53,741 results match your criteria Escherichia Coli Infections


Emerging Infectious Diseases and Antimicrobial Resistance (EIDAR).

Mil Med 2019 Apr 20. Epub 2019 Apr 20.

University of Nebraska Medical Center College of Public Health, 984355 Medical Center, Omaha, NB 68198.

Introduction: The Infectious Disease Clinical Research Program's (IDCRP) Emerging Infectious Diseases and Antimicrobial Resistance (EIDAR) Research Area is a Department of Defense (DoD) clinical research capability that is responsive and adaptive to emerging infectious disease (EID) threats to US military readiness. Among active-duty and other Military Health System (MHS) beneficiaries, EIDAR research is largely focused on evaluating the incidence, risk factors, and acute- and long-term health effects of military-relevant EIDs, especially those caused by high-consequence pathogens or are responsible for outbreaks among US military populations. The EIDAR efforts also address Force Health Protection concerns associated with antimicrobial resistance and antimicrobial stewardship practices within the MHS. Read More

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https://academic.oup.com/milmed/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/milmed/usz081DOI Listing
April 2019
1 Read

Efflux pump inhibitors of clinically relevant multidrug resistant bacteria.

Med Res Rev 2019 Apr 19. Epub 2019 Apr 19.

Chair of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.

Bacterial infections are an increasingly serious issue worldwide. The inability of existing therapies to treat multidrug-resistant pathogens has been recognized as an important challenge of the 21st century. Efflux pumps are important in both intrinsic and acquired bacterial resistance and identification of small molecule efflux pump inhibitors (EPIs), capable of restoring the effectiveness of available antibiotics, is an active research field. Read More

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http://dx.doi.org/10.1002/med.21591DOI Listing

Alarmone Ap4A is elevated by aminoglycoside antibiotics and enhances their bactericidal activity.

Proc Natl Acad Sci U S A 2019 Apr 19. Epub 2019 Apr 19.

Faculty of Health Sciences, University of Macau, Macau SAR, China;

Second messenger molecules play important roles in the responses to various stimuli that can determine a cell's fate under stress conditions. Here, we report that lethal concentrations of aminoglycoside antibiotics result in the production of a dinucleotide alarmone metabolite-diadenosine tetraphosphate (Ap4A), which promotes bacterial cell killing by this class of antibiotics. We show that the treatment of with lethal concentrations of kanamycin (Kan) dramatically increases the production of Ap4A. Read More

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http://dx.doi.org/10.1073/pnas.1822026116DOI Listing
April 2019
2 Reads

A comparative analysis of infection in patients with malignant cancer: A clinical pharmacist consultation study.

J Infect Public Health 2019 Apr 17. Epub 2019 Apr 17.

Department of Oncology, Peking University International Hospital, Beijing 102206, China. Electronic address:

Background: Infection analysisamongst malignant cancer patients remains elusive. The objective of this study is to investigate the characteristics of both infection and anti-infection treatments in patients group with malignant cancer.

Methods: We retrospectively studied the clinical data of 148 patients with malignant cancer and 171 benign patients enrolled in the pharmacist consultation from April 2015 to April 2017. Read More

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http://dx.doi.org/10.1016/j.jiph.2019.03.021DOI Listing

The use of aminoglycosides in animals within the EU: development of resistance in animals and possible impact on human and animal health: a review.

J Antimicrob Chemother 2019 Apr 19. Epub 2019 Apr 19.

Veterinary Medicines Directorate, Addlestone, UK.

Aminoglycosides (AGs) are important antibacterial agents for the treatment of various infections in humans and animals. Following extensive use of AGs in humans, food-producing animals and companion animals, acquired resistance among human and animal pathogens and commensal bacteria has emerged. Acquired resistance occurs through several mechanisms, but enzymatic inactivation of AGs is the most common one. Read More

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http://dx.doi.org/10.1093/jac/dkz161DOI Listing

McbR is involved in biofilm formation and H2O2 stress response in avian pathogenic Escherichia coli X40.

Poult Sci 2019 Apr 19. Epub 2019 Apr 19.

School of Life Sciences, Anhui Agricultural University, Hefei, Anhui 230036, China.

Avian pathogenic Escherichia coli (APEC) causes a variety of extraintestinal diseases known as colibacillosis and is responsible for significant economic losses in the poultry industry worldwide. Biofilm formation results in increased morbidity and persistent infections, and is the main reason for the difficult treatment of colibacillosis with antimicrobial agents. It is reported that the transcriptional regulator McbR regulates biofilm formation and mucoidy by repressing the expression of the periplasmic protein YbiM, and activates the transcription of the yciGFE operon by binding to the yciG promoter in E. Read More

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http://dx.doi.org/10.3382/ps/pez205DOI Listing

Clinical isolates of Escherichia coli are resistant both to antibiotics and organotin compounds.

