Search Our Scientific Publications & Authors

Cancer Lett 2019 Feb 13. Epub 2019 Feb 13.

Institute of Precision Cancer Medicine and Pathology, And Department of Pathology, Jinan University Medical College, Guangzhou, China; Department of Immunotherapy and Tumor Tissue Bank, Affiliated Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China. Electronic address:

Evasion of apoptosis is a major contributing factor to the development of chemo- and radiotherapy resistance. Therefore, activation of non-apoptotic programmed cell death (PCD) could be an effective alternative against apoptosis-resistant cancers. In this study, we demonstrated in vitro and in vivo that metformin can induce pyroptosis, a non-apoptotic PCD, in esophageal squamous cell carcinoma (ESCC), a commonly known chemo-refractory cancer, especially at its advanced stages. Read More

Ann Thorac Surg 2019 Feb 13. Epub 2019 Feb 13.

Lung cancer center/Department of thoracic surgery, West China Hospital Sichuan University. No. 37 Guoxue Alley Chengdu 610041 China. Electronic address:

Surg Case Rep 2019 Feb 15;5(1):22. Epub 2019 Feb 15.

Department of Gastroenterological Surgery, Yokohama City University School of Medicine, Fukuura 3-9, Kanazawa, Yokohama, Kanagawa, 236-0004, Japan.

Background: The esophageal metastasis of breast cancer is rare. Moreover, it is extremely unusual for patients to experience the symptoms of esophageal metastasis during their lifetimes. We present a case of dysphagia caused by esophageal metastasis after a long interval following a primary mastectomy. Read More

Gastric Cancer 2019 Feb 15. Epub 2019 Feb 15.

Department of Epidemiology, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Centre, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.

Background: Mediterranean diet (MD) adherence has been associated with reduced risks of esophageal and gastric cancer (subtypes) in a limited number of studies. We prospectively investigated associations between MD adherence and risks of esophageal squamous cell carcinoma (ESCC), esophageal adenocarcinoma (EAC), gastric cardia adenocarcinoma (GCA), and gastric non-cardia adenocarcinoma (GNCA) in a Dutch cohort.

Methods: Analyses were conducted using data from the 120852 participants of the Netherlands Cohort Study (NLCS), who were aged between 55 and 69 years at enrollment. Read More

Cancer Immunol Immunother 2019 Feb 15. Epub 2019 Feb 15.

CureVac AG, Tübingen, Germany.

CV9201 is an RNActive-based cancer immunotherapy encoding five non-small cell lung cancer-antigens: New York esophageal squamous cell carcinoma-1, melanoma antigen family C1/C2, survivin, and trophoblast glycoprotein. In a phase I/IIa dose-escalation trial, 46 patients with locally advanced (n = 7) or metastatic (n = 39) NSCLC and at least stable disease after first-line treatment received five intradermal CV9201 injections (400-1600 µg of mRNA). The primary objective of the trial was to assess safety. Read More

Fed Pract 2015 Sep;32(9):38-40

Ms. is an acute care nurse practitioner, is the director of the Interprofessional Fellowship program in patient safety, and is the program leader of pathology and laboratory medicine, and all authors are affiliated with the Lung Cancer Collaborative, all at the Pittsburgh VA Healthcare System in Pennsylvania. Dr. Eibling is also a professor of otolaryngology and vice chair for education at the University of Pittsburgh.

A patient presented with esophageal adenocarcinoma, pulmonary small-cell carcinoma, and high-grade carcinoma, which is a rare occurrence that required a staged multidisciplinary approach to treatment. Read More

Gastroenterology 2019 Feb 12. Epub 2019 Feb 12.

Division of General Medical Sciences-Oncology. Electronic address:

Background & Aims: Esophageal adenocarcinoma (EAC) is resistant to standard chemoradiation treatments and few targeted therapies are available. We used large-scale tissue profiling and pharmacogenetic analyses to identify deregulated signaling pathways in EAC tissues that might be targeted to slow tumor growth or progression.

Methods: We collected 397 biopsy specimens from patients with EAC and non-malignant Barrett's esophagus (BE), with or without dysplasia. Read More

BMC Med Imaging 2019 Feb 15;19(1):17. Epub 2019 Feb 15.

