5,166 results match your criteria Erythema Multiforme Stevens-Johnson Syndrome


Interventions for erythema multiforme: a systematic review.

J Eur Acad Dermatol Venereol 2019 Jan 25. Epub 2019 Jan 25.

Service de Dermatologie, AP-HP, Hôpital Henri Mondor, F-9400, Créteil, France.

Treatment of erythema multiforme (EM) is not codified. We performed a systematic review of the effect of any topical or systemic treatment on time to healing and frequency of episodes with acute and chronic forms of EM in adults. Four databases (MEDLINE, CENTRAL, EMBASE and LILACS) and other sources were searched for articles published up to March20, 2018. Read More

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http://dx.doi.org/10.1111/jdv.15447DOI Listing
January 2019

Lacrimal passage irrigation in children with Stevens-Johnson syndrome or toxic epidermal necrolysis: a five-year retrospective study.

BMC Ophthalmol 2019 Jan 18;19(1):22. Epub 2019 Jan 18.

Department of Ophthalmology, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, 400014, China.

Background: To identity the effect of lacrimal system irrigation in the acute stage in children with Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN).

Methods: A retrospective review of 39 patients with SJS or TEN from 2012 to 2017 was analyzed. Patients were divided into two subgroups according to whether they received irrigation in the acute stage. Read More

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http://dx.doi.org/10.1186/s12886-018-1014-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339389PMC
January 2019
3 Reads

Allopurinol-Induced Stevens-Johnson Syndrome.

Am J Med Sci 2018 Dec 4. Epub 2018 Dec 4.

Department of Critical Care Medicine, Maimonides Medical Center, Brooklyn, New York.

Allopurinol is a first line agent in treating gout, but it also carries the risk of severe side effects. Stevens-Johnson syndrome (SJS) is one of the life threatening severe cutaneous adverse reactions caused by allopurinol. The severity of the severe cutaneous adverse reactions can be categorized based upon the area of skin involvement: (1) erythema multiforme major limited to 1-2 % of the body surface area (BSA); (2) SJS involving <10% of the BSA, (3) SJS and toxic epidermal necrolysis overlap involving 10-30% of the BSA and (4) toxic epidermal necrolysis syndrome involving >30% of the BSA. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029629183044
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http://dx.doi.org/10.1016/j.amjms.2018.11.018DOI Listing
December 2018
6 Reads

Toxic epidermal necrolysis after yellow fever vaccination.

An Bras Dermatol 2018 Nov/Dec;93(6):942-943

Medical Residency Program in Dermatology, Faculdade de Medicina de Jundiaí, Jundiaí (SP), Brazil.

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http://dx.doi.org/10.1590/abd1806-4841.20188237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256206PMC
February 2019
2 Reads

Treatment of oral manifestations of toxic epidermal necrolysis with low-level laser therapy in a pediatric patient.

Pediatr Dermatol 2019 Jan 26;36(1):e27-e30. Epub 2018 Nov 26.

Department of Oral Surgery and Pathology, Faculty of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Drug-induced reactions are complications associated with high mortality and significant morbidity. Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) are examples of these conditions, which are characterized by skin and mucous lesions. Here, we report a case of a 9-year-old girl who presented with blisters associated with an extensive vesicular rash and multiple ulcerations on the lips and oral cavity. Read More

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http://doi.wiley.com/10.1111/pde.13719
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http://dx.doi.org/10.1111/pde.13719DOI Listing
January 2019
12 Reads

Propranolol eye drops in patients with corneal neovascularization.

Medicine (Baltimore) 2018 Nov;97(45):e13002

Pediatric Ophthalmology Unit, Niguarda Ca' Granda Metropolitan Hospital, Milan, Italy.

Rationale: Studies performed in animal models of corneal neovascularization suggested the possible efficacy of a treatment with propranolol. Corneal neovascularization is one of the most feared complications of Stevens-Johnson syndrome that frequently involves ocular surface. We report the first 2 patients with severe ocular neo-vascularization treated with different degrees of success, with propranolol eye drops. Read More

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http://Insights.ovid.com/crossref?an=00005792-201811090-0001
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http://dx.doi.org/10.1097/MD.0000000000013002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250516PMC
November 2018
16 Reads

Generalized bullous fixed-drug eruption secondary to the influenza vaccine.

