132,758 results match your criteria Esophageal Atresia Tracheoesophageal Fistula


Wide-area transepithelial sampling with computer-assisted 3-dimensional analysis (WATS) markedly improves detection of esophageal dysplasia and Barrett's esophagus: analysis from a prospective multicenter community-based study.

Dis Esophagus 2018 Dec 12. Epub 2018 Dec 12.

Gastroenterology, New York University Langone Medical Center, New York, NY, USA.

The 4-quadrant forceps biopsy (FB) protocol for identifying Barrett's esophagus (BE) and esophageal dysplasia (ED) suffers from poor sensitivity due to significant sampling error. We investigated the benefit of wide-area transepithelial sampling with 3-dimensional computer-assisted analysis (WATS) used adjunctively to the combination of random and targeted FB in the detection of ED, and as a secondary outcome, BE. In this multicenter prospective trial, community endoscopists at 21 sites utilized WATS as an adjunct to both targeted and random FB in patients undergoing BE screening and surveillance. Read More

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December 2018

Accuracy and Pitfalls in the Assessment of Early Gastrointestinal Lesions.

Dig Dis 2018 Dec 12:1-10. Epub 2018 Dec 12.

Clinic for Gastroenterology and Hepatology, Clinical Center of Serbia, Belgrade, Serbia.

Superficial neoplastic lesions of the digestive tract are usually asymptomatic, and often represent incidental findings on endoscopy. The Paris Classification was developed for the systematic evaluation of superficial lesions of the oesophagus, stomach and colon. The significance of this classification in clinical practice is that it allows the depth of invasion to be estimated. Read More

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December 2018

[Neoendocrine carcinoma of the esophagus: report of a case].

Rev Gastroenterol Peru 2018 Jul-Sep;38(3):293-296

Escuela de Medicina, Universidad Peruana de Ciencias Aplicadas. Lima, Perú; Departamento de Medicina Interna, Hospital Nacional Hipólito Unanue. Lima, Perú.

Neuroendocrine carcinoma of esophagus represents less than 2% of cases of cancer of the esophagus. This presentation is extremely unusual, as this type of carcinoma typically presents with greater frequency in bronchopulmonary regions. The symptoms are usually associated with esophageal obstruction and include odynophagia, dysphagia and weight loss and are not usually associated with Carcinoid syndrome. Read More

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December 2018

Pediatric Eosinophilic Esophagitis: Results of the European Retrospective Pediatric Eosinophilic Esophagitis Registry (RetroPEER).

J Pediatr Gastroenterol Nutr 2018 Dec 11. Epub 2018 Dec 11.

Institute of Gastroenterology, Nutrition, and Liver Disease, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.

Objectives: Recommendations for diagnosing and treating eosinophilic esophagitis (EoE) are evolving; however, information on real world clinical practice is lacking. To assess the practices of pediatric gastroenterologists diagnosing and treating EoE and to identify the triggering allergens in European children.

Methods: Retrospective anonymized data were collected from 26 European pediatric gastroenterology centers in 13 countries. Read More

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December 2018

Esophageal IgG4: Clinical, Endoscopic, and Histologic Correlations in Eosinophilic Esophagitis.

J Pediatr Gastroenterol Nutr 2018 Dec 11. Epub 2018 Dec 11.

Division of Pediatric Gastroenterology, Hepatology and Nutrition.

Objective: Recent studies show increased serum and esophageal IgG4 in patients with eosinophilic esophagitis (EoE), suggesting a possible IgG4-involved process. The role of IgG4 in pediatric EoE has not been extensively investigated. Our aim was to analyze IgG4 in esophageal tissue in children in parallel to that in adults with EoE. Read More

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December 2018
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PATHOLOGIC COMPLETE RESPONSE (YPT0 YPN0) AFTER CHEMOTHERAPY AND RADIOTHERAPY NEOADJUVANT FOLLOWED BY ESOPHAGECTOMY IN THE SQUAMOUS CELL CARCINOMA OF THE ESOPHAGUS.

Arq Bras Cir Dig 2018 Dec 6;31(4):e1405. Epub 2018 Dec 6.

Digestive Diseases Surgical Unit and Gastrocenter, Department of Surgery, School of Medical Sciences, State University of Campinas - UNICAMP , Campinas, SP, Brazil.

Background: Esophageal squamous cell carcinoma is an aggressive neoplasia that requires a multidisciplinary treatment in which survival and prognosis are still not satisfactory. The complete pathologic response to neoadjuvant chemotherapy and radiotherapy is considered a good prognosis factor, and esophagectomy is indicated.

