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    1 OF 85

    Leprosy reactions: The predictive value of Mycobacterium leprae-specific serology evaluated in a Brazilian cohort of leprosy patients (U-MDT/CT-BR).
    PLoS Negl Trop Dis 2017 Feb 21;11(2):e0005396. Epub 2017 Feb 21.
    Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, GO, Brasil.
    Background: Leprosy reactions, reversal reactions/RR and erythema nodosum leprosum/ENL, can cause irreversible nerve damage, handicaps and deformities. The study of Mycobacterium leprae-specific serologic responses at diagnosis in the cohort of patients enrolled at the Clinical Trial for Uniform Multidrug Therapy Regimen for Leprosy Patients in Brazil/U-MDT/CT-BR is suitable to evaluate its prognostic value for the development of reactions.

    Methodology: IgM and IgG antibody responses to PGL-I, LID-1, ND-O-LID were evaluated by ELISA in 452 reaction-free leprosy patients at diagnosis, enrolled and monitored for the development of leprosy reactions during a total person-time of 780,930 person-days, i. Read More

    A granulomatous conundrum: Concurrent necrobiosis lipoidica, cutaneous sarcoidosis and erythema nodosum in a nondiabetic patient.
    Australas J Dermatol 2017 Feb 17. Epub 2017 Feb 17.
    Australian National University Medical School, Canberra, Australian Capital Territory, Australia.
    Necrobiosis lipoidica (NL) and cutaneous sarcoidosis are granulomatous disorders with a largely unknown aetiopathogenesis. Evidence of co-existing NL and sarcoidosis in the same patient may suggest a degree of overlap between these entities through shared granulomatous inflammatory pathways. Occasionally, one condition can mimic the other, making their distinction difficult. Read More

    Erythema nodosum and the risk of tuberculosis in a high incidence setting.
    Int J Circumpolar Health 2016 Jan;75(1):32666
    a Department of Epidemiology Research Statens Serum Institut , Copenhagen , Denmark.
    Objective This study estimates the erythema nodosum (EN) incidence in a tuberculosis (TB) endemic setting and evaluates the likelihood of a subsequent TB diagnosis among individuals with Mycobacterium tuberculosis infection (MTI) with or without EN. Design We estimated EN incidence rates (IRs) in East Greenland in 2010-2011 and conducted a cohort study following all individuals who tested positive for MTI from 1 January 2010 until 31 December 2012. A personal identifier allowed individual follow-up in the mandatory TB register. Read More

    Do clinical findings of Behçet's disease vary by gender?: A single-center experience from 329 patients.
    Eur J Rheumatol 2016 Dec 1;3(4):157-160. Epub 2016 Dec 1.
    Division of Rheumatology, Department of Internal Medicine, Eskişehir Osmangazi University School of Medicine, Eskişehir, Turkey.
    Objective: Behçet's disease (BD) is a systemic vasculitis with a significantly varying clinical course following relapses and remissions, which may involve a number of organs such as the skin, joints, lungs, and blood vessels as well as systems such as the central nervous system and gastrointestinal system. Its prognosis is known to be worse in males. There are several studies in the literature on the clinical features and gender distribution of BD. Read More

    Early diagnosis of early-onset sarcoidosis: a case report with functional analysis and review of the literature.
    Clin Rheumatol 2017 Jan 27. Epub 2017 Jan 27.
    Department of Infection and Host Defense, Graduate School of Medicine, Shinshu University, Matsumoto, Japan.
    This study examined the pathogenesis of early-onset sarcoidosis (EOS) in a patient with a rare NOD2 mutation and surveyed the literature to identify the hallmark features for early diagnosis. An infant girl suffering from prolonged fever and skin rash of multiple pinkish papules and subsequent erythema nodosum was referred to our institution. Skin biopsy and DNA sequencing were performed along with cytokine profiling of the patient's serum and stimulated mononuclear cells. Read More

    Panniculitis: A summary.
    Semin Diagn Pathol 2016 Dec 27. Epub 2016 Dec 27.
    Section of Dermatopathology,Dermatopathology, Division of Surgical Pathology & Cytopathology, University of Virginia Medical Center, Charlottesville, VA, USA. Electronic address:
    The diagnosis of panniculitis is felt to be a confusing topic by some pathologists. This summarical article presents inflammatory diseases of the subcutis in a systematic fashion, based on whether they are centered on fibrovascular septa or the adipose lobules, and whether morphologic vasculitis is present or not. Septocentric, non-vasculitis disorders include erythema nodosum, panniculitis that follows the use of "biological" therapeutic agents, lipodermatosclerosis, post-irradiation panniculitis, morphea profunda, and necrobiosis lipodica profunda. Read More

