3,117 results match your criteria Erythroderma Generalized Exfoliative Dermatitis


Systematic analysis of safety profile for darunavir and its boosted agents using data mining in the FDA Adverse Event Reporting System database.

Sci Rep 2021 Jun 14;11(1):12438. Epub 2021 Jun 14.

Department of Pharmacy, Chongqing Health Center for Women and Children, Chongqing, 400021, China.

This current investigation was aimed to generate signals for adverse events (AEs) of darunavir-containing agents by data mining using the US Food and Drug Administration Adverse Event Reporting System (FAERS). All AE reports for darunavir, darunavir/ritonavir, or darunavir/cobicistat between July 2006 and December 2019 were identified. The reporting Odds Ratio (ROR), proportional reporting ratio (PRR), and Bayesian confidence propagation neural network (BCPNN) were used to detect the risk signals. Read More

View Article and Full-Text PDF

Art of prevention: Practical interventions in lip-licking dermatitis.

Int J Womens Dermatol 2020 Dec 5;6(5):377-380. Epub 2020 Jun 5.

Department of Dermatology, University of Missouri - Columbia, Columbia, MO, United States.

Dry, cracked lips are a common occurrence in both cold winter months and arid climates, leading many patients to experience discomfort year-round. Lip-licking is a compensatory measure that perpetuates the condition and often leads to lip-licking dermatitis. In patients in whom this compensatory measure becomes a chronic habit, other sequelae such as irritant contact dermatitis, cheilitis simplex, angular cheilitis, factitial cheilitis, secondary infections, and exfoliative cheilitis can arise. Read More

View Article and Full-Text PDF
December 2020

Bullous Pemphigoid Mimicking Cellulitis.

J Investig Med High Impact Case Rep 2021 Jan-Dec;9:23247096211008585

Texas Tech University Health Sciences Center, Amarillo, TX, USA.

Bullous pemphigoid (BP) is the most prevalent autoimmune blistering skin disease in the Western world affecting mainly the elderly population. The diagnosis is based on clinical assessment along with specific immunopathologic findings on skin biopsy. Risk factors include genetic factors, environmental exposures, and several infections including hepatitis B, hepatitis C, , , and cytomegalovirus. Read More

View Article and Full-Text PDF

Erythroderma (exfoliative dermatitis). Part 2: energy homeostasis and dietetic management strategies.

Clin Exp Dermatol 2021 Apr 5. Epub 2021 Apr 5.

Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK.

Erythroderma (exfoliative dermatitis) is associated with important metabolic changes that include an enhancement in energy expenditure. The key components to total energy expenditure (TEE) include basal metabolic rate (~68% of TEE), physical activity (~22% of TEE) and thermic effect of food (~10% of TEE). In the erythrodermic state, there are likely multiple contributors to the increase in basal metabolic rate, such as 'caloric drain' resulting from increased evaporation of water from enhanced transepidermal water loss, increased activity of the cardiovascular system (including high-output cardiac failure), increased nonshivering thermogenesis and hormonal changes such as hypercortisolaemia. Read More

View Article and Full-Text PDF

Exfoliative dermatitis due to dermatophytosis.

J Infect Dev Ctries 2021 Mar 7;15(2):306-309. Epub 2021 Mar 7.

Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Hasan Sadikin General Hospital, West Java, Indonesia.

Exfoliative dermatitis (ED) or erythroderma is defined as diffuse erythema and scaling of the skin involving more than 90% of the total body skin surface, which can be caused by variety of systemic and cutaneous diseases, such as infection, including dermatophytosis. Dermatophytosis is a superficial fungal infection of keratinized tissue caused by dermatophytes. There are only few case reports of ED due to dermatophytosis in literature. Read More

View Article and Full-Text PDF

Erythroderma (exfoliative dermatitis). Part 1: underlying causes, clinical presentation and pathogenesis.

Clin Exp Dermatol 2021 Feb 27. Epub 2021 Feb 27.

Department of Haematology, Tan Tock Seng Hospital, Singapore, Singapore.

Erythroderma (exfoliative dermatitis), first described by Von Hebra in 1868, manifests as a cutaneous inflammatory state, with associated skin barrier and metabolic dysfunctions. The annual incidence of erythroderma is estimated to be 1-2 per 100 000 population in Europe with a male preponderance. Erythroderma may present at birth, or may develop acutely or insidiously (due to progression of an underlying primary pathology, including malignancy). Read More

View Article and Full-Text PDF
February 2021

From SARS-CoV-2 hematogenous spreading to endothelial dysfunction: clinical-histopathological study of cutaneous signs of COVID-19.

