52,088 results match your criteria Escherichia Coli Infections


An alternative strategy for combination therapy: Interactions between polymyxin B and non-antibiotics.

Int J Antimicrob Agents 2018 Sep 18. Epub 2018 Sep 18.

Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Centre, Rotterdam, The Netherlands. Electronic address:

Antimicrobial resistance is increasing and few new antibiotics are in the development pipeline. Alternative strategies to treat infectious diseases such as combination therapy are urgently needed. Polymyxin B is a neglected and disused antibiotic with moderate antibacterial activity, and in this study we aimed to find synergistic interactions between polymyxin B and a wide range of non-antibiotics to improve its efficacy. Read More

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September 2018

Microenvironment-Responsive Magnetic Nanocomposites Based on Silver Nanoparticles/Gentamicin for Enhanced Biofilm Disruption by Magnetic Field.

ACS Appl Mater Interfaces 2018 Sep 21. Epub 2018 Sep 21.

Biofilms contribute to persistent bacterial infections as well as formidable resistances to conventional antibiotics. However, it is still a major challenge to establish an advanced antibacterial nanoplatform that can efficiently eradicate biofilms while overcoming bacterial resistances. Taking advantage of the stimuli-responsive technique and the magnetic guidance strategy, here we present a highly efficient nanoplatform for planktonic inactivation and biofilm disruption. Read More

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September 2018

Synergistic and bactericidal activities of mecillinam, amoxicillin and clavulanic acid combinations against ESBL-producing Escherichia coli in 24-h time-kill experiments.

Int J Antimicrob Agents 2018 Sep 17. Epub 2018 Sep 17.

Department of Medical Sciences, Section of Infectious Diseases, Uppsala University, Uppsala, Sweden. Electronic address:

This study aimed to evaluate the potential synergistic and bactericidal effects of mecillinam in combinations with amoxicillin and clavulanic acid against ESBL-producing Escherichia coli. Eight clinical isolates with varying susceptibility to mecillinam (MICs 0.125 to >256 mg/L) and high-level resistance to amoxicillin (MICs >256 mg/L) were used. Read More

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September 2018

Streamlined generation of plant virus infectious clones using the pLX mini binary vectors.

J Virol Methods 2018 Sep 17. Epub 2018 Sep 17.

Agricultural Biotechnology Research Center, Academia Sinica, 11529 Taipei, Taiwan, China.

Recent metagenomic surveys have provided unprecedented amounts of data which have revolutionized our understanding of virus evolution and diversity. Infectious clones are powerful tools to aid the biological characterization of viruses. We have recently described the pLX vectors, a set of mini binary T-DNA vectors (~3 kb) that includes strong bacterial terminators and a minimal replicon from the broad-host-range plasmid pBBR1, which autonomously replicate in both Escherichia coli and Agrobacterium tumefaciens. Read More

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September 2018

Etiology and clinical manifestations of bacterial liver abscess: A study of 102 cases.

Medicine (Baltimore) 2018 Sep;97(38):e12326

Department of Infectious Diseases, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.

This study aimed to analyze the clinical manifestations of patients with pyogenic liver abscess and characteristics of pathogenic that caused their infections, in order to provide guidance for the identification of the pathogens that cause liver abscess and selection of antibiotics for treatment of this disease.In the present study, the clinical characteristics, laboratory results, as well as the species and drug resistance of pathogens in patients with bacterial liver abscesses admitted to our hospital from January 2013 to December 2015 were retrospectively analyzed. The patients were treated by ultrasound or CT-guided percutaneous portal vein catheterization and drainage combined with intravenous infusion of antibiotics (the third-generation cephalosporins, the coformulation of carbapenem and dehydropeptidase-I inhibitors, or the coformulation of tazobactam and piperacillin). Read More

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September 2018

MinION nanopore sequencing identifies the position and structure of bacterial antibiotic resistance determinants in a multidrug-resistant strain of enteroaggregative Escherichia coli.

Microb Genom 2018 Sep 20. Epub 2018 Sep 20.

Public Health England, UK.

