62,025 results match your criteria Esophageal Cancer


Rare pancreatic carcinosarcoma in a patient with medical history of esophageal cancer: A case report and literature review.

Medicine (Baltimore) 2019 Apr;98(16):e15238

Department of Pathology, Hebei General Hospital.

Rationale: Pancreatic carcinosarcoma (PCS) is a very rare pancreatic cancer with an extremely poor prognosis. Interestingly, PCS can coexist with other metachronous malignant cancers. Here we report a case of PCS combined with esophageal cancer (EC). Read More

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http://dx.doi.org/10.1097/MD.0000000000015238DOI Listing

Chronic Obstructive Pulmonary Disease and the Risk of Esophagitis, Barrett Esophagus, and Esophageal Adenocarcinoma: A Primary Care Case-Control Study.

J Clin Gastroenterol 2019 Apr 17. Epub 2019 Apr 17.

Sandwell General Hospital, West Bromwich, UK.

Background: Chronic gastroesophageal reflux predisposes to the development of esophageal adenocarcinoma (EAC). Asthma and medication to treat it are associated with gastroesophageal reflux and EAC. We studied subjects with chronic obstructive pulmonary disease (COPD) to examine the relationship between COPD and medication used to treat it, and the risk of reflux esophagitis, Barrett esophagus, and EAC. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001215DOI Listing

The addition of cetuximab to preoperative chemoradiotherapy for locally advanced esophageal squamous cell carcinoma is associated with high rate of long term survival: Mature results from a prospective phase Ib/II trial.

Radiother Oncol 2019 May 4;134:74-80. Epub 2019 Feb 4.

Institute of Oncology, Davidoff Cancer Center, Beilinson Hospital, Rabin Medical Center, Petach Tiqva, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Ramat Aviv, Tel-Aviv, Israel.

Aim: This phase IB/II study evaluated the safety and efficacy of the addition of cetuximab to standard preoperative chemoradiotherapy (CRT) in locally advanced esophageal cancer (LAEC).

Methods: Patients (pts) with resectable LAEC (TNM, TNM or TNM received an induction cycle of cisplatin 100 mg/m, day 1, and 5-fluorouracil (5-FU) 1000 mg/m/day, days 1-5, followed 4 weeks later by radiotherapy, 50.4 Gy, given with 2 cycles of cisplatin 75 mg/m and escalating doses of 5-FU, days 1-4 and 29-32. Read More

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http://dx.doi.org/10.1016/j.radonc.2019.01.013DOI Listing

Subclassification of skull-base invasion for nasopharyngeal carcinoma using cluster, network and survival analyses: A double-center retrospective investigation.

Radiother Oncol 2019 May 1;134:37-43. Epub 2019 Feb 1.

Department of Medical Imaging Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou 510060, PR China. Electronic address:

Purpose: To investigate the prognostic value of skull-base invasion (SBI) for nasopharyngeal carcinoma (NPC), propose a subclassification of SBI.

Methods: 792 and 433 patients with pathologically proven NPC and complete clinical and magnetic resonance imaging records at Sun Yat-sen University Cancer Center and Foshan Hospital were enrolled, and investigated using heat map/cluster, network and survival analyses.

Results: The results of heat map/cluster analyses and network analysis showed that T3 patients with pterygoid process and/or base of the sphenoid bone invasion (T3 slight) had better treatment outcomes than those with other SBIs (T3 severe). Read More

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http://dx.doi.org/10.1016/j.radonc.2019.01.021DOI Listing

Long-term results of a multicenter phase II study of preoperative chemoradiotherapy with S-1 plus oxaliplatin for locally advanced rectal cancer (JACCRO CC-04: SHOGUN Trial).

Radiother Oncol 2019 May 26;134:199-203. Epub 2019 Feb 26.

Japan Clinical Cancer Research Organization, Tokyo, Japan.

Purpose: The study was designed to evaluate the safety and efficacy of adding oxaliplatin to py (CRT) with S-1 in patients with locally advanced rectal carcinoma (LARC). We report here the final results of the study.

Patients And Methods: Patients with histopathologically confirmed LARC (cT3-T4, any N) were eligible. Read More

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http://dx.doi.org/10.1016/j.radonc.2019.02.006DOI Listing
May 2019
3 Reads

Indocyanine Green Fluorescence Imaging of the Tracheal Blood Flow During Esophagectomy.

J Surg Res 2019 Apr 17;241:1-7. Epub 2019 Apr 17.

Department of Digestive Surgery, Osaka International Cancer Institute, Chuo-ku, Osaka, Japan.

Background: Tracheobronchial ischemia and necrosis are uncommon causes of pulmonary complications that can be lethal on development. Surgical manipulation considering tracheal blood flow is important in radical esophagectomy with extensive lymph node dissection. This study introduces a novel method for assessing tracheal blood perfusion using indocyanine green (ICG) fluorescence imaging. Read More

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http://dx.doi.org/10.1016/j.jss.2019.03.019DOI Listing

NIR absorbing reduced graphene oxide for photothermal radiotherapy for treatment of esophageal cancer.

