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Intern Med 2022 May 14. Epub 2022 May 14.

Division of Rheumatology, Department of Internal Medicine, Kameda Medical Center, Japan.

Rev Chilena Infectol 2021 10;38(5):707-712

Hospital Regional Lambayeque Perú, Perú.

Leprosy or Hansen's disease is one of the classic neglected diseases that still persists in Peru. The infection is caused by Mycobacterium leprae. The disease varies in a wide range of manifestations from tuberculoid (paucibacillary) to lepromatous (multibacillary) leprosy. Read More

Reumatismo 2022 May 3;74(1). Epub 2022 May 3.

Rheumatology Unit, Department of Medical Sciences, University of Ferrara.

The current coronavirus disease 2019 (COVID-19) pandemic is a global challenge with strong medical and socioeconomic implications. Hopes have been placed in the development of various vaccines. As the vaccination campaign is in progress, adverse effects need to be monitored closely. Read More

J Oncol Pharm Pract 2022 May 3:10781552221098422. Epub 2022 May 3.

Division of Hematology, Oncology, and Transplantation, Department of Medicine, 5635University of Minnesota, Minneapolis, MN, USA.

Introduction: Nodular skin lesions in patients with acute myeloid leukemia (AML) raise clinical suspicion for leukemia cutis versus fungal infections. Here, we report a rare case of treatment-related erythema nodosum (EN) in a patient with AML.

Case Report: Approximately 5 weeks after the initiation of sorafenib and one week after azacitidine initiation, a 32-year-old man with primary refractory AML presented with several painful red nodules on the lower extremities. Read More

Sarcoidosis Vasc Diffuse Lung Dis 2022 31;39(1):e2022013. Epub 2022 Mar 31.

Department of Dermatology, Fukushima Medical University, Fukushima, Japan.

Background: Erythema nodosum-like sarcoid lesion is a specific form of cutaneous sarcoidosis sometimes observed in Japanese patients, with a female predominance, involving the lower extremities. By contrast, erythema nodosum as a non-specific cutaneous manifestation associated with sarcoidosis is rare in Japan. Erythema nodosum-like sarcoid lesion resembles erythema nodosum only in appearance, but histologically shows sarcoid granulomas. Read More

Arthritis Res Ther 2022 04 29;24(1):98. Epub 2022 Apr 29.

Department of Rheumatology and Immunology, Huadong Hospital affiliated to Fudan University, #221 Yan'an West Road, Shanghai, 200040, People's Republic of China.

Background: Behçet's syndrome (BS) is a rare variant vasculitis which can involve the eyes and gastrointestinal systems. However, ocular involvement rarely overlaps with intestinal lesions. This study aimed to compare the clinical characteristics and laboratory parameters of ocular BS and intestinal BS patients in China and analyze the differences between two key phenotypes to verify the heterogeneous conditions in BS patients. Read More

PLoS Negl Trop Dis 2022 04 26;16(4):e0010378. Epub 2022 Apr 26.

Department of Dermatology, Venereology and Leprology; Postgraduate Institute of Medical Education and Research; Chandigarh, India.

J Ayub Med Coll Abbottabad 2022 Jan-Mar;34(1):194-196

Department of Medicine, Khyber Teaching Hospital, Peshawar, Pakistan.

Lofgren syndrome an acute form of sarcoidosis constitutes erythema nodosum, bilateral hilar adenopathy and arthralgia or arthritis. Here we present a case of a 28 years old young male patient who is a shopkeeper and farmer by profession admitted to inpatient department with chief complaints of bilateral painful nodules on his shins, low grade fever and pain multiple joints on both sides of the body. Suspicion of the Lofgren syndrome was made upon initial evaluation and patient was admitted to inpatient care facility for necessary comprehensive workup. Read More

Children (Basel) 2022 Apr 4;9(4). Epub 2022 Apr 4.

Pediatric Unit, Department of NEUROFARBA, Meyer Children's University Hospital University of Florence, Viale Pieraccini 24, 50137 Florence, Italy.

Erythema nodosum (EN) is the most frequent form of panniculitis in children. We performed a literature review analyzing studies on pediatric EN published from 1990 to February 2022. EN is rare in pediatric age. Read More

Eur J Breast Health 2022 Apr 1;18(2):195-198. Epub 2022 Apr 1.

Department of Surgery, Yuai-Kai Foundation & Oda Hospital, Kashima, Japan.

Granulomatous mastitis (GM) is a chronic inflammatory disease of the breast that usually occurs in women of reproductive age. However, GM during pregnancy is unusual and only one case of GM in the accessory breast has been reported so far. Here, we report an extremely rare case of GM in the accessory axillary breast of a pregnant woman. Read More

Br J Clin Pharmacol 2022 Apr 17. Epub 2022 Apr 17.