Department of Diagnostic Radiology and Karolinska Institutet, Karolinska University Hospital, CLINTEC, Stockholm, Sweden.

Background: The clinical and research value of Computed Tomography (CT) volumetry of esophageal cancer tumor size remains controversial. Development in CT technique and image analysis has made CT volumetry less cumbersome and it has gained renewed attention. The aim of this study was to assess esophageal tumor volume by semi-automatic measurements as compared to manual. Read More

J Cell Biochem 2019 Feb 14. Epub 2019 Feb 14.

Department of Thoracic Surgery, Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu, China.

Increasing evidence have proved that long noncoding RNAs (lncRNAs) play significant roles in tumorigenesis and development of various cancers. However, the effect of small nucleolar RNA host gene 20 (SNHG20) on the progression of esophageal squamous cell carcinoma (ESCC) remains to be discovered. Herein, we aim to find out the function and the possible mechanism of SNHG20 in ESCC progression. Read More

Wideochir Inne Tech Maloinwazyjne 2019 Jan 30;14(1):133-136. Epub 2018 May 30.

Department of Gastroenterology, Chinese PLA 153 Hospital, Zhengzhou, China.

There are no previous reports of Mallory-Weiss tears occurring as complications during esophageal endoscopic submucosal dissection (ESD). We present 3 cases of Mallory-Weiss tears occurring during treatment of superficial squamous cell neoplasms through ESD. Carbon dioxide was used for air insufflation, and the patient was adequately sedated without retching or struggling during the operation. Read More

Wideochir Inne Tech Maloinwazyjne 2019 Jan 24;14(1):52-59. Epub 2018 Jul 24.

Department of Surgery I, Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czech Republic.

Introduction: Respiratory complications (RC) including respiratory failure and adult respiratory distress syndrome (ARDS) affect the outcomes of esophagectomy substantially. In order to decrease their incidence, identification of important features of RC is necessary.

Aim: To evaluate the incidence and risk factors of postoperative RC following hybrid esophagectomy. Read More

Gan To Kagaku Ryoho 2019 Jan;46(1):178-180

Dept. of Surgery, Tokyo Metropolitan Bokutoh Hospital.

A 72-year-old man with general fatigue was referred, and CT and MRI revealed a pancreatic mass with necrosis that was suspected of invading the stomach, splenic artery, celiac artery, liver, and portal vein. Upper gastrointestinal endoscopy showed an extrinsic mass with ulcer formation in the posterior wall of the upper gastric corpus and irregular mucosa in the lower esophagus incidentally. Biopsy showed squamous cell carcinoma from both lesions, leading to the diagnosis of pancreatic adenosquamous carcinoma and early esophageal cancer. Read More

Gan To Kagaku Ryoho 2019 Jan;46(1):91-93

Dept. of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences.

We examined the usefulness of radiotherapy for bone metastasis after esophageal cancer surgery. Between 2001 and 2016, we performed surgical resection for esophageal cancer in our department and 11 patients had postoperative bone metastases. Of these, 7 underwent radiotherapy. Read More

Gan To Kagaku Ryoho 2019 Jan;46(1):65-69

Dept. of Digestive Surgery, Saku Central Hospital Advanced Care Center.

A 69-year-old man with chronic gastritis, reflux esophagitis, esophageal hiatal hernia, and history of appendicitis surgery complained of difficulty swallowing. Upper gastrointestinal endoscopy revealed a 10 cm sized Type 3 gastric cancer. Immunostaining was positive for chromogranin A(2+), synaptophysin(3+), CD56(-), and Ki-67>70%. Read More

Gan To Kagaku Ryoho 2019 Jan;46(1):61-63

Dept. of Gastroenterological Surgery, Graduate School of Medical Science, Kanazawa University.

Docetaxel, cisplatin, and 5-FU(DCF)chemotherapy for esophageal cancer has been reported to be highly effective, but often causes serious adverse events, including severe bone marrow suppression. We report the successful treatment of a 67- year-old man with highly advanced esophageal cancer with invasion of the left bronchus and broad lymph node metastases. He received induction chemotherapy with DCF therapy, and prophylactic administration of pegfilgrastim. Read More

Surgery 2019 Feb 11. Epub 2019 Feb 11.

Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, Japan.

