221 results match your criteria Esophageal Atresia Tracheoesophageal Fistula


Novel candidate genes in esophageal atresia/tracheoesophageal fistula identified by exome sequencing.

Eur J Hum Genet 2020 Jul 8. Epub 2020 Jul 8.

Department of Pediatrics, Columbia University Medical Center, New York, NY, USA.

The various malformations of the aerodigestive tract collectively known as esophageal atresia/tracheoesophageal fistula (EA/TEF) constitute a rare group of birth defects of largely unknown etiology. Previous studies have identified a small number of rare genetic variants causing syndromes associated with EA/TEF. We performed a pilot exome sequencing study of 45 unrelated simplex trios (probands and parents) with EA/TEF. Read More

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http://dx.doi.org/10.1038/s41431-020-0680-2DOI Listing

Genetic Mouse Models and Induced Pluripotent Stem Cells for Studying Tracheal-Esophageal Separation and Esophageal Development.

Stem Cells Dev 2020 Jul 2. Epub 2020 Jul 2.

Esophageal Development and Engineering Laboratory, Sainte-Justine Research Centre, Montreal, Quebec, Canada.

Esophagus and trachea arise from a common origin, the anterior foregut tube. The compartmentalization process of the foregut into the esophagus and trachea is still poorly understood. Esophageal atresia/tracheoesophageal fistula (EA/TEF) is one of the most common gastrointestinal congenital defects with an incidence rate of 1 in 2,500 births. Read More

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http://dx.doi.org/10.1089/scd.2020.0075DOI Listing

Human exome and mouse embryonic expression data implicate ZFHX3, TRPS1, and CHD7 in human esophageal atresia.

PLoS One 2020 5;15(6):e0234246. Epub 2020 Jun 5.

Institute of Human Genetics, Medical Faculty of Bonn, University of Bonn, Bonn, Germany.

Introduction: Esophageal atresia with or without tracheoesophageal fistula (EA/TEF) occurs approximately 1 in 3.500 live births representing the most common malformation of the upper digestive tract. Only half a century ago, EA/TEF was fatal among affected newborns suggesting that the steady birth prevalence might in parts be due to mutational de novo events in genes involved in foregut development. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234246PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7274392PMC

Scoliosis after thoracotomy repair of esophageal atresia: a systematic review.

Pediatr Surg Int 2020 Jul 25;36(7):755-761. Epub 2020 May 25.

Department of Paediatric Surgery, Wellington Children's Hospital, Riddiford Street, Newtown, Wellington, 6021, New Zealand.

Standard surgical repair of esophageal atresia/tracheoesophageal fistula (EA/TEF) is via a right posterolateral thoracotomy. A recognized complication is the later development of scoliosis. The prevalence and pathogenesis of secondary scoliosis are poorly understood. Read More

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http://dx.doi.org/10.1007/s00383-020-04683-3DOI Listing

Efficacy of a standardized tube weaning program in pediatric patients with feeding difficulties after successful repair of their esophageal atresia/tracheoesophageal fistula.

Eur J Pediatr 2020 May 15. Epub 2020 May 15.

Department of Paediatrics and Adolescent Medicine, Division of General Pediatrics, Medical University of Graz, Auenbruggerplatz 34/2, 8010, Graz, Austria.

Children born with esophageal atresia (EA) might suffer from significant oral feeding problems which could evolve into tube dependency. The primary aim of the study was to define the outcome of tube weaning in children after successful EA repair and to compare outcomes in children with short gap/TEF (tracheoesophageal fistula) and long-gap EA. Data of 64 children (28 with short-gap EA/TEF with primary anastomosis and 36 with long-gap EA with delayed surgical repair) who participated in a standardized tube weaning program based on the "Graz model of tube weaning" (in/outpatients in an intensive 3-week program, online coaching (Netcoaching) only, or a combined 2-week intensive onsite followed by online treatment "Eating School") from 2009 to 2019 was evaluated. Read More

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http://dx.doi.org/10.1007/s00431-020-03673-wDOI Listing

The value of prophylactic chest tubes in tracheoesophageal fistula repair.

Pediatr Surg Int 2020 Jun 6;36(6):687-696. Epub 2020 May 6.

Division of Pediatric Surgery, The Saban Research Institute, Children's Hospital Los Angeles, 4650 Sunset Blvd., Mailstop #100, Los Angeles, CA, 90027, USA.

Purpose: Intraoperative chest tubes (IOCTs) can be placed during esophageal atresia/tracheoesophageal fistula (EA/TEF) repair to control pneumothoraces and detect esophageal leaks, potentially preventing the need for postoperative chest tubes (POCTs). However, data are lacking regarding IOCTs' effect. We hypothesized that IOCT placement would not reduce the risk of POCT placement and would increase hospital length of stay (LOS). Read More

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http://dx.doi.org/10.1007/s00383-020-04664-6DOI Listing

Patterns of malformation associated with esophageal atresia/tracheoesophageal fistula: A retrospective single center study.

