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Front Genet 2020 28;11:384. Epub 2020 Apr 28.

Key Laboratory of Hunan Province for Internet of Things and Information Security, Xiangtan University, Xiangtan, China.

Recent studies have indicated that microRNAs (miRNAs) are closely related to sundry human sophisticated diseases. According to the surmise that functionally similar miRNAs are more likely associated with phenotypically similar diseases, researchers have proposed a variety of valid computational models through integrating known miRNA-disease associations, disease semantic similarity, miRNA functional similarity, and Gaussian interaction profile kernel similarity to discover the potential miRNA-disease relationships in biomedical researches. Taking account of the limitations of previous computational models, a new computational model based on biased heat conduction for MiRNA-Disease Association prediction (BHCMDA) was proposed in this paper, which can achieve the AUC of 0. Read More

AAS Open Res 2018 14;1:25. Epub 2019 Nov 14.

Department of medical Microbiology, Faculty of Medicine, University of Nairobi, Nairobi, Kenya.

Cancer in Africa is an emerging health problem. In Kenya it ranks third as a cause of death after infectious and cardiovascular diseases. Nearly 31% of the total cancer burden in sub-Saharan Africa is attributable to infectious agents. Read More

ACG Case Rep J 2019 Nov 28;6(11):e00267. Epub 2019 Nov 28.

Department of Gastroenterology, Rutgers New Jersey Medical School, Newark, NJ.

A 59-year-old man with diffuse large B-cell lymphoma, recently diagnosed from a renal biopsy, presented to the emergency department with melena, dizziness, and epigastric pain. He was tachycardic and had a hemoglobin level of 6.4 g/dL. Read More

J Extra Corpor Technol 2020 Mar;52(1):52-57

Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Veno-venous extracorporeal membrane oxygenation (VV-ECMO) has emerged as a potential life-saving treatment for patients with acute respiratory failure. Given the accumulating literature supporting the use of VV-ECMO without therapeutic levels of anticoagulation, it might be feasible to use it for planned intubation before surgical procedures. Here, we report consecutive series of patients who underwent planned initiation of VV-ECMO, without anticoagulation, before induction of general anesthesia for anticipated difficult airways or respiratory decompensation. Read More

Heliyon 2020 Mar 20;6(3):e03603. Epub 2020 Mar 20.

Centre for Radiation and Nuclear Physics, University of Surrey, Guildford, Surrey, GU2 7XH, UK.

Backgrounds: Throughout the world, there exists a clear need for the maintenance of cancer statistics, forming an essential part of any rational programme of cancer control, health-care planning, etiological research, primary and secondary prevention, benefiting both individuals and society. The present work reports only on the prevalence of cancers in the Oncology Department of Jamhuriyat Hospital, Kabul, Afghanistan following several decades of war.

Materials And Methods: A quantitative retrospective cross-sectional study was conducted using the medical records of patients diagnosed and treated from October 2015 to December 2017. Read More

Comput Struct Biotechnol J 2020 19;18:668-675. Epub 2020 Mar 19.

Biomedical Informatics Research Lab, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China.

Microsatellite instability (MSI) is a genomic property of the cancers with defective DNA mismatch repair and is a useful marker for cancer diagnosis and treatment in diverse cancer types. In particular, MSI has been associated with the active immune checkpoint blockade therapy response in cancer. Most of computational methods for predicting MSI are based on DNA sequencing data and a few are based on mRNA expression data. Read More

Curr Top Med Chem 2020 ;20(12):1124-1135

Medicinal Chemistry Division, CSIR- Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India.

Bryostatins are complex macrolactones isolated from marine organisms Bryozoan Bugula neritina. They are potent modulators of protein kinase C isozymes (PKCα: ki = 1.3-188 nM), and are one of the most extensively investigated marine natural products in clinical trials. Read More

J Gastrointest Oncol 2020 Feb;11(1):187-202

Department of Radiation Oncology, Perelman School of Medicine of the University of Pennsylvania, Perelman Center for Advanced Medicine, Philadelphia, PA, USA.

Background: Radiotherapy (RT) is part of the standard of care management of most gastrointestinal (GI) cancers. Even with advanced RT, systemic therapy, and surgical techniques, locoregional recurrences or second primary cancers can still occur within previously irradiated fields, which can present challenges in delivering effective and safe treatment. Options for reirradiation are often limited, but given the favorable dosimetric aspects of proton-beam RT, it may provide an effective and safe re-irradiation option for patients with recurrent or second primary GI cancers. Read More

Front Bioeng Biotechnol 2020 6;8:40. Epub 2020 Feb 6.