Folia Microbiol (Praha) 2019 Apr 17. Epub 2019 Apr 17.

Faculty for Higher Education Zaragoza, UNAM, Mexico City, Mexico.

Antibiotic-resistant Escherichia coli are common causative agents of human urinary tract infections. Organotin compounds (OTCs) are man-made chemicals that may affect the renal function of exposed humans and rodents. OTCs are widely recognized as bactericides. Read More

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http://link.springer.com/10.1007/s12223-019-00707-1
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http://dx.doi.org/10.1007/s12223-019-00707-1DOI Listing
April 2019
1 Read

The Effect of Recombinant Human Erythropoietin on Bacterial Growth: A Dual-Edged Sword.

Kidney Dis (Basel) 2019 Mar 13;5(2):81-90. Epub 2018 Nov 13.

Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Background: Hypererythropoietinemia is associated with common diseases like non-uremic anaemia where infection burden is high. Erythropoietin (EPO) is also given as therapy for anaemia associated with chronic kidney disease and cancer and in those who are at a higher risk of infections. EPO is known to have an effect on macrophages by which it helps in the growth of some intracellular pathogens. Read More

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https://www.karger.com/Article/FullText/493684
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http://dx.doi.org/10.1159/000493684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468308PMC
March 2019
3 Reads

Fecal Colonization With Multidrug-Resistant Among Healthy Infants in Rural Bangladesh.

Front Microbiol 2019 2;10:640. Epub 2019 Apr 2.

Eawag, Swiss Federal Institute of Aquatic Science and Technology, Dübendorf, Switzerland.

Third generation cephalosporins (3GC) are one of the main choices for treatment of infections caused by multidrug-resistant (MDR) Gram-negative bacteria. Due to their overuse, an increasing trend of resistance to 3GC has been observed in developing countries. Here, we describe fecal colonization of 3GC-resistant (3GCr) in healthy infants (1-12 months old) living in rural areas of Bangladesh. Read More

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https://www.frontiersin.org/article/10.3389/fmicb.2019.00640
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http://dx.doi.org/10.3389/fmicb.2019.00640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454046PMC
April 2019
1 Read

Prevalence of health care-associated infections and antimicrobial resistance of the responsible pathogens in Ukraine: Results of a multicenter study (2014-2016).

Am J Infect Control 2019 Apr 15. Epub 2019 Apr 15.

Department of Anatomy, Topographical Anatomy, and Operative Surgery, Private Higher Educational Establishment "Kyiv Medical University," Kyiv, Ukraine.

Background: The aim of this study was to obtain the first national estimates of the current prevalence and incidence and death of health care-associated infections (HAIs) of all types in acute care hospitals in Ukraine.

Methods: Prospective surveillance was conducted from January 2014 to December 2016 in 17 hospitals. Surveillance case definitions were derived from the Centers for Disease Control and Prevention's National Healthcare Safety Network HAI case definitions. Read More

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http://dx.doi.org/10.1016/j.ajic.2019.03.007DOI Listing

Rapid screening of engineered microbial therapies in a 3D multicellular model.

Proc Natl Acad Sci U S A 2019 Apr 17. Epub 2019 Apr 17.

Department of Biomedical Engineering, Columbia University, New York, NY 10027;

Synthetic biology is transforming therapeutic paradigms by engineering living cells and microbes to intelligently sense and respond to diseases including inflammation, infections, metabolic disorders, and cancer. However, the ability to rapidly engineer new therapies far outpaces the throughput of animal-based testing regimes, creating a major bottleneck for clinical translation. In vitro approaches to address this challenge have been limited in scalability and broad applicability. Read More

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http://dx.doi.org/10.1073/pnas.1820824116DOI Listing
April 2019
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Phenotypic and Genotypic characterization of ESBLs, AmpC and Carbapenemase-Producing Klebsiella pneumoniae and Escherichia coli Isolates.

Med Princ Pract 2019 Apr 16. Epub 2019 Apr 16.

Objectives: Drug resistance among gram-negative bacteria is a worldwide challenge. Due to the importance of drug-resistant Klebsiella pneumoniae and Escherichia coli strains in hospital-acquired infections, we aimed to determine the phenotypic and genotypic characteristics of ESBLs, AmpC and Carbapenemase-producing isolates, obtained from hospitalized patients in Tehran and Ilam, Iran.

Materials And Methods: In total, 90 isolates of K. Read More

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http://dx.doi.org/10.1159/000500311DOI Listing

The epidemiology of Shiga toxin-producing Escherichia coli infections in the South East of England: November 2013-March 2017 and significance for clinical and public health.

J Med Microbiol 2019 Apr 17. Epub 2019 Apr 17.

4 Field Services, National Infection Service, Public Health England, London, UK.

Purpose: This study describes the epidemiology of Shiga toxin-producing Escherichia coli (STEC) infections in a population in the South East of England.

