3,050 results match your criteria Erythroderma Generalized Exfoliative Dermatitis


General characteristics, economic burden, causative drugs and medical errors associated with medical damage litigation involving severe cutaneous adverse drug reactions in China.

J Clin Pharm Ther 2020 Jun 9. Epub 2020 Jun 9.

Hemopurification Center, Division of Nursing, Tongde Hospital of Zhejiang Province, Hangzhou, China.

What Is Known And Objective: To investigate the general characteristics, economic burden, causative drugs and medical errors associated with litigation involving severe cutaneous adverse drug reactions (SCADRs) in China, with the aims of improving rational medication use and reducing the extent of damage from SCADRs.

Methods: This study analysed 150 lawsuit judgements involving SCADRs from 2005 to 2019, collected from China Judgments Online.

Results And Discussion: In total, 50% of lawsuits stemmed from SCADRs occurring in general hospitals. Read More

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http://dx.doi.org/10.1111/jcpt.13174DOI Listing

European Medicines Agency review of midostaurin (Rydapt) for the treatment of adult patients with acute myeloid leukaemia and systemic mastocytosis.

ESMO Open 2019 11;4(6)

European Medicines Agency, Amsterdam, The Netherlands.

On 18 September 2017, a marketing authorisation valid through the European Union (EU) was issued for midostaurin in combination with standard daunorubicin and cytarabine induction and high-dose cytarabine consolidation chemotherapy and for patients in complete response followed by midostaurin single agent maintenance therapy, for adult patients with newly diagnosed acute myeloid leukaemia (AML) who are Fms-like tyrosine kinase 3 mutation positive and as monotherapy for the treatment of adult patients with aggressive systemic mastocytosis (ASM), systemic mastocytosis with associated haematological neoplasm (SM-AHN) or mast cell leukaemia (MCL). The recommended dose of midostaurin is 50 mg orally twice daily for AML and 100 mg orally twice daily for ASM, SM-AHN and MCL. Midostaurin was evaluated in two pivotal studies. Read More

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http://dx.doi.org/10.1136/esmoopen-2019-000606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001097PMC
November 2019

Tinea Corporis-associated Erythroderma: Case Report and Review of Erythrodermic Patients with Chronic Dermatophyte Infection.

Cureus 2020 Apr 7;12(4):e7578. Epub 2020 Apr 7.

Dermatology, San Diego Family Dermatology, National City, USA.

Erythroderma presents as generalized skin redness. The features of a 39-year-old man who presented with erythroderma are described. His skin biopsy revealed hyphae in the stratum corneum, which established the diagnosis of tinea corporis. Read More

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http://dx.doi.org/10.7759/cureus.7578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205383PMC

Exfoliative Erythroderma: An Unusual Presentation of Paraneoplastic Pemphigus Associated with Castleman's Disease.

Case Rep Dermatol 2020 Jan-Apr;12(1):76-81. Epub 2020 Apr 14.

Division of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

We report a 23-year-old woman who presented with generalized scaly erythematous rash predominately on the upper trunk and hemorrhagic stomatitis. The histopathologic and immunopathologic findings were consistent with the diagnosis of paraneoplastic pemphigus. Castleman's tumor was diagnosed with computed tomography and exploratory laparotomy. Read More

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http://dx.doi.org/10.1159/000507357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184796PMC

Seroprevalence, Clinical, and Pathological Characteristics of Canine Leishmaniasis in a Central Region of Colombia.

J Vet Res 2020 Mar 14;64(1):85-94. Epub 2020 Feb 14.

Immunobiology and Pathogenesis Research Group, Faculty of Veterinary Medicine, University of Tolima, Altos de Santa Helena, Ibagué, Colombia.

Introduction: Leishmaniasis is a zoonotic disease which is caused by protozoan parasites of the genus . Canids are the most important reservoir of the parasites; however, limited data are available on the species of prevalent in these animals and their impact on human health. The objective of this study was to estimate the seroprevalence of leishmaniasis in dogs from an inter-Andean region of Colombia during July 2016-July 2017, and to describe the clinical and histopathological features of the disease. Read More

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http://dx.doi.org/10.2478/jvetres-2020-0011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105987PMC

A Case of Sebaceous Adenitis and Concurrent Meibomian Gland Dysfunction in a Dog.

