38,043 results match your criteria Esophageal Motility Disorders

Towards a more precise classification of esophageal motility disorders in patients with systemic sclerosis.

Neurogastroenterol Motil 2022 May 20:e14416. Epub 2022 May 20.

Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy.

Systemic sclerosis (SSc) is a chronic and generalized disease affecting the connective tissue of the skin and many internal organs, in particular the gastrointestinal tract. The esophagus is involved in up to 80% of the cases and represents a major cause of serious morbidities that deeply impact on the quality of life and survival of patients. Indeed, the presence of esophageal dysfunction is a good prognostic indicator in SSc, primarily due to its impact on pulmonary disease. Read More

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The true prevalence of cervical inlet patch in a specific center dealing with esophageal diseases.

T Akar S Aydın

Eur Rev Med Pharmacol Sci 2022 May;26(9):3127-3131

Department of Gastroenterology, Advanced Endoscopic Procedures Unit, Hisar Intercontinental Hospital, Galata University, Galata, Turkey.

Objective: Cervical Inlet Patch (CIP) is an interesting entity that is little known and often neglected by endoscopists. It has always been reported as less than expected. In this article, for the first time in the literature, we want to measure the true prevalence of CIP in a center dealing with specific esophageal diseases. Read More

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Comparison of fully coated anti-reflux metal stenting and per-oral endoscopic myotomy in patients with achalasia: a propensity score-matched retrospective study.

BMC Gastroenterol 2022 May 18;22(1):253. Epub 2022 May 18.

Department of Gastroenterology, The Seventh Medical Center of PLA General Hospital, Nanmencang 5#, Dongcheng District, Beijing, 100700, China.

Background: Achalasia is a rare primary esophageal motility disorder disease. It is reported that the long-term effect of fully coated anti-reflux metal stent (FCARMS) implantation is satisfactory. Operated by a skilled and experienced endoscopist, the effect of per-oral endoscopic myotomy (POEM) treatment is equivalent to that of surgical myotomy. Read More

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Global, regional and national burden of gastroesophageal reflux disease, 1990-2019: update from the GBD 2019 study.

Ann Med 2022 Dec;54(1):1372-1384

Department of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha, China.

Background: Because trends in the epidemiology and burden of gastroesophageal reflux disease (GERD) are changing, reinvestigating the geographical differences and trend changes is essential. Here we evaluated the latest epidemiologic patterns and trends for GERD, using data from Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019.

Methods: Annual case numbers, age-standardized rates of prevalence, incidence, and years of life lived with disability (YLDs), and their estimated annual percentage changes (EAPCs) for GERD between 1990 and 2019 were derived from the GBD 2019 study. Read More

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December 2022

Congenital true oesophageal diverticulum: a report and review of the literature.

BMJ Case Rep 2022 May 16;15(5). Epub 2022 May 16.

Department of Paediatric Surgery, All India Institute of Medical Sciences, New Delhi, Delhi, India.

Oesophageal diverticulum occurring secondary to motility disorders or gastro-oesophageal reflux disease (GERD) is common in adults but true congenital oesophageal diverticula are rare in infants and children. We present a case of a toddler boy who presented with dysphagia and vomiting after feeds after weaning was attempted starting at 6 months of age. Barium esophagogram revealed a diverticulum in the upper one-third of the oesophagus within the thoracic cavity. Read More

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Risks of refractory chest pain after peroral endoscopic myotomy in achalasia-related esophageal motility disorders: short-term results from a multicenter study in Japan.

Gastrointest Endosc 2022 May 11. Epub 2022 May 11.

Digestive Diseases Center, Showa University Koto-Toyosu Hospital, Tokyo.

Background And Aims: The etiology of chest pain in achalasia-related esophageal motility disorders (AEMDs) and the frequency and risk factors of persistent chest pain after peroral endoscopic myotomy (POEM) remain unclear.

Methods: A multicenter cohort study including 14 hospitals was conducted to elucidate the characteristics of patients with chest pain and the efficacy of POEM.

Results: Consecutive cases of AEMDs included 2,294 (64. Read More

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The Effect of Fermentable, Oligosaccharides, Disaccharides, Monosaccharides, and Polyols (FODMAP) Meals on Transient Lower Esophageal Relaxations (TLESR) in Gastroesophageal Reflux Disease (GERD) Patients with Overlapping Irritable Bowel Syndrome (IBS).

Nutrients 2022 Apr 22;14(9). Epub 2022 Apr 22.

Division of Gastroenterology, Department of Medicine, King Chulalongkorn Memorial Hospital, The Thai Red Cross Society, Bangkok 10330, Thailand.

