271 results match your criteria Esophageal Atresia Tracheoesophageal Fistula

Risk factors for prolonged mechanical ventilation in neonates following gastrointestinal surgery.

Transl Pediatr 2022 May;11(5):617-624

Division of Neonatology, The Hospital for Sick Children, Toronto, Ontario, Canada.

Background: Prolonged mechanical ventilation (MV) should be avoided in neonates. Noninvasive ventilation (NIV) can facilitate weaning from MV but has risks for patients immediately following foregut surgery due to the potential risk of anastomotic leak. We evaluated the risk factors for prolonged MV following intestinal surgery in neonates. Read More

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Social media communities for patients and families affected by congenital pediatric surgical conditions.

Pediatr Surg Int 2022 Jul 19;38(7):1047-1055. Epub 2022 May 19.

International Center for Colorectal and Urogenital Care, Division of Pediatric Surgery, Anschutz Medical Campus, Children's Hospital Colorado, 13213 E 16th Ave, Box 323, Aurora, CO, 80045, USA.

Background: Social media has become a means to allow individuals affected by rare diseases to connect with others. This study aimed to characterize the use of three popular social media platforms by individuals affected by common pediatric surgery index conditions.

Methods: A systematic search of Instagram, Facebook, and Twitter was performed using standardized terms for the following pediatric surgical conditions: anorectal malformation, biliary atresia, bronchopulmonary sequestration, congenital diaphragmatic hernia (CDH), congenital pulmonary airway malformation, duodenal atresia, esophageal atresia/tracheoesophageal fistula (EA/TEF), gastroschisis, Hirschsprung disease (HD), and omphalocele. Read More

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The largest report on thoracoscopic surgery for recurrent tracheoesophageal fistula after esophageal atresia repair.

J Pediatr Surg 2022 Mar 5. Epub 2022 Mar 5.

Department of Neonatal Surgery, Beijing Children's Hospital, National Center for Children's Health, Capital Medical University, Beijing 100045, China; Department of Neonatal Surgery, The Affiliated Children's Hospital of Nanchang University, Nanchang 330006, China.

Background: Although thoracoscopic surgery has become the routine surgical method for esophageal atresia/tracheoesophageal fistula (EA/TEF), thoracoscopic treatment for recurrent tracheoesophageal fistula (rTEF) is far from popularized.

Objectives: We aimed to explore the safety and efficacy of thoracoscopic treatment for rTEF with a large-cohort study.

Methods: We retrospectively analyzed the clinical characteristics and outcomes of 103 consecutive patients who underwent thoracoscopic surgery for rTEF by one surgeon after EA/TEF repair at two different institutions in China from 2014 to 2021. Read More

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Evaluation of minimally invasive surgical skills training: comparing a neonatal esophageal atresia/tracheoesophageal fistula model with a dry box.

Surg Endosc 2022 Mar 21. Epub 2022 Mar 21.

Department of Pediatric Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan.

Background: Pediatric surgeons require highly advanced minimally invasive surgical skills to perform rare and complex surgeries in a very vulnerable population. We developed a neonatal esophageal atresia (EA) model to improve thoracoscopic surgical skills. This study aimed to evaluate the concurrent validity of the model by undertaking pre- and post-training skills assessments in two groups of students with no prior experience performing minimally invasive surgery, using the EA model and a dry box (DB). Read More

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Thoracoscopic repair for esophageal pulmonary fistula after esophageal atresia repair.

J Pediatr Surg 2022 Feb 22. Epub 2022 Feb 22.

Department of Neonatal Surgery, National Center for Children's Health, Beijing Children Hospital, Capital Medical University, 56 Nanlishi Road, Beijing 100045, China. Electronic address:

Background: Esophageal pulmonary fistula is a special type of acquired tracheoesophageal fistula that occurs after esophageal atresia/tracheoesophageal fistula repair. Thoracotomy is the surgical repair method currently in use, but postoperative outcomes are unclear. Therefore, we aimed to explore the preliminary safety, effectiveness, and feasibility of thoracoscopic surgical repair of esophageal pulmonary fistula. Read More

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February 2022

Current outcomes of infants with esophageal atresia and tracheoesophageal fistula: A multicenter analysis.

J Pediatr Surg 2022 Jun 14;57(6):970-974. Epub 2022 Feb 14.

Boston Children's Hospital, Department of Surgery, Boston, MA, United States of America. Electronic address:

Objective: This study aims to quantify mortality rates and hospital lengths of stay (LOS) in neonates with esophageal atresia and tracheoesophageal fistula (EA/TEF), and to characterize the effects of birth weight (BW) and associated congenital anomalies upon these.