JAAD Case Rep 2018 Oct 12;4(9):953-955. Epub 2018 Oct 12.

University of North Carolina School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1016/j.jdcr.2018.07.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197945PMC
October 2018
3 Reads

[Boston Keratoprosthesis with temporal aponeurosis graft: A solution when there seems to be no more].

J Fr Ophtalmol 2018 Nov 19;41(9):830-835. Epub 2018 Oct 19.

Service d'ophtalmologie II, centre hospitalier national des Quinze-Vingts, 28, rue de Charenton, 75012 Paris, France.

Purpose: To report cases of patients with severe bilateral corneal blindness and recurrent refractory perforation to keratoplasty and conventional treatment, for whom Boston keratoprosthesis (KP) was a satisfactory alternative when combined with a temporalis aponeurosis graft.

Description Of Cases: The first patient had progressive Lyell syndrome with spontaneous corneal perforation. The second had a severe graft vs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01815512183029
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http://dx.doi.org/10.1016/j.jfo.2018.01.010DOI Listing
November 2018
12 Reads

Toxic epidermal necrolysis: the red eye and red herrings in casualty.

BMJ Case Rep 2018 Oct 12;2018. Epub 2018 Oct 12.

Department of Ophthalmology, Queen Elizabeth Hospital Birmingham, Birmingham, Birmingham, UK.

A 38-year-old woman presented to casualty with bilateral red eyes associated with a recent upper respiratory tract infection. This was initially diagnosed as conjunctivitis, however systemic review revealed an erythematous facial and skin rash, mildly swollen lips and mild swallowing difficulties. The patient was referred for an urgent medical assessment, by which time she was found to have erythema affecting 54% of her body surface area and diagnosed with suspected toxic epidermal necrolysis (TEN). Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22586
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http://dx.doi.org/10.1136/bcr-2018-225861DOI Listing
October 2018
12 Reads

Reasons for inpatient admissions to the dermatology department in Lomé, Togo : Trends between 1992 to 2005 and 2005 to 2016.

Med Sante Trop 2018 Aug;28(3):270-272

CHU Sylvanus Olympio, Lomé, Togo.

The aim of this study was to report the frequency of and reasons for dermatology admissions in Lomé (Togo) between 2005 and 2016. This retrospective study examined records from August 2005 to December 2016 from the dermatology departments of the two teaching hospitals in Lomé, Togo. During the study period, 454 (1. Read More

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http://dx.doi.org/10.1684/mst.2018.0813DOI Listing
August 2018
3 Reads

Experience in Using Fetal Membranes: The Present and New Perspectives.

Transplant Proc 2018 Sep 13;50(7):2188-2194. Epub 2018 Mar 13.

Dr Stanisław Sakiel Burn Treatment Centre in Siemianowice Śląskie, Siemianowice Śląskie, Poland; Department of Health Science, University of Technology and Humanities in Bielsko-Biała, Bielsko-Biała, Poland.

Introduction: The placenta is an accessible source of tissues for transplantation. Placental transplants have been used in wound treatment because of the basic function of the placenta and its nutritious properties and structure.

Patients And Methods: The aim of this work is to present the clinical usage of fetal membranes, including human amnion, on the basis of the burn treatment center's experience. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.02.120DOI Listing
September 2018
24 Reads

Anti-programmed cell death-1 therapy-associated bullous disorders: a systematic review of the literature.

Melanoma Res 2018 12;28(6):491-501

Departments of Dermatology.

Bullous disorders are rare adverse events associated with anti-programmed cell death-1 (anti-PD1) therapy. This paper presents two new cases of bullous disorders under anti-PD1 therapy and systematically reviewed the literature to foster a better understanding of the presentation and pathogenesis of bullous disorders under anti-PD1. A systematic review of the literature was completed using MEDLINE, Embase, PubMed and LILACS databases. Read More

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http://dx.doi.org/10.1097/CMR.0000000000000500DOI Listing
December 2018
8 Reads

Etoricoxib-induced toxic epidermal necrolysis: A fatal case report.