J Photochem Photobiol B 2019 Mar 22;194:188-193. Epub 2019 Mar 22.

Department of Radiotherapy, Linyi Cancer Hospital, Shandong, China. Electronic address:

Theranostic agents were drawing a huge attention in the personalized medication. In this study, we established a facile technique, plant extract-based technique for the synthesis of reduced nano-graphene oxide (RNGO) with low cytotoxicity. We formed platforms of photothermal (PT) therapy and further explained that the synthesized RNGO can be utilized as ready to use PT therapy without any additional surface adjustment. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10111344193020
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http://dx.doi.org/10.1016/j.jphotobiol.2019.03.014DOI Listing
March 2019
2 Reads

MDM2 copy number increase: A poor prognostic, molecular event in esophageal squamous cell carcinoma.

Hum Pathol 2019 Apr 17. Epub 2019 Apr 17.

Department of Diagnostic Pathology, Kobe University Graduate School of Medicine, Kobe, Japan; Institute of Liver Studies, King's College Hospital, London, UK. Electronic address:

The present study aimed to elucidate the clinicopathological significance of molecular alterations in MDM2 in esophageal squamous cell carcinoma (ESCC). A total of 399 resected cases of ESCC were examined by dual-color in situ hybridization (DISH) for MDM2 and immunohistochemistry for p53 using tissue microarrays. Clinicopathological features were correlated with the MDM2 status. Read More

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http://dx.doi.org/10.1016/j.humpath.2019.04.002DOI Listing

Dihydroartemisinin represses esophageal cancer glycolysis by down-regulating pyruvate kinase M2.

Eur J Pharmacol 2019 Apr 17. Epub 2019 Apr 17.

Department of Gastrointestinal Oncology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, 150081, PR China. Electronic address:

Esophageal cancer, especially esophageal squamous cell carcinoma (ESCC) threatens so many lives in China every year. Traditional treatment of ESCC has usually been disappointing. The development of novel therapy is worth investigation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00142999193024
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http://dx.doi.org/10.1016/j.ejphar.2019.04.018DOI Listing
April 2019
2 Reads

Predicting the Risk of Weight Loss After Esophageal Cancer Surgery.

Ann Surg Oncol 2019 Apr 19. Epub 2019 Apr 19.

Surgical Care Science, Department of Molecular medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Background: Malnutrition after esophageal cancer surgery is associated with reduced health-related qualify of life. Therefore, a prediction model identifying patients at risk for severe weight loss after surgery was developed.

Methods: Data from a Swedish population-based cohort study, including 616 patients undergoing esophageal cancer surgery in 2001-2005, was used. Read More

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http://dx.doi.org/10.1245/s10434-019-07352-5DOI Listing

Maspin differential expression patterns as a potential marker for targeted screening of esophageal adenocarcinoma/gastroesophageal junction adenocarcinoma.

PLoS One 2019 19;14(4):e0215089. Epub 2019 Apr 19.

Department of Oncology, Wayne State University School of Medicine, Detroit, United States of America.

Aim: Barrett's esophagus (BE) is a predisposing factor of esophageal adenocarcinoma/gastroesophageal junction adenocarcinoma (ECA/GEJ Aca). BE patients are stratified and subsequently monitored according to the risk of malignant progression by the combination of endoscopy and biopsy. This study is to evaluate the maspin expression patterns as early diagnostic markers of malignancy in BE patients. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215089PLOS

Single‑cell intratumoral stemness analysis reveals the involvement of cell cycle and DNA damage repair in two different types of esophageal cancer.

Oncol Rep 2019 Apr 15. Epub 2019 Apr 15.

Cancer Research Institute, Hangzhou Cancer Hospital, Hangzhou, Zhejiang 320000, P.R. China.

Intratumoral heterogeneity, particularly the potential cancer stemness of single cancer cells, has not yet been fully elucidated in human esophageal cancer. Single‑cell transcriptome sequencing of two types of esophageal adenocarcinoma (EAC) and two types of esophageal squamous cell carcinoma (ESCC) tissues was performed, and the intratumoral cancer stemness of the types of esophageal cancer were characterized at the single‑cell level in the present study. By comparing the transcriptomic profiles of single cancer cells with high and low stemness in individual patients, it was revealed that the overexpression of cell cycle‑associated genes in EAC cells was highly correlated with stemness, whereas overexpression of genes involved in the signaling pathways of DNA replication and DNA damage repair was significantly correlated with stemness in ESCC. Read More

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http://www.spandidos-publications.com/10.3892/or.2019.7117
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http://dx.doi.org/10.3892/or.2019.7117DOI Listing
April 2019
1 Read

MiRNA-485-5p, inhibits esophageal cancer cells proliferation and invasion by down-regulating O-linked N-acetylglucosamine transferase.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):2809-2816

Department of Radiation Oncology, Shandong University Affiliated Shandong Cancer Hospital and Institute, Jinan, Shandong Province, China.