The aim of this study was to use single-molecule, nanopore sequencing to explore the genomic environment of the resistance determinants in a multidrug-resistant (MDR) strain of enteroaggregative Escherichia coli serotype O51 : H30, sequence type (ST) 38. Sequencing was performed on the MinION Flow cell MIN-106 R9.4. Read More

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September 2018

Cytotoxic Necrotizing Factor 1 Downregulates CD36 Transcription in Macrophages to Induce Inflammation During Acute Urinary Tract Infections.

Front Immunol 2018 31;9:1987. Epub 2018 Aug 31.

Key Laboratory of Immune Microenvironment and Disease of the Educational Ministry of China, Tianjin Key Laboratory of Cellular and Molecular Immunology, Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.

Urinary tract infections (UTIs) caused by uropathogenic (UPEC) induce cystitis, pyelonephritis, and can cause kidney scarring and failure if inflammation is not under control. The detailed effects of cytotoxic necrotizing factor 1 (CNF1), the key UPEC toxin, on the pathogenicity of UPEC remain unclear. CD36 is an important scavenger receptor, responsible for pathogen and apoptotic cell clearance, and plays an essential role in host immune defense and homeostasis. Read More

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The NF-κB Inhibitor, IMD-0354, Affects Immune Gene Expression, Bacterial Microbiota and Infection in Midgut.

Front Physiol 2018 31;9:1189. Epub 2018 Aug 31.

Laboratório de Bioquímica e Fisiologia de Insetos, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz (IOC/FIOCRUZ), Rio de Janeiro, Brazil.

is an insect vector of , the causative agent of Chagas disease in Latin America. Nuclear factor-B (NF-B) transcription factors (TF) are conserved components of the innate immune system in several multicellular organisms including insects. The drug IMD-0354 [-(3,5-bis-trifluoromethyl-phenyl)-5-chloro-2-hydroxy-benzamide] is a selective inhibitor of IB kinases. Read More

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Phosphoethanolamine cellulose enhances curli-mediated adhesion of uropathogenic to bladder epithelial cells.

Proc Natl Acad Sci U S A 2018 Sep 19. Epub 2018 Sep 19.

Department of Chemistry, Stanford University, Stanford, CA 94305;

Uropathogenic (UPEC) are the major causative agents of urinary tract infections, employing numerous molecular strategies to contribute to adhesion, colonization, and persistence in the bladder niche. Identifying strategies to prevent adhesion and colonization is a promising approach to inhibit bacterial pathogenesis and to help preserve the efficacy of available antibiotics. This approach requires an improved understanding of the molecular determinants of adhesion to the bladder urothelium. Read More

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September 2018

Diarrhoeagenic Escherichia coli and Escherichia albertii in Brazil: pathotypes and serotypes over a 6-year period of surveillance.

Epidemiol Infect 2018 Sep 19:1-9. Epub 2018 Sep 19.

Adolfo Lutz Institute-Centre of Bacteriology (National Reference Laboratory for Escherichia coli Enteric Infections),Sao Paulo,Brazil.

Diarrhoeagenic Escherichia coli (DEC) is a leading cause of infectious diarrhoea worldwide. In recent years, Escherichia albertii has also been implicated as a cause of human enteric diseases. This study describes the occurrence of E. Read More

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September 2018

Spermine and oxacillin stress response on the cell wall synthesis and the global gene expression analysis in Methicillin-resistance Staphylococcus aureus.

Genes Genomics 2018 Sep 18. Epub 2018 Sep 18.

Department of Clinical Laboratory and Nutritional Sciences, University of Massachusetts, Weed Hall 320, Lowell, MA, 01854-5125, USA.

Methicillin-resistant Staphylococcus aureus (MRSA) is a rapidly emerging bacteria causing infection, which has developed resistance to most of the beta-lactam antibiotics because of newly acquired low-affinity penicillin-binding protein (PBP2a), which can continue to build the cell wall when beta-lactams block other PBPs. Exogenous spermine exerts a dose-dependent inhibition effect on the growth of Escherichia coli, Salmonella enterica serovar, and S. aureus. Read More

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September 2018

International high-risk clonal lineages of CTX-M-producing Escherichia coli F-ST648 in free-roaming cats, South America.

Infect Genet Evol 2018 Sep 15. Epub 2018 Sep 15.

Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil; Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil. Electronic address:

The dissemination of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli belonging to high-virulent pandemic lineages has become a global problem with serious consequences for public health worldwide. In this regard, E. coli lineages belonging to the sequence type ST648, which are mostly associated with nosocomial infections, have begun to be reported in animals. Read More

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September 2018

Poly(silsesquioxanes) and poly(siloxanes) grafted with N-acetylcysteine for eradicating mature bacterial biofilms in water environment.

Colloids Surf B Biointerfaces 2018 Sep 10;172:627-634. Epub 2018 Sep 10.

Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363 Łódź, Poland. Electronic address:

Bacteria adapt to their living environment forming organised biofilms. The survival strategy makes them more resistant to disinfectants, which results in acute biofilm-caused infections, secondary water pollution by biofilm metabolites and bio-corrosion. New, efficient and environmentally friendly strategies must be developed to solve this problem. Read More

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September 2018

Non-O157 Shiga Toxin-Producing Escherichia coli - a Poorly Appreciated Enteric Pathogen: Systematic Review.

Int J Infect Dis 2018 Sep 14. Epub 2018 Sep 14.

University of Texas, McGovern School of Medicine, Houston, USA; University of Houston, Houston, USA; University of Texas, School of Public Health, Houston, USA; University of Texas, School of Public Health and Baylor College of Medicine, Houston, USA. Electronic address:

Non-O157 strains of STEC are more common causes of acute diarrhea than the better-known O157 strains and have the potential for large outbreaks. This systematic review of the literature identified 129 serogroups as well as 262 different O and H antigen combinations of Shiga-toxin-producing Escherichia coli (STEC) in cases of epidemic and sporadic disease worldwide. Removing results from a single large outbreak of STEC O104:H4 in Germany and France in 2011, the reported frequency of dysenteric illness in patients was 119 of 464 (26%) for epidemic disease and 646 of 2,588 (25%) for sporadic cases. Read More

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September 2018

Predictive factors for multidrug-resistant gram-negative bacteria among hospitalised patients with complicated urinary tract infections.

Antimicrob Resist Infect Control 2018 14;7:111. Epub 2018 Sep 14.

1Department of Infectious Diseases, Hospital Universitari de Bellvitge, Institut Català de la Salut (ICS-HUB), Feixa Llarga s/n, L'Hospitalet de Llobregat, 08907 Barcelona, Spain.

Background: Patients with complicated urinary tract infections (cUTIs) frequently receive broad-spectrum antibiotics. We aimed to determine the prevalence and predictive factors of multidrug-resistant gram-negative bacteria in patients with cUTI.

Methods: This is a multicenter, retrospective cohort study in south and eastern Europe, Turkey and Israel including consecutive patients with cUTIs hospitalised between January 2013 and December 2014. Read More

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September 2018

Association between TLR4 polymorphisms (896 A>G, 1196 C>T, - 2570 A>G, - 2081 G>A) and virulence factors in uropathogenic Escherichia coli.

Clin Exp Med 2018 Sep 15. Epub 2018 Sep 15.

Facultad de Ciencias Químico Bilógicas, Universidad Autónoma de Guerrero, Lázaro Cárdenas S/N Col. La Haciendita, C.P. 39090, Chilpancingo, Guerrero, Mexico.

Escherichia coli is the main etiological agent of urinary tract infections. Its virulence factors are important during the initial interaction stage with the host as they enable colonization of urinary tract tissues. The genetic markers evidencing susceptibility to develop recurrent infections have been previously described. Read More

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September 2018

Evaluation of the ability of colistin, amoxicillin (components of Potencil ), and fluoroquinolones to attenuate bacterial endotoxin- and Shiga exotoxin-mediated cytotoxicity-In vitro studies.

J Vet Pharmacol Ther 2018 Sep 15. Epub 2018 Sep 15.

Virbac, Carros, France.

Escherichia coli is one of the major pathogens in humans and animals causing localized and systemic infections, which often lead to acute inflammation, watery diarrhea, and hemorrhagic colitis. Bacterial lipopolysaccharide (LPS) and Shiga exotoxins (Stx) are mostly responsible for such clinical signs. Therefore, highly effective treatment of E. Read More

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September 2018

Routine antibiotic therapy in dogs increases the detection of antimicrobial-resistant faecal Escherichia coli.

J Antimicrob Chemother 2018 Sep 11. Epub 2018 Sep 11.

