66,307 results match your criteria Esophageal Cancer


Histologic and Clinical Effects of Different Topical Corticosteroids for Eosinophilic Esophagitis: Lessons from an Updated Meta-Analysis of Placebo-Controlled Randomized Trials.

Digestion 2020 Jul 1:1-9. Epub 2020 Jul 1.

Institute of Medical Biometry and Epidemiology, University Hospital Hamburg-Eppendorf, Hamburg, Germany.

Background: Topical corticosteroids (TS) have become standard therapy for eosinophilic esophagitis (EoE). However, a variety of drug formulations have been used for which results of histological and clinical responses may be different. We aimed at determining the short-term histologic efficacy of TS for EoE based on randomized placebo-controlled trials and to review clinical response. Read More

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http://dx.doi.org/10.1159/000507571DOI Listing

Quantifying the interfractionalmotion of esophagus using daily cone beam computed tomography with oral contrast during radiotherapy for locally advanced non-small cell lung cancer.

Pract Radiat Oncol 2020 Jun 28. Epub 2020 Jun 28.

State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, P. R. China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, P. R. China; GuangDong Association Study of Thoracic Oncology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, P. R. China; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, P. R. China. Electronic address:

Background: and Purpose: To quantify the interfractional motion of the esophagus during fractionated radiotherapy for locally advanced non-small cell lung cancer (NSCLC).

Materials And Methods: We registered simulation four-dimensional computed tomography (4DCT) and daily cone beam CT (CBCT), and documented the motion of the esophagus centroid at 5mm-interval slices in right-left (RL) and anterior-posterior (AP) directions. Oral barium sulfate was administrated during CBCT to help localize the esophagus. Read More

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http://dx.doi.org/10.1016/j.prro.2020.06.006DOI Listing

Thoracic cancer surgery during the COVID-19 pandemic: A consensus statement from the Thoracic Domain of the Asian Society for Cardiovascular and Thoracic Surgery.

Asian Cardiovasc Thorac Ann 2020 Jul 1:218492320940162. Epub 2020 Jul 1.

Department of Thoracic Surgery, University of Tokyo Graduate School of Medicine, Tokyo, Japan.

Objectives: Healthcare resources have been mobilized to combat the COVID-19 pandemic of 2020. The Thoracic Domain of the Asian Society for Cardiovascular and Thoracic Surgery reports a consensus statement on the provision of thoracic cancer surgery during this pandemic.

Methods: A Thoracic Experts Panel was convened by the Society. Read More

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http://dx.doi.org/10.1177/0218492320940162DOI Listing

Household Fuel Use and the Risk of Gastrointestinal Cancers: The Golestan Cohort Study.

Environ Health Perspect 2020 Jun 17;128(6):67002. Epub 2020 Jun 17.

Digestive Oncology Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

Background: Three billion people burn nonclean fuels for household purposes. Limited evidence suggests a link between household fuel use and gastrointestinal (GI) cancers.

Objectives: We investigated the relationship between indoor burning of biomass, kerosene, and natural gas with the subsequent risk of GI cancers. Read More

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http://dx.doi.org/10.1289/EHP5907DOI Listing

[Esophageal and esophago-gastric junction cancer : management and multimodal treatment].

Rev Med Suisse 2020 Jul;16(699):1292-1299

Service de chirurgie viscérale, HUG, 1211 Genève 14.

Esophageal cancer remains an oncological burden with a low survival rate. Multidisciplinary management is essential to offer an adjusted treatment to the patient general condition and the tumor stage. New minimally invasive surgical treatments help to reduce the surgical trauma and improve post-operative patient recovery. Read More

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Does Neutrophil-to-Lymphocyte Ratio (NLR) Predict Pathologic Response to Neoadjuvant Chemoradiotherapy in Patients with Esophageal Squamous Cell Carcinoma?

J Gastrointest Cancer 2020 Jul 1. Epub 2020 Jul 1.

Department of Surgical Gastroenterology, JIPMER, Room no 5442, Fourth floor, Superspeciality block, Puducherry, 605006, India.

Background: Neoadjuvant chemoradiotherapy (nCRT), followed by surgery, is the current standard of care for patients with locally advanced esophageal squamous cell carcinoma. However, up to 30% of the patients do not respond to nCRT. Hence, a simple, cost-effective marker to predict response before initiation of nCRT is needed. Read More

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http://dx.doi.org/10.1007/s12029-020-00445-5DOI Listing

Pyogenic spondylodiscitis of the lumbar spine related to anastomotic fistula after surgery for esophageal cancer: a case report.