Vet Sci 2020 Apr 2;7(2). Epub 2020 Apr 2.

Veterinary Ophthalmology Referrals, Centro Veterinario Torinese, 10153 Turin, Italy.

Sebaceous adenitis and concurrent meibomian gland dysfunction (MGD) were diagnosed in a two-year-old mongrel dog presenting with hypotrichosis, exfoliative dermatitis and blepharitis. Diagnosis of sebaceous adenitis was based on history, clinical signs, the histological demonstration of multifocal lymphohistiocytic and neutrophilic inflammation targeting the sebaceous glands and sebaceous glands loss. MGD was diagnosed by non-contact infrared meibography followed by tear film lipid layer interferometric evaluation. Read More

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http://dx.doi.org/10.3390/vetsci7020037DOI Listing

Yeasts in Veterinary Dermatology: An Updated Overview.

Front Cell Infect Microbiol 2020 28;10:79. Epub 2020 Feb 28.

Department of Clinical Sciences and Services, Royal Veterinary College, Hatfield, United Kingdom.

Lipophilic yeasts of the genus are important skin commensals and opportunistic skin pathogens in a variety of animals. The species was first isolated from the skin of a captive Indian rhinoceros with an exfoliative dermatitis in 1925, recognized as an important otic pathogen of dogs in the 1950's, and finally accepted, after several years of controversy, as a common cause of canine dermatitis in the 1990's. Since then, there has been considerable research into the biology of yeasts and their interaction with their animal hosts. Read More

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http://dx.doi.org/10.3389/fcimb.2020.00079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059102PMC
February 2020

Clinical and histological recovery of non-thymoma-associated exfoliative dermatitis in a cat treated with ciclosporin A.

JFMS Open Rep 2020 Jan-Jun;6(1):2055116920902307. Epub 2020 Feb 11.

Department of Clinical Sciences, Université de Toulouse, ENVT, Toulouse, France; UDEAR, Université de Toulouse, INSERM, ENVT, Toulouse, France.

Case Summary: A 6-year-old neutered female European Shorthair cat was referred for chronic, moderately pruritic, alopecic and exfoliative dermatosis that was unresponsive to antiparasitic, antibiotic or steroidal anti-inflammatory drugs. The cat presented with truncular alopecia and numerous whitish adherent scales covering the whole body. Differential diagnoses included sebaceous adenitis, dermatophytosis, demodicosis, exfoliative dermatitis associated or not with thymoma, drug reaction, feline immunodeficiency virus- or feline leukaemia virus-associated dermatoses, epitheliotropic T-cell lymphoma, and yeasts and/or bacterial overgrowth. Read More

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http://dx.doi.org/10.1177/2055116920902307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013115PMC
February 2020

Familial "benign" pemphigus? Erythroderma and fatal outcome.

An Bras Dermatol 2020 Jan - Feb;95(1):75-77. Epub 2019 Nov 25.

Dermatology Service, Universidade Federal de Ciências da Saúde, Porto Alegre, RS, Brazil; School of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.

Hailey-Hailey disease, or familial benign pemphigus, is a rare bullous genodermatosis that usually presents with flaccid blisters, erosions, and maceration limited to flexural areas, resulting in increased morbidity and reduced quality of life for affected patients. The authors report an unusual case of generalized Hailey-Hailey disease with erythroderma and fatal outcome. Read More

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http://dx.doi.org/10.1016/j.abd.2019.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058835PMC

Erythroderma as first manifestation of squamous cell lung cancer: rare case report.

An Bras Dermatol 2020 Jan - Feb;95(1):67-70. Epub 2019 Dec 31.

Hospital Universitari Sagrat Cor-Grupo Quirónsalud, Barcelona, Spain.

Erythroderma as the first manifestation of a solid organ malignancy is rare. The underlying cancer is a challenging condition to diagnose. There are a few cases of erythroderma in cancer patients reported in the literature. Read More

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http://dx.doi.org/10.1016/j.abd.2019.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058868PMC
March 2020
0.866 Impact Factor

Satisfactory response of a back carbuncle to 5-aminolevulinic acid (ALA) photodynamic therapy: A case report.

