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Arch Phys Med Rehabil 2022 Jun 24. Epub 2022 Jun 24.

Department of Rehabilitation Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea. Electronic address:

Objective: To determine the effects of multimodal rehabilitation initiated immediately after esophageal cancer surgery on physical recovery compared to conventional pulmonary rehabilitation.

Design: Retrospective study.

Setting: Private quaternary care hospital. Read More

ESMO Open 2022 Jun 24;7(4):100519. Epub 2022 Jun 24.

Department of Medicine I, Division of Oncology, Medical University of Vienna, Vienna, Austria. Electronic address:

Background: Gastroesophageal adenocarcinoma is a major contributor to global disease burden with poor prognosis even in resectable, regionally limited stages. Feasible prognostic tools are crucial to improve patient management, yet scarce.

Patients And Methods: Disease-related symptoms, patient, tumour, treatment as well as laboratory parameters at initial diagnosis and overall survival (OS) of patients with stage II and III gastroesophageal adenocarcinoma, who were treated between 1990 and 2020 at the Medical University of Vienna, were evaluated in a cross-validation model to develop a feasible risk prediction score. Read More

J Gastrointest Cancer 2022 Jun 27. Epub 2022 Jun 27.

Singapore General Hospital, Outram Rd, Singapore, 169608, Singapore.

Background: Multidisciplinary tumor board (MDT) discussion is standard practice in the management of Upper Gastrointestinal (UGI) cancers. However, poor adherence to MDT recommendations may account for the lack of improved oncological outcomes with MDTs. We aim to quantify adherence rates and compare outcomes between adherent and non-adherent patients. Read More

Esophagus 2022 Jun 27. Epub 2022 Jun 27.

Department of Hemodialysis and Surgery, Chemotherapy Research Institute, International University of Health and Welfare, Ichikawa, Japan.

Cell Biochem Funct 2022 Jun 27. Epub 2022 Jun 27.

Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran.

Docetaxel (DTX) is a taxane chemotherapy agent used to treat many types of cancers, including esophageal squamous cell carcinoma. Adenosine is a purinergic signaling molecule that contributes to cancer cell proliferation via A2B adenosine receptor (A2BAR) activation. Extracellular signal-regulated protein kinase (ERK) plays a crucial role in cell proliferation in various types of cancers. Read More

Dis Esophagus 2022 Jun 25. Epub 2022 Jun 25.

Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.

Minimally invasive esophagectomy (MIE) is becoming more widespread with a documented improvement in postoperative morbidity based on level I evidence. However, there is a lack of consensus regarding the optimal MIE approach, conventional thoracoscopy/laparoscopy vs robotics as well as the ideal anastomotic technique. All patients who underwent MIE via an Ivor Lewis approach with a side-to-side stapled anastomosis were included. Read More

Dis Esophagus 2022 Jun 25. Epub 2022 Jun 25.

Department of Pathology and Laboratory Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA.

Pathologic complete response (pCR) to neoadjuvant chemoradiation for locally advanced esophageal adenocarcinoma (EAC) confers significantly improved survival. The ability to infer pCR may spare esophagectomy in some patients. Currently, there are no validated biomarkers of pCR. Read More

Histopathology 2022 Jun 27. Epub 2022 Jun 27.

Department of Surgery, National Defense Medical College, Japan.

Aims: Desmoplastic reaction (DR) categorization has been shown to be a promising prognostic factor in esophageal squamous cell carcinoma (ESCC). Usual DR evaluation is performed using semiquantitative scores which can be subjective. This study aimed to investigate whether a deep-learning classifier could be used for DR classification. Read More

Front Immunol 2022 10;13:845585. Epub 2022 Jun 10.

Medical Research Center, Yue Bei People's Hospital, Shantou University Medical College, Shaoguan, China.

The is a main activator of ATPase of Hsp90. Hsp90 is involved in various metabolic and developmental processes of tumor cells. Although, the role of in tumor cells is still unrecognized. Read More

Front Oncol 2022 8;12:859716. Epub 2022 Jun 8.

State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Air Force Medical University, Xi'an, China.