Diagn Pathol 2021 Feb 25;16(1):16. Epub 2021 Feb 25.

Department of Clinical Medicine and Surgery, Section of Dermatology and Venereology, University of Naples Federico II, Via Pansini 5, Napoli, Italy.

Background: To date, very few studies on clinical-histopathological correlations of cutaneous disorders associated with COVID-19 have been conducted.

Case Presentation: The Case 1 was a 90-year-old man, who tested positive for SARS-CoV-2 from a nasopharyngeal swab. Two days later, he was hospitalized and after eleven days transferred to Intensive Care Unit. Read More

View Article and Full-Text PDF
February 2021

A case of erythrodermic psoriasis in which adalimumab injection sites are preserved.

Dermatol Ther 2021 03 18;34(2):e14865. Epub 2021 Feb 18.

Department of Dermatology, Istanbul Medeniyet University School of Medicine Prof. Dr. Suleyman Yalcin City Hospital, Istanbul, Turkey.

View Article and Full-Text PDF

Traditional Chinese medicine for gouty arthritis: A protocol for meta-analysis.

Medicine (Baltimore) 2021 Jan;100(3):e23699

Department of Geriatrics of the Affiliated Hospital, North Sichuan Medical College, Nanchong.

Background: Gouty arthritis (GA) is a chronic disease caused by monosodium urate crystal deposition. Repeated attacks of arthritis may lead to the deposition of urate to form gout stone, resulting in joint deformity and joint damage. Although GA is not fatal, it causes low work productivity and low quality of life. Read More

View Article and Full-Text PDF
January 2021

Diagnosing Omenn syndrome.

Pediatr Dermatol 2021 Mar 29;38(2):541-543. Epub 2021 Jan 29.

St Helens and Knowsley Teaching Hospitals NHS Trust, St Helens, UK.

Omenn syndrome is a rare combined immunodeficiency mostly associated with RAG1 and RAG2 mutations; the clinical manifestations are well-described and include neonatal erythroderma. Mortality due to opportunistic infections is a serious risk, and a timely diagnosis with a skin biopsy is an important part of the diagnostic workup. We wish to highlight key clinical features of Omenn syndrome and discuss the relevance of a skin biopsy. Read More

View Article and Full-Text PDF

A retrospective, 5-year, clinicoepidemiological study of severe cutaneous adverse reactions (SCARs).

Int J Dermatol 2021 May 17;60(5):579-588. Epub 2021 Jan 17.

Dermatology, Venereology and Leprosy, Base Hospital Delhi Cantt, Affiliated Faculty, Army College of Medical Sciences Delhi, New Delhi, India.

Background: A severe cutaneous adverse reaction (SCAR) is a rare, clinically heterogeneous, life-threatening phenomenon that results in serious skin damage, systemic complications, and significant morbidity or mortality comprising of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), or SJS-TEN overlap, acute generalized exanthematous pustulosis (AGEP), exfoliative dermatitis, and drug rash with eosinophilia and systemic symptoms (DRESS).

Materials And Methods: A retrospective study was conducted on all cases of SCARs admitted in a tertiary care referral hospital from January 2015 to December 2019. Clinical and epidemiological details were retrieved from the records of patients as per predesigned proforma. Read More

View Article and Full-Text PDF

Isolated lip dermatitis (atopic cheilitis), successfully treated with topical tacrolimus 0.03.

Med Oral Patol Oral Cir Bucal 2021 May 1;26(3):e357-e360. Epub 2021 May 1.

Oral medicine center  4 Fokaias STR, 14232, N.Ionia  Athens, Greece

Background: Exfoliative and erosive cheilitis, may be a source of speech and chewing discomfort, but may also be an aesthetic issue for the patients affected. Such a clinical presentation may implicate a variety of inflammatory conditions, including atopic (eczematous) cheilitis. Topical and systemic agents, e. Read More

View Article and Full-Text PDF

Lamotrigine induced toxic epidermal necrolysis: A case report.

Ann Med Surg (Lond) 2020 Dec 17;60:468-470. Epub 2020 Nov 17.

Department of Anaesthesiology, Institute of Medicine, Maharajgunj, Kathmandu, Nepal.

Introduction: A wide spectrum of cutaneous adverse reactions ranging from simple maculopapular rashes to more severe and life-threatening reactions like Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis(TEN) have been described after exposure to many antiepileptic drugs. Although the adverse effect following lamotrigine has been reported after a low initial dosage, the risk of developing TEN is relatively rare.