Am J Med Genet A 2020 06 6;182(6):1351-1363. Epub 2020 Apr 6.

Department of Pediatrics, Division of Genetics and Dysmorphology, UC San Diego/Rady Children's Hospital, San Diego, California.

Esophageal atresia/tracheoesophageal fistula (EA/TEF) is one of the most common gastrointestinal birth defects. It can occur in isolation or in association with other birth defects or genetic syndromes. We retrospectively reviewed the EA/TEF cases evaluated at Rady Children's Hospital San Diego (San Diego, CA) between 2007 and 2016. Read More

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http://dx.doi.org/10.1002/ajmg.a.61582DOI Listing

Nationwide analysis of mortality and hospital readmissions in esophageal atresia.

J Pediatr Surg 2020 May 12;55(5):824-829. Epub 2020 Feb 12.

Dewitt-Daughtry Family Department of Surgery, Division of Pediatric Surgery, University of Miami Miller School of Medicine. Electronic address:

Purpose: The purpose of this study is to identify determinants of mortality and hospital readmission in infants born with esophageal atresia ± tracheoesophageal fistula.

Methods: The Nationwide Readmissions Database (2010-2014) was queried for newborns with a diagnosis of esophageal atresia. Outcomes included mortality and readmissions at 30-day and 1-year. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2020.01.025DOI Listing

Outcome of thoracoscopic repair of type-C esophageal atresia: a single-center experience from North Africa.

Dis Esophagus 2020 Feb 12. Epub 2020 Feb 12.

Pediatric Surgical Department, Cairo University Specialized Pediatric Hospital, Cairo, Egypt.

Thoracoscopic repair of esophageal atresia is gaining popularity worldwide attributable to availability and advances in minimally invasive instruments. In this report, we presented our experience with thoracoscopic esophageal atresia/tracheoesophageal fistula (EA/TEF) repair in our tertiary care institute. A prospective study on short-gap type-C EA/TEF was conducted at Cairo University Specialized Pediatric Hospital between April 2016 and 2018. Read More

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http://dx.doi.org/10.1093/dote/doaa001DOI Listing
February 2020

Gastrointestinal diseases among relatives of patients with esophageal atresia with or without tracheoesophageal fistula.

Transl Pediatr 2019 Dec;8(5):378-382

Department of Neonatology and Pediatric Intensive Care, Children's Hospital, University of Bonn, Bonn, Germany.

Background: Several studies have identified genetic factors that are associated with the formation of isolated and non-isolated esophageal atresia with or without tracheoesophageal fistula (EA/TEF) in human and mice. Some of these genetic factors like FOXF1/Foxf1 are associated with Barrett syndrome, esophageal carcinoma or tumors of the gastrointestinal tract. Here, we investigated the prevalence of common gastrointestinal diseases among EA/TEF patients and their first- and second-degree relatives (parents and grandparents). Read More

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http://dx.doi.org/10.21037/tp.2019.04.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970114PMC
December 2019

Development of an instrumented thoracoscopic surgical trainer for objective evaluation of esophageal atresia/tracheoesophageal fistula repair.

Med Biol Eng Comput 2020 Mar 11;58(3):601-609. Epub 2020 Jan 11.

Department of Paediatric Surgery, Christchurch Hospital, Christchurch, New Zealand.

Operative repair of complex conditions such as esophageal atresia and tracheoesophageal fistula (EA/TEF) is technically demanding, but few training opportunities exist outside the operating theater for surgeons to attain these skills. Learning them during surgery on actual neonates where the stakes are high, margins for error narrow, and where outcomes are influenced by technical expertise, is problematic. There is an increasing demand for high-fidelity simulation that can objectively measure performance. Read More

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http://dx.doi.org/10.1007/s11517-019-02107-6DOI Listing

Pediatric Esophageal Dilatations: A Cross-Specialty Experience.

J Laparoendosc Adv Surg Tech A 2020 Feb 3;30(2):206-209. Epub 2019 Dec 3.

Department of Paediatric Surgery, Evelina London Children's Hospital, London, United Kingdom.

Esophageal dilatations are commonly performed in pediatric patients who have undergone an esophageal atresia/tracheoesophageal fistula (EA/TEF) repair or following caustic injury. We sought to compare the practice of esophageal dilatation across different specialties. We analyzed all patients who had an esophageal dilatation at our center between April 2014 and December 2018. Read More

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http://dx.doi.org/10.1089/lap.2019.0592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044759PMC
February 2020

Likelihood of meeting defined VATER/VACTERL phenotype in infants with esophageal atresia with or without tracheoesophageal fistula.

Am J Med Genet A 2019 11 22;179(11):2202-2206. Epub 2019 Aug 22.

Department of Pediatrics, Division of Genetics and Metabolism, University of Texas Southwestern Medical Center, Dallas, Texas.

