41,135 results match your criteria Erythema Multiforme Stevens-Johnson Syndrome
J Biomed Opt 2018 Dec;23(12):1-11
Tufts University, Biomedical Engineering, Medford, Massachusetts, United States.
Optical spectral images can be used to estimate the amount of bulk absorbers in tissues, specifically oxy- and deoxyhemoglobin, as well as scattering parameters. Most systems that capture spectral image data are large, heavy, and expensive. This paper presents a full end-to-end analysis of a low-cost reflectance-mode multispectral imaging system operating in the visible and near-infrared spectra. Read More
G Ital Dermatol Venereol 2018 12;153(6):855-859
Department of Clinical Pathology Cristo Re Hospital, Rome, Italy.
Background: Atopic dermatitis (AD) is a chronic, recurrent, inflammatory skin disorder which may persist or directly start in adults. This is an open-label prospective study to clinically and instrumentally evaluate the effects of an emollient glycerin and paraffin-based cream and a gentle refatting cleanser in the management of mild to moderate adulthood AD.
Methods: Fifty adult patient with mild to moderate AD were recruited at the Professional Dermatology and Allergology Outpatient Clinic of the San Gallicano Dermatological Institute of Rome, between November 2016 and January 2018. Read More
J Vet Pharmacol Ther 2018 Dec 2. Epub 2018 Dec 2.
Kindred Biosciences, Inc., Burlingame, California.
Mirtazapine is classified as a weight gain drug in cats, and the purpose of this study was to evaluate its efficacy in cats experiencing unintended weight loss. This was a multi-center, double-blind, placebo-controlled, randomized clinical study in client-owned cats ≥1 year of age, weighing ≥2 kg, with a documented loss (≥5%) in body weight. Cats were treated once daily with either 2 mg/cat mirtazapine transdermal ointment (n = 83) or placebo (n = 94) (Per Protocol population) applied to the inner surface of the pinna for 14 ± 3 days. Read More
Indian Dermatol Online J 2018 Nov-Dec;9(6):414-417
Department of Dermatology, AIIMS, Raipur, India.
Background: Pityriasis rosea (PR) is a common, self-limiting dermatologic disorder. The information regarding the clinical profile of the disease in India is limited because of inadequate studies.
Materials And Methods: A retrospective, record-based study on the clinical presentation of PR was conducted in a tertiary care center based in Central India. Read More
Indian Dermatol Online J 2018 Nov-Dec;9(6):389-393
Department of Dermatology, Venereology and Leprosy, RNT Medical College, Udaipur, Rajasthan, India.
Background: Recently, with better understanding of the immunology of warts, immunotherapeutic approaches have emerged as an effective treatment option for the management of cutaneous warts. Intralesional immunotherapy with MMR vaccine is one such modality but there are still lack of enough placebo-controlled studies.
Aim: To evaluate the efficacy of intralesional MMR in patients of extragenital warts in a double-blinded manner using normal saline as control. Read More
Indian J Dermatol 2018 Nov-Dec;63(6):465-468
Department of Pathology and Lab Medicine, AIIMS, Bhopal, Madhya Pradesh, India.
Background: Hansen's disease is a chronic infectious disease caused by . It is characterized by a wide range of clinical and histological manifestations. Ridley-Jopling criteria are widely used for classifying leprosy. Read More
Anticancer Res 2018 Dec;38(12):6927-6930
Division of Hematology Oncology, David Geffen School of Medicine and University of California, Los Angeles, CA, U.S.A.
Background: Liposomal formulation of anthracyclines provide better systemic and organ-specific tolerance, with potential for less local tissue damage during extravasation. Several small series have reported that most liposomal anthracycline extravasations are consistent with irritant injury without tissue necrosis. There have been no reports published regarding the clinical effects of extravasation of liposomal cytarabine-daunorubicin (CPX-351). Read More
Rev Lat Am Enfermagem 2018 Nov 29;26:e3075. Epub 2018 Nov 29.
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Ribeirão Preto, SP, Brazil.
Objective: to evaluate the safety of a topical formulation containing chamomile microparticles coated with chitosan in the skin of healthy participants.
Method: phase I blind, controlled, non-randomized, single-dose clinical trial with control for skin, base formulation, and formulation with microparticles. The variables analyzed were irritation and hydration by the Wilcoxon and Kruskall-Wallis tests. Read More
J Oncol Pharm Pract 2018 Dec 4:1078155218816768. Epub 2018 Dec 4.
