243 results match your criteria Esophageal Atresia Tracheoesophageal Fistula

Tracheal trifurcation: new cases and review of the literature.

Pediatr Radiol 2021 May 28. Epub 2021 May 28.

Advanced Cardiovascular Imaging Unit-Department of Imaging, Bambino Gesù Children's Hospital, IRCCS, Rome, RM, Italy.

Background: Tracheal trifurcation is an uncommon and often unknown type of anomalous tracheobronchial arborization, characterized by three main bronchi originating at the level of the carina. Diagnosis is important due to its clinical implications.

Objective: To highlight the anatomical, clinical and diagnostic aspects of tracheal trifurcation by reporting our experience and reviewing the literature. Read More

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Impact of preservation of the azygos vein during surgical repair of esophageal atresia-tracheoesophageal fistula (EA-TEF): a systematic review and meta-analysis.

Pediatr Surg Int 2021 Apr 27. Epub 2021 Apr 27.

Department of Pediatric Surgery, AIIMS, New Delhi, India.

Esophageal atresia-tracheoesophageal fistula (EA-TEF) is one of the common congenital anomalies occurring in newborns. Over the last eight decades, various technical modifications have been proposed in the surgical repair of EA-TEF. Preservation of azygos vein is one such modification that has gained considerable attention. Read More

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Prevalence of acid gastroesophageal reflux disease in infants with esophageal atresia/tracheoesophageal fistula.

Pediatr Res 2021 Apr 16. Epub 2021 Apr 16.

Univ. Lille, CHU Lille, INSERM U1286, Reference Center for Congenital Abnormalities of the Esophagus, Lille, France.

Background: Given the high prevalence and complication risks of acid gastroesophageal reflux (GERD) in the first months of life in infants with esophageal atresia, the ESPGHAN/NASPGHAN consensus statement recommends systematic treatment with proton pump inhibitors (PPIs) until the age of 1 year and checking for acid GERD thereafter. However, these recommendations have not been evaluated.

Methods: This prospective study was conducted from 2007 to 2016. Read More

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Thoracoscopic oesophageal atresia/tracheo-oesophageal fistula (OA/TOF) repair is associated with a higher stricture rate: a single institution's experience.

Pediatr Surg Int 2021 Mar 7;37(3):397-401. Epub 2021 Feb 7.

Department of Specialist Neonatal and Paediatric Surgery, Great Ormond Street Hospital, London, UK.

Purpose: Thoracoscopic OA/TOF repair was first described in 1999. Currently, less than 10% of surgeons routinely employ minimally access surgery. Our primary aim was to review our immediate-, early- and long-term outcomes with this technique compared with the open approach. Read More

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Experience of Minimally Invasive Surgery in Neonates with Congenital Malformations in a Tertiary Care Pediatric Hospital.

J Indian Assoc Pediatr Surg 2020 Nov-Dec;25(6):378-384. Epub 2020 Oct 27.

Neonatal Intensive Care Unit, Pediatric Hospital, 21 Century National Medical Center, Mexican Institute of Social Security (IMSS), Mexico City, México.

Aim: The aim of this study is to report the experience with minimally invasive surgery (MIS) in neonates with congenital malformations in a tertiary care pediatric hospital.

Materials And Methods: Design: descriptive study. All neonates undergoing MIS from 2013 to 2018 were included in the study. Read More

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October 2020

Long-term respiratory complications of OA-TOF: The need for better data and a more specialized multidisciplinary approach.

Pediatr Pulmonol 2021 02 27;56(2):317-318. Epub 2020 Nov 27.

Department of Paediatric Respiratory Medicine, Alder Hey Children's Hospital NHS Foundation Trust, Liverpool, UK.

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February 2021

Esophageal atresia and tracheoesophageal fistula associated with tetralogy of Fallot: a review of mortality.

Pediatr Surg Int 2020 Oct 24;36(10):1243-1247. Epub 2020 Aug 24.