Methods: From 1 November 2013 to 31 March 2017 participating diagnostic laboratories reported Shiga toxin gene (stx) positive real-time PCR results to local public health teams. Stx positive faecal samples/isolates were referred to the Gastrointestinal Bacteria Reference Unit (GBRU) for confirmation by culture and typing by whole genome sequencing (WGS). Read More

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https://www.microbiologyresearch.org/content/journal/jmm/10.
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http://dx.doi.org/10.1099/jmm.0.000970DOI Listing
April 2019
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Exposure of ciprofloxacin-resistant Escherichia coli broiler isolates to subinhibitory concentrations of a quaternary ammonium compound does not increase antibiotic resistance gene transfer.

Poult Sci 2019 Apr 16. Epub 2019 Apr 16.

Flanders Research Institute for Agriculture, Fisheries and Food (ILVO), Technology and Food Science Unit, Brusselsesteenweg 370, 9090 Melle, Belgium.

Resistance to antibiotics threatens to become a worldwide health problem. An important attributing phenomenon in this context is that pathogens can acquire antibiotic resistance genes through conjugative transfer of plasmids. To prevent bacterial infections in agricultural settings, the use of veterinary hygiene products, such as disinfectants, has gained popularity and questions have been raised about their contribution to such spreading of antibiotic resistance. Read More

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http://dx.doi.org/10.3382/ps/pez185DOI Listing

Cystic Fibrosis Rapid Response: Translating Multi-omics Data into Clinically Relevant Information.

MBio 2019 Apr 16;10(2). Epub 2019 Apr 16.

Department of Biology, San Diego State University, San Diego, California, USA

Pulmonary exacerbations are the leading cause of death in cystic fibrosis (CF) patients. To track microbial dynamics during acute exacerbations, a CF rapid response (CFRR) strategy was developed. The CFRR relies on viromics, metagenomics, metatranscriptomics, and metabolomics data to rapidly monitor active members of the viral and microbial community during acute CF exacerbations. Read More

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http://mbio.asm.org/lookup/doi/10.1128/mBio.00431-19
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http://dx.doi.org/10.1128/mBio.00431-19DOI Listing
April 2019
2 Reads

Uro-Vaxom® versus placebo for the prevention of recurrent symptomatic urinary tract infections in participants with chronic neurogenic bladder dysfunction: a randomised controlled feasibility study.

Trials 2019 Apr 16;20(1):223. Epub 2019 Apr 16.

National Spinal Injuries Centre, Stoke Mandeville Hospital, Buckinghamshire Healthcare NHS Trust, Aylesbury, HP21 8AL, UK.

Background: Patients with lower neurogenic bladder dysfunction are at an increased risk of suffering from recurrent urinary tract infections. Recurrent symptomatic urinary tract infection is occasionally treated with antibiotics as a prophylactic prevention strategy. This risks increasing the frequency of antibiotic resistance. Read More

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https://trialsjournal.biomedcentral.com/articles/10.1186/s13
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http://dx.doi.org/10.1186/s13063-019-3275-xDOI Listing
April 2019
2 Reads

Integrons and antibiotic resistance genes in water-borne pathogens: threat detection and risk assessment.

J Med Microbiol 2019 Apr 16. Epub 2019 Apr 16.

1 Medical Microbiology and Bioprocess Technology Laboratory, Department of Microbiology, Maharshi Dayanand University, Rohtak, Haryana 124001, India.

Antibiotic-resistant genes (ARGs) are regarded as emerging environmental pollutants and pose a serious health risk to the human population. Integrons are genetic elements that are involved in the spread of ARGs amongst bacterial species. They also act as reservoirs of these resistance traits, further contributing to the development of multi-drug resistance in several water-borne pathogens. Read More

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http://dx.doi.org/10.1099/jmm.0.000972DOI Listing

Coenzyme Q biosynthesis in the biopesticide Shenqinmycin-producing Pseudomonas aeruginosa strain M18.

J Ind Microbiol Biotechnol 2019 Apr 12. Epub 2019 Apr 12.

State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China.

Coenzyme Q (ubiquinone) is a redox-active isoprenylated benzoquinone commonly found in living organisms. The biosynthetic pathway for this lipid has been extensively studied in Escherichia coli and Saccharomyces cerevisiae; however, little is known in Pseudomonas aeruginosa. In this study, we observed that CoQ is the predominant coenzyme Q synthesized by the Shenqinmycin-producing strain M18. Read More

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http://link.springer.com/10.1007/s10295-019-02179-1
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http://dx.doi.org/10.1007/s10295-019-02179-1DOI Listing
April 2019
2 Reads

Selective and suppressive effects of antibiotics on donor and recipient bacterial strains in gut microbiota determine transmission efficiency of blaNDM-1-bearing plasmids.

J Antimicrob Chemother 2019 Apr 15. Epub 2019 Apr 15.