Methods: Data regarding patients with EA/TEF were prospectively collected (2013-2019) at 298 North American centers. The primary outcome was mortality and secondary outcome was LOS. Read More

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Incidence of and risk factors for perioperative blood transfusion in infants undergoing index pediatric surgery procedures.

J Pediatr Surg 2022 Jun 12;57(6):1067-1071. Epub 2022 Feb 12.

Division of Pediatric Surgery, Children's Hospital Colorado, Aurora, CO, United States; Department of Surgery, University of Colorado School of Medicine, Aurora, CO, United States.

Background: There is a paucity of data on the frequency of transfusion during pediatric surgery index cases and guidelines for pretransfusion testing, defined as type and screen and crossmatch testing, prior to operation are not standardized. This study aimed to determine the incidence of perioperative blood transfusions during index neonatal operations and identify risk factors associated with perioperative blood transfusion to determine which patients benefit from pretransfusion testing.

Methods: A retrospective review of infants who underwent index neonatal cases between 2013 and 2019 was performed. Read More

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Musculoskeletal deformities in children with congenital thoracic malformations: a population-based cohort study.

Pediatr Surg Int 2022 May 2;38(5):731-736. Epub 2022 Mar 2.

Department of Surgery, University of Manitoba, Division of Pediatric Surgery and Children's Hospital Research Institute of Manitoba, AE402-820 Sherbrook Street, Winnipeg, MB, R3A 1S1, Canada.

Purpose: It is unclear if musculoskeletal deformities observed in patients with congenital diaphragmatic hernia (CDH), congenital lung lesion (CLL) and esophageal atresia/tracheoesophageal fistula (EA/TEF) are associated with the anomaly or are a result of the surgery required to treat the anomaly. This study compared the prevalence of musculoskeletal deformities for: (1) children with congenital thoracic anomalies to controls; (2) CLL to EA/TEF both repaired via thoracotomy; and (3) CLL and EA/TEF to CDH repaired via laparotomy.

Methods: We performed a retrospective study of children with CLL, CDH or EA/TEF between 1990 and 2016. Read More

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The role of motion tracking in assessing technical skill acquisition using a neonatal 3D-printed thoracoscopic esophageal atresia/tracheo-esophageal fistula simulator.

J Pediatr Surg 2022 Jun 1;57(6):1087-1091. Epub 2022 Feb 1.

Symulus Limited, Christchurch, New Zealand.

Introduction: Acquiring the technical skills required for thoracoscopic repair of esophageal atresia with tracheo-esophageal fistula (EA/TEF) is challenging. A high-fidelity 3D-printed pediatric thoracoscopic EA/TEF simulator has been developed to address this issue. This study explored motion-tracking as an assessment tool to distinguish between surgeons of different expertise using the simulator. Read More

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First genome-wide association study of esophageal atresia identifies three genetic risk loci at , //, and .

HGG Adv 2022 Apr 25;3(2):100093. Epub 2022 Jan 25.

Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.

Esophageal atresia with or without tracheoesophageal fistula (EA/TEF) is the most common congenital malformation of the upper digestive tract. This study represents the first genome-wide association study (GWAS) to identify risk loci for EA/TEF. We used a European case-control sample comprising 764 EA/TEF patients and 5,778 controls and observed genome-wide significant associations at three loci. Read More

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Generation of three induced pluripotent stem cells lines from patients with esophageal atresia/tracheoesophageal fistula type C.

Stem Cell Res 2022 04 18;60:102711. Epub 2022 Feb 18.

Esophageal Development and Engineering Laboratory, Sainte-Justine Research Centre, Esophageal Atresia Clinic and Division of Pediatric Gastroenterology Hepatology and Nutrition, CHU Sainte Justine, 3715 Côte Sainte Catherine, Université de Montréal, H3T1C5 Montréal, QC, Canada. Electronic address:

Esophageal atresia/tracheoesophageal fistula (EA/TEF) is the most common congenital anomaly of the upper gastrointestinal tract affecting 1 in 3,000 which could stem from a developmental anomaly of the foregut. The cause is not fully understood. We generated three iPSC cell lines using peripheral blood mononuclear cells (PBMCs) from EA/TEF type C patients. Read More

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Operative Volume of Newborn Surgery in German University Hospitals: High Volume Versus Low Volume Centers.