Department of Paediatric Surgery, Alder Hey Children's Hospital NHS Foundation Trust, University of Liverpool, Liverpool, UK.

Introduction: Oesophageal atresia ± tracheoesophageal fistula (EA/TEF) associated with congenital heart disease (CHD) carries a worse prognosis than EA/TEF alone. Though the Spitz classification takes major CHD into account, there are no data regarding survival with the specific combination of EA/TEF and Tetralogy of Fallot (TOF). With advances in postnatal care, we hypothesised that, survival is improving in these complex patients. Read More

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October 2020

Care of the COVID-19 exposed complex newborn infant.

Semin Perinatol 2020 11 21;44(7):151282. Epub 2020 Jul 21.

Division of Neonatology, NewYork-Presbyterian/Morgan Stanley Children's Hospital, Columbia University Irving Medical Center, New York, NY.

As we confront COVID-19, the global public health emergency of our times, new knowledge is emerging that, combined with information from prior epidemics, can provide insights on how to manage this threat in specific patient populations. Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS), both caused by coronaviruses, caused serious respiratory illness in pregnant women that resulted in adverse perinatal outcomes. Thus far, COVID-19 appears to follow a mild course in the vast majority of pregnant women. Read More

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November 2020

H-type congenital tracheoesophageal fistula: Insights from 70 years of The Royal Children's Hospital experience.

J Pediatr Surg 2021 Apr 11;56(4):686-691. Epub 2020 Jul 11.

Department of Paediatric Surgery, The Royal Children's Hospital, 50 Flemington Road, Parkville, VIC 3052, Australia; F. Douglas Stephens Surgical Research Group, Murdoch Children's Research Institute, 50 Flemington Road, Parkville, VIC 3052, Australia; Department of Paediatrics, The University of Melbourne, Parkville, VIC 3010, Australia.

Background: The long-term outcomes of H-type tracheoesophageal fistula (TOF), an uncommon variant of esophageal atresia/tracheoesophageal fistula (OA/TOF), are rarely described in the literature. We reviewed our institutional experience of 70 years.

Methods: The Nate Myers Oesophageal Atresia Database was queried for patients with an H-type TOF (1948-2017). Read More

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Care recommendations for the respiratory complications of esophageal atresia-tracheoesophageal fistula.

Pediatr Pulmonol 2020 10 7;55(10):2713-2729. Epub 2020 Aug 7.

Pediatrics, Division of Respirology, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, Canada.

Tracheoesophageal fistula (TEF) with esophageal atresia (EA) is a common congenital anomaly that is associated with significant respiratory morbidity throughout life. The objective of this document is to provide a framework for the diagnosis and management of the respiratory complications that are associated with the condition. As there are no randomized controlled studies on the subject, a group of experts used a modification of the Rand Appropriateness Method to describe the various aspects of the condition in terms of their relative importance, and to rate the available diagnostic methods and therapeutic interventions on the basis of their appropriateness and necessity. Read More

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October 2020

Novel candidate genes in esophageal atresia/tracheoesophageal fistula identified by exome sequencing.

Eur J Hum Genet 2021 Jan 8;29(1):122-130. Epub 2020 Jul 8.

Department of Pediatrics, Columbia University Medical Center, New York, NY, USA.

The various malformations of the aerodigestive tract collectively known as esophageal atresia/tracheoesophageal fistula (EA/TEF) constitute a rare group of birth defects of largely unknown etiology. Previous studies have identified a small number of rare genetic variants causing syndromes associated with EA/TEF. We performed a pilot exome sequencing study of 45 unrelated simplex trios (probands and parents) with EA/TEF. Read More

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January 2021

Genetic Mouse Models and Induced Pluripotent Stem Cells for Studying Tracheal-Esophageal Separation and Esophageal Development.

Stem Cells Dev 2020 08 2;29(15):953-966. Epub 2020 Jul 2.

Esophageal Development and Engineering Laboratory, Sainte-Justine Research Centre, Montreal, Quebec, Canada.