Indian J Pharmacol 2018 May-Jun;50(3):139-142

Department of Pathology, MGM Medical College, Kishanganj, Bihar, India.

Cyclooxygenase inhibitors were developed in the quest of enhanced analgesic efficacy devoid of gastric side effects. High usage of etoricoxib by prescription as well as self-administered routes has led to increasing reports of side effects and adverse reactions including dermatologic reactions in 0.1%-0. Read More

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http://www.ijp-online.com/text.asp?2018/50/3/139/239056
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http://dx.doi.org/10.4103/ijp.IJP_39_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106123PMC
December 2018
17 Reads

The Role of Biological Skin Substitutes in Stevens-Johnson Syndrome: Systematic Review.

Plast Surg Nurs 2018 Jul/Sep;38(3):121-127

André Oliveira Paggiaro, PhD, is at Guarulhos University, Guarulhos, SP, Brazil. Markinokoff Lima e Silva Filho, MN, is Nursing Postgraduation Student, Programa de Pós-Graduação em Enfermagem, Guarulhos University, Guarulhos, SP, Brazil. Viviane Fernandes de Carvalho, PhD, is at Guarulhos University, Guarulhos, SP, Brazil. César Isaac, PhD, is at São Paulo University, Sao Paulo, SP, Brazil. Rolf Gemperli, PhD, is at São Paulo University, Sao Paulo, SP, Brazil.

Stevens-Johnson syndrome (SJS) is a disease that causes skin exfoliative lesions, characterized by fever, necrosis, and epidermal detachment. Biological skin substitutes may be considered interesting options for the treatment of this disease. This study aims at identifying in the literature the evidence on the current role of these biomaterials in the treatment of SJS and its related diseases. Read More

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http://dx.doi.org/10.1097/PSN.0000000000000234DOI Listing
January 2019
20 Reads

Toxic epidermal necrolysis-like acute cutaneous lupus erythematosus: report of a case and review of the literature.

Dermatol Online J 2018 05 15;24(5). Epub 2018 May 15.

Department of Dermatology, University of California San Diego, La Jolla, California.

Severe bullous eruptions in systemic lupus erythematosus (SLE) patients include bullous SLE, Rowell syndrome, toxic epidermal necrolysis (TEN), and TEN-like eruption of acute cutaneous lupus (TEN-like ACLE). TEN-like ACLE, a rare manifestation of SLE that closely mimics TEN, can be distinguished by characteristic clinical and laboratory findings. A 27-year-old man with SLE who developed TEN-like ACLE after initiating mycophenolate mofetil for active SLE is reported. Read More

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May 2018
13 Reads

Striking enhancement at the site of radiation for nivolumab-induced Stevens-Johnson syndrome.

Dermatol Online J 2018 Jun 15;24(6). Epub 2018 Jun 15.

Indiana University School of Medicine, Department of Dermatology, Indianapolis, Indiana.

Stevens-Johnson syndrome is a rare adverse cutaneous drug reaction characterized by epidermal detachment of <10% body surface area with an average mortality rate of 1-5%. The mechanism of SJS is not fully understood. Nivolumab is a monoclonal antibody directed against programmed cell death-1 protein (PD-1), a receptor with immune checkpoint inhibitory and antineoplastic activities. Read More

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June 2018
17 Reads

Evaluation of a lymphocyte transformation test and cytokine detection assay to identify phenytoin and carbamazepine provoked DRESS or SJS/TEN in epilepsy patients.

Int Immunopharmacol 2018 Oct 10;63:204-210. Epub 2018 Aug 10.

Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglung Rd., Bangkok-noi, Bangkok 10700, Thailand. Electronic address:

Phenytoin (PHE) and carbamazepine (CBZ) are first rank causative drugs that can induce drug rash with eosinophilia and systemic symptoms (DRESS) and Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). Identification of anti-epileptic drugs as a culprit drug has been problematic; hence, in vitro tests could be promising methods to define causative drugs without clinical risk. The aim of this study is to evaluate the efficacy of lymphocyte transformation tests (LTT) and cytokine detection assays in identifying PHE and CBZ as culprit drugs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15675769183038
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http://dx.doi.org/10.1016/j.intimp.2018.08.010DOI Listing
October 2018
9 Reads

Toxic epidermal necrosis induced by carbamazepine embedded in the subcutis.

An Bras Dermatol 2018 Jul-Aug;93(4):620-621

Department of General Surgery, 306 Hospital of PLA, Beijing, China.

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http://dx.doi.org/10.1590/abd1806-4841.20187725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063118PMC
August 2018
6 Reads

Stevens-Johnson Syndrome: A Challenging Diagnosis.

Adv Emerg Nurs J 2018 Jul/Sep;40(3):176-182

Department of Adult Health Nursing (Dr Davis) and College of Nursing (Mr Schafer), University of South Alabama, Mobile; and PHI Air Medical, Phoenix, Arizona (Mr Schafer).

Stevens-Johnson syndrome is a rare, yet life-threatening, delayed-type hypersensitivity reaction characterized by mucocutaneous epidermal necrolysis. Toxic epidermal necrolysis is a severe manifestation of Stevens-Johnson syndrome, defined as greater than 30% skin detachment. Stevens-Johnson syndrome with toxic epidermal necrolysis is characterized as an adverse cutaneous drug reaction and is associated with the use of sulfonamides, antiepileptics, and some classes of nonsteroidal anti-inflammatory drugs. Read More

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http://dx.doi.org/10.1097/TME.0000000000000197DOI Listing
October 2018
8 Reads

A case report of toxic epidermal necrolysis associated with AZD-9291.

Drug Des Devel Ther 2018 11;12:2163-2167. Epub 2018 Jul 11.

Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, The People's Republic of China,

Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are a strain of small molecule inhibitors mainly used to treat the metastatic non-small cell lung cancer. Their predominant adverse effect is skin toxicity, usually manifested as acneiform rash, skin fissure, xerosis, and paronychia. Severe epidermal necrosis and exfoliation rarely occur. Read More

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http://dx.doi.org/10.2147/DDDT.S168248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047856PMC
December 2018
22 Reads

Toxic epidermal necrolysis-like acute cutaneous lupus erythematosus in a patient with progressive systemic sclerosis.

Lupus 2018 Oct 20;27(11):1860-1863. Epub 2018 Jul 20.

3 Department of Pathology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.

A 60-year-old female was diagnosed with progressive systemic sclerosis and interstitial lung disease of two months' duration. The patient was treated for Raynaud phenomenon with aspirin, nifedipine, colchicine, and naproxen. Two weeks after treatment, she developed widespread erythematous patches with blistering eruptions on the face, torso, and extremities, and also had erosion on the oral mucosa. Read More

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http://dx.doi.org/10.1177/0961203318789766DOI Listing
October 2018
3 Reads

Carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis overlap in a Filipino with positive HLA-B75 serotype.

BMJ Case Rep 2018 Jul 17;2018. Epub 2018 Jul 17.

Institute of Human Genetics, National Institutes of Health, University of the Philippines Manila, Manila, Philippines.

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are two related mucocutaneous disorders with different severities. Although the incidence is low, SJS and TEN are life-threatening and predominantly drug-induced conditions. There is a strong relationship between the allele and carbamazepine-induced SJS and TEN in different Southeast Asian populations. Read More

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http://dx.doi.org/10.1136/bcr-2018-225028DOI Listing
July 2018
4 Reads

[Toxic epidermal necrolysis during a hemophagocytic syndrome secondary to Hodgkin lymphoma. Report of one case].

Rev Med Chil 2018 Apr;146(4):523-527

Servicio de Anatomía patológica, Hospital del Salvador, Santiago, Chile.