Department of Clinical Pharmacology, University Hospital of Monastir. University of Monastir, Tunisia.

Erythema nodosum (EN), the most common form of panniculitis, is a reactive inflammation of the subcutaneous fat clinically presented with a sudden onset of painful, erythematous, nodular, subcutaneous lesions, typically localized to the pretibial area. EN is commonly caused by numerous infections (especially beta-haemolytic streptococcal infections), autoimmune diseases (sarcoidosis), inflammatory bowel conditions and drugs. EN induced by Covid-19 vaccines is rarely reported. Read More

J Dermatol 2022 Apr 17. Epub 2022 Apr 17.

Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Sapporo, Japan.

Behçet's disease (BD) has a heterogeneous spectrum of disease manifestations featuring the involvement of different organs and can be characterized with different symptoms depending on the clinical department in charge. We retrospectively reviewed BD patients seen at our hospital and investigated the presence of neutrophils producing neutrophil extracellular traps (NET) in those patients. Immunolabeling of myeloperoxidase and histone citrullination proteins was performed on skin biopsies from three BD patients who had skin biopsy-proven superficial vein thrombophlebitis in their erythema nodosum-like lesions. Read More

Med Arch 2022 Feb;76(1):72-74

Department of Dermatology, College of Medicine, Imam Abdulrahman bin Faisal University, Dammam, Saudi Arabia.

Background: Erythema nodosum (EN) is a common form of panniculitis that could be triggered by numerous conditions including infectious and non-infectious conditions. So far, few cases of EN caused by COVID-19 vaccine had been reported.

Case Report: We report a case of atypical presentation of EN mimicking cellulitis in a patient who received the first dose of the Pfizer-BioNTech COVID-19 vaccine. Read More

Rev Soc Bras Med Trop 2022 8;55:e00362022. Epub 2022 Apr 8.

Hospital Sultanah Nora Ismail, Department of General Medicine, Johor, Malaysia.

Int J Dermatol 2022 Apr 11. Epub 2022 Apr 11.

Department of Pathology, ABVIMS and Dr. RML Hospital, New Delhi, India.

J Med Case Rep 2022 Apr 5;16(1):146. Epub 2022 Apr 5.

Flushing Hospital Medical Center, 4500 Parsons Boulevard, Flushing, NY, 11355, USA.

Background: Granulomatous mastitis is a rare inflammatory disease of the breast, typically seen in woman of child-bearing age. No definitive etiology has been described. In rare instances, this condition has been reported to be associated with extramammary manifestations such as erythema nodosum and arthritis. Read More

Vaccine 2022 Apr 28;40(19):2650-2651. Epub 2022 Mar 28.

Department of Medical and Toxicological Critical Care, Lariboisière Hospital, Paris University, INSERM UMRS-1144 Paris, France. Electronic address:

Trop Med Infect Dis 2022 Mar 2;7(3). Epub 2022 Mar 2.

Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga/Dr. Soetomo General Academic Hospital, Jl. Mayjen Prof. Dr. Moestopo No. 6-8, Surabaya 60286, Indonesia.

Erythema nodosum leprosum (ENL) is an acute immune complex-mediated condition of the dermis, subcutaneous tissue, and other tissues seen in patients with multibacillary (MB) leprosy, causing severe impairment to patients' quality of life. To date, there is no standard diagnostic criteria for ENL. We aimed to study the diagnostic value and accuracy of Neutrophil-to-Lymphocyte ratio (NLR), Lymphocyte-to-Monocyte ratio (LMR), and Platelet-to-Lymphocyte ratio (PLR) in diagnosing ENL. Read More

Arthritis Rheumatol 2022 05 21;74(5):735-751. Epub 2022 Mar 21.

Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia.

Objective: Autoinflammatory type I interferonopathies, chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature/proteasome-associated autoinflammatory syndrome (CANDLE/PRAAS), stimulator of interferon genes (STING)-associated vasculopathy with onset in infancy (SAVI), and Aicardi-Goutières syndrome (AGS) are rare and clinically complex immunodysregulatory diseases. With emerging knowledge of genetic causes and targeted treatments, a Task Force was charged with the development of "points to consider" to improve diagnosis, treatment, and long-term monitoring of patients with these rare diseases.

Methods: Members of a Task Force consisting of rheumatologists, neurologists, an immunologist, geneticists, patient advocates, and an allied health care professional formulated research questions for a systematic literature review. Read More

J Investig Med High Impact Case Rep 2022 Jan-Dec;10:23247096221086450

Department of General Medicine, Okayama University Hospital, Japan.