Surg Case Rep 2020 Jun 30;6(1):155. Epub 2020 Jun 30.

Department of Gastrointestinal Hepato-Biliary-Pancreatic Surgery, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan.

Background: Pyogenic spondylodiscitis is an extremely rare complication of esophagectomy for esophageal cancer.

Case Presentation: A 70-year-old Japanese man, with a previous medical history of type 2 diabetes mellitus, coronary artery disease, and laryngeal cancer, received neoadjuvant chemotherapy and underwent thoracoscopic esophagectomy with gastric tube reconstruction for advanced esophageal cancer. Cervical esophagogastrostomy with circular-stapled end-to-side anastomosis was performed. Read More

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http://dx.doi.org/10.1186/s40792-020-00922-wDOI Listing

Transthoracic Versus Transhiatal Esophagectomy for Esophageal Cancer: A Nationwide Propensity Score-Matched Cohort Analysis.

Ann Surg Oncol 2020 Jun 30. Epub 2020 Jun 30.

Amsterdam UMC, Department of Surgery, Cancer Center Amsterdam, University of Amsterdam, Amsterdam, The Netherlands.

Background: Chemoradiation followed by resection has been the standard therapy for resectable (cT1-4aN0-3M0) esophageal carcinoma in the Netherlands since 2010. The optimal surgical approach remains a matter of debate. Therefore, the purpose of this study was to compare the transhiatal and the transthoracic approach concerning morbidity, mortality and oncological quality. Read More

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http://dx.doi.org/10.1245/s10434-020-08760-8DOI Listing

Multicenter study on the diagnostic performance of multiframe volumetric laser endomicroscopy targets for Barrett's esophagus neoplasia with histopathology correlation.

Dis Esophagus 2020 Jul 1. Epub 2020 Jul 1.

Department of Gastroenterology and Hepatology, Catharina Hospital, Eindhoven, The Netherlands.

Volumetric laser endomicroscopy (VLE) has been shown to improve detection of early neoplasia in Barrett's esophagus (BE). However, diagnostic performance using histopathology-correlated VLE regions of interest (ROIs) has not been adequately studied. We evaluated the diagnostic accuracy of VLE assessors for identification of early BE neoplasia in histopathology-correlated VLE ROIs. Read More

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http://dx.doi.org/10.1093/dote/doaa062DOI Listing

Response to: 'Unified definition of relapse-free survival should be used for evaluating survival benefit in oesophageal adenocarcinoma' by Li.

Gut 2020 Jun 30. Epub 2020 Jun 30.

Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK

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http://dx.doi.org/10.1136/gutjnl-2020-322096DOI Listing

Global burden of oesophageal and gastric cancer by histology and subsite in 2018.

Gut 2020 Jun 30. Epub 2020 Jun 30.

Section of Cancer Surveillance, International Agency for Research on Cancer, Lyon, France.

Objectives: To provide updated estimates of the global burden of oesophageal and gastric cancer by subsite and type.

Methods: Using data from population-based cancer registries, proportions of oesophageal adenocarcinoma (OAC) and squamous cell carcinoma (OSCC) out of all oesophageal as well as cardia gastric cancer (CGC) and non-CGC (NCGC) out of all gastric cancer cases were computed by country, sex and age group. Proportions were subsequently applied to the estimated numbers of oesophageal and gastric cancer cases from GLOBOCAN 2018. Read More

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http://dx.doi.org/10.1136/gutjnl-2020-321600DOI Listing

Successful Management of Esophageal Cancer With Perforation Using Bypass Surgery Followed by Definitive Chemoradiotherapy.

In Vivo 2020 Jul-Aug;34(4):2169-2172

Department of Surgical Oncology, Hiroshima University, Hiroshima, Japan.

Background: Esophageal perforation in advanced esophageal cancer requires immediate treatment. However, no clear treatment protocol has been established for this condition. We report a case of advanced esophageal cancer with esophageal perforation treated with esophageal bypass surgery and definitive chemoradiotherapy (CRT). Read More

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http://dx.doi.org/10.21873/invivo.12025DOI Listing

Laparoscopic-assisted Esophageal Bypass for T4b Esophageal Tumor as a Bridge to Definitive Therapy.