Department of Epidemiology and Population Health, Institute of Infection and Global Health, University of Liverpool, Leahurst Campus, Neston, UK.

Background: Antimicrobial resistance (AMR) is a critical health problem, with systemic antimicrobial therapy driving development of AMR across the host spectrum.

Objectives: This study compares longitudinal carriage, at multiple timepoints, of AMR faecal Escherichia coli in dogs undergoing routine antimicrobial treatment.

Methods: Faecal samples (n = 457) from dogs (n = 127) were examined pretreatment, immediately after treatment and 1 month and 3 months post-treatment with one of five antimicrobials. Read More

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September 2018
2 Reads

Resistance pattern and maternal knowledge, attitude and practices of suspected Diarrheagenic among children under 5 years of age in Addis Ababa, Ethiopia: cross sectional study.

Antimicrob Resist Infect Control 2018 12;7:110. Epub 2018 Sep 12.

1Department of Microbiology, St. Paul's Hospital Millennium Medical College, P.O.Box 1271, Addis Ababa, Ethiopia.

Background: Diarrheal illness remains one of the leading causes of morbidity and mortality among children under 5 years of age worldwide, especially in developing countries. Diarrheagenic (DEC) is the major cause of gastroenteritis in children in the developing world and is associated with high resistance levels to antibiotics. The aims of this study were to isolate and determine susceptibility patterns of DEC among children under 5 years of age with acute diarrhea and to assess maternal knowledge, attitude and practice towards childhood diarrhea. Read More

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September 2018
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Clinical application of a multiplex genetic pathogen detection system remaps the aetiology of diarrhoeal infections in Shanghai.

Gut Pathog 2018 11;10:37. Epub 2018 Sep 11.

1Department of Laboratory Medicine, Huadong Hospital, Affiliated with Fudan University, Shanghai, 200040 China.

Background: Culture-based diagnostic methods cannot achieve rapid and precise diagnoses for the identification of multiple diarrhoeal pathogens (DPs). A high-throughput multiplex genetic detection system (HMGS) was adapted and evaluated for the simultaneous identification and differentiation of infectious DPs and a broad analysis of DP infection aetiology.

Results: DP-HMGS was highly sensitive and specific for DP detection compared with culture-based techniques and was similar to singleplex real-time PCR. Read More

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September 2018

Susceptibility to ceftobiprole of respiratory-tract pathogens collected in the United Kingdom and Ireland during 2014-2015.

Infect Drug Resist 2018 28;11:1309-1320. Epub 2018 Aug 28.

Basilea Pharmaceutica International Ltd., Basel 4005, Switzerland,

Purpose: Lower respiratory tract infections (LRTIs) can cause significant morbidity and mortality and are becoming increasingly difficult to treat because of the growing prevalence of resistance to conventional antimicrobial agents. This study aimed to assess the current in vitro susceptibility of respiratory tract pathogens collected from the UK and Ireland to ceftobiprole, an advanced-generation cephalosporin, as compared with other antibiotics.

Methods: Pathogens isolated from patients with LRTIs were analyzed as part of the British Society for Antimicrobial Chemotherapy Antimicrobial Resistance Surveillance Programme during 2014-2015. Read More

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Effects of 462 nm Light-Emitting Diode on the Inactivation of and a Multidrug-Resistant by Tetracycline Photoreaction.

J Clin Med 2018 Sep 12;7(9). Epub 2018 Sep 12.

Department of Biotechnology, Ming-Chuan University, Gui-Shan 33343, Taiwan.

The adaptability of bacterial resistance to antibiotics contributes to its high efficiency during evolution. Tetracycline (TC) is a broad-spectrum antimicrobial agent. Chromatographic analyses and mass spectrometry were used to study the effects of the light illumination of a 462 nm light-emitting diode (LED) on the conformational changes of TC in a phosphate buffer solution (PBS, pH 7. Read More

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September 2018

Observations of Bacterial Biofilm on Ureteral Stent and Studies on the Distribution of Pathogenic Bacteria and Drug Resistance.

Urol Int 2018 Sep 13:1-7. Epub 2018 Sep 13.

Department of Urology, Yongchuan Hospital, Chongqing Medical University, Chongqing, China.

Objective: This study aims to observe the morphological characteristics of bacterial biofilm on the surface of ureteral stents and analyze distribution characteristics of pathogens on the bacterial biofilm and drug resistance.

