affects quality of life. Proton pump inhibitor (PPI) is a useful drug in the treatment of LPR, but its effect on hypogeusia is not known. We therefore assessed the effects of PPI or a histamine H2 receptor antagonist (H2 blocker) on hypogeusia among patients with LPR. Read More

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http://dx.doi.org/10.1620/tjem.247.19DOI Listing
January 2019
1 Read

Etiologies and clinical characteristics of non-obstructive dysphagia in a Taiwanese population: A prospective study based on high-resolution impedance manometry.

J Formos Med Assoc 2019 Jan 8. Epub 2019 Jan 8.

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

Background: Esophageal motility disorders are the major cause of non-obstructive dysphagia (NOD), but may be underdiagnosed. In this high-resolution impedance manometry (HRIM)-based study, we aimed to clarify the etiologies and clinical characteristics of patients presenting with NOD in a Taiwanese population.

Methods: From October 2014 to July 2017, consecutive patients with the chief complaint of dysphagia were prospectively enrolled in the study at a tertiary medical center. Read More

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http://dx.doi.org/10.1016/j.jfma.2018.12.019DOI Listing
January 2019
1 Read

Correlation Between Clinical Signs and High-Resolution Manometry Data in Children.

J Pediatr Gastroenterol Nutr 2019 Jan 4. Epub 2019 Jan 4.

Department of Gastroenterology, North Hospital, Assistance Publique - Hôpitaux de Marseille, Marseille, France.

Objectives: High-resolution manometry (HRM) is the gold standard for diagnosis of esophageal motility disorders. However, clinical signs associated with these disorders are non-specific, and it is difficult to correlate clinical signs with HRM data. The main objective of our study was to assess the positive predictive value (PPV) and negative predictive value (NPV) of each clinical sign, as well as their sensitivity and specificity in the diagnosis of esophageal motility disorders. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002232DOI Listing
January 2019
1 Read

Multiple rapid swallow testing in patients with gastroesophageal reflux disease.

Indian J Gastroenterol 2018 Nov 7;37(6):555-558. Epub 2019 Jan 7.

Department of Gastroenterology, Gleneagles Global Health City, 439, Cheran Nagar, Chennai, 600 100, India.

Patients with gastroesophageal reflux disease are commonly referred to a gastrointestinal motility unit for assessment of esophageal physiology tests prior to an anti-reflux procedure. On esophageal manometry, most patients have normal peristalsis; however, minor disorders of motility such as ineffective esophageal motility and fragmented peristalsis are not uncommon. Multiple rapid swallow (MRS) test is a provocative method for assessing peristaltic reserve in such patients. Read More

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http://dx.doi.org/10.1007/s12664-018-0919-9DOI Listing
November 2018
1 Read

Robotic Fundoplication for Gastroesophageal Reflux Disease and Hiatal Hernia: Initial Experience and Outcome.

Am Surg 2018 Dec;84(12):1945-1950

Gastroesophageal reflux disease, associated with sliding or large paraesophageal hiatal hernia, represents a common clinical presentation. The repair of large paraesophageal hiatal hernias is still a challenge in minimally invasive surgery. Between March 2014 and August 2016, 50 patients (18 males and 32 females) underwent robotic fundoplication (17 sliding and 33 paraesophageal hernias). Read More

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December 2018
2 Reads

The 2 years' long-term efficacy and safety of peroral endoscopic myotomy for the treatment of achalasia: a systematic review.

J Cardiothorac Surg 2019 Jan 3;14(1). Epub 2019 Jan 3.

Department of Gastroenterology, Affliated Hospital of Southwest Medical University, Street Taiping No.25, Region Jiangyang, Luzhou, 646099, Sichuan Province, China.

Aim: In this retrospective review, we aimed to investigate the long-term efficacy and safety of POEM with follow-up period over 2 years.