Background: Postoperative pneumonia can be a fatal complication that may occur after lung resection in cancer patients. Some reports have shown that the incidence of postoperative pneumonia is decreased after esophageal surgery by perioperative oral care; however, there exist no data to suggest that a lack of perioperative oral care can be a risk factor for postoperative pneumonia after lung resection. To investigate the association between the preventive effect of oral care and postoperative pneumonia, we conducted a multicenter, retrospective study of lung cancer patients who underwent lung resection. Read More

Cancers (Basel) 2019 Feb 5;11(2). Epub 2019 Feb 5.

Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.

Prediction models are only sparsely available for metastatic oesophagogastric cancer. Because treatment in this setting is often preference-based, decision-making with the aid of a prediction model is wanted. The aim of this study is to construct a prediction model, called SOURCE, for the overall survival in patients with metastatic oesophagogastric cancer. Read More

J Clin Med 2019 Feb 5;8(2). Epub 2019 Feb 5.

Department of Medical Research, MacKay Memorial Hospital, New Taipei City 25160, Taiwan.

Esophageal cancer prognosis remains poor in current clinical practice. We previously reported that moscatilin can induce apoptosis and mitotic catastrophe in esophageal cancer cells, accompanied by upregulation of polo-like kinase 1 (Plk1) expression. We aimed to validate in vitro activity and Plk1 expression in vivo following moscatilin treatment and to examine the treatment's radiosensitizing effect. Read More

Cancer Lett 2019 Feb 11. Epub 2019 Feb 11.

State Key Laboratory of Molecular Oncology, National Cancer Center/ National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, PR China. Electronic address:

Snail is an important transcription factor of epithelial-mesenchymal transition (EMT) and related to poor prognosis and distant metastasis of tumor patients. Snail is a liable protein and degraded by ubiquitin-proteasome system. There are various E3 ligases mediating its degradation, but the deubiquitinating enzyme reversed Snail degradation is not fully understood. Read More

J Control Release 2019 Feb 11. Epub 2019 Feb 11.

Department of Radiation Oncology, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA; Siteman Cancer Center, School of Medicine, Washington University in St. Louis, St. Louis, MO, USA. Electronic address:

Targeted molecular imaging allows specific visualization and monitoring of tumors. Cancer-specific peptides have been developed for imaging and therapy. Peptides that specifically target cancer have several advantages including, ease of synthesis, low antigenicity, and enhanced diffusion into tissues. Read More

Med Sci Monit 2019 Feb 14;25:1214-1219. Epub 2019 Feb 14.

Taixing People's Hospital Affiliated to Bengbu Medical College, Bengbu, Anhui, China (mainland).

BACKGROUND POU5F1B, serving as a carcinogen, participates in radiosensitivity of several tumors. However, in esophageal cancer, its potential mechanism and function in regulating radiosensitivity remain unclear. MATERIAL AND METHODS The expression level of POU5F1B was detected in plasma of esophageal tumor patients and cancer cell lines. Read More

Medicine (Baltimore) 2019 Feb;98(7):e14562

Department of Radiation Oncology, Shandong Provincial Qianfoshan Hospital affiliated to Shandong University, Jinan, Shandong, PR China.

NLR/Alb (neutrophil lymphocyte ratio/albumin ratio), is a prognostic index for esophageal cancer has been confirmed. Prealbumin (PA) is more sensitive to malnutrition than albumin. A new prognostic index, named neutrophil lymphocyte ratio/prealbumin ratio (NLR/PA), for predicting the survival time in patients with esophageal squamous cell carcinoma (ESCC) was proposed. Read More

Medicine (Baltimore) 2019 Feb;98(7):e14362

Department of Anesthesiology, The first affiliated hospital of Nanjing Medical University, Nanjing, 210029, China.

Background: Appropriate postoperative pain management can improve outcomes in patients with esophageal cancer (EC).

Objective: To compare different combinations of anesthesia and analgesia techniques in patients with EC undergoing open thoracotomy.

Methods: This randomized, controlled, open-label trial enrolled 100 patients with EC (aged 40-65 years; American Society of Anesthesiologists [ASA] grade I/II) receiving elective surgery at Jiangsu Province Hospital (China) between July 2016 and December 2017. Read More

J Gastrointest Cancer 2019 Feb 14. Epub 2019 Feb 14.

Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Purpose: Apoptosis is one of the main involved processes during development and organogenesis and its aberration may result in tumorigenesis. In the present study, due to the role of death inducer-obliterator 1 (DIDO1) in activation of caspases 9 and 3 during the apoptosis process, the role of DIDO1 as the shortest splicing variant of the DIDO gene was assessed for the first time in esophageal squamous cell carcinoma (ESCC) patients.

Methods: DIDO1 mRNA expression in tumor tissues from 50 ESCC patients was compared to their corresponding margin normal tissues using the real-time polymerase chain reaction (RT-PCR). Read More

J Gastrointest Surg 2019 Feb 13. Epub 2019 Feb 13.

Department of General Surgical Science, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, Maebashi, Gunma, 371-8511, Japan.

Background: Endoscopic submucosal dissection (ESD) of superficial esophageal cancer has been used increasingly as an alternative to surgery because it is minimally invasive and has a high rate of en bloc resection. We previously reported that the double endoscopic intraluminal operation (DEILO) is a useful technique for ESD of early esophageal cancers. In the current study, we showed comparable short-term data between DEILO and conventional ESD groups to demonstrate the further advanced use of DEILO. Read More

Mod Pathol 2019 Feb 13. Epub 2019 Feb 13.

Laboratory of Pathology, National Cancer Institute, National Institute of Health, Bethesda, MD, USA.

Primary malignant melanoma of esophagus is very rare, and its clinicopathologic and genetic features have not been extensively investigated. In this study, 20 tumors from 14 male and 6 female patients (40-79 years old) were evaluated. Dysphagia, chest pain, and weight loss were frequent symptoms. Read More

Eur J Case Rep Intern Med 2017 27;4(4):000597. Epub 2017 Feb 27.

Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan.

The case of an elderly man with an advanced oropharyngeal cancer that was missed during esophagogastroduodenoscopy is described. He was referred for endoscopic resection of superficial esophageal squamous cell neoplasms. He died a month after referral due to an advanced oropharyngeal cancer with a metastatic lesion to the brain. Read More

Abdom Radiol (NY) 2019 Feb 13. Epub 2019 Feb 13.

First Surgery University Clinic, Clinical Center of Serbia, Belgrade, Serbia.

Purpose: To evaluate the accuracy of the multidetector computed tomography (MDCT) in the response evaluation of the esophageal squamous cell carcinoma (ESCC) to neoadjuvant chemoradiotherapy (nCRT) by analyzing the thickness and post-contrast attenuation of the esophageal wall after the nCRT.

Methods: Contrast-enhanced (CE)-MDCT examinations in portal venous phase of one hundred patients with locally advanced ESCC who received nCRT and underwent esophageal resection and histopathology assessment of tumor regression grade (TRG) were retrospectively analyzed by measuring the maximal thickness and mean density of the esophageal wall in the segment involved by tumor and visually searching for hyperdense foci within it. Diagnostic performance was evaluated using the ROC analysis. Read More

Thorac Cancer 2019 Feb 12. Epub 2019 Feb 12.

Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.

Background: The effectiveness of treatments for recurrent esophageal squamous cell carcinoma (ESCC), particularly chemotherapy and chemoradiotherapy (CRT), remains unclear in patients who have previously been administered the same drugs during neoadjuvant chemotherapy.

Methods: In this retrospective study, 117 patients with recurrent thoracic ESCCs who had undergone curative resection were included. Patients were divided into two groups based on presurgical treatment: no presurgical treatment (n = 74), and neoadjuvant chemotherapy (n = 43). Read More

J Cell Biochem 2019 Feb 12. Epub 2019 Feb 12.

Cancer Hospital Affiliated of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, China.

Recent studies have demonstrated pleiotropic roles of pyruvate kinase isoenzyme type M2 (PKM2) in tumor progression. However, the precise mechanisms underlying the effects of PKM2 on esophageal squamous cell carcinoma (ESCC) metastasis and transforming growth factor β1 (TGF-β1)-induced epithelial-mesenchymal transition (EMT) remain to be established. In this study, we observed upregulation of PKM2 in ESCC tissues that was markedly associated with lymph node metastasis and poor prognosis. Read More

J Cancer Educ 2019 Feb 12. Epub 2019 Feb 12.

College of Health and Human Services, Northern Arizona University, Flagstaff, AZ, USA.