School of Medical Informatics, Xuzhou Medical University, Xuzhou, China.

As increasing experimental studies have shown that microRNAs (miRNAs) are closely related to multiple biological processes and the prevention, diagnosis and treatment of human diseases, a growing number of researchers are focusing on the identification of associations between miRNAs and diseases. Identifying such associations purely via experiments is costly and demanding, which prompts researchers to develop computational methods to complement the experiments. In this paper, a novel prediction model named Ensemble of Kernel Ridge Regression based MiRNA-Disease Association prediction (EKRRMDA) was developed. Read More

Immunol Lett 2020 04 31;220:44-50. Epub 2020 Jan 31.

First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Clinic Laboratory, Tianjin, China.

Background: CD3 and CD19 are the characteristic surface markers of mature T lymphocytes and B lymphocytes of human respectively. A special subset of immune cells that characteristically expressed the surface markers CD19+ of B lymphocytes and CD3+ of T lymphocytes simultaneously (CD19+CD3+ cells, hereinafter referred to as B-T cells) was found in the peripheral blood of human, yet it has not been reported in cancer research before. Our aims were to characterize the expression and possible value of B-T cells in cancer patients. Read More

Int J Mol Med 2020 Feb 4;45(2):279-297. Epub 2019 Dec 4.

Department of Omics Network, National Cancer Center, Tokyo 104‑0045, Japan.

NOTCH1, NOTCH2, NOTCH3 and NOTCH4 are transmembrane receptors that transduce juxtacrine signals of the delta‑like canonical Notch ligand (DLL)1, DLL3, DLL4, jagged canonical Notch ligand (JAG)1 and JAG2. Canonical Notch signaling activates the transcription of BMI1 proto‑oncogene polycomb ring finger, cyclin D1, CD44, cyclin dependent kinase inhibitor 1A, hes family bHLH transcription factor 1, hes related family bHLH transcription factor with YRPW motif 1, MYC, NOTCH3, RE1 silencing transcription factor and transcription factor 7 in a cellular context‑dependent manner, while non‑canonical Notch signaling activates NF‑κB and Rac family small GTPase 1. Notch signaling is aberrantly activated in breast cancer, non‑small‑cell lung cancer and hematological malignancies, such as T‑cell acute lymphoblastic leukemia and diffuse large B‑cell lymphoma. Read More

Clin Gastroenterol Hepatol 2019 Dec 27. Epub 2019 Dec 27.

Department of Gastroenterology and Hepatology, University of Texas Medical Branch at Galveston, Galveston, Texas.

Einstein (Sao Paulo) 2019 5;17(4):eMD5157. Epub 2019 Dec 5.

Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.

Elastography is a widely used procedure in conventional ultrasonography that has recently been incorporated in echoendoscopy. This is an innovative and promising technology that aims to increase the negative predictive value of endoscopic ultrasonography and fine-needle aspiration punctures. It is useful for directing punctures in suspect areas and, consequently, improves diagnostic performance. Read More

Asian Pac J Cancer Prev 2019 Nov 1;20(11):3221-3231. Epub 2019 Nov 1.

Harvard T.H. Chan School of Public Health, Department of Environmental Health, Environmental and Occupational Medicine and Epidemiology (EOME), Boston, MA, USA.

Objective: A systematic literature review and meta-analysis was conducted on the association between firefighting and cancer.

Methods: A comprehensive literature search of databases including Medline, EMBASE, Biosis, NIOSHTIC2, Web of Science, Cancerlit, and HealthStar, for the period between 1966 to January 2007, was conducted. We also retrieved additional studies by manual searching. Read More

Zhonghua Yu Fang Yi Xue Za Zhi 2019 Nov;53(11):1119-1123

Endoscopy room of the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011 China.

To investigate the association between the promoter region-938 polymorphism of B-cell lymphoma/leukemia-2 (2) gene and the esophageal cancer (EC) and gastric cardia adenocarcinoma (GCA) in Hebei Province. From 2007 to 2010, 145 esophageal cancer patients and 169 cardiaccancer patientsfrom the outpatient department of the Fourth Hospital of Hebei Medical Universitywereselected in a case group, and 195 non-tumor patients were selected in a control group during the same period. A questionnaire survey was used to collect information of research subjects. Read More

JAMA Dermatol 2019 Oct 16. Epub 2019 Oct 16.

Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester, United Kingdom.