Case Report: We present a 23-year-old female, 6 months post-partum, a case of complex partial seizure, who developed TEN after 14 days of monotherapy with lamotrigine. Read More

View Article and Full-Text PDF
December 2020

Secukinumab for the treatment of SAM syndrome associated with desmoglein-1 deficiency.

Br J Dermatol 2021 04 28;184(4):770-772. Epub 2020 Dec 28.

Department of Dermatology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

View Article and Full-Text PDF

Leiner's disease (erythroderma desquamativum): A review and approach to therapy.

Dermatol Ther 2021 01 17;34(1):e14510. Epub 2020 Nov 17.

Dermatology, Pediatrics and Pathology, Rutgers University New Jersey Medical School, New Jersey Medical School, Newark, New Jersey, USA.

Leiner's disease (LD) is a rare and serious syndrome of infantile erythroderma of severe and progressive generalized seborrheic-like dermatitis, recalcitrant diarrhea, malabsorption and wasting, and recurrent local and systemic infections. The purpose of this study is to provide an updated review on management with a summarized review of available peer-reviewed articles on LD. The mechanisms underlying this disease process remain unclear. Read More

View Article and Full-Text PDF
January 2021

Pediatric drug reaction with eosinophilia and systemic symptoms: A systematic review of the literature, with a focus on relapsing cases.

Pediatr Dermatol 2021 Jan 6;38(1):125-131. Epub 2020 Nov 6.

Department of Dermatology, Hôtel-Dieu de France University Hospital, Saint-Joseph University, Beirut, Lebanon.

Background: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe cutaneous adverse drug reaction with systemic symptoms. This study aims to investigate clinical features, causative drugs, and available treatments for pediatric DRESS, particularly for relapsing cases.

Methods: A systematic search of the English and French literature on pediatric DRESS was conducted using the Medline, Embase, and Cochrane collaboration databases. Read More

View Article and Full-Text PDF
January 2021

Neonatal Erythroderma as an Early Sign of Primary Immunodeficiency.

J Pediatr 2021 03 3;230:260-261. Epub 2020 Nov 3.

Pediatric Emergency Unit, Scientific Institute for Research and Healthcare (IRCCS), Sant'Orsola University Hospital, Bologna, Italy.

View Article and Full-Text PDF

Giant Urticaria and Acral Peeling in a Child with Coronavirus Disease 2019.

J Pediatr 2021 03 21;230:261-263. Epub 2020 Oct 21.

COVID-19 Hospital, Department of Pediatrics, IRCCS Giannina Gaslini; Head of Pediatric Endocrinology, Diabetes and Metabolism, University of Genoa, Genoa, Italy.

View Article and Full-Text PDF

Equine Idiopathic Systemic Granulomatous Disease With Manifestation in the Cerebellum Associated With Equid Gammaherpesvirus 2.

J Equine Vet Sci 2020 11 15;94:103225. Epub 2020 Aug 15.

Department of Pathology, University of Veterinary Medicine, Hannover, Foundation, Hannover, Germany.

Idiopathic systemic granulomatous disease (ISGD), also known as equine sarcoidosis is an uncommon disease of horses, manifesting in exfoliative dermatitis and granulomatous inflammation in various organs. The current report presents a case of a 15-year-old Hanoverian mare with a 4-month history of weight loss, recurrent fever, skin lesions, and movement disorders. Pathological examination revealed granulomatous and necrotizing inflammation in the skin, regional lymph nodes, and cerebellum. Read More

View Article and Full-Text PDF
November 2020

The significance of dermoscopy and trichoscopy in differentiation of erythroderma due to various dermatological disorders.

J Eur Acad Dermatol Venereol 2021 Jan 8;35(1):230-240. Epub 2020 Dec 8.

Department of Dermatology, Medical University of Warsaw, Warsaw, Poland.

Background: The diagnosis of a patient with erythroderma may be difficult and sometimes pose a challenge for both dermatologist and pathologist. The role of dermoscopy in this area seems to be poorly investigated. There are only a few reports, with limited number of patients, describing dermoscopic features in erythroderma of various origins. Read More

View Article and Full-Text PDF
January 2021

Trimetazidine, a hitherto unreported cause of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome.

Contact Dermatitis 2021 Mar 26;84(3):208-210. Epub 2020 Oct 26.

Department of Dermatology, Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital, New Delhi, India.

View Article and Full-Text PDF

Erythroderma: A clinicopathological study of 47 cases from 2018 to 2020.

Dermatol Ther 2020 11 10;33(6):e14342. Epub 2020 Oct 10.