Native Americans experience cancer-related health disparities. Yet, little is known about the current cancer experience in one of the largest Native American tribe, Navajo. A qualitative study of among Navajo cancer survivors, in which focus groups and individual interviews included questions related to perceptions of cancer causes, prevention, and treatment, allowed us to evaluate several aspects of the cancer experience from the Navajo perspective. Read More

Am J Cancer Res 2019 1;9(1):79-93. Epub 2019 Jan 1.

Division of Pathology and Cell Therapy, Chiba Cancer Center Research Institute 666-2 Nitona, Chuo-ku, Chiba 260-8717, Japan.

Restoration of p53 functions is one of the therapeutic strategies for esophageal carcinoma which is often defective of the p53 pathway. We examined effects of CP-31398 which potentially increased expression of wild-type p53 or converted mutated p53 to the wild-type. We used 9 kinds of human squamous esophageal carcinoma cells with different genotypes and examined expression of p53 and the related molecules in CP-31398-treated cells. Read More

Cell Death Dis 2019 Feb 12;10(2):136. Epub 2019 Feb 12.

Department of Radiation Oncology, Second Affiliated Hospital, Xi'an Jiaotong University, 710004, Xi'an, China.

Resistance to radiotherapy results in relapse and treatment failure in locally advanced esophageal squamous cell carcinoma (ESCC). High mobility group box 1 (HMGB1) is reported to be associated with the radioresistance in bladder and breast cancer. However, the role of HMGB1 in the radiotherapy response in ESCC has not been fully elucidated. Read More

Carcinogenesis 2019 Feb 12. Epub 2019 Feb 12.

Sydney Brenner Institute for Molecular Bioscience, University of the Witwatersrand, Johannesburg, South Africa.

Oesophageal squamous cell carcinoma (OSCC) has a high incidence in southern Africa and a poor prognosis. Limited information is available on the contribution of genetic variants in susceptibility to OSCC in this region. However recent genome-wide association studies have identified multiple susceptibility loci in Asian and European populations. Read More

Mol Oncol 2019 Feb 12. Epub 2019 Feb 12.

Centre for Protein Science Design and Engineering, Indian Institute of Science Education and Research Mohali, Punjab-140306.

Cadherin-23 (Cdh23), a long chain non-classical cadherin, exhibits strong homophilic and heterophilic binding. The physiological relevance of strong heterophilic binding with protocadherin-15 at neuroepithelial tip links is well-studied. However, the role of Cdh23 homodimers in physiology is less understood, despite its widespread expression at the cell-boundaries of various human and mouse tissues, including kidney, muscle, testes, and heart. Read More

Int J Cancer 2019 Feb 12. Epub 2019 Feb 12.

State Key Laboratory of Bioelectronics, Southeast University, Nanjing, 210096, China.

Cell free DNA (cfDNA) in human plasma carries abundant information, which has therefore been the key sample for non-invasive prenatal testing (NIPT) and liquid biopsy. Especially by using the rapidly developed next-generation sequencing (NGS) techniques, the genetic and epigenetic information embedded in cfDNA has been effectively and extensively decoded. In this process, a key step is to construct the NGS library. Read More

World J Clin Cases 2019 Feb;7(3):291-299

Department of Cardiothoracic Surgery, Deyang People's Hospital, Deyang 618000, Sichuang Province, China.

Background: The main clinical treatment for esophageal cancer is surgery. Since traditional open esophageal cancer resection has the disadvantages of large trauma, long recovery period, and high postoperative complication rate, its clinical application is gradually reduced. The current report of minimally invasive Ivor-Lewis esophagectomy (MIILE) is increasing. Read More

World J Clin Cases 2019 Feb;7(3):260-269

Department of Surgery, Kuopio University Hospital, Kuopio 70029, Finland.

Background: Overexpression of heat shock proteins (HSPs) is associated with several malignancies and contributes to the development, progression, and metastasis of cancer, in addition to the inhibition of cellular death. In recent years, there has been active research into using HSP inhibitors in several malignancies. Due to the poor prognosis of esophageal adenocarcinoma (EAC), it would be valuable to find new biomarkers for the development of cancer treatments. Read More

J Thorac Dis 2018 Dec;10(12):6854-6862

Department of Surgery, Iwate Medical University School of Medicine, Iwate, Japan.