Importance: The risk of cancer developing in people with psoriasis has raised some concern, with little clarity regarding differentiation in risk according to psoriasis severity.

Objective: To conduct a systematic review and meta-analysis of observational studies on the risk of cancer incidence and mortality in people with psoriasis.

Data Sources: Six electronic databases (MEDLINE, Embase, MEDLINE in Process, Cochrane Central Register, Web of Science, and LILACS [Literatura Latino-Americana e do Caribe em Ciências da Saúde]) were searched from inception to November 15, 2017, for eligible studies. Read More

Mediastinum 2019 Sep 9;3. Epub 2019 Sep 9.

Thoracic and Gastrointestinal Malignancies Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

A greater understanding of anti-tumor immunity has resulted in rapid development of immunotherapy for a wide variety of cancers. Antibodies targeting the immune checkpoints, cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), programmed death-1 (PD-1), or its ligand (PD-L1) have demonstrated clinical activity and are approved for treatment of melanoma, non-small cell lung cancer (NSCLC), renal cell carcinoma, bladder cancer, head and neck cancers, esophageal cancer, hepatocellular carcinoma, and Hodgkin lymphoma, among others. Treatment is generally well tolerated with relatively few adverse events compared with standard treatments such as chemotherapy. Read More

JCO Precis Oncol 2019 19;3. Epub 2019 Jun 19.

Rutgers University, New Brunswick, NJ.

Turk J Pediatr 2019;61(1):139-141

Departments of Pediatric Oncology, Kocaeli University Faculty of Medicine, Kocaeli, Turkey.

Demirsoy U, Alparslan B, Şen MC, Anık Y, Akansel G, Görür G, Gürel B, Aksu G, Çorapçıoğlu F. More than Ophelia syndrome: Multiple paraneoplastic syndromes in pediatric Hodgkin lymphoma. Turk J Pediatr 2019; 61: 139-141. Read More

Gastric Cancer 2020 01 23;23(1):133-141. Epub 2019 Sep 23.

Bristol-Myers Squibb Company, Lawrenceville, NJ, USA.

Background: There are few third-line or later (3L+) treatment options for advanced/metastatic (adv/met) gastric cancer/gastroesophageal junction cancers (GC/GEJC). 3L+ Nivolumab demonstrated encouraging results in Asian patients in the ATTRACTION-2 study compared with placebo (12-month survival, 26% vs 11%), and in Western patients in the single-arm CheckMate 032 study (12-month survival, 44%). This analysis aimed to establish comparator cohorts of US patients receiving routine care in real-world (RW) clinical practice. Read More

Isr Med Assoc J 2019 Sep;21(9):634-635

Department of Radiology, Stanford University School of Medicine, Stanford CA, USA.

J Pak Med Assoc 2019 Sep;69(9):1365-1368

Department of Pathology, King Fahad Hospital, Madinah, Kingdom of Saudi Arabia.

The oesophagus can be a site for a variety of lesions including inflammatory disorders, infections, mechanical conditions, toxic and physical injuries, vascular disorders and neoplastic conditions. hence the oesophageal diseases have a wide spectrum of pathological features. An understanding of histopathological details of oesophageal diseases is essential for their accurate diagnosis and management. Read More

Am J Gastroenterol 2020 02;115(2):161

Division of Gastroenterology, Department of Internal Medicine, Wayne State University, Detroit, Michigan, USA.

Anal Chim Acta 2019 Nov 5;1081:103-111. Epub 2019 Jul 5.

Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), Department of Chemistry, Wuhan University, Wuhan, 430072, PR China.

Both DNA cytosine methylation (5-methyl-2'-deoxycytidine, mdC) and RNA cytosine methylation (5-methylcytidine, mrC) are important epigenetic marks that play regulatory roles in diverse biological processes. mdC and mrC can be further oxidized by the ten-eleven translocation (TET) proteins to form 5-hydroxymethyl-2'-deoxycytidine (hmdC) and 5-hydroxymethylcytidine (hmrC), respectively. 2'-O-methyl-5-hydroxymethylcytidine (hmrCm) was recently also identified as a second oxidative metabolite of mrC in RNA. Read More

Saudi Med J 2019 Aug;40(8):755-765

Department of General Surgery, Peking University First Hospital, Beijing, People's Republic of China. E-mail.

Objectives: To analyze the heterogeneous functions of secreted protein acidic and rich in cysteine (SPARC) from different origins and in different tumor microenvironments with the purpose of determining its clinical significance. Methods: The PubMed, CINAHL, Cochrane, Web of Science and Embase databases were utilized. Studies that focused on the effects of SPARC expression on solid tumor progression and clinical implications were used. Read More

BMJ Case Rep 2019 Aug 12;12(8). Epub 2019 Aug 12.