Materials And Methods: A systematic review related to POEM for achalasia was conducted. A literature search was performed in Pubmed, Medline, Ovid, Cochrane and EBSCO databases on November 2017. Read More

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http://dx.doi.org/10.1186/s13019-018-0811-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318943PMC
January 2019
2 Reads

Pepsin in Saliva as a Diagnostic Marker for Gastroesophageal Reflux Disease: A Meta-Analysis.

Med Sci Monit 2018 Dec 31;24:9509-9516. Epub 2018 Dec 31.

Department of Gastroenterology, Beijing Tong Ren Hospital, Capital Medical University, Beijing, China (mainland).

BACKGROUND Gastroesophageal reflux disease (GERD) is very common. Salivary pepsin detection has previously been considered as a method for GERD diagnosis. We performed a meta-analysis to investigate the utility of salivary pepsin assay as a diagnostic tool of GERD. Read More

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https://www.medscimonit.com/abstract/index/idArt/913978
Publisher Site
http://dx.doi.org/10.12659/MSM.913978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324865PMC
December 2018
11 Reads

Practice styles, knowledge and attitudes of general practitioners and gastroenterology specialists who treat gastroesophageal reflux disease.

Medicine (Baltimore) 2018 Dec;97(52):e13781

Division of Gastroenterology, Rabin Medical Center, Beilinson Hospital.

As little is known on the subject, our aim was to compare practice styles, knowledge and attitudes of general practitioners (GPs), and gastroenterology specialists (GIs) regarding the treatment of gastroesophageal reflux disease (GERD).An internet survey designed by the authors was sent nationwide and randomly to 290 GIs and 1312 GPs. We assessed for the burden of GERD, indications for referral for a GI consultation, criteria for proton pump inhibitors (PPIs) selection, and main unmet treatment needs. Read More

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http://dx.doi.org/10.1097/MD.0000000000013781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314753PMC
December 2018
2 Reads

Increased risk of appendectomy in patients with gastroesophageal reflux disease: A nested case-control study using a national sample cohort.

Medicine (Baltimore) 2018 Dec;97(52):e13700

Department of Otorhinolaryngology-Head & Neck Surgery, Hallym University College of Medicine.

The purpose of this study is to confirm and complement previous data regarding an association between gastroesophageal reflux disease and appendectomy.The Korean National Health Insurance Service-National Sample Cohort includes data from people ≥ 20 years old collected from 2002 to 2013. A total of 13,484 participants who received an appendectomy were matched with 53,936 controls at a 1:4 ratio. Read More

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http://dx.doi.org/10.1097/MD.0000000000013700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314750PMC
December 2018
1 Read

Lower Esophageal Sphincter-preserving Anastomosis Is an Acceptable Reconstruction Method Following Laparoscopy-assisted Proximal Gastrectomy.

Anticancer Res 2019 Jan;39(1):425-430

Department of Surgery; Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea

Background/aims: Our study aimed to compared 3-year results following laparoscopy-assisted proximal gastrectomy (LAPG)-double tract anastomosis (DTA) and lower esophageal sphincter-preserving LAPG (LES-LAPG).

Patients And Methods: Nine patients who underwent LES-LAPG and 23 LAPG-DTA were compared regarding 3-year follow-up complications, the anemia-related parameter and albumin levels.

Results: During the 3-year follow-up period, no patient (0%) in the LES-LAPG and six patients (6/23, 26. Read More

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http://dx.doi.org/10.21873/anticanres.13129DOI Listing
January 2019
3 Reads

Pilot Study of Pharyngoesophageal Dysmotility Mechanisms in Dysphagic Infants of Diabetic Mothers.

Am J Perinatol 2018 Dec 21. Epub 2018 Dec 21.

Division of Neonatology, Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, Ohio.

Objective:  Swallowing difficulties are common in infants of diabetic mothers (IDM) and mechanisms are unclear. We tested the hypothesis that pharyngoesophageal motility reflexes are distinct in IDMs compared with healthy controls in a pilot study.

