59,803 results match your criteria Escherichia Coli Infections

Spectrum of uropathogens and their susceptibility to antimicrobials in pregnant women: a retrospective analysis of 5-year hospital data.

J Int Med Res 2021 May;49(5):3000605211006540

Department of Internal Medicine, School of Medicine, The University of Jordan, Amman, Jordan.

Objective: Urinary tract infections (UTI) are common during pregnancy. Identification of antimicrobial susceptibility patterns of microorganisms in pregnant women is important to select the most appropriate antimicrobial. We assessed common uropathogens in pregnant women with UTI and antimicrobial susceptibility, to guide empirical antibiotic selection. Read More

View Article and Full-Text PDF

Activity of Fosfomycin and Nitrofurantoin Against Contemporary Pathogens Isolated from Indian Tertiary Care Hospitals.

Microb Drug Resist 2021 May 13;27(5):678-684. Epub 2020 Oct 13.

Wockhardt Research Centre, D4 MIDC, Aurangabad, India.

In India, multidrug resistance in community and hospital associated Gram-negative pathogens has increased sharply over the past few years. In the absence of novel oral multidrug resistant-pathogen active therapies, the therapeutic situation with regard to community infections is even more challenging. Hence, the focus is now shifting toward potentially expanding the utility of older antibiotics such as fosfomycin and nitrofurantoin beyond their approved pathogen coverage. Read More

View Article and Full-Text PDF

Single-dose intravesical amikacin instillation for pyocystis in a patient with autonomic dysreflexia: A case report.

J Spinal Cord Med 2021 May 13:1-4. Epub 2021 May 13.

College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, USA.

Context: Pyocystis is an infection of the epithelium of the bladder and a frequent complication of anuria. Patients with spinal cord injury (SCI) at the sixth thoracic vertebra (T6) or higher are at a greater risk for autonomic dysreflexia (AD), which can be induced by infections such as pyocystis. Cases of pyocystis treatment with aminoglycoside instillations have been reported in the literature. Read More

View Article and Full-Text PDF

In vitro evaluation of the anti-pathogenic activity of Okoubaka aubrevillei on the human gastrointestinal tract.

Z Gastroenterol 2021 May 12;59(5):423-437. Epub 2021 May 12.

Institute of Integrative Medicine, University of Witten/Herdecke, Germany.

Background:   is used in traditional West African medicine and in homeopathy for treatment and prevention of several gastrointestinal problems. The aim of this study was to evaluate the effect of repeated doses of two products (10 % ethanolic tincture, mother tincture (MT); 3 decimal potency, 3X) on the microbial activity of physiological human colon microbiota using a Simulator of the Human Intestinal Microbial Ecosystem (SHIME) and to investigate any preventive effect against infections with diarrhea-causing pathogens.

Methods:  Upon inoculation with fecal microbiota from a healthy donor, 4 parallel proximal colon compartments of the SHIME were treated either with MT, 3X, ethanol control or blank control for 7 days. Read More

View Article and Full-Text PDF

Cytotoxic effect of galvanically coupled magnesium-titanium particles on Escherichia coli.

J Biomed Mater Res B Appl Biomater 2021 May 12. Epub 2021 May 12.

Department of Biomedical and Chemical Engineering, College of Engineering and Computer Science, Syracuse University, Syracuse, New York, USA.

Orthopedic device-related infections (ODRIs) are difficult to control due to microbial biofilm formation and associated with high-level resistance to conventional antibiotics. In many cases, the only treatment option for ODRI is explantation. Previous studies have shown that application of cathodic potentials at the metal surface can eradicate biofilms, and Mg and Mg-Ti particles have the same effect as cathodic potentials. Read More

View Article and Full-Text PDF

Area-Level Clustering of Shiga Toxin-Producing Infections and Their Socioeconomic and Demographic Factors in Ontario, Canada: An Ecological Study.

Foodborne Pathog Dis 2021 May 11. Epub 2021 May 11.

School of Public Health and Health Systems, University of Waterloo, Waterloo, Canada.

Shiga toxin-producing (STEC) infections are an important health burden for human populations in Ontario and worldwide. We assessed 452 STEC cases that were reported to Ontario's reportable disease surveillance system between 2015 and 2017. A retrospective scan statistic using a Poisson model was used to detect high-rate STEC clusters at the forward sortation area (FSA; the first three digits of a postal code) level. Read More

View Article and Full-Text PDF

Detection of Extended-Spectrum Beta-Lactamase-Producing and Carbapenem-Resistant Bacteria from Mink Feces and Feed in the United States.