Harvard Medical School, Boston, Massachusetts, USA.

A 69-year-old man with esophageal EBV-positive diffuse large B cell lymphoma status post allogeneic bone marrow transplant (BMT) five months prior presented to his oncologist with three days of maculopapular rash that was initially diagnosed as grade 1 graft-versus-host disease and started on oral prednisone. However, due to worsening of the rash, the patient presented to dermatology clinic, where skin biopsy revealed a diagnosis of erythema multiforme (EM). The patient improved with the use of topical steroids. Read More

J Transl Med 2019 08 8;17(1):260. Epub 2019 Aug 8.

School of Computer Science and Technology, China University of Mining and Technology, Xuzhou, 221116, China.

Background: Emerging evidences show that microRNA (miRNA) plays an important role in many human complex diseases. However, considering the inherent time-consuming and expensive of traditional in vitro experiments, more and more attention has been paid to the development of efficient and feasible computational methods to predict the potential associations between miRNA and disease.

Methods: In this work, we present a machine learning-based model called MLMDA for predicting the association of miRNAs and diseases. Read More

Hepatol Res 2019 Dec 9;49(12):1441-1450. Epub 2019 Oct 9.

Department of Hepatology and Okinaka Memorial Institute for Medical Research, Toranomon Hospital, Tokyo, Japan.

Aim: The long-term effects of sustained virologic response (SVR) to antiviral therapy on the risk of liver complications, such as exacerbation of esophageal varices (EV), hepatocellular carcinoma (HCC), malignant lymphoma, and liver-related and overall death in hepatitis C virus (HCV)-infected patients with liver cirrhosis are not fully known.

Methods: These risks were evaluated during long-term follow up of 457 patients with HCV-related Child-Pugh Class A liver cirrhosis without history of HCC.

Results: The respective cumulative 5- and 10-year rates of EV exacerbation were 2. Read More

Am J Med Sci 2019 09 4;358(3):200-203. Epub 2019 Jul 4.

Department of Medicine/Endocrinology, Division of Endocrinology, University of Tennessee Health Science Center, Memphis, Tennessee; Department of Research Services, Veterans Affairs Medical Center, Memphis, Tennessee. Electronic address:

Background: The biguanide drug metformin is one of the most commonly used medications for the treatment of type 2 diabetes mellitus. Diabetics are at an increased risk for cancer. Previous studies have demonstrated improved outcomes in patients taking metformin suffering from prostate, colon, lung, thyroid, and esophageal cancers. Read More

Drugs 2019 Aug;79(12):1355-1361

Springer Nature, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand.

Camrelizumab (AiRuiKa™), a programmed cell death 1 (PD-1) inhibitor being developed by Jiangsu Hengrui Medicine Co. Ltd, recently received conditional approval in China for the treatment of relapsed or refractory classical Hodgkin lymphoma. The drug is also being investigated as a treatment for various other malignancies, including B cell lymphoma, oesophageal squamous cell carcinoma, gastric/gastroesophageal junction cancer, hepatocellular carcinoma, nasopharyngeal cancer and non-squamous, non-small cell lung cancer. Read More

Cancer Med 2019 08 23;8(10):4519-4526. Epub 2019 Jun 23.

Cheeloo College of Medicine, ShanDong University, Jinan, China.

Considering the benefits of immunotherapy in advanced melanoma, non-small cell lung cancer, renal cell carcinoma, bladder cancers, and refractory Hodgkin lymphoma, we begin to consider whether immunotherapy is effective for esophageal cancer, which is extremely malignant and has a poor prognosis. There are a large number of clinical trials to study the application of immunotherapy such as immune checkpoint inhibitors, peptide vaccine, adoptive T cell transfer and oncolytic virus in esophageal cancer. Some already have preliminary results and show the advantages of immunotherapy in esophageal cancer, while others are still in progress. Read More

Exp Mol Med 2019 06 20;51(6):1-17. Epub 2019 Jun 20.

Department of Life Science, University of Seoul, Seoul, 02504, Korea.

Recent studies on mutations in cancer genomes have distinguished driver mutations from passenger mutations, which occur as byproducts of cancer development. The cancer genome atlas (TCGA) project identified 299 genes and 24 pathways/biological processes that drive tumor progression (Cell 173: 371-385 e318, 2018). Of the 299 driver genes, 12 genes are involved in histones, histone methylation, and demethylation (Table 1). Read More

Surg Oncol 2019 Jun 6;29:64-70. Epub 2019 Mar 6.