In Vivo 2020 Jul-Aug;34(4):2163-2168

First Department of Surgery, Upper Gastrointestinal and General Surgery Unit, Laiko General Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Background/aim: Esophagobronchial fistula is a common complication of advanced esophageal cancer, related to respiratory distress and mortality. Esophageal bypass has been successfully utilized for palliation, as bridging to definitive chemoradiotherapy. The aim of this study is to present an extremely difficult case of a mid-esophageal squamous cell carcinoma complicated with aerodigestive fistula that was treated using 3D laparoscopic-assisted esophageal bypass with curative intent. Read More

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http://dx.doi.org/10.21873/invivo.12024DOI Listing
January 2020

The Lymph Node Ratio Is an Independent Prognostic Factor in Esophageal Cancer Patients Who Receive Curative Surgery.

In Vivo 2020 Jul-Aug;34(4):2087-2093

Department of Surgery, Yokohama City University, Yokohama, Japan.

Background/aim: We investigated the clinical impact of the lymph node ratio (LNR) on overall survival (OS) and recurrence-free survival (RFS) in esophageal cancer patients who underwent curative surgery.

Patients And Methods: One hundred twenty patients who underwent curative surgery for esophageal cancer between 2005 and 2017 were included in this study. The LNR was defined as the ratio of the number of metastatic lymph nodes (LNs) to the total number of harvested LNs. Read More

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http://dx.doi.org/10.21873/invivo.12012DOI Listing

The Number of Harvested LNs Is an Independent Prognostic Factor in Lymph Node Metastasis-negative Patients Who Received Curative Esophagectomy.

In Vivo 2020 Jul-Aug;34(4):2021-2027

Department of Surgery, Yokohama City University, Yokohama, Japan.

Background/aim: The aim of the present study was to evaluate the optimal number of harvested LNs (LNs) in patients who were LN metastasis-negative after curative esophagectomy for esophageal cancer.

Patients And Methods: Sixty-one patients who underwent curative surgery for esophageal cancer between 2005 and 2017 and diagnosed as lymph node metastasis-negative were included in this study.

Results: The 5-year overall survival rates were 27. Read More

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http://dx.doi.org/10.21873/invivo.12001DOI Listing

Impact of Antiplatelet and Anticoagulant Therapies on Platelet-related Prognostic Markers in Patients With Esophageal Cancer.

In Vivo 2020 Jul-Aug;34(4):1941-1949

Department of Surgery, National Defense Medical College, Saitama, Japan.

Background/aim: In recent years, platelet-related markers were recognized as useful prognostic factors in various malignancies. We investigated the relationship between platelet-related prognostic markers and anti-platelet or anti-coagulant therapies for survival outcomes in esophageal squamous cell carcinoma.

Patients And Methods: Preoperative platelet-related prognostic markers were evaluated from peripheral blood testing and statistical analyses were performed to evaluate the prognostic value of these markers and reveal the effects of antiplatelets and/or anticoagulants regarding their prognostic relevance. Read More

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http://dx.doi.org/10.21873/invivo.11991DOI Listing

Isolated oesophageal adenocarcinoma metastasis at percutaneous endoscopic gastrostomy (PEG) site.

BMJ Case Rep 2020 Jun 30;13(6). Epub 2020 Jun 30.

Department of General and Upper GI Surgery, St James Hospital, Dublin, Ireland

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http://dx.doi.org/10.1136/bcr-2020-236778DOI Listing

Voice-Related Quality of Life in Post-Laryngectomy Rehabilitation: Tracheoesophageal Fistula's Wellness.

Int J Environ Res Public Health 2020 Jun 26;17(12). Epub 2020 Jun 26.

Department of Medical and Surgical Sciences and Advanced Technologies "GF Ingrassia", ENT Section, University of Catania, 95100 Catania, Italy.

(1) Introduction: Laryngeal cancer is one of the most common types of cancer affecting the upper aerodigestive tract. Despite ensuring good oncological outcome in many locoregionally advanced cases, total laryngectomy is associated with relevant physical and psychological sequelae. Treatment through tracheo-esophageal speech, if promising, can lead to very variable outcomes. Read More

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http://dx.doi.org/10.3390/ijerph17124605DOI Listing

Clinicopathological features and outcome of esophageal neuroendocrine tumor: A retrospective multicenter survey by the digestive endoscopy society of Taiwan.

J Formos Med Assoc 2020 Jun 27. Epub 2020 Jun 27.

Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University, College of Medicine, Taipei, Taiwan. Electronic address:

Background & Aims: Esophageal neuroendocrine tumors (NET) are very rare and mostly carcinomic, carrying poor prognosis. There is still no guideline or consensus on the treatment for esophageal NET.