Background: Bile acids (BAs) have been proposed to promote gastrointestinal cells carcinogenesis. However, studies on serum total bile acid (TBA) levels and gastrointestinal cancers (GICs) risk are rare.

Methods: We conducted a retrospective case-control study from 2015 to 2019 at the First Affiliated Hospital of Air Force Military Medical University, in which 4,256 GICs cases and 1,333 controls were recruited. Read More

Front Oncol 2022 8;12:816270. Epub 2022 Jun 8.

Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.

Background: Perineural invasion (PNI) is a malignant metastatic mode of tumors and has been reported in many tumors including esophageal cancer (EC). However, the role of PNI in EC has been reported differently. This systematic review and meta-analysis aims to focus on the role of PNI in EC. Read More

Front Oncol 2022 10;12:810898. Epub 2022 Jun 10.

Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Institute of Thoracic Oncology, Fudan University, Shanghai, China.

Background: Immune checkpoint inhibitors (ICI) improve survival in patients with late-stage esophageal squamous cell carcinoma (ESCC) but have not been fully evaluated in locally advanced ESCC.

Method: We retrospectively assessed outcomes of consecutive, treatment-naïve locally advanced ESCC (stage III or IVA) adults treated with neoadjuvant ICI plus chemotherapy followed by surgery, who refused or lacked access to radiotherapy, with regards to surgery feasibility, pathological response, and relapse-free survival (RFS).

Results: We uneventfully treated 34 patients with the combined regimen in 2020. Read More

Front Oncol 2022 8;12:897534. Epub 2022 Jun 8.

Metabolic Epidemiology Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.

Objective: Explore the influence of family history of upper gastrointestinal (UGI) cancer on UGI cancer death, based on the Linxian Dysplasia Nutrition Intervention Trial (NIT) cohort.

Methods: Family history of UGI cancer was defined as at least one first-degree relative (parent, child, or sibling) had a history of esophageal or gastric cancer. Cancer death was carried out by ICD-10 code. Read More

Front Oncol 2022 10;12:855175. Epub 2022 Jun 10.

Department of Hepatobiliary Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China.

Objective: The aim of this study was to assess the diagnostic ability of artificial intelligence (AI) in the detection of early upper gastrointestinal cancer (EUGIC) using endoscopic images.

Methods: Databases were searched for studies on AI-assisted diagnosis of EUGIC using endoscopic images. The pooled area under the curve (AUC), sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR) with 95% confidence interval (CI) were calculated. Read More

Indian J Thorac Cardiovasc Surg 2022 Jul 13;38(4):445-447. Epub 2022 May 13.

Department of General Surgery, Tan Tock Seng Hospital, Singapore, Singapore.

Paraconduit hiatal hernia (PHH) remains a rare complication from oesophagectomies. Although minimally invasive oesophagectomies (MIO) for oesophageal cancer offer many advantages over open oesophagectomies (OO), the incidence of PHH appears to buckle this trend. As such, there is paucity in the current literature on the preferred approach as well as the management of PHH post-MIO. Read More

Dis Markers 2022 15;2022:4351949. Epub 2022 Jun 15.

Hebei Provincial Key Laboratory of Tumor Microenvironment and Drug Resistance, Hebei Medical University, Shijiazhuang 050017, China.

Background: Folic acid receptor 4 (FR4) significantly downregulates the expression of regular T cells (Treg) and improves the effect of chemotherapy and PD-1/PD-L1 inhibitors. However, the FR4 expression in squamous cell carcinoma (ESCC) remains unclear.

Methods: Patients with primary ESCC who visited our hospital between 1 February 2012 and 30 September 2016 were enrolled in this study. Read More

Front Surg 2022 9;9:898965. Epub 2022 Jun 9.

Department of Radiology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Taiyuan, China.

Purpose: To observe the application value of gastroenterography combined with CT in the evaluation of short-term efficacy and prognosis in patients with esophageal cancer radiotherapy.

