53,245 results match your criteria Escherichia Coli Infections


Antimicrobial and anti-biofilm properties of novel synthetic lignan-like compounds.

New Microbiol 2019 Feb 20;42(1). Epub 2019 Feb 20.

Department of Pharmacy, University of Naples Federico II, 80131, Italy.

Antibiotic resistance and biofilm tolerance are among the principal factors involved in the persistence of chronic infections. The need for new antimicrobials is an ever-increasing challenge in clinical environments and in the control of global health. Arylfurans form a set of structures that have been identified in many natural products, e. Read More

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February 2019

Urinary tract infection: Pathogenicity, antibiotic resistance and development of effective vaccines against Uropathogenic Escherichia coli.

Mol Immunol 2019 Feb 18;108:56-67. Epub 2019 Feb 18.

Department of Molecular Biology, Pasteur Institute of Iran, Pasteur Ave., Tehran, 13164, Iran. Electronic address:

Urinary tract infections (UTIs) are recognized as one of the most common infectious diseases in the world that can be divided to different types. Uropathogenic Escherichia coli (UPEC) strains are the most prevalent causative agent of UTIs that applied different virulence factors such as fimbriae, capsule, iron scavenger receptors, flagella, toxins, and lipopolysaccharide for their pathogenicity in the urinary tract. Despite the high pathogenicity of UPEC strains, host utilizes different immune systems such as innate and adaptive immunity for eradication of them from the urinary tract. Read More

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http://dx.doi.org/10.1016/j.molimm.2019.02.007DOI Listing
February 2019

Burden of enterotoxigenic Escherichia coli and shigella non-fatal diarrhoeal infections in 79 low-income and lower middle-income countries: a modelling analysis.

Lancet Glob Health 2019 Mar;7(3):e321-e330

Goodnight Family Department of Sustainable Development, Appalachian State University, Boone, NC, USA; Emerging Pathogens Institute, Gainesville, FL, USA.

Background: Enterotoxigenic Escherichia coli (ETEC) and shigella are two major pathogens that cause moderate-to-severe diarrhoea in children younger than 5 years. Diarrhoea is associated with an increased risk of stunting, which puts children at risk of death due to other infectious diseases.

Methods: We modelled ETEC-related and shigella-related mortality and the effect of moderate-to-severe diarrhoea episodes to determine the number of children with stunting due to these infections in 79 low-income and lower middle-income countries. Read More

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http://dx.doi.org/10.1016/S2214-109X(18)30483-2DOI Listing

Efficacy ratio: A tool to enhance optimal antimicrobial use for intra-abdominal infections.

Indian J Pharmacol 2018 Nov-Dec;50(6):332-335

Department of Clinical Microbiology, Christian Medical College, Vellore, Tamil Nadu, India.

Background: Antimicrobial resistance and inappropriate antibiotic regimen hamper a favorable outcome in intra-abdominal infections. Clinicians rely on the minimum inhibitory concentration (MIC) value to choose from the susceptible antimicrobials. However, the MIC values cannot be directly compared between the different antibiotics because their breakpoints are different. Read More

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http://dx.doi.org/10.4103/ijp.IJP_264_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364343PMC
February 2019

Innate lymphoid cell type 3-derived interleukin-22 boosts lipocalin-2 production in intestinal epithelial cells via synergy between STAT3 and NF-kB.

J Biol Chem 2019 Feb 19. Epub 2019 Feb 19.

Laboratory Medicine (LABMED), Karolinska Institutet, Sweden.

Escherichia coli and Klebsiella pneumoniae are opportunistic pathogens that are commonly associated with infections at mucosal surfaces, such as the lung or the gut. The host response against these types of infections includes the release of epithelial-derived antimicrobial factors such as lipocalin-2 (LCN-2), a protein which specifically inhibits the iron-acquisition of Enterobacteriaceae by binding and neutralizing the bacterial iron-scavenging molecule enterobactin. Regulation of epithelial antimicrobial responses, including the release of LCN-2, has previously been shown to depend on IL-22, a cytokine produced by innate lymphoid cells type 3 (ILC3) during Enterobacteriaceae infections. Read More

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http://dx.doi.org/10.1074/jbc.RA118.007290DOI Listing
February 2019

Pro-inflammatory agents released by pathogens, dying host cells, and neutrophils act synergistically to destroy host tissues: a working hypothesis.

J Inflamm Res 2019 23;12:35-47. Epub 2019 Jan 23.

Department of Pathology, The University of Michigan Medical School, Ann Arbor, MI, USA.