Methods: Patients with histologically-proven esophageal neuroendocrine tumor were recruited from 9 hospitals in Taiwan between 2002 and 2017. Read More

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http://dx.doi.org/10.1016/j.jfma.2020.06.024DOI Listing

Lymphography and embolization of the thoracic duct as a treatment for chylothorax after esophagectomy for esophageal cancer.

Cir Esp 2020 Jun 26. Epub 2020 Jun 26.

Unitat de Cirurgia Esofagogàstrica, Servei de Cirurgia General i Aparell Digestiu, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, España.

Introduction: Chylothorax is a rare complication in esophagectomies that is associated with increased postoperative mortality. Several factors have been described that may favor its appearance. Its treatment is controversial, and lymphography with percutaneous embolization of the thoracic duct is used by several groups. Read More

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http://dx.doi.org/10.1016/j.ciresp.2020.05.015DOI Listing

High expression of RABL6 promotes cell proliferation and predicts poor prognosis in esophageal squamous cell carcinoma.

BMC Cancer 2020 Jun 29;20(1):602. Epub 2020 Jun 29.

Department of Thoracic Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510080, People's Republic of China.

Background: Esophageal squamous cell carcinoma (ESCC) is a common malignant carcinoma of digestive system with high mortality. RAB, member RAS oncogene family like 6 (RABL6), a member of the RAS subfamily, has been reported as an important molecule in several cancers. However, its potential role in ESCC still remains unclear. Read More

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http://dx.doi.org/10.1186/s12885-020-07068-wDOI Listing

Orthotopic liver transplantation for Management of a Giant Liver Hemangioma: a case report and review of literature.

BMC Surg 2020 Jun 29;20(1):142. Epub 2020 Jun 29.

Shiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Hepatic hemangioma (HH) is the most common benign tumor of the liver. In special conditions such as rapidly growing tumors, persistent pain, hemorrhage and when pressure effect on adjacent organs exist treatment is indicated. Surgical management is the most common treatment for HH. Read More

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http://dx.doi.org/10.1186/s12893-020-00801-zDOI Listing

MAGE-A4, NY-ESO-1 and SAGE mRNA expression rates and co-expression relationships in solid tumours.

BMC Cancer 2020 Jun 29;20(1):606. Epub 2020 Jun 29.

Department of Immuno-Gene Therapy, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.

Background: Cancer testis (CT) antigens are promising targets for cancer immunotherapies such as cancer vaccines and genetically modified adoptive T cell therapy. In this study, we evaluated the expression of three CT antigens, melanoma-associated antigen A4 (MAGE-A4), New York oesophageal squamous cell carcinoma 1 (NY-ESO-1) and sarcoma antigen gene (SAGE).

Methods: MAGE-A4, NY-ESO-1 and/or SAGE antigen expression in tumour samples was evaluated by quantitative real-time polymerase chain reaction (qRT-PCR). Read More

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http://dx.doi.org/10.1186/s12885-020-07098-4DOI Listing

Incidence and Onset of Severe Cardiac Events After Radiotherapy for Esophageal Cancer.

J Thorac Oncol 2020 Jun 26. Epub 2020 Jun 26.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. Electronic address:

Purpose: Late cardiotoxicity related to radiotherapy (RT) in breast cancer and Hodgkin lymphoma has been well reported. However, the relatively higher cardiac dose exposure for esophageal cancer (EC) may result in earlier onset of cardiac diseases. In this report, we examined the incidence, onset, and long-term survival outcomes of high-grade cardiac events after RT in a large cohort of EC patients. Read More

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http://dx.doi.org/10.1016/j.jtho.2020.06.014DOI Listing

Five-lncRNA signature in plasma exosomes serves as diagnostic biomarker for esophageal squamous cell carcinoma.

Aging (Albany NY) 2020 Jun 28;12. Epub 2020 Jun 28.

Department of Cardiothoracic Surgery, Nanjing Drum Tower Hospital, Nanjing Medical University, Nanjing, China.

Changes in expression of long non-coding RNAs (lncRNAs) in plasma exosomes can be useful for diagnosis of cancer patients. Here, we conducted a four-stage study to identify plasma exosome lncRNAs with diagnostic potential in esophageal squamous cell carcinoma (ESCC). First, plasma exosome lncRNA expression profiles were examined in ESCC patients, esophagitis patients, and healthy controls using RNA sequencing. Read More

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http://dx.doi.org/10.18632/aging.103559DOI Listing

Controlling lymph node micrometastases by neoadjuvant chemotherapy affects the prognosis in advanced esophageal squamous cell carcinoma.