Department of Dermatology and Venereology, Cerrahpaşa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey.

Erythroderma, or exfoliative dermatitis, is an inflammatory disorder characterized by erythema and scaling, affecting most of the skin surface. It may be a result of many different causes such as previous dermatoses (psoriasis, eczema, atopic dermatitis [AD], pityriasis rubra pilaris, and pemphigus foliaceous), drug reactions, malignancies (mycosis fungoides [MF], Sézary syndrome, adult T cell leukemia/lymphoma), infections, and idiopathic disorders. Regardless of the etiology, the clinical appearance of erythroderma is similar in all patients. Read More

View Article and Full-Text PDF
November 2020

Characterizing Disease Features and Other Medical Diagnoses in Patients With Pityriasis Rubra Pilaris.

JAMA Dermatol 2020 12;156(12):1373-1374

Department of Dermatology, University of Chicago Pritzker School of Medicine, Chicago, Illinois.

View Article and Full-Text PDF
December 2020

A Ten-Year-Old Boy with Antiepileptic Drugs-Induced DRESS Syndrome.

Case Rep Pediatr 2020 11;2020:8837607. Epub 2020 Sep 11.

Teaching Hospital Karapitiya, Galle, Sri Lanka.

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a life-threatening adverse drug reaction if it is not timely diagnosed and treated. This happens probably following a cascade of immune reactions after the administration of the drug ultimately leading to multiorgan failure and death. Several groups of drugs have been identified as potential aetiologies but the commonest one identified is antiepileptic drugs. Read More

View Article and Full-Text PDF
September 2020

Disseminated vegetating infantile bromoderma: A dramatic response to systemic steroids.

Dermatol Ther 2020 11 20;33(6):e14298. Epub 2020 Sep 20.

Department of Dermatology, Venereology, and Andrology, Faculty of Medicine, Tanta University, Tanta, Egypt.

Bromoderma is a rare hypersensitivity reaction caused by bromide intake. It was relatively frequent in the early years of the previous century because of the common use of bromide-containing solutions in pediatrics due to their antispasmodic, expectorant, sedative, and anticonvulsant effects. Although recently prohibited in many countries, bromides are still used as an adjuvant anticonvulsant drug and still present in some over the counter antispasmodics and analgesics. Read More

View Article and Full-Text PDF
November 2020

Treatment of psoriatic erythroderma using systemic corticosteroids: A timeless option?

Dermatol Ther 2020 11 22;33(6):e14222. Epub 2020 Sep 22.

Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.

View Article and Full-Text PDF
November 2020

Acral skin eruption observed during SARS-CoV-2 pandemic: possible keratolysis exfoliativa with red palms and soles.

J Eur Acad Dermatol Venereol 2020 Dec 10;34(12):e783-e785. Epub 2020 Sep 10.

Division of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

View Article and Full-Text PDF
December 2020

A novel SPINK5 mutation and successful subcutaneous immunoglobulin replacement therapy in a child with Netherton syndrome.

Pediatr Dermatol 2020 Nov 7;37(6):1202-1204. Epub 2020 Aug 7.

Department of Paediatrics, Centre for Primary Immunodeficiencies, Jessenius Faculty of Medicine of Comenius University in Bratislava, University Hospital in Martin, Martin, Slovakia.

We report a 2-year-old patient with Netherton syndrome presenting with generalized exfoliative erythroderma, ichthyosiform dermatitis, trichorrhexis invaginata, hypernatremic dehydration, failure to thrive, and recurrent respiratory infections. Molecular analysis of SPINK5 identified a novel mutation (c.1530CA). Read More

View Article and Full-Text PDF
November 2020

Hydroxychloroquine-induced erythroderma: A rare adverse effect of a commonly used drug.

Dermatol Ther 2020 11 8;33(6):e14145. Epub 2020 Sep 8.

Department of Dermatology, ABVIMS, Dr RML Hospital, New Delhi, India.

View Article and Full-Text PDF
November 2020

NRF2 Augments Epidermal Antioxidant Defenses and Promotes Atopy.

J Immunol 2020 08 20;205(4):907-914. Epub 2020 Jul 20.

Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.

Atopic dermatitis is a chronic form of allergic contact dermatitis that is closely associated with a compromised epidermal barrier. Immunogenicity of a given electrophilic hapten after penetration of this barrier depends directly on biochemical reactions in the thiol-rich layer in the stratum granulosum. In response to electrophilic hapten, NF-erythroid 2-related factor 2 (NRF2) in keratinocytes efficiently induces the production of antioxidants. Read More

View Article and Full-Text PDF