Esophagus and trachea arise from a common origin, the anterior foregut tube. The compartmentalization process of the foregut into the esophagus and trachea is still poorly understood. Esophageal atresia/tracheoesophageal fistula (EA/TEF) is one of the most common gastrointestinal congenital defects with an incidence rate of 1 in 2,500 births. Read More

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Human exome and mouse embryonic expression data implicate ZFHX3, TRPS1, and CHD7 in human esophageal atresia.

PLoS One 2020 5;15(6):e0234246. Epub 2020 Jun 5.

Center of Pediatric Surgery Hannover, Hannover Medical School, Hannover, Germany.

Introduction: Esophageal atresia with or without tracheoesophageal fistula (EA/TEF) occurs approximately 1 in 3.500 live births representing the most common malformation of the upper digestive tract. Only half a century ago, EA/TEF was fatal among affected newborns suggesting that the steady birth prevalence might in parts be due to mutational de novo events in genes involved in foregut development. Read More

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Scoliosis after thoracotomy repair of esophageal atresia: a systematic review.

Pediatr Surg Int 2020 Jul 25;36(7):755-761. Epub 2020 May 25.

Department of Paediatric Surgery, Wellington Children's Hospital, Riddiford Street, Newtown, Wellington, 6021, New Zealand.

Standard surgical repair of esophageal atresia/tracheoesophageal fistula (EA/TEF) is via a right posterolateral thoracotomy. A recognized complication is the later development of scoliosis. The prevalence and pathogenesis of secondary scoliosis are poorly understood. Read More

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Efficacy of a standardized tube weaning program in pediatric patients with feeding difficulties after successful repair of their esophageal atresia/tracheoesophageal fistula.

Eur J Pediatr 2020 Nov 15;179(11):1729-1737. Epub 2020 May 15.

Department of Paediatrics and Adolescent Medicine, Division of General Pediatrics, Medical University of Graz, Auenbruggerplatz 34/2, 8010, Graz, Austria.

Children born with esophageal atresia (EA) might suffer from significant oral feeding problems which could evolve into tube dependency. The primary aim of the study was to define the outcome of tube weaning in children after successful EA repair and to compare outcomes in children with short gap/TEF (tracheoesophageal fistula) and long-gap EA. Data of 64 children (28 with short-gap EA/TEF with primary anastomosis and 36 with long-gap EA with delayed surgical repair) who participated in a standardized tube weaning program based on the "Graz model of tube weaning" (in/outpatients in an intensive 3-week program, online coaching (Netcoaching) only, or a combined 2-week intensive onsite followed by online treatment "Eating School") from 2009 to 2019 was evaluated. Read More

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November 2020

The value of prophylactic chest tubes in tracheoesophageal fistula repair.

Pediatr Surg Int 2020 Jun 6;36(6):687-696. Epub 2020 May 6.

Division of Pediatric Surgery, The Saban Research Institute, Children's Hospital Los Angeles, 4650 Sunset Blvd., Mailstop #100, Los Angeles, CA, 90027, USA.

Purpose: Intraoperative chest tubes (IOCTs) can be placed during esophageal atresia/tracheoesophageal fistula (EA/TEF) repair to control pneumothoraces and detect esophageal leaks, potentially preventing the need for postoperative chest tubes (POCTs). However, data are lacking regarding IOCTs' effect. We hypothesized that IOCT placement would not reduce the risk of POCT placement and would increase hospital length of stay (LOS). Read More

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End-User Input into the Design and Validation of a Synthetic Thoracoscopic Esophageal Atresia/Tracheo-Esophageal Fistula Simulator.

J Laparoendosc Adv Surg Tech A 2020 Jun 28;30(6):685-691. Epub 2020 Apr 28.

Department of Paediatric Surgery, Christchurch Hospital, Christchurch, New Zealand.

Thoracoscopic repair of esophageal atresia and tracheo-esophageal fistula (EA/TEF) is challenging. We addressed this by designing a fully synthetic simulator of the procedure and described the design process and how its content validity was assessed. An iterative design and assessment of content validity was undertaken in three stages. Read More

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Patterns of malformation associated with esophageal atresia/tracheoesophageal fistula: A retrospective single center study.