Surg Today 2020 Jun 28. Epub 2020 Jun 28.

Department of Surgery, Kindai University Faculty of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Osaka, 589-8511, Japan.

Purpose: The purpose of this study is to determine the clinical significance of micrometastases after neoadjuvant chemotherapy (NAC) and the difference in controlling micrometastases using different NAC regimens in resectable advanced esophageal squamous cell carcinoma (ESCC).

Methods: We analyzed patients with ESCC who underwent esophagectomy with lymph node dissection after NAC with Adriamycin + cisplatin + 5-fluorouracil (ACF) or docetaxel + cisplatin + 5-fluorouracil (DCF). Micrometastasis was defined as a single isolated cancer cell or cluster of cancer cells on the cervical, recurrent nerve, or abdominal LNs as shown by immunohistochemical staining with anti-cytokeratin antibody (AE1/AE3). Read More

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http://dx.doi.org/10.1007/s00595-020-02059-7DOI Listing

Ubiquitin C-Terminal Hydrolase L5 (UCHL5) Accelerates the Growth of Endometrial Cancer via Activating the Wnt/β-Catenin Signaling Pathway.

Front Oncol 2020 11;10:865. Epub 2020 Jun 11.

Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.

Endometrial cancer (EC) is the most prevalent gynecological malignancy with high mortality. Chemotherapy plays a pivotal role both in an adjuvant setting and in exclusive treatment. However, current pharmacotherapies are limited and not ideal for improving the overall survival of EC patients. Read More

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http://dx.doi.org/10.3389/fonc.2020.00865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300206PMC

Acute Respiratory Failure Secondary to COVID-19 Viral Pneumonia Managed With Hydroxychloroquine/Azithromycin Treatment.

Cureus 2020 May 25;12(5):e8268. Epub 2020 May 25.

Anesthesiology, State University of New York Downstate Medical Center, Brooklyn, USA.

A 74-year-old male was admitted to the Intensive Care Unit (ICU) at State University of New York (SUNY) Downstate Medical Center following acute respiratory failure secondary to coronavirus disease 2019 (COVID-19) viral pneumonia. The patient had significant comorbidities, including a history of lung and esophageal cancer status-post resection, cerebrovascular accident with neurological deficits, diabetes mellitus, hypertension, and peripheral vascular disease. The patient was in septic shock and respiratory failure on admission requiring intubation and mechanical ventilation. Read More

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http://dx.doi.org/10.7759/cureus.8268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314365PMC

Effect of Transcutaneous Electrical Acupoint Stimulation on One-Lung Ventilation-Induced Lung Injury in Patients Undergoing Esophageal Cancer Operation.

Evid Based Complement Alternat Med 2020 7;2020:9018701. Epub 2020 Jun 7.

Department of Thoracic Surgery, Tangshan People's Hospital, North China University of Science and Technology, Tangshan 063000, China.

Objective: To investigate the effect of transcutaneous electrical acupoint stimulation (TEAS) on one-lung ventilation-induced injury in patients undergoing esophageal cancer operation.

Methods: The participants ( = 121) were randomly assigned into TEAS and sham groups. The TEAS group was given transcutaneous electrical stimulation therapy. Read More

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http://dx.doi.org/10.1155/2020/9018701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298312PMC

Impact of combined assessment of systemic inflammation and presarcopenia on survival for surgically resected esophageal cancer.

Am J Surg 2020 May 27. Epub 2020 May 27.

Division of Gastroenterological Surgery, Department of General Surgical Science, Gunma University, Graduate School of Medicine, Japan.

Background: Systemic inflammation and low skeletal muscle volume (presarcopenia) have received increasing attention in many malignancies. However, their association and the combined effect on postoperative survival in esophageal cancer (EC) patients have been poorly studied.

Methods: Eighty-nine patients with EC who underwent surgery between 2006 and 2014 were included in this study. Read More

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http://dx.doi.org/10.1016/j.amjsurg.2020.05.029DOI Listing

Screening dysphagia risk in 534 older patients undergoing rehabilitation after total joint replacement. A cross-sectional study.

Eur J Phys Rehabil Med 2020 Jun 26. Epub 2020 Jun 26.

Rehabilitation Unit, 'Mons. L. Novarese' Hospital, Moncrivello, Vercelli, Italy.