We postulate that the extensive cell and tissue damage inflicted by many infectious, inflammatory and post-inflammatory episodes is an enled result of a synergism among the invading microbial agents, host neutrophils and dead and dying cells in the nidus. Microbial toxins and other metabolites along with the plethora of pro-inflammatory agents released from activated neutrophils massively recruited to the infectious sites and high levels of cationic histones, other cationic peptides, proteinases and Th1 cytokines released from activated polymorphonuclear neutrophils (PMNs) and from necrotized tissues may act in concert (synergism) to bring about cell killing and tissue destruction. Multiple, diverse interactions among the many potential pro-inflammatory moieties have been described in these complex lesions. Read More

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http://dx.doi.org/10.2147/JIR.S190007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350637PMC
January 2019

Urinary infection in the elderly.

Rev Clin Esp 2019 Feb 14. Epub 2019 Feb 14.

Servicio de Medicina Interna, Hospital Universitario Marqués de Valdecilla (HUMV), Santander, Cantabria, España. Electronic address:

Introduction: Urinary tract infections (UTIs) are one of the most frequent infections. In the elderly, they have multiple comorbidities. The objective of this work is to describe the clinical and microbiological epidemiology of elderly persons admitted for UTIs and to evaluate the suitability of empirical treatments and their implications regarding mortality. Read More

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http://dx.doi.org/10.1016/j.rce.2018.10.009DOI Listing
February 2019

Activity of ceftolozane-tazobactam against Pseudomonas aeruginosa and Enterobacterales isolates recovered in Intensive Care Units in Spain: The SUPERIOR multicentre study.

Int J Antimicrob Agents 2019 Feb 12. Epub 2019 Feb 12.

Servicio de Microbiología, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain; Red Española de Investigación en Patología Infecciosa (REIPI), Madrid, Spain. Electronic address:

Patients in intensive care units (ICUs) present a high risk of developing an infection caused by multi-drug resistant (MDR) bacteria. Consequently, new antimicrobials and combinations are needed. We evaluated the activity of ceftolozane-tazobactam against Enterobacterales (n=400) and Pseudomonas aeruginosa (n=80) isolates collected from patients in Spanish intensive care units (ICUs) with complicated urinary tract infections (cUTI) and complicated intra-abdominal infections (cIAI). Read More

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http://dx.doi.org/10.1016/j.ijantimicag.2019.02.004DOI Listing
February 2019
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A Multiepitopic theoretical fusion construct based on in-silico epitope screening of known vaccine candidates for protection against wide range of enterobacterial pathogens.

Hum Immunol 2019 Feb 12. Epub 2019 Feb 12.

Department of Microbiology, Panjab University, Chandigarh, India. Electronic address:

Enterobacterial pathogens that have acquired antibiotic resistance genes are a leading cause of community and hospital acquired infections. In such a situation vaccination is considered as a better option to prevent such infections. In the current study reverse vaccinology approach has been used to select peptides from already known immunogenic proteins to design a chimeric construct. Read More

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http://dx.doi.org/10.1016/j.humimm.2019.02.008DOI Listing
February 2019

Antibiotic resistance: Microbiological profile of urinary tract infections in Mexico.

Cir Cir 2019 ;87(2):176-182

Departamento de Inmunología, Centro de Investigación Biomédica de Occidente. Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, México.

Objective: The objective of this study was to describe the prevalence, microbiological profile, bacterial resistance, and the sensitivity to antibiotics of microorganisms causing urinary tract infection (UTI) at a single-site tertiary referral hospital in the western region of Mexico.

Methods: A total of 5895 culture samples processed at the microbiology laboratory from August 1, 2014, to July 31, 2015, were analyzed.

Results: A total of 5895 samples for urine cultures (UC) were collected, of which 3363 were taken in women (57. Read More

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http://dx.doi.org/10.24875/CIRU.18000494DOI Listing
January 2019
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Chronic prostatitis caused by extended-spectrum β-lactamase-producing managed using oral fosfomycin-A case report.

IDCases 2019 24;15:e00493. Epub 2019 Jan 24.

Faculty of Medicine of the University of Porto, Infectious Diseases department, Centro Hospitalar de São João, Porto, Portugal.

Prostatitis is a clinical condition of difficult management and with limited antimicrobial options, especially in the setting of antimicrobial resistance. Recurrences are frequent and can be severe. Limited reports support the use of fosfomycin for chronic prostatitis by ESBL-producing bacteria. Read More

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http://dx.doi.org/10.1016/j.idcr.2019.e00493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360601PMC
January 2019
1 Read

HIV-exposed uninfected compared with unexposed infants show the presence of leucocytes, lower lactoferrin levels and antimicrobial-resistant micro-organisms in the stool.

Paediatr Int Child Health 2019 Feb 14:1-10. Epub 2019 Feb 14.

a Laboratoire National de Santé Publique , Unités de Recherche et de Diagnostics Spécialisés , Libreville , Gabon.