Study Design:  Basal and adaptive pharyngoesophageal motility characteristics of 20 dysphagic IDMs and 10 controls were studied using purpose-built micromanometry system. Read More

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http://dx.doi.org/10.1055/s-0038-1676632DOI Listing
December 2018
2 Reads
1.597 Impact Factor

A Case of Diffuse Esophageal Spasm Treated with Peroral Endoscopic Myotomy.

Acta Med Okayama 2018 Dec;72(6):595-600

Department of Gastroenterology and Hepatology, Okayama University Hospital, Okayama 700-8558,

The indications for peroral endoscopic myotomy (POEM) have been expanded to include diffuse esophageal spasm (DES). A 67-year-old Japanese man presented with a 4-year history of dysphagia. Endoscopy and upper gastrography revealed abnormal peristaltic movements involving interruption of normal peristalsis, and a diverticulum located at the 2 o'clock esophageal position. Read More

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http://dx.doi.org/10.18926/AMO/56378DOI Listing
December 2018
12 Reads

Refractory regurgitation responds to magnetic sphincter augmentation but not to increased proton pump inhibitor dose.

Gastrointest Endosc 2019 01;89(1):23-24

Division of Gastroenterology, Mayo Clinic Jacksonville, Jacksonville, Florida, USA.

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http://dx.doi.org/10.1016/j.gie.2018.10.040DOI Listing
January 2019
1 Read

Pulmonary aspiration in preschool children with cystic fibrosis.

Respir Res 2018 Dec 17;19(1):255. Epub 2018 Dec 17.

National Children's Research Centre, Crumlin, Dublin 12, Ireland.

Pulmonary aspiration of gastric refluxate (PAGR) has been demonstrated in association with pulmonary inflammation in school aged children with Cystic Fibrosis (CF). We sought to determine if similar findings were present in preschool children. Pepsin was measured in Broncho-alveolar lavage (BAL) fluid collected from clinically stable preschool children with CF and controls. Read More

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http://dx.doi.org/10.1186/s12931-018-0954-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296125PMC
December 2018
1 Read

Primary gastric inflammatory myofibroblastic tumor: A case report.

Medicine (Baltimore) 2018 Dec;97(50):e13423

Department of Radiology, The First Affiliated Hospital, Nanchang University, Nanchang, Jiangxi, People's Republic of China.

Rationale: Primary gastric inflammatory myofibroblastic tumor is extremely rare. Only a few cases were reported in the domestic and foreign medical literature with corresponding imaging findings of this disease even more rarely reported.

Patient Concerns: We present one case of a 52-year-old female patient with upper abdominal pain, acid reflux, and belching for 2 months. Read More

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http://dx.doi.org/10.1097/MD.0000000000013423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320093PMC
December 2018
1 Read
5.723 Impact Factor

Small hepatocellular carcinoma suppressed by chemotherapy for synchronous gastric carcinoma after laparoscopy-assisted radical distal gastrectomy: A case report and literature review.

Medicine (Baltimore) 2018 Dec;97(50):e13190

Hepatic Surgery Center, Department of Surgery, Tongji Hospital of Tongji Medical College.

Rationale: Synchronous gastric carcinoma and hepatocellular carcinoma (HCC) is rare. It is hard to distinguish synchronous HCC from metastatic liver cancer in this condition. The treatment and prognosis is quite different for synchronous HCC of gastric carcinoma and liver metastasis of gastric carcinoma. Read More

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http://dx.doi.org/10.1097/MD.0000000000013190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319982PMC
December 2018
4 Reads

Pharyngoesophageal and cardiorespiratory interactions: potential implications for premature infants at risk of clinically significant cardiorespiratory events.

Am J Physiol Gastrointest Liver Physiol 2019 Feb 13;316(2):G304-G312. Epub 2018 Dec 13.

Innovative Neonatal and Infant Feeding Disorders Research Program, Center for Perinatal Research, The Research Institute at Nationwide Children's Hospital , Columbus, Ohio.

