4,407 results match your criteria Erythema Nodosum


Extraintestinal manifestations in inflammatory bowel disease - epidemiology, genetics, and pathogenesis.

Expert Rev Gastroenterol Hepatol 2019 Feb 4:1-11. Epub 2019 Feb 4.

a Department of Gastroenterology and Hepatology , University Hospital Zurich , Zurich , Switzerland.

Introduction: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder, primarily of, but not restricted to the gut. Extraintestinal manifestations (EIMs) are frequently observed and involve the joints, eyes, hepatobiliary tract, and skin. Areas covered: In this review, we discuss classical EIM focusing on epidemiology, genetics, and pathogenesis, highlighting recent advances in the understanding of EIM. Read More

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http://dx.doi.org/10.1080/17474124.2019.1574569DOI Listing
February 2019

Does histoid leprosy represent a locally hyperimmune variant of lepromatous leprosy?

QJM 2019 Feb 18. Epub 2019 Feb 18.

Department of Pathology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, India.

Background: Histoid leprosy is a subtype of leprosy with distinct clinical presentation and histologic features. It accounts for less than 4 per cent of leprosy cases. The exact location of histoid leprosy along the immune spectrum and its relation to other subtypes is unclear. Read More

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http://dx.doi.org/10.1093/qjmed/hcz043DOI Listing
February 2019

[Rare erosive arthritis and dermatitis syndrome in Whipple's disease].

Z Rheumatol 2019 Feb 4. Epub 2019 Feb 4.

Rheumatologie, Immunologie, Nephrologie, AK Altona, Paul-Ehrlich-Str. 1, 22763, Hamburg, Deutschland.

Whipple's disease is a rare infectious disease, which can affect various organ systems. Arthritis is a common symptom and therefore the infection is often misdiagnosed as seronegative rheumatoid arthritis. In rare cases an infection with Tropheryma whipplei can also cause skin lesions, such as subcutaneous nodules, erythema nodosum or vasculitis. Read More

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http://dx.doi.org/10.1007/s00393-019-0602-2DOI Listing
February 2019
3 Reads

Panniculitis in rheumatology: features of course and outcomes.

Ter Arkh 2018 May;90(5):55-60

V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia.

Aim: The study of the course and outcomes of panniculitis (PN) in modern rheumatology practice.

Materials And Methods: We observed 209 patients (pts) (f-185, m-24 in age 17 to 80 years) with the input diagnosis "Erythema nodosum? Undifferentiated panniculitis?" and duration of illness in from 1 week to 25 years, observed in V.A. Read More

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http://dx.doi.org/10.26442/terarkh201890555-60DOI Listing
May 2018
1 Read

Differential immunoglobulin and complement levels in leprosy prior to development of reversal reaction and erythema nodosum leprosum.

PLoS Negl Trop Dis 2019 01 28;13(1):e0007089. Epub 2019 Jan 28.

Department of Biochemistry, Biosciences Center, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.

Background: Leprosy is a treatable infectious disease caused by Mycobacterium leprae. However, there is additional morbidity from leprosy-associated pathologic immune reactions, reversal reaction (RR) and erythema nodosum leprosum (ENL), which occur in 1 in 3 people with leprosy, even with effective treatment of M. leprae. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366718PMC
January 2019
2 Reads

A unique case of hemi-tongue pseudohypertrophy, necrotizing myopathy, and erythema nodosum.

Neurol Int 2018 Dec 5;10(4):7852. Epub 2018 Dec 5.

Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan.

A 46-year-old woman developed slowly progressive tongue weakness with a pseudohypertrophic change on the right side of her tongue. She subsequently developed weakness in her proximal lower extremities, skin erythema and a sustained increase of muscle enzymes at 11 M after the onset. A biopsy of the quadriceps muscle showed necrotizing myopathy and a skin biopsy showed erythema nodosum. Read More

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http://dx.doi.org/10.4081/ni.2018.7852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322047PMC
December 2018
1 Read

Occurrence of skin manifestations in patients of the Swiss Inflammatory Bowel Disease Cohort Study.

PLoS One 2019 25;14(1):e0210436. Epub 2019 Jan 25.

Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Background/aims: Extraintestinal cutaneous manifestations of IBD represent a severe disease complication and an early and accurate treatment might positively influence the disease course. Using the patient collective of the Swiss IBD Cohort Study (SIBDCS), we analysed epidemiological as well as clinical factors being associated with the onset of pyoderma gangrenosum, erythema nodosum and aphthous ulcers in IBD patients.

Methods: We included 3266 SIBDCs patients, 1840 with Crohn's disease (CD) and 1426 with ulcerative colitis (UC) or IBD unclassified (IBDU) and analysed the association of cutaneous manifestations with age, age at diagnosis time, type of disease, gender, family history, HLA-allotype, smoking, intestinal disease activity, therapy and other extraintestinal manifestations (EIM). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210436PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347222PMC
January 2019

Erythema nodosum and sarcoid granulomas - letting the cat out of the bag.

Dermatol Online J 2018 Dec 15;24(12). Epub 2018 Dec 15.

Department of Dermatology, Coimbra University Hospital, Coimbra.

A 41-year-old woman presented with a violaceous papule on the dorsum of the hand, large ipsilateral axillary lymphadenopathy, and tender, erythematous, subcutaneous nodules on the legs. Accompanying signs included fever, ankle swelling, and bilateral red eye. She recalled having a previous exposure to kittens one month before and had a positive family history for sarcoidosis. Read More

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December 2018
1 Read

Cardiac and vascular complications of Behçet disease in the Tunisian context: clinical characteristics and predictive factors.

Adv Rheumatol 2018 Oct 1;58(1):32. Epub 2018 Oct 1.

Internal Medicine and Endocrinology Department, Fattouma Bourguiba University Hospital, 1st June Avenue, 5000, Monastir, Tunisia.

Background: Cardiac and vascular involvement in Behçet disease (BD), also referred as vasculo BD, is frequent. We aimed to describe clinical characteristics, predictive factors and management of vasculo BD in the Tunisian context.

Methods: We retrospectively studied 213 records of all BD patients followed between January 2004 and May 2016 in the Internal Medicine Department and who fulfilled the ISGBD criteria. Read More

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http://dx.doi.org/10.1186/s42358-018-0032-xDOI Listing
October 2018
1 Read

A case of erythema nodosum-like panniculitis induced by nivolumab in a patient with oesophageal cancer.

Australas J Dermatol 2019 Jan 17. Epub 2019 Jan 17.

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.1111/ajd.12970DOI Listing
January 2019
1 Read

Involvement of TNF-Producing CD8 Effector Memory T Cells with Immunopathogenesis of Erythema Nodosum Leprosum in Leprosy Patients.

Am J Trop Med Hyg 2019 Feb;100(2):377-385

Leprosy Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.

Type 2 reaction (T2R) or (ENL), a sudden episode of acute inflammation predominantly affecting lepromatous leprosy patients (LL), characterized by a reduced cellular immune response. This possibly indicates a close relationship between the onset of T2R and the altered frequency, and functional activity of T lymphocytes, particularly of memory subsets. This study performed ex vivo and in vitro characterizations of T cell blood subpopulations from LL patients with or without T2R. Read More

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http://www.ajtmh.org/content/journals/10.4269/ajtmh.18-0517
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http://dx.doi.org/10.4269/ajtmh.18-0517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367624PMC
February 2019
6 Reads

Anti-interleukin 12/23 in the treatment of erythema nodosum and Crohn disease: A case report.

Dermatol Ther 2019 Jan 8:e12811. Epub 2019 Jan 8.

Department of Health Sciences, Unit of Dermatology, Magna Graecia University, Catanzaro, Italy.

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http://doi.wiley.com/10.1111/dth.12811
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http://dx.doi.org/10.1111/dth.12811DOI Listing
January 2019
7 Reads

Recurrent Erythema Nodosum as a Warning of Tuberculous Lymphadenitis.

Mayo Clin Proc 2019 Jan;94(1):174-175

Department of Dermatology, Mitoyo General Hospital, Kanonji, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S00256196183092
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http://dx.doi.org/10.1016/j.mayocp.2018.11.018DOI Listing
January 2019
1 Read

Erythema nodosum in a patient with multiple sclerosis on dimethyl fumarate.