Toxic epidermal necrolysis (TEN) is a lethal entity, characterized by extensive epidermal necrosis and multiorgan failure. Hemophagocytic syndrome (HFS) is also a rare and lethal syndrome characterized by hyperinflammation that leads to the appearance of fever, pancytopenia, organomegaly and hemophagocytosis. The concomitance of these diseases is extremely uncommon. Read More

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http://dx.doi.org/10.4067/s0034-98872018000400523DOI Listing
April 2018
14 Reads

Atypical Nevi in a Patient After Toxic Epidermal Necrolysis.

Acta Dermatovenerol Croat 2018 Jun;26(2):183-185

Ružica Jurakić Tončić, MD, Department of Dermatovenereology, University Hospital Centre Zagreb, University of Zagreb School of Medicine, Šalata 4, 10000 Zagreb, Croatia;

Dear Editor, There are few literature data about nevi in patients with a history of toxic epidermal necrolysis (TEN) and little recommendations for follow-up and risks of melanoma (MM). Eruptive melanocytic nevi (EMN) is a rare phenomenon that has been associated with bullous disorders, immunosuppression, and immunodeficiency, but in some cases can occur without precipitating factors (1). The etiology is largely unknown, but there is evidence that immunosuppression might play a crucial role in nevogenesis, probably due to the inability of the immune system to inhibit melanocytic (MC) proliferation (2,3). Read More

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June 2018
14 Reads

Stevens-Johnson and Lyell syndromes in children in a hospital setting in Lomé, Togo, from 2000 to 2015.

Med Sante Trop 2018 May;28(2):332-333

Service dermatologie et IST, CHU Sylvanus Olympio, Université de Lomé, 14 BP 200 Lomé, Togo.

Objective: The aim of this study was to document the profile of children with Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN, also called Lyell syndrome) in hospital settings in Lomé, Togo.

Method: This descriptive retrospective study examined the records of children aged 0 to 15, seen and/or hospitalized in the dermatology department of CHU-SO Lomé and diagnosed with SJS/TEN between 2000 and 2015.

Results: Records were identified for 14 children with these diagnoses during the study period. Read More

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http://dx.doi.org/10.1684/mst.2018.0797DOI Listing
May 2018
1 Read

Stevens-Johnson syndrome/toxic epidermal necrolysis in Jewish and Arab populations.

Epilepsia 2018 07;59(7):1469-1470

Institute for Drug Research, School of Pharmacy, The Hebrew University, Jerusalem, Israel.

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http://dx.doi.org/10.1111/epi.14437DOI Listing
July 2018
1 Read

Incidence of Stevens-Johnson syndrome following combination drug use of allopurinol, carbamazepine and phenytoin in Taiwan: A case-control study.

J Dermatol 2018 Sep 2;45(9):1080-1087. Epub 2018 Jul 2.

Department of Emergency Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.

The goal of our study was to investigate the incidence of Stevens-Johnson syndrome (SJS), the frequency of SJS diagnosis, and the association between SJS and prior use of allopurinol, carbamazepine or phenytoin. This case-control study utilized data from the National Health Insurance Research Database (NHIRD) of Taiwan. Controls visited the emergency department of the same hospital for trauma or fractures (excluding burns) and used allopurinol, carbamazepine or phenytoin during the past 3 months. Read More

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http://dx.doi.org/10.1111/1346-8138.14528DOI Listing
September 2018
8 Reads

Stevens-Johnsons syndrome or drug-induced lupus - a clinical dilemma: A case report and review of the literature.

Biomed Rep 2018 Jul 16;9(1):37-41. Epub 2018 May 16.

Department of Internal Medicine and Rheumatology, 'Sfanta Maria' Hospital, 011172 Bucharest, Romania.