Background: HIV-exposed uninfected (HEU)-infants have been shown to be particularly vulnerable to infections. In this population, disturbance of the gut micro-environment might increase their susceptibility to enteric diseases and even favour the translocation of bacteria in the bloodstream.

Methods: The gastro-intestinal micro-environment was explored in 22 HEU infants and 16 HIV-unexposed (HU) infants aged 6-24 weeks. Read More

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http://dx.doi.org/10.1080/20469047.2019.1577063DOI Listing
February 2019

Phthalocyanine functionalized poly(glycidyl methacrylate) nano-assemblies for photodynamic inactivation of bacteria.

Biomater Sci 2019 Feb 14. Epub 2019 Feb 14.

State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China. and Key Lab of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology), Ministry of Education, Beijing 100029, China and Beijing Laboratory of Biomedical Materials, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China.

The design of novel antibacterial materials has attracted increasing attention for combating bacterial infections. Herein, we conjugated zinc(ii) monoamino phthalocyanine (ZnMAPc) to poly(glycidyl methacrylate) (PGMA) via a ring-opening reaction, and the excess epoxy groups were scavenged by ethylenediamine (ED). The resultant macro-photosensitizer (PGED-Pc) can be easily dispersed in aqueous solution to form self-assembled nanoparticles and generate reactive oxygen species for inactivation of bacteria when exposed to light illumination. Read More

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http://dx.doi.org/10.1039/c8bm01483cDOI Listing
February 2019

Virulence factors and antimicrobial resistance in uropathogenic Escherichiacoli strains isolated from cystitis and pyelonephritis

Turk J Med Sci 2019 Feb 11;49(1):361-367. Epub 2019 Feb 11.

Background/aim: The aim of this study was to investigate the prevalence of virulence genes as well as patterns of antibiotic resistance in cystitis and pyelonephritis uropathogenic Escherichia coli (UPEC) isolates.

Materials And Methods: Two hundred UPEC isolates were collected from hospitalized patients with pyelonephritis (n = 50) and cystitis (n = 150) in Shafa Hospital in Iran. Antimicrobial susceptibility and ESBL production were determined with confirmatory tests. Read More

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http://dx.doi.org/10.3906/sag-1805-100DOI Listing
February 2019

Monitoring the antimicrobial susceptibility of Gram-negative organisms involved in intraabdominal and urinary tract infections recovered during the SMART study (Spain, 2016 and 2017).

Rev Esp Quimioter 2019 Feb 13. Epub 2019 Feb 13.

Rafael Cantón. Servicio de Microbiología. Hospital Universitario Ramón y Cajal. Carretera de Colmenar Km 9,1. 28034 Madrid. Spain.

Objective: Continuous antimicrobial resistance surveillance is recommended by Public Health authorities. We up-dated data from the SMART (Study for Monitoring Antimicrobial Resistance Trends) surveillance study in Spain.

Methods: The antimicrobial susceptibility data and extended-spectrum beta-lactamase (ESBL) production in isolates recovered from intra-abdominal (IAI) (n=1,429) and urinary tract (UTI) (n=937) infections during the 2016- 2017 SMART study in 10 Spanish hospitals were analysed. Read More

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February 2019

α-haemolysin production, as a single factor, causes fulminant sepsis in a model of Escherichia coli induced bacteraemia.

Cell Microbiol 2019 Feb 13:e13017. Epub 2019 Feb 13.

Department of Biomedicine, Aarhus University, Aarhus C, Denmark.

α-haemolysin (HlyA) from uropathogenic Escherichia coli has been demonstrated to be a significant virulence factor for ascending urinary tract infections. Once the E. coli reach the well-vascularised kidneys, there is a high risk of bacteraemia and a subsequent septic host response. Read More

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http://dx.doi.org/10.1111/cmi.13017DOI Listing
February 2019

Long-term Successful Antibiotic Therapy for Recurrent Aortic Graft Infection.

Eur J Case Rep Intern Med 2018 28;5(8):000913. Epub 2018 Aug 28.

Department of Internal Medicine "C", Assaf Harofeh Medical Center, affiliated to Sackler Medical School, Tel Aviv University, Zerifin, Israel.

Objective: To report a case of successful long-term conservative management of a patient with aortic graft infection due to multiple infectious agents.

Materials And Methods: We describe the clinical case and present a review of relevant literature.

Results: An 82-year-old man presented with recurrent Escherichia coli bacteraemia. Read More

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http://dx.doi.org/10.12890/2018_000913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346835PMC

Occurrence and characterization of Escherichia coli ST410 co-harbouring blaNDM-5, blaCMY-42 and blaTEM-190 in a dog from the UK.

J Antimicrob Chemother 2019 Feb 6. Epub 2019 Feb 6.

Institute of Veterinary Science, University of Liverpool, Leahurst Campus, Cheshire, UK.