Esophageal atresia (EA) with or without tracheoesophageal fistula (TEF) is a foregut defect that is a major component of the VATER/VACTERL association. The specific diagnostic criteria for the VATER/VACTERL association phenotype have changed over time. The current definition is presence of at least three of the following: Vertebral defects, Anal atresia, Cardiac defects, TE fistula, or Renal and Limb anomalies in the absence of a specific genetic diagnosis. Read More

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http://dx.doi.org/10.1002/ajmg.a.61337DOI Listing
November 2019
2 Reads

Assessment of the Concerns of Caregivers of Children with Repaired Esophageal Atresia-Tracheoesophageal Fistula Related to Feeding-Swallowing Difficulties.

Dysphagia 2020 Jun 13;35(3):438-442. Epub 2019 Aug 13.

Department of Pediatric Surgery, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

The study aimed to assess concerns of caregivers of children with EA-TEF related to feeding-swallowing difficulties, compare the concerns according to type of atresia and repair time, and investigate its relationship with time to start oral feeding. Caregivers accompanying 64 children with EA-TEF were included. Age, sex, type of atresia, repair time, and time to start oral feeding were noted. Read More

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http://dx.doi.org/10.1007/s00455-019-10046-5DOI Listing
June 2020
4 Reads

Transition Zone in Total Colonic Aganglionosis and Colorectal Hirschsprung's Disease Shows a Similar Trend of Mucosal Innervation: Image Processing and Analysis Study.

Pediatr Dev Pathol 2020 Mar-Apr;23(2):127-131. Epub 2019 Aug 6.

Department of Pathology and Laboratory Medicine, Albany Medical Center, Albany, New York.

The aganglionic segment of bowel in Hirschsprung's disease (HD) varies in length. It is not clear whether total colonic aganglionosis (TCA) merely represents a long form of HD or a different phenotype of the disease. Animal model studies suggest that TCA may have a longer transition zone (TZ) than conventional colorectal HD. Read More

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http://dx.doi.org/10.1177/1093526619864225DOI Listing
August 2019
3 Reads

Neonatal surgery in low- vs. high-volume institutions: a KID inpatient database outcomes and cost study after repair of congenital diaphragmatic hernia, esophageal atresia, and gastroschisis.

Pediatr Surg Int 2019 Nov 1;35(11):1293-1300. Epub 2019 Aug 1.

Division of Pediatric Surgery, Children's Hospital Colorado, Aurora, CO, 80045, USA.

Background/purpose: The volume-outcome relationship and optimal surgical volumes for repair of congenital anomalies in neonates is unknown.

Methods: A retrospective study of infants who underwent diaphragmatic hernia (CDH), gastroschisis (GS), and esophageal atresia/tracheoesophageal fistula (EA/TEF) repair at US hospitals using the Kids' Inpatient Database 2009-2012. Distribution of institutional volumes was calculated. Read More

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http://dx.doi.org/10.1007/s00383-019-04525-xDOI Listing
November 2019
4 Reads

Thoracoscopy vs. thoracotomy for the repair of esophageal atresia and tracheoesophageal fistula: a systematic review and meta-analysis.

Pediatr Surg Int 2019 Nov 29;35(11):1167-1184. Epub 2019 Jul 29.

Department of Pediatric Surgery, Children's Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, ON, K1H 8L1, Canada.

Esophageal atresia (EA) and tracheoesophageal fistula (TEF) require emergency surgery in the neonatal period to prevent aspiration and respiratory compromise. Surgery was once exclusively performed via thoracotomy; however, there has been a push to correct this anomaly thoracoscopically. In this study, we compare intra- and post-operative outcomes of both techniques. Read More

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http://dx.doi.org/10.1007/s00383-019-04527-9DOI Listing
November 2019
3 Reads

Critical design and validation considerations for the development of neonatal minimally invasive surgery simulators.

J Pediatr Surg 2019 Nov 7;54(11):2448-2452. Epub 2019 Jun 7.

University of Otago, Christchurch, New Zealand; Department of Paediatric Surgery, Canterbury, District Health Board, New Zealand.

Background/purpose: Pediatric surgical trainees have limited exposure to advanced minimally invasive surgery (MIS) during their clinical training, particularly for cases such as esophageal atresia/tracheoesophageal fistula (EA/TEF). Simulation on validated neonatal models offers an alternative means of training that may augment traditional forms of training; but to be useful, they must fulfill certain criteria.

Methodology: Review of the currently available MIS, thoracoscopic and laparoscopic, simulators for pediatric surgery, and identification of those factors that contribute to their fidelity and validity as a training tool that must be incorporated in the design of future simulation models. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2019.05.022DOI Listing
November 2019
10 Reads

The functional chewing training for chewing dysfunction in children with repaired EA-TEF.

J Pediatr Surg 2020 Apr 7;55(4):635-638. Epub 2019 May 7.