Mult Scler Relat Disord 2018 Dec 25;28:155-158. Epub 2018 Dec 25.

Department of Pathology & Lab Medicine, King Abdulaziz Medical City, Jeddah, Saudi Arabia.

Erythema nodosum is an uncommon cutaneous hypersensitivity reaction characterized by tender round slightly raised red nodules that become bruise-like and then resolve without scarring. It may be caused by infections, pregnancy, malignancy, systemic illnesses, or idiopathic. Several drugs have been reported in association with erythema nodosum including oral contraceptive pills, penicillin, and sulphonamides. Read More

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http://dx.doi.org/10.1016/j.msard.2018.12.032DOI Listing
December 2018
1 Read

The effects of prednisolone treatment on serological responses and lipid profiles in Ethiopian leprosy patients with Erythema Nodosum Leprosum reactions.

PLoS Negl Trop Dis 2018 12 28;12(12):e0007035. Epub 2018 Dec 28.

London School of Hygiene and Tropical Medicine (LSHTM), London, United Kingdom.

Background: Erythema nodosum leprosum (ENL) is a systemic inflammatory complication occurring mainly in patients with lepromatous leprosy (LL) and borderline lepromatous leprosy (BL). Prednisolone is widely used for treatment of ENL reactions. However, it has been reported that prolonged treatment with prednisolone increases the risk for prednisolone-induced complications such as osteoporosis, diabetes, cataract and arteriosclerosis. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328235PMC
December 2018
2 Reads

Clinical, Epidemiological, and Etiological Changes in Erythema Nodosum.

Isr Med Assoc J 2018 Dec;20(12):770-772

Department of Internal Medicine F, Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.

Background: Erythema nodosum (EN) is the most common type of panniculitis, commonly secondary to infectious diseases.

Objectives: To elucidate the causative factors and the clinical presentation of patients with EN (2004-2014) and to compare their data to those reported in a previous study.

Methods: A retrospective study was conducted of all patients diagnosed with EN who were hospitalized at Soroka University Medical Center (2004-2014). Read More

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December 2018
4 Reads

Primary cutaneous anaplastic large cell lymphoma arising from a long-standing erythema nodosum: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13211

Department of Hematology.

Rationale: Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a rare subtype of non-Hodgkin lymphoma, which is rarely associated with erythema nodosum (EN).

Patient Concerns: A 57-year-old woman complained of recurrent rashes involving her abdomen, back, upper and lower limbs for over 20 years, with severity in symptoms for 2 weeks.

Diagnoses: The first skin biopsy was performed in 2011 in another hospital and she was diagnosed idiopathic EN. Read More

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http://dx.doi.org/10.1097/MD.0000000000013211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310586PMC
December 2018

Clinico-Histological Correlation in Hansen's Disease: Three-year Experience at a Newly Established Tertiary Care Center in Central India.

Indian J Dermatol 2018 Nov-Dec;63(6):465-468

Department of Pathology and Lab Medicine, AIIMS, Bhopal, Madhya Pradesh, India.

Background: Hansen's disease is a chronic infectious disease caused by . It is characterized by a wide range of clinical and histological manifestations. Ridley-Jopling criteria are widely used for classifying leprosy. Read More

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http://dx.doi.org/10.4103/ijd.IJD_525_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233050PMC
December 2018
3 Reads

Potassium Iodide for Cutaneous Inflammatory Disorders: A Monocentric, Retrospective Study.

Dermatology 2018 Nov 21:1-7. Epub 2018 Nov 21.

Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.

Objectives: Potassium iodide (KI) is a medication that has been used for decades in dermatology and it is mentioned as a treatment option in all major dermatology textbooks. Yet, there is little recent information on its efficacy. In our study, we wanted to retrospectively evaluate the therapy response to KI in our patients. Read More

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http://dx.doi.org/10.1159/000494614DOI Listing
November 2018
21 Reads

Association of pyoderma gangrenosum, erythema nodosum and aseptic liver abscess without significant underlying disease.