Shenzhen Key Laboratory for Food Biological Safety Control, Food Safety and Technology Research Centre, The Hong Kong PolyU Shenzhen Research Institute, Shenzhen, P. R. China.

Objectives: To test whether antibiotics of different functional categories exhibit differential potential in promoting transmission of MDR-encoding plasmids among members of the gut microbiome.

Methods: Rats inoculated with blaNDM-1-bearing Klebsiella pneumoniae were subjected to treatment with different types of antibiotics. The structural changes in the gastrointestinal (GI) tract microbiome were determined by 16S rRNA sequencing and analysis. Read More

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http://dx.doi.org/10.1093/jac/dkz137DOI Listing

Nosocomial infections in surgical intensive care unit: A retrospective single-center study.

Int J Crit Illn Inj Sci 2019 Jan-Mar;9(1):16-20

Department of Anaesthesiology and Critical Care, Smt. Kashibai Navale Medical College, Pune, Maharashtra, India.

Aims: This study aims to study the incidence, microbiological and antibiotic sensitivity and resistance profile and impact on intensive care units (ICUs) stay and mortality of nosocomial infections in patients admitted to surgical ICU of our hospital.

Methods: A retrospective analysis of all patients admitted, over the course of 1 year, in the surgical ICU was undertaken. All patients who developed nosocomial infections were included in the study. Read More

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http://www.ijciis.org/text.asp?2019/9/1/16/253764
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http://dx.doi.org/10.4103/IJCIIS.IJCIIS_57_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423928PMC
April 2019
3 Reads

Azithromycin resistance levels and mechanisms in Escherichia coli.

Sci Rep 2019 Apr 15;9(1):6089. Epub 2019 Apr 15.

ISGlobal, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.

Despite azithromycin being used in some countries to treat infections caused by Gram-negative pathogens, no resistance breakpoint for Escherichia coli exists. The aim of this study was to analyse the levels and mechanisms of azithromycin resistance in E. coli. Read More

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http://www.nature.com/articles/s41598-019-42423-3
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http://dx.doi.org/10.1038/s41598-019-42423-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465286PMC
April 2019
2 Reads

In vitro activity of cefepime-enmetazobactam against Gram-negative isolates collected from United States and European hospitals during 2014-2015.

Antimicrob Agents Chemother 2019 Apr 15. Epub 2019 Apr 15.

Allecra Therapeutics SAS, St-Louis, France

Enmetazobactam, formerly AAI101, is a novel penicillanic acid sulfone extended-spectrum β-lactamase inhibitor. The combination of enmetazobactam with cefepime has entered clinical trials to assess safety and efficacy in patients with complicated urinary tract infections. Here, the in vitro activity of cefepime-enmetazobactam was determined for 1,993 clinical isolates of Enterobacteriaceae and collected in the US and Europe during 2014 and 2015. Read More

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http://dx.doi.org/10.1128/AAC.00514-19DOI Listing

Synergistic effect of colistin combined with PFK-158 against colistin-resistant Enterobacteriaceae.

Antimicrob Agents Chemother 2019 Apr 15. Epub 2019 Apr 15.

Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

As increasing numbers of colistin-resistant bacteria emerge, new therapies are urgently needed to treat infections caused by these pathogens. The discovery of new combination therapies is one important way to solve such problems. Herein, we report that the antitumor drug PFK-158 and its analogs PFK-015 and 3PO can exert synergistic effects with colistin against colistin-resistant Enterobacteriaceae, including positive or high-level colistin resistant (HLCR) isolates, as shown by a checkerboard assay. Read More

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http://dx.doi.org/10.1128/AAC.00271-19DOI Listing

Most domestic livestock possess colistin-resistant commensal harboring in a rural community in Vietnam.

Antimicrob Agents Chemother 2019 Apr 15. Epub 2019 Apr 15.

Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan

Colistin is recognized as the last resort for treatment of life-threatening infections caused by multidrug-resistant bacteria; however, the increasing prevalence of colistin-resistant bacteria harboring the mobile colistin resistance gene () poses a threat to the treatment (1).…. Read More

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http://dx.doi.org/10.1128/AAC.00594-19DOI Listing

Novel Mutation in GALT Gene in Galactosemia Patient with Group B Streptococcus Meningitis and Acute Liver Failure.

Medicina (Kaunas) 2019 Apr 4;55(4). Epub 2019 Apr 4.

Second Pediatric Clinic, Department of Mother and Child, University of Medicine and Pharmacy "Iuliu Hațieganu" Cluj-Napoca, 400012 Cluj-Napoca, Romania.

Classic galactosemia is an autosomal recessive disorder caused by the deficiency of the enzyme galactose-1-phosphate uridyltransferase (GALT) involved in galactose metabolism. Bacterial infections are a known cause of early morbidity and mortality in children with classic galactosemia. The most common agent is but in rare situations, other bacteria are incriminated. Read More

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http://dx.doi.org/10.3390/medicina55040091DOI Listing
April 2019
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A Sample Preparation Technique Using Biocompatible Composites for Biomedical Applications.