Am J Med Genet A 2020 06 6;182(6):1351-1363. Epub 2020 Apr 6.

Department of Pediatrics, Division of Genetics and Dysmorphology, UC San Diego/Rady Children's Hospital, San Diego, California.

Esophageal atresia/tracheoesophageal fistula (EA/TEF) is one of the most common gastrointestinal birth defects. It can occur in isolation or in association with other birth defects or genetic syndromes. We retrospectively reviewed the EA/TEF cases evaluated at Rady Children's Hospital San Diego (San Diego, CA) between 2007 and 2016. Read More

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Impact of consolidation of cases on post-operative outcomes for index pediatric surgery cases.

J Pediatr Surg 2020 Jun 25;55(6):1048-1052. Epub 2020 Feb 25.

University of Utah, Department of Surgery, Division of Pediatric Surgery, Salt Lake City, UT.

Background: The effect of the consolidation of neonatal pediatric surgical cases to limited surgeons within a hospital is unknown. We elected to model the distribution of complex neonatal procedures using an economic measure of market concentration, the Herfindahl-Hirschmann Index (HHI), and study its effect on outcomes of index pediatric surgical operations.

Methods: We used data from 49 US children's hospitals between 2007 and 2017 for the following procedures: congenital diaphragmatic hernia repair (CDH), esophageal atresia and tracheoesophageal fistula repair (EA/TEF), and pull-through for Hirschsprung disease (HD). Read More

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Magnamosis for esophageal atresia is associated with anastomotic strictures requiring an increased number of dilatations.

J Pediatr Surg 2020 May 30;55(5):821-823. Epub 2020 Jan 30.

Departments of Surgery, Division of Pediatric Surgery, Pediatrics and Child Health, Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, Manitoba, Canada. Electronic address:

Background/purpose: Magnamosis is a novel technique which utilizes high power magnets to anastomose the esophageal ends in children with esophageal atresia (EA) with or without a tracheoesophageal fistula (TEF), theoretically avoiding the need for thoracotomy. The objective of this study was to compare anastomotic stricture formation requiring dilatation after magnamosis versus after conventional anastomosis.

Methods: Our center treated the first 3 cases of EA ± TEF with magnamosis in Canada. Read More

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Nationwide analysis of mortality and hospital readmissions in esophageal atresia.

J Pediatr Surg 2020 May 12;55(5):824-829. Epub 2020 Feb 12.

Dewitt-Daughtry Family Department of Surgery, Division of Pediatric Surgery, University of Miami Miller School of Medicine. Electronic address:

Purpose: The purpose of this study is to identify determinants of mortality and hospital readmission in infants born with esophageal atresia ± tracheoesophageal fistula.

Methods: The Nationwide Readmissions Database (2010-2014) was queried for newborns with a diagnosis of esophageal atresia. Outcomes included mortality and readmissions at 30-day and 1-year. Read More

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Outcome of thoracoscopic repair of type-C esophageal atresia: a single-center experience from North Africa.

Dis Esophagus 2020 Feb 12. Epub 2020 Feb 12.

Pediatric Surgical Department, Cairo University Specialized Pediatric Hospital, Cairo, Egypt.

Thoracoscopic repair of esophageal atresia is gaining popularity worldwide attributable to availability and advances in minimally invasive instruments. In this report, we presented our experience with thoracoscopic esophageal atresia/tracheoesophageal fistula (EA/TEF) repair in our tertiary care institute. A prospective study on short-gap type-C EA/TEF was conducted at Cairo University Specialized Pediatric Hospital between April 2016 and 2018. Read More

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February 2020

Gastrointestinal diseases among relatives of patients with esophageal atresia with or without tracheoesophageal fistula.

Transl Pediatr 2019 Dec;8(5):378-382

Department of Neonatology and Pediatric Intensive Care, Children's Hospital, University of Bonn, Bonn, Germany.

