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    1 OF 86

    Leprosy Presenting with Iridocyclitis: A Diagnostic Dilemma.
    J Ophthalmic Vis Res 2017 Oct-Dec;12(4):437-439
    Department of Pathology, Uttar Pradesh University of Medical Sciences (U.P.U.M.S.), Saifai, Etawah, India.
    Purpose: To report a case of lepromatous iridocyclitis that posed a diagnostic challenge.

    Case Report: A 50-yeasr-old male developed profound loss of vision in the right eye, while he was in the hospital with septicemia presenting with fever, dysuria, and abdominal swelling. He also developed erythema nodosum on the legs. Read More

    Clinico-pathological features of erythema nodosum leprosum: A case-control study at ALERT hospital, Ethiopia.
    PLoS Negl Trop Dis 2017 Oct 13;11(10):e0006011. Epub 2017 Oct 13.
    London School of Hygiene and Tropical Medicine (LSHTM), London, United Kingdom.
    Background: Leprosy reactions are a significant cause of morbidity in leprosy population. Erythema nodosum leprosum (ENL) is an immunological complication affecting approximately 50% of patients with lepromatous leprosy (LL) and 10% of borderline lepromatous (BL) leprosy. ENL is associated with clinical features such as skin lesions, neuritis, arthritis, dactylitis, eye inflammation, osteitis, orchitis, lymphadenitis and nephritis. Read More

    Case Report: Histoplasmosis in Himachal Pradesh (India): An Emerging Endemic Focus.
    Am J Trop Med Hyg 2017 Sep 25. Epub 2017 Sep 25.
    Department of Microbiology, Dr. R. P. Govt. Medical College, Kangra (Tanda), Himachal Pradesh, India.
    We describe four cases of histoplasmosis indigenous to Himachal Pradesh (India) that will be of considerable public health interest. A 48-year-old human immunodeficiency virus (HIV)-negative man with cervical and mediastinal lymphadenopathy, hepatosplenomegaly, adrenal mass, and bone marrow involvement was treated as disseminated tuberculosis without benefit. Progressive disseminated histoplasmosis was diagnosed from the fungus in smears from adrenal mass. Read More

    Skin Manifestations Associated with Autoimmune Liver Diseases: a Systematic Review.
    Clin Rev Allergy Immunol 2017 Oct 9. Epub 2017 Oct 9.
    Dermatologia Ente Ospedaliero Cantonale, Ospedale Regionale Bellinzona e Valli, Bellinzona, Switzerland.
    Autoimmune liver diseases, which include mainly autoimmune hepatitis, primary biliary cholangitis, primary sclerosing cholangitis, and the variant syndromes, are often associated with extrahepatic autoimmune diseases. However, the association with cutaneous diseases is less well described. In the present article, we provide a systematic literature review on skin manifestations linked to each of these four autoimmune liver diseases, excluding skin manifestations of systemic diseases. Read More

    Unilateral plantar erythema nodosum in sarcoidosis.
    Arthritis Rheumatol 2017 Oct 9. Epub 2017 Oct 9.
    Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Ulmenweg 18, 91054, Erlangen, Germany.
    A 32-year old male Caucasian patient presented with mild exertional dyspnea, pain and swelling of both ankles, and general malaise. On examination symmetrical arthritis of both ankles and a vivid nodular erythema with slight pain on pressure was detected on the sole of the right foot (A). A therapy with ibuprofen had not led to any improvement of symptoms. Read More

    T-cell regulation in Erythema Nodosum Leprosum.
    PLoS Negl Trop Dis 2017 Oct 9;11(10):e0006001. Epub 2017 Oct 9.
    London School of Hygiene and Tropical Medicine (LSHTM), Faculty of Infectious Tropical Diseases, London, United Kingdom.
    Leprosy is a disease caused by Mycobacterium leprae where the clinical spectrum correlates with the patient immune response. Erythema Nodosum Leprosum (ENL) is an immune-mediated inflammatory complication, which causes significant morbidity in affected leprosy patients. The underlying cause of ENL is not conclusively known. Read More