Photodiagnosis Photodyn Ther 2020 Jun 10;30:101618. Epub 2019 Dec 10.

Department of Dermatology and Venereology, Nanjing Medical University Affiliated Wuxi People's Hospital, Wuxi, 214023, China. Electronic address:

Carbuncle, a collection of interconnected furuncles with multiple pustular openings, is usually caused by Staphylococcus aureus (S. aureus). In this condition, both skin and subcutaneous tissue of the lesion show severe inflammation. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2019.101618DOI Listing
June 2020
2.014 Impact Factor

Disseminated bullous impetigo and atopic dermatitis: Case series and literature review.

Pediatr Dermatol 2020 Jan 22;37(1):103-108. Epub 2019 Nov 22.

Division of Pediatric Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Background: Bullous impetigo (BI) is a common skin infection of early childhood, resulting from desmoglein-1 cleavage by Staphylococcus aureus exfoliative toxins. Due to compromised barrier function and immune dysregulation, children with atopic dermatitis (AD) are at increased risk of cutaneous infections, yet no literature has been published on disseminated bullous impetigo (DBI) in children with atopic dermatitis (AD). We sought to explore the atopic phenotypes, antibiotic sensitivities, and treatment courses of children diagnosed with disseminated bullous impetigo at our institution. Read More

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http://dx.doi.org/10.1111/pde.14032DOI Listing
January 2020

Lichenoid drug reaction due to anti-tubercular therapy presenting as erythroderma.

Dermatol Ther 2020 01 10;33(1):e13169. Epub 2019 Dec 10.

Department of Pathology, PGIMER Dr RML Hospital, New Delhi, India.

First-line anti-tubercular therapy (ATT) is very effective in management of tuberculosis and is usually well tolerated. Varied spectrum of cutaneous adverse drug reactions is associated with ATT, of which lichenoid drug eruption (LDR) constitutes approximately 10% of the cases. However, LDR presenting as erythroderma is very rare. Read More

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http://dx.doi.org/10.1111/dth.13169DOI Listing
January 2020

Keratinocytes apoptosis contributes to crizotinib induced-erythroderma.

Toxicol Lett 2020 Feb 7;319:102-110. Epub 2019 Nov 7.

Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address:

Crizotinib is a multi-target receptor tyrosine kinase inhibitor which is of great importance for the management of ALK-rearranged non-small cell lung cancer (NSCLC) patients. Serious erythroderma and toxic epidermal necrolysis have been reported associated with crizotinib treatment. The underlying mechanisms have not been examined. Read More

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http://dx.doi.org/10.1016/j.toxlet.2019.11.007DOI Listing
February 2020

Erythroderma secondary to pityriasis rubra pilaris.

Indian J Med Res 2019 08;150(2):206-207

Department of Dermatology, Hospital Regional Universitario de Málaga, Málaga, Spain.

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http://dx.doi.org/10.4103/ijmr.IJMR_294_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829778PMC

Thymoma-associated exfoliative dermatitis in a goat: case report and brief literature review.

J Vet Diagn Invest 2019 Nov 25;31(6):905-908. Epub 2019 Oct 25.

Departments of Microbiology, Immunology, and Pathology (Byas, Frank), College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO.

A Rock Alpine doe () was presented to the Colorado State University Veterinary Teaching Hospital because of scaling and ulceration over the withers, coronary bands, and dewclaws. The doe was euthanized because of poor prognosis associated with a radiographically identified cranial mediastinal mass, increased respiratory effort, and discomfort. Autopsy revealed a cranial mediastinal mass, and scaling-to-ulcerative lesions affecting the dorsum, ventrum, pinna, neck, teats, coronary bands, and dewclaws. Read More

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http://dx.doi.org/10.1177/1040638719884957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900714PMC
November 2019

Generalized Skin Scaling in a Young Girl: A Quiz.

Acta Derm Venereol 2019 Dec;99(13):1322-1323

Department of Dermatology, Peking University First Hospital, 100034 Beijing, China.