The aims of this study were to 1) examine pharyngoesophageal and cardiorespiratory responses to provoking pharyngeal stimuli, and 2) to determine potential contributory factors impacting heart rate (HR) changes to provide insight into cardiorespiratory events occurring in preterm infants. Forty-eight neonates (19 females and 29 males, born at 27.7 ± 0. Read More

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http://dx.doi.org/10.1152/ajpgi.00303.2018DOI Listing
February 2019
2 Reads
3.798 Impact Factor

THE EFFICACY OF THE DIFFERENT ENDOSCOPIC TREATMENTS VERSUS SHAM, PHARMACOLOGIC OR SURGICAL METHODS FOR CHRONIC GASTROESOPHAGEAL REFLUX DISEASE: A SYSTEMATIC REVIEW AND META-ANALYSIS.

Arq Gastroenterol 2018 Jul-Sep;55(3):296-305

Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Departamento de Endoscopia Avançada Gastrointestinal, São Paulo, SP, Brasil.

Background: Endoscopic antireflux treatments for gastroesophageal reflux disease (GERD) are still evolving, and most of the published studies address symptom relief in the short-term. Objective - We aimed to perform a systematic review and meta-analysis focused on evaluating the efficacy of the different endoscopic procedures.

Methods: Search was restricted to randomized controlled trials (RCTs) on MedLine, Cochrane, SciELO, and EMBASE for patients with chronic GERD (>6 months), over 18 years old and available follow up of at least 3 months. Read More

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http://dx.doi.org/10.1590/S0004-2803.201800000-65DOI Listing
January 2019

Esophageal transit scintigraphy in children: a user's guide and pictorial review.

Pediatr Radiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Radiology, Harvard Medical School, Boston Children's Hospital, 300 Longwood Ave., Boston, MA, 02115, USA.

Technical and clinical aspects of esophageal transit scintigraphy in pediatric patients are reviewed via several illustrative cases that highlight its utility in evaluating primary and secondary esophageal motility disorders. Read More

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http://dx.doi.org/10.1007/s00247-018-4301-yDOI Listing
December 2018
1 Read

Ineffective Esophageal Motility Is Associated with Impaired Bolus Clearance but Does Not Correlate with Severity of Dysphagia.

Dig Dis Sci 2018 Dec 10. Epub 2018 Dec 10.

Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, 161 Fort Washington Avenue, Suite 862, New York, NY, 10032, USA.

Background: Ineffective esophageal motility (IEM) is defined as a distal contractile integral < 450 mmHg/s/cm in at least 50% of ten liquid swallows on high-resolution esophageal manometry (HREM). Whether this latest definition correlates with degree of symptoms has not been studied.

Methods: Patients presenting for HREM prospectively rated their symptoms using the Eckardt score. Read More

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http://dx.doi.org/10.1007/s10620-018-5384-xDOI Listing
December 2018
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SHORT-TERM RESULTS OF MINIMALLY INVASIVE TREATMENT OF GASTROESOPHAGEAL REFLUX DISEASE BY RADIOFREQUENCY (STRETTA): FIRST BRAZILIAN SERIES OF CASES.

Arq Gastroenterol 2018 Nov;55Suppl 1(Suppl 1):52-55

Instituto Endovitta, São Paulo, SP, Brasil.

Background: New endoscopic treatments for gastroesophageal reflux (GERD) are developed every year and are indicated in cases that are refractory to conventional therapies as well as after surgical treatment failure.

Objective: To present the first cases of endoscopic therapy for GERD performed in Brazil.

Methods: Use of radiofrequency with the Stretta procedure in symptomatic volunteers diagnosed with GERD. Read More

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http://dx.doi.org/10.1590/S0004-2803.201800000-51DOI Listing
November 2018
2 Reads

Recent advances in TMEM16A: Structure, function, and disease.

J Cell Physiol 2018 Dec 4. Epub 2018 Dec 4.