Foodborne Pathog Dis 2021 May 11:1-10. Epub 2021 May 11.

Utah Water Research Laboratory, Department of Civil and Environmental Engineering, Utah State University, Logan, Utah, USA.

Antibiotic-resistant infections caused by extended-spectrum β-lactamases (ESBLs) and carbapenemases are increasing worldwide. Bacteria resistant to extended-spectrum cephalosporins and last resort carbapenems have been reported from food animals and their environments. Other concentrated nonfood-producing animals such as mink farming can be a reservoir of bacteria resistant to these critically important antibiotics. Read More

View Article and Full-Text PDF

Evaluation of a Commercial Broth Microdilution Panel for Colistin Susceptibility Testing of Clinical Isolates of Escherichia coli and Klebsiella pneumoniae.

Clin Lab 2021 May;67(5)

Background: Colistin is among the last resort antibiotics for the treatment of infections caused by multidrug-resistant Gram-negative pathogens. Antimicrobial susceptibility testing of colistin is challenging due to its physicochemical properties. Broth microdilution (BMD) is the recommended method for colistin susceptibility testing. Read More

View Article and Full-Text PDF

Proteomic and Transcriptomic Analysis of φX174 Infection Reveals Broad Upregulation of Host Escherichia coli Membrane Damage and Heat Shock Responses.

mSystems 2021 May 11;6(3). Epub 2021 May 11.

Department of Molecular Sciences, Macquarie University, Sydney, NSW, Australia

Measuring host-bacteriophage dynamics is an important approach to understanding bacterial survival functions and responses to infection. The model bacteriophage φX174 is endemic to the human gut and has been studied for over 70 years, but the host response to infection has never been investigated in detail. To address this gap in our understanding of this important interaction within our microbiome, we have measured host C proteomic and transcriptomic response to φX174 infection. Read More

View Article and Full-Text PDF

Three-Dimensional Micropatterning Deters Early Bacterial Adherence and Can Eliminate Colonization.

ACS Appl Mater Interfaces 2021 May 11. Epub 2021 May 11.

Department of Mechanical and Aerospace Engineering, Monash University, Clayton, Victoria 3800, Australia.

Developing strategies to prevent bacterial infections that do not rely on the use of drugs is regarded globally as an important means to stem the tide of antimicrobial resistance, as argued by the World Health Organization (WHO) (Mendelson, M.; Matsoso, M. P. Read More

View Article and Full-Text PDF

Mechanistic insights into synergy between nalidixic acid and tetracycline against clinical isolates of Acinetobacter baumannii and Escherichia coli.

Commun Biol 2021 May 10;4(1):542. Epub 2021 May 10.

Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, India.

The increasing prevalence of antimicrobial resistance has become a global health problem. Acinetobacter baumannii is an important nosocomial pathogen due to its capacity to persist in the hospital environment. It has a high mortality rate and few treatment options. Read More

View Article and Full-Text PDF

An infection-induced RhoB-Beclin 1-Hsp90 complex enhances clearance of uropathogenic Escherichia coli.

Nat Commun 2021 May 10;12(1):2587. Epub 2021 May 10.

Department of Immunology, Key Laboratory of Immune Microenvironment and Disease of the Educational Ministry of China, Tianjin Key Laboratory of Cellular and Molecular Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.

Host cells use several anti-bacterial pathways to defend against pathogens. Here, using a uropathogenic Escherichia coli (UPEC) infection model, we demonstrate that bacterial infection upregulates RhoB, which subsequently promotes intracellular bacteria clearance by inducing LC3 lipidation and autophagosome formation. RhoB binds with Beclin 1 through its residues at 118 to 140 and the Beclin 1 CCD domain, with RhoB Arg133 being the key binding residue. Read More

View Article and Full-Text PDF

Impact of the inclusion of an aminoglycoside to the initial empirical antibiotic therapy for Gram-negative bloodstream infections in hematological neutropenic patients: a propensity-matched cohort study (AMINOLACTAM study).

Antimicrob Agents Chemother 2021 May 10. Epub 2021 May 10.

Infectious Disease Department, Bellvitge University Hospital, Hospitalet del Llobregat, Barcelona, Spain.

To test the hypothesis that the addition of an aminoglycoside to a ß-lactam antibiotic could provide better outcomes than ß-lactam monotherapy for the initial empirical treatment of hematological neutropenic patients with subsequently documented Gram-negative bacilli (GNB) bloodstream infection (BSI). Multinational, retrospective, cohort study of GNB BSI episodes in hematological neutropenic patients in six centers (2010-2017). Combination therapy (ß-lactam plus aminoglycoside) was compared to ß-lactam monotherapy. Read More

View Article and Full-Text PDF

Detection of CTX-M-27 β-lactamase genes on two distinct plasmid types in ST38 from three US states.