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http://dx.doi.org/10.2340/00015555-3339DOI Listing
December 2019

Norwegian scabies presenting as erythroderma in HIV: A case report.

Infez Med 2019 Sep;27(3):332-335

Department of Dermatology and Venereology, Andreas Sygros Hospital, Athens, Greece.

Crusted scabies is a rare and extreme manifestation of scabies that is observed mainly among immunosuppressed patients. We describe the case of a 55-year-old patient with a history of HIV infection and injection drug use. The patient was not on any antiretroviral therapy during the previous year, was malnourished and was living in unsanitary conditions. Read More

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September 2019
1 Read

Diffuse Exfoliative Rash with Sepsis and Eosinophilia: A Case of Erythroderma?

Am J Case Rep 2019 Sep 20;20:1387-1393. Epub 2019 Sep 20.

Graduate Medical Education, University of Central Florida College of Medicine, Orlando, FL, USA.

BACKGROUND Erythroderma is an exfoliative dermatitis that manifests as generalized erythema and scaling that involves 90% of the body surface. If untreated, erythroderma can be fatal because of its metabolic burden and risk of secondary infections. CASE REPORT The patient was a 56-year-old male with prior rash attributed to group A Streptococcal cellulitis and discharged on Augmentin, Clindamycin with hydrocortisone cream, and Bactrim, but he had been noncompliant. Read More

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http://dx.doi.org/10.12659/AJCR.917427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761706PMC
September 2019
5 Reads

Perils with Pirfenidone and "the tuberculosis link".

Int J Mycobacteriol 2019 Jul-Sep;8(3):298-301

Department of Medicine, Kasturba Medical College, MAHE, Mangalore, Karnataka, India.

We report a case of idiopathic pulmonary fibrosis (IPF) treated with pirfenidone who developed tuberculosis (TB) and later had exfoliative dermatitis secondary to an interaction between pirfenidone and rifampicin. This case report highlights the possible risk of developing TB in patients diagnosed with IPF and on antifibrotic therapy like pirfenidone. Furthermore, this case report documents a previously unreported adverse reaction due to the interaction of rifampicin with pirfenidone. Read More

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http://dx.doi.org/10.4103/ijmy.ijmy_96_19DOI Listing
January 2020
3 Reads

Erythroderma as a paraneoplastic manifestation of small cell lung cancer.

Curr Probl Cancer 2020 Apr 30;44(2):100499. Epub 2019 Aug 30.

Department of Internal Medicine, University Hospital of Heraklion, Heraklion, Crete, Greece.

Erythroderma is a rare clinical entity characterized by generalized erythema affecting the whole or most of the body's skin surface. It is associated with a variety of underlying conditions, including preexisting dermatoses, infections, connective tissue disorders, drugs, malignancies, or it may be idiopathic. A case of a 73-year-old man, with a 5-month history of erythroderma, eventually diagnosed with small cell lung cancer is presented. Read More

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http://dx.doi.org/10.1016/j.currproblcancer.2019.100499DOI Listing
April 2020
8 Reads

A novel homozygous nonsense mutation in CAST associated with PLACK syndrome.

Cell Tissue Res 2019 Nov 7;378(2):267-277. Epub 2019 Aug 7.

Faculty of Arts and Sciences, Department of Molecular Biology and Genetics, University of Acibadem, Istanbul, Turkey.

Peeling skin syndrome is a heterogeneous group of rare disorders. Peeling skin, leukonychia, acral punctate keratoses, cheilitis and knuckle pads (PLACK syndrome, OMIM616295) is a newly described form of PSS with an autosomal recessive mode of inheritance. We report a 5. Read More

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http://dx.doi.org/10.1007/s00441-019-03077-9DOI Listing
November 2019

Imatinib Mesylate Induced Erythroderma.

J Assoc Physicians India 2018 Dec;66(12):79-80

Consulting Oncologist, KLES Dr. Prabhakar Kore Hospital, Belgaum, Karnataka.