Aim: Survival analysis of cases with pathologic complete response (ypT0 ypN0) to neoadjuvant chemotherapy and/or radiotherapy, submmitted to esophagectomy. Read More

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December 2018

Meta-analysis on the association between xeroderma pigmentosum Group A A23G polymorphism and esophageal cancer in a Chinese population.

J Cancer Res Ther 2018 Dec;14(Supplement):S1173-S1177

Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan 250012, China.

Aim Of The Study: Several studies have evaluated the correlation between xeroderma pigmentosum Group A (XPA) A23G polymorphism (rs 1800975) and esophageal cancer in Chinese people. However, the results are inconsistent. To assess the effects of XPA A23G variants on the risk for development of esophageal cancer in the Chinese population, a meta-analysis was performed. Read More

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December 2018

Tracking significant modules and key genes for esophageal squamous cell carcinoma based on differential modules.

J Cancer Res Ther 2018 Dec;14(Supplement):S1135-S1140

Department of General Surgery, Peking University International Hospital, Beijing 100026, China.

Background: The exact molecular mechanism of esophageal squamous cell carcinoma (ESCC) is still unknown, and the prognosis of ESCC has not been significantly improved.

Objective: To understand the molecular mechanism of ESCC, differential modules (DMs) and key genes were identified through conducting analysis on the differential co-expression network (DCN) based on the gene expression profiles of ESCC and protein-protein interaction (PPI) data.

Materials And Methods: First, gene expression profiles of ESCC and PPI data recruiting and preprocessing were conducted; then, a DCN was constructed based on the gene co-expression and gene differential expression in ESCC; in the following, candidate DMs were mined from DCN through a systemic module searching strategy, and significance analysis was performed on candidate DMs to identify DMs; moreover, significant genes contained in the DMs were analyzed to identify the underlying biomarkers for ESCC. Read More

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December 2018

Yes-Associated Protein 1 as a Novel Prognostic Biomarker for Gastrointestinal Cancer: A Meta-Analysis.

Biomed Res Int 2018 14;2018:4039173. Epub 2018 Nov 14.

Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.

Background: Yes-associated protein 1 (YAP1) is an effector of Hippo pathway, which plays a significant role in cell proliferation and tumor progression. The relationship between YAP1 and gastrointestinal cancer has been explored in many previous studies. We conducted a meta-analysis to explore the prognostic effect of YAP1 in patients with gastrointestinal cancer. Read More

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November 2018

The clinical use of pretreatment NLR, PLR, and LMR in patients with esophageal squamous cell carcinoma: evidence from a meta-analysis.

Cancer Manag Res 2018 22;10:6167-6179. Epub 2018 Nov 22.

Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi Zhuang Autonomous Region 541199, China,

Background And Purpose: The relationship between neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and lymphocyte to monocyte ratio (LMR) and the prognostic and clinicopathological significance in patients with esophageal squamous cell carcinoma (ESCC) has been reported by many studies. However, inconsistent results have been presented. The current study aimed to investigate the prognostic and clinicopathological role of NLR, PLR, and LMR in patients with ESCC by meta-analysis. Read More

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November 2018

Recurrence and prognostic model for identifying patients at risk for esophageal cancer after surgery.

Cancer Manag Res 2018 21;10:6109-6120. Epub 2018 Nov 21.

Department of Thoracic Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510060, China,

Objective: The aim of this study was to construct a risk model to assess overall survival (OS) and disease-free survival (DFS) in patients with esophageal cancer (EC) after surgery.

Patients And Methods: A total of 872 consecutive EC patients who had undergone surgery between February 2009 and October 2012 were retrospectively analyzed. The cutoff for risk value (RV) was inferred by receiver operating characteristic curves and the Youden index. Read More

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November 2018

Cytoskeleton-associated protein 4 is a novel serodiagnostic marker for esophageal squamous-cell carcinoma.

Onco Targets Ther 2018 20;11:8221-8226. Epub 2018 Nov 20.

Department of Oncology, Suqian People's Hospital, Nanjing Drum Tower Hospital Group, Suqian, China,

Background: Recent years have witnessed significant progress in the treatment of esophageal squamous-cell carcinoma (ESCC); however, the prognosis of ESCC is still unsatisfactory. Bio-markers are required to improve identification of high-risk populations and help management of ESCC. This study was to evaluate the role of serum CKAP4 in ESCC. Read More

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November 2018

Esophageal Metallic-Stent Migration: a Rare Cause of Anal Pain in a Patient with Gastric Cancer.