Antimicrob Agents Chemother 2021 May 10. Epub 2021 May 10.

University of Rochester Medical Center, Clinical Microbiology, Department of Pathology and Laboratory Medicine, Rochester, NY

Infections caused by extended-spectrum β-lactamase (ESBL)-producing are a significant cause of morbidity and healthcare costs. Globally, the prevailing clonal type is ST131 in association with the blaCTX-M-15 β-lactamase gene. However, other ESBLs such as blaCTX-M-14 and blaCTX-M-27 can also be prevalent in some regions. Read More

View Article and Full-Text PDF

Escherichia coli urinary tract infections: Host age-related differences in bacterial virulence factors and antimicrobial susceptibility.

J Microbiol Immunol Infect 2021 Apr 29. Epub 2021 Apr 29.

Institute of Microbiology and Immunology, School of Life Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan. Electronic address:

Background: Urinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC) are one of the most common outpatient bacterial infections. Although bacterial and host factors are reported to be associated with UTI pathogenesis, little is known about the host age-related differences in bacterial virulence factors and antimicrobial susceptibility.

Methods: PCRs were carried out to detect K1 capsule antigen, 15 virulence factors, and phylogenetic groups in E. Read More

View Article and Full-Text PDF

Antimicrobial susceptibility testing results from 13 hospitals in Viet Nam: VINARES 2016-2017.

Antimicrob Resist Infect Control 2021 May 10;10(1):78. Epub 2021 May 10.

Oxford University Clinical Research Unit, National Hospital for Tropical Diseases, 78 Giai Phong, Dong Da, Hanoi, Viet Nam.

Objective: To analyse data from 2016-17 from a hospital-based antimicrobial resistance surveillance with national coverage in a network of hospitals Viet Nam.

Methods: We analysed data from 13 hospitals, 3 less than the dataset from the 2012-13 period. Identification and antimicrobial susceptibility testing data from the clinical microbiology laboratories from samples sent in for routine diagnostics were used. Read More

View Article and Full-Text PDF

Bacterial profile and antimicrobial susceptibility patterns of isolates among patients diagnosed with surgical site infection at a tertiary teaching hospital in Ethiopia: a prospective cohort study.

Ann Clin Microbiol Antimicrob 2021 May 10;20(1):33. Epub 2021 May 10.

Department of Clinical Pharmacy, School of Pharmacy, Institute of Health, Jimma University, Jimma, Ethiopia.

Background: Globally, surgical site infections are the most reported healthcare-associated infection and common surgical complication. In developing countries such as Ethiopia, there is a paucity of published reports on the microbiologic profile and resistance patterns of an isolates.

Objective: This study aimed at assessing the bacterial profile and antimicrobial susceptibility patterns of isolates among patients diagnosed with surgical site infection at Jimma Medical Center in Ethiopia. Read More

View Article and Full-Text PDF

Risk Factor Analysis of Children's Exposure to Microbial Pathogens in Playgrounds.

Risk Anal 2021 May 9. Epub 2021 May 9.

Department of Public Health, School of Medicine, University of Patras, Patras, Greece.

Bacteria are commonly found in soil and may cause health risks to children playing in the outdoor playgrounds with soil, mainly via hand to mouth and pica behaviors. Our study concerned with the risk analysis of infection of a child playing in urban playgrounds in the cities of Patras and Pyrgos in Greece. The presence of Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa were analyzed in soil samples of these playgrounds. Read More

View Article and Full-Text PDF

Co-infection of H9N2 Influenza A Virus and in a BALB/c Mouse Model Aggravates Lung Injury by Synergistic Effects.

Front Microbiol 2021 21;12:670688. Epub 2021 Apr 21.

Key Laboratory of Fujian-Taiwan Animal Pathogen Biology, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou, China.

Pathogens that cause respiratory diseases in poultry are highly diversified, and co-infections with multiple pathogens are prevalent. The H9N2 strain of avian influenza virus (AIV) and () are common poultry pathogens that limit the development of the poultry industry. This study aimed to clarify the interaction between these two pathogens and their pathogenic mechanism using a mouse model. Read More

View Article and Full-Text PDF

Overexpression of Toll-like receptor 4 contributes to the internalization and elimination of Escherichia coli in sheep by enhancing caveolae-dependent endocytosis.

J Anim Sci Biotechnol 2021 May 10;12(1):63. Epub 2021 May 10.