Objective: Previous reports suggest that miRNA-485-5p is dysregulated and contributes to tumorigenesis in some cancer types. Nevertheless, the biological role of miRNA-485-5p in esophageal cancer (EC) is not well understood. Additionally, we found that the expression of miR-485-5p in EC tissues was aberrant. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17556DOI Listing

High-Resolution Genomic Alterations in Barrett's Metaplasia of Patients Who Progress to Esophageal Dysplasia and Adenocarcinoma.

Int J Cancer 2019 Apr 19. Epub 2019 Apr 19.

Department of Pathology and Cell Biology, Columbia University Irving Medical Center (CUIMC), New York, NY.

The main risk factor for esophageal dysplasia and adenocarcinoma (DAC) is Barrett's esophagus (BE), characterized by intestinal metaplasia. The critical genomic mechanisms that lead to progression of non-dysplastic BE to DAC remain poorly understood and require analyses of longitudinal patient cohorts and high-resolution assays. We tested BE tissues from 74 patients, including 42 non-progressors from two separate groups of 21 patients each, and 32 progressors (16 in a longitudinal cohort before DAC/pre-progression-BE, and 16 with temporally concurrent but spatially separate DAC/concurrent-BE). Read More

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http://dx.doi.org/10.1002/ijc.32351DOI Listing
April 2019
1 Read

Overexpression of FER1L4 promotes the apoptosis and suppresses epithelial-mesenchymal transition and stemness markers via activating PI3K/AKT signaling pathway in osteosarcoma cells.

Pathol Res Pract 2019 Apr 6. Epub 2019 Apr 6.

Department of Orthopaedics, Beijing Friendship Hospital, Capital Medical University, 100050, PR China.

Novel long non-coding RNA Fer-1-like protein 4 (FER1L4) has been identified as a tumor suppressor in endometrial carcinoma, ovarian cancer, hepatocellular carcinoma, esophageal squamous cell carcinoma. However, the function of FER1L4 in osteosarcoma has not been clear. The aim of the research was to explore the effects of FER1L4 in osteosarcoma. Read More

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http://dx.doi.org/10.1016/j.prp.2019.04.004DOI Listing

Swallowing Safety and Efficiency after Open Partial Horizontal Laryngectomy: A Videofluoroscopic Study.

Cancers (Basel) 2019 Apr 17;11(4). Epub 2019 Apr 17.

Head and Neck Oncology Service, Candiolo Cancer Institute-FPO IRCCS, Strada Provinciale 142 km 95, 10060 Candiolo (TO), Italy.

Dysphagia is common after an open partial horizontal laryngectomy (OPHL). The mechanisms causing lower airways' invasion and pharyngeal residue are unclear. The study aims to examine physio-pathological mechanisms affecting swallowing safety and efficiency after OPHL. Read More

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http://dx.doi.org/10.3390/cancers11040549DOI Listing

Association of wheat chaff derived silica fiber and esophageal cancer in north China.

Ecotoxicol Environ Saf 2019 Apr 15;178:79-85. Epub 2019 Apr 15.

School of Public Health, The University of Hong Kong, 7 Sassoon Road, Hong Kong SAR, China. Electronic address:

Background: Despite decades of research and intervention programs, the epidemic of esophageal squamous cell carcinoma (ESCC) in the Taihang Mountain area of north China has not seen convincing explanation by any risk factor yet and the incidence has not seen a substantial decrease. Based on recently disclosed association of aridity and wheat consumption with esophageal cancer, we revisited the hypothesis of biogenic silica in esophageal cancer development.

Methods: From the archives of the Pathology Department of Heping Hospital, Changzhi Medical College, we selected three pairs of formalin-fixed samples, tumor tissues and distant normal tissues, of three patients operated for ESCC who had no history of workplace exposure to silica dust. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01476513193045
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http://dx.doi.org/10.1016/j.ecoenv.2019.04.031DOI Listing
April 2019
2 Reads

Detecting pathological complete response in esophageal cancer after neoadjuvant therapy based on imaging techniques: a diagnostic systematic review and meta-analysis.

J Thorac Oncol 2019 Apr 15. Epub 2019 Apr 15.

Department of surgery.

Background: Up to 32% of patients with esophageal cancer show a pathological complete response (ypCR) after neoadjuvant therapy. In order to prevent overtreatment, the indication to perform esophagectomy in these patients should be reconsidered. Implementing an organ preserving strategy for patients with ypCR requires an accurate assessment of residual disease after neoadjuvant treatment. Read More

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http://dx.doi.org/10.1016/j.jtho.2019.04.004DOI Listing
April 2019
1 Read

High-fat Diet Accelerates Carcinogenesis in a Mouse Model of Barrett's Esophagus via IL8 and Alterations to the Gut Microbiome.