Molecules 2019 Apr 3;24(7). Epub 2019 Apr 3.

Department of Convergence Medicine, Asan Medical Institute of Convergence Science and Technology (AMIST), University of Ulsan College of Medicine, 88 Olympicro-43gil, Songpa-gu, Seoul 05505, Korea.

Infectious diseases, especially pathogenic infections, are a growing threat to public health worldwide. Since pathogenic bacteria usually exist in complex matrices at very low concentrations, the development of technology for rapid, convenient, and biocompatible sample enrichment is essential for sensitive diagnostics. In this study, a cucurbit[6]uril (CB) supermolecular decorated amine-functionalized diatom (DA) composite was fabricated to support efficient sample enrichment and in situ nucleic acid preparation from enriched pathogens and cells. Read More

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https://www.mdpi.com/1420-3049/24/7/1321
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http://dx.doi.org/10.3390/molecules24071321DOI Listing
April 2019
1 Read

High prevalence of extended-spectrum beta-lactamase-producing Gram-negative pathogens from patients attending Felege Hiwot Comprehensive Specialized Hospital, Bahir Dar, Amhara region.

PLoS One 2019 15;14(4):e0215177. Epub 2019 Apr 15.

Department of Medical Microbiology, School of Biomedical and laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Background: Infections caused by extended-spectrum beta-lactamases (ESBL) producing Gram-negative bacteria has emerge as a global threat in clinical practices. The treat is more serious in developing countries due to inappropriate use, poor adherence, use of counterfeit, sub-standard antibiotics and poor infection control practices. Data on ESBL producing Gram-negative bacteria are limited in developing countries including Ethiopia. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215177PLOS
April 2019
3.234 Impact Factor

Uropathogens and their antimicrobial resistance patterns: Relationship with urinary tract infections.

Int J Health Sci (Qassim) 2019 Mar-Apr;13(2):48-55

Department of Pathology and Laboratory Medicine, College of Medicine, Qassim University, Saudi Arabia.

Objectives: This study was performed to determine the prevalence of uropathogens causing urinary tract infections (UTIs) and to determine their pattern of antimicrobial resistance.

Methods: This study was conducted on 273 urine samples collected from outpatient departments (OPDs) of Qassim University affiliated hospitals. Fully automated VITEK 2 compact system was used in the identification and antimicrobial susceptibility testing of causative microorganisms. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436442PMC

Detection of biofilm among uropathogenic and its correlation with antibiotic resistance pattern.

J Lab Physicians 2019 Jan-Mar;11(1):17-22

Department of Microbiology, BLDE (Deemed to be University) Shri B M Patil Medical College, Vijayapura, Karnataka, India.

Background: accounts for 70%-95% of urinary tract infections (UTIs). UTI is a serious health problem with respect to antibiotic resistance and biofilms formation being the prime cause for the antibiotic resistance. Biofilm can restrict the diffusion of substances and binding of antimicrobials. Read More

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http://www.jlponline.org/text.asp?2019/11/1/17/254089
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http://dx.doi.org/10.4103/JLP.JLP_98_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437818PMC
April 2019
1 Read

High antibacterial activity of chitosan - molybdenum disulfide nanocomposite.

Carbohydr Polym 2019 Jul 26;215:226-234. Epub 2019 Mar 26.

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, PR China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, PR China. Electronic address:

Bacterial infections have evolved as a life-threatening problem afflicting people due to the abuse of antibiotics and emergence of drug-resistant bacteria. Thus developing novel antibacterial materials is an urgent need. Herein, chitosan-MoS (CS-MoS) nanocomposite was synthesized through thiol ligand functionalization and chemical modification to achieve more efficient bactericidal activity. Read More

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http://dx.doi.org/10.1016/j.carbpol.2019.03.085DOI Listing

1,4-Naphthoquinone Analogues: Potent Antibacterial Agents and Mode of Action Evaluation.

Molecules 2019 Apr 11;24(7). Epub 2019 Apr 11.

Department of Life Science, Department of Energy Storage/Conversion Engineering of Graduate School, and Hydrogen and Fuel Cell Research Center, Chonbuk National University, Jeollabuk-do 54896, Korea.

1,4-Naphthoquinones have antibacterial activity and are a promising new class of compound that can be used to treat bacterial infections. The goal was to improve effective antibacterial agents; therefore, we synthesized a new class of naphthoquinone hybrids, which contain phenylamino-phenylthio moieties as significant counterparts. Compound was modified as a substituted aryl amide moiety, which enhanced the antibacterial activity of earlier compounds and . Read More

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https://www.mdpi.com/1420-3049/24/7/1437
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http://dx.doi.org/10.3390/molecules24071437DOI Listing
April 2019
1 Read

In-vitro phagocytosis and intracellular killing of Pasteurella multocida B:2 by phagocytic cells of buffaloes.