Indian J Surg Oncol 2018 Dec 16;9(4):576-577. Epub 2018 May 16.

2Department of Surgery, Hospital General Tacuba, ISSSTE, Mexico City, Mexico.

Stents are a great development for esophageal fistula treatment; however, stent migration is a frequent complication. A stent migration that caused anal pain is presented. A 79-year-old man with poorly differentiated gastric carcinoma was submitted to a total gastrectomy with a Roux-en-Y esophagojejunostomy. Read More

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December 2018

Impact of Spontaneous Breathing Trial on Work of Breathing Indices Derived From Esophageal Pressure, Electrical Activity of the Diaphragm, and Oxygen Consumption in Children.

Respir Care 2018 Dec 11. Epub 2018 Dec 11.

Pediatric Intensive Care Unit, Centre Hospitalier Universitaire (CHU) Sainte-Justine, Montreal, Québec, Canada.

Background: The present study aimed to characterize the behavior of 3 components of respiratory muscle function during mechanical ventilation weaning in children to better understand the respective impact of a spontaneous breathing trial on ventilatory mechanical action (esophageal pressure [P], ventilatory demand (electrical activity of the diaphragm [EA]), and oxygen consumption.

Methods: This was a prospective single-center study. All children ≥ 1 months and <18 y old who were intubated and on mechanical ventilation, and who were hospitalized in the pediatric ICU were eligible. Read More

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December 2018
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A heterogeneous label propagation approach to explore the potential associations between miRNA and disease.

J Transl Med 2018 Dec 11;16(1):348. Epub 2018 Dec 11.

Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Science, Ürümqi, 830011, China.

Background: Research on microRNAs (miRNAs) has attracted increasingly worldwide attention over recent years as growing experimental results have made clear that miRNA correlates with masses of critical biological processes and the occurrence, development, and diagnosis of human complex diseases. Nonetheless, the known miRNA-disease associations are still insufficient considering plenty of human miRNAs discovered now. Therefore, there is an urgent need for effective computational model predicting novel miRNA-disease association prediction to save time and money for follow-up biological experiments. Read More

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December 2018

A case of aortic thrombosis and embolism preceding the progression of early esophageal cancer.

J Cardiol Cases 2013 May 12;7(5):e123-e125. Epub 2013 Feb 12.

Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507, Japan.

Aortic thrombosis is rare, especially in non-atherosclerotic aortae. A 51-year-old woman presented with intermittent claudication in the right lower extremity. She was diagnosed as having peripheral artery disease on ultrasound. Read More

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Three-gene immunohistochemical panel predicts progression and unfavorable prognosis in esophageal squamous cell carcinoma.

Hum Pathol 2018 Dec 8. Epub 2018 Dec 8.

Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine, Shihezi 832002, China. Electronic address:

Esophageal squamous cell carcinoma (ESCC) is a highly invasive disease with a poor long-term survival rate. Although there has been progress in understanding the pathogenesis of ESCC, there are currently no molecular biomarkers that are used in routine clinical practices to determine prognosis. Therefore, the aim of this study was to determine a small immunohistochemical (IHC) panel that could predict the prognosis of patients with ESCC. Read More

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December 2018
2.769 Impact Factor

Long noncoding RNA CASC9 promotes LIN7A expression via miR-758-3p to facilitate the malignancy of ovarian cancer.

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Head and Neck and Genito-Urinary Oncology, Harbin Medical University Cancer Hospital, Harbin, China.

The long noncoding RNA cancer susceptibility 9 (CASC9) has been reported to be a pivot modulator in growth and metastasis of breast cancer, liver cancer, esophageal squamous cell carcinoma, lung adenocarcinoma, gastric cancer, and nasopharyngeal cancer. However, its potential roles in ovarian cancer remain unclear. In this study, we aimed at its functions and molecular mechanism in ovarian cancer progression. Read More

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December 2018

miR-133a-3p suppresses cell proliferation, migration, and invasion and promotes apoptosis in esophageal squamous cell carcinoma.

J Cell Physiol 2018 Dec 10. Epub 2018 Dec 10.

Department of Oncology, Linyi People's Hospital, Linyi, Shandong, China.