Imatinib, a specific tyrosine kinase inhibitor is a new anticancer agent, which has shown excellent efficacy in managing chronic myeloid leukemia. It is well tolerated with few side effects. Commonest adverse events are maculopapular eruptions and periorbital edema were reported. Read More

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December 2018
7 Reads

Whole exome sequencing approach to childhood onset familial erythrodermic psoriasis unravels a novel mutation of CARD14 requiring unusual high doses of ustekinumab.

Pediatr Rheumatol Online J 2019 Jul 8;17(1):38. Epub 2019 Jul 8.

Centro Malattie Autoinfiammatorie e Immunodeficienze- Clinica Pediatrica e Reumatologia, IRCCS Giannina Gaslini, Via Gaslini 5, 16147, Genova, Italy.

Background: Autosomal dominant gain of function mutations in caspase recruitment domain family member 14 (CARD14) is a rare condition associated with plaque-type psoriasis, generalized pustular psoriasis, palmoplantar pustular psoriasis and pityriasis rubra pilaris. Recently, a new CARD14 -associated phenotype defined as CAPE (CARD14-associated papulosquamous eruption) with clinical features of both psoriasis and pityriasis rubra pilaris was reported. We describe a family carrying a novel heterozygous mutation in CARD14 gene, with childhood-onset erythrodermic psoriasis requiring an unusual extremely high dose (up to 2 mg/kg every 8 weeks) of ustekinumab to achieve disease remission. Read More

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http://dx.doi.org/10.1186/s12969-019-0336-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615224PMC
July 2019
7 Reads

Pustules on the back possibly triggering toxic-shock syndrome.

BMJ Case Rep 2019 Jun 29;12(6). Epub 2019 Jun 29.

Department of General Internal Medicine, Saiseikai Senri Hospital, Suia, Japan.

We herein describe an irregular case of toxic-shock syndrome (TSS). A previously healthy 28-year-old Japanese man developed a sudden-onset high fever. The patient was suffering from conjunctival hyperaemia, gastrointestinal symptoms such as vomiting and diarrhoea, and systemically diffused macular erythroderma. Read More

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http://dx.doi.org/10.1136/bcr-2019-229610DOI Listing
June 2019
4 Reads

A rare and severe cutaneous adverse effect of telaprevir: drug rash with eosinophilia and systemic symptoms.

G Ital Dermatol Venereol 2019 Aug;154(4):488-491

Department of Dermatology, Bezmialem Vakif University, Istanbul, Turkey.

Telaprevir is a specific inhibitor of the hepatitis C (HCV) serine protease 3. Cutaneous side effects have been reported with telaprevir. Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare yet severe adverse drug-induced reaction characterized by exfoliative dermatitis and maculopapular rash, lymphadenopathy, fever, eosinophilia, leukocytosis, and myriad internal organ involvement. Read More

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https://www.minervamedica.it/index2.php?show=R23Y2019N04A048
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http://dx.doi.org/10.23736/S0392-0488.17.05151-3DOI Listing
August 2019
9 Reads

[Erythroderma revealing IPEX syndrome].

Ann Dermatol Venereol 2019 Dec 21;146(12):807-811. Epub 2019 Jun 21.

Service de dermatologie, université Clermont-Auvergne, CHU de Clermont-Ferrand, 63000 Clermont-Ferrand, France.

Background: Primary immunodeficiencies are rare and frequently life-threatening conditions in the first year of life. They may present with isolated skin manifestations and the absence of other clinical signs may delay diagnosis and management of the disease. Herein we describe a case of IPEX syndrome (Immune dysregulation, Polyendocrinopathy, Enteropathy, X-linked syndrome) that illustrates this situation. Read More

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http://dx.doi.org/10.1016/j.annder.2019.04.026DOI Listing
December 2019
25 Reads

Therapeutic options and prognosis of chronic idiopathic erythroderma in older adults.

Dermatol Ther 2019 07 17;32(4):e12977. Epub 2019 Jun 17.

Department of Dermatology, Fukuoka University Faculty of Medicine, Fukuoka, Japan.