Background/objectives: Carbapenemase-producing Enterobacteriaceae (CPE) are a public health threat, and have been found in humans, animals and the environment. Carbapenems are not authorized for use in EU or UK companion animals, and the prevalence of carbapenem-resistant Gram-negative bacilli (CRGNB) in this population is unknown.

Methods: We investigated CRGNB isolated from animal specimens received by one diagnostic laboratory from 34 UK veterinary practices (September 2015-December 2016). Read More

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http://dx.doi.org/10.1093/jac/dkz017DOI Listing
February 2019
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Antibiotics for Ceftriaxone-Resistant Gram-Negative Bacterial Bloodstream Infections.

JAMA 2019 02;321(6):613

Médecine Intensive Réanimation, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France.

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http://dx.doi.org/10.1001/jama.2018.19349DOI Listing
February 2019

Antibiotics for Ceftriaxone-Resistant Gram-Negative Bacterial Bloodstream Infections.

JAMA 2019 02;321(6):612-613

Clinical Microbiology, Central Hospital, Växjö, Sweden.

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http://dx.doi.org/10.1001/jama.2018.19345DOI Listing
February 2019

Some New Findings Regarding the Antiadhesive Activity of Cranberry Phenolic Compounds and Their Microbial-Derived Metabolites against Uropathogenic Bacteria.

J Agric Food Chem 2019 Feb 12. Epub 2019 Feb 12.

Institute of Food Science Research (CIAL) , CSIC-UAM , C/Nicolás Cabrera 9 , 28049 Madrid , Spain.

Findings concerning the antiadhesive activity of cranberry phenolic compounds and their microbial-derived metabolites against Gram-negative ( Escherichia coli ATCC 53503 and DSM 10791) and Gram-positive ( Enterococcus faecalis 04-1) bacteria in T24 cells are reported. A-Type procyanidins (A2 and cinnamtannin B-1) exhibited antiadhesive activity (at concentrations ≥250 μM), a feature that was not observed for B-type procyanidins (B2). The metabolites hippuric acid and α-hydroxyhippuric acid also showed effective results at concentrations ≥250 μM. Read More

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http://dx.doi.org/10.1021/acs.jafc.8b05625DOI Listing
February 2019

Histamine H receptor antagonists enhance the efficacy of antibacterials against Escherichia coli.

BMC Vet Res 2019 Feb 11;15(1):55. Epub 2019 Feb 11.

Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover Foundation, Hannover, Germany.

Background: H receptor antagonists are commonly used for the treatment of allergic diseases. The aim of this study was to find out, if antihistaminic compounds like mepyramine have the ability to influence the activity of antibacterials. Therefore, the checkerboard method was chosen to detect these possible effects in vitro. Read More

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http://dx.doi.org/10.1186/s12917-019-1797-9DOI Listing
February 2019

Whole-genome sequences of multidrug-resistant Escherichia coli in South-Kivu Province, Democratic Republic of Congo: characterization of phylogenomic changes, virulence and resistance genes.

BMC Infect Dis 2019 Feb 11;19(1):137. Epub 2019 Feb 11.

Center for Applied Molecular Technologies, Institute of Clinical and Experimental Research, Université catholique de Louvain, Clos chapelle-aux-champs, 30 B1.30.24, 1200, Brussels, Belgium.

Background: Extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli are responsible for severe infections worldwide. Whereas their genotypic and pathogenic characteristics are not documented in Democratic Republic of Congo (DRC), recent studies conducted at the Bukavu General Hospital in the South Kivu province highlighted their high prevalence in extra-intestinal infections. Here we provide data on molecular characterization of ESBL producing-Escherichia coli isolates from patients with extra-intestinal infections at this provincial hospital. Read More

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http://dx.doi.org/10.1186/s12879-019-3763-3DOI Listing
February 2019
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Utility of Combination Antimicrobial Therapy in Adults with Bloodstream Infections due to Enterobacteriaceae and Non-Fermenting Gram-Negative Bacilli Based on In Vitro Analysis at Two Community Hospitals.

Antibiotics (Basel) 2019 Feb 8;8(1). Epub 2019 Feb 8.

Department of Clinical Pharmacy and Outcomes Sciences, University of South Carolina College of Pharmacy, Columbia, SC 29208, USA.

This study examined the utility of combination therapy for bloodstream isolates of and non-fermenting Gram-negative bacilli (NFGN) from adults at two community hospitals from January 2010 through to June 2015. Changes to in vitro antimicrobial susceptibilities by adding ciprofloxacin or gentamicin to third-generation cephalosporins (3GC) were examined overall and in patients with risk factors for 3GC resistance. Overall ceftriaxone susceptibility among was 996/1063 (94%) and 247/295 (84%) in patients with 3GC resistance risk factors. Read More

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http://dx.doi.org/10.3390/antibiotics8010015DOI Listing
February 2019

Orthopedic Implant-Associated Infection by Multidrug Resistant .

