Search Our Scientific Publications & Authors

Turk J Med Sci 2019 Apr 18;49(2):624-634. Epub 2019 Apr 18.

Background/aim: Erythema nodosum (EN) is an inflammatory disorder of subcutaneous tissue. Although etiopathogenesis of the disease is unknown, many predisposing factors such as infections, systemic disease, and drugs have been identified. Neutrophil to lymphocyte ratio (NLR) has been shown to be a novel inflammatory marker in many dermatological diseases. Read More

Rev Soc Bras Med Trop 2019 Apr 11;52:e20180385. Epub 2019 Apr 11.

Departamento de Farmácia Social, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.

Introduction: Thalidomide, used to treat erythema nodosum leprosum (ENL), is associated with severe adverse events (AEs) and is highly teratogenic.

Methods: A cross-sectional study was conducted on thalidomide-treated patients with ENL. AEs and selected variables were investigated through interviews and assessment of medical records. Read More

Brain Nerve 2019 Apr;71(4):345-349

Department of Dermatology, Kansai Medical University.

Cutaneous lesions of sarcoidosis show varied clinical features. They are categorized into specific types; skin sarcoid, scar infiltrations with granulomas and foreign bodies, and non-specific lesions like erythema nodosum. Identification of the cutaneous lesions is important for the diagnosis of sarcoidosis, because they are an easily accessible source of tissue for histologic examination. Read More

Brain Nerve 2019 Apr;71(4):329-333

Department of Dermatology, Saitama Medical University.

Behçet disease is an inflammatory disease of unknown etiology that affects various organs, such as the skin, eye, central nervous system, and blood vessels. Mucocutaneous manifestations are characterized by oral ulcers, genital ulcers, erythema nodosum, papulopustular eruptions, and thrombophlebitis. The diagnosis is based on the diagnostic criteria defined by the Japanese Ministry of Health, Labour and Welfare. Read More

Rheumatol Int 2019 Apr 11. Epub 2019 Apr 11.

Department of Pediatric Rheumatology, National Research Center of Mother and Child Health, University Medical Center, Astana, Kazakhstan.

Behçet's disease (BD) is a systemic vasculitis affecting prominently the veins, which is usually diagnosed in adulthood, but can occur in children younger than 16 years in about 4-26% of cases. The therapy is based on several immune-suppressive drugs; in case of inadequate control and/or complications, the biologic therapy with anti-TNF drugs has been successfully used in adults. Here, we reported one pediatric case of BD with systemic (persistent/recurrent high fever), skin and mucosal manifestations (recurrent aphthous stomatitis, anal/penile ulcers, erythema nodosum and papulo-pustules), that were unresponsive to the conventional treatment with steroids and colchicine; however, he was successfully treated with adalimumab. Read More

Yonago Acta Med 2019 Mar 28;62(1):159-162. Epub 2019 Mar 28.

Division of Child Neurology, Department of Brain and Neurosciences, School of Medicine, Tottori University Faculty of Medicine, Yonago 683-8504, Japan.

We report the case of a 6-year-old male who developed recurrent erythema nodosum (EN) at the age of 3 years. The patient exhibited hypertelorism, low-set ears, micrognathia, moderate intellectual disability, thin long fingers, loose anagen hair, and prominent palmoplantar wrinkles. A heterozygous single nucleotide variant in the gene (c. Read More

Semin Arthritis Rheum 2019 Mar 9. Epub 2019 Mar 9.

DOIM-Rheum, MSC 10 5550, University of New Mexico Health Sciences Center, 5th FL ACC, Albuquerque, NM 87131, United States.

Objective: The goal of this study was to determine the characteristics of Behçet's disease (BD) in the American Southwest.

Material And Methods: This was a cross-sectional study of BD patients clinically encountered during a 2-year period. All subjects fulfilled the International Study Group criteria (ISG) or International Criteria for Behcet's Disease (ICBD). Read More

Front Immunol 2019 19;10:495. Epub 2019 Mar 19.

Leprosy Laboratory, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil.