Hacettepe University, Faculty of Medicine, Department of Pediatric Surgery, Ankara, Turkey. Electronic address:

Background/purpose: Chewing disorders (CD) may cause restrictions in solid food intake and can be seen in 37% of children with esophageal atresia-tracheoesophageal fistula (EA-TEF). The Functional Chewing Training (FCT) is a holistic approach to improve chewing function (CF) in children. The study aimed to evaluate the effects of FCT on CF in children with EA-TEF. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223468193033
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http://dx.doi.org/10.1016/j.jpedsurg.2019.04.028DOI Listing
April 2020
44 Reads

Outcomes of multi-gestational pregnancies affected by esophageal atresia - tracheoesophageal fistula.

J Pediatr Surg 2019 Oct 6;54(10):2080-2083. Epub 2019 May 6.

Division of General and Thoracic Surgery, The Hospital for Sick Children, Department of Surgery, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Background: Contemporary outcomes of infants with esophageal atresia with or without tracheoesophageal fistula (EA/TEF) from multi-gestational pregnancies compared to those of singleton pregnancies have not been reported.

Methods: A single-center retrospective review of EA/TEF patients born from 1999 to 2013 was performed. Patient demographics, gestational age (GA), birth weight, associated anomalies, requirement for gastrostomy tube and mortality were reviewed. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2019.04.026DOI Listing
October 2019
10 Reads

The Use of Endoclips in Thoracoscopic Correction of Esophageal Atresia: Advantages or Complications?

J Laparoendosc Adv Surg Tech A 2019 Jul 6;29(7):976-980. Epub 2019 May 6.

1 Department of Pediatric Surgery and Pediatric Minimally Invasive Surgery and New Technologies, San Bortolo Hospital, Vicenza, Italy.

Thoracoscopic correction of esophageal atresia (EA) with tracheoesophageal fistula (TEF) has been increasingly widespread, but is still one of the most advanced pediatric surgical skills. This procedure has a challenging learning curve, and usually initially requires a longer operative time than the open approach; furthermore to perform this intervention, the surgeon must be very experienced in endocorporeal knotting. In our opinion, standardization of the technique and the application of "tricks" (including the use of titanium endoclips for TEF closure) to make surgical steps easier, faster, and safe would be useful to the surgeon and to the patient above all. Read More

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http://dx.doi.org/10.1089/lap.2018.0388DOI Listing
July 2019
7 Reads

Innovative management of severe tracheobronchomalacia using anterior and posterior tracheobronchopexy.

Laryngoscope 2020 Feb 25;130(2):E65-E74. Epub 2019 Mar 25.

Department of Otolaryngology and Communication Enhancement, Boston Children's Hospital, Boston, Massachusetts, U.S.A.

Objectives/hypothesis: Combined anterior and posterior tracheobronchopexy is a novel surgical approach for the management of severe tracheobronchomalacia (TBM). We present our institutional experience with this procedure. Our objective was to determine the utility and safety of anterior and posterior tracheopexy in the treatment of severe TBM. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/lary.27938
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http://dx.doi.org/10.1002/lary.27938DOI Listing
February 2020
52 Reads

Postoperative noninvasive ventilation and complications in esophageal atresia-tracheoesophageal fistula.

J Pediatr Surg 2019 May 31;54(5):945-948. Epub 2019 Jan 31.

Pediatric Surgery, Centre Hospitalier Universitaire, Sainte-Justine, Canada; Esophageal Atresia Clinic, Department of Pediatric Gastroenterology, Centre Hospitalier Universitaire, Sainte Justine, Canada. Electronic address:

Purpose: This study examines the impact of postoperative noninvasive ventilation strategies on outcomes in esophageal atresia-tracheoesophageal fistula (EA-TEF) patients.

Methods: A single center retrospective chart review was conducted on all neonates followed at the EA-TEF Clinic from 2005 to 2017. Primary outcomes were: survival, anastomotic leak, stricture, pneumothorax, and mediastinitis. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2019.01.023DOI Listing
May 2019
11 Reads

Oesophageal atresia with tracheo-oesophageal fistula, ileal atresia and Hirschsprung's disease: outcome of a rare phenotype.

BMJ Case Rep 2019 Feb 22;12(2). Epub 2019 Feb 22.

Department of Paediatric Surgery, Centro Hospitalar e Universitário de Coimbra EPE, Coimbra, Portugal.

Oesophageal atresia with or without tracheo-oesophageal fistula, ileal atresia and Hirschsprung's disease are surgical malformations of the gastrointestinal tract typically diagnosed early in the neonatal period and varying in severity and prognosis. This report describes a full-term male newborn presenting simultaneous oesophageal atresia with distal tracheo-oesophageal fistula, ileal atresia and Hirschsprung's disease. In addition to the complex types of gastrointestinal malformations involved, the combination of ileal atresia and Hirschsprung's disease, as well as ganglion cells distal to intestinal atresia, resulted in a challenging diagnosis. Read More

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http://dx.doi.org/10.1136/bcr-2018-226675DOI Listing
February 2019
7 Reads

Developmental Status of Children Operated for Esophageal Atresia with or without Tracheoesophageal Fistula Along with Maternal Stress, Their Quality of life, and Coping Abilities at AIIMS, New Delhi.