Objective: This study aimed to investigate the expression levels of miR-133a-3p and collagen type I α 1 (COL1A1) in esophageal squamous cell carcinoma (ESCC) to find out the relationship between miR-133a-3p and COL1A1 and their influence on ESCC propagation, migration, invasion, and apoptosis.

Methods: The messenger RNA expression levels of miR-133a-3p and COL1A1 in ESCC were detected by quantitative reverse-transcription polymerase chain reaction. The expression of COL1A1 protein was examined via western blot analysis and immunohistochemistry assay. Read More

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December 2018

Pneumatic dilation improves esophageal emptying and symptoms in patients with idiopathic esophago-gastric junction outflow obstruction.

Neurogastroenterol Motil 2018 Dec 10:e13522. Epub 2018 Dec 10.

Department of Internal Medicine, Division of Digestive Diseases and Nutrition, Joy McCann Culverhouse Center for Swallowing Disorders, University of South Florida, Tampa, Florida.

Background And Aims: Idiopathic Esophago-gastric outflow obstruction (EGJOO) is a new clinical entity resulting in delayed esophageal emptying secondary to a poorly relaxing lower esophageal sphincter. Little is known about treatment outcomes of idiopathic EGJOO patients. The aim of this study was to investigate the clinical response of pneumatic dilation (PD) in idiopathic EGJOO patients with a standing barium column and/or with pill arrest on timed barium esophagram (TBE) before and after undergoing PD. Read More

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December 2018

Role and mechanism of Dvl3 in the esophageal squamous cell carcinoma.

Eur Rev Med Pharmacol Sci 2018 Nov;22(22):7716-7725

Department of Gastroenterology, First Affiliated Hospital of Henan University of TCM, Henan, China.

Objective: The purpose of this project was to investigate the expression of Dishevelled-3 (Dvl3) in esophageal squamous cell carcinoma and cultured cells, and to determine the consequence of Dvl3 silencing in the tumorous properties of esophageal squamous cell carcinoma cells.

Patients And Methods: The expression of Dvl3 mRNA and protein in 50 cases of esophageal squamous cell carcinoma was detected. The expression of Dvl3 mRNA and protein was significantly elevated in esophageal squamous cell carcinoma tissues compared with atypical hyperplasia and normal esophageal mucosa. Read More

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November 2018

Pulmonary hypertension in Spanish patients with systemic sclerosis. Data from the RESCLE registry.

Clin Rheumatol 2018 Dec 7. Epub 2018 Dec 7.

Autoimmune Diseases Unit, Department of Internal Medicine, Hospital Universitario Vall d'Hebron, Barcelona, Spain.

Introduction: Our objective was to evaluate the pulmonary hypertension (PH) data for Spanish patients with systemic sclerosis (SSc), define the PH types and determine the associated factors.

Method: Descriptive study of PH-related data from the multicentre RESCLE registry. Estimated systolic pulmonary artery pressure (esPAP), measured via echocardiogram was considered elevated if ≥ 35 mmHg. Read More

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December 2018

Central compartment revision surgery for persistent or recurrent thyroid carcinoma: analysis of survival and complication rate.

Eur Arch Otorhinolaryngol 2018 Dec 10. Epub 2018 Dec 10.

Otorhinolaryngology-Head and Neck Surgery Department, University Hospital of Modena, Largo del Pozzo, 71, 41125, Modena, Italy.

Purpose: Locoregional recurrence of thyroid carcinoma is relatively common and reported rate are between 5 and 20%. Cervical nodes are usually involved, especially at the central compartment. The management of recurrent thyroid carcinoma at central compartment still remains challenging because of higher incidence of complication rate. Read More

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December 2018

Establishment of a novel and effective reflux laryngitis model in rabbits: a preliminary study.

Eur Arch Otorhinolaryngol 2018 Dec 10. Epub 2018 Dec 10.

The Department of Otolaryngology-Head and Neck Surgery, Eye, Ear, Nose, and Throat Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200030, China.

Purpose: To establish a novel and effective reflux model with a modified nasogastric aspiration tube and to investigate the association between different types of nasogastric aspiration tubes and reflux laryngitis, we conducted this study.

Methods: Thirty-eight healthy New Zealand albino rabbits (2.5-3. Read More

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December 2018

[Necrotizing esophagitis by stress-cardiomyopathy with right ventricular insufficiency].

Med Klin Intensivmed Notfmed 2018 Dec 10. Epub 2018 Dec 10.

Klinik für Gastroenterologie, Endokrinologie, Diabetologie und Allgemeine Innere Medizin, Klinikum Kassel, Kassel, Deutschland.