Background: Older people affected by severe osteoarthritis could need to undergo total joint replacement, with a consequent hospitalization and rehabilitation. In this post-acute phase, they might suffer from other symptoms, including dysphagia, defined as a dysfunction of the digestive system, characterized by an objective difficulty or a sensation of difficulty in swallowing. It is considered as a very challenging problem in older people and early detection is fundamental for a prompt and effective management. Read More

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http://dx.doi.org/10.23736/S1973-9087.20.06321-2DOI Listing

Fluorescence Imaging of Breast Tumors and Gastrointestinal Cancer.

Recent Results Cancer Res 2020 ;216:591-624

Klinik für Radiologie, St. Franziskus Hospital GmbH, Hohenzollernring 70, 48145, Münster, Germany.

Optical imaging offers a high potential for noninvasive detection and therapy of cancer in humans. Recent advances in instrumentation for diffuse optical imaging have led to new capabilities for the detection of cancer in highly scattering tissue such as the female breast. In particular, fluorescence imaging was made applicable as a sensitive technique to image molecular probes in vivo. Read More

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http://dx.doi.org/10.1007/978-3-030-42618-7_18DOI Listing
January 2020

Irinotecan-Associated Dysarthria in Patients with Pancreatic Cancer: A Single Site Experience.

Am J Case Rep 2020 Jun 28;21:e924058. Epub 2020 Jun 28.

Division of Ambulatory Care, Oncology Unit, Winchester District Memorial Hospital, Winchester, ON, Canada.

BACKGROUND Irinotecan, a topoisomerase I inhibitor, is a cytotoxic chemotherapeutic agent used to treat multiple malignancies, including those of colorectal, pancreatic, cervical, esophageal, gastric, and lung origin. Dysarthria, a state of difficult or unclear articulation of speech, has been reported as a rare side effect of irinotecan through multiple case reports and case series, but with limited published data aimed at understanding the underlying mechanism and effective management strategies. CASE REPORT We describe herein 3 cases of patients with pancreatic malignancy who experienced dysarthria while being treated with a chemotherapy regimen containing irinotecan at an ambulatory outpatient satellite chemotherapy site. Read More

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http://dx.doi.org/10.12659/AJCR.924058DOI Listing

Management of Complications After Esophagectomy.

Authors:
Jonathan C Yeung

Thorac Surg Clin 2020 Aug 22;30(3):359-366. Epub 2020 May 22.

Toronto General Hospital, 200 Elizabeth Street 9N-983, Toronto, Ontario M5G 2C4, Canada. Electronic address:

Esophagectomy is a complex operation with many potential complications. Early recognition of postoperative complications allows for the best chance for patient survival. Diagnosis and management of conduit complications, including leak, necrosis, and conduit-airway fistulae, are reviewed. Read More

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http://dx.doi.org/10.1016/j.thorsurg.2020.04.002DOI Listing

Open, Minimally Invasive, and Robotic Approaches for Esophagectomy: What Is the Approach Algorithm?

Thorac Surg Clin 2020 Aug;30(3):269-277

University of Pittsburgh Medical Center, University of Pittsburgh School of Medicine, Shadyside Medical Building, 5200 Centre Avenue, Suite 715, Pittsburgh, PA 15232, USA.

Esophageal cancer requires a multimodality treatment approach, with surgical resection a key component in many cases. When it comes to esophagectomy, several approaches and techniques exist, including transhiatal versus transthoracic and open versus minimally invasive. Each approach has its associated risks and advantages. Read More

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http://dx.doi.org/10.1016/j.thorsurg.2020.04.010DOI Listing

Socioeconomic and administrative factors associated with treatment delay of esophageal and gastric carcinoma: Prospective study from a tertiary care centre in a developing country.

Cancer Epidemiol 2020 Jun 24;67:101770. Epub 2020 Jun 24.

Department of Medical Oncology, Kidwai Memorial Institute of Oncology, India. Electronic address:

This study was aimed to analyze the spectrum of time intervals, from the onset of symptoms to the commencement of treatment in esophagogastric cancers. Factors influencing these time delays and correlation between these time points with variables including socioeconomic strata, educational level, histopathology, location of tumor and the initial modality of treatment were assessed.

Study Setting And Methods: A prospective analysis of patients with esophagogastric cancer presenting to a single tertiary care unit over a period of 12 months was performed. Read More

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http://dx.doi.org/10.1016/j.canep.2020.101770DOI Listing

Diversity-oriented generation and biological evaluation of new chemical scaffolds bearing a 2,2-dimethyl-2H-chromene unit: Discovery of novel potent ANO1 inhibitors.