Clin Exp Dermatol 2019 Mar 20;44(2):e16-e17. Epub 2018 Nov 20.

Department of Dermatology, Fukushima Medical University, Hikarigaoka 1, Fukushima, 960 1295, Japan.

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http://dx.doi.org/10.1111/ced.13838DOI Listing
March 2019
1 Read

Erythema nodosum in a postpartum primigravida: a case report.

J Obstet Gynaecol 2018 Nov 13:1-2. Epub 2018 Nov 13.

a Department of Family and Community Medicine , University of California San Francisco , San Francisco , CA , USA.

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http://dx.doi.org/10.1080/01443615.2018.1491960DOI Listing
November 2018

Detection of in patients with leprosy in India.

Infect Drug Resist 2018 10;11:1677-1683. Epub 2018 Oct 10.

Department of Molecular Biology, Stanley Browne Laboratory, TLM Community Hospital, Delhi, India,

Introduction: The most commonly noted reactions in leprosy patients are type 1 reactions and erythema nodosum leprosum, with some rare phenomenon of host response known as Lucio phenomenon or leprosy of Lucio and Latapi which is caused by . So far, no case of has been reported from India.

Materials And Methods: The main objective of this study was to detect any positive cases of in India with such a complication. Read More

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https://www.dovepress.com/detection-of-mycobacterium-leproma
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http://dx.doi.org/10.2147/IDR.S166035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188107PMC
October 2018
10 Reads

Erythema Nodosum Leprosum as a Rare and Challenging Cause of Pyrexia of Unknown Origin.

J Assoc Physicians India 2018 04;66(4):63-6

Professor Department of Medicine.

A 30-year old male presented with fever for last 1 year. There were associated multiple painful skin eruptions with hyperpigmentation and scaling over whole body which had been progressively increasing. He also had anasarca along with generalized weakness. Read More

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The teratogenic effects of thalidomide on limbs.

Authors:
Neil Vargesson

J Hand Surg Eur Vol 2019 Jan 18;44(1):88-95. Epub 2018 Oct 18.

School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK.

Thalidomide remains notorious as a result of the damage it caused to children born to mothers who used it to treat morning sickness between 1957 and 1961. The re-emergence of the drug to treat a range of conditions including erythema nodosum leprosum (a complication of leprosy) has led to a new generation of thalidomide damaged children being born in Brazil. Although thalidomide affects most of the developing tissues and organs of the body, the damage to the limbs is striking. Read More

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http://journals.sagepub.com/doi/10.1177/1753193418805249
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http://dx.doi.org/10.1177/1753193418805249DOI Listing
January 2019
17 Reads

Erythema Nodosum Leprosum Triggered by Antecedent Influenza Vaccine and Respiratory Tract Infection: A Case Report.

J Cutan Med Surg 2019 Jan/Feb;23(1):114-116. Epub 2018 Oct 16.

2 Department of Medicine, University of Toronto, Toronto, ON, Canada.

We present a patient with new-onset erythema nodosum leprosum months after successful treatment of her mid-borderline leprosy, which was likely triggered by a combination of antecedent influenza vaccination and upper respiratory tract infection. Read More

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http://dx.doi.org/10.1177/1203475418808759DOI Listing
October 2018
1 Read

Variable expressivity and novel PTEN mutations in Cowden syndrome.

Oral Surg Oral Med Oral Pathol Oral Radiol 2019 Jan 7;127(1):55-61. Epub 2018 Sep 7.

Department of Oral Diagnosis, School of Dentistry, University of Campinas, Piracicaba, São Paulo, Brazil.

Cowden syndrome (CS) is a phosphatase and tensin homolog gene (PTEN)-associated condition characterized by multiple mucocutaneous hamartomas and an increased risk of malignancies. We reported an isolated case and another of several individuals in one family affected by CS. The isolated case showed typical features, including fibrocystic breast disease, benign thyroid nodules, and multiple papillomatous lesions in the face and oral cavity, and the cause was a novel nonsense mutation-guanine (G) to thymine (T) transition at position 940 (c. Read More

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http://dx.doi.org/10.1016/j.oooo.2018.08.016DOI Listing
January 2019
3 Reads

Alternate Anti-Leprosy Regimen for Multidrug Therapy Refractory Leprosy: A Retrospective Study from a Tertiary Care Center in North India.