Gastroenterology 2019 Apr 15. Epub 2019 Apr 15.

Department of Internal Medicine, Technical University of Munich, Germany. Electronic address:

Background & Aims: Barrett's esophagus (BE) is a precursor to esophageal adenocarcinoma (EAC). Progression from BE to cancer is associated with obesity, possibly due to increased abdominal pressure and gastroesophageal reflux disease, although this pathogenic mechanism has not been proven. We investigated whether environmental or dietary factors associated with obesity contribute to progression of BE to EAC in mice. Read More

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http://dx.doi.org/10.1053/j.gastro.2019.04.013DOI Listing
April 2019
5 Reads

KLF4 activates NFκB signaling and esophageal epithelial inflammation via the Rho-related GTP-binding protein RHOF.

PLoS One 2019 18;14(4):e0215746. Epub 2019 Apr 18.

Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, United States of America.

Understanding the regulatory mechanisms within esophageal epithelia is essential to gain insight into the pathogenesis of esophageal diseases, which are among the leading causes of morbidity and mortality throughout the world. The zinc-finger transcription factor Krüppel-like factor (KLF4) is implicated in a large number of cellular processes, such as proliferation, differentiation, and inflammation in esophageal epithelia. In murine esophageal epithelia, Klf4 overexpression causes chronic inflammation which is mediated by activation of NFκB signaling downstream of KLF4, and this esophageal inflammation produces epithelial hyperplasia and subsequent esophageal squamous cell cancer. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215746PLOS
April 2019
1 Read

Impact of treatment planning using a structure block function on the target and organ doses related to patient movement in cervical esophageal cancer: A phantom study.

J Appl Clin Med Phys 2019 Apr 17. Epub 2019 Apr 17.

Department of Radiation Oncology, Aichi Cancer Center Hospital, Nagoya, Aichi, Japan.

Helical tomotherapy (HT) can restrict beamlets passing through the virtual contour on computed tomography (CT) image in dose optimization, reducing the dose to organs at risk (OARs). Beamlet restriction limits the incident beamlet angles; thus, the proper planning target volume (PTV) margin may differ from that of the standard treatment plan without beamlet restriction, depending on the patient's movement during dose delivery. Dose distribution changes resulting from patient movement have not been described for treatment plans with beamlet restriction. Read More

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http://dx.doi.org/10.1002/acm2.12582DOI Listing
April 2019
1 Read

Routine placement of feeding jejunostomy tube during esophagectomy increases postoperative complications and does not improve postoperative malnutrition.

Dis Esophagus 2019 Apr 17. Epub 2019 Apr 17.

Division of Gastrointestinal Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Hyogo, Japan.

Esophagectomy for esophageal cancer is a highly invasive procedure, and a feeding jejunostomy tube (FJT) is routinely placed to ensure adequate enteral nutrition. However, the effect of perioperative short-term FJT placement remains controversial, and the aim of this study was to assess risks and benefits of routine FJT placement during esophagectomy and to determine parameters that can identify patients needing long-term FJT. This retrospective study included 393 patients who had undergone esophagectomy with gastric tube reconstruction via the posterior mediastinal route at the Kobe University Hospital and the Hyogo Cancer Center between April 2010 and December 2017. Read More

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http://dx.doi.org/10.1093/dote/doz021DOI Listing
April 2019
1 Read

How many lymph nodes should be dissected in esophagectomy with or without neoadjuvant therapy to get accurate staging?

Dis Esophagus 2019 Apr 17. Epub 2019 Apr 17.

Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.

It is essential to dissect an adequate number of lymph nodes (LNs) to ensure staging accuracy during esophagectomy with or without neoadjuvant therapy. We developed a statistical model to quantify the probability of precise nodal staging based on previous studies. Esophageal cancer patients who underwent esophagectomy were retrospectively reviewed in the Surveillance, Epidemiology, and End Results database. Read More

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http://dx.doi.org/10.1093/dote/doz009DOI Listing

Clinical manifestation, risk factors and managements for postoperative chylothorax after thoracic esophagectomy.

J Thorac Dis 2019 Mar;11(Suppl 3):S198-S201

Division of Esophageal Surgery, National Cancer Center Hospital East, Kashiwa, Japan.

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http://dx.doi.org/10.21037/jtd.2019.02.31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424754PMC
March 2019
1 Read

Metal-free alkene carbooxygenation following tandem intramolecular alkoxylation/Claisen rearrangement: stereocontrolled access to bridged [4.2.1] lactones.

Chem Sci 2019 Mar 24;10(10):3123-3129. Epub 2019 Jan 24.