Eur J Pediatr Surg 2019 Feb 31;29(1):125-131. Epub 2018 Dec 31.

Department of Pediatric Surgery, All India Institute of Medical Sciences, Delhi, India.

Introduction:  Esophageal atresia with or without tracheoesophageal fistula (EA with or without TEF) is one of the neonatal surgical emergencies requiring surgical intervention in the early neonatal period, influencing the developmental outcome in the operated children. This study was aimed to assess the developmental status of children operated for EA with or without TEF along with maternal stress, their quality of life (QOL), and coping abilities.

Materials And Methods:  A descriptive cross-sectional survey was conducted on 51 children aged up to 5 years after EA with or without TEF repair and their mothers' in a tertiary care facility. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1676825
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http://dx.doi.org/10.1055/s-0038-1676825DOI Listing
February 2019
13 Reads

Prevalence and Predictive Factors of Histopathological Complications in Children with Esophageal Atresia.

Eur J Pediatr Surg 2019 Dec 19;29(6):510-515. Epub 2018 Dec 19.

Division of Pediatric Gastroenterology, CHU Sainte-Justine, Montreal, Quebec, Canada.

Objectives:  Endoscopic follow-up after esophageal atresia (EA) tracheoesophageal fistula (TEF) repair is recommended to detect esophageal histopathological complications. We investigated the prevalence of histopathologically proven esophageal complications (peptic esophagitis, gastric metaplasia, and eosinophilic esophagitis) and assessed the predictors of these complications in children with EA-TEF.

Materials And Methods:  This is a prospective longitudinal cohort study performed between September 2005 and December 2014 comprising 77 children with EA-TEF followed-up until February 2017. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1676505
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http://dx.doi.org/10.1055/s-0038-1676505DOI Listing
December 2019
15 Reads

Severe haemophilia A in a neonate presenting as haemopneumothorax after tracheo-oesophageal fistula-oesophageal atresia repair.

BMJ Case Rep 2018 Nov 8;2018. Epub 2018 Nov 8.

Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.

A male infant with oesophageal atresia and distal tracheo-oesophageal fistula (TEF type C) underwent right thoracotomy and transpleural repair of TEF on day 4 of life. He did not have a family history of coagulation disorders. A preoperative finding of prolonged partial thromboplastin time (PTT)>200 s was overlooked, and he went to surgery. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22552
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http://dx.doi.org/10.1136/bcr-2018-225526DOI Listing
November 2018
36 Reads

Relationships between hospital and surgeon operative volumes and outcomes of esophageal atresia/tracheoesophageal fistula repair.

J Pediatr Surg 2019 Jan 5;54(1):44-49. Epub 2018 Oct 5.

Center for Surgical Outcomes Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA. Electronic address:

Purpose: Most pediatric surgeons perform <2 esophageal atresia and tracheoesophageal fistula (EA/TEF) repairs annually. We aimed to determine whether higher surgeon and hospital volumes are associated with better outcomes after EA/TEF repair.

Methods: Neonates with a diagnosis and repair of EA/TEF at their index hospital admission in the Pediatric Health Information System from 1/2000 to 9/2015 were included. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223468183065
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http://dx.doi.org/10.1016/j.jpedsurg.2018.10.037DOI Listing
January 2019
21 Reads

Prevalence and natural history of scoliosis and associated congenital vertebral anomalies in patients operated for esophageal atresia with or without tracheoesophageal fistula.

J Pediatr Surg 2019 Jul 9;54(7):1308-1311. Epub 2018 Sep 9.

University of Montreal, Montreal, Canada; CHU Sainte-Justine, Montreal, Canada; Hôpital du Sacré-Coeur, Montreal, Canada. Electronic address:

Background: Scoliosis has been reported after repair of esophageal atresia with or without tracheoesophageal fistula (EA-TEF). This study aims to investigate the prevalence and natural history of scoliosis and associated congenital vertebral anomalies in patients operated for EATEF.

Methods: A retrospective review of patients operated for EA-TEF with radiological examination for the presence of scoliosis or associated spine congenital anomalies was done on 106 patients (ages 5-19 years). Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2018.08.049DOI Listing
July 2019
13 Reads

Vocal cord dysfunction following esophageal atresia and tracheoesophageal fistula (EA/TEF) repair.

J Pediatr Surg 2019 Aug 9;54(8):1551-1556. Epub 2018 Sep 9.

Division of General and Thoracic Surgery, The Hospital for Sick Children, University of Toronto, ON, Canada. Electronic address:

Background: The purpose of this study was to determine risk factors and long-term outcomes in patients with esophageal atresia +/-tracheoesophageal fistula (EA/TEF) with vocal cord dysfunction (VCD) owing to recurrent laryngeal nerve (RLN) injury.

Method: A retrospective chart review was performed for EA/TEF patients repaired at our institution from 1999 to 2014 (REB #1000032265).