    Pyoderma Gangrenosum and Erythema Nodosum Revealing Takayasu's Arteritis.
    Case Rep Dermatol 2016 Sep-Dec;8(3):354-357. Epub 2016 Dec 7.
    University Hospital Basel, Basel, Switzerland; University of Basel, Basel, Switzerland.
    We report a Caucasian female who presented with simultaneous erythema nodosum and pyoderma gangrenosum due to underlying Takayasu's arteritis. Takayasu's arteritis is a chronic large vessel vasculitis of unknown cause. The disease has a worldwide distribution but is most commonly seen in Asian populations. Read More

    Erythema Nodosum Leprosum-Like Lesions Are a Histopathologic Pattern in Whipple's Disease and a Sign of the Immune Reconstitution Inflammatory Syndrome: A Case Series and Review of the Literature.
    Am J Dermatopathol 2017 Jan 10. Epub 2017 Jan 10.
    *Dermatopathology Duisburg, Duisburg, Germany; †Department of Pathology, APHP Cochin Hospital, University Paris-Descartes, Paris, France; ‡Department of Dermatology, Saint Pierre-Brugmann and Children's University Hospitals, UniversiteLibre de Bruxelles, Brussels, Belgium; and §Divisions of Dermatopathology and Dermatology, Department of Pathology, Albany Medical College, Albany, NY.
    Inflammatory and subcutaneous nodules can arise in treated and untreated cases of Whipple disease (WD). The inflammatory immune reconstitution syndrome describes paradoxical clinical inflammatory worsening of a preexisting condition because of a return of immune function. Clinicopathologic examination of 4 patients with WD who presented with erythema nodosum leprosum (ENL)-like lesions and the findings of a systematic review of this phenomenon revealed that ENL-like lesions occurred in predominantly middle-aged male patients who suffered from WD, mostly on the legs. Read More

    Granulomatous Lung Disease: A Novel Complication following Metallosis from Hip Arthroplasty.
    Hip Pelvis 2016 Dec 28;28(4):249-253. Epub 2016 Dec 28.
    Department of Orthopedics, Iaso General Hospital, Athens, Greece.
    A case of a female patient with local and systemic complications of metallosis, following catastrophic wear of a revised hip arthroplasty, is presented. The patient had a history of a fractured ceramic-on-ceramic implant, exchanged with a metal-on-polyethylene prosthesis. Systemic complications included sarcoidosis-like reactions, presenting as granulomatous lung disease, along with chorioretinitis, erythema nodosum, and cardiomyopathy. Read More

    Disease-related and drug-induced skin manifestations in inflammatory bowel disease.
    Expert Rev Gastroenterol Hepatol 2017 Mar 1;11(3):203-214. Epub 2017 Feb 1.
    d Department of Biomedical Sciences , Humanitas University , Milan , Italy.
    Introduction: Skin manifestations are common in patients with inflammatory bowel diseases (IBD) and can be part of a concomitant illness with a shared genetic background, an extra-intestinal manifestation of the disease, or a drug side-effect. Areas covered: We provide a practical overview of the epidemiology, pathogenesis, diagnosis, therapeutic approach and prognosis of the most frequent disease-related and drug-induced cutaneous manifestations in IBD, illustrated by cases encountered in our clinical practice. Among the most frequently encountered IBD-related lesions are erythema nodosum, pyoderma gangrenosum and Sweet's syndrome. Read More

    Clinical Features and Extraintestinal Manifestations of Crohn Disease in Children.
    Pediatr Gastroenterol Hepatol Nutr 2016 Dec 28;19(4):236-242. Epub 2016 Dec 28.
    Department of Pediatrics, Pusan National University School of Medicine, Busan, Korea.
    Purpose: The aim of this study was to investigate the clinical features and extraintestinal manifestations (EIMs) of Crohn disease (CD) in Korean pediatric patients.