1 Division of Medical Oncology and Hematology, Kobe University Hospital, Kobe, Hyogo, Japan.
A 69-year-old woman who had been diagnosed with unresectable papillary thyroid cancer was referred to our hospital. We initially treated her with sorafenib, but she subsequently developed erythema multiforme, which was suspected to be a drug rush due to sorafenib; therefore, sorafenib was discontinued. At the time of discontinuation, immature blast cells were detected in her peripheral blood. Read More
J Clin Med 2018 Dec 2;7(12). Epub 2018 Dec 2.
Department of Infectious Diseases, University Medical Center Ljubljana, Japljeva 2, 1525 Ljubljana, Slovenia.
Infected elderly people often present with signs and symptoms that differ from those in younger adults, but data on the association between patient age and presentation of early Lyme borreliosis (LB) are limited. In this study, the association between patient age (18⁻44 years, young vs. 45⁻64 years, middle-aged vs. Read More
South Med J 2018 Dec;111(12):716-720
From the Division of Emergency Medicine, Washington University School of Medicine, St Louis, Missouri, the Division of Emergency Medicine, Duke University, Durham, North Carolina, the Department of Emergency Medicine, East Carolina University Brody School of Medicine, Greenville, North Carolina, the Department of Emergency Medicine, Virginia Commonwealth University, Richmond, the Department of Emergency Medicine, Baylor College of Medicine, Houston, Texas, the Department of Emergency Medicine, University of North Carolina, Chapel Hill, North Carolina, Texas A&M Health Sciences Center, Bryan, Rocky Mountain Poison & Drug Center, Denver, Colorado, the Department of Emergency Medicine, UT Southwestern Medical Center, Dallas, Texas, the Department of Emergency Medicine, Augusta University, Augusta, Georgia, the Department of Emergency Medicine, University of Virginia, Charlottesville, the Department of Surgery, East Carolina University Brody School of Medicine, Greenville, North Carolina, and the Department of Surgery, Marshall University, Huntington, West Virginia.
Objective: To compare the incidence of hypersensitivity reactions following copperhead envenomation treated with Fab antivenom (FabAV) or placebo.
Methods: Patients with copperhead snakebites received treatment and follow-up in a prospective, randomized, double-blind, placebo-controlled trial of FabAV or placebo. The treatment allocation ratio was 2:1 (FabAV:placebo). Read More
J Drugs Dermatol 2018 Nov;17(11):1201-1208
Background: Rosacea is a chronic dermatologic condition with limited treatment options. Methods: Data were pooled from two identically designed phase 3 trials. Patients with moderate to severe persistent erythema of rosacea were randomized to receive oxymetazoline cream 1. Read More
J Drugs Dermatol 2018 Nov;17(11):1178 - 1182
Purpose: Fractionated carbon dioxide (CO2) laser resurfacing uses fractional photothermolysis with an ablative 10,600-nm wavelength for treatment of rhytides and photodamage. Although associated with reduced side effect profile from traditional ablative lasers, fractionated lasers can lead to significant erythema, edema, crusting, and exudation for 14 days. Post-care includes regular distilled water soaks and healing ointment. Read More
JBRA Assist Reprod 2018 Nov 30. Epub 2018 Nov 30.
Reproductive Endocrinology and Infertility, New Hope Fertility Center, New York, NY.
Some of the common side effects of the injectable gonadotropins, used during fertility treatments, are pain at the injection site, skin erythema, muscle pain, and rarely vasovagal reflex. These side effects cause inconvenience and lower patient's tolerance for fertility treatments.The purpose of this study was to evaluate the safety and efficacy of an FDA-approved dose of nasal human menopausal gonadotropins (Menopur) in women undergoing fertility treatment. Read More
Br J Dermatol 2018 Nov 30. Epub 2018 Nov 30.
Allergan plc, Irvine, CA.
Background: Once-daily topical oxymetazoline cream 1.0% significantly reduced persistent facial erythema of rosacea in trials requiring live, static patient assessments.
Objective: To critically evaluate the methodology of clinical trials that require live, static patient assessments by determining whether assessment of erythema is different when reference to the baseline photograph is allowed. Read More
Eur J Rheumatol 2018 Oct 12. Epub 2018 Oct 12.