Eur J Pediatr Surg 2022 Jan 13. Epub 2022 Jan 13.

Department of Paediatric Surgery and Paediatric Urology, University Hospital Frankfurt, Frankfurt/M., Germany.

Introduction:  Adequate patient volume is essential for the maintenance of quality, meaningful research, and training of the next generation of pediatric surgeons. The role of university hospitals is to fulfill these tasks at the highest possible level. Due to decentralization of pediatric surgical care during the last decades, there is a trend toward reduction of operative caseloads. Read More

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January 2022

Retrospective analysis of pneumothorax after repair of esophageal atresia/tracheoesophageal fistula.

BMC Pediatr 2021 12 3;21(1):543. Epub 2021 Dec 3.

Department of Neonatal Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, 100045, Beijing, China.

Background: To analyze the possible causes, treatment and outcomes of postoperative pneumothorax in patients with Gross type C esophageal atresia/tracheoesophageal fistula (EA/TEF).

Methods: Medical records of patients with Gross type C EA/TEF who were diagnosed and treated in Beijing Children's Hospital from January 2007 to January 2020 were retrospectively collected. They were divided into 2 groups according to whether postoperative pneumothorax occurred. Read More

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December 2021

Is Technical Expertise Necessary to Assess Technical Expertise? Let's Ask the Kids.

J Laparoendosc Adv Surg Tech A 2021 Dec 22;31(12):1363-1366. Epub 2021 Oct 22.

Canterbury District Health Board, Department of Paediatric Surgery, Christchurch, New Zealand.

Simulation has an increasing role in surgical training; however, using validated tools such as the Objective Structured Assessment of Technical Skills (OSATS) is time-consuming, which may be a potential barrier to simulation-based training. This study tests the hypothesis that assessors with technical expertise are necessary to objectively score a technical task. Three tasks, ring transfer, needle pass, and atresia cut, were performed using a synthetic thoracoscopic simulator for esophageal atresia/tracheoesophageal fistula. Read More

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December 2021

Efficacy and Safety of Endoscopic Esophageal Dilatation in Pediatric Patients with Esophageal Strictures.

Int J Pediatr 2021 24;2021:1277530. Epub 2021 Sep 24.

Public Health Department, Ministry of Health, Manama, Bahrain.

Materials And Methods: In this retrospective cross-sectional single center study, records of patients with esophageal strictures presented to the pediatric department, Salmaniya Medical Complex, Bahrain, in the period between 1995 and 2019 were reviewed. Demographic data, indications of endoscopic dilatations, the procedure success rate, and possible complications were assessed.

Results: Forty-six children were found to have esophageal strictures. Read More

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September 2021

Anesthetic management of thoracoscopic procedures in neonates: a retrospective analysis of 45 cases.

Transl Pediatr 2021 Aug;10(8):2035-2043

Department of Anesthesiology and Perioperative Medicine, Milton S. Hershey Medical Center, Penn State College of Medicine, Hershey, PA, USA.

Background: Advances in medical techniques and equipment have enabled the thoracoscopic repair of certain congenital abnormalities in neonates including congenital esophageal atresia/tracheoesophageal fistula (EA/TEF) and congenital diaphragmatic hernia (CDH). A retrospective analysis was conducted to examine the anesthetic management of neonates (7 days or younger) undergoing thoracoscopic surgery in our hospital department, and to determine the efficacy of anesthetic management in neonates.

Methods: Clinical data from 45 neonates who underwent thoracoscopic surgery in our hospital from December 2015 to March 2020 were retrospectively analyzed. Read More

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Esophageal atresia/tracheoesophageal fistula and proximal symphalangism in a patient with a NOG nonsense mutation.

Am J Med Genet A 2022 01 2;188(1):269-271. Epub 2021 Sep 2.

Department of Pediatrics, Madigan Army Medical Center, Tacoma, Washington, USA.

Esophageal atresia and tracheoesophageal fistula (EA/TEF) are relatively common malformations of the human foregut. The etiology remains incompletely understood with genetic causes identified in a small minority of affected patients. We present the case of a newborn with type C EA/TEF along with proximal symphalangism found to have a de novo NOG nonsense mutation. Read More

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January 2022

Comparative Effectiveness of Recurrent Laryngeal Nerve Monitoring Techniques in Pediatric Surgery.

Laryngoscope 2022 04 25;132(4):889-894. Epub 2021 Aug 25.

Department of Otolaryngology and Communication Enhancement, Boston Children's Hospital, Boston, Massachusetts, USA.