State Key Laboratory of Physical Chemistry of Solid Surfaces , Key Laboratory for Chemical Biology of Fujian Province , College of Chemistry and Chemical Engineering , Xiamen University , Xiamen 361005 , China . Email:

Alkene carbooxygenation has attracted considerable attention over the past few decades as this approach provides an efficient access to various oxygen-containing molecules, especially the valuable O-heterocycles. However, examples of catalytic alkene carbooxygenation a direct C-O cleavage are quite scarce, and the C-O cleavage in these cases is invariably initiated by transition metal-catalyzed oxidative addition. We report here a novel Brønsted acid-catalyzed intramolecular alkoxylation-initiated tandem sequence, which represents the first metal-free intramolecular alkoxylation/Claisen rearrangement. Read More

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http://dx.doi.org/10.1039/c9sc00079hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429610PMC
March 2019
1 Read

Retraction Note: Overexpression of A613T and G462T variants of DNA polymerase β weakens chemotherapy sensitivity in esophageal cancer cell lines.

Cancer Cell Int 2019 8;19:88. Epub 2019 Apr 8.

1School of Basic Medical Sciences, Zhengzhou University, No.100 Kexue Road, 450001 Zhengzhou, Henan China.

[This retracts the article DOI: 10.1186/s12935-016-0362-x.]. Read More

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http://dx.doi.org/10.1186/s12935-019-0814-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452508PMC
April 2019
1.989 Impact Factor

Temperature-responsive biometamaterials for gastrointestinal applications.

Sci Transl Med 2019 Apr;11(488)

Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

We hypothesized that ingested warm fluids could act as triggers for biomedical devices. We investigated heat dissipation throughout the upper gastrointestinal (GI) tract by administering warm (55°C) water to pigs and identified two zones in which thermal actuation could be applied: esophageal (actuation through warm water ingestion) and extra-esophageal (protected from ingestion of warm liquids and actuatable by endoscopically administered warm fluids). Inspired by a blooming flower, we developed a capsule-sized esophageal system that deploys using elastomeric elements and then recovers its original shape in response to thermal triggering of shape-memory nitinol springs by ingestion of warm water. Read More

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http://dx.doi.org/10.1126/scitranslmed.aau8581DOI Listing
April 2019
2 Reads

IL1RN Polymorphisms Are Associated with a Decreased Risk of Esophageal Cancer Susceptibility in a Chinese Population.

Chemotherapy 2019 Apr 17:1-8. Epub 2019 Apr 17.

Department of Radiotherapy, Shaanxi Provincial Cancer Hospital Affiliated to Medical College, Xi'an Jiaotong University, Xi'an, China,

Background: Recent evidence suggested that IL1RN (interleukin-1 receptor antagonist) polymorphisms increased the susceptibility to cancers. The present study aimed to evaluate whether IL1RN was related to esophageal cancer susceptibility in a Northwest Han Chinese population.

Methods: The case-control study was conducted on 384 esophageal cancer patients and 499 healthy controls. Read More

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http://dx.doi.org/10.1159/000496400DOI Listing

Management of adverse events related to endoscopic resection of esophageal and gastric neoplasms: Report of consensus meeting.

Dig Endosc 2019 Apr;31 Suppl 1:2-3

Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan.

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http://dx.doi.org/10.1111/den.13386DOI Listing
April 2019
1 Read

Management of adverse events related to endoscopic resection of upper gastrointestinal neoplasms: Review of the literature and recommendations from experts.

Dig Endosc 2019 Apr;31 Suppl 1:4-20

Department of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan.

Prevention therapy is recommended for lesions >1/2 of the esophageal circumference. Locoregional steroid injection is recommended for lesions >1/2-3/4 of the esophageal circumference and oral steroids are recommended for lesions >1/2 of the subtotal circumference. For lesions of the entire circumference, oral steroid combined with injection steroid is considered. Read More

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http://dx.doi.org/10.1111/den.13388DOI Listing
April 2019
2 Reads

Significance of Intramural Metastasis in Patients with Esophageal Squamous Cell Carcinoma: An Indicator of Aggressive Cancer Behavior.

World J Surg 2019 Apr 16. Epub 2019 Apr 16.

Department of Gastroenterological Surgery, Gastroenterology Center, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan.

Background: Intramural metastasis (IM) is occasionally noted in patients with esophageal squamous cell carcinoma (ESCC). However, few recent studies have investigated the clinicopathological characteristics of IM and its survival impact. The present study aimed to clarify the clinicopathological and prognostic significance of IM in patients with ESCC. Read More

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http://dx.doi.org/10.1007/s00268-019-05004-zDOI Listing
April 2019
1 Read

Role of MAML1 in targeted therapy against the esophageal cancer stem cells.

J Transl Med 2019 Apr 16;17(1):126. Epub 2019 Apr 16.

Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Esophageal cancer is the sixth-leading cause of cancer-related deaths worldwide. Cancer stem cells (CSCs) are the main reason for tumor relapse in esophageal squamous cell carcinoma (ESCC). The NOTCH pathway is important in preservation of CSCs, therefore it is possible to target such cells by targeting MAML1 as the main component of the NOTCH transcription machinery. Read More

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https://translational-medicine.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12967-019-1876-5DOI Listing
April 2019
2 Reads

Neoadjuvant versus definitive chemoradiation in patients with squamous cell carcinoma of the esophagus.