Acute necrotizing esophagitis ("black esophagus") is defined as complete necrosis of the esophageal mucosa, which typically affects the entire circumference. We report a case of a healthy 62-year-old woman, who became hemodynamically unstable due to stress cardiomyopathy with acute right heart failure. Transfusion-dependent anemia occurred 24 h later and an upper gastrointestinal endoscopy revealed a black discoloured mucosa of the distal esophagus. Read More

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December 2018

Esophageal transit scintigraphy in children: a user's guide and pictorial review.

Pediatr Radiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Radiology, Harvard Medical School, Boston Children's Hospital, 300 Longwood Ave., Boston, MA, 02115, USA.

Technical and clinical aspects of esophageal transit scintigraphy in pediatric patients are reviewed via several illustrative cases that highlight its utility in evaluating primary and secondary esophageal motility disorders. Read More

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December 2018

Ineffective Esophageal Motility Is Associated with Impaired Bolus Clearance but Does Not Correlate with Severity of Dysphagia.

Dig Dis Sci 2018 Dec 10. Epub 2018 Dec 10.

Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, 161 Fort Washington Avenue, Suite 862, New York, NY, 10032, USA.

Background: Ineffective esophageal motility (IEM) is defined as a distal contractile integral < 450 mmHg/s/cm in at least 50% of ten liquid swallows on high-resolution esophageal manometry (HREM). Whether this latest definition correlates with degree of symptoms has not been studied.

Methods: Patients presenting for HREM prospectively rated their symptoms using the Eckardt score. Read More

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December 2018

Methylation‑associated silencing of miR‑128 promotes the development of esophageal cancer by targeting COX‑2 in areas with a high incidence of esophageal cancer.

Int J Oncol 2018 Dec 4. Epub 2018 Dec 4.

Cancer Institute, Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China.

Esophageal cancer is one of the most common cancer types in the world, with a widely varying incidence between different regions. Zinc deficiency (ZD) is very common in high‑risk areas for esophageal cancer. Dietary ZD is reported to be associated with esophageal squamous cell carcinoma (ESCC). Read More

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December 2018

Molecular pathogenesis of esophageal squamous cell carcinoma: Identification of the antitumor effects of miR‑145‑3p on gene regulation.

Int J Oncol 2018 Dec 6. Epub 2018 Dec 6.

Department of Digestive Surgery, Breast and Thyroid Surgery, Graduate School of Medical Sciences, Kagoshima University, Kagoshima 890‑8520, Japan.

Although miR‑145‑5p (the guide strand of the miR‑145 duplex) is established as a tumor suppressive microRNA (miRNA or miR), the functional significance of miR‑145‑3p (the passenger strand of the miR‑145 duplex) in cancer cells and its targets remains obscure. In our continuing analysis of esophageal squamous cell carcinoma (ESCC) pathogenesis, the aim of the present study was to identify important oncogenes and proteins that are controlled by miR‑145‑3p. Overexpression of miR‑145‑3p significantly reduced cancer cell proliferation, migration and invasive abilities, and further increased apoptotic abilities. Read More

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December 2018

Association of preoperative inflammation-based prognostic score with survival in patients undergoing salvage esophagectomy.

Dis Esophagus 2018 Jul 26. Epub 2018 Jul 26.

Department of Gastrointestinal Surgery, Graduate School of Medicine, the University of Tokyo.

Salvage esophagectomy (SALV) is potentially beneficial for patients with residual or relapsed esophageal carcinoma after definitive chemoradiotherapy (dCRT), although preoperatively identifying good candidates for SALV remains difficult. We investigated the prognostic impacts of inflammatory and nutritional status in patients undergoing SALV after dCRT. Forty-seven SALV patients were retrospectively reviewed, of whom 46 (98%) had squamous cell carcinoma and 1 (2%) adenocarcinoma. Read More

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LONG-NONCODING RNAs in gastroesophageal cancers.

Noncoding RNA Res 2018 Dec 1;3(4):195-212. Epub 2018 Nov 1.

Department of Medicine (DIMED), Surgical Pathology & Cytopathology Unit, University of Padua, Padua, PD, Italy.