Tumor necrosis factor inhibitors are the first biological agents used in the treatment of rheumatoid arthritis (RA) to have yielded satisfactory results in terms of clinical improvement and radiologic progression, but they are also associated with the possibility of occurrence of a number of autoimmune systemic events [drug-induced lupus (DIL), vasculitis, sarcoidosis] and localized adverse events [uveitis, psoriasis, interstitial lung disease, erythema multiforme including the major form Stevens-Johnson syndrome (SJS)]. During treatment with TNF inhibitors, many patients develop positivity for antinuclear, antihistone and anti-double stranded DNA antibodies, though only a minority of patients will develop clinical manifestations and approximately less than 1% will fulfill the classification criteria for systemic lupus erythematosus. Mucocutaneous manifestations are the most frequent manifestations of DIL following treatment with TNF inhibitors, and can be severe and occasionally difficult to differentiate from erythema multiforme/SJS. Read More

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http://www.spandidos-publications.com/10.3892/br.2018.1098
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http://dx.doi.org/10.3892/br.2018.1098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007037PMC
July 2018
10 Reads

Wound management strategies in Stevens-Johnson syndrome/toxic epidermal necrolysis: An unmet need.

Authors:
Haur Yueh Lee

J Am Acad Dermatol 2018 10 18;79(4):e87-e88. Epub 2018 Jun 18.

Department of Dermatology, Singapore General Hospital, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2018.05.1258DOI Listing
October 2018
1 Read

Reply to: "Wound management strategies in Stevens-Johnson syndrome/toxic epidermal necrolysis: An unmet need".

J Am Acad Dermatol 2018 10 18;79(4):e89. Epub 2018 Jun 18.

University of South Florida Health Morsani College of Medicine, Tampa, Florida. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2018.06.017DOI Listing
October 2018
2 Reads

Life-threatening dermatoses: Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. Impact on the Spanish public health system (2010-2015).

PLoS One 2018 18;13(6):e0198582. Epub 2018 Jun 18.

Instituto de investigación Biomédica de Salamanca, Salamanca, Spain.

Background: Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are serious mucocutaneous reactions. In Spain, the epidemiology and resulting expenses of these diseases are not well established.

Methodology: Retrospective descriptive study using the Minimum Basic Data Set (CMBD in Spanish) in patients admitted to hospitals of the National Health System between 2010 and 2015 with a diagnosis of SJS and TEN (combination of ICD-9 codes 695. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0198582PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005565PMC
January 2019
18 Reads

Procalcitonin as a diagnostic indicator for systemic bacterial infections in patients with Stevens-Johnson syndrome/toxic epidermal necrolysis.

J Dermatol 2018 Aug 13;45(8):989-993. Epub 2018 Jun 13.

Institute of Dermatology and Venereology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, China.

Elevated serum procalcitonin (PCT) level has been reported to be a diagnostic index in systemic bacterial infections, but it can also increase in some non-infectious inflammatory diseases. Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) is a rare immune-mediated cutaneous mucosal reaction which is susceptible to bacterial infections and may have elevated PCT levels. The value of serum PCT has not been assessed in series of SJS/TEN patients. Read More

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http://dx.doi.org/10.1111/1346-8138.14488DOI Listing
August 2018
1 Read
2.350 Impact Factor

Minimal clinically important differences for measures of treatment efficacy in Stevens-Johnson syndrome and toxic epidermal necrolysis.

J Am Acad Dermatol 2018 Dec 8;79(6):1150-1152. Epub 2018 Jun 8.

Division of Dermatology, Department of Medicine, University of Ottawa, Ottawa, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2018.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234072PMC
December 2018
1 Read

Clinical features of Stevens-Johnson syndrome and toxic epidermal necrolysis.

Pediatr Int 2018 Aug 30;60(8):697-702. Epub 2018 Jul 30.

Division of Infectious Diseases and Immunology, Saitama Children's Medical Center, Saitama, Japan.

Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare, but these conditions are associated with high mortality. There have been few reports of SJS and TEN in children. The aim of this study was to evaluate the clinical features and outcomes of SJS and TEN in a group of Japanese children. Read More

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http://dx.doi.org/10.1111/ped.13613DOI Listing
August 2018
14 Reads

Lenalidomide Induced Toxic Epidermal Necrolysis and Del (5q): Co-occurrence of Rarities.

J Coll Physicians Surg Pak 2018 Jun;28(6):S89-S90

Department of Hematology, Armed Forces Bone Marrow Transplant Centre, Rawalpindi.