Radiat Oncol 2019 Apr 16;14(1):66. Epub 2019 Apr 16.

Department of Radiation Oncology, Klinikum rechts der Isar, Technical University Munich, Ismaninger Str. 22, 81675, Munich, Germany.

Background: Multimodal treatment with neoadjuvant chemoradiation followed by surgery (nCRT + S) is the treatment of choice for patients with locally advanced or node-positive esophageal squamous cell carcinoma (E-SCC). Those who are unsuitable or who decline surgery can be treated with definitive chemoradiation (dCRT). This study compares the oncologic outcome of nCRT + S and dCRT in E-SCC patients. Read More

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http://dx.doi.org/10.1186/s13014-019-1270-8DOI Listing

Correlation between the protein expression levels of A-kinase anchor protein95, p-retinoblastoma (Ser780), cyclin D2/3, and cyclin E2 in esophageal cancer tissues.

Asia Pac J Clin Oncol 2019 Apr 16. Epub 2019 Apr 16.

State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen Fujian, China.

Aim: This study aimed to investigate the correlation between the expression of A-kinase anchor protein95 (AKAP95), p-retinoblastoma (phosphorylated Rb, p-Rb), cyclin D2, cyclin D3 and cyclin E2 in esophageal cancer tissues and clinicopathological indexes.

Method: The protein expression levels of AKAP95, p-Rb, cyclin D2/3 and cyclin E2 in 40 esophageal cancer tissues were detected using immunohistochemistry, and the correlation between them was analyzed.

Result: The percentage of p-Rb (Ser780)-, cyclin D2-, cyclin D3- and cyclin E2-positive samples was 62. Read More

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http://dx.doi.org/10.1111/ajco.13146DOI Listing
April 2019
1 Read

Loss of G3BP1 suppresses proliferation, migration, and invasion of esophageal cancer cells via Wnt/β-catenin and PI3K/AKT signaling pathways.

J Cell Physiol 2019 Apr 15. Epub 2019 Apr 15.

Beijing International Science and Technology Cooperation Base of Antivirus Drug, College of Life Science and Bioengineering, Beijing University of Technology, Beijing, P. R. China.

Accumulating evidence suggests that Ras GTPase-activating protein SH3 domain-binding protein 1 (G3BP1) is very crucial to regulate tumorigenesis and metastasis. Recently, many research works have suggested that G3BP1 is overexpressed in many human cancers including esophageal cancer. Nevertheless, the functional roles of G3BP1 in esophageal cancer are still unknown. Read More

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http://dx.doi.org/10.1002/jcp.28648DOI Listing

Prevalence and Associated Impacts of Cervical Esophageal Clearance Issues Post Chemoradiotherapy for Nasopharyngeal Carcinoma (NPC).

Dysphagia 2019 Apr 15. Epub 2019 Apr 15.

School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, QLD, Australia.

At present, the nature and extent of upper esophageal stage clearance issues following nonsurgical management of nasopharyngeal cancer (NPC) is not well elucidated. The aim of this study was to conduct an initial retrospective study of the prevalence and severity of upper esophageal clearance impairments in a cohort of patients post-NPC management. A secondary aim was to explore any observed relationship between severity of impairment with both (a) aspiration and (b) temporal oropharyngeal swallowing measures. Read More

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http://dx.doi.org/10.1007/s00455-019-10007-yDOI Listing
April 2019
1 Read

Prognostic impact of cigarette smoking on the survival of patients with established esophageal squamous cell carcinoma receiving radiotherapy: A retrospective study from southern China.

Exp Ther Med 2019 May 7;17(5):3671-3681. Epub 2019 Mar 7.

Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510060, P.R. China.

Cigarette smoking is associated with the development of esophageal squamous cell carcinoma (ESCC); however, the influence of smoking on survival of patients with ESCC receiving radiotherapy, with or without chemotherapy, has remained elusive. The present study retrospectively analyzed 479 patients with ESCC from southern China who were categorized based on their smoking history (never, previous or current). To consider the cumulative effect of smoking, the number of pack years (PYs) was used as a representative variable. Read More

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http://dx.doi.org/10.3892/etm.2019.7356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447759PMC

Management of intrathoracic and cervical anastomotic leakage after esophagectomy for esophageal cancer: a systematic review.

World J Emerg Surg 2019 4;14:17. Epub 2019 Apr 4.

1Department of Surgery, Radboudumc, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, The Netherlands.

Background: Anastomotic leakage (0-30%) after esophagectomy is a severe complication and is associated with considerable morbidity and mortality. The aim of this study was to determine which treatment for anastomotic leakage after esophagectomy have the best clinical outcome, based on the currently available literature.