Leprosy is an infectious disease caused by the intracellular bacillus that mainly affects the skin and peripheral nerves. One of the most intriguing aspects of leprosy is the diversity of its clinical forms. Paucibacillary patients are characterized as having less than five skin lesions and rare bacilli while the lesions in multibacillary patients are disseminated with voluminous bacilli. Read More

Clin Nucl Med 2019 Mar 29. Epub 2019 Mar 29.

From the Department of Nuclear Medicine and PET, Mahatma Gandhi Medical College & Hospital, Jaipur, Rajasthan, India.

The present article presented a 47-year-old woman with areas of nodular swelling and discoloration involving bilateral lower limbs since 12 months. Biopsy from skin lesions revealed erythema nodosum. As erythema nodosum can be secondary to multiple etiologies, whole-body F-FDG PET/CT was performed to assess the disease distribution and guide the site of biopsy. Read More

Asian Pac J Cancer Prev 2019 Mar 26;20(3):929-934. Epub 2019 Mar 26.

Department of General Surgery and Urology, Faculty of Medicine, Jordan University of Science and Technology, Jordan. Email:

Objectives: There is no consensus regarding the surgical or immunosuppressive treatment of idiopathic granulomatous mastitis (IGM). This study aimed to introduce a clinical classification system for IGM that might facilitate its treatment and predict recurrence. Methods: We analyzed the management of 68 patients with IGM at (Princess Basma Teaching Hospital and King Abdulla University Hospital (1994-2016) to find out if distinct patterns of presentation exist according to the following parameters: presence of a painful or painless breast mass, local inflammation, abscess formation, communication to the skin, and extra-mammary manifestation. Read More

Cureus 2019 Jan 16;11(1):e3896. Epub 2019 Jan 16.

Endocrinology, Universidad De Antioquia, Medellin, COL.

Cushing's syndrome is characterized by excessive glucocorticoid secretion leading to immunosuppression. The unmasking or aggravation of autoimmune diseases upon the normalization of cortisol levels after Cushing's syndrome cure has been reported infrequently. The case of a 45-year-old woman who presented with an 11-month history of severe signs and symptoms of hypercortisolism is reported. Read More

Clin Exp Rheumatol 2019 Mar 11. Epub 2019 Mar 11.

Department of Immunology and Department of Internal Medicine, Section of Clinical Immunology, Erasmus University Medical Center Rotterdam, the Netherlands.

Objectives: The TNF-blocker adalimumab can be effective in Behçet's disease (BD), a multisystem auto-inflammatory disorder. Unfortunately, the therapeutic efficacy of TNF-blockers can be hampered by the formation of anti-drug antibodies. We present an observational study of adalimumab in refractory BD with measurement of anti-drug antibodies. Read More

Melanoma Res 2019 Mar 11. Epub 2019 Mar 11.

Department of Ophthalmology.

To describe inflammatory side effects in patients treated with BRAF and MEK inhibitors at a single tertiary care institution. Retrospective chart review of patients prescribed single-agent or combination BRAF and MEK inhibitors from January 2010 until May 2015. The primary outcome was the presence of inflammatory side effects. Read More

Int J Mycobacteriol 2019 Jan-Mar;8(1):29-34

Department of Pathology, Government Medical College, Nagpur, Maharashtra, India.

Background: Erythema nodosum leprosum (ENL) classically presents with tender, coppery, evanescent nodules along with constitutional features and visceral involvement. However, uncommon morphological variants of ENL-like erythema nodosum necroticans, erythema multiforme (EM)-like ENL, Sweet's syndrome (SS)-like ENL, Lucio phenomenon, and reactive perforating type of ENL have also been described in the literature. The primary objective of this study was to describe the clinical features of the severe and uncommon morphological variants of ENL. Read More

Br J Dermatol 2019 Mar 6. Epub 2019 Mar 6.

Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Taipei, Linkou, Keelung, Taiwan.