    Aneurysm formation after stent grafting in vascular Behcet's Disease.
    Arthritis Rheumatol 2017 Oct 3. Epub 2017 Oct 3.
    Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
    A 40-year-old man with a history of oral and ileocecal ulcers, acneiform lesions, erythema nodosum and deep vein thrombosis presented with fever, abdominal pain and a pulsatile mass in the right groin. Two months prior to the presentation, he underwent stent grafting via the right femoral artery for an abdominal aortic aneurysm. Enhanced computed tomography disclosed aneurysms at the both ends of the stent (blue and green arrows in the panels A and B) and at the right femoral puncture site (blue arrowhead). Read More

    Azathioprine in Chronic Recalcitrant Erythema Nodosum Leprosum: A Case Report.
    J Clin Diagn Res 2017 Aug 1;11(8):FD01-FD02. Epub 2017 Aug 1.
    Professor, Department of Pharmacology, Regional Institute of Medical Sciences, Imphal, Manipur, India.
    Erythema Nodosum Leprosum (ENL) may have a chronic course which may be recalcitrant to treatment. Preferred treatment modalities are systemic corticosteroids and thalidomide. Azathioprine, methotrexate and cyclosporine are immunosuppressants which may also be used as a steroid sparing agent. Read More

    New Insight into the Pathogenesis of Erythema Nodosum Leprosum: The Role of Activated Memory T-Cells.
    Front Immunol 2017 15;8:1149. Epub 2017 Sep 15.
    London School of Hygiene and Tropical Medicine, Faculty of Infectious Diseases, London, United Kingdom.
    Memory T-cells, particularly, effector memory T cells are implicated in the pathogenesis of inflammatory diseases and may contribute to tissue injury and disease progression. Although erythema nodosum leprosum (ENL) is an inflammatory complication of leprosy, the role of memory T cell subsets has never been studied in this patient group. The aim of this study was at investigate the kinetics of memory T cell subsets in patients with ENL before and after prednisolone treatment. Read More

    [Giardia duodenalis and its involvement in skin diseases].
    Ann Dermatol Venereol 2017 Nov 29;144(11):676-684. Epub 2017 Sep 29.
    Fondation Cheikh Khalifa Mohammed VI, Casablanca, Maroc; Faculté de médecine et de pharmacie, université Hassan II, Casablanca, Maroc.
    Backgound: Over the last thirty years, the scientific community has become increasingly interested in the intestinal flora, whether commensal or pathogenic, and its impact on other organs. In dermatology, the correlation between intestinal microbial agents and cutaneous lesions is well established. Giardia duodenalis, an intestinal parasite, has been particularly widely studied. Read More

    Takayasu arteritis presented with acute heart failure: case report and review of literature.
    ESC Heart Fail 2017 Sep 28. Epub 2017 Sep 28.
    Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
    Acute heart failure due to myocarditis is not common in Takayasu arteritis, let alone in combination with thrombosis affecting both ventricles and pulmonary arteries. The concomitant infection of non-tuberculosis mycobacterium further complicates the clinical scenario and poses challenges for implementation of tailored treatments. This case report describes a teenage girl with a history of intermittent claudication and Erythema Nodosum who developed acute heart failure. Read More

    Etanercept in erythema nodosum leprosum.
    An Bras Dermatol 2017 Jul-Aug;92(4):575-577
    Professor Rubem David Azulay Dermatology Institute, Santa Casa de Misericórdia do Rio de Janeiro (DPRDA-SCMRJ) - Rio de Janeiro (RJ), Brazil.
    One of the biggest challenges in treating leprosy is the control of reaction events. Patients with lepromatous leprosy may present reaction type II, or erythema nodosum leprosum, during treatment, and this reaction can remain in a recurrent form after being released from the hospital, requiring the use of thalidomide and/or prednisone for long periods of time, in turn increasing the risk of side effects. Two reports of the use of antiTNF to treat erythema nodosum leprosum were found in the literature. Read More