Am J Trop Med Hyg 2019 Jan;100(1):24-30

National Institute of Nursing Education, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

A subset of multibacillary (MB) leprosy patients manifest with clinical "nonresponsiveness" to the fixed-duration, World Health Organization multidrug therapy MB regimen (WHO-MDT-MBR). The aim of this retrospective study was to assess the effectiveness and safety of alternate anti-leprosy therapy (ALT) in such patients. This is an analysis of patients' records, registered in the leprosy clinic of our institute over a period of 6 years (2010-2015). Read More

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http://dx.doi.org/10.4269/ajtmh.18-0256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335923PMC
January 2019
2.700 Impact Factor

A case report of TB versus idiopathic granulomatous mastitis with erythema nodosum, reactive arthritis, cough, and headache.

Aging Male 2018 Oct 6:1-4. Epub 2018 Oct 6.

a Medicine, Infectious Disease Department, Hamad General Hospital-HMC , Hamad Medical Corp , Doha , Qatar.

Tuberculous mastitis (TBM) is relatively rare disease with an incidence ranging between 0.1 and 4%. Most of the cases are culture negative and often mistaken with chronic benign idiopathic granulomatous mastitis (IGM). Read More

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http://dx.doi.org/10.1080/13685538.2018.1504915DOI Listing
October 2018
4 Reads

Erythema nodosum.

World J Pediatr 2018 Dec 29;14(6):548-554. Epub 2018 Sep 29.

Department of Pediatrics and Department of Dermatology and Skin Sciences, University of British Columbia, Vancouver, BC, Canada.

Background: Erythema nodosum can be associated with a number of systemic diseases. There is, however, a paucity of information in the pediatric literature on this condition. The purpose of this article is to familiarize pediatricians with the evaluation, diagnosis, and treatment of erythema nodosum. Read More

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http://dx.doi.org/10.1007/s12519-018-0191-1DOI Listing
December 2018
10 Reads

Is probiotic use beneficial for skin lesions in patients with inflammatory bowel disease?

J Dermatolog Treat 2018 Nov 19:1-5. Epub 2018 Nov 19.

a Dermatology Unit, Department of Medical, Surgical and Experimental Sciences , University of Sassari , Sassari , Italy.

Background: Inflammatory bowel diseases (IBDs) are associated with extraintestinal manifestations including skin lesions. The intestinal microflora plays a key role in the development and course of IBD.

Aim: To examine the efficacy of probiotics and the occurrence of skin lesions in patients with IBD. Read More

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http://dx.doi.org/10.1080/09546634.2018.1527998DOI Listing
November 2018
3 Reads

Acute febrile neutrophilic dermatosis in a patient with Crohn's disease: case report and review of the literature.

Acta Dermatovenerol Alp Pannonica Adriat 2018 09;27(3):161-163

Department of Gastroenterology, University Medical Centre Maribor, Maribor, Slovenia.

Crohn's disease is a chronic inflammatory bowel disease. The disease is characterized by acute exacerbations with diarrhea, abdominal pain, fever, anorexia, intestinal bleeding, and weight loss. Immune-mediated diseases that are frequently associated with Crohn's disease include arthritis, ankylosing spondylitis, sacroiliitis, episcleritis, uveitis, and skin lesions, such as erythema nodosum and pyoderma gangrenosum. Read More

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September 2018
17 Reads

Metastatic vulvovaginal Crohn disease in the setting of well-controlled intestinal disease.

Cutis 2018 Aug;102(2):E16-E18

Dell Medical School, University of Texas Southwestern, Austin, USA.

The cutaneous manifestations of Crohn disease (CD) are varied and include pyoderma gangrenosum, erythema nodosum, and metastatic CD (MCD). The latter is defined as the occurrence of granulomatous lesions at a skin site distant from the gastrointestinal tract. Metastatic CD involving the vulva and perineum is rare and thus often is difficult to diagnose. Read More

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August 2018
4 Reads

A 32-Year-Old Woman With Tender Nodules That Ulcerate: Challenge.