OncologyDepartment, ASST Ospedale di Cremona, Cremona, Italy.

Introduction: Gastrointestinal stromal tumors (GISTs) are rare mesenchymal tumors arising in the gastrointestinal tract. Second primary tumors (SPTs) have been reported frequently, either synchronously or during follow-up, in patients diagnosed with GISTs.

Methods: We carried out an electronic search of PubMed, SCOPUS, Web of Science, EMBASE, and the Cochrane Library seeking articles investigating the incidence of SPTs in patients with concomitant GIST. Read More

Oncol Lett 2019 Jun 19;17(6):5012-5022. Epub 2019 Mar 19.

Department of Thoracic Surgery, Qianfoshan Hospital Affiliated to Shandong University, Jinan, Shandong 250014, P.R. China.

Esophageal squamous cell carcinoma (ESCC) accounts for almost 90% of esophageal cancer cases and is the sixth most common cause of cancer-associated mortality worldwide. Cisplatin is the standard therapeutic reagent for ESCC; however, chemoresistance frequently occurs after a few weeks, which leads to ESCC recurrence. Aberrant expression of B lymphoma Mo-MLV insertion region 1 homolog (BMI1) has been reported to activate multiple growth-regulatory pathways, induce antiapoptotic abilities in numerous types of cancer cells and promote chemoresistance. Read More

PLoS One 2019 6;14(6):e0218094. Epub 2019 Jun 6.

Harvard Medical School, Boston, Massachusetts, United States of America.

Purpose: Men in Botswana present with more advanced cancer than women, leading to poorer outcomes. We sought to explain sex-specific differences in time to and stage at treatment initiation.

Methods: Cancer patients who initiated oncology treatment between October 2010 and June 2017 were recruited at four oncology centers in Botswana. Read More

J Cancer Res Clin Oncol 2019 Aug 1;145(8):2071-2082. Epub 2019 Jun 1.

Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.

Purpose: Fluorescence in situ hybridization (FISH) using tumor tissue is the gold standard for detection of anaplastic lymphoma kinase (ALK) rearrangement in non-small cell lung cancer (NSCLC). However, this method often is not repeatable due to difficulties in the acquisition of tumor tissues. Blood-based liquid biopsy using reverse transcription polymerase chain reaction (RT-PCR) is expected to be useful to overcome this limitation. Read More

Pan Afr Med J 2019 17;32:30. Epub 2019 Jan 17.

Service d'Hématologie, CHU Mohammed VI Marrakech, Maroc.

Primary mediastinal non-Hodgkin's lymphoma(PMNHL) is a rare cancer. Exceptionally, it can be complicated by tracheœsophageal fistulas, directly connecting the esophagus and the trachea and secondary to esophageal tumor or chemotherapy (hence the interest of our case). We report the case of a 24-year old Moroccan female patient, treated for primary mediastinal large B cell NHL revealed by dyspnœa associated with dysphagia and alteration of general condition. Read More

BMC Gastroenterol 2019 May 28;19(1):78. Epub 2019 May 28.

Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, No.300 of Guangzhou Road, Nanjing, 210029, China.

Background: Abdominal tuberculosis (TB) rarely presents with abdominal masses and rarely causes isolated gastric varices.

Case Presentation: We report a case of isolated gastric varices secondary to abdominal TB mimicking lymphoma. A 42-year-old woman without any history of liver disease presented with melena and mild abdominal pain. Read More

BMC Pulm Med 2019 May 24;19(1):101. Epub 2019 May 24.

Department of Thoracic Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University, College of Medicine, 199 Tun Hwa N. Rd, Taipei, Taiwan.

Background: Malignant endobronchial mass (MEM) has poor prognosis, cryotherapy is reportedly to diagnose MEM, however, the therapeutic role of cryotherapy impacts on survival has not be well addressed.

Methods: Cohort data on post-cryotherapy MEM patients in a university-affiliated hospital between 2007 and 2012 were evaluated. Factors that impact survival of these subjects were analyzed using multivariate regression analysis. Read More

J Diabetes 2019 Nov 8;11(11):878-883. Epub 2019 May 8.

Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.

Background: The aim of this study was to investigate the risk of 23 common types of cancer among patients with type 2 diabetes (T2D) compared with the general Chinese population.