Objectives/hypothesis: The recurrent laryngeal nerve (RLN) is at risk during pediatric cervical, thoracic, and cardiac surgery. We aim to determine the feasibility and effectiveness of RLN monitoring techniques in all pediatric patients.

Study Design: Retrospective case series. Read More

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Quantifying Upper Aerodigestive Sequelae in Esophageal Atresia/Tracheoesophageal Fistula Neonates.

Laryngoscope 2022 03 9;132(3):695-700. Epub 2021 Aug 9.

Center for Surgical Outcomes Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, U.S.A.

Objectives: We examined rates of upper aerodigestive tract (UADT) procedures in a multi-institutional cohort of neonates with esophageal atresia/tracheoesophageal fistula (EA/TEF) to estimate secondary UADT pathology.

Methods: A retrospective cohort study was performed using a previously-validated population of patients with EA/TEF within the Pediatric Health Information System (PHIS) between 2007 and 2015. ICD-9/10-CM codes for aerodigestive procedures were examined from 2007 to 2020: 1) diagnostic direct laryngoscopy and/or bronchoscopy (DLB), 2) DLB with intervention, 3) tracheostomy, 4) gastrostomy, 5) fundoplication, 6) aortopexy, 7) laryngotracheoplasty, and 8) esophageal dilation. Read More

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Exome survey of individuals affected by VATER/VACTERL with renal phenotypes identifies phenocopies and novel candidate genes.

Am J Med Genet A 2021 12 2;185(12):3784-3792. Epub 2021 Aug 2.

Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

The acronym VATER/VACTERL refers to the rare nonrandom association of the following component features (CFs): vertebral defects (V), anorectal malformations (ARM) (A), cardiac anomalies (C), tracheoesophageal fistula with or without esophageal atresia (TE), renal malformations (R), and limb anomalies (L). For the clinical diagnosis, the presence of at least three CFs is required, individuals presenting with only two CFs have been categorized as VATER/VACTERL-like. The majority of VATER/VACTERL individuals displays a renal phenotype. Read More

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December 2021

Whether prophylactic intraoperative chest drain insertion in esophageal atresia-tracheoesophageal fistula is an evidence-based practice or just a prejudice: A systematic review and meta-analysis.

J Pediatr Surg 2021 Jul 8. Epub 2021 Jul 8.

Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi, India.

Background: Various controversial practices in the management of Esophageal atresia-tracheoesophageal fistula (EA-TEF) can be noticed among pediatric surgeons. Routine intraoperative chest drain (IOCD) insertion is often debated and lacks any concrete evidence. This meta-analysis aims to compare the postoperative outcomes among newborns with and without IOCD insertion. Read More

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[Effect of muscle relaxants on the prognosis of neonates with congenital esophageal atresia-tracheoesophageal fistula after surgery].

Zhongguo Dang Dai Er Ke Za Zhi 2021 Jul;23(7):735-738

Neonatal Center, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.

Objective: To summarize the experience in the application of muscle relaxants in the perioperative period in neonates with congenital esophageal atresia-tracheoesophageal fistula (EA-TEF).

Methods: A retrospective analysis was performed on the medical data of 58 previously untreated neonates with EA-TEF who were treated in the Neonatal Center of Beijing Children's Hospital, Capital Medical University from 2017 to 2019. The incidence rate of anastomotic leak was compared between the neonates receiving muscle relaxants for different durations after surgery (≤ 5 days and > 5 days). Read More

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Surgical treatment of esophageal atresia with lower tracheoesophageal fistula in an extremely preterm infant (510 g, 25 + 5 weeks): a case report.

J Med Case Rep 2021 Jul 12;15(1):361. Epub 2021 Jul 12.

Department of Pediatric Surgery, University Hospital Leipzig, University of Leipzig, Liebigstrasse 20a, 04103, Leipzig, Germany.

Background: The surgical management of esophageal atresia in extreme-low-birth-weight infants (< 1000 g) is challenging. We report on an extreme-low-birth-weight infant who was extremely preterm (510 g, 25 + 5 weeks) and of prenatally unknown Gross type C esophageal atresia.

Case Presentation: After resuscitation and intubation, the tracheoesophageal fistula was closed on the first day of life in the neonatal intensive care unit via an extrapleural approach using a titanium clip. Read More

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Tracheal trifurcation: new cases and review of the literature.

Pediatr Radiol 2021 Sep 28;51(10):1848-1855. Epub 2021 May 28.