Am J Dermatopathol 2018 Oct;40(10):e134-e135

Weill Cornell Medical College, New York, NY.

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http://dx.doi.org/10.1097/DAD.0000000000000877DOI Listing
October 2018

Arthritis in sarcoidosis: A multicentric study from India.

Int J Rheum Dis 2018 Sep 5;21(9):1728-1733. Epub 2018 Sep 5.

KGMU, Lucknow, India.

Introduction: Ten to 15% of patients with sarcoidosis have associated arthritis. Chronic arthritis is fairly uncommon. There is a paucity of data on articular manifestations of the disease from India. Read More

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http://dx.doi.org/10.1111/1756-185X.13349DOI Listing
September 2018
27 Reads
1.771 Impact Factor

Whole blood profiling of leprosy type 1(reversal) reactions highlights prominence of innate immune response genes.

BMC Infect Dis 2018 Aug 24;18(1):422. Epub 2018 Aug 24.

Fundação Oswaldo Cruz-FIOCRUZ, Rio de Janeiro, Brazil.

Background: The major factors contributing for nerve damage and permanent disabilities in leprosy are type 1 or reversal reactions (RR) and type 2 or erythema nodosum leprosum (ENL). Gene profiling of leprosy reactions have shown that different pathways are activated during the course of reactions, which is consistent with the exacerbated immune response exhibited by these patients.

Methods: We used qPCR to screen a panel of 90 genes related to the immune response in leprosy in RNA-derived peripheral leukocytes of patients with (N = 94) and without leprosy reactions (N = 57) in order to define expression signatures correlated to RR or ENL. Read More

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http://dx.doi.org/10.1186/s12879-018-3348-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109344PMC
August 2018
6 Reads

Idiopathic histiocytoid Sweet syndrome: a case report with clinical and histopathological considerations.

Int J Dermatol 2018 Oct 16;57(10):1182-1186. Epub 2018 Aug 16.

Department of Pathology - University Hospital and School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Background: Histiocytoid Sweet syndrome is characterized by a predominant neutrophilic dermal infiltrate. Usual clinical differential diagnosis includes erythema multiforme, drug eruption, and erythema nodosum. Histiocytoid Sweet syndrome is considered an uncommon histopathological variant of the disease. Read More

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http://dx.doi.org/10.1111/ijd.14159DOI Listing
October 2018
10 Reads

Possible immune adverse events as predictors of durable response to BRAF inhibitors in patients with BRAF V600-mutant metastatic melanoma.

Eur J Cancer 2018 Sep 7;101:229-235. Epub 2018 Aug 7.

Ella Lemelbaum Institute for Immuno-Oncology, Sheba Medical Center, Ramat-Gan, Israel; Department of Clinical Microbiology and Immunology, Sackler Faculty of Medicine, Tel Aviv University, Israel; Talpiot Medical Leadership Program, Sheba Medical Center, Ramat-Gan, Israel.

BRAF inhibitors (BRAFi) and MEK inhibitors (MEKi) are among the cornerstones of metastatic melanoma therapy demonstrating excellent response rates with duration of 7-12 m. Long-term benefit from these agents was reported in patients with normal lactate dehydrogenase (LDH) and less than three disease sites. However, a treatment-dependent marker for long-term efficacy is lacking. Read More

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http://dx.doi.org/10.1016/j.ejca.2018.06.030DOI Listing
September 2018
17 Reads

Successful Endovascular Treatment of a Ruptured Popliteal Artery Aneurysm in a Patient with Behcet Disease.

Ann Vasc Surg 2018 Nov 6;53:274.e1-274.e5. Epub 2018 Aug 6.

Department of Surgery, SMG-SNU Boramae Medical Center, Seoul, Korea.

Purpose: Arterial involvement of Behcet disease is often found in the form of a rapidly expanding aneurysm. We report a case of successful treatment of a ruptured popliteal artery aneurysm with a stent-graft insertion.