    Methods: The medical records of 73 children diagnosed with CD were retrospectively reviewed. Data regarding baseline demographic and clinical characteristics, including CD phenotype at diagnosis based on the Montreal classification, and clinical features and course of EIMs were investigated. Read More

    Ichthyosiform sarcoidosis: report of three cases from Japan and literature review.
    Sarcoidosis Vasc Diffuse Lung Dis 2016 Dec 23;33(4):392-397. Epub 2016 Dec 23.
    Fukushima Medhical University School of Medicine Department of Dermatology.
    Cutaneous lesions of sarcoidosis present with various manifestations including specific and non-specific cutaneous lesions. Ichthyosiform sarcoidosis is a rare form of cutaneous sarcoidosis, presenting with asymptomatic, adherent, polygonal scales, mainly appearing on the lower limbs.  Ichthyosiform sarcoidosis has a predilection for dark-skinned races, and cases affecting Japanese patients have rarely been reported in English literature. Read More

    Can baseline ML Flow test results predict leprosy reactions? An investigation in a cohort of patients enrolled in the uniform multidrug therapy clinical trial for leprosy patients in Brazil.
    Infect Dis Poverty 2016 Dec 6;5(1):110. Epub 2016 Dec 6.
    Tropical Pathology and Public Health Institute, Federal University of Goiás, Goiania, Goiás, Brazil.
    Background: The predictive value of the serology to detection of IgM against the Mycobacterium leprae-derived phenolic glycolipid-I/PGL-I to identify leprosy patients who are at higher risk of developing reactions remains controversial. Whether baseline results of the ML Flow test can predict leprosy reactions was investigated among a cohort of patients enrolled in The Clinical Trial for Uniform Multidrug Therapy for Leprosy Patients in Brazil (U-MDT/CT-BR).

    Methods: This was a descriptive study focusing on the main clinical manifestations of leprosy patients enrolled in the U-MDT/CT-BR from March 2007 to February 2012 at two Brazilian leprosy reference centers. Read More

    Leprosy reactions in postelimination stage: the Bangladesh experience.
    J Eur Acad Dermatol Venereol 2016 Nov 15. Epub 2016 Nov 15.
    Department of Medicine, Chittagong Medical College, Chittagong, Bangladesh.
    Background: Leprosy reactions are immunologically mediated conditions and a major cause of disability before, during and after multidrug therapy (MDT). Little data have been published on the epidemiology of leprosy reactions in Bangladesh.

    Objectives: To describe the pattern and prevalence of leprosy reactions in the postelimination stage. Read More

    [Cutaneous involvement in chronic inflammatory bowel disease : Crohn's disease and ulcerative colitis].
    Hautarzt 2016 Dec;67(12):940-947
    Abteilung für Dermatologie und Venerologie, Krankenanstalt Rudolfstiftung, Juchgasse 25, 1030, Wien, Österreich.
    Background: Over recent decades, both the incidence and prevalence of chronic inflammatory bowel disease have continued to rise in industrialized countries; the disease is frequently associated with extracutaneous involvement and comorbidity.

    Objectives: The purpose of this work was to investigate the frequency and specificity of mucocutaneous manifestations in Crohn's disease (CD) and ulcerative colitis (UC).

    Materials And Methods: An extensive search in peer-reviewed journals via PubMed was performed; presented is a summary and analysis of various studies and data, including data of patients treated at our department. Read More

    Metastatic Crohn disease clinically reminiscent of erythema nodosum on the right leg.
    Cutis 2016 Sep;98(3):E11-E15
    Department of Dermatology, Hanyang University Hospital, College of Medicine, Seoul, Korea.
    Cutaneous manifestations are well-recognized complications of Crohn disease (CD) that can be divided into disease-specific and reactive conditions. One of the most common reactive conditions is erythema nodosum (EN), which presents as subcutaneous tender nodules most often on the legs. On the other hand, metastatic Crohn disease (MCD) is a rare cutaneous manifestation of CD defined as the presence of noncaseating granulomas that are not contiguous with the gastrointestinal (GI) tract. Read More

    Inflammatory leg nodules: A clinical and investigational study.
    Natl Med J India 2016 May-Jun;29(3):141-145
    Department of Dermatology and Venereology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.
    Background: Inflammatory leg nodules are a diagnostically challenging group of dermatoses with limited tools for diagnosis. Considerable overlapping patterns exist despite their distinct clinical and histological features. We attempted to understand if undertaking investigations and studying the clinical course and treatment response can help in differentiating these dermatoses. Read More

    Erythema nodosum and the risk of tuberculosis in a high incidence setting.
    Int J Circumpolar Health 2016 25;75:32666. Epub 2016 Oct 25.
    Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
    Objective: This study estimates the erythema nodosum (EN) incidence in a tuberculosis (TB) endemic setting and evaluates the likelihood of a subsequent TB diagnosis among individuals with Mycobacterium tuberculosis infection (MTI) with or without EN.