Microb Pathog 2019 Apr 10;131:170-174. Epub 2019 Apr 10.

Research Centre for Ruminant Diseases, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400, Serdang, Malaysia.

Pasteurella multocida B:2 is a Gram-negative organism causing haemorrhagic septicaemia (HS) in buffaloes. It causes severe pulmonary infection, leading to infiltration of numerous macrophages and neutrophils. Despite the inflammatory response, buffaloes succumb to HS. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.04.012DOI Listing

Epidemiological and clinical features of prosthetic joint infections caused by gram-negative bacteria.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):187-194

Fondazione Policlinico A. Gemelli IRCCS - Rome, Italy.

Objective: To review the clinical literature focusing on epidemiology, clinical presentation and outcomes of prosthetic joint infections (PJIs) due to gram-negative bacteria (GNB) and to report the experience of a multicentric cohort.

Patients And Methods: A retrospective, observational, cohort study was performed in three Italian hospitals. All consecutive PJIs caused by GNB over a 12-year period (from May 2007 to March 2018) were enrolled. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17490DOI Listing

Do liquid wastes from automated instruments in medical laboratories have their proper microbicide effect?

Ann Biol Clin (Paris) 2019 Apr 12. Epub 2019 Apr 12.

Laboratoire de virologie, Institut des agents infectieux, Groupement Hospitalier Nord des Hospices civils de Lyon, Lyon, France, Institut des sciences biologiques et pharmaceutiques de Lyon, Université Claude Bernard Lyon 1, Lyon, France, CIRI, Centre international de recherche en infectiologie, Équipe Virpath, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École normale supérieure de Lyon, Lyon, France.

Liquid wastes from clinical biology automated systems are currently evacuated in the urban network after chemical treatment to eliminate a possible risk of infection. Since these wastes are ecotoxic because of the presence of numerous chemical reagents, we studied their intrinsic microbicidal power towards a selection of infectious agents widely found in clinical specimens. The objective was to determine if an additional anti-infectious treatment before elimination is necessary. Read More

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http://dx.doi.org/10.1684/abc.2019.1431DOI Listing
April 2019
1 Read

Clinical Prediction Score for Community-Onset Bloodstream Infections Caused by Extended-Spectrum Beta-Lactamase-Producing and Species.

J Korean Med Sci 2019 Apr 15;34(14):e116. Epub 2019 Apr 15.

Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.

Background: This study aimed to identify the predictors and build a prediction score for community-onset bloodstream infections (CO-BSIs) caused by extended-spectrum beta-lactamase (ESBL)-producing and species.

Methods: All CO-BSIs caused by and species from 2012 to 2015 were grouped into derivation (BSIs from 2012 to 2014) and validation (BSIs in 2015) cohorts. A prediction score was built using the coefficients of the multivariate logistic regression model from the derivation cohort. Read More

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http://dx.doi.org/10.3346/jkms.2019.34.e116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460111PMC

Shifting trends and age distribution of ESKAPEEc resistance in bloodstream infection, Southwest China, 2012-2017.

Antimicrob Resist Infect Control 2019 29;8:61. Epub 2019 Mar 29.

1Department of Laboratory Medicine, the First Affiliated Hospital of Chongqing Medical University, No.1, Youyi Road, Yuzhong District, Chongqing, 400016 People's Republic of China.

Background: ESKAPEEc contribute to a majority of bloodstream infections (BSIs) and their antibiogram have changed overtime, while data concerning about these alterations are lacking in China. Added that a paucity of studies referred to ESKAPEEc in pediatric BSIs, our study aimed to demonstrate the longitudinal alterations of ESKAPEEc distribution and antibiogram in adult and pediatric BSIs in Southwest China.

Methods: A multicenter retrospective surveillance study was launched from 2012 to 2017. Read More

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http://dx.doi.org/10.1186/s13756-019-0499-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441235PMC
March 2019
1 Read

Neonatal infection leads to increased susceptibility to Aβ oligomer-induced brain inflammation, synapse loss and cognitive impairment in mice.

Cell Death Dis 2019 Apr 11;10(4):323. Epub 2019 Apr 11.

School of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, 21944-590, Brazil.

Harmful environmental stimuli during critical stages of development can profoundly affect behavior and susceptibility to diseases. Alzheimer disease (AD) is the most frequent neurodegenerative disease, and evidence suggest that inflammatory conditions act cumulatively, contributing to disease onset. Here we investigated whether infection early in life can contribute to synapse damage and cognitive impairment induced by amyloid-β oligomers (AβOs), neurotoxins found in AD brains. Read More

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http://dx.doi.org/10.1038/s41419-019-1529-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459845PMC
April 2019
1 Read

Factors affecting the geographic variability of antibiotic-resistant healthcare-associated infections in the United States using the CDC Antibiotic Resistance Patient Safety Atlas.