Primary myelofibrosis (PMF) is a clonal, BCR-ABL1 negative myeloproliferative neoplasm characterised by splenomegaly, leukoerythroblastic peripheral blood picture and bone marrow fibrosis. Different cytogentic abnormalities are documented in PMF which have impact on clinical outcome and overall survival. Del 5q31 is documented in only 0. Read More

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http://dx.doi.org/10.29271/jcpsp.2018.06.S89DOI Listing
June 2018
15 Reads

Alopecia Areata-like Hair Loss Accompanying Toxic Epidermal Necrolysis.

Acta Derm Venereol 2018 Oct;98(9):906-907

Department of Dermatology, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyush, 807-8555, Japan, Japan.

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http://dx.doi.org/10.2340/00015555-2982DOI Listing
October 2018
4 Reads

Intravenous immunoglobulins in dermatology. Part 2: clinical indications and outcomes.

Clin Exp Dermatol 2018 Aug 17;43(6):659-666. Epub 2018 May 17.

Dermatological Surgery and Laser Unit, St John's Institute of Dermatology, Guy's Hospital Cancer Centre, Guy's and St Thomas' NHS Foundation Trust, Great Maze Pond, London, UK.

Intravenous immunoglobulin (IVIg) is a solution of human IgG, salt, sugars and solvents used to treat a multitude of diseases. Although IVIg has been known to treat many diseases safely and successfully, there are relatively few supporting randomized controlled trials. In part two of this review, we assess the clinical indications of IVIg in dermatological disorders and the outcomes of its use. Read More

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http://dx.doi.org/10.1111/ced.13552DOI Listing

Widespread Skin Necrosis Secondary to Gemcitabine Therapy.

J Drugs Dermatol 2018 May;17(5):582-585

Gemcitabine, a pyrimidine nucleoside analogue, is an oncologic agent used in the treatment of cutaneous T-cell lymphoma (CTCL). Common dermatologic reactions associated with gemcitabine include alopecia, mild skin rash, and mucositis but skin necrosis is exceptional. Herein we present an unusual case of widespread skin necrosis mimicking toxic epidermal necrolysis in a 45-year-old woman receiving gemcitabine therapy for stage IIIA cutaneous T-cell lymphoma. Read More

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May 2018
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The risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptic drugs: Comment on data sparsity.

Epilepsia 2018 05;59(5):1083-1084

Department of Epidemiology, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

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http://doi.wiley.com/10.1111/epi.14024
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http://dx.doi.org/10.1111/epi.14024DOI Listing
May 2018
4 Reads
4.570 Impact Factor

Response: The risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptic drugs: Comment on data sparsity.

Epilepsia 2018 05;59(5):1084-1085

Basel Pharmacoepidemiology Unit, Division of Clinical Pharmacy and Epidemiology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.

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http://dx.doi.org/10.1111/epi.14063DOI Listing
May 2018
1 Read

Sparse data and use of logistic regression.

Authors:
Prabha Siddarth

Epilepsia 2018 05;59(5):1085-1086

Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.

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http://dx.doi.org/10.1111/epi.14081DOI Listing
May 2018
1 Read

A recalcitrant case of toxic epidermal necrolysis.

Cutis 2018 Mar;101(3):E8-E10

Department of Dermatology, University of California School of Medicine, Irvine, USA.

We describe a case that was initially diagnosed and treated as toxic epidermal necrolysis (TEN) by an outside hospital. After failure to improve on high-dose steroids and intravenous (IV) immunoglobulin, the patient was transferred to our hospital where he was subsequently diagnosed with a disseminated herpes simplex virus (HSV) infection. The patient recovered after 21 days of antiviral therapy. Read More

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March 2018
2 Reads

[Treatment of severe cutaneous adverse drug reactions].

Ann Dermatol Venereol 2018 Jun - Jul;145(6-7):454-464. Epub 2018 Apr 13.

Service de dermatologie, hôpital Henri-Mondor, AP-HP, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94000 Créteil, France; Centre de référence des dermatoses bulleuses toxiques et toxidermies graves (filière FIMARAD), hôpital Henri-Mondor, AP-HP, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94000 Créteil, France.