J Clin Med 2019 Feb 8;8(2). Epub 2019 Feb 8.

Department of Clinical Microbiology, Hospital Universitario Fundación Jiménez Díaz. IIS-Fundación Jiménez Díaz, UAM, 28040 Madrid, Spain.

Introduction: Orthopedic implant-associated infections caused by multidrug-resistant are a growing challenge for healthcare providers due to their increasing incidence and the difficulties of medical and surgical treatment.

Material And Methods: A retrospective observational study of all cases of multidrug resistant orthopedic implant-associated infection diagnosed in a tertiary European hospital from December 2011 to November 2017 was carried out. Clinical records were reviewed using a previously designed protocol. Read More

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http://dx.doi.org/10.3390/jcm8020220DOI Listing
February 2019
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[Comparative characteristics of uropathogenic scherichia coli strains, allocated in polyclinic and stationary conditions].

Urologiia 2018 Dec(6):37-44

Institute of Ecology and Genetics of Microorganisms Ural Branch Russian Academy of Sciences, Perm, Russia.

The etiological structure of urinary tract infections (UTI) is determined by the leading role of uropathogenic Escherichia coli (UPEC). The aim of the work is to study the biological properties and phylogenetic diversity of E. coli strains isolated from UTI in outpatient and inpatient patients. Read More

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December 2018

The high prevalence of antibiotic heteroresistance in pathogenic bacteria is mainly caused by gene amplification.

Nat Microbiol 2019 Mar 11;4(3):504-514. Epub 2019 Feb 11.

Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.

When choosing antibiotics to treat bacterial infections, it is assumed that the susceptibility of the target bacteria to an antibiotic is reflected by laboratory estimates of the minimum inhibitory concentration (MIC) needed to prevent bacterial growth. A caveat of using MIC data for this purpose is heteroresistance, the presence of a resistant subpopulation in a main population of susceptible cells. We investigated the prevalence and mechanisms of heteroresistance in 41 clinical isolates of the pathogens Escherichia coli, Salmonella enterica, Klebsiella pneumoniae and Acinetobacter baumannii against 28 different antibiotics. Read More

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http://dx.doi.org/10.1038/s41564-018-0342-0DOI Listing

Structural and Microbiological Characterization of 5-Hydroxy-3,7,4'-Trimethoxyflavone: A Flavonoid Isolated from Vitex gardneriana Schauer Leaves.

Microb Drug Resist 2019 Feb 11. Epub 2019 Feb 11.

1 Department of Biological Chemistry, Regional University of Cariri, Crato, Brazil.

Introduction: Staphylococcus aureus represents the most common etiologic agent of purulent infections, affecting humans and animals. Escherichia coli is one of the principal causes of infectious diseases, mainly diarrheal diseases due to enterotoxin action. There are many reports indicating that these bacteria are multidrug-resistant (MDR) pathogens. Read More

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http://dx.doi.org/10.1089/mdr.2018.0359DOI Listing
February 2019

Appropriate Treatment for Bloodstream Infections Due to Carbapenem-Resistant and : A Nationwide Multicenter Study in Taiwan.

Open Forum Infect Dis 2019 Feb 17;6(2):ofy336. Epub 2018 Dec 17.

Division of Infectious Diseases, Sijhih Cathy General Hospital, New Taipei City, Taiwan.

Background: In a multicenter study from Taiwan, we aimed to investigate the outcome of patients who received different antimicrobial therapy in carbapenem-resistant Enterobacteriaceae bloodstream infections and proposed a new definition for tigecycline use.

Methods: Patients from 16 hospitals in Taiwan who received appropriate therapy for bloodstream infections due to carbapenem-resistant and were enrolled in the study between January 2012 and June 2015. We used a cox proportional regression model for multivariate analysis to identify independent risk factors of 14-day mortality. Read More

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http://dx.doi.org/10.1093/ofid/ofy336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362312PMC
February 2019

Prevalence of Hospital Acquired Infection and its Preventive Practices among Health Workers in a Tertiary Care Hospital.

J Nepal Health Res Counc 2019 Jan 28;16(41):452-456. Epub 2019 Jan 28.

National Trauma Center, Mahaboudha, Kathmandu, Nepal.

Background: Hospital Acquired Infections are major challenge for low and middle income countries which have limited healthcare resources. Literature has explored the prevalence is high and practice is limited. This study aims to assess prevalence and preventive practices of Hospital Acquired Infection among health workers. Read More

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January 2019
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Impacts of chronic and increasing lipopolysaccharide exposure on production and reproductive parameters in lactating Holstein dairy cows.

J Dairy Sci 2019 Feb 6. Epub 2019 Feb 6.