Infect Control Hosp Epidemiol 2019 Apr 12:1-3. Epub 2019 Apr 12.

Emory University School of Medicine,Atlanta,Georgia.

We utilized publicly available data from the Centers for Disease Control to explore possible causes of state-to-state variability in antibiotic-resistant healthcare-associated infections. Outpatient antibiotic prescribing rates of fluoroquinolones and cephalosporins explained some variability in extended-spectrum cephalosporin-resistant Escherichia coli after adjusting for differences in age and healthcare facility composition. Read More

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http://dx.doi.org/10.1017/ice.2019.64DOI Listing

New Promising Targets for Synthetic Omptin-Based Peptide Vaccine against Gram-Negative Pathogens.

Vaccines (Basel) 2019 Apr 10;7(2). Epub 2019 Apr 10.

Department of Pathology, Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.

Omptins represent a family of proteases commonly found in various Gram-negative pathogens. These proteins play an important role in host-pathogen interaction and have been recognized as key virulence factors, highlighting the possibility of developing an omptin-based broad-spectrum vaccine. The prototypical omptin, His-tagged recombinant Pla, was used as a model target antigen. Read More

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https://www.mdpi.com/2076-393X/7/2/36
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http://dx.doi.org/10.3390/vaccines7020036DOI Listing
April 2019
5 Reads

Evaluation of adherence and anti-infective properties of probiotic Lactobacillus fermentum strain 4-17 against Escherichia coli causing urinary tract infection in humans.

Microb Pathog 2019 Apr 8. Epub 2019 Apr 8.

Department of Food Science and Technology, Faculty of Agriculture, Ferdowsi University of Mashhad, Mashhad, Iran.

Gastrointestinal (GI) infection is one of the most common types of infectious diseases. Application of probiotic strains in the control of such infections represents a promising approach. In this study, Lactobacillus fermentum strain 4-17 was isolated from kashkineh, an Iranian cereal fermented food, and identified by sequencing its 16S rRNA gene using universal primers. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.04.006DOI Listing
April 2019
2 Reads

Comprehensive Identification of Fim-Mediated Inversions in Uropathogenic Escherichia coli with Structural Variation Detection Using Relative Entropy.

mSphere 2019 04 10;4(2). Epub 2019 Apr 10.

Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

Most urinary tract infections (UTIs) are caused by uropathogenic (UPEC), which depends on an extracellular organelle (type 1 pili) for adherence to bladder cells during infection. Type 1 pilus expression is partially regulated by inversion of a piece of DNA referred to as , which contains the promoter for the operon encoding type 1 pili. inversion is regulated by up to five recombinases collectively known as Fim recombinases. Read More

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http://msphere.asm.org/lookup/doi/10.1128/mSphere.00693-18
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http://dx.doi.org/10.1128/mSphere.00693-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458436PMC
April 2019
2 Reads

Loop-Mediated Isothermal Amplification Assay for Rapid Detection of Hypothetical Protein Gene in Escherichia Coli Clinical Isolates.

Clin Lab 2019 Apr;65(4)

Background: Escherichia coli is the most common pathogenic bacteria that frequently causes life-threatening opportunistic human infections, diarrhea, and septicemia in immunocompromised hosts.

Methods: This study aimed to establish a loop-mediated isothermal amplification (LAMP) method for the rapid and sensitive detection of a hypothetical protein from an E. coli-specific gene (GenBank ID: 13702648). Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180826DOI Listing

Plazomicin Is Active Against Metallo-β-Lactamase-Producing Enterobacteriaceae.

Open Forum Infect Dis 2019 Apr 12;6(4):ofz123. Epub 2019 Mar 12.

Department of Clinical Microbiology, Achaogen, Inc., South San Francisco, California.

Plazomicin is an aminoglycoside that was approved in June 2018 by the US Food and Drug Administration for the treatment of complicated urinary tract infections, including pyelonephritis, due to , , , and . Plazomicin was engineered to overcome the most common aminoglycoside resistance mechanism, inactivation by aminoglycoside-modifying enzymes, but is not active against the less common 16S ribosomal RNA methyltransferases (16S-RMTase), which confer target site modification. As an aminoglycoside, plazomicin maintains activity against Enterobacteriaceae that express resistance mechanisms to other antibiotic classes, including metallo-β-lactamases. Read More

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https://academic.oup.com/ofid/article/doi/10.1093/ofid/ofz12
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http://dx.doi.org/10.1093/ofid/ofz123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446133PMC
April 2019
2 Reads

Ceftolozane/Tazobactam Susceptibility Testing in Extended-Spectrum Betalactamase- and Carbapenemase-Producing Gram-Negative Bacteria of Various Clonal Lineages.