Beijing Key Laboratory for Animal Genetic Improvement, National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics and Breeding of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing, China.

Background: Gram-negative bacterial infections have a major economic impact on both the livestock industry and public health. Toll-like receptor 4 (TLR4) plays a crucial role in host defence against Gram-negative bacteria. Exploring the defence mechanism regulated by TLR4 may provide new targets for treatment of inflammation and control of bacterial infections. Read More

View Article and Full-Text PDF

A Study of the Chemistries, Growth Mechanisms, and Antibacterial Properties of Cerium- and Yttrium-Containing Nanoparticles.

ACS Biomater Sci Eng 2021 May 23;7(5):1787-1807. Epub 2020 Sep 23.

Department of Chemical Engineering, Northeastern University, Boston Massachusetts 02115, United States.

Under the current climate, physicians prescribe antibiotics for treating bacterial infections, and such a limitation to a single class of drugs is disadvantageous since antibiotic-resistant bacteria have adapted to withstanding their stresses. Antibiotic alternatives are sought, and herein metal nanoparticles comprised of the rare earth elements cerium and yttrium were determined to invoke toxicity on methicillin-resistant (MRSA) and a multi-drug-resistant strain of (MDR ). Ceria nanoparticles, yttrium-doped ceria nanoparticles, and cerium-doped yttria nanoparticles were fabricated by a wet chemical route, homogeneous precipitation in hexamethylenetetramine (HMT). Read More

View Article and Full-Text PDF

Hormetic dose-responses for silver antibacterial compounds, quorum sensing inhibitors, and their binary mixtures on bacterial resistance of Escherichia coli.

Sci Total Environ 2021 May 1;786:147464. Epub 2021 May 1.

State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China; Shanghai Key Lab of Chemical Assessment and Sustainability, Shanghai, China; Post-doctoral Research Station, College of Civil Engineering, Tongji University, Shanghai 200092, China. Electronic address:

Silver antibacterial compounds (SACs) and quorum sensing inhibitors (QSIs), as the potential antibiotic substitutes, have been recommended to prevent and treat microbial infections for the purpose of controlling the increasingly serious bacterial resistance induced by the abuse of antibiotics. However, there is little information regarding the resistance risk of these compounds, especially their mixtures. In this study, bacterial mutation and RP4 plasmid conjugative transfer among bacteria were used to characterize the bacterial endogenous and exogenous resistance, respectively. Read More

View Article and Full-Text PDF

Enterotoxigenic Escherichia coli (ETEC) vaccines: Priority activities to enable product development, licensure, and global access.

Vaccine 2021 May 6. Epub 2021 May 6.


Diarrhoeal disease attributable to enterotoxigenic Escherichia coli (ETEC) causes substantial morbidity and mortality predominantly in paediatric populations in low- and middle-income countries. In addition to acute illness, there is an increasing appreciation of the long-term consequences of enteric infections, including ETEC, on childhood growth and development. Provision of potable water and sanitation and appropriate clinical care for acute illness are critical to reduce the ETEC burden. Read More

View Article and Full-Text PDF

Hierarchically hybrid biocoatings on Ti implants for enhanced antibacterial activity and osteogenesis.

Colloids Surf B Biointerfaces 2021 Apr 29;204:111802. Epub 2021 Apr 29.

Department of Orthodontics, The Affiliated Hospital of Qingdao University, Qingdao, 266003, China; School of Stomatology, Qingdao University, Qingdao, 266003, China; Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266021, China. Electronic address:

Titanium (Ti) is widely applied as bone-anchoring implants in dental and orthopedic applications owing to its superior mechanical characteristics, high corrosion resistance, and excellent biocompatibility. Nevertheless, Ti-based implants with the deficiencies of insufficient osteoinduction and associated infections can result in implant failure, which significantly limits its applications in some cases. In this work, hierarchically hybrid biocoatings on Ti implants are developed by gradual incorporation of polydopamine (PDA), ZnO nanoparticles (nZnO), and chitosan (CS)/nanocrystal hydroxyapatite (nHA) via oxidative self-polymerization, nanoparticle deposition, solvent casting and evaporation methods for enhancing their antibacterial activity and osteogenesis. Read More

View Article and Full-Text PDF

Molecular characterization of ESBL- producing uropathogenic Escherichia coli recovered from urine samples of patients attending a University Teaching hospital in Nigeria.

Acta Microbiol Immunol Hung 2021 May 7. Epub 2021 May 7.

3Microbial Physiology and Biochemistry Laboratory, Department of Microbiology, University of Ibadan, Nigeria.