    A case of leprosy, erythema nodosum leprosum, and hemophagocytic syndrome: A continuum of manifestations of same agent-host interactions.
    Intractable Rare Dis Res 2017 Aug;6(3):230-233
    Department of Medicine, All India Institute of Medical Sciences, Delhi, India.
    A young adult man with 4-years history of lepromatous leprosy (received irregularly multidrug therapy) presented with two and half years history of symptoms suggestive of chronic erythema nodosum leprosum (ENL), initially responded to steroids and thalidomide, but later on failed. During the last 2-months, he developed fever, vomiting, and subsequently altered sensorium. On evaluation, he had hepatosplenomegaly, hyponatremia, hyperferritinemia, hemophagocytosis in bone marrow aspiration, lobular panniculitis in skin biopsy, and multiple parenchymal nodules in chest imaging. Read More

    Erythema nodosum-like panniculitis mimicking disease recurrence: A novel toxicity from immune checkpoint blockade therapy-Report of 2 patients.
    J Cutan Pathol 2017 Sep 13. Epub 2017 Sep 13.
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
    Immunotherapies targeting cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and the programmed cell death 1 (PD-1) receptor and its ligand (PD-L1) have showed substantial therapeutic benefit in patients with clinically advanced solid malignancies. However, autoimmune toxicities are common and often significant adverse events with these agents. While rash and pruritus remain the most common cutaneous complications in treated patients, novel dermatologic toxicities related to immune checkpoint blockade continue to emerge as the number of patients exposed to immunotherapy increases. Read More

    Simultaneous analysis of multiple T helper subsets in leprosy reveals distinct patterns of Th1, Th2, Th17 and Tregs markers expression in clinical forms and reactional events.
    Med Microbiol Immunol 2017 Dec 5;206(6):429-439. Epub 2017 Sep 5.
    Centro de Ciências da Saúde, Universidade do Sagrado Coração, Rua Irmã Arminda, 10-50, Jardim Brasil, Bauru, São Paulo, 17.011-160, Brazil.
    Leprosy is a chronic infectious disease caused by Mycobacterium leprae. Previous studies have demonstrated that the difference among clinical forms of leprosy can be associated with the immune response of patients, mainly by T helper (Th) and regulatory T cells (Tregs). Then, aiming at clarifying the immune response, the expression of cytokines related to Th1, Th2, Th17 and Tregs profiles were evaluated by qPCR in 87 skin biopsies from leprosy patients. Read More

    Behçet's syndrome: providing integrated care.
    J Multidiscip Healthc 2017 14;10:309-319. Epub 2017 Aug 14.
    Division of Rheumatology, Department of Internal Medicine.
    Behçet's syndrome (BS) is a multisystem vasculitis that presents with a variety of mucocutaneous manifestations such as oral and genital ulcers, papulopustular lesions and erythema nodosum as well as ocular, vascular, gastrointestinal and nervous system involvement. Although it occurs worldwide, it is especially prevalent in the Far East and around the Mediterranean Sea. Male gender and younger age at disease onset are associated with a more severe disease course. Read More

    A case of Q fever with erythema nodosum.
    Infection 2017 Aug 17. Epub 2017 Aug 17.
    Department of Internal Medicine, Centre hospitalier universitaire de Poitiers, 2 Rue de la milétrie, 86000, Poitiers, France.
    Background: Acute Q fever is asymptomatic in 60% of the patients, while the reminder may present with fever, pneumoniae, and hepatitis. Skin manifestations are uncommon including transient punctiform rashes, purpuric, or maculopapular eruptions. Erythema nodosum have seldom been reported. Read More