Results: Of 197 patients, 22 (11. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223468183054
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http://dx.doi.org/10.1016/j.jpedsurg.2018.08.041DOI Listing
August 2019
45 Reads

Hypertrophic pyloric stenosis following repair of oesophageal atresia and tracheo-oesophageal fistula in a neonate.

BMJ Case Rep 2018 Sep 21;2018. Epub 2018 Sep 21.

Department of Pediatric Surgery, School of Medicine, Harran University, Sanliurfa, Turkey.

Development of hypertrophic pyloric stenosis (HPS) after a few weeks of repair of an oesophageal atresia (OA) and tracheo-oesophageal fistula (TOF) is a rare condition in early infancy. Although vomiting or feeding intolerance in operated cases of OA+TOF are attributed to oesophageal stricture, gastro-oesophageal reflux and oesophageal dysmotility, it may also be caused by HPS. Herein, we report a newborn infant who had OA and TOF operation on day 2 of life and diagnosed to have HPS at 15th day of age. Read More

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420448/
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https://link.springer.com/content/pdf/10.1007%2FBF02664059.p
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http://europepmc.org/articles/PMC4420448
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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22629
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http://dx.doi.org/10.1136/bcr-2018-226292DOI Listing
September 2018
24 Reads

Infants with esophageal atresia and right aortic arch: Characteristics and outcomes from the Midwest Pediatric Surgery Consortium.

J Pediatr Surg 2019 Apr 21;54(4):688-692. Epub 2018 Aug 21.

Division of Pediatric Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI.

Purpose: Right sided aortic arch (RAA) is a rare anatomic finding in infants with esophageal atresia with or without tracheoesophageal fistula (EA/TEF). In the presence of RAA, significant controversy exists regarding optimal side for thoracotomy in repair of the EA/TEF. The purpose of this study was to characterize the incidence, demographics, surgical approach, and outcomes of patients with RAA and EA/TEF. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2018.08.002DOI Listing
April 2019
36 Reads

State of Play: Eight Decades of Surgery for Esophageal Atresia.

Eur J Pediatr Surg 2019 Feb 15;29(1):39-48. Epub 2018 Aug 15.

Department of Pediatric Surgery, Hannover Medical School, Hannover, Germany.

Aim:  Surgical expertise and advances in technical equipment and perioperative management have led to enormous progress in survival and morbidity of patients with esophageal atresia (EA) in the last decades. We aimed to analyze the available literature on surgical outcome of EA for the past 80 years.

Materials And Methods:  A PubMed literature search was conducted for the years 1944 to 2017 using the keywords "esophageal/oesophageal atresia," "outcome," "experience," "management," and "follow-up/follow up. Read More

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http://dx.doi.org/10.1055/s-0038-1668150DOI Listing
February 2019
14 Reads

Vocal cord paralysis appears to be an acquired lesion in children with repaired esophageal atresia/tracheoesophageal fistula.

Int J Pediatr Otorhinolaryngol 2018 Sep 19;112:45-47. Epub 2018 Jun 19.

Respiratory Unit, Academic Department of Pediatrics, Bambino Gesù Children's Hospital, Piazza di Sant'Onofrio, 4, 00165 Roma, RM, Italy. Electronic address:

Objectives: Determine whether vocal cord paresis or paralysis (VCP/P) following surgical repair of congenital esophageal atresia/tracheoesophageal fistula (EA/TEF) is generally a primary anomaly, or is secondary to EA/TEF repair.

Methods: We carried out a retrospective study based on a recently published protocol, which included the systematic performance of a laryngo-tracheo-bronchoscopy before and after EA/TEF repair.

Results: There were 105 patients with EA/TEF referred for multidisciplinary follow-up, between 2010 and 2015. Read More

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http://dx.doi.org/10.1016/j.ijporl.2018.06.031DOI Listing
September 2018
37 Reads
1.320 Impact Factor

Long-term Quality of Life in Neonatal Surgical Disease.

Ann Surg 2018 09;268(3):497-505

Children's Hospital of Wisconsin and Division of Pediatric Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI.

Objective: This prospective observational study was designed to assess Pediatric Quality of Life (PedsQL) after surgical treatment for congenital diaphragmatic hernia (CDH), esophageal atresia/tracheoesophageal fistula (EA/TEF), Hirschsprung disease (HD), gastroschisis (GAS), omphalocele (OMP), and necrotizing enterocolitis (NEC).

Summary Of Background Data: Improvements in neonatal and surgical care have led to increased survival for many newborn conditions. Quality of life in these patients is seldom explored in a longitudinal manner. Read More

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http://dx.doi.org/10.1097/SLA.0000000000002918DOI Listing
September 2018
37 Reads

Esophageal Atresia with Tracheoesophageal Fistula and Gastroesophageal Reflux in Children: Dental Considerations and Case Report.

J Clin Pediatr Dent 2018;42(4):256-261. Epub 2018 May 11.