Background: Several studies have identified genetic factors that are associated with the formation of isolated and non-isolated esophageal atresia with or without tracheoesophageal fistula (EA/TEF) in human and mice. Some of these genetic factors like FOXF1/Foxf1 are associated with Barrett syndrome, esophageal carcinoma or tumors of the gastrointestinal tract. Here, we investigated the prevalence of common gastrointestinal diseases among EA/TEF patients and their first- and second-degree relatives (parents and grandparents). Read More

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December 2019

Development of an instrumented thoracoscopic surgical trainer for objective evaluation of esophageal atresia/tracheoesophageal fistula repair.

Med Biol Eng Comput 2020 Mar 11;58(3):601-609. Epub 2020 Jan 11.

Department of Paediatric Surgery, Christchurch Hospital, Christchurch, New Zealand.

Operative repair of complex conditions such as esophageal atresia and tracheoesophageal fistula (EA/TEF) is technically demanding, but few training opportunities exist outside the operating theater for surgeons to attain these skills. Learning them during surgery on actual neonates where the stakes are high, margins for error narrow, and where outcomes are influenced by technical expertise, is problematic. There is an increasing demand for high-fidelity simulation that can objectively measure performance. Read More

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Ultrashort Echo-Time MRI for the Assessment of Tracheomalacia in Neonates.

Chest 2020 03 17;157(3):595-602. Epub 2019 Dec 17.

Departments of Pediatrics & Radiology, University of Cincinnati, College of Medicine, Cincinnati, OH; Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Background: Bronchoscopy is the gold standard for evaluating tracheomalacia; however, reliance on an invasive procedure limits understanding of normal airway dynamics. Self-gated ultrashort echo-time MRI (UTE MRI) can assess tracheal dynamics but has not been rigorously evaluated.

Methods: This study was a validation of UTE MRI diagnosis of tracheomalacia in neonates using bronchoscopy as the gold standard. Read More

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Pediatric Esophageal Dilatations: A Cross-Specialty Experience.

J Laparoendosc Adv Surg Tech A 2020 Feb 3;30(2):206-209. Epub 2019 Dec 3.

Department of Paediatric Surgery, Evelina London Children's Hospital, London, United Kingdom.

Esophageal dilatations are commonly performed in pediatric patients who have undergone an esophageal atresia/tracheoesophageal fistula (EA/TEF) repair or following caustic injury. We sought to compare the practice of esophageal dilatation across different specialties. We analyzed all patients who had an esophageal dilatation at our center between April 2014 and December 2018. Read More

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February 2020

Congenital bronchopulmonary foregut malformation: systematic review of the literature.

BMC Pediatr 2019 09 2;19(1):305. Epub 2019 Sep 2.

Department of Pediatric Surgery, West China Hospital, Sichuan University, Guoxue Xiang No.37, Chengdu, 610041, China.

Background: Congenital bronchopulmonary foregut malformation (CBPFM) is a rare congenital malformation involving both the digestive and respiratory system. Early diagnosis is difficult, and delayed recognition may result in considerable complications. The aim of the study was to identify and analyze the clinical characteristics and radiological features of CBPFMs. Read More

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September 2019

Likelihood of meeting defined VATER/VACTERL phenotype in infants with esophageal atresia with or without tracheoesophageal fistula.

Am J Med Genet A 2019 11 22;179(11):2202-2206. Epub 2019 Aug 22.

Department of Pediatrics, Division of Genetics and Metabolism, University of Texas Southwestern Medical Center, Dallas, Texas.

Esophageal atresia (EA) with or without tracheoesophageal fistula (TEF) is a foregut defect that is a major component of the VATER/VACTERL association. The specific diagnostic criteria for the VATER/VACTERL association phenotype have changed over time. The current definition is presence of at least three of the following: Vertebral defects, Anal atresia, Cardiac defects, TE fistula, or Renal and Limb anomalies in the absence of a specific genetic diagnosis. Read More

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November 2019