Methods: Based on the Shanghai Hospital Link database, 410 191 patients with T2D (age 20-99 years) were identified from July 2013 to December 2016, and were followed-up for cancer incidence until December 2017.

Results: In all, 8485 cases of newly diagnosed cancer were identified. Read More

Case Rep Oncol 2019 Jan-Apr;12(1):39-46. Epub 2019 Jan 10.

Division of Gastroenterology, Bronx Lebanon Hospital Center, Bronx, New York, USA.

The gastrointestinal (GI) tract is the predominant site of extra nodal lymphoma involvement. In the United States (US), gastric lymphoma is the most common extra nodal site of lymphoma. Most of these lesions are either extra nodal marginal zone B cell lymphoma of mucosa associated lymphoid tissue (MALT) type or diffuse large B cell lymphoma (DLBCL). Read More

Ann Gastroenterol 2019 May-Jun;32(3):317. Epub 2019 Jan 23.

Sanford Gastroenterology, University of South Dakota, Sanford School of Medicine, Sioux Falls, SD, USA (Charoen Mankongpaisarnrung).

Mol Med Rep 2019 May 27;19(5):4019-4026. Epub 2019 Mar 27.

Department of General Surgery, The China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130000, P.R. China.

The role of ginsenoside in the prevention of cancer has been well established. Ginsenoside Rg5 is one of the main components isolated from red ginseng, which has been demonstrated to have anti‑tumor effects by inhibiting cell proliferation and causing DNA damage. However, the role of ginsenoside Rg5 and its molecular mechanisms remain unclear in human esophageal cancer. Read More

Am J Dermatopathol 2019 11;41(11):835-845

Department of Dermatology, University of Wisconsin, Madison, WI.

Palisaded neutrophilic granulomatous dermatitis (PNGD) presents as skin-colored to erythematous papules symmetrically distributed on extensor extremities. Histologically, interstitial and/or palisaded granulomatous infiltrates are present with neutrophils and leukocytoclasis. Together with interstitial granulomatous dermatitis (IGD), PNGD is considered a reactive granulomatous dermatitis to a systemic trigger including connective tissue disease, infection, medication reaction, and less commonly malignancy. Read More

Diagn Cytopathol 2019 Jul 21;47(7):725-732. Epub 2019 Mar 21.

Department of Pathology, Loyola University Medical Center, Maywood, Illinois.

Undifferentiated malignant SMARCA4-deficient neoplasms are rare, recently characterized, high grade, potentially lethal malignancies. Such tumors are characterized by the loss of BRG1 encoded by SMARCA4, a key component of the Switch/Sucrose Non-Fermenting (SWI/SNF) chromatin remodeling complex. As this complex, also referred as BAF (BRG1/BRM associated factors) complex, is involved in the epigenetic control of hundreds of genes, including those involved in lineage-specific differentiation, BAF-deficient tumors, show minimal or no differentiation and are difficult to classify. Read More

Curr Probl Cancer 2019 10 21;43(5):487-494. Epub 2019 Feb 21.

Clinical Radiology Deaprtment, The Royal Marsden NHS Foundation Trust.

Gastrointestinal cancers are very common cancers with colorectal being the fourth most common type, gastric the sixth, and esophageal the tenth. Although recent advances have been made in management including incorporation of antiangiogenic, anti-EGFR, and anti-HER2 directed therapies, overall their prognosis remains poor. Anti-PD-1 therapy with nivolumab and pembrolizumab are licensed for advanced chemorefractory gastroesophageal cancer and many other checkpoint inhibitor therapies are being assessed alone and in combination in these diseases. Read More

Medicine (Baltimore) 2019 Mar;98(9):e14699

Department of Internal Medicine, Chonnam National University Medical School.

Rationale: Current guidelines for advanced non-small cell lung cancer (NSCLC) recommend the use of targeted agents for specific driver genes after confirming genetic alterations. Although epidermal growth factor receptor (EGFR) mutation and anaplastic lymphoma kinase (ALK) rearrangement are usually mutually exclusive, EGFR and ALK co-alterations have been reported increasingly in cases of NSCLC. However, the optimal treatment for these cases has not been established. Read More

J Investig Med High Impact Case Rep 2018 Jan-Dec;6:2324709618820887

5 Abington - Jefferson Health, Abington, PA, USA.

Primary esophageal diffuse large B-cell lymphoma (DLBCL) is an extremely rare clinicopathologic entity. We report one case from our clinical experience and undertake a review of the previously published cases. A systematic literature search of the medical databases PubMed and Google Scholar was conducted. Read More