Methods: From January 2013 to December 2020, the clinical data of 207 patients with esophageal cancer treated by radiotherapy in our hospital were collected retrospectively. All patients received gastroenterography and CT examination before and after radiotherapy, and the patients were followed-up for 1 year, and the evaluation value of their short-term efficacy and prognosis was observed. Read More

Front Microbiol 2022 9;13:883650. Epub 2022 Jun 9.

College of Clinical Medicine for Oncology, Fujian Medical University, Fuzhou, China.

Background: Acute radiation-induced esophagitis (ARIE) is one of the most debilitating complications in patients who receive thoracic radiotherapy, especially those with esophageal cancer (EC). There is little known about the impact of the characteristics of gut microbiota on the initiation and severity of ARIE.

Materials And Methods: Gut microbiota samples of EC patients undergoing radiotherapy ( = 7) or concurrent chemoradiotherapy ( = 42) were collected at the start, middle, and end of the radiotherapy regimen. Read More

J Immunol Res 2022 17;2022:2555647. Epub 2022 Jun 17.

Department of Thoracic Surgery, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, China.

Background: Thrombospondin type 1 domain-containing 7A () was reported to play a procancer role in esophageal squamous cell carcinoma (ESCC). The aim of the study was to screen the downstream functional genes of and explore their functions in ESCC, based on the reported research into function and on gene microarrays.

Methods: We adopted quantitative reverse-transcription polymerase chain reaction (qRT-PCR) and Celigo high-content screening (HCS) technology to screen the downstream genes of . Read More

Clin Med Insights Oncol 2022 20;16:11795549221105027. Epub 2022 Jun 20.

Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China.

Background: Volatile organic compounds (VOCs) have been involved in cancer diagnosis via breath, urine, and feces. We aimed to assess the diagnostic ability of VOCs on digestive cancers.

Methods: We systematically reviewed prospective clinical trials evaluating VOCs' diagnostic ability on esophageal, gastric, colorectal, hepatic, and pancreatic cancer (PC). Read More

Front Pharmacol 2022 8;13:873166. Epub 2022 Jun 8.

Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Esophageal squamous cell carcinoma (ESCC) is one of the deadliest digestive system cancers worldwide lacking effective therapeutic strategies. Recently, it has been found that the natural product celastrol plays an anti-cancer role in several human cancers by inducing cell cycle arrest and apoptosis. However, it remains elusive whether and how celastrol suppresses tumor growth of ESCC. Read More

Zhonghua Zhong Liu Za Zhi 2022 Jun;44(6):577-580

Department of Cardiothoracic Surgery, Zhongda Hospital Affiliated to Southeast University, Nanjing 210009, China.

To compare and analyze the perioperative clinical effects of minimally invasive Ivor-Lewis esophagectomy (MIE-Ivor-Lewis) and minimally invasive McKeown esophagectomy (MIE-McKeown). A total of 147 patients who underwent endoscopic esophageal cancer surgery from April 2018 to August 2019 were selected, including 85 patients undergoing MIE-McKeown surgery and 62 patients undergoing MIE-Ivor-Lewis surgery. The measurement data were expressed as (±), the comparison of normally distributed measurement data was performed by independent sample -test, and the comparison of count data was performed by (2) test or Fisher's exact test. Read More

Zhonghua Zhong Liu Za Zhi 2022 Jun;44(6):491-522

Shenzhen Centre for Chronic Disease Control, Shenzhen 518020, China.

Esophageal cancer (EC) is a major digestive tract malignancy in China, which seriously threatens the health of Chinese population. A large number of researches have demonstrated that screening and early detection are effective in reducing the incidence and mortality of EC. The development of the guideline for EC screening and early detection in line with epidemic characteristics of EC in China will greatly promote the homogeneity and standardization, and improve the effect of EC screening. Read More

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2020 Nov;45(11):1269-1275

Department of Gastroenterology, Nanshan People's Hospital, Shenzhen Guangdong 518052, China.

Objectives: To explore the effect of salvianolic acid A (SalA) on the proliferation and apoptosis in esophageal cancer cell line KYSE-150 and the possible mechanisms.