    Design: We estimated EN incidence rates (IRs) in East Greenland in 2010-2011 and conducted a cohort study following all individuals who tested positive for MTI from 1 January 2010 until 31 December 2012. A personal identifier allowed individual follow-up in the mandatory TB register. Read More

    Erythema Nodosum-Like Panniculitis as a False-Positive 18F-FDG PET/CT in Advanced Melanoma Treated With Dabrafenib and Trametinib.
    Clin Nucl Med 2017 Jan;42(1):44-46
    From the Departments of *Nuclear Medicine, and †Oncology, Marqués de Valdecilla University Hospital, Molecular Imaging Group (IDIVAL), University of Cantabria, Santander, Spain.
    We present a 35-year-old woman with left axillary mass. Histopathological analysis revealed metastatic infiltration for BRAF-mutant melanoma. F-FDG PET/CT showed bilateral axillary lymphadenopathy as well as bone and subcutaneous metastases. Read More

    Clinical features of Sarcoidosis in Oman: A report from the Middle East region.
    Sarcoidosis Vasc Diffuse Lung Dis 2016 Oct 7;33(3):201-208. Epub 2016 Oct 7.
    Sultan Qaboos University.
    Background: Though clinical features of sarcoidosis follow a similar pattern, some heterogeneity is seen in different ethnic and racial groups.

    Objectives: To describe for the first time the clinical characteristics of sarcoidosis patients in the Sultanate of Oman.

    Methods: The data on all cases of sarcoidosis followed up in the two tertiary hospitals in Oman were retrieved retrospectively. Read More

    Characteristics of sarcoidosis in Maori and Pacific Islanders.
    Respirology 2017 Feb 12;22(2):360-363. Epub 2016 Oct 12.
    Respiratory Services, North Shore Hospital, Waitemata District Health Board, Auckland, New Zealand.
    Background And Objective: Ethnicity is strongly associated with variable clinical presentation in sarcoidosis but the association between ethnicity and clinical characteristics has not previously been described in patients of Polynesian ancestry, Maori and Pacific Islander (PI). The objective of this study was to describe the clinical characteristics of sarcoidosis in Maori and PI patients and determine if those were different to European patients.

    Methods: A retrospective review of the medical records of 406 patients (69 Maori/PI) attending a specialist interstitial lung disease (ILD) clinic. Read More

    An interesting case of Lucio phenomenon triggered by activation of hepatitis C infection.
    Indian Dermatol Online J 2016 Sep-Oct;7(5):406-409
    Department of Dermatology, St. Johns Medical College, Bangalore, Karnataka, India.
    Lucio phenomenon (LP) or erythema necroticans is a rare type of reaction pattern found in untreated patients with diffuse non-nodular leprosy. It is important to distinguish this from vasculonecrotic erythema nodosum because thalidomide with high-dose steroids is the mainstay of treatment for the latter, whereas LP shows no response to thalidomide. We report a case of a 60-year-old man who presented with purpuric patches, hemorrhagic blisters, and ulcers over extremities of 15 days duration. Read More

    Cell-type deconvolution with immune pathways identifies gene networks of host defense and immunopathology in leprosy.
    JCI Insight 2016 Sep 22;1(15):e88843. Epub 2016 Sep 22.
    Division of Dermatology, David Geffen School of Medicine at UCLA, California, USA.; Department of Microbiology, Immunology and Molecular Genetics, UCLA, Los Angeles, California, USA.
    Transcriptome profiles derived from the site of human disease have led to the identification of genes that contribute to pathogenesis, yet the complex mixture of cell types in these lesions has been an obstacle for defining specific mechanisms. Leprosy provides an outstanding model to study host defense and pathogenesis in a human infectious disease, given its clinical spectrum, which interrelates with the host immunologic and pathologic responses. Here, we investigated gene expression profiles derived from skin lesions for each clinical subtype of leprosy, analyzing gene coexpression modules by cell-type deconvolution. Read More

    Altered Markers of Brain Development in Crohn's Disease with Extraintestinal Manifestations - A Pilot Study.
    PLoS One 2016;11(9):e0163202. Epub 2016 Sep 21.
    Department of Neurology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
    Background And Objective: Alterations of brain morphology in Crohn's disease have been reported, but data is scarce and heterogenous and the possible impact of disease predisposition on brain development is unknown. Assuming a systemic course of the disease, brain involvement seems more probable in presence of extraintestinal manifestations, but this question has not yet been addressed. The present study examined the relationship between Crohn's disease and brain structure and focused on the connection with extraintestinal manifestations and markers of brain development. Read More