Azathioprine (AZA) is a thiopurine-derived immunosuppressant commonly used in autoimmune and immunobullous dermatoses. AZA-hypersensitivity syndrome is a rare, but potentially fatal, immune-mediated reaction occurring within four weeks of administration. The polymorphism of TPMT and NUDT15 gene has been shown to increase the risk of AZA-induced leukopenia . Read More

Clin J Gastroenterol 2019 Mar 5. Epub 2019 Mar 5.

Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo, Japan.

Inflammatory bowel disease (IBD) is associated with a number of extraintestinal complications, including skin lesions. Most reports have shown that skin lesions are found in 10-15% of IBD cases, although this depends on the definition of skin lesions. The representative skin lesions in patients with IBD are erythema nodosum, pyoderma gangrenosum, Sweet's syndrome, and so on. Read More

Am J Dermatopathol 2019 Mar;41(3):239

National Hansen's Disease Programs, Healthcare Systems Bureau, Health Resources and Services Administration, U.S. Department of Health and Human Services, Baton Rouge, LA.

Yonsei Med J 2019 Mar;60(3):312-314

Department of Pediatrics, Saiseikai Shimonoseki General Hospital, Shimonoseki, Japan.

We report the first case demonstrating an association between Kawasaki disease (KD) and erythema nodosum (EN). A 3-year-old girl presented with EN as an initial manifestation of KD. At the initial visit, she showed high fever of 40°C, injection of the oropharynx, cervical lymphadenopathy, and red-purple cutaneous nodules, particularly on the lower limbs. Read More

Expert Rev Gastroenterol Hepatol 2019 Apr 20;13(4):307-317. Epub 2019 Feb 20.

a Department of Gastroenterology and Hepatology , University Hospital Zurich , Zurich , Switzerland.

Introduction: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder, primarily of, but not restricted to the gut. Extraintestinal manifestations (EIMs) are frequently observed and involve the joints, eyes, hepatobiliary tract, and skin. Areas covered: In this review, we discuss classical EIM focusing on epidemiology, genetics, and pathogenesis, highlighting recent advances in the understanding of EIM. Read More

QJM 2019 Feb 18. Epub 2019 Feb 18.

Department of Pathology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, India.

Background: Histoid leprosy is a subtype of leprosy with distinct clinical presentation and histologic features. It accounts for less than 4 per cent of leprosy cases. The exact location of histoid leprosy along the immune spectrum and its relation to other subtypes is unclear. Read More

Z Rheumatol 2019 Mar;78(2):180-182

Rheumatologie, Immunologie, Nephrologie, AK Altona, Paul-Ehrlich-Str. 1, 22763, Hamburg, Deutschland.

Whipple's disease is a rare infectious disease, which can affect various organ systems. Arthritis is a common symptom and therefore the infection is often misdiagnosed as seronegative rheumatoid arthritis. In rare cases an infection with Tropheryma whipplei can also cause skin lesions, such as subcutaneous nodules, erythema nodosum or vasculitis. Read More

Ter Arkh 2018 May;90(5):55-60

V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia.

Aim: The study of the course and outcomes of panniculitis (PN) in modern rheumatology practice.

Materials And Methods: We observed 209 patients (pts) (f-185, m-24 in age 17 to 80 years) with the input diagnosis "Erythema nodosum? Undifferentiated panniculitis?" and duration of illness in from 1 week to 25 years, observed in V.A. Read More

PLoS Negl Trop Dis 2019 01 28;13(1):e0007089. Epub 2019 Jan 28.

Department of Biochemistry, Biosciences Center, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.

Background: Leprosy is a treatable infectious disease caused by Mycobacterium leprae. However, there is additional morbidity from leprosy-associated pathologic immune reactions, reversal reaction (RR) and erythema nodosum leprosum (ENL), which occur in 1 in 3 people with leprosy, even with effective treatment of M. leprae. Read More

Neurol Int 2018 Dec 5;10(4):7852. Epub 2018 Dec 5.

Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan.