    I Can Not Wear My Sunglasses: An Unusual Sarcoidosis Presentation.
    Korean J Fam Med 2017 Jul 20;38(4):226-228. Epub 2017 Jul 20.
    Department of Internal Medicine Unit, University Hospital Salamanca, Salamanca, Spain.
    A 39-year-old Caucasian man was referred to University Hospital Salamanca from a primary care unit due to the presence of an erythematous violaceous nodule at the superior portion of his nose. Physical examination indicated that the firm, fixed erythematous violaceous nodule measured approximately 2 cm in diameter and was located inferior to a scar on the nasal bridge. Cutaneous involvement in sarcoidosis occurs in 25% of cases. Read More

    Environmental sensitivity as a trigger of erythema nodosum and perimenopausal symptoms.
    BMJ Case Rep 2017 Aug 1;2017. Epub 2017 Aug 1.
    University of Arizona Center for Integrative Medicine, University of Arizona College of Medicine, Tucson, Arizona, USA.
    A 45-year-old woman presented to the University of Arizona Integrative Medicine Clinic for advice on managing recurrent erythema nodosum (EN), along with recent onset perimenopausal symptoms. Her painful EN flares had occurred two to six times per year over the past 14 years, yet had attenuated over the past 5 years until recently, and she presented with bilateral EN lesions on the shins. An environmental exposure history revealed that a new plastic-containing water pot had been introduced at her office just prior to her latest EN flare. Read More

    Bullous Erythema Nodosum Leprosum as the First Manifestation of Multibacillary Leprosy: A Rare Phenomenon.
    Am J Dermatopathol 2017 Nov;39(11):857-859
    Departments of *Histopathology, and †Dermatology, Sir Ganga Ram Hospital, Rajender Nagar, New Delhi, India.
    Erythema nodosum leprosum (ENL) may uncommonly present before treatment in patients with multibacillary leprosy. Atypical manifestations are known in ENL and may be clinically misleading. Such wide variations in the clinical presentation of leprosy in reaction make histopathology an important tool for supporting clinical diagnosis. Read More

    Erythema nodosum masking nephrogenic systemic fibrosis as initial skin manifestation.
    BMC Nephrol 2017 Jul 24;18(1):249. Epub 2017 Jul 24.
    Unit of Nephrology, Department of Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
    Background: Nephrogenic systemic fibrosis (NSF) is a complication of the gadolinium-based contrast agent used in imaging studies. It is typically characterised by hard, erythematous and indurated skin plaques with surrounding subcutaneous oedema. Distinct papules and subcutaneous nodules can also be seen. Read More

    A case of severe erythema nodosum induced by methimazole.
    Saudi Pharm J 2017 Jul 12;25(5):813-815. Epub 2016 Nov 12.
    Yildirim Beyazit University, Ataturk Training and Research Hospital, Dermatology Clinic, Ankara, Turkey.
    Erythema nodosum (EN), is the most common variant of septal panniculitis and is possibly a delayed hypersensitivity reaction triggered by a wide range of antigenic stimuli. Hypersensitivity reactions due to medications have been recognized as a cause of 3-10% of EN cases. Case reports of EN associated with the anti-thyroid drugs are quite rarely reported in the literature even if there is a common use of anti-thyroid drugs. Read More

    Multidisciplinary approach and long-term follow-up in a series of 640 consecutive patients with sarcoidosis: Cohort study of a 40-year clinical experience at a tertiary referral center in Barcelona, Spain.
    Medicine (Baltimore) 2017 Jul;96(29):e7595
    aDepartment of Internal Medicine bDepartment of Dermatology cDepartment of Pulmonary dDepartment of Pathology eDepartment of Ophthalmology fDepartment of Neurology gDepartment of PET Unit-Institut de Diagnòstic per la Imatge hUniversity of Barcelona iFaculty of Medicine and Health Sciences, Universitat Internacional de Catalunya jBellvitge University Hospital, Bellvitge Biomedical Research Institute-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
    Cohort studies of large series of patients with sarcoidosis over a long period of time are scarce. The aim of this study is to report a 40-year clinical experience of a large series of patients at Bellvitge University Hospital, a tertiary university hospital in Barcelona, Spain. Diagnosis of sarcoidosis required histological confirmation except in certain specific situations. Read More