    Idiopathic granulomatous mastitis with erythema nodosum and polyarthritis.
    Reumatismo 2016 Sep 9;68(2):97-9. Epub 2016 Sep 9.
    Department of General Medicine, Muslim Educational Society Medical College, Malappuram.
    A 25 year-old woman presented with a painful mass in the left breast, polyarthritis and erythema nodosum. Fine needle aspiration cytology led to a diagnosis of granulomatous mastitis. Oral prednisolone rapidly improved the arthritis and the erythema nodosum. Read More

    Efficacy and adverse events of azacitidine in the treatment of hemodialysis patients with high-risk myelodysplastic syndrome.
    Rinsho Ketsueki 2016 Aug;57(8):1004-10
    Department of General Medicine, Japan Community Health Care Organization (JCHO) Kyushu Hospital.
    We describe two hemodialysis patients with high-risk myelodysplastic syndrome (MDS) treated with azacitidine. A 65-year-old woman (case 1) received azacitidine at 75 mg/m(2) for 7 days, and a 52-year-old man (case 2) with liver cirrhosis received a 70% dose of azacitidine. Both cases developed grade 4 cytopenia, but they achieved transfusion independence after 3 and 2 courses, and the durations of remission were 10 and 11 months, respectively. Read More

    Amyloïdosis, sarcoidosis and systemic lupus erythematosus.
    Pan Afr Med J 2016 6;24:23. Epub 2016 May 6.
    Internal Medicine Department, CHU Sahloul, Tunisia.
    The occurrence of renal and multiple organ Amyloïdosis is currently considered exceptional in the course of systemic lupus erythematosus. We report a case of a concomitant SLE and Amyloïdosis in a 57 year old female patient with hypothyroidism history, who presented with erythema nodosum, fever, arthralgia and sicca syndrome. Biological findings showed an inflammatory syndrome, renal failure, proteinuria (1g / 24h), positive auto antibodies and anti DNA. Read More

    Quality of life in patients with erythema nodosum leprosum in Kuala Lumpur, Malaysia.
    Indian Dermatol Online J 2016 Jul-Aug;7(4):255-8
    Department of Surveying, Lee Kong Chian Faculty of Engineering and Science, Universiti Tunku Abdul Rahman, Sungai Long Campus, Selangor DE, Jalan Pahang, Kuala Lumpur, Malaysia.
    Background: There is a paucity of data on quality of life issues in patients with leprosy suffering from erythema nodosum leprosum (ENL). Thus, we aim to study the effect of ENL on quality of life.

    Materials And Methods: This cross-sectional study was conducted in Hansen's Clinic, Hospital Kuala Lumpur between January 2010 and December 2013 among patients with multibacillary leprosy using the Dermatology Life Quality Index (DLQI). Read More

    Expression of CD64 on Circulating Neutrophils Favoring Systemic Inflammatory Status in Erythema Nodosum Leprosum.
    PLoS Negl Trop Dis 2016 Aug 24;10(8):e0004955. Epub 2016 Aug 24.
    Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
    Erythema Nodosum Leprosum (ENL) is an immune reaction in leprosy that aggravates the patient´s clinical condition. ENL presents systemic symptoms of an acute infectious syndrome with high leukocytosis and intense malaise clinically similar to sepsis. The treatment of ENL patients requires immunosuppression and thus needs to be early and efficient to prevent both disabilities and permanent nerve damage. Read More

    Erythema Nodosum-like Septal Panniculitis Secondary to Lenalidomide Therapy in a Patient With Janus Kinase 2-Positive Myelofibrosis.
    J Drugs Dermatol 2016 Aug;15(8):1024-5
    Erythema nodosum (EN) is a panniculitis frequently encountered secondary to medical therapy. We present a case of a 66-year-old gentleman with JAK2-positive myelofibrosis who developed transient EN-like lesions on his trunk and upper and lower extremities approximately three weeks after starting lenalidomide therapy. The subcutaneous nodules improved with intralesional triamcinolone and topical clobetasol without discontinuation of lenalidomide. Read More