A 46-year-old woman developed slowly progressive tongue weakness with a pseudohypertrophic change on the right side of her tongue. She subsequently developed weakness in her proximal lower extremities, skin erythema and a sustained increase of muscle enzymes at 11 M after the onset. A biopsy of the quadriceps muscle showed necrotizing myopathy and a skin biopsy showed erythema nodosum. Read More

PLoS One 2019 25;14(1):e0210436. Epub 2019 Jan 25.

Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Background/aims: Extraintestinal cutaneous manifestations of IBD represent a severe disease complication and an early and accurate treatment might positively influence the disease course. Using the patient collective of the Swiss IBD Cohort Study (SIBDCS), we analysed epidemiological as well as clinical factors being associated with the onset of pyoderma gangrenosum, erythema nodosum and aphthous ulcers in IBD patients.

Methods: We included 3266 SIBDCs patients, 1840 with Crohn's disease (CD) and 1426 with ulcerative colitis (UC) or IBD unclassified (IBDU) and analysed the association of cutaneous manifestations with age, age at diagnosis time, type of disease, gender, family history, HLA-allotype, smoking, intestinal disease activity, therapy and other extraintestinal manifestations (EIM). Read More

Dermatol Online J 2018 Dec 15;24(12). Epub 2018 Dec 15.

Department of Dermatology, Coimbra University Hospital, Coimbra.

A 41-year-old woman presented with a violaceous papule on the dorsum of the hand, large ipsilateral axillary lymphadenopathy, and tender, erythematous, subcutaneous nodules on the legs. Accompanying signs included fever, ankle swelling, and bilateral red eye. She recalled having a previous exposure to kittens one month before and had a positive family history for sarcoidosis. Read More

Adv Rheumatol 2018 Oct 1;58(1):32. Epub 2018 Oct 1.

Internal Medicine and Endocrinology Department, Fattouma Bourguiba University Hospital, 1st June Avenue, 5000, Monastir, Tunisia.

Background: Cardiac and vascular involvement in Behçet disease (BD), also referred as vasculo BD, is frequent. We aimed to describe clinical characteristics, predictive factors and management of vasculo BD in the Tunisian context.

Methods: We retrospectively studied 213 records of all BD patients followed between January 2004 and May 2016 in the Internal Medicine Department and who fulfilled the ISGBD criteria. Read More

Australas J Dermatol 2019 Jan 17. Epub 2019 Jan 17.

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Am J Trop Med Hyg 2019 Feb;100(2):377-385

Leprosy Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.

Type 2 reaction (T2R) or (ENL), a sudden episode of acute inflammation predominantly affecting lepromatous leprosy patients (LL), characterized by a reduced cellular immune response. This possibly indicates a close relationship between the onset of T2R and the altered frequency, and functional activity of T lymphocytes, particularly of memory subsets. This study performed ex vivo and in vitro characterizations of T cell blood subpopulations from LL patients with or without T2R. Read More

Dermatol Ther 2019 Mar 23;32(2):e12811. Epub 2019 Jan 23.

Department of Health Sciences, Unit of Dermatology, Magna Graecia University, Catanzaro, Italy.

Mayo Clin Proc 2019 Jan;94(1):174-175

Department of Dermatology, Mitoyo General Hospital, Kanonji, Japan.

Mult Scler Relat Disord 2019 Feb 25;28:155-158. Epub 2018 Dec 25.

Department of Pathology & Lab Medicine, King Abdulaziz Medical City, Jeddah, Saudi Arabia.

Erythema nodosum is an uncommon cutaneous hypersensitivity reaction characterized by tender round slightly raised red nodules that become bruise-like and then resolve without scarring. It may be caused by infections, pregnancy, malignancy, systemic illnesses, or idiopathic. Several drugs have been reported in association with erythema nodosum including oral contraceptive pills, penicillin, and sulphonamides. Read More

PLoS Negl Trop Dis 2018 12 28;12(12):e0007035. Epub 2018 Dec 28.

London School of Hygiene and Tropical Medicine (LSHTM), London, United Kingdom.