Department of Animal Science, Iowa State University, Ames 50011. Electronic address:

Lipopolysaccharide (LPS) administration causes immunoactivation, which negatively affects production and fertility, but experimental exposure via an acute bolus is unlikely to resemble natural infections. Thus, the objectives were to characterize effects of chronic endotoxemia on production parameters and follicular development in estrous-synchronized lactating cows. Eleven Holstein cows (169 ± 20 d in milk; 681 ± 16 kg of body weight) were acclimated to their environmental surroundings for 3 d and then enrolled in 2 experimental periods (P). Read More

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http://dx.doi.org/10.3168/jds.2018-15631DOI Listing
February 2019

Preparation and Characterization of New Liposomes. Bactericidal Activity of Cefepime Encapsulated into Cationic Liposomes.

Pharmaceutics 2019 Feb 6;11(2). Epub 2019 Feb 6.

Department of Physical Chemistry, University of Seville, 41012 Seville, Spain.

Cefepime is an antibiotic with a broad spectrum of antimicrobial activity. However, this antibiotic has several side effects and a high degradation rate. For this reason, the preparation and characterization of new liposomes that are able to encapsulate this antibiotic seem to be an important research line in the pharmaceutical industry. Read More

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http://dx.doi.org/10.3390/pharmaceutics11020069DOI Listing
February 2019

Rapid time-resolved luminescence based screening of bacteria in urine with luminescence modulating biosensing phages.

Anal Biochem 2019 Feb 5;570:21-26. Epub 2019 Feb 5.

Medicity Research Laboratories and Laboratory of Biophysics, Institute of Biomedicine, Faculty of Medicine, University of Turku, Finland.

Urinary tract infections (UTIs) are a common problem worldwide. The most prevalent causative pathogen of UTI is Escherichia coli, focus of this study. The current golden standard for detecting UTI is bacterial culture, creating a major workload for hospital laboratories - cost-effective and rapid mass screening of patient samples is needed. Read More

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http://dx.doi.org/10.1016/j.ab.2019.01.011DOI Listing
February 2019

Polymicrobial Bacteremia Involving Klebsiella pneumoniae in Patients with Complicated Intra-Abdominal Infections: Frequency, Co-Pathogens, Risk Factors, and Clinical Outcomes.

Surg Infect (Larchmt) 2019 Feb 8. Epub 2019 Feb 8.

1 Department of Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, People's Republic of China.

Background: Klebsiella pneumoniae has gained notoriety because of its high antibiotic resistance and mortality. We compared the clinical features and outcomes of polymicrobial bacteremia involving K. pneumoniae (PBKP). Read More

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http://dx.doi.org/10.1089/sur.2018.207DOI Listing
February 2019
1 Read
1.721 Impact Factor

Emphysematous Pyelonephritis Following Ureterovesical Reimplantation for Congenital Obstructive Megaureter. Pediatric Case Report and Review of the Literature.

Front Pediatr 2019 24;7. Epub 2019 Jan 24.

Pediatrics and Adolescentology Unit, Department of Internal Medicine, University of Pavia and Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

Emphysematous pyelonephritis (EPN) is a rare, life-threatening necrotizing infection of the kidney. To date, very few cases of EPN have been described in the pediatric age. The first case of EPN in a toddler occurring after ureterovesical reimplantation for congenital obstructive megaureter is reported with a literature review. Read More

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https://www.frontiersin.org/article/10.3389/fped.2019.00002/
Publisher Site
http://dx.doi.org/10.3389/fped.2019.00002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354553PMC
January 2019
7 Reads

Using the best available data to estimate the cost of antimicrobial resistance: a systematic review.

Antimicrob Resist Infect Control 2019 1;8:26. Epub 2019 Feb 1.

4University of Chichester, West Sussex, UK.

Background: Valuation of the economic cost of antimicrobial resistance (AMR) is important for decision making and should be estimated accurately. Highly variable or erroneous estimates may alarm policy makers and hospital administrators to act, but they also create confusion as to what the most reliable estimates are and how these should be assessed. This study aimed to assess the quality of methods used in studies that quantify the costs of AMR and to determine the best available evidence of the incremental cost of these infections. Read More

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http://dx.doi.org/10.1186/s13756-019-0472-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359818PMC
February 2019
1 Read

Multifunctional Paper-Based Analytical Device for In Situ Cultivation and Screening of Escherichia coli Infections.

Sci Rep 2019 Feb 7;9(1):1555. Epub 2019 Feb 7.

Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Patumwan, Bangkok, 10330, Thailand.