Advanced Cardiovascular Imaging Unit-Department of Imaging, Bambino Gesù Children's Hospital, IRCCS, Rome, RM, Italy.

Background: Tracheal trifurcation is an uncommon and often unknown type of anomalous tracheobronchial arborization, characterized by three main bronchi originating at the level of the carina. Diagnosis is important due to its clinical implications.

Objective: To highlight the anatomical, clinical and diagnostic aspects of tracheal trifurcation by reporting our experience and reviewing the literature. Read More

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September 2021

Impact of preservation of the azygos vein during surgical repair of esophageal atresia-tracheoesophageal fistula (EA-TEF): a systematic review and meta-analysis.

Pediatr Surg Int 2021 Aug 27;37(8):983-989. Epub 2021 Apr 27.

Department of Pediatric Surgery, AIIMS, New Delhi, India.

Esophageal atresia-tracheoesophageal fistula (EA-TEF) is one of the common congenital anomalies occurring in newborns. Over the last eight decades, various technical modifications have been proposed in the surgical repair of EA-TEF. Preservation of azygos vein is one such modification that has gained considerable attention. Read More

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Prevalence of acid gastroesophageal reflux disease in infants with esophageal atresia/tracheoesophageal fistula.

Pediatr Res 2022 03 16;91(4):977-983. Epub 2021 Apr 16.

Univ. Lille, CHU Lille, INSERM U1286, Reference Center for Congenital Abnormalities of the Esophagus, Lille, France.

Background: Given the high prevalence and complication risks of acid gastroesophageal reflux (GERD) in the first months of life in infants with esophageal atresia, the ESPGHAN/NASPGHAN consensus statement recommends systematic treatment with proton pump inhibitors (PPIs) until the age of 1 year and checking for acid GERD thereafter. However, these recommendations have not been evaluated.

Methods: This prospective study was conducted from 2007 to 2016. Read More

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Risk Factors of Early Mortality and Morbidity in Esophageal Atresia with Distal Tracheoesophageal Fistula: A Population-Based Cohort Study.

J Pediatr 2021 Jul 2;234:99-105.e1. Epub 2021 Mar 2.

University Hospital of Clermont Ferrand, France.

Objective: To identify the risk factors for early mortality and morbidity in a population with distal esophageal atresia (EA)-tracheoesophageal fistula.

Study Design: Cohort study from a national register. Main outcomes and measures included early mortality, hospital length of stay (LoS), need for nutritional support at 1 year of age as a proxy measure of morbidity, and complications during the first year of life. Read More

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Effect of Posterior Tracheopexy on Risk of Recurrence in Children after Recurrent Tracheo-Esophageal Fistula Repair.

J Am Coll Surg 2021 05 5;232(5):690-698. Epub 2021 Feb 5.

Departments of General Surgery, Boston Children's Hospital, Boston, MA. Electronic address:

Background: A recurrent tracheo-esophageal fistula can complicate esophageal atresia and tracheo-esophageal fistula (TEF) repair in children. Therapeutic approaches and the rate of recurrence vary widely. Most reports are limited by small cohorts and short-term follow-up, and rates of re-recurrence are substantial, making it difficult to select the treatment of choice. Read More

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Thoracoscopic oesophageal atresia/tracheo-oesophageal fistula (OA/TOF) repair is associated with a higher stricture rate: a single institution's experience.

Pediatr Surg Int 2021 Mar 7;37(3):397-401. Epub 2021 Feb 7.

Department of Specialist Neonatal and Paediatric Surgery, Great Ormond Street Hospital, London, UK.

Purpose: Thoracoscopic OA/TOF repair was first described in 1999. Currently, less than 10% of surgeons routinely employ minimally access surgery. Our primary aim was to review our immediate-, early- and long-term outcomes with this technique compared with the open approach. Read More

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Experience of Minimally Invasive Surgery in Neonates with Congenital Malformations in a Tertiary Care Pediatric Hospital.

J Indian Assoc Pediatr Surg 2020 Nov-Dec;25(6):378-384. Epub 2020 Oct 27.

Neonatal Intensive Care Unit, Pediatric Hospital, 21 Century National Medical Center, Mexican Institute of Social Security (IMSS), Mexico City, México.

Aim: The aim of this study is to report the experience with minimally invasive surgery (MIS) in neonates with congenital malformations in a tertiary care pediatric hospital.

Materials And Methods: Design: descriptive study. All neonates undergoing MIS from 2013 to 2018 were included in the study. Read More

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October 2020