Despite continuing improvements in multimodal therapies, gastro-esophageal malignances remain widely prevalent in the population and is characterized by poor overall and disease-free survival rates. Due to the lack of understanding about the pathogenesis and absence of reliable markers, gastro-esophageal cancers are associated with delayed diagnosis. The increasing understanding about cancer's molecular landscape in the recent years, offers the possibility of identifying 'targetable' molecular events and in particular facilitates novel treatment strategies and development of biomarkers for early stage diagnosis. Read More

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December 2018

The Utility of Endoscopic Ultrasound-Guided Brachytherapy in Liver Metastasis: A Case Report and Review of the Literature.

Am J Med Case Rep 2018 14;6(9):189-192. Epub 2018 Oct 14.

Division of Gastroenterology, Department of Medicine, State University of New York-Downstate Medical Center, Brooklyn, NY 11203.

Endoscopic ultrasound guided brachytherapy (EGBT) has been reported to be useful in certain malignancies including esophageal and pancreatic cancers. Percutaneous or surgical placement of radioactive seeds into the liver secondaries (brachytherapy) has been done successfully, however, the utility of EGBT in liver metastasis remains largely unclear. In this case report, we demonstrate the safety, efficacy and feasibility of EUS guided brachytherapy (EGBT) in liver metastasis secondary to leiomyosarcoma. Read More

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October 2018

E2F transcription factor 8 promotes cell proliferation via CCND1/p21 in esophageal squamous cell carcinoma.

Onco Targets Ther 2018 15;11:8165-8173. Epub 2018 Nov 15.

Department of Cardiothoracic Surgery, Yancheng Third People's Hospital, The Affiliated Yancheng Hospital of Southeast University, Yancheng, Jiangsu 224001, PR China,

Purpose: E2F transcription factor 8 () is a novel member of the E2F family, but its function in esophageal squamous cell carcinoma (ESCC) remains unclear. This study aimed to research the function of in ESCC.

Materials And Methods: We used quantitative real-time PCR and Western blot analyses to detect the expression pattern of E2F8 in ESCC. Read More

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November 2018

Postmortem detection and histopathological features of canine spirocercosis-induced putative esophageal chondrosarcoma.

Vet World 2018 Nov 3;11(10):1376-1379. Epub 2018 Oct 3.

Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine and Animal Science, University of Peradeniya, Sri Lanka.

Aim: The objective of this study was to describe and characterize the postmortem and histopathological findings of putative esophageal chondrosarcoma associated with .

Materials And Methods: Spirocerca-associated esophageal nodules were collected from 54 dogs at postmortem examination and were stained with hematoxylin and eosin. Of the cases examined, 15 were selected randomly for further investigation, of which 11 were classified as non-neoplastic nodules while 4 had changes reflecting a neoplastic process. Read More

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November 2018

The diacylglycerol kinase α (DGKα)/Akt/NF-κB feedforward loop promotes esophageal squamous cell carcinoma (ESCC) progression via FAK-dependent and FAK-independent manner.

Oncogene 2018 Dec 7. Epub 2018 Dec 7.

Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Laboratory of Molecular Oncology, Peking University Cancer Hospital & Institute, 100142, Beijing, China.

Many reports have described DGKα as an oncogene, hence, we investigated its function and the underlying mechanisms in esophageal squamous cell carcinoma (ESCC) progression. This study demonstrated that DGKα was upregulated by inflammatory stimulants and formed feedforward loop with Akt/NF-κB signaling in ESCC cells. Mechanistically, DGKα-activated Akt/NF-κB signaling via stimulating PA production to reduce cAMP level and PTEN activity, and specifically, independently of its kinase function, through direct interaction with the FERM domain of FAK to relieve the auto-inhibitory effect of FERM domain on FAK. Read More

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December 2018

Persistent intestinal metaplasia after endoscopic eradication therapy of neoplastic Barrett's esophagus increases the risk of dysplasia recurrence: meta-analysis.

Gastrointest Endosc 2018 Dec 7. Epub 2018 Dec 7.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester. Electronic address:

Background And Aims: Endoscopic eradication therapy (EET) is the main treatment for dysplastic Barrett's esophagus and intramucosal adenocarcinoma. Although the goal of EET is to achieve complete remission of intestinal metaplasia (CRIM), treatment might achieve complete remission of dysplasia (CR-D) only, without achieving CRIM. Persistent intestinal metaplasia after eradication of dysplasia might carry a higher risk for progression into advanced neoplasia. Read More

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December 2018

Intratumoral heterogeneity of esophageal squamous cell carcinoma and its clinical significance.

Pathol Res Pract 2018 Nov 24. Epub 2018 Nov 24.