Key Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Sciences, Hebei University of Technology, Tianjin, China.

TMEM16A (also known as anoctamin 1, ANO1) is the molecular basis of the calcium-activated chloride channels, with ten transmembrane segments. Recently, atomic structures of the transmembrane domains of mouse TMEM16A (mTMEM16A) were determined by single-particle electron cryomicroscopy. This gives us a solid ground to discuss the electrophysiological properties and functions of TMEM16A. Read More

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http://dx.doi.org/10.1002/jcp.27865DOI Listing
December 2018
3 Reads

Involvement of the TLR4/NF-κB Signaling Pathway in the Repair of Esophageal Mucosa Injury in Rats with Gastroesophageal Reflux Disease.

Cell Physiol Biochem 2018 29;51(4):1645-1657. Epub 2018 Nov 29.

Background/aims: Numerous studies have highlighted the activation of NF-κB in the esophageal mucosa during the early stages of gastroesophageal reflux disease (GERD). The present study aimed to investigate the role of the TLR4/NF-κB signaling pathway in GERD rat models.

Methods: Wistar rats (n = 60) were recruited to establish a GERD animal model. Read More

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http://dx.doi.org/10.1159/000495652DOI Listing
January 2019
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Comparative Study of Alginate and Omeprazole in Symptomatic Treatment of Non-erosive Gastroesophageal Reflux Disease.

Mymensingh Med J 2018 Oct;27(4):771-775

Dr ANM Saifullah, Assistant Professor, Department of Gastroenterology, Sir Salimullah Medical College (SSMC), Dhaka, Bangladesh; E-mail: saifullahanm

Gastroesophageal reflux disease is widely reported most prevalent disease of the gastrointestinal tract. The burden of gastroesophageal reflux disease (GERD) is increasing in Asia and the majority of patients have non-erosive reflux disease. This prospective, open label, non random (consecutive), experimental study was performed due to compare the therapeutic efficacy of alginate and omeprazole in relieving symptoms of non erosive reflux disease (NERD) and was carried out in the Outpatient Department of Gastroenterology, Dhaka Medical College Hospital, Dhaka, Bangladesh from December 2013 to May 2014. Read More

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October 2018
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[Esophageal motility and reflux characteristics in gastroesophageal reflux disease patients with or without extra-esophageal symptoms].

Zhonghua Yi Xue Za Zhi 2018 Nov;98(44):3579-3583

Department of Gastroenterology, China-Japan Friendship Hospital, Beijing 100029, China.

To investigate esophageal motility and reflux characteristics in gastroesophageal reflux disease (GERD) with and without extra-esophageal symptoms by high-resolution manometry and 24 h esophageal multichannel intraluminal impedance combined pH (MII-pH) monitoring. From February 2016 to June 2017, GERD patients with and without extra-esophageal symptoms were enrolled in this prospective controlled study. Esophageal HRM and 24 h MII-pH monitoring were performed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2018.44.006DOI Listing
November 2018
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Proton Pump Inhibitor-Refractory Gastroesophageal Reflux Disease.

Med Clin North Am 2019 Jan 1;103(1):15-27. Epub 2018 Nov 1.

Division of Gastroenterology and Hepatology, University of Colorado Anschutz Medical Campus, 12631 East 17th Avenue B158, Aurora, CO 80045, USA.

Proton pump inhibitor (PPI)-refractory gastroesophageal reflux disease (GERD) is defined by the presence of troublesome GERD symptoms despite PPI optimization for at least 8 weeks in the setting of ongoing documented pathologic gastroesophageal reflux. It arises from a dysfunction in protective systems to prevent reflux and as propagation of physiologic reflux events. Treatment possibilities include pharmacologic options, invasive management strategies, and endoluminal therapies. Read More

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http://dx.doi.org/10.1016/j.mcna.2018.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260943PMC
January 2019
1 Read

Proton Pump Inhibitors: What the Internist Needs to Know.