Bioorg Chem 2020 Jun 8;101:104000. Epub 2020 Jun 8.

College of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon 21983, Republic of Korea. Electronic address:

Chemical territory bearing a 2,2-dimethyl-2H-chromene motif was expanded by utilizing an o-hydroxy aldehyde group of 5-hydroxy-2,2-dimethyl-2H-chromene-6-carbaldehyde as a synthetic handle to install distinctive morphology and functionality of each scaffold. Cell based assays and in silico docking analysis led us to discover that these new compounds exhibit inhibitory effect on anoctamin1 (ANO1). ANO1 is amplified and highly expressed in various carcinomas including prostate cancer, esophageal cancer, breast cancer, and pancreatic cancer. Read More

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http://dx.doi.org/10.1016/j.bioorg.2020.104000DOI Listing

Surgical intervention for portal hypertension caused by oxaliplatin-based chemotherapy: a case report and a review of literature regarding radiological and/or surgical interventions for oxaliplatin-associated portal hypertension.

Clin J Gastroenterol 2020 Jun 26. Epub 2020 Jun 26.

Department of Surgery, Yokohama Ekisaikai Hospital, 1-2 Yamada-cho, Naka-ku, Yokohama, 231-0036, Japan.

A 63-year-old man showed massive ascites, massive pleural effusion, severe lower-extremity edema, and repeated esophageal variceal bleeding. Two-year previously, he received 13-courses of oxaliplatin-based chemotherapy (OBC) followed by associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) for multiple colorectal cancer liver metastases but developed a solitary remaining liver metastasis and multiple lung metastases 2 months after the ALPPS, for which multiple regimens of chemotherapy were conducted. The symptoms were considered attributable to the OBC-associated portal-hypertension. Read More

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http://dx.doi.org/10.1007/s12328-020-01157-wDOI Listing

Prognostic Implication of Postoperative Weight Loss After Esophagectomy for Esophageal Squamous Cell Cancer.

Ann Surg Oncol 2020 Jun 27. Epub 2020 Jun 27.

Department of Digestive Surgery, Osaka International Cancer Institute, Osaka, Japan.

Background: Preoperative weight loss in esophageal cancer is reported to be associated with a poor prognosis. However, the impact of postoperative weight loss on the prognosis of patients with esophageal cancer remains unclear.

Methods: This study included 186 patients with esophageal squamous cell carcinoma who underwent surgery between January 2012 and January 2015. Read More

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http://dx.doi.org/10.1245/s10434-020-08762-6DOI Listing

ASO Author Reflections: Prediction of the Therapeutic Efficacy in Patients with Neoadjuvant Chemotherapy for Esophageal Squamous Cell Carcinoma.

Ann Surg Oncol 2020 Jun 26. Epub 2020 Jun 26.

Department of Gastroenterological Surgery, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan.

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http://dx.doi.org/10.1245/s10434-020-08772-4DOI Listing

Histological intratumoral heterogeneity in pretreatment esophageal cancer biopsies predicts survival benefit from neoadjuvant chemotherapy: results from the UK MRC OE02 trial.

Dis Esophagus 2020 Jun 27. Epub 2020 Jun 27.

Department of Pathology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center + Maastricht, The Netherlands.

Despite the use of multimodal treatment, survival of esophageal cancer (EC) patients remains poor. One proposed explanation for the relatively poor response to cytotoxic chemotherapy is intratumor heterogeneity. The aim was to establish a statistical model to objectively measure intratumor heterogeneity of the proportion of tumor (IHPoT) and to use this newly developed method to measure IHPoT in the pretreatment biopsies from from EC patients recruited to the OE02 trial. Read More

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http://dx.doi.org/10.1093/dote/doaa058DOI Listing

Comparison of Esophagectomy outcomes between a National Center, a National Audit Collaborative, and an International database using the Esophageal Complications Consensus Group (ECCG) standardized definitions.

Dis Esophagus 2020 Jun 27. Epub 2020 Jun 27.

Virginia Mason Medical Center, Seattle, WA, USA.

The ECCG developed a standardized platform for reporting operative complications, with consensus definitions. The Dutch Upper Gastrointestinal Cancer Audit (DUCA) published a national comparison against these benchmarks. This study compares ECCG data from the Irish National Center (INC) with both published benchmark studies. Read More

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http://dx.doi.org/10.1093/dote/doaa060DOI Listing

Skeletal muscle loss in the postoperative acute phase after esophageal cancer surgery as a new prognostic factor.