Department of Pathology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, China. Electronic address:

Recent studies have shown that intratumoral heterogeneity is prevalent in esophageal squamous cell cancer (ESCC) based on DNA sequencing and chromosome analysis in multiple regions from the same tumor. This study aimed to investigate the expression of ZNF750, EP300, MTOR and KMT2D and their intratumoral heterogeneity (ITH) in patients with ESCC. A total of 106 cases, who underwent esophagectomy from 2008 to 2010, with two foci from each case, were tested by immunohistochemistry(IHC) as well as 12 cases were tested by RNAscope in this study. Read More

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November 2018

Relation of Venous Thromboembolism Risk to Ischemic Stroke Risk in Hospitalized Patients with Cancer.

Am J Cardiol 2018 Nov 24. Epub 2018 Nov 24.

Division of Cardiovascular Medicine, White River Junction VA Medical Center, White River Junction, Vermont; Department of Medicine, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire. Electronic address:

Patients with cancer are at increased risk for venous thromboembolism (VTE). However, the relationship of cancer type to the risk of arterial thrombosis in patients with high VTE risk has not been described. The goal of this study is to determine the rate of arterial thrombosis in patients with different types of solid tumors stratified by VTE risk. Read More

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November 2018

Analysis of eosinophilic esophagitis in children with repaired congenital esophageal atresia.

J Allergy Clin Immunol 2018 Oct 21. Epub 2018 Oct 21.

Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio. Electronic address:

Background: A high prevalence of eosinophilic esophagitis (EoE) has been preliminarily reported in patients after repair of esophageal atresia (EA), but the basis of this association is unknown.

Objectives: We aimed to (1) characterize the EoE transcriptome in patients with EA, (2) compare the EoE transcriptome in patients with EoE and EA with that in patients with EoE alone, and (3) identify transcripts that could predispose patients with EA to EoE.

Methods: This single-center, population-based, retrospective study identified 4 EoE study cohorts: healthy control subjects, patients with EA and EoE (EA+EoE+), patients with EA without EoE (EA+EoE-), and patients with EoE without EA (EA-EoE+). Read More

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October 2018

Suture fistula revisited for long gap esophageal atresia.

J Pediatr Surg 2018 Nov 11. Epub 2018 Nov 11.

Division of Pediatric Surgery, Department of Surgery, Boonshoft School of Medicine, Dayton Children's Hospital, Dayton, OH. Electronic address:

Background: Long gap esophageal atresia presents a challenge to pediatric surgeons due to the variability in surgical management when primary anastomosis is not feasible. Mechanical traction procedures enhance tissue growth that allows early anastomosis, before delayed primary closure (DPC) would be attempted to allow for rapid oral feeding, or when operative discoveries require flexibility of the surgical plan. The Suture Fistula procedure, first published by Alan Shafer and Tirone David in 1974, is a simple, effective, but underutilized single-stage procedure which results in spontaneous fistulization of approximated, non-anastomosed esophageal segments using tension sutures. Read More

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November 2018

Esophageal blind sac fistula.

Cir Esp 2018 Dec 7. Epub 2018 Dec 7.

Departamento de Cirugía Oncológica, Instituto Nacional de Enfermedades Neoplásicas, Lima, Perú; Escuela de Postgrado, Universidad Privada San Martín de Porres, Lima, Perú.

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December 2018

Autologous Activated Fibrin Sealant for the Esophageal Anastomosis: A Feasibility Study.

J Surg Res 2019 Feb 27;234:49-53. Epub 2018 Sep 27.

Department of Gastrointestinal Surgery, VU University Medical Center, Amsterdam, the Netherlands.

Background: Esophageal cancer is surgically treated by means of an esophagectomy. However, esophagectomies are associated with high morbidity rates with dehiscence of the anastomosis occurring in 19% of these procedures in the Netherlands. Application of a fibrin sealant may improve mechanical strength of the anastomosis. Read More

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February 2019

Quantitative Assessment of the Blood Perfusion of the Gastric Conduit by Indocyanine Green Imaging.

J Surg Res 2019 Feb 23;234:303-310. Epub 2018 Oct 23.

Division of Gastroenterological Surgery, Chiba Cancer Center, 260-8717 Chiba, Japan.

Background: Indocyanine green (ICG) fluorescence imaging has been used to assess the blood perfusion of the gastrointestinal tract in surgery. Especially, it was used to determine the best anastomotic site. However, in previous studies, ICG fluorescence was judged subjectively based on the visual appearance. Read More

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February 2019

Phospho-Sphingosine Kinase 1 Expression in Lymphatic Spread of Esophageal Squamous Cell Carcinoma.