A randomized crossover study in eight patients (6 F, age 57 ± 13) with overlapping GERD-IBS (non-constipation) was conducted to evaluate the effects of rice noodle vs. wheat noodle meals for breakfast and lunch on postprandial TLESR, intestinal gas production, and GERD/GI symptoms. Results: Wheat ingestion was significantly associated with more frequent TLESR after lunch than rice (5. Read More

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Expression of VEGF, EGF, and Their Receptors in Squamous Esophageal Mucosa, with Correlations to Histological Findings and Endoscopic Minimal Changes, in Patients with Different GERD Phenotypes.

Int J Environ Res Public Health 2022 Apr 27;19(9). Epub 2022 Apr 27.

Department of Gastroenterology and Internal Medicine, Medical University of Bialystok, 15-276 Bialystok, Poland.

Background: Gastroesophageal reflux disease (GERD) may present as nonerosive reflux disease (NERD), erosive esophagitis (EE), or be complicated by Barrett's esophagus (BE). The explanation as to what determines the phenotype of GERD is awaited. Therefore, we assessed the correlation between the growth factors expression and endoscopic as histologic findings in GERD patients. Read More

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Relationship Between Esophageal Motility Disorders and Autonomic Nervous System in Diabetic Patients: Pilot North African Study.

Am J Mens Health 2022 May-Jun;16(3):15579883221098588

Laboratory of Physiology, Faculty of Medicine of Sousse, University of Sousse, Sousse, Tunisia.

Little attention has been given to esophageal disorders in diabetes mellitus. Pathophysiology of esophageal motility disorders (EMD) in patients with diabetes mellitus is multifactorial. The aims of the present study were: (a) to evaluate the prevalence of EMD in patients with Type 2 diabetes mellitus and (b) to determine the relationship between EMD and autonomic neuropathy as assessed by heart rate variability (HRV). Read More

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Supragastric belching: Pathogenesis, diagnostic issues and treatment.

Saudi J Gastroenterol 2022 May-Jun;28(3):168-174

Department of Anatomy, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Belching is defined as an audible escape of air from the esophagus or the stomach into the pharynx. It becomes pathologic if it is excessive and becomes bothersome. According to Rome IV diagnostic criteria, there is a belching disorder when one experiences bothersome belching (severe enough to impact on usual activities) more than 3 days a week. Read More

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Frequently reported adverse events of rebamipide compared to other drugs for peptic ulcer and gastroesophageal reflux disease.

Sci Rep 2022 May 12;12(1):7839. Epub 2022 May 12.

College of Pharmacy, Ewha Womans University, Seoul, 03760, Republic of Korea.

This study aimed to detect safety signals of rebamipide and search for adverse events (AEs) of rebamipide that are more common than those of other drugs for peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD) in the elderly population. A total of 101,735 AE reports for drugs used to treat PUD and GERD between 2009 and 2018 from the KIDS-KAERS database (KIDS-KD) were used. Disproportionality analysis was performed to calculate the proportional reporting ratio (PRR), reporting odds ratio (ROR), and information component (IC). Read More

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Analysis of Esophageal Motility and Reflux Characteristics in Patients with Gastroesophageal Reflux Disease With or Without Extraesophageal Symptoms.

Turk J Gastroenterol 2022 Apr;33(4):280-285

Department of Digestion, Zhejiang Hospital, Hangzhou, China.

Background: The pathogenesis of extraesophageal symptoms of gastroesophageal reflux disease is complex, and esophageal motility and reflux may be involved in it. In this study, we aimed to compare esophageal motility and reflux characteristics in gastroesopha- geal reflux disease patients with and without extraesophageal symptoms by high-resolution manometry and multichannel intraluminal impedance-pH monitoring.

Methods: We retrospectively studied gastroesophageal reflux disease patients between January 2014 and December 2018. Read More

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Network Pharmacology Analysis of Hewei Jiangni Granule for Gastroesophageal Reflux Disease and Experimental Verification of Its Anti-Neurogenic Inflammation Mechanism.

Drug Des Devel Ther 2022 5;16:1349-1363. Epub 2022 May 5.

Department of Gastroenterology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, People's Republic of China.

Purpose: Proton pump inhibitors, as the first-line drugs for treating gastroesophageal reflux disease (GERD), are unable to completely relieve patients' symptoms and patients are prone to recurrence after prolonged drug withdrawal. Thus, it is crucial to find herbal medicines as a complementary and alternative treatment. Hewei Jiangni granule (HWJNG) is a classical Chinese medicinal formula with clinical therapeutic effects on GERD, but its pharmacological mechanism of action remains unclear. Read More

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Gastroenterology 2022 May 7. Epub 2022 May 7.

Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University Medical Center, Nashville, TN.

Background And Aims: Studies with limited sample sizes have investigated association of chronic opioid use with motility disorders of esophagogastric junction and esophageal body peristalsis. Our aims were to use a large cohort of patients to assess: 1) the impact of opioid exposure on clinical and manometric characteristics and 2) the association of opioid exposure with higher long-term symptom burden.

Methods: Patients recruited from a tertiary medical center who underwent high-resolution manometry (HRM) between 2007 and 2018 were included. Read More

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Addendum: Dexlansoprazole for GERD.


Med Lett Drugs Ther 2022 05;64(1650):79-80

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Twenty Years of Antireflux Surgery. Retrospective of a Laparoscopic Surgery Center.

Chirurgia (Bucur) 2022 Apr;117(2):187-197

Non-oncological pathology of the esogastric junction (EGJ) is an area of interdisciplinary interest for many practitioners (endoscopist, gastroenterologist, surgeon, radiologist). This is due to the increased incidence of esogastric junction benign pathology, especially gastroesophageal reflux disease (GERD), currently considered the disease of the 21st century. The overall incidence of GERD is increasing annually. Read More

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Management of Esophageal Perforations During Achalasia Treatment Experience of the General and Esophageal Surgery Clinic, Sf Maria Hospital.

Chirurgia (Bucur) 2022 Apr;117(2):180-186

Achalasia is a motility disorder characterized by the absence of optimal relaxation of the lower esophageal sphincter (LES) with swallowing and lack of peristalsis of the esophageal body. Excepting temporary medical options, the treatment aims to lower the LES pressure by endoscopic or surgical means. Either method involves a risk of perforation. Read More

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Treatment of Achalasia in the Evidence-Based Medicine Era - A Quest in Search for a Proper Attitude by Reviewing the Present Guidelines.

Chirurgia (Bucur) 2022 Apr;117(2):154-163

The best way to start a paper like this is with a citation from W. Edwards Deming: Without data, you're just another person with an opinion. In the era of Evidence-Based Medicine (EBM) every surgical procedure has to be backed up by solid statistical data to offer our patients the best treatment. Read More

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Results in Antireflux Surgery, an Analysis of Case-Controlled Cohorts versus Multicenter Studies and Meta-Analyses.

Chirurgia (Bucur) 2022 Apr;117(2):134-142

With the advent of minimally invasive techniques, laparoscopic Nissen fundoplication and Toupet partial fundoplication have been very successful in the management of GERD. In the past 10 years, a number of very attractive new technologies have entered the market around therapeutic GERD-management such as Transoral Incisionless Gastroplication, other endoscopic plication techniques, and the implantation of the magnetic sphincter augmentation (MSA). These new technologies are excessively promoted by the respective companies, propagating their techniques as causing fewer side effects. Read More

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Can 18-years of data from a tertiary referral center help to identify risk factors in esophageal atresia?

Pediatr Int 2022 Jan;64(1):e15190

Department of Pediatric Surgery, Faculty of Medicine, Çukurova University, Adana, Turkey.

Background: Esophageal atresia is a complex esophageal malformation with an incidence of 1 in 3,500-4,000 live births, and it usually occurs together with anomalies in other systems or chromosomes. This study aimed to investigate the short-term and long-term results of cases of esophageal atresia retrospectively in our institution and to analyze the factors affecting the outcome.

Methods: Charts of the patients managed for esophageal atresia in our tertiary pediatric surgery department were investigated retrospectively. Read More

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January 2022



Nat Rev Dis Primers 2022 May 5;8(1):29. Epub 2022 May 5.

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Nat Rev Dis Primers 2022 May 5;8(1):28. Epub 2022 May 5.

Division of Gastroenterology, Washington University School of Medicine, St. Louis, MO, USA.

Achalasia is a rare disorder of the oesophageal smooth muscle characterized by impaired relaxation of the lower oesophageal sphincter (LES) and absent or spastic contractions in the oesophageal body. The key pathophysiological mechanism is loss of inhibitory nerve function that probably results from an autoimmune attack targeting oesophageal myenteric nerves through cell-mediated and, possibly, antibody-mediated mechanisms. Achalasia incidence and prevalence increase with age, but the disorder can affect all ages and both sexes. Read More

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Review of recent evidence on the management of heartburn in pregnant and breastfeeding women.

BMC Gastroenterol 2022 May 4;22(1):219. Epub 2022 May 4.

Department of Clinical Pharmacology, Galway University Hospital, The National University of Ireland, Galway, Ireland.