Background: Esophageal Atresia (EA) is defined as the congenital interruption of the continuity of the esophagus. Pediatric patients also have other congenital conditions, such as Tracheo-Esophageal Fistula (TEF).

Case Report: A 7-year-old male with TEF referred by a Pediatric Cardiologist, with the principal complaint of "severe and generalized tooth wearing". Read More

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http://dx.doi.org/10.17796/1053-4628-42.4.3DOI Listing
November 2018
6 Reads

Successful Management of Chylothorax With Etilefrine: Case Report in 2 Pediatric Patients.

Pediatrics 2018 05;141(5)

Hospital de Emergencias Pediatricas, Lima, Perú; and

Chylothorax is defined as the accumulation of chyle within the pleural space. Originally described in 1917 by Pisek, it is the most common cause of pleural effusion in the neonatal period. The leading cause of chylothorax is laceration of the thoracic duct during surgery, which occurs in 0. Read More

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http://dx.doi.org/10.1542/peds.2016-3309DOI Listing
May 2018
14 Reads

Identification of rare heterozygous missense mutations in FANCA in esophageal atresia patients using next-generation sequencing.

Gene 2018 Jun 3;661:182-188. Epub 2018 Apr 3.

Department of Cardiothoracic Surgery, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu 210000, China. Electronic address:

Esophageal atresia and tracheoesophageal fistula (EA/TEF) are relatively common malformations in newborns, but the etiology of EA/TEF remains unknown. Fanconi anemia (FA) complementation group A (FANCA) is a key component of the FA core complex and is essential for the activation of the DNA repair pathway. The middle region (amino acids 674-1208) of FANCA is required for its interaction with FAAP20. Read More

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http://dx.doi.org/10.1016/j.gene.2018.03.097DOI Listing
June 2018
64 Reads

Infants Born with Esophageal Atresia with or without Tracheo-Esophageal Fistula: Short- and Long-Term Outcomes.

Isr Med Assoc J 2018 Mar;20(3):161-166

Department of Pediatric Surgery, Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel.

Background: The estimated incidence of esophageal atresia (EA) with or without tracheo-esophageal fistula (TEF) is 1:3500 live births. During childhood these patients have various co-morbidities, but the overall quality of life among adults is similar to that of the general population.

Objectives: To evaluate short- and long-term co-morbidities and quality of life among infants born with EA ± TEF at a large single medical center. Read More

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March 2018
11 Reads

Oral feeding outcomes in infants with esophageal atresia and tracheoesophageal fistula.

J Pediatr Surg 2018 May 7;53(5):929-932. Epub 2018 Feb 7.

Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Alberta, Edmonton, AB, Canada.

Purpose: The purpose of this study was to explore oral feeding outcomes in infants born with type-C esophageal atresia and tracheoesophageal fistula (EA/TEF).

Methods: A retrospective cohort study of all infants born between January 2005 and December 2015 undergoing surgery for type-C EA/TEF at the University of Alberta Hospital was performed.

Results: Fifty-seven infants were identified, of which 61. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2018.02.018DOI Listing
May 2018
12 Reads

Novel thoracoscopic navigation surgery for neonatal chylothorax using indocyanine-green fluorescent lymphography.

J Pediatr Surg 2018 Jun 1;53(6):1246-1249. Epub 2018 Feb 1.

Department of Pediatric Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa, Nagoya 466-8550, Japan.

Background: Postoperative chylothorax after surgery for esophageal atresia/tracheoesophageal fistula (TEF) is a rare but serious complication, especially in neonates. This study aimed to identify the thoracic duct and ligate chylous leakage sites, using thoracoscopic navigation of an indocyanine-green (ICG)-based near-infrared (NIR) fluorescence imaging system.

Methods: From November 2014 to April 2017, thoracoscopic intraoperative ICG-NIR imaging was performed in 10 newborns (11 surgeries) with first TEF operation or with persistent postoperative chylothorax after TEF operation. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2018.01.019DOI Listing
June 2018
16 Reads

Structural airway abnormalities contribute to dysphagia in children with esophageal atresia and tracheoesophageal fistula.

J Pediatr Surg 2018 Sep 31;53(9):1655-1659. Epub 2018 Jan 31.

Division of Pediatric Surgery, Department of Surgery, Emory University School of Medicine, Children's Healthcare of Atlanta, Atlanta, GA, United States.

Background: Long-term dysphagia occurs in up to 50% of repaired esophageal atresia and tracheoesophageal fistula (EA/TEF) patients. The underlying factors are unclear and may include stricture, esophageal dysmotility, or associated anomalies. Our purpose was to determine whether structural airway abnormalities (SAA) are associated with dysphagia in EA/TEF. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2017.12.025DOI Listing
September 2018
11 Reads

Neurodevelopmental outcomes of infants with esophageal atresia and tracheoesophageal fistula.

J Pediatr Surg 2018 Sep 31;53(9):1651-1654. Epub 2018 Jan 31.