Methods: Ureteral stents were sampled from 129 patients. A scanning electron microscope was used to observe the morphological characteristics of bacterial biofilms, and the Congo red medium was applied to screen bacterial biofilm strains on the renal pelvis section, ureter section, and bladder section respectively. Read More

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September 2018
1 Read

The Emerging Resistance in Nosocomial Urinary Tract Infections: From the Pediatrics Perspective.

Mediterr J Hematol Infect Dis 2018 1;10(1):e2018055. Epub 2018 Sep 1.

Dr. Behçet Uz Children's Hospital, İzmir, Turkey.

Background: Healthcare-associated infections results in increased health care costs and mortality. There are limited studies concerning the distribution of the etiologic agents and the resistance patterns of the microorganisms causing healthcare-associated urinary tract infections (HA-UTI) in pediatric settings.

Objectives: The aim of this study was to evaluate the distribution and antibiotic susceptibility patterns of pathogens causing HA-UTI in children. Read More

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September 2018

Prevalence of Multidrug-Resistant Isolated from Drinking Water Sources.

Int J Microbiol 2018 19;2018:7204013. Epub 2018 Aug 19.

Department of Bacteriology, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.

The control of infectious diseases is badly endangered by the rise in the number of microorganisms that are resistant to antimicrobial agents. This is because infections caused by resistant microorganisms often fail to respond to conventional treatment, resulting in prolonged illness and greater risk of death. Antimicrobial-resistant bacteria are also present in various water sources. Read More

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August 2018
3 Reads

Effect of Piperacillin-Tazobactam vs Meropenem on 30-Day Mortality for Patients With E coli or Klebsiella pneumoniae Bloodstream Infection and Ceftriaxone Resistance: A Randomized Clinical Trial.

JAMA 2018 09;320(10):984-994

University of Queensland, UQ Centre for Clinical Research, Brisbane, Queensland, Australia.

Importance: Extended-spectrum β-lactamases mediate resistance to third-generation cephalosporins (eg, ceftriaxone) in Escherichia coli and Klebsiella pneumoniae. Significant infections caused by these strains are usually treated with carbapenems, potentially selecting for carbapenem resistance. Piperacillin-tazobactam may be an effective "carbapenem-sparing" option to treat extended-spectrum β-lactamase producers. Read More

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September 2018

A spatial and temporal analysis of risk factors associated with sporadic Shiga toxin-producing Escherichia coli O157 infection in England between 2009 and 2015.

Epidemiol Infect 2018 Sep 12:1-12. Epub 2018 Sep 12.

National Institute for Health Research Health Protection Research Unit (NIHR HPRU) in Gastrointestinal Infections,England,UK.

Infection with STEC O157 is relatively rare but has potentially serious sequelae, particularly for children. Large outbreaks have prompted considerable efforts designed to reduce transmission primarily from food and direct animal contact. Despite these interventions, numbers of infections have remained constant for many years and the mechanisms leading to many sporadic infections remain unclear. Read More

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September 2018

RS sample: Can be guide for empirical treatment of haematological malignancy patients?

Microb Pathog 2018 Sep 8;125:164-167. Epub 2018 Sep 8.

Ankara University, Central Laboratory of Biotechnology Institute, Ankara, Turkey.

Neutropenia due to intensive chemotherapy in haematological malignancy patients leaves the host vulnerable and makes them susceptible to infections. Infections are the most important cause of morbidity and mortality especially in haematological malignancy and chemotherapy patients. In addition, the use of multiple or inappropriate antibiotics leads to the development of resistant microorganisms. Read More

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September 2018
1 Read

Retrospective Evaluation of Clinical Signs and Gross Pathologic Findings in Birds Infected With Mycobacterium genavense.

J Avian Med Surg 2018 Sep;32(3):194-204

Mycobacterium genavense is regarded as the primary cause of mycobacteriosis in passerine and psittacine birds kept in captivity. Mycobacterium genavense is a potential zoonotic pathogen; therefore, early antemortem detection in birds is needed. In humans, infections with M genavense are found predominantly in immunocompromised people. Read More

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September 2018
1 Read

Novel trimethoprim resistance gene dfrA34 identified in Salmonella Heidelberg in the USA.