Point-of-care testing (POCT) for uropathogen detection and chemical screening has great benefits for the diagnosis of urinary tract infections (UTIs). The goal of this study was to develop a portable and inexpensive paper-based analytical device (PAD) for cultivating bacteria in situ and rapidly testing for nitrite on the same device. The PAD was fabricated using a wax printing technique to create a pattern on Whatman No. Read More

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http://dx.doi.org/10.1038/s41598-018-38159-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367442PMC
February 2019
1 Read

Colonization of intestinal microbiota with carbapenemase-producing Enterobacteriaceae in paediatric intensive care units in Cairo, Egypt.

Arab J Gastroenterol 2019 Feb 4. Epub 2019 Feb 4.

Botany and Microbiology Department, Faculty of Science, Cairo University, Cairo, Egypt.

Background And Study Aims: Colonized patients with carbapenamase producing Enterobacteriaceae (CPE) are vulnerable to invasive infections from their endogenous flora. We aimed to assess faecal colonization with (CPE) among children admitted to Cairo University paediatric intensive care units (ICUs). The phenotypic and genotypic characterizations of carbapenemase-producing Enterobacteriaceae were also studied. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S16871979193000
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http://dx.doi.org/10.1016/j.ajg.2019.01.002DOI Listing
February 2019
3 Reads

Study the antibacterial and antibiofilm activity of Carum copticum against antibiotic-resistant bacteria in planktonic and biofilm forms.

Microb Pathog 2019 Feb 4;129:99-105. Epub 2019 Feb 4.

Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman, Iran.

Objectives: Microbial biofilms has attracted interest in the recent years because they has become the most important cause of nosocomial infections. This study was aimed to examine the antibacterial activities of Carum copticum extracts on the development of microbial biofilms and planktonic form of six pathogenic bacteria.

Methods: Antimicrobial activity of the crude extracts against the planktonic form of six pathogenic bacteria: Bacillus cereus, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Acinetobacter baumannii and Klebsiella pneumonia was evaluated by using the disc diffusion method. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.02.002DOI Listing
February 2019
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Recombinant HcpA-EspA-Tir-Stx2B chimeric protein induces immunity against attachment and toxicity of Escherichia coli O157:H7.

Microb Pathog 2019 Feb 5;129:176-182. Epub 2019 Feb 5.

Imam Hossein University, Faculty of Science, Department of Biology, Tehran, Iran.

Background: It is about 4 decades from the identification of Enterohemorrhagic Escherichia coli (EHEC) as a food-borne pathogen. There are many shreds of evidence that the bacteria are significant sources of intestinal infections and outbreaks even in developed countries. Developing an effective vaccine against O157 and non-O157 serotypes of EHEC is a good strategy to combat the bacteria. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.02.004DOI Listing
February 2019

Characterization of the first bla/ermB-carrying IncI1 plasmid from Latin America.

Plasmid 2019 Feb 5;102:1-5. Epub 2019 Feb 5.

Departamento de Bacteriología y Virología, Instituto de Higiene, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay. Electronic address:

Azithromycin represents a valid therapeutic option for gastrointestinal and systemic infections caused by multidrug resistant (MDR) diarrheagenic Escherichia coli, Shigella and Salmonella species. However, acquired macrolide resistance in these species has been increasingly described, mostly related to macrolide modifying enzymes encoded by mph- and erm-type genes. In this study, we characterized the first bla/ermB-carrying IncI1 plasmid from Latin America, which was detected in a MDR E. Read More

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http://dx.doi.org/10.1016/j.plasmid.2019.02.001DOI Listing
February 2019

Virulence related genes and co-enteropathogens associated with clinical outcomes of enteropathogenic infections in children from Brazilian semiarid region: a case-control study of diarrhea.

J Clin Microbiol 2019 Feb 6. Epub 2019 Feb 6.

Institute of Biomedicine for Brazilian Semiarid, Federal University of Ceará, Fortaleza, Brazil,1315 Coronel Nunes de Melo, zipcode: 60430-270.

Enteropathogenic (EPEC) is a major cause of diarrhea in children from developing countries and presents high genetic variability. We aimed to characterize EPEC virulence-related gene (VRG) distribution and copathogens associated with diarrhea and nutrition-related outcomes in children from the low-income Brazilian semiarid region. A cross-sectional case-control study of diarrhea was conducted in 1,191 children aged 2-36 months old from the Northeast Region of Brazil. Read More

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http://dx.doi.org/10.1128/JCM.01777-18DOI Listing
February 2019
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Dietary restriction of iron availability attenuates UPEC pathogenesis in a mouse model of urinary tract infection.

Am J Physiol Renal Physiol 2019 Feb 6. Epub 2019 Feb 6.

Obstetrics and Gynecology, Washington University School of Medicine, United States.

Iron is a critical nutrient required by hosts and pathogens. Uropathogenic Escherichia coli (UPEC), the principal causative agent of urinary tract infections (UTIs), chelate iron for their survival and persistence. Here, we demonstrate that dietary modulation of iron availability limits UPEC burden in a mouse model of UTI. Read More

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http://dx.doi.org/10.1152/ajprenal.00133.2018DOI Listing
February 2019
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Bloodstream infections due to carbapenemase-producing Enterobacteriaceae in Italy: results from nationwide surveillance, 2014 to 2017.