Eur J Microbiol Immunol (Bp) 2019 Mar 8;9(1):1-4. Epub 2019 Feb 8.

Faculty of Health, Center for Clinical and Translational Research, Institute of Medical Laboratory Diagnostics, HELIOS University Clinic Wuppertal, Witten/Herdecke University, Witten, Germany.

Nowadays, multidrug-resistant bacteria are considered as an increasing serious threat to public health worldwide. Global and local surveillance data are helpful in the application of the most efficient antimicrobial agent in bacterial infections. In the current study, we aimed to analyze the activity of the previously cleared agent ceftolozane/ tazobactam (C/T) in African and European multidrug-resistant Gram-negative bacteria. Read More

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https://www.akademiai.com/doi/10.1556/1886.2019.00001
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http://dx.doi.org/10.1556/1886.2019.00001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444803PMC
March 2019
2 Reads

Two Health or Not Two Health? That Is the Question.

Authors:
William P Hanage

MBio 2019 Apr 9;10(2). Epub 2019 Apr 9.

Center for Communicable Disease Dynamics, Department of Epidemiology, Harvard T. H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USA

How much drug-resistant infections in livestock contribute to disease in humans is controversial. While zoonoses are a prominent cause of emerging infections, and the profligate use of antibiotics as growth promoters is expected to lead to the spread of resistance, this resistance could remain concentrated in animal pathogens and only rarely spill over into humans. A recent paper compares genomes of isolates from human bloodstream infections in England, focused on the Cambridge area, with isolates collected from farms and the food chain in the east of the country, seeking evidence of transmission (C. Read More

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http://dx.doi.org/10.1128/mBio.00550-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456756PMC

Synergistic Killing of Pathogenic Escherichia coli Using Camel Lactoferrin from Different Saudi Camel Clans and Various Antibiotics.

Protein J 2019 Apr 8. Epub 2019 Apr 8.

Department of Biological Sciences, Faculty of Sciences, King Abdulaziz University, P.O. Box 80203, Jeddah, Saudi Arabia.

Current study aimed to analyze the synergistic killing of pathogenic Escherichia coli using camel lactoferrin from different Saudi camel clans and various antibiotics. Methods: using multiple microbiological and protein analysis techniques, the results were shown that the purified camel lactoferrins (cLfs) from different Saudi camel have strong antimicrobial potentials against two strains of E. coli. Read More

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http://dx.doi.org/10.1007/s10930-019-09828-5DOI Listing

B cell dynamics during experimental endotoxemia in humans.

Biosci Rep 2019 Apr 8. Epub 2019 Apr 8.

Department of Nephrology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

Recently, B cells with regulatory functions suppressing T cell immunity were identified. Inflammation in the context of sepsis is characterized by a profound immune dysfunction increasing the patient's risk for additional infections. The impact of endotoxemia on B cell dynamics, regulatory B cells and its contribution to immune dysfunction is unknown. Read More

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http://dx.doi.org/10.1042/BSR20182347DOI Listing

Disruption of blood-brain barrier by an Escherichia coli isolated from canine septicemia and meningoencephalitis.

Comp Immunol Microbiol Infect Dis 2019 Apr 9;63:44-50. Epub 2019 Jan 9.

College of Veterinary Medicine, Jilin University, Changchun, Jilin, China; Key laboratory for Zoonoses Research, Ministry of Education, Changchun, Jilin, China. Electronic address:

Escherichia coli (E. coli) is one of the common pathogenic bacteria in veterinary clinical infection. As an opportunistic microorganism, E. Read More

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http://dx.doi.org/10.1016/j.cimid.2019.01.002DOI Listing
April 2019
1 Read

Drug Resistance and Integron Genes in Isolated from Urinary Tract Infection.

J Nanosci Nanotechnol 2019 Sep;19(9):5989-5993

Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, Guangdong 518033, China.

() is a major cause of urinary tract infections. Treatment of these infections with antibiotics is often not effective due to the acquisition of drug-resistance genes by the bacteria. This process is mediated by integrons which belong to bacterial mobile genetic elements. Read More

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https://www.ingentaconnect.com/content/10.1166/jnn.2019.1650
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http://dx.doi.org/10.1166/jnn.2019.16501DOI Listing
September 2019
1 Read

Stimulation of a protease targeting the LRIM1/APL1C complex reveals specificity in complement-like pathway activation in Anopheles gambiae.

PLoS One 2019 8;14(4):e0214753. Epub 2019 Apr 8.

Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

The complement-like pathway of the African malaria mosquito Anopheles gambiae provides protection against infection by diverse pathogens. A functional requirement for a core set of proteins during infections by rodent and human malaria parasites, bacteria, and fungi suggests a similar mechanism operates against different pathogens. However, the extent to which the molecular mechanisms are conserved is unknown. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214753PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453449PMC