    Therapeutic Dilemma of Refractory Erythema Nodosum Leprosum.
    Am J Trop Med Hyg 2017 Jun;96(6):1362-1364
    Department of Leprosy, Shanghai Dermatology Hospital, Shanghai, People's Republic of China.
    AbstractErythema nodosum leprosum (ENL), also known as type II leprosy reaction, is a severe immune-mediated complication of multibacillary leprosy. For ENL, corticosteroids and thalidomide are the mainstays of treatment. Other immunosuppressants, such as clofazimine, cyclosporine, and azathioprine have also been used. Read More

    A leprosy clinical severity scale for erythema nodosum leprosum: An international, multicentre validation study of the ENLIST ENL Severity Scale.
    PLoS Negl Trop Dis 2017 Jul 3;11(7):e0005716. Epub 2017 Jul 3.
    Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.
    Objectives: We wished to validate our recently devised 16-item ENLIST ENL Severity Scale, a clinical tool for measuring the severity of the serious leprosy associated complication of erythema nodosum leprosum (ENL). We also wished to assess the responsiveness of the ENLIST ENL Severity Scale in detecting clinical change in patients with ENL.

    Methods: Participants, recruited from seven centres in six leprosy endemic countries, were assessed using the ENLIST ENL Severity Scale by two researchers, one of whom categorised the severity of ENL. Read More

    Serum macrophage migration inhibitory factor levels in leprosy patients with erythema nodosum leprosum.
    Indian J Dermatol Venereol Leprol 2017 Jun 27. Epub 2017 Jun 27.
    Department of Immunopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
    Background: Erythema nodosum leprosum is an immune-mediated complication of leprosy which causes significant morbidity. Biomarkers in the pathogenesis of erythema nodosum leprosum are not yet fully determined.

    Aim: To determine macrophage migration inhibitory factor levels in the sera of leprosy patients with erythema nodosum leprosum and to correlate the same with clinical parameters. Read More

    Skin Manifestations of Inflammatory Bowel Disease.
    Clin Rev Allergy Immunol 2017 Jun 23. Epub 2017 Jun 23.
    Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
    Inflammatory bowel disease (IBD) with its two main subtypes Crohn's disease and ulcerative colitis is not restricted to the gastrointestinal tract. Indeed, so-called extraintestinal manifestations (EIMs) are frequent and considerably affect morbidity and mortality. The prevalence of EIMs ranges from 6 to 47%. Read More

    Adalimumab-Responsive Refractory Sarcoidosis Following Multiple Eyebrow Tattoos: A Case Report.
    Tanaffos 2017 ;16(1):80-83
    Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Tehran Iran.
    Sarcoidosis is a granulomatous disease that can involve multiple organs including the lungs, eyes, nerves, and skin. Cosmetic tattooing can be a predisposing factor for sarcoidosis, and its incidence is likely to increase along with its popularity. A 47-year-old woman with symptoms of fever and polyarthritis along with erythema nodosum lesions on the legs, swollen eyebrows, and a history of multiple eyebrow tattooing was referred to our center. Read More

    Examination of the Microbial Spectrum in the Etiology of Erythema Nodosum: A Retrospective Descriptive Study.
    J Immunol Res 2017 28;2017:8139591. Epub 2017 May 28.
    Department of Dermatology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.
    Even though infections are the most common cause of erythema nodosum (EN), only certain microorganisms take the great interest such as streptococci in knowledge. Our aim was to examine the frequency and type of infections in EN, to determine the characteristics of patients with an infectious etiology, and to discuss the role of these microbes in EN pathology in the context of their interactions with humans. Charts of 81 patients with EN who were seen between 2003 and 2017 were retrospectively reviewed. Read More

    [Behçet's disease: Intracardiac thrombosis (a description of two cases and a review of literature)].
    Ter Arkh 2017;89(5):79-82
    V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia.
    Behçet's disease (BD) is systemic vasculitis of unknown etiology, which is more common in the countries located along the Great Silk Road. The disease is diagnosed if a patient has 4 key diagnostic signs: aphthous stomatitis, genital sores, and eye and skin lesions. Vascular diseases referred to as minor criteria for BD are characterized by the formation of aneurysms and thrombosis, predominantly in the venous bed. Read More