Methods: A systematic literature search was performed in Medline, Embase, and Web of Science until April 2017. Read More

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http://dx.doi.org/10.1186/s13017-019-0235-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449949PMC
April 2019
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Identification of prothymosin alpha (PTMA) as a biomarker for esophageal squamous cell carcinoma (ESCC) by label-free quantitative proteomics and Quantitative Dot Blot (QDB).

Clin Proteomics 2019 5;16:12. Epub 2019 Apr 5.

1Precision Medicine Research Center, Binzhou Medical University, No. 346 Guanhai Rd., Laishan District, Yantai, 264003 Shandong Province People's Republic of China.

Background: Esophageal cancer (EC) is one of the malignant tumors with a poor prognosis. The early stage of EC is asymptomatic, so identification of cancer biomarkers is important for early detection and clinical practice.

Methods: In this study, we compared the protein expression profiles in esophageal squamous cell carcinoma (ESCC) tissues and adjacent normal esophageal tissues from five patients through high-resolution label-free mass spectrometry. Read More

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https://clinicalproteomicsjournal.biomedcentral.com/articles
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http://dx.doi.org/10.1186/s12014-019-9232-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449931PMC
April 2019
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Identification of Novel Circulating MicroRNA Biomarkers for the Diagnosis of Esophageal Squamous Cell Carcinoma and Squamous Dysplasia.

Cancer Epidemiol Biomarkers Prev 2019 Apr 15. Epub 2019 Apr 15.

Epidemiology and Health Statistics, Capital Medical University

Background: Circulating microRNAs (miRNAs) have been identified as diagnostic biomarkers for esophageal squamous cell carcinoma (ESCC), but their efficacy in discovering early-stage ESCC is still unsatisfying. Esophageal squamous dysplasia (ESD) is the precursor lesion of ESCC. Notably, little is known about the role(s) of circulating miRNAs in identifying ESD. Read More

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http://dx.doi.org/10.1158/1055-9965.EPI-18-1199DOI Listing

Hsa_circ_0004370 promotes esophageal cancer progression through miR-1294/LASP1 pathway.

Biosci Rep 2019 Apr 15. Epub 2019 Apr 15.

Department of Thoracic Surgery, Fujian Medical University Union Hospital, fuzhou, China

Circular RNAs (circRNAs) formed by back-splicing play multiple roles in the occurrence and development of cancer. Here, we found that hsa_circ_0004370 was upregulated in both esophageal cancer (EC) tissues and cell lines. Loss function of hsa_circ_0004370 by si-RNA significantly suppressed proliferation and invasion and promoted apoptosis in both EC cell lines. Read More

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http://bioscirep.org/lookup/doi/10.1042/BSR20182377
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http://dx.doi.org/10.1042/BSR20182377DOI Listing
April 2019
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Slight advantages of nimotuzumab versus cetuximab plus concurrent chemoradiotherapy in locally advanced esophageal squamous cell carcinoma.

Cancer Biol Ther 2019 Apr 14:1-6. Epub 2019 Apr 14.

a Department of Radiation Oncology , Shandong Cancer Hospital Affiliated to Shandong University , Jinan , Shandong Province , China.

This study aimed to compare the efficacy of nimotuzumab (Nimo) versus cetuximab (C225) plus concurrent chemoradiotherapy (CCRT) in locally advanced esophageal squamous cell carcinoma (LA-ESCC). A total of 95 patients with LA-ESCC were retrospectively reviewed, including 65 in Nimo and 30 in C225. The results showed that the ORR in Nimo (61. Read More

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http://dx.doi.org/10.1080/15384047.2019.1598760DOI Listing
April 2019
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Brachytherapy in the Palliation of Oesophageal Cancer: Effective but Impractical?

Clin Oncol (R Coll Radiol) 2019 Apr 11. Epub 2019 Apr 11.

Clinical Effectiveness Unit, The Royal College of Surgeons of England, London, UK; Department of Health Services Research and Policy, London School of Hygiene & Tropical Medicine, London, UK.

Dysphagia in people with advanced oesophageal cancer can be treated by oesophageal stents, external beam radiotherapy (EBRT) and intraluminal brachytherapy. Despite guidelines recommending brachytherapy for patients with a predicted life expectancy exceeding 3 months, its uptake in the UK has been limited. Here we examine the strength of the evidence supporting the use of brachytherapy compared with oesophageal stents and EBRT and possible reasons for its limited uptake. Read More

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http://dx.doi.org/10.1016/j.clon.2019.03.045DOI Listing
April 2019
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Minichromosomal Maintenance Component Complex 5 (MCM5) as a Marker of Barrett's Esophagus-Related Neoplasia: A Feasibility Study.

Dig Dis Sci 2019 Apr 13. Epub 2019 Apr 13.

Division of Surgery and Interventional Science, University College London, London, UK.