The present authors have previously reported that chronic idiopathic erythroderma (CIE) that lasts for more than 3 months without specific causes occurs almost exclusively in older men. No standardized therapeutic treatments for the condition have been established to date. To assess the efficacies and safeties of current treatments for CIE, the present authors reviewed cases of CIE. Read More

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http://dx.doi.org/10.1111/dth.12977DOI Listing
July 2019
9 Reads

Paraneoplastic erythroderma: unusual presentation secondary to diffuse large B cell lymphoma.

BMJ Case Rep 2019 May 30;12(5). Epub 2019 May 30.

Department of Dermatology, Nottingham University Hospitals NHS Trust, Nottingham, UK.

A 34-year-old HIV-positive man presented in clinic with generalised erythroderma, having been lost to follow-up for the previous 3 years. He was CD4 lymphopenic (100×10/L) and was antiretroviral therapy naive. Initial histology from a skin punch biopsy was non-specific and he was treated with topical steroids and emollients for a suspected eczema. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22841
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http://dx.doi.org/10.1136/bcr-2018-228412DOI Listing
May 2019
26 Reads

Granuloma formation clinically presenting as erythroderma in a patient with peripheral T-cell lymphoma.

Eur J Dermatol 2019 Jun;29(3):324-326

Division of Dermatology, Department of Medicine of Sensory and Motor Organs, Faculty of Medicine, Tottori University, Yonago.

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http://dx.doi.org/10.1684/ejd.2019.3544DOI Listing
June 2019
3 Reads

Adalimumab-induced erythrodermic reactions.

Int J Dermatol 2019 Oct 28;58(10):e204-e206. Epub 2019 May 28.

Department of Dermatology, Mayo Clinic, Rochester, MN, USA.

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http://dx.doi.org/10.1111/ijd.14503DOI Listing
October 2019
2 Reads

Methotrexate for papuloerythroderma of Ofuji.

Clin Exp Dermatol 2020 Mar 21;45(2):241-243. Epub 2019 May 21.

Department of Dermatology, Kingston Hospital NHS Foundation Trust, London, UK.

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http://dx.doi.org/10.1111/ced.13997DOI Listing

Squamous cell carcinoma antigen is useful in the differential diagnosis of erythroderma.

Int J Dermatol 2019 Aug 20;58(8):e158-e159. Epub 2019 May 20.

Department of Dermatology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.

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http://dx.doi.org/10.1111/ijd.14498DOI Listing
August 2019
1 Read

Severe dermatitis, multiple allergies and metabolic wasting (SAM) syndrome caused by de novo mutation in the DSP gene misdiagnosed as generalized pustular psoriasis and treatment of acitretin with gabapentin.

J Dermatol 2019 Jul 20;46(7):622-625. Epub 2019 May 20.

Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Severe dermatitis, multiple allergies and metabolic wasting (SAM) syndrome is a recently recognized syndrome caused by mutations in the desmoglein 1 (DSG1) and desmoplakin (DSP) genes. Only two cases of SAM-DSP have been reported. We report on a 2-year-old girl presenting with pustular lakes within areas of erythema and large accumulations of intraepidermal neutrophils, which initially led to our misdiagnosis of generalized pustular psoriasis. Read More

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http://dx.doi.org/10.1111/1346-8138.14925DOI Listing
July 2019
15 Reads

Treatment of exfoliative cutaneous lupus erythematosus in a German shorthaired pointer dog with mycophenolate mofetil.

Vet Dermatol 2019 Aug 30;30(4):350-e102. Epub 2019 Apr 30.

Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, 2200 College Station Road, Athens, GA, 30602, USA.

Background: Immune-modulating drugs show limited therapeutic efficacy in canine exfoliative cutaneous lupus erythematosus (ECLE); over half of ECLE dogs are eventually euthanized for their lack of response to therapy.

Objective: To describe a case of generalized ECLE in a dog in which mycophenolate mofetil (MMF) treatment achieved complete remission.

Animal: A 3-year-old, male castrated German shorthaired pointer was presented with a three months history of generalized scaling, erythematous macules and plaques, follicular casts and hypotrichosis affecting the head, trunk, ventrum and medial aspects of all limbs. Read More

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http://dx.doi.org/10.1111/vde.12747DOI Listing
August 2019
31 Reads

Novel DSP Spectrin 6 Region Variant Causes Neonatal Erythroderma, Failure to Thrive, Severe Herpes Simplex Infections and Brain Lesions.