    Role of S-100 Immunostain as An Auxiliary Diagnostic Aid in Leprosy.
    JNMA J Nepal Med Assoc 2017 Jan-Mar;56(205):141-144
    Department of Diagnostic Pathology, Kobe University Graduate School of Medicine, Kobe, Japan.
    Introduction: Histopathologic diagnosis of leprosy is difficult when Bacillary Index (BI) is zero and neural involvement are not easily identifiable on routine Hematoxylin and Eosin stain. This study was undertaken to study the role of S-100 immunostaining in demonstrating different patterns of nerve involvement in various types of leprosy.

    Methods: Thirty one skin biopsies with clinico-histopathologic diagnoses of leprosy over a period of two years were included in the study. Read More

    Lysinibacillus massiliensis Panniculitis Masquerading as Erythema Nodosum: A Case Report.
    Open Forum Infect Dis 2017 6;4(2):ofx072. Epub 2017 Apr 6.
    Infectious Diseases.
    Lysinibacillus massiliensis, formerly Bacillus massiliensis, is an environmental Gram-positive bacillus that is generally non-pathogenic. Rare case reports in immunosuppressed patients have described sepsis with this organism. In this study, we report a case of L massiliensis as a cause of infectious panniculitis mimicking erythema nodosum after infusion of autologous adipose-derived stem cells in an immunosuppressed patient with refractory Crohn's disease. Read More

    Efficacy of cytapheresis for remission induction and dermatological manifestations of ulcerative colitis.
    J Clin Apher 2017 Jun 5. Epub 2017 Jun 5.
    Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan.
    Background: In ulcerative colitis (UC) patients, cytapheresis depletes elevated and activated leucocytes, which are known to release inflammatory cytokines including tumor necrosis factor (TNF)-α. Further, there are UC patients who develop erythema nodosum (EN) or pyoderma gangrenosum (PG) as extra-intestinal manifestations of UC.

    Methods: Between 2008 and 2015, 181 consecutive patients with active UC received cytapheresis with either a granulocyte and monocyte apheresis (GMA) column or with a leucocyte removal filter (LCAP) as remission induction therapy. Read More

    [Evidence of compression therapy].
    Hautarzt 2017 Aug;68(8):625-631
    Klinik- und Poliklinik für Haut- und Geschlechtskrankheiten, Universitätsmedizin Greifswald, F.-Sauerbruchstr., 17475, Greifswald, Deutschland.
    Background: Medical compression therapy is widely used to treat phlebologic diseases. Compression bandages as well as compression stockings are used. Compression has been identified to be an effective conservative therapy for the healing of venous ulcers and other indications. Read More

    A Mini-Review on Thalidomide: Chemistry, Mechanisms of Action, Therapeutic Potential and Anti-Angiogenic Properties in Multiple Myeloma.
    Curr Med Chem 2017 ;24(25):2736-2744
    Department of Pharmacy- Drug Sciences, University of Bari "A. Moro", Bari. Italy.
    Thalidomide is a drug with interesting therapeutic properties but also with severe side effects which require a careful and monitored use. Potential immunomodulatory, antiinflammatory, anti-angiogenic and sedative properties make thalidomide a good candidate for the treatment of several diseases such as multiple myeloma. Through an increase in the degradation of TNFα-mRNA, thalidomide reduces the production of TNFα by monocytes and macrophages stimulated by lipopolysaccharide or by T lymphocytes induced by mitogenic stimuli. Read More

    [Erythema nodosum as a reaction pattern: a broad spectrum of underlying causes].
    Ned Tijdschr Geneeskd 2017 ;161(0):D1061
    Franciscus Gasthuis, Rotterdam.
    Erythema nodosum is a skin disorder that is characterised by the presence of painful erythematous nodules and plaques, mainly located on the shins. This disorder is associated with comorbidities and can be considered as an aspecific reaction pattern to a broad range of causes. However, an idiopathic variant also exists, which occurs in 22-72% of cases. Read More