J Antimicrob Chemother 2018 Sep 10. Epub 2018 Sep 10.

Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA, USA.

Background: Trimethoprim/sulfamethoxazole is a synthetic antibiotic combination recommended for the treatment of complicated non-typhoidal Salmonella infections in humans. Resistance to trimethoprim/sulfamethoxazole is mediated by the acquisition of mobile genes, requiring both a dfr gene (trimethoprim resistance) and a sul gene (sulfamethoxazole resistance) for a clinical resistance phenotype (MIC ≥4/76 mg/L). In 2017, the CDC investigated a multistate outbreak caused by a Salmonella enterica serotype Heidelberg strain with trimethoprim/sulfamethoxazole resistance, in which sul genes but no known dfr genes were detected. Read More

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September 2018
2 Reads

Age does not influence the disease course in a mouse model of serotype 3 meningitis.

Immun Ageing 2018 7;15:20. Epub 2018 Sep 7.

1Institute of Neuropathology, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany.

In order to elucidate the causes for the increased mortality of aged patients with bacterial central nervous system (CNS) infections, we compared the course of () meningitis in aged and young mice. Aged (21.2 ± 3. Read More

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September 2018
1 Read

Conserved collateral antibiotic susceptibility networks in diverse clinical strains of Escherichia coli.

Nat Commun 2018 Sep 10;9(1):3673. Epub 2018 Sep 10.

Department of Pharmacy, Faculty of Health Sciences, UiT The Arctic University of Norway, 9037, Tromsø, Norway.

There is urgent need to develop novel treatment strategies to reduce antimicrobial resistance. Collateral sensitivity (CS), where resistance to one antimicrobial increases susceptibility to other drugs, might enable selection against resistance during treatment. However, the success of this approach would depend on the conservation of CS networks across genetically diverse bacterial strains. Read More

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September 2018
1 Read

Cellulose acetate - essential oil nanocapsules with antimicrobial activity for biomedical applications.

Colloids Surf B Biointerfaces 2018 Aug 31;172:471-479. Epub 2018 Aug 31.

Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Polizu Street No. 1-7, Bucharest, 011061, Romania; Department of Microbiology and Immunology, Faculty of Biology, University of Bucharest, Aleea Portocalelor, No. 1-3, Bucharest, 060101, Romania. Electronic address:

This study aimed to obtain bioactive nanosystems by combining cellulose acetate with three selected essential oils (EOs) to create spherical nanocapsules (NCs) using the solvent/anti-solvent technique. The biological activity of the obtained NCs was promoted by the use of some antimicrobial EOs: Peppermint, Cinnamon and lemongrass which were grafted on the cellulose acetate molecules. Due to their chemistry, such as long hydrocarbon tails and heads with functional groups these EOs were playing also the role of surfactant-like substance facilitating the formation of NCs. Read More

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August 2018
1 Read

Genotypic and phenotypic characteristics of Escherichia coli involved in transfusion-transmitted bacterial infections: implications for preventive strategies.

Transfusion 2018 Aug;58(8):1940-1950

INSERM UMR1137, IAME, Paris Diderot University, Faculty of Medicine Xavier Bichat, Paris, France.

Background: Transfusion-transmitted bacterial infections (TTBIs) are the main residual infectious complications of transfusions. Escherichia coli and platelet (PLT) concentrates may be epidemiologically associated, leading to severe, if not lethal, TTBIs. We investigated the genotypic and phenotypic reasons for this clinically deleterious combination. Read More

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August 2018
2 Reads

Detection of Plasmid-Mediated Genes Among the Clinical Quinolone-Resistant Strains Isolated in Tehran, Iran.

Open Microbiol J 2018 31;12:248-253. Epub 2018 Jul 31.

Molecular Biology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Background: is one of the most important bacterial agents to cause urinary tract infections. Inappropriate and unnecessary administration of antibiotics has led to an increase in the appearance of multidrug-resistant isolates, limiting treatment options. The increase in a number of resistant strains of bacteria is a major concern of health authorities worldwide. Read More

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July 2018
3 Reads

Antimicrobial prophylaxis for transurethral resection of bladder tumor: A retrospective comparison of preoperative single-dose administration of piperacillin and tazobactam/piperacillin.