Acta Derm Venereol 2019 Jul;99(9):789-796

Children's Hospital, University of Helsinki and Helsinki University Hospital, FIN-00290 Helsinki, Finland.

Desmoplakin (DSP) and Desmoglein 1 (DSG1) variants result in skin barrier defects leading to erythroderma, palmoplantar keratoderma and variable [AQ4] other features. Some DSG1 variant carriers present with SAM syndrome (Severe dermatitis, multiple Allergies, Metabolic wasting) and a SAM-like phenotype has been reported in 4 subjects with different heterozygous DSP variants. We report here a patient with a novel DSP spectrin region (SR) 6 variant c. Read More

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http://dx.doi.org/10.2340/00015555-3203DOI Listing
July 2019
12 Reads

Progressive Erythroderma without Malignancy in the Skin: A Quiz.

Acta Derm Venereol 2019 Jul;99(9):841-843

Department of Dermatology, Kyoto University Graduate School of Medicine, 606-8507 Kyoto, Japan.

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http://dx.doi.org/10.2340/00015555-3206DOI Listing
July 2019
5 Reads

Iatrogenic pediatric hydroxocobalamin overdose.

Am J Emerg Med 2019 07 10;37(7):1394.e1-1394.e2. Epub 2019 Apr 10.

University of Washington, Department of Emergency Medicine, United States of America.

Introduction: Hydroxocobalamin, a precursor molecule to vitamin B12, has emerged as the preferred empiric treatment for patients rescued from enclosed-space fires with concern for inhalational injury and potential concomitant cyanide toxicity. Limited data exist on the effects of hydroxocobalamin toxicity, particularly in pediatric patients.

Case Report: We report a case of a healthy three-year old girl who was rescued from an apartment fire and electively intubated by prehospital providers. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07356757193023
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http://dx.doi.org/10.1016/j.ajem.2019.04.012DOI Listing
July 2019
29 Reads

[Lamotrigine induced hypersensitivity syndrome in children: a case report].

Authors:
N X Cui X P Zhu

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):356-358

Department of Neonatology, Children's Hospital of Soochow University, Suzhou 215025, Jiangsu, China.

Drug induced hypersensitivity syndrome (DIHS) is often manifested as severe systemic drug trans-reactions characterized by acute and extensive skin lesions (mostly measles-like rash), fever, enlargement of lymph nodes, multiple organ involvement (hepatitis, nephritis, and pneumonia), eosinophilia and mononucleosis,within 2-6 weeks of the application of sensitizing drugs. In the early stage of the lesion, macular papules or erythema multiforme were common, and in severe cases, exfoliative dermatitis, Stevens-Johnson syndrome and toxic epidermal necrolysis were also common. Most of them developed after taking allergic drugs for 2-6 weeks (average: 3 weeks). Read More

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April 2019
31 Reads

Non-endemic erythrodermic pemphigus foliaceus: a case with delayed diagnosis and response to rituximab.

J Dtsch Dermatol Ges 2019 05 17;17(5):537-539. Epub 2019 Apr 17.

Bullous Diseases Outpatient Clinic, 2nd Department of Dermatology & Venereology, Aristotle University School of Medicine, Papageorgiou General Hospital, Thessaloniki, Greece.

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http://dx.doi.org/10.1111/ddg.13836DOI Listing
May 2019
4 Reads

Special Considerations in the Treatment of Mycosis Fungoides.

Am J Clin Dermatol 2019 Aug;20(4):571-578

Department of Dermatology and Cutaneous Biology, Sidney Kimmel College at Jefferson University Hospital, Thomas Jefferson University, 833 Chestnut Street, Suite 740, Philadelphia, PA, 19107, USA.

Mycosis fungoides is the most common form of cutaneous T cell lymphoma. Although normally presenting to physicians at an early stage and with an indolent course, mycosis fungoides can have a varied presentation. The National Comprehensive Cancer Network (NCCN) has created guidelines for the treatment and staging of mycosis fungoides. Read More

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http://dx.doi.org/10.1007/s40257-019-00431-zDOI Listing
August 2019
39 Reads

The rash that becomes an erythroderma.