Background: Previous studies have shown that enteral nutrition (EN) helps reduce severe postoperative complications after esophagectomy. However, the incidence of jejunostomy-related complications is approximately 30%. We evaluated the operative outcomes in patients who did not receive EN via feeding jejunostomy after esophagectomy. Read More

J Thorac Dis 2018 Dec;10(12):6846-6853

Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.

Background: It is important to identify patients with esophageal squamous cell carcinoma (ESCC) in T1b stage that are the least likely to metastasize on the lymph nodes, to undergo endoscopic resection, especially for the patients unfit for esophagectomy. The relationship between endoscopic morphology and frequency of nodal metastasis has never been well studied. The aims of the study were to investigate the predictive value of endoscopic morphology for lymphatic metastasis, and to develop a risk stratification model in submucosal (T1b) ESCC. Read More

Br J Cancer 2019 Feb 12. Epub 2019 Feb 12.

Department of Oncology, Azienda Sanitaria Locale di Biella, Ponderano (BI), Italy.

Background: HER2 is the only validated predictive biomarker in gastro-oesophageal carcinoma (GOC). However, several factors, such as heterogeneity in protein expression, shortage of evaluable tumour tissue and need for quick target assessment, underline the usefulness of a pre-screening tool in order to anticipate HER2 status.

Methods: Data from 723 consecutive GOC analysed for HER2 at four Italian Institutions were collected. Read More

Nihon Shokakibyo Gakkai Zasshi 2019 ;116(2):138-144

Department of Gastroenterological Surgery, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences.

Nihon Shokakibyo Gakkai Zasshi 2019 ;116(2):129-137

Department of Radiation Oncology, Showa University School of Medicine.

Nihon Shokakibyo Gakkai Zasshi 2019 ;116(2):123-128

Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University.

Nihon Shokakibyo Gakkai Zasshi 2019 ;116(2):115-122

Gastrointestinal Medical Oncology Division, National Cancer Center Hospital.

Nihon Shokakibyo Gakkai Zasshi 2019 ;116(2):109-114

Department of Surgery, Keio University School of Medicine.

Development 2019 Feb 11. Epub 2019 Feb 11.

Division of Stem Cell Biology, Institute for Genetic Medicine, Hokkaido University, Sapporo 060-0815, Japan

The self-renewal activity of neural stem cells (NSCs) has been suggested to decrease with aging, resulting in age-dependent declines in brain function such as presbyopia and memory loss. The molecular mechanisms underlying decreases in NSC proliferation with age need to be elucidated in more detail to develop treatments that promote brain function. We previously reported that the expression of esophageal cancer-related gene 4 (Ecrg4) was up-regulated in aged NSCs, while its overexpression decreased NSC proliferation, suggesting a functional relationship between Ecrg4 and NSC aging. Read More

Clin Cancer Res 2019 Feb 11. Epub 2019 Feb 11.

Institute of Precision Cancer and Pathology, Department of Pathology, Jinan University Medical College

Purpose: Transcriptionally-induced chimeric RNAs are an important emerging area of research into molecular signatures for biomarker and therapeutic target development. Salivary exosomes represent a relatively unexplored but convenient and noninvasive area of cancer biomarker discovery. However, the potential of cancer-derived exosomal chimeric RNAs in saliva as biomarkers is unknown. Read More

Surgery 2019 Feb 8. Epub 2019 Feb 8.

Department of Surgery Western Health, The University of Melbourne, Melbourne, Australia.

Drugs 2019 Feb 11. Epub 2019 Feb 11.

Springer, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand.

Sintilimab (Tyvyt) is a fully human IgG4 monoclonal antibody that binds to programmed cell death receptor-1 (PD-1), thereby blocking the interaction of PD-1 with its ligands (PD-L1 and PL-L2) and consequently helping to restore the endogenous antitumour T-cell response. It has been co-developed by Innovent Biologics and Eli Lilly and Company, and was recently approved in China for the treatment of classical Hodgkin's lymphoma in patients who have relapsed or are refractory after ≥ 2 lines of systemic chemotherapy. Sintilimab is undergoing phase I, II and III development for use in various solid tumours, including non-small cell lung cancer and oesophageal cancer, in China. Read More