J Infect Chemother 2018 Sep 4. Epub 2018 Sep 4.

Department of Urology, The Jikei University, School of Medicine, Japan.

We aimed to clarify prophylactic antimicrobial effects of single-dose piperacillin (PIPC) for perioperative infections in the transurethral resection of bladder tumor (TURBT) in comparison with those of single-dose tazobactam/piperacillin (TAZ/PIPC) through a retrospective analysis. We analyzed data from 192 TURBT patients treated with single-dose (4 g) intravenous PIPC (P group) between April 2015 and April 2017. For comparison, we analyzed data from 50 TURBT patients treated with single-dose (4. Read More

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September 2018

Recent developments of quinolone-based derivatives and their activities against Escherichia coli.

Eur J Med Chem 2018 Sep 1;157:1223-1248. Epub 2018 Sep 1.

Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, PR China. Electronic address:

Escherichia coli (E. coli) is the most common pathogen in both hospital and community settings, and is capable of causing infections that can lead to serious consequences. Quinolones, one of the most common antibiotics in clinical use, are effective weapons to treat E. Read More

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September 2018
6 Reads

Hospital-acquired colonization and infections in a Vietnamese intensive care unit.

PLoS One 2018 7;13(9):e0203600. Epub 2018 Sep 7.

Hospital for Tropical Diseases, Wellcome Trust Asia Programme, Oxford University Clinical Research Unit (OUCRU), Ho Chi Minh City, Vietnam.

Data concerning intensive care unit (ICU)-acquired bacterial colonization and infections are scarce from low and middle-income countries (LMICs). ICU patients in these settings are at high risk of becoming colonized and infected with antimicrobial-resistant organisms (AROs). We conducted a prospective observational study at the Ho Chi Minh City Hospital for Tropical Diseases, Vietnam from November 2014 to January 2016 to assess the ICU-acquired colonization and infections, focusing on the five major pathogens in our setting: Staphylococcus aureus (S. Read More

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September 2018
3 Reads

Antimicrobial Potential of Silver Nanoparticles Synthesized Using Medicinal Herb Coptidis rhizome.

Molecules 2018 Sep 5;23(9). Epub 2018 Sep 5.

Institute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si 24252, Gangwon-do, Korea.

contains several alkaloids that are bioactive agents of therapeutic value. We propose an eco-friendly method to synthesize biocompatible silver nanoparticles (AgNPs) using the aqueous extract of . Silver ions were reduced to AgNPs using the aqueous extract of , indicating that can be used for the biosynthesis of AgNPs. Read More

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September 2018
1 Read

Antimicrobial Potential of Silver Nanoparticles Synthesized Using Medicinal Herb .

Molecules 2018 Sep 5;23(9). Epub 2018 Sep 5.

Institute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si 24252, Gangwon-do, Korea.

contains several alkaloids that are bioactive agents of therapeutic value. We propose an eco-friendly method to synthesize biocompatible silver nanoparticles (AgNPs) using the aqueous extract of . Silver ions were reduced to AgNPs using the aqueous extract of , indicating that can be used for the biosynthesis of AgNPs. Read More

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September 2018

Bone and joint infections in infants under three months of age.

Acta Paediatr 2018 Sep 6. Epub 2018 Sep 6.

Paediatric Department-Division of infectious disease, Armand Trousseau Hospital, AP-HP, Paris, France.

Aim: Studies on bone and joint infections (BJI) in infants under three months are rare. We described the clinical and paraclinical features and outcomes of infants hospitalised with BJI under three months of age.

Methods: The French National Hospital Discharge Database provided data on BJIs in infants under three months of age from January 2004 to 2015 in three Parisian Paediatric teaching hospitals. Read More

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September 2018
3 Reads

Characterization of Spleen Transcriptome and Immunity Against Avian Colibacillosis After Immunization With Recombinant Attenuated Vaccine Strains.

Front Vet Sci 2018 21;5:198. Epub 2018 Aug 21.

Department of Food Science and Human Nutrition, Iowa State University, Ames, IA, United States.

Avian pathogenic (APEC) causes extraintestinal infections in poultry. Vaccines targeting APEC in chickens have been partially successful, but many lack heterologous protection. Recombinant attenuated vaccine (RASV) strains can induce broad immunity against and be modified to deliver antigens. Read More

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August 2018
1 Read

Detection of high-risk carbapenem-resistant Klebsiella pneumoniae and Enterobacter cloacae isolates using volatile molecular profiles.