World J Surg Oncol 2020 Jun 26;18(1):143. Epub 2020 Jun 26.

Department of Gastroenterological Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikatacho, Kita-ku, Okayama, 700-8558, Japan.

Background: The postoperative survival rate of patients with esophageal squamous cell carcinoma (ESCC) remains poor compared with other gastrointestinal cancers. We hypothesized that skeletal muscle loss in the postoperative acute phase might be a new predictor for long-term prognosis after highly invasive surgery such as ESCC surgery.

Methods: The following items were retrospectively investigated. Read More

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http://dx.doi.org/10.1186/s12957-020-01908-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320551PMC

Xiaoaiping injection as adjunct therapy for patients with advanced esophageal carcinoma: A protocol for a systematic review and meta-analysis.

Medicine (Baltimore) 2020 Jun;99(26):e20984

Department of General Surgery, People's Hospital of Weifang Binhai Economic and Technological Development Zone, Weifang, Shandong Province, China.

Background: Esophageal carcinoma (EC) is one of the worst malignant digestive neoplasms with a strong tendency of invasion and metastasis. Despite the improvement of diagnostic and therapeutic methods in the past decades, the prognosis of EC remains unsatisfactory. Xiaoaiping injection (XAPI), a famous traditional Chinese herbal medicine, has been widely applied as a promising adjunctive drug for EC. Read More

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http://dx.doi.org/10.1097/MD.0000000000020984DOI Listing

Serum exsomal miR-766-3p expression is associated with poor prognosis of esophageal squamous cell carcinoma.

Cancer Sci 2020 Jun 26. Epub 2020 Jun 26.

Department of Epidemiology and Health Statistics, Fujian Medical University Fujian, Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, 350122, China.

To analyze the association between exosomal miR-766-3p expression levels in the serum and the prognosis of esophageal squamous cell carcinoma (ESCC). The serum global exosomal microRNA expression of ESCC patients was measured by microRNA microarray. Quantitative real-time polymerase chain reactions (qRT-PCR) were used to analyze the expression levels of candidate microRNAs in both serum and tissues from ESCC patients. Read More

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http://dx.doi.org/10.1111/cas.14550DOI Listing

Treatment of esophageal cancer with multiple liver metastases: a case experience of sustained complete response.

J Int Med Res 2020 Jun;48(6):300060520935214

Department of Breast and Thyroid Surgery, Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University School of Medicine, Zhejiang, China.

Esophageal squamous cell cancer with distant metastases has a poor prognosis. The metastatic sites usually involve the liver, bones, and lungs. Treatment of metastatic disease is essentially palliative and based on chemoradiotherapy. Read More

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http://dx.doi.org/10.1177/0300060520935214DOI Listing

A chalcone inhibits the growth and metastasis of KYSE-4 esophageal cancer cells.

J Int Med Res 2020 Jun;48(6):300060520928831

Henan Medical College, Zhengzhou, Henan, China.

Objective: To investigate the and anticancer effects of a chalcone against KYSE-4 esophageal cancer cells.

Methods: A chalcone was synthesized via the molecular hybridization strategy based on the anticancer activity of chalcone and dithiocarbamate scaffolds. The anticancer effects of different concentrations of the chalcone derivative were compared in esophageal cancer cells. Read More

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http://dx.doi.org/10.1177/0300060520928831DOI Listing

Evaluating polygenic risk scores in assessing risk of nine solid and hematologic cancers in European descendants.

Int J Cancer 2020 Jun 25. Epub 2020 Jun 25.

Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Genome-wide association studies (GWAS) have identified many genetic risk variants for cancers. The utility of these variants in assessing risk of esophageal, gastric, and endometrial cancers, as well as melanoma, glioma, diffuse large B-cell lymphoma, follicular lymphoma, chronic lymphoid leukemia, and multiple myeloma, has not been adequately investigated. We constructed a site-specific polygenic risk score (PRS) for each of these nine cancers using their GWAS-identified risk variants. Read More

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http://dx.doi.org/10.1002/ijc.33176DOI Listing

ASO Author Reflections: Minimally Invasive Ivor-Lewis Esophagectomy for Esophageal Cancer After Gastric Bypass.

Ann Surg Oncol 2020 Jun 25. Epub 2020 Jun 25.

Department of Surgery, University of Florida College of Medicine, Jacksonville, FL, USA.

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http://dx.doi.org/10.1245/s10434-020-08756-4DOI Listing