    Cutaneous Manifestations of Medium- and Large-Vessel Vasculitis.
    Clin Rev Allergy Immunol 2017 May 26. Epub 2017 May 26.
    Université Pierre et Marie Curie-Paris VI, Assistance Publique-Hôpitaux de Paris, Service de Dermatologie-Allergologie, Hôpital Tenon, 4 rue de la Chine, 75020, Paris, France.
    Dermatologic manifestations are observed in almost all systemic vasculitides, even in large-and medium-vessel vasculitides, although such vessels are not found in the skin. Cutaneous manifestations may be related to a direct skin localization of the systemic vasculitis or a non-specific process associated with the vasculitis. According to the 2012 International Chapel Hill consensus, the two major variants of large-vessel vasculitides are Takayasu arteritis and giant-cell arteritis. Read More

    Case Report: Behçet's disease accompanied with vitiligo.
    F1000Res 2017 23;6:310. Epub 2017 Mar 23.
    Dermatology Department, Kayseri Training and Research Hospital, Kayseri, 38050, Turkey.
    Recently, a few case reports and clinical studies have been published that explore the association of Behçet's Disease (BD) and vitiligo, with conflicting results. Genetic and immunological properties of BD and presence of autoantibodies support autoimmunity, but clinical features suggest autoinflammatory diseases. BD is thought to be a cornerstone between autoimmune and autoinflammatory diseases. Read More

    Thalidomide induced deep venous thrombosis in a case of steroid dependent erythema nodosum leprosum- a management conundrum.
    Curr Drug Saf 2017 May 18. Epub 2017 May 18.
    Department of General Medicine, Institute Of Medical Sciences, Banaras Hindu University, Varanasi-221005. India.
    Thalidomide, previously banned owing to the issues of teratogenicity is being used and tested for a variety of dermatological and non dermatological conditions. The drug has been approved for the management of ENL and Multiple myeloma. The drug is commonly known to produce adverse effects like peripheral neuropathy and constipation. Read More

    In Situ complement activation and T-cell immunity in leprosy spectrum: An immunohistological study on leprosy lesional skin.
    PLoS One 2017 15;12(5):e0177815. Epub 2017 May 15.
    Department of Clinical Immunology, Colleges of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom.
    Mycobacterium leprae (M. leprae) infection causes nerve damage and the condition worsens often during and long after treatment. Clearance of bacterial antigens including lipoarabinomannan (LAM) during and after treatment in leprosy patients is slow. Read More

    [Musculoskeletal manifestations of sarcoidosis].
    Z Rheumatol 2017 Jun;76(5):408-414
    Poliklinik, Funktionsbereich und Hiller Forschungszentrum für Rheumatologie, Universitätsklinikum der Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Deutschland.
    Musculoskeletal manifestations in the context of sarcoidosis are frequently observed. The rheumatologist regularly encounters this disease in clinical practice. In the present review, we aim to give a current overview of the manifestations and treatments relevant to the practicing rheumatologist. Read More

    A Rare Cause of Portal Hypertension: Behcet's Disease and Nodular Regenerative Hyperplasia of the Liver.
    Cureus 2017 Mar 29;9(3):e1125. Epub 2017 Mar 29.
    Gastroenterology, PVS Institute of Digestive Diseases, PVS Memorial Hospital.
    Nodular regenerative hyperplasia (NRH) is a rare liver condition in which widespread benign transformation of the hepatic parenchyma into small regenerative nodules occur, leading to development of non-cirrhotic portal hypertension. Conditions associated with NRH include rheumatologic, hematological, autoimmune, infectious, neoplastic, or drug-related etiology. Accurate diagnosis is made on liver biopsy, showing diffuse micronodular transformation in the absence of fibrosis. Read More

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