Sci Rep 2018 Sep 5;8(1):13297. Epub 2018 Sep 5.

Geisel School of Medicine, Dartmouth College, Hanover, NH, 03755, United States.

Infections caused by carbapenem-resistant Enterobacteriaceae (CRE) are alarming in the clinical setting, as CRE isolates often exhibit resistance to most clinically-available antibiotics. Klebsiella pneumoniae carbapenemase (KPC) is the most common carbapenemase carried by CRE in North America and Europe, frequently detected in isolates of K. pneumoniae, Escherichia coli, and Enterobacter cloacae. Read More

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September 2018

Antibiotic susceptibility of wound swab isolates in a tertiary hospital in Southwest Nigeria.

Ann Afr Med 2018 Jul-Sep;17(3):110-116

Department of Medical Microbiology and Parasitology, College of Health Sciences, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria.

Background: Wounds are commonly encountered in the clinical practice. Microbacterial colonization and infection negatively affect wound outcomes. With increasing emergence of antibiotic-resistant strains, it is essential to determine local patterns of wound microbiological profile and antibiotic susceptibility to guide rational empirical antibiotic use. Read More

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September 2018

Mouse model of Gram-negative prosthetic joint infection reveals therapeutic targets.

JCI Insight 2018 Sep 6;3(17). Epub 2018 Sep 6.

Department of Orthopaedic Surgery.

Bacterial biofilm infections of implantable medical devices decrease the effectiveness of antibiotics, creating difficult-to-treat chronic infections. Prosthetic joint infections (PJI) are particularly problematic because they require prolonged antibiotic courses and reoperations to remove and replace the infected prostheses. Current models to study PJI focus on Gram-positive bacteria, but Gram-negative PJI (GN-PJI) are increasingly common and are often more difficult to treat, with worse clinical outcomes. Read More

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September 2018

MCR-1 Confers Cross-Resistance to Bacitracin, a Widely Used In-Feed Antibiotic.

mSphere 2018 Sep 5;3(5). Epub 2018 Sep 5.

Department of Animal Science, The University of Tennessee, Knoxville, Tennessee, USA

Extensive use of colistin in food animals is deemed a major driving force for the emergence and transmission of However, a non-colistin usage factor(s) contributing to mobile colistin resistance may also exist in animal production systems. Given that polymyxin, a bacterium-derived peptide antibiotic, has been successfully used as a surrogate to study bacterial resistance to antimicrobial peptides (AMPs), acquisition of MCR-1 may confer cross-resistance to the unrelated AMPs implicated in practical applications. To test this, we first constructed recombinant strains differing only in the presence or absence of functional MCR-1. Read More

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September 2018

Rapid detection and discrimination of chromosome- and MCR-plasmid-mediated resistance to polymyxins by MALDI-TOF MS in Escherichia coli: the MALDIxin test.

J Antimicrob Chemother 2018 Sep 1. Epub 2018 Sep 1.

MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Faculty of Natural Sciences, Imperial College London, London, UK.

Background: Polymyxins are currently considered a last-resort treatment for infections caused by MDR Gram-negative bacteria. Recently, the emergence of carbapenemase-producing Enterobacteriaceae has accelerated the use of polymyxins in the clinic, resulting in an increase in polymyxin-resistant bacteria. Polymyxin resistance arises through modification of lipid A, such as the addition of phosphoethanolamine (pETN). Read More

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September 2018
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Prevention of bacterial colonization on non-thermal atmospheric plasma treated surgical sutures for control and prevention of surgical site infections.

PLoS One 2018 5;13(9):e0202703. Epub 2018 Sep 5.

Department of Biomedical Engineering, Faculty of Engineering and Architecture, İzmir Katip Çelebi University, Çiğli, İzmir, Turkey.

Surgical site infections have a remarkable impact on morbidity, extended hospitalization and mortality. Sutures strongly contribute to development of surgical site infections as they are considered foreign material in the human body. Sutures serve as excellent surfaces for microbial adherence and subsequent colonization, biofilm formation and infection on the site of a surgery. Read More

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September 2018