Division of Neonatology, and Department of Pediatrics, The Hospital for Sick Children, and University of Toronto, Toronto, ON, Canada. Electronic address:

Background: Esophageal atresia with or without tracheoesophageal fistula (EA/TEF) is a complex disorder, and most outcome data are confined to mortality and feeding-related morbidities. Our objective was to examine mortality, growth and neurodevelopmental outcomes in a large recent cohort of infants with EA/TEF.

Methods: Single center study of EA/TEF infants referred from January 2000 to December 2015. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2017.12.024DOI Listing
September 2018
9 Reads

Pre- and post-operative visualization of neonatal esophageal atresia/tracheoesophageal fistula via magnetic resonance imaging.

J Pediatr Surg Case Rep 2018 Feb 3;29:5-8. Epub 2017 Oct 3.

Division of Neonatology and Pulmonary Biology, Cincinnati Children's Hospital, OH 45229 USA.

Esophageal atresia (EA) is a relatively uncommon congenital anomaly, often observed in conjunction with tracheoesophageal fistula (TEF). Surgical repair in neonates typically takes place with little information about the pre-existing EA/TEF structure because there are currently no acceptable tools for evaluating EA/TEF anatomy prior to repair; chest x-ray radiograph does not identify malformation sub-type or gap length, while x-ray computed tomography (CT) demonstrate an unacceptably high exposure to ionizing radiation. There is a need for safe imaging methods to evaluate pre-operative EA/TEF anatomy, which would add value in surgical planning; this need may be met with high-resolution structural MRI. Read More

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http://dx.doi.org/10.1016/j.epsc.2017.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794017PMC
February 2018
14 Reads

Characteristics and outcomes of children with ductal-dependent congenital heart disease and esophageal atresia/tracheoesophageal fistula: A multi-institutional analysis.

Surgery 2018 04 8;163(4):847-853. Epub 2018 Jan 8.

Section of Cardiology, Department of Pediatrics, Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA. Electronic address:

Background: Extracardiac birth defects are associated with worse outcomes in congenital heart disease (CHD). The impact of esophageal atresia/trachea-esophageal fistula (EA/TEF) on outcomes after surgery for ductal-dependent CHD is unknown.

Methods: Retrospective matched cohort study using the Pediatric Health Information System database from 07/2004 to 06/2015. Read More

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http://dx.doi.org/10.1016/j.surg.2017.09.010DOI Listing
April 2018
14 Reads

Clinical predictors and prevalence of receiving special preschool/school support in children with repaired esophageal atresia.

J Pediatr Surg 2018 Oct 28;53(10):1970-1975. Epub 2017 Nov 28.

Department of Pediatric Surgery, Queen Silvia Children's Hospital, Sahlgrenska University Hospital, 416 85 Gothenburg, Sweden; Institute of Clinical Sciences, Department of Pediatrics, Gothenburg University, The Queen Silvia Children's Hospital, 416 86 Gothenburg, Sweden. Electronic address:

Background/purpose: In a sparsely investigated field, we aimed to evaluate the use of special preschool/school support among children with repaired esophageal atresia (EA) and/or tracheoesophageal fistula (TEF), the predicting clinical factors for this support, and level of school absence.

Methods: Data on 119 EA/TEF children 2-17years old were collected through medical records and questionnaires (response rate 95%). Logistical regression analysis identified clinical predictors of special preschool/school support in the population without genetic disorders (n=105). Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2017.11.057DOI Listing
October 2018
2 Reads

Prevalence of Laryngeal Cleft in Pediatric Patients With Esophageal Atresia.

JAMA Otolaryngol Head Neck Surg 2018 02;144(2):164-168

Department of Otolaryngology and Communication Enhancement, Boston Children's Hospital, Boston, Massachusetts.

Importance: Esophageal atresia (EA), with or without tracheoesophageal fistula (TEF), and laryngeal cleft are rare congenital anomalies that often occur together. Previous reports have established a link between EA/TEF and laryngeal cleft, but there have been no large case series to further characterize this relationship.

Objectives: To assess the prevalence of laryngeal cleft among patients with EA/TEF, identify associations between types of laryngeal cleft and EA/TEF, and identify factors associated with the timing of diagnosis for both conditions. Read More

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http://dx.doi.org/10.1001/jamaoto.2017.2682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839289PMC
February 2018
16 Reads

Chewing Function in Children with Repaired Esophageal Atresia-Tracheoesophageal Fistula.

Eur J Pediatr Surg 2018 Dec 6;28(6):534-538. Epub 2017 Dec 6.

Department of Pediatric Surgery, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

Introduction:  Feeding problems are common in children with esophageal atresia and tracheoesophageal fistula (EA-TEF); however, chewing disorders, which may cause inability to intake solid food, have not been evaluated. Therefore, we aimed to evaluate the chewing function in children with repaired EA-TEF.

Materials And Methods:  Age, sex, the type of atresia, the type of repair, and the time to start oral feeding were recorded. Read More

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http://dx.doi.org/10.1055/s-0037-1608930DOI Listing
December 2018
13 Reads