Case Report: A 55-year-old male patient was admitted because of pain and swelling in the right leg that had persisted for 15 days. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08905096183058
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http://dx.doi.org/10.1016/j.avsg.2018.05.076DOI Listing
November 2018
31 Reads

Adamantiades-Behçet Disease at the Beginning of the Silk Route: North-East Italian Experience.

Acta Dermatovenerol Croat 2017 Dec;25(4):295-297

Nicola di Meo, MD, Dermatology Department, University of Trieste, Ospedale Maggiore di Trieste, Piazza Ospedale 1, IV Piano Palazzina Infettivi, 34100 Trieste, Italy;

Dear Editor, Adamantiades-Behçet's disease (ABD) is an inflammatory disease classified as vasculitis, which was originally diagnosed in patients with aphthous stomatitis, genital ulcerations, and ocular manifestations. However, any organ or system may be involved, particularly the central and peripheral nervous systems, joints, as well as the gastrointestinal tract. The etiology of ABD is still not fully understood, but some evidence indicates that an autoimmune process could be triggered by an infectious or environmental agent specific for the geographic region (1). Read More

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December 2017
7 Reads

A Novel Adverse Event Associated with Olaparib Therapy in a Patient with Metastatic Breast Cancer.

Case Rep Oncol Med 2018 27;2018:9529821. Epub 2018 Jun 27.

Department of Medical Oncology, Memorial Sloan Kettering Cancer Center, New York City, NY, USA.

Olaparib was first FDA approved for use in women with advanced ovarian cancer and germline BRCA mutations. Based on the results of subsequent research, the use of this drug has been expanded to patients with metastatic breast cancer with germline BRCA mutation. With the use of a relatively new medication and a larger patient population eligible for therapy, monitoring for novel adverse events associated with therapy is important. Read More

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http://dx.doi.org/10.1155/2018/9529821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040243PMC

Necrotic erythema nodosum leprosum masquerading as cutaneous vasculitis.

Rheumatology (Oxford) 2019 Jan;58(1):85

Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.1093/rheumatology/key216DOI Listing
January 2019
1 Read
4.475 Impact Factor

Leprosy and its reactional episodes: Serum levels and possible roles of omega-3 and omega-6-derived lipid mediators.

Cytokine 2018 Dec 14;112:87-94. Epub 2018 Jul 14.

Laboratório de Microbiologia Celular, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, RJ, Brazil.

The disease leprosy is caused by Mycobacterium leprae. The disease displays a spectrum of clinical manifestations relating to the stage of the infection and the pathogen-specific immune response. The most frequent M. Read More

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http://dx.doi.org/10.1016/j.cyto.2018.07.008DOI Listing
December 2018
4 Reads

γδ T cells are associated with inflammation and immunopathogenesis of leprosy reactions.

Immunol Lett 2018 Aug 11;200:55-65. Epub 2018 Jul 11.

Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India. Electronic address:

Background: Leprosy reactions appear episodically in leprosy patients, which lead to high inflammation, morbidity and peripheral nerve damage. The role of Th17 cell has been well studied in leprosy reactions but the role of γδ or unconventional T cells which is an other major source of IL-17 in many diseases, not studied in leprosy reactional episodes.

Objective: The aim of the present study to elucidate the role of γδ T cells in leprosy reactions. Read More

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http://dx.doi.org/10.1016/j.imlet.2018.07.005DOI Listing

Paediatric Behçet's disease in Iran: report of 204 cases.

Clin Exp Rheumatol 2018 Nov-Dec;36(6 Suppl 115):135-140. Epub 2018 Jun 19.

Behçet's Disease Unit, Rheumatology Research Centre, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Objectives: This study proposed to report the characteristics of paediatric Behçet's disease (PED-BD) in a cohort of patients from Iran's registry and compare them with different reports throughout the world.

Methods: From a cohort of 7504 Iranian patients with Behçet's disease those diagnosed before the age of 16 years were included in this study. Data were collected on a standard protocol comprising 105 items, including demographic features, type of presentation, and different clinical and laboratory findings. Read More

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June 2018
15 Reads

Erythema nodosum in an adolescent patient with cryopyrin-associated periodic syndrome.