    DNA Sensing via TLR-9 Constitutes a Major Innate Immunity Pathway Activated during Erythema Nodosum Leprosum.
    J Immunol 2016 Sep 29;197(5):1905-13. Epub 2016 Jul 29.
    Laboratory of Cellular Microbiology, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro 20045-900, Brazil;
    The chronic course of lepromatous leprosy may be interrupted by acute inflammatory episodes known as erythema nodosum leprosum (ENL). Despite its being a major cause of peripheral nerve damage in leprosy patients, the immunopathogenesis of ENL remains ill-defined. Recognized by distinct families of germline-encoded pattern recognition receptors, endogenous and pathogen-derived nucleic acids are highly immunostimulatory molecules that play a major role in the host defense against infections, autoimmunity, and autoinflammation. Read More

    [Epidemiology and Clinical Presentation of Sarcoidosis].
    Klin Monbl Augenheilkd 2016 Jul 25. Epub 2016 Jul 25.
    Sarcoidosis is a systemic disease of unknown aetiology. Typical histology shows epithelioid cell granulomas, and typical immunopathology enhanced Th1 type immune responses in the involved organs. The disease occurs worldwide, but more frequently in northern countries than in the south. Read More

    Immunohistochemical assessment of cell populations in leprosy-spectrum lesions and reactional forms.
    Histol Histopathol 2017 Apr 22;32(4):385-396. Epub 2016 Jul 22.
    Department of Pathology, Universidade Federal de São Paulo, São Paulo, Brazil.
    In situ immunophenotyping of leprosy lesions can improve our understanding of the biology of inflammatory cells during the immune response to Mycobacterium leprae antigens. In the present study, biopsies from 10 healthy controls and 70 leprosy patients were selected, 10 for each of the following conditions: clinical tuberculoid (TT), borderline tuberculoid (BT), borderline borderline (BB), borderline lepromatous (BL), lepromatous (LL), reversal reaction (R1), and erythema nodosum leprosum (R2). Qualitative and quantitative immunohistochemical analyses were performed to detect CD3, CD4, CD8, FoxP3, CD20, CD138, CD1a, CD57, CD15, CD117, CD68, and CD163. Read More

    Acute generalized pustular bacterid concomitant with erythema nodosum, polyarthritis, and Achilles tendinitis.
    Mod Rheumatol 2016 Jul 20:1-4. Epub 2016 Jul 20.
    b Center for Arthritis and Rheumatic Diseases .
    We report a case of acute generalized pustular bacterid (AGPB) concomitant with erythema nodosum (EN), polyarthritis, and Achilles tendinitis. The patient was admitted with a complaint of fever, widespread plural pustules, erythema, and polyarthralgia. Histopathological examination of the skin lesions demonstrated features of AGBP and EN. Read More

    Erythema nodosum - presentation of three cases.
    Reumatologia 2016 3;54(2):83-5. Epub 2016 Jun 3.
    Department of Rheumatology and Internal Diseases, University Hospital in Wroclaw, Wroclaw, Poland.
    Erythema nodosum (EN) is a well-known form of panniculitis. It may occur as an idiopathic form and also can be induced by certain clinical conditions such as infections and granulomatous diseases such as sarcoidosis. Erythema nodosum may be accompanied by general symptoms such as fever, weakness, and severe pain, but skin lesions resolve without skin damage. Read More

    Idiopathic Granulomatous Mastitis Associated with Erythema Nodosum.
    Balkan Med J 2016 Mar 1;33(2):228-31. Epub 2016 Mar 1.
    Department of Radiology, İzmir Atatürk Training and Research Hospital, İzmir, Turkey.
    Background: Idiopathic granulomatous mastitis (IGM) is an uncommon benign chronic inflammatory breast disease, and erythema nodosum (EN) is an extremely rare systemic manifestation of IGM. Here, we report a rare case of IGM accompanied by EN.

    Case Report: A 32-year-old patient was admitted to our clinic with a history of a tender mass in the right breast. Read More

    Systematic Review of Tumor Necrosis Factor Antagonists in Extraintestinal Manifestations in Inflammatory Bowel Disease.
    Clin Gastroenterol Hepatol 2017 Jan 5;15(1):25-36.e27. Epub 2016 Jul 5.
    Center for Observational and Real-World Evidence (CORE), Merck and Co, Inc, Kenilworth, New Jersey.
    Background & Aims: This systematic review investigated the efficacy and the effectiveness of biologic drugs in extraintestinal manifestations (EIMs) in inflammatory bowel disease (IBD).

    Methods: Literature search was conducted in PubMed, Embase, and Cochrane until October 2015. Main inclusion criteria were adults with IBD, use of a biologic drug, evolution of EIMs, interventional study, or non-interventional study. Read More

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