Gastroesophageal reflux disease (GERD) is one the most common medical complaints in pregnant women. Some women continue to experience GERD symptoms after delivery. Effective management of GERD symptoms is important to improve productivity and quality of life. Read More

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[Diagnosis of laryngopharyngeal Reflux by Impedance with esophageal pHmetry in children with chronic dysphonia].

Andes Pediatr 2021 Dec 8;92(6):847-853. Epub 2021 Sep 8.

Servicio de Otorrinolaringología, Hospital San Juan de Dios, Universidad de Chile, Santiago, Chile.

Introduction: Laryngopharyngeal Reflux (LPR) is the retrograde flow of gastric or duodenal contents into the pharynx and larynx, causing inflammation in the upper aerodigestive tract. Traditionally, a pH monitoring study with an acid reflux index was used. The use of multichannel intraluminal impedance testing with pH monitoring (MII-pH) confirms a causal relationship between suspicious symptoms and LPR. Read More

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December 2021

Psychosomatic Aspects and Treatment of Gastrointestinal Pathology.

Psychiatr Danub 2021 Spring-Summer;33(Suppl 4):1327-1329

Department of Psychiatry and Medical Psychology, Peoples' Friendship University of Russia (RUDN University), Moscow, Russia,

The frequency of instances of diseases of the digestive system has increased in recent years. The pattern of diseases changes: the pathology of the upper gastrointestinal tract (gastroesophageal reflux disease, gastritis, duodenitis) is the most prevalent. Gastroesophageal reflux disease (GERD) is one of the most common, recurrent and comorbid gastroenterological diseases, with a prevalence of 30% in Western Europe and 10% in East Asia in the adult population. Read More

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Analysis of the Quality of life and the Prevalence of Various Types of Mental Disorders in Patients with Isolated and Combined Somatic Pathology.

Psychiatr Danub 2021 Spring-Summer;33(Suppl 4):1284-1286

Department of psychiatry and medical psychology, Peoples' Friendship University of Russia (RUDN University), Moscow, Russia.

Background: The aim of the work is to compare the characteristics of quality of life and mental disorders in patients in the group with isolated gastroesophageal reflux disease (GERD) and in patients with combined pathology (GERD in combination with hypothyroidism).

Methods: Symptomatic questionnaire of Yu. Alexandrovich and questionnaire SF-36 were used. Read More

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Antacid Medication and Antireflux Surgery in Patients with Idiopathic Pulmonary Fibrosis: A Systematic Review and Meta-Analysis.

Ann Am Thorac Soc 2022 May;19(5):833-844

Department of Medicine, School of Medicine, Boston University, Boston, Massachusetts.

Idiopathic pulmonary fibrosis (IPF) is a fibrosing interstitial pneumonia with impaired survival. Previous guidelines recommend antacid medication to improve respiratory outcomes in patients with IPF. This systematic review was undertaken during the development of an American Thoracic Society, European Respiratory Society, Japanese Respiratory Society, and Asociación Latinoamericana del Tórax guideline. Read More

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Asthma and comorbidities: recent advances.

Pol Arch Intern Med 2022 04 28;132(4). Epub 2022 Apr 28.

Unit of Pharmacology, Department of Experimental Medicine, University of Campania “Luigi Vanvitelli,” Naples, Italy

Asthma is usually associated with pulmonary and extrapulmonary comorbidities that are more common in patients with severe asthma than in those with mild‑to‑moderate illness or in the general population. These comorbidities may affect the clinical intensity and severity of asthma and, as a result, increase health care costs related to its therapy. On the other hand, their recognition and appropriate treatment appear to improve asthma outcomes while optimizing therapy by preventing overtreatment. Read More

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Predictors of Long-Term Outcomes, Recurrent Dysphagia, and Gastroesophageal Reflux After Per-oral Endoscopic Myotomy in Esophageal Motility Disorders.

J Gastrointest Surg 2022 Apr 26. Epub 2022 Apr 26.

Asian Institute of Gastroenterology, 6-3-661, Somajiguda, Hyderabad, 500 082, India.

Background: There is limited data on long-term outcomes of per-oral endoscopic myotomy (POEM). In this study, we aim to evaluate the efficacy of POEM in patients who completed a minimum follow-up of 5 years.

Methods: Data of patients who underwent POEM and completed ≥ 5-year follow-up were analyzed, retrospectively. Read More

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Gastric peroral endoscopic myotomy for delayed gastric conduit emptying after pharyngo-laryngo-esophagectomy: a case report.

Hong Kong Med J 2022 Apr;28(2):169-171

Division of Esophageal and Upper Gastrointestinal Surgery, Department of Surgery, School of Clinical Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong.

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