Methods: The esophageal cancer cells were randomly divided into 4 groups: a control group, a 10 μmol/L SalA group, a 25 μmol/L SalA group, and a 50 μmol/L SalA group. Cell counting kit-8 (CCK-8) was used to detect the cell proliferation activity. Read More

Brief Funct Genomics 2022 Jun 27. Epub 2022 Jun 27.

With the rapid advancement in sequencing technologies, the concept of omics has revolutionized our understanding of cellular behaviors. Conventional omics investigation approaches measure the averaged behaviors of multiple cells, which may easily hide signals represented by a small-cell cohort, urging for the development of techniques with enhanced resolution. Single-cell RNA sequencing, investigating cell transcriptomics at the resolution of a single cell, has been rapidly expanded to investigate other omics such as genomics, proteomics and metabolomics since its invention. Read More

Radiother Oncol 2022 Jun 23. Epub 2022 Jun 23.

Department of Radiation Oncology, University Hospital Zurich, University Zurich, Switzerland. Electronic address:

Purpose /objective: This multicenter study assessed the incidence and survival of patients with esophagogastric cancer and oligometastatic disease (OMD) in two tertiary referral cancer centers in The Netherlands and Switzerland.

Materials /methods: Between 2010-2021, patients with metastatic esophagogastric cancer were identified. Patients with de-novo OMD were included (first-time diagnosis of ≤5 distant metastases on F-FDG-PET/CT). Read More

J Transl Med 2022 Jun 25;20(1):285. Epub 2022 Jun 25.

Key Laboratory of Cellular Physiology of the Ministry of Education, Department of Pathology, Shanxi Medical University, Taiyuan, Shanxi, 030001, People's Republic of China.

Background: Aberrant glycosylation has been recognized as a hallmark of cancer and N-glycosylation is one of the main types of glycosylation in eukaryotes. Although N-glycoproteomics has made contributions to the discovery of biomarkers in a variety of cancers, less is known about the abnormal glycosylation signatures in esophageal squamous cell carcinoma (ESCC).

Methods: In this study, we reported the proteomics and N-glycoproteomic site-mapping analysis of eight pairs of ESCC tissues and adjacent normal tissues. Read More

Ann Surg Oncol 2022 Jun 25. Epub 2022 Jun 25.

Department of Upper Abdominal Surgery, Center for Digestive Diseases, Karolinska University Hospital, Stockholm, Sweden.

Background: Recent research indicates long-term survival benefits of minimally invasive esophagectomy (MIE) compared with open esophagectomy (OE) for patients with esophageal and gastroesophageal junction (GEJ) cancers, but there is a need for more population-based studies.

Methods: We conducted a prospective population-based nationwide cohort study including all patients in Sweden diagnosed with esophageal or junctional cancer who underwent a transthoracic esophagectomy with intrathoracic anastomosis. Data were collected from the Swedish National Register for Esophageal and Gastric Cancer in 2006-2019. Read More

J Cancer Res Clin Oncol 2022 Jun 25. Epub 2022 Jun 25.

Department of Oncology, Panyu Central Hospital, No. 8 Fuyu Road East, Panyu, Guangzhou, Guangdong, People's Republic of China.

Purpose: The benefit of immune checkpoint inhibitors' (ICIs) combination therapy in patients with advanced esophageal squamous cell carcinoma (ESCC) remained unclear. We performed a meta-analysis to explore the efficacy and safety of ICIs' combination therapy versus chemotherapy alone as first-line treatment in advanced ESCC.

Methods: A systematic review of randomized controlled trials (RCTs) of ICIs' combination therapy as first-line treatment in advanced ESCC was conducted via searching PubMed, Embase, and Cochrane database. Read More

Head Neck 2022 Jun 25. Epub 2022 Jun 25.

Department of Public Health, Kaohsiung Medical University, Kaohsiung, Taiwan.

Background: Patients with oral cancer are at higher risk of developing second primary esophageal cancer (SPEC) and the consensus for screening strategies remains unclear. This study aimed to examine comparative effectiveness and the stage-shift effect of endoscopic exam among patients with oral cancer.

Method: A population-based longitudinal retrospective observational matched case and control cohort study with at least 5 years follow-up was conducted. Read More