Background: Erythema nodosum leprosum (ENL) is a systemic inflammatory complication occurring mainly in patients with lepromatous leprosy (LL) and borderline lepromatous leprosy (BL). Prednisolone is widely used for treatment of ENL reactions. However, it has been reported that prolonged treatment with prednisolone increases the risk for prednisolone-induced complications such as osteoporosis, diabetes, cataract and arteriosclerosis. Read More

Isr Med Assoc J 2018 Dec;20(12):770-772

Department of Internal Medicine F, Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.

Background: Erythema nodosum (EN) is the most common type of panniculitis, commonly secondary to infectious diseases.

Objectives: To elucidate the causative factors and the clinical presentation of patients with EN (2004-2014) and to compare their data to those reported in a previous study.

Methods: A retrospective study was conducted of all patients diagnosed with EN who were hospitalized at Soroka University Medical Center (2004-2014). Read More

Medicine (Baltimore) 2018 Dec;97(49):e13211

Department of Hematology.

Rationale: Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a rare subtype of non-Hodgkin lymphoma, which is rarely associated with erythema nodosum (EN).

Patient Concerns: A 57-year-old woman complained of recurrent rashes involving her abdomen, back, upper and lower limbs for over 20 years, with severity in symptoms for 2 weeks.

Diagnoses: The first skin biopsy was performed in 2011 in another hospital and she was diagnosed idiopathic EN. Read More

Indian J Dermatol 2018 Nov-Dec;63(6):465-468

Department of Pathology and Lab Medicine, AIIMS, Bhopal, Madhya Pradesh, India.

Background: Hansen's disease is a chronic infectious disease caused by . It is characterized by a wide range of clinical and histological manifestations. Ridley-Jopling criteria are widely used for classifying leprosy. Read More

Dermatology 2019 21;235(2):137-143. Epub 2018 Nov 21.

Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.

Objectives: Potassium iodide (KI) is a medication that has been used for decades in dermatology and it is mentioned as a treatment option in all major dermatology textbooks. Yet, there is little recent information on its efficacy. In our study, we wanted to retrospectively evaluate the therapy response to KI in our patients. Read More

Clin Exp Dermatol 2019 03 20;44(2):e16-e17. Epub 2018 Nov 20.

Department of Dermatology, Fukushima Medical University, Hikarigaoka 1, Fukushima, 960 1295, Japan.

J Obstet Gynaecol 2019 Apr 13;39(3):415-416. Epub 2018 Nov 13.

a Department of Family and Community Medicine , University of California San Francisco , San Francisco , CA , USA.

Infect Drug Resist 2018 10;11:1677-1683. Epub 2018 Oct 10.

Department of Molecular Biology, Stanley Browne Laboratory, TLM Community Hospital, Delhi, India,

Introduction: The most commonly noted reactions in leprosy patients are type 1 reactions and erythema nodosum leprosum, with some rare phenomenon of host response known as Lucio phenomenon or leprosy of Lucio and Latapi which is caused by . So far, no case of has been reported from India.

Materials And Methods: The main objective of this study was to detect any positive cases of in India with such a complication. Read More

J Assoc Physicians India 2018 04;66(4):63-6

Professor Department of Medicine.

A 30-year old male presented with fever for last 1 year. There were associated multiple painful skin eruptions with hyperpigmentation and scaling over whole body which had been progressively increasing. He also had anasarca along with generalized weakness. Read More

J Hand Surg Eur Vol 2019 Jan 18;44(1):88-95. Epub 2018 Oct 18.

School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK.

Thalidomide remains notorious as a result of the damage it caused to children born to mothers who used it to treat morning sickness between 1957 and 1961. The re-emergence of the drug to treat a range of conditions including erythema nodosum leprosum (a complication of leprosy) has led to a new generation of thalidomide damaged children being born in Brazil. Although thalidomide affects most of the developing tissues and organs of the body, the damage to the limbs is striking. Read More

J Cutan Med Surg 2019 Jan/Feb;23(1):114-116. Epub 2018 Oct 16.