Med Clin North Am 2019 Jan 23;103(1):1-14. Epub 2018 Oct 23.

Division of Gastroenterology, Center for Esophageal Diseases, Baylor University Medical Center, Center for Esophageal Research, Baylor Scott & White Research Institute, 3500 Gaston Avenue, 2 Hoblitzelle, Suite 250, Dallas, TX 75246, USA. Electronic address:

This report reviews the physiology of gastric acid suppression by proton pump inhibitors (PPIs) and anti-inflammatory effects of PPIs that are independent of their acid-suppressive effects. Valid indications for PPI use are discussed, as are putative adverse effects of PPIs that have been identified through weak associations in observational studies that cannot establish cause-and-effect relationships. Although evidence supporting the validity of these adverse effects is weak, there is also insufficient evidence to dismiss the risks. Read More

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http://dx.doi.org/10.1016/j.mcna.2018.08.001DOI Listing
January 2019
9 Reads

Weight Management as a Treatment Option for Gastroesophageal Reflux Disease: A Mechanical or Metabolic Rescuer?

Authors:
Hyuk Lee

Gut Liver 2018 11;12(6):607-608

Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

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http://dx.doi.org/10.5009/gnl18451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254623PMC
November 2018
1 Read

Na /Ca exchanger 1 is a key mechanosensitive molecule of the esophageal myenteric neurons.

Acta Physiol (Oxf) 2018 Nov 22:e13223. Epub 2018 Nov 22.

Department of Medicine, University of California, San Diego, California.

Aim: Our earlier studies showed that mechanical stretch activates inhibitory motor neurons of the oesophagus; however, the underlying molecular mechanisms are unclear. Here, we sought to examine if Na /Ca exchanger 1 (NCX1) is responsible for the mechanosensitivity in the esophageal myenteric neurons (EMN) of rats and humans.

Methods: The function of NCX1 in primary culture of neurons was determined using calcium imaging, and mechanosensitivity was tested using osmotic stretch and direct mechanical stretch. Read More

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http://dx.doi.org/10.1111/apha.13223DOI Listing
November 2018
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A Distinct Esophageal mRNA Pattern Identifies Eosinophilic Esophagitis Patients With Food Impactions.

Front Immunol 2018 5;9:2059. Epub 2018 Nov 5.

Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA, United States.

Eosinophilic esophagitis (EoE), a Th2-type allergic immune disorder characterized by an eosinophil-rich esophageal immune infiltrate, is often associated with food impaction (FI) in pediatric patients but the molecular mechanisms underlying the development of this complication are not well understood. We aim to identify molecular pathways involved in the development of FI. Due to large variations in disease presentation, our analysis was further geared to find markers capable of distinguishing EoE patients that are prone to develop food impactions and thus expand an established medical algorithm for EoE by developing a secondary analysis that allows for the identification of patients with food impactions as a distinct patient population. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02059
Publisher Site
http://dx.doi.org/10.3389/fimmu.2018.02059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230678PMC
November 2018
14 Reads

[Interpretation und performance of high-resolution esophageal manometry: Recommendations of the German Association of Neurogastroenterology and Motility (DGNM) and the German Association of Gastroenterology, Digestive and Metabolic Diseases (DGVS)].

Z Gastroenterol 2018 Nov 12;56(11):1378-1408. Epub 2018 Nov 12.

Medizinische Klinik und Poliklinik II, LMU, Campus Großhadern, München.

Esophageal manometry provides a detailed evaluation of esophageal contractility and, therefore, represents the reference method for diagnosis of esophageal motility disorders. Significance and clinical relevance have been further increased by implementation of high-resolution esophageal manometry (HRM), which reveals the functional anatomy of the esophagus in a visually-intuitive manner. The current 3 rd version of the international Chicago Classification (CC v3. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0713-0944
Publisher Site
http://dx.doi.org/10.1055/a-0713-0944DOI Listing
November 2018
3 Reads