Infection of the urinary tract ranks as one of the most common infections affecting people worldwide and its treatment is made complicated by the rising incidence of antibiotic resistance. This study aimed to detect extended spectrum beta-lactamase (ESBL) genes and antibiotic resistance profile of uropathogenic Escherichia coli (E. coli) recovered from patients attending a University Teaching hospital in Nigeria. Read More

View Article and Full-Text PDF

strains producing selected bacteriocins inhibit porcine enterotoxigenic (ETEC) both under and conditions.

Appl Environ Microbiol 2021 May 7. Epub 2021 May 7.

Department of Biology, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic

Enterotoxigenic (ETEC) and Shiga toxin-producing (STEC) strains are the causative agents of severe foodborne diseases in both humans and animals. In this study, porcine pathogenic strains (n = 277) as well as porcine commensal strains (n = 188) were tested for their susceptibility to 34 bacteriocin monoproducers to identify the most suitable bacteriocin types inhibiting porcine pathogens. Under condition, the set of pathogenic was found to be significantly more susceptible to a majority of tested bacteriocins when compared to commensal Based on production of bacteriocins with specific activity against pathogen, three potentially probiotic commensal strains of human origin were selected. Read More

View Article and Full-Text PDF

Titanium carbide/zeolite imidazole framework-8/polylactic acid electrospun membrane for near-infrared regulated photothermal/photodynamic therapy of drug-resistant bacterial infections.

J Colloid Interface Sci 2021 Apr 24;599:390-403. Epub 2021 Apr 24.

State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, Dalian, Liaoning 116024, PR China. Electronic address:

Bacteria induced wound infection has become fatal healthcare issues needed to be resolved urgently. It is of vital importance to develop multifunctional therapeutic platforms to fight against increased bacterial antibiotic resistance. Herein, a titanium carbide (MXene)/zeolite imidazole framework-8 (ZIF-8)/polylactic acid (PLA) composite membrane (MZ-8/PLA) was fabricated through in-situ growth of ZIF-8 on MXene and the subsequent electrospinning process. Read More

View Article and Full-Text PDF

Characterization of Blue Light Treatment for Infected Wounds: Antibacterial Efficacy of 420, 455, and 480 nm Light-Emitting Diode Arrays Against Common Skin Pathogens Versus Blue Light-Induced Skin Cell Toxicity.

Photobiomodul Photomed Laser Surg 2021 May;39(5):339-348

Chair, Department of Virology and Microbiology, Centre for Biomedical Education and Research (ZBAF), University Witten/Herdecke, Witten, Germany.

To determine effective treatment strategies against bacterial infections of chronic wounds, we tested different blue light (BL)-emitting light-emitting diode arrays (420, 455, and 480 nm) against wound pathogens and investigated in parallel BL-induced toxic effects on human dermal fibroblasts. Wound infection is a major factor for delayed healing. Infections with and are clinically relevant caused by their ability of biofilm formation and their quickly growing antibiotics resistance. Read More

View Article and Full-Text PDF

Antimicrobial susceptibility of bacterial isolates from urinary tract infections in companion animals in Spain.

Vet Rec 2021 May 28;188(9):e60. Epub 2021 Jan 28.

Catalan Wildlife Service, Centre de Fauna Salvatge de Torreferrussa, Barcelona, Spain.

Background: The increasing emergence of multidrug-resistant bacteria, causing urinary tract infections (UTI) in dogs and cats, represents a great therapeutic challenge and a public health concern.

Methods: Laboratory records of 4943 urinary microbiological diagnosis results and antimicrobial resistance profiles of suspected UTI cases in dogs and cats were analysed from 2016 to 2018 in Spain.

Results: This study showed a higher percentage of positive microbiological diagnoses in dogs (42%, 1368/3270) than in cats (27%, 457/1673). Read More

View Article and Full-Text PDF

Evaluation of Clinical Characteristics and Outcomes of Postoperative Infections in Living Liver Donors.

Int J Clin Pract 2021 May 6:e14324. Epub 2021 May 6.

Department of Infectious Diseases and Clinical Microbiology, Inonu University Faculty of Medicine, 44280, Malatya, Turkey.

Aim: To analyze developing infections after living donor hepatectomy (LDH) in living liver donors (LLDs).

Methods: Demographic and clinical charecteristics of 1106 LLDs were retrospectively analysed in terms of whether postoperative infection development. Therefore, LLDs were divided into two group: with (n=190) and without (n=916) antimicrobial agent use. Read More

View Article and Full-Text PDF