2 Department of Medicine, University of Toronto, Toronto, ON, Canada.

We present a patient with new-onset erythema nodosum leprosum months after successful treatment of her mid-borderline leprosy, which was likely triggered by a combination of antecedent influenza vaccination and upper respiratory tract infection. Read More

Oral Surg Oral Med Oral Pathol Oral Radiol 2019 Jan 7;127(1):55-61. Epub 2018 Sep 7.

Department of Oral Diagnosis, School of Dentistry, University of Campinas, Piracicaba, São Paulo, Brazil.

Cowden syndrome (CS) is a phosphatase and tensin homolog gene (PTEN)-associated condition characterized by multiple mucocutaneous hamartomas and an increased risk of malignancies. We reported an isolated case and another of several individuals in one family affected by CS. The isolated case showed typical features, including fibrocystic breast disease, benign thyroid nodules, and multiple papillomatous lesions in the face and oral cavity, and the cause was a novel nonsense mutation-guanine (G) to thymine (T) transition at position 940 (c. Read More

Am J Trop Med Hyg 2019 Jan;100(1):24-30

National Institute of Nursing Education, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

A subset of multibacillary (MB) leprosy patients manifest with clinical "nonresponsiveness" to the fixed-duration, World Health Organization multidrug therapy MB regimen (WHO-MDT-MBR). The aim of this retrospective study was to assess the effectiveness and safety of alternate anti-leprosy therapy (ALT) in such patients. This is an analysis of patients' records, registered in the leprosy clinic of our institute over a period of 6 years (2010-2015). Read More

Aging Male 2018 Oct 6:1-4. Epub 2018 Oct 6.

a Medicine, Infectious Disease Department, Hamad General Hospital-HMC , Hamad Medical Corp , Doha , Qatar.

Tuberculous mastitis (TBM) is relatively rare disease with an incidence ranging between 0.1 and 4%. Most of the cases are culture negative and often mistaken with chronic benign idiopathic granulomatous mastitis (IGM). Read More

Reumatismo 2018 Oct 3;70(3):155-164. Epub 2018 Oct 3.

Rheumatology Unit, S. Maria Hospital - USL, IRCCS Institute, Reggio Emilia.

The range of pathologies that are related to primitive vasculitis is broad, complex and not as typical as we would expect. Clinicians should be aware that several forms of primitive and systemic vasculitis, regardless of the size of the affected vessel, may exhibit identical histological alterations. This observation has important clinical implications as it means that cases of vasculitis do not correspond clinically and histologically. Read More

World J Pediatr 2018 Dec 29;14(6):548-554. Epub 2018 Sep 29.

Department of Pediatrics and Department of Dermatology and Skin Sciences, University of British Columbia, Vancouver, BC, Canada.

Background: Erythema nodosum can be associated with a number of systemic diseases. There is, however, a paucity of information in the pediatric literature on this condition. The purpose of this article is to familiarize pediatricians with the evaluation, diagnosis, and treatment of erythema nodosum. Read More

J Dermatolog Treat 2018 Nov 19:1-5. Epub 2018 Nov 19.

a Dermatology Unit, Department of Medical, Surgical and Experimental Sciences , University of Sassari , Sassari , Italy.

Background: Inflammatory bowel diseases (IBDs) are associated with extraintestinal manifestations including skin lesions. The intestinal microflora plays a key role in the development and course of IBD.

Aim: To examine the efficacy of probiotics and the occurrence of skin lesions in patients with IBD. Read More

Acta Dermatovenerol Alp Pannonica Adriat 2018 09;27(3):161-163

Department of Gastroenterology, University Medical Centre Maribor, Maribor, Slovenia.

Crohn's disease is a chronic inflammatory bowel disease. The disease is characterized by acute exacerbations with diarrhea, abdominal pain, fever, anorexia, intestinal bleeding, and weight loss. Immune-mediated diseases that are frequently associated with Crohn's disease include arthritis, ankylosing spondylitis, sacroiliitis, episcleritis, uveitis, and skin lesions, such as erythema nodosum and pyoderma gangrenosum. Read More