J Surg Res 2019 Feb 9;234:123-131. Epub 2018 Oct 9.

Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Chuo-ku, Niigata, Japan.

Background: Lymphatic spread is the main mode of progression of esophageal squamous cell carcinoma (ESCC). Sphingosine-1-phosphate (S1P) is a pleiotropic bioactive lipid mediator, which produced by sphingosine kinase 1 (SphK1) activated by phosphorylation. The SphK1-S1P axis has a crucial role in lymphangiogenesis. Read More

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February 2019

Pharmacotherapy for metastatic esophageal cancer: where do we need to improve?

Expert Opin Pharmacother 2018 Dec 7:1-10. Epub 2018 Dec 7.

a Department of Medicine , Perlmutter Cancer Center, NYU Langone Medical Center , New York , NY , USA.

Introduction: Esophageal cancer is a heterogeneous cancer comprised of differing cells of origin, molecular changes, and immune microenvironments. To date, most advances have been made in chemotherapy regimens where a one-size-fits-all approach is used. As a result, there remains a lack of tailored treatment options for such a heterogeneous cancer. Read More

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December 2018

Novel-miR-4885 Promotes Migration and Invasion of Esophageal Cancer Cells Through Targeting CTNNA2.

DNA Cell Biol 2018 Dec 8. Epub 2018 Dec 8.

1 Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University , Nanjing, Jiangsu, P.R. China .

Esophageal cancer is one of the most common cancers worldwide. It is critical to find early diagnostic biomarkers for esophageal cancer. MicroRNAs (miRNAs) play important regulatory roles in occurrence and development of esophageal cancer, which has the diagnostic and prognostic values. Read More

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December 2018

Pancreatic Acinar Metaplasia in Distal Esophageal Biopsies Is Associated With Chronic Nonsteroidal Anti-inflammatory Drug Use.

Arch Pathol Lab Med 2018 Dec 10. Epub 2018 Dec 10.

From the Department of Pathology and Laboratory Medicine (Drs Salihi, Jaitly, Saulino, Everett, and Younes) and the Department of Medicine, Section of Gastroenterology, Hepatology and Nutrition (Drs DuPont and Ertan), University of Texas Health Science Center at Houston McGovern Medical School and Memorial Hermann Hospital-TMC, Houston, Texas.

Context.—: The cause of pancreatic acinar metaplasia (PAM) at the distal esophagus/esophagogastric junction is still controversial. Whereas some authors believe it is congenital, others believe it is acquired because of inflammation of the gastric cardia, and more recently it was proposed to be due to chronic proton pump inhibitor use based on a study in rats. Read More

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December 2018

Laparoscopic sleeve gastrectomy and gastroesophageal reflux.

Rom J Intern Med 2018 Dec;56(4):227-232

"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

The prevalence of obesity is rising, becoming a medical problem worldwide. Also GERD incidence is higher in obese patients compared with normal weight, with an increased risk of 2.5 of developing symptoms and erosive esophagitis. Read More

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December 2018

Positive endoscopic and ultrasonographic findings in symptom-diagnosed functional gastrointestinal disorder patients: Data from a Chinese cross-sectional study.

J Dig Dis 2018 Dec 5. Epub 2018 Dec 5.

Division of Gastroenterology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Objective: Few studies have systematically assessed symptom-based diagnosis of functional gastrointestinal disorders (FGIDs) in China. This study aimed to evaluate the positive endoscopic and ultrasonographic findings in symptom-based FGID patients.

Methods: Adult patients with gastrointestinal symptoms but not red flag symptoms who were empirically diagnosed with FGIDs underwent upper and/or lower gastrointestinal endoscopy based on their symptoms. Read More

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December 2018
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Changes in the Distal Esophageal Microbiota in Chinese Patients with Reflux Esophagitis.

J Dig Dis 2018 Dec 5. Epub 2018 Dec 5.

Digestive Department, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Objective: Changes in microbiota structure in the distal esophagus may be associated with the pathogenesis of gastroesophageal reflux disease. The composition of the distal esophageal microbiota between Chinese patients and healthy volunteers was compared through metagenomic high-throughput DNA sequencing and bioinformatic analyses.

Methods: Healthy volunteers (HV) and patients with reflux esophagitis (RE) were enrolled. Read More

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December 2018
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