Euro Surveill 2019 Jan;24(5)

Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.

Following the rapid increase of infections due to carbapenemase-producing Enterobacteriaceae (CPE) in Italy, the national surveillance of bloodstream infections (BSI) due to CPE ( and ) was instituted in 2013. All CPE-BSI cases reported to the surveillance in the years 2014-17 were analysed in order to investigate incidence rate (IR), trend, main individual characteristics and enzymes involved in CPE resistance. Throughout this period, 7,632 CPE-BSI cases (IR: 3. Read More

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http://dx.doi.org/10.2807/1560-7917.ES.2019.24.5.1800159DOI Listing
January 2019

Influence of poly-L-lysine molecular weight on antibacterial efficacy in polymer multilayer films.

J Biomed Mater Res A 2019 Feb 4. Epub 2019 Feb 4.

School of Engineering, Brown University, Providence, RI.

Antibacterial coatings can prevent and treat medical device-associated infections. We examined the antibacterial properties of coatings assembled from poly-L-lysine (PLL) and hyaluronic acid (HA). (PLL/HA) films were fabricated using layer-by-layer assembly with three different PLL MWs, differentiated by number of repeat units, i. Read More

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http://dx.doi.org/10.1002/jbm.a.36645DOI Listing
February 2019

Antibacterial Potential of (Aloeacea) Leaf Latex against Gram-Positive and Gram-Negative Bacteria Strains.

Int J Microbiol 2019 2;2019:5328238. Epub 2019 Jan 2.

School of Pharmacy, College of Medicine and Health Science, Wollo University, Dessie, Ethiopia.

Objective: To evaluate the antibacterial effects of the leaf latex of against infectious bacterial strains.

Methods: The leaf latex of at different concentrations (400, 500, and 600 mg/ml) was evaluated for antibacterial activities using the disc diffusion method against some Gram-negative species such as (ATCC 14700) and (ATCC 35619) and Gram-positive such as (ATCC 50080) and (ATCC 4623).

Results: The tested concentrations of the latex ranging between 400 and 600 mg·mL showed significant antibacterial activity against bacterial strain. Read More

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http://dx.doi.org/10.1155/2019/5328238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334358PMC
January 2019

Minor sequence modifications in temporin B cause drastic changes in antibacterial potency and selectivity by fundamentally altering membrane activity.

Sci Rep 2019 Feb 4;9(1):1385. Epub 2019 Feb 4.

Institute of Pharmaceutical Science, School of Cancer & Pharmaceutical Science, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, SE1 9NH, United Kingdom.

Antimicrobial peptides (AMPs) are a potential source of new molecules to counter the increase in antimicrobial resistant infections but a better understanding of their properties is required to understand their native function and for effective translation as therapeutics. Details of the mechanism of their interaction with the bacterial plasma membrane are desired since damage or penetration of this structure is considered essential for AMPs activity. Relatively modest modifications to AMPs primary sequence can induce substantial changes in potency and/or spectrum of activity but, hitherto, have not been predicted to substantially alter the mechanism of interaction with the bacterial plasma membrane. Read More

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http://dx.doi.org/10.1038/s41598-018-37630-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362004PMC
February 2019

Susceptibility breakpoint for Danofloxacin against swine Escherichia coli.

BMC Vet Res 2019 Feb 4;15(1):51. Epub 2019 Feb 4.

Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development. Faculty of Basic Veterinary Science, College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Road, Xiangfang District, Harbin, People's Republic of China.

Background: Improper use of antimicrobials results in poor treatment and severe bacterial resistance. Breakpoints are routinely used in the clinical laboratory setting to guide clinical decision making. Therefore, the objective of this study was to establish antimicrobial susceptibility breakpoints for danofloxacin against Escherichia coli (E. Read More

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http://dx.doi.org/10.1186/s12917-019-1783-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360659PMC
February 2019
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Antimicrobial characteristics and biocompatibility of the surgical sutures coated with biosynthesized silver nanoparticles.

Bioorg Chem 2018 Dec 27;86:254-258. Epub 2018 Dec 27.

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gazi University, Ankara, Turkey. Electronic address:

Surgical sutures play important role during the wound healing of the surgical sites which are known to be sensitive to microbial infections. Silver nanoparticles (AgNPs) have been recently used as promising agents against multiple-drug resistant microorganisms. This study was designed to coat the sutures with silver nanoparticles obtained via a green synthesis approach. Read More

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http://dx.doi.org/10.1016/j.bioorg.2018.12.034DOI Listing
December 2018
2 Reads