Clin Dermatol 2019 Mar - Apr;37(2):88-98. Epub 2018 Dec 5.

Department of Dermatology, Venereology & Leprosy, ESI Medical College & Hospital, Bengaluru, Karnataka, India.

Erythroderma is a dermatologic emergency with potentially serious consequences. Several diseases with different etiologies characteristically appear as erythroderma. Depending on the age groups, congenital ichthyosiform disorders, infections, preexisting dermatoses, drug eruptions, and internal malignancies commonly present with, or progress to, erythroderma. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0738081X183025
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http://dx.doi.org/10.1016/j.clindermatol.2018.12.002DOI Listing
September 2019
25 Reads

Commentary: The rash from nuisance to life-threatening.

Clin Dermatol 2019 Mar - Apr;37(2):85-87. Epub 2018 Dec 5.

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http://dx.doi.org/10.1016/j.clindermatol.2018.12.001DOI Listing
September 2019
4 Reads

Erythrodermic linear IgA/IgG bullous dermatosis.

Eur J Dermatol 2019 04;29(2):220-221

Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Abeno-ku, Osaka 545-8585, Japan.

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http://dx.doi.org/10.1684/ejd.2019.3503DOI Listing
April 2019
3 Reads

A previously undescribed cutaneous paraneoplastic syndrome in a cat with thymoma.

Vet Dermatol 2019 Aug 25;30(4):342-e98. Epub 2019 Mar 25.

Department of Small Animal Teaching Hospital, The Royal (Dick) School of Veterinary Studies and The Roslin Institute, University of Edinburgh, Easter Bush, Edinburgh, EH25 9RG, Scotland, UK.

Background: Exfoliative dermatitis is a well-recognized cutaneous paraneoplastic syndrome (PNS) associated with thymoma in cats, of which the clinical and histopathological presentation has been well-characterized.

Objectives: To describe a novel clinical skin manifestation associated with thymoma in a cat.

Animal: A 14-year-old neutered female domestic short hair cat. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/vde.12745
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http://dx.doi.org/10.1111/vde.12745DOI Listing
August 2019
38 Reads

ARA-C RELATED RED EAR SYNDROME.

Ear Nose Throat J 2019 Mar 5;98(3):169-170. Epub 2019 Mar 5.

2 Department of Internal Medicine, Clinical Hematology Division, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

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http://dx.doi.org/10.1177/0145561319831270DOI Listing
March 2019
3 Reads
0.881 Impact Factor

Report: A case report on Nevirapine induced exfoliative dermatitis.

Pak J Pharm Sci 2019 Jan;32(1):221-222

Department of General Medicine, Rajiv Gandhi institute of medical sciences, Kadapa, India.

Drug induced adverse drug reactions is more common in long term therapy particularly in immune compromised patients. Most of the drugs causing dermatological reactions like skin rashes, pruritus, steven johnson syndrome and exfoliative dermatitis. Nevirapine is the first line drug for human immunodeficiency virus (HIV) infection from the category of non-nucleoside reverse transcriptase enzyme inhibitor (NNRTI). Read More

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January 2019
9 Reads
0.950 Impact Factor

Prognostic Significance of Serum Copper in Patients With Cutaneous T-cell Lymphoma.

Clin Lymphoma Myeloma Leuk 2019 04 2;19(4):228-238.e4. Epub 2019 Jan 2.

University of Arizona, Tucson, AZ.

Background: Serum copper has been reported to be increased in various cancers, including lymphoma. The purpose of the present study was to investigate the clinical and prognostic importance of serum copper levels in patients with cutaneous T-cell lymphoma (CTCL).

Patients And Methods: Serum copper was measured in 60 men and 38 women with mycosis fungoides (MF) and 14 men and 3 women with erythrodermic CTCL (6 with Sézary syndrome) consecutively evaluated from July 1980 to June 1985. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S21522650183144
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http://dx.doi.org/10.1016/j.clml.2018.12.020DOI Listing
April 2019
8 Reads