A 34-year-old Japanese person with male gender identity who had been taking intramuscular injection of methyltestosterone depot for 11 years after bilateral mastectomy noticed blurred vision 5 days after the second vaccination for COVID-19 (Tozinameran; Pfizer-BioNTech) in the interval of 3 weeks following the first vaccination. The patient was diagnosed as granulomatous iritis with mutton-fat keratic precipitates and small iris nodules at the pupillary margin in the right eye and began to have 0.1% betamethasone eye drops with good response. Read More

JAAD Case Rep 2022 May 12;23:12-14. Epub 2022 Mar 12.

Department of Pediatrics, University of California, Los Angeles, Los Angeles, California.

Dermatol Ther 2022 Mar 13:e15443. Epub 2022 Mar 13.

Department of Dermatology and Cutaneous Surgery, University of South Florida, Tampa, Florida, USA.

Aliment Pharmacol Ther 2022 May 11;55(9):1179-1191. Epub 2022 Mar 11.

Department of Gastroenterology and Hepatology, Cleveland Clinic Foundation, Cleveland, OH, USA.

Background And Aims: Extra-intestinal manifestations (EIMs) are a common complication of inflammatory bowel diseases (IBD), affecting up to half of the patients. Despite their high prevalence, information on standardised definitions, diagnostic strategies, and treatment targets is limited.

Methods: As a starting point for a national EIM study network, an interdisciplinary expert panel of 12 gastroenterologists, 4 rheumatologists, 3 ophthalmologists, 6 dermatologists, and 4 patient representatives was assembled. Read More

Ital J Dermatol Venerol 2022 Mar 11. Epub 2022 Mar 11.

Rutgers-New Jersey Medical School, Newark, NJ, USA -

Sarcoidosis is a multi-organ disease commonly evident with skin involvement. Cutaneous manifestations occur in about 25% of sarcoid patients and are of two types: histologically specific sarcoidal infiltrations and a cutaneous reaction pattern not containing sarcoidal changes, usually erythema nodosum. Cutaneous plaques, nodules, and tumors, sometimes with disfiguring facial features associated with pain and paresthesia. Read More

Eur J Case Rep Intern Med 2022 2;9(2):003163. Epub 2022 Feb 2.

Hospital Dr. Nélio Mendonça - SESARAM, EPERAM, Funchal, Portugal.

infection is an uncommon but potentially fatal zoonosis, especially when it culminates with septicaemia. Post-infectious complications like reactive arthritis and erythema nodosum are well described in the literature. On the other hand, the association between yersinosis and autoimmune haemolytic anaemia (AIHA) has only been established in one clinical case. Read More

Enferm Infecc Microbiol Clin (Engl Ed) 2022 03;40(3):151-152

Unidad de Enfermedades Infecciosas, Hospital Universitario San Cecilio, Granada, Spain.

Ther Apher Dial 2022 Jun 10;26(3):522-528. Epub 2022 Mar 10.

Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, Japan.

Introduction: In recent years, the prevalence of inflammatory bowel diseases has been increasing in Japan due to the westernization of lifestyles. Many patients have been reported to have extra-intestinal manifestations (EIMs) at least once. Skin lesions occur with a high degree of frequency among EIMs, with erythema nodosum (EN) and pyoderma gangrenosum (PG) the main complications. Read More

Ann Med Surg (Lond) 2022 Mar 15;75:103363. Epub 2022 Feb 15.

Pediatric Gastroenterology and Hepatology Research Center, Children's Medical Center, Pediatric Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran.

Objective: Extraintestinal manifestations in irritable bowel disease (IBD), Crohn's disease and ulcerative colitis are reported in different system of the body. We aimed to investigate the factors determining disease severity and evaluate extraintestinal manifestations in patients with irritable bowel disease based on disease activity scoring system.

Methods: This cross-sectional study was conducted on all patients with irritable bowel disease referred to clinic and gastroenterology ward of (XXX). Read More

Braz J Infect Dis 2022 Mar-Apr;26(2):102336. Epub 2022 Feb 25.

Department of Nephrology, Rouen University Hospital, Bois-Guillaume, France.

We report a rare case of Campylobacter fetus bacteremia in a 50-year-old woman following kidney transplantation. Bacteremia was complicated by multivisceral signs such as multiple splenic abscesses, bacterial hepatitis, erythema nodosum and reactive arthritis. Despite a prolonged diagnostic delay, the diagnosis was made on blood culture identification and the global outcome was favorable with adequate antibiotherapy. Read More

J Eur Acad Dermatol Venereol 2022 Feb 28. Epub 2022 Feb 28.

Department of Dermatology, Hadassah Medical Center, Hebrew University of Jerusalem, The Faculty of Medicine, Jerusalem, Israel.