Clin Case Rep 2018 Jul 15;6(7):1241-1245. Epub 2018 May 15.

Department of Dermatology The Children's Hospital at Westmead Westmead NSW Australia.

Cryopyrin-associated periodic syndrome (CAPS) is a monogenetic auto-inflammatory disorder with systemic manifestations. Innate immune system aberrance is seen in both CAPS and erythema nodosum and this case may point to a previously unknown association. In pediatric patients with EN and systemic features, the possibility of underlying CAPS should be considered. Read More

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http://dx.doi.org/10.1002/ccr3.1578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028369PMC
July 2018
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Thalidomide remodels developing heart in chick embryo: discovery of a thalidomide mediated hematoma in heart muscle.

Naunyn Schmiedebergs Arch Pharmacol 2018 10 7;391(10):1093-1105. Epub 2018 Jul 7.

Vascular Biology Laboratory, AU-KBC Research Centre, Chennai, Tamil Nadu, India.

Despite of medical disaster caused by thalidomide in 1960s, the drug came to clinical use again for the treatment of erythema nodosum leprosum (ENL) and multiple myeloma. Recently, a new generation of children affected by thalidomide intake by their mothers during pregnancy has been identified in Brazil. In the past few years, there is the great enhancement in our understanding of the molecular mechanisms and targets of thalidomide with the help of modern OMICS technologies. Read More

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http://link.springer.com/10.1007/s00210-018-1532-2
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http://dx.doi.org/10.1007/s00210-018-1532-2DOI Listing
October 2018
32 Reads

Evaluation of Mean Platelet Volume in Patients With Behcet's Disease as an Indicator of Vascular Thrombosis.

Arch Iran Med 2018 Jun 1;21(6):234-239. Epub 2018 Jun 1.

University of Health Sciences, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Department of Dermatology, Ankara, Turkey.

Background: Patients with Behcet's disease (BD) are recognized with increased risk for venous and/or arterial thrombosis. Thrombotic tendency of BD is not known. Vascular injury, loss and dysfunction/hyperfunction of endothelial cells are believed to play a role in thrombosis development. Read More

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June 2018
5 Reads

Behçet's disease: minireview with emphasis on oral aspects.

Minerva Stomatol 2018 Dec 14;67(6):246-249. Epub 2018 Jun 14.

Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.

Adamatiades-Behçet disease (BD) is a primary systemic vasculitis of unknown origin, that may involve blood vessels of all sizes. The clinical hall-mark of the disease are recurrent oral aphthous ulcers, painful, sharply margined and often associated with recurrent genital ulcers. A variety of skin lesions, such as erythema nodosum-like nodules and purpuric lesions are frequently observed. Read More

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http://dx.doi.org/10.23736/S0026-4970.18.04135-3DOI Listing
December 2018
17 Reads

Breast panniculitis with liquefactive fat necrosis: A case report.

Exp Ther Med 2018 Jun 25;15(6):5523-5527. Epub 2018 Apr 25.

Department of Rheumatology and Immunology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, P.R. China.

Panniculitis is a group of heterogeneous disorders characterized by inflammation of the subcutaneous adipose tissue. Panniculitis of breast tissue as the initial manifestation has rarely been reported and is often misdiagnosed. Breast panniculitis may cause substantial morbidity and early diagnosis and treatment are important for the prognosis of the disease. Read More

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http://dx.doi.org/10.3892/etm.2018.6095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996672PMC
June 2018
26 Reads

Circulating immune complexome analysis identified anti-tubulin-α-1c as an inflammation associated autoantibody with promising diagnostic value for Behcet's Disease.

PLoS One 2018 14;13(6):e0199047. Epub 2018 Jun 14.

Department of Rheumatology and Immunology, Peking University People's Hospital and Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis Beijing, China.

Background: Behcet's disease (BD) is a chronic, multisystem-involved vasculitis and its pathogenesis remains elusive. No specific serological markers for BD diagnosis have been established. Identification of novel diagnostic biomarkers will be helpful in timely diagnostic and treatment for Behcet's disease. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0199047PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002243PMC
December 2018
42 Reads