Background: The endoscopic detection of esophageal cancer is suboptimal in both patients referred with dyspeptic symptoms and those enrolled in Barrett's surveillance programs. MCM5 expression in cells collected from gastric fluid may be correlated with the presence of dysplasia or adenocarcinoma. Analysis of this biomarker may improve the detection of cancer. Read More

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http://dx.doi.org/10.1007/s10620-019-05607-5DOI Listing

Overexpression of macrophage stimulating 1 enhances the anti-tumor effects of IL-24 in esophageal cancer via inhibiting ERK-Mfn2 signaling-dependent mitophagy.

Biomed Pharmacother 2019 Apr 10;114:108844. Epub 2019 Apr 10.

Department of Thoracic Surgery, Beijing Luhe Hospital, Capital Medical University, 82 Xinhua South Road, Tongzhou District, Beijing, 101149, PR China. Electronic address:

Although cytokine-based therapy is a promising tool to control the progression of esophageal cancer, low therapeutic responses largely compromise treatment efficacy through unidentified mechanisms. The goal of our study was to explore the roles of macrophage stimulating 1 (Mst1) and mitophagy in enhancing IL-24-based cytokine therapy in esophageal cancer. Our data demonstrated that IL-24 application promoted cancer death by inducing mitochondrial stress, as manifested by mitochondrial ROS overproduction, mitochondrial potential dissipation, cellular ATP deprivation and mitochondrial death activation. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108844DOI Listing
April 2019
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Anti-FIRΔexon2, a splicing variant form of PUF60, auto-antibody is detected in the sera of esophageal squamous cell carcinoma.

Cancer Sci 2019 Apr 13. Epub 2019 Apr 13.

Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.

Anti-PUF60 autoantibodies are reportedly detected in the sera of patients with dermatomyositis and Sjogren's syndrome; however, little is known regarding its existence in the sera of cancer patients. FIR, a splicing variant of the PUF60 gene, is a transcriptional repressor of c-myc. In colorectal cancer, there is an overexpression of the dominant negative form of FIR, in which exon 2 is lacking (FIRΔexon2). Read More

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http://dx.doi.org/10.1111/cas.14024DOI Listing
April 2019
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Evaluation of the impact of psoas muscle index, a parameter of sarcopenia, in patients with esophageal squamous cell carcinoma receiving neoadjuvant therapy.

Esophagus 2019 Apr 12. Epub 2019 Apr 12.

Department of Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan.

Background: The impact of sarcopenia on digestive cancer is widely known. Muscle mass, defined as the psoas muscle index (PMI), is an important parameter of sarcopenia. However, the relationship between esophageal cancer and PMI has not been fully investigated, especially in patients receiving neoadjuvant therapy. Read More

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http://dx.doi.org/10.1007/s10388-019-00670-3DOI Listing

Significance of the board-certified surgeon systems and clinical practice guideline adherence to surgical treatment of esophageal cancer in Japan: a questionnaire survey of departments registered in the National Clinical Database.

Esophagus 2019 Apr 12. Epub 2019 Apr 12.

The Japanese Society of Gastroenterological Surgery, 3-1-17 Axior Mita 6F, Minato-ku, Tokyo, 108-0073, Japan.

Background: It remains unknown how much institutional medical structure and process of implementation of clinical practice guidelines for esophageal cancers can improve quality of surgical outcome in Japan.

Methods: A web-based questionnaire survey was performed for departments registered in the National Clinical Database in Japan from October 2014 to January 2015. Quality indicators (QIs) including structure and process indicators (clinical practice guideline adherence) were evaluated on the risk-adjusted odds ratio for operative mortality (AOR) of the patients using registered cases in the database who underwent esophagectomy and reconstruction in 2013 and 2014. Read More

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http://dx.doi.org/10.1007/s10388-019-00672-1DOI Listing

Innovative fully robotic 4-arm Ivor Lewis esophagectomy for esophageal cancer (RAMIE4).

Dis Esophagus 2019 Apr 12. Epub 2019 Apr 12.

Department of General, Visceral and Transplant Surgery, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.

Nowadays robotic surgery is established for abdominal and thoracic surgery. It has been shown that complex procedures are feasible using robotic systems, e.g. Read More

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http://dx.doi.org/10.1093/dote/doz015DOI Listing
April 2019
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Comparison of long-term outcomes between esophagectomy and chemoradiotherapy after endoscopic resection of submucosal esophageal squamous cell carcinoma.

Dis Esophagus 2019 Apr 12. Epub 2019 Apr 12.

Department of Gastroenterological Surgery.

Esophagectomy represents the standard treatment strategy for superficial esophageal cancer diagnosed pathologically as submucosal disease (pT1b) following an endoscopic resection (ER). However, chemoradiotherapy (CRT) is expected to become an alternative treatment option. This study retrospectively compared the outcomes of patients who underwent ER of submucosal esophageal squamous cell carcinoma, and who received additional treatment in the form of surgery and CRT. Read More

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http://dx.doi.org/10.1093/dote/doz023DOI Listing
April 2019
1 Read