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http://dx.doi.org/10.1016/j.annder.2018.02.014DOI Listing
January 2019
5 Reads

Association of HLA-A*31:01 Screening With the Incidence of Carbamazepine-Induced Cutaneous Adverse Reactions in a Japanese Population.

JAMA Neurol 2018 Jul;75(7):842-849

RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.

Importance: Carbamazepine, a commonly used antiepileptic drug, is one of the most common causes of cutaneous adverse drug reactions (cADRs) worldwide. The allele HLA-A*31:01 is reportedly associated with carbamazepine-induced cADRs in Japanese and European populations; however, the clinical utility of HLA-A*31:01 has not been evaluated.

Objective: To assess the use of HLA-A*31:01 genetic screening to identify Japanese individuals at risk of carbamazepine-induced cADRs. Read More

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http://dx.doi.org/10.1001/jamaneurol.2018.0278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145764PMC
July 2018
14 Reads

Histopathology of Cutaneous Inflammatory Disorders in Children.

Pediatr Dev Pathol 2018 Mar-Apr;21(2):115-149

1 Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri.

Inflammatory dermatoses encompass a variety of histologic patterns that affect different portions of the skin. In spongiotic, psoriasiform, lichenoid, pityriasiform, and blistering disorders, there are predominately epidermal and junctional activities with variable superficial dermal inflammation. Hypersensitivity reactions can show either epidermal or mostly dermal changes depending on whether the exposure of the exogenous allergen occurs through an external or internal route, respectively. Read More

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http://dx.doi.org/10.1177/1093526617748781DOI Listing
April 2018
7 Reads

The Epidemiology of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in China.

J Immunol Res 2018 11;2018:4320195. Epub 2018 Feb 11.

Department of Dermatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.

Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are life-threatening disease. However, there are only few epidemiologic studies of SJS/TEN from China. To analyze the clinical characteristics, causality, and outcome of treatment for SJS/TEN in China, we reviewed case reports of patients with SJS/TEN from the China National Knowledge Infrastructure (CNKI) and Wanfang database from 2006 to 2016 and patients with SJS/TEN who were admitted to the First Affiliated Hospital of Fujian Medical University during the same period. Read More

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http://dx.doi.org/10.1155/2018/4320195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828103PMC
September 2018
2 Reads

Wound care for Stevens-Johnson syndrome and toxic epidermal necrolysis.

J Am Acad Dermatol 2018 Oct 27;79(4):764-767.e1. Epub 2018 Mar 27.

University of South Florida Health Morsani College of Medicine, Tampa, Florida. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2018.03.032DOI Listing
October 2018
2 Reads

Selected presentations of lip enlargement: clinical manifestation and differentiation.

Postepy Dermatol Alergol 2018 Feb 20;35(1):18-25. Epub 2018 Feb 20.

Department of Oral Surgery, Poznan University of Medical Sciences, Poznan, Poland.

Lip enlargement may be an important symptom of either systemic or local diseases. On the basis of selected age-matched clinical cases we present the possible causes of lip swelling. We describe the most representative symptoms and recommend treatment of these pathologies. Read More

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http://dx.doi.org/10.5114/ada.2018.73160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872243PMC
February 2018
4 Reads

Stevens-Johnson syndrome and toxic epidermal necrolysis-like cutaneous presentation of chikungunya fever: A case series.

Pediatr Dermatol 2018 May 24;35(3):392-396. Epub 2018 Mar 24.

Department of Pediatrics, Lady Hardinge Medical College and Associated Hospitals, New Delhi, India.

Chikungunya fever is a benign, self-limiting, acute viral illness. An epidemic occurred in New Delhi, India, in August and September 2016. We observed many cases with atypical cutaneous features mimicking Stevens-Johnson syndrome and toxic epidermal necrolysis during this epidemic, especially in infants and children. Read More

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http://dx.doi.org/10.1111/pde.13450DOI Listing
May 2018
9 Reads
1.520 Impact Factor