Division of Rheumatology, Department of Internal Medicine, Dokuz Eylül University School of Medicine, İzmir, Turkey.
Objective: Familial Mediterranean fever (FMF) is the most common autoinflammatory disease. Most of the identified disease-causing mutations are located on exon 10. As the number of studies about the effect of the exonal location of the mutation and its phenotypic expression is limited, we aimed to investigate whether the exonic location of the Mediterranean fever (MEFV) mutation has an effect on the clinical manifestation in patients with FMF. Read More
Vasc Endovascular Surg 2018 Nov 28:1538574418814058. Epub 2018 Nov 28.
1 Division of Transplantation and Vascular surgery, Department of Surgery, Dongsan Medical Center, Keimyung University, Daegu, Korea.
Late occurrence of arterial aneurysms following ligation of a hemodialysis arteriovenous fistula (AVF) is rare. Here, we report the case of 51-year-old male patient with an AVF in which arterial aneurysms developed. The patient had undergone left arm radiocephalic (RC) AVF creation for hemodialysis in 2000. Read More
Int Forum Allergy Rhinol 2018 Nov 28. Epub 2018 Nov 28.
Department of Otorhinolaryngology, Mayo Clinic, Phoenix, AZ.
Background: Signs of inflammation are commonly encountered during endoscopic examination of the Eustachian tube (ET) region. The clinical applicability of these findings may be enhanced by use of a standardized assessment score.
Methods: Digital video recordings were obtained of 50 nasal endoscopy examinations of the nasopharyngeal portion of the ET. Read More
An Bras Dermatol 2018 Nov/Dec;93(6):887-889
Department of Dermatology and Venereology, Hospital Santo António dos Capuchos, Centro Hospitalar de Lisboa Central, Lisbon, Portugal.
Nodular vasculitis is an uncommon type of panniculitis. It was firstly associated to the infection by Mycobacterium tuberculosis and named erythema induratum of Bazin, however nowadays it has been associated with several other underlying disorders and it is better described as nodular vasculitis. Concerning its relationship with malignant conditions, there is only one reported case, in association with metastatic colon adenocarcinoma. Read More
An Bras Dermatol 2018 Nov/Dec;93(6):874-877
Department of Pathology, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Autoimmune progesterone dermatitis is an uncommon, poorly recognized and under-diagnosed catamenial dermatosis associated with hypersensitivity reactions to progestagens. Most cases manifest as urticaria, eczema or erythema multiforme-like. A 26-year-old woman developed violaceous plaques on the groin and abdomen, 4 days after a spontaneous abortion resolved with uterine curettage. Read More
Int J STD AIDS 2018 Nov 27:956462418805197. Epub 2018 Nov 27.
1 Dermatology Hospital of Southern Medical University (Guangdong Provincial Dermatology Hospital), Guangzhou, China.
Early syphilis can rarely cause erythema multiforme-type eruptions as well as triggering erythema multiforme (EM). EM-like lesions in secondary syphilis are characterized by clinical features of EM and laboratory tests consistent with secondary syphilis and the skin histology shows predominantly a plasma cell infiltrate with the presence of treponemes. When EM is triggered by early syphilis, the skin histology shows mixed inflammatory cells usually in the absence of treponemes in the skin lesion. Read More
J Drugs Dermatol 2018 Nov;17(11):1157 - 1162
OBJECTIVE: The aim of this study was to evaluate the incidence of adverse effects following laser skin resurfacing with the microablative carbon dioxide (CO2) laser system (SmartXide DOT; DEKA, Calenzano, Italy). METHODS: A retrospective chart review was performed. Data was collected for DOT laser procedures performed at three clinical centers from 2008-2014. Read More
Hum Vaccin Immunother 2018 Nov 27. Epub 2018 Nov 27.
c Sanofi Pasteur MSD , Lyon , France.
This randomized trial conducted in France compared intramuscular (IM) and subcutaneous (SC) administration of two doses of a measles, mumps, rubella, and varicella (MMRV) combination vaccine (ProQuad®) administered one month apart to 405 children 12-18 months of age (NCT00402831). The 2-dose regimen of MMRV administered IM was shown to be as immunogenic as the 2-dose regimen administered SC for all antigens 6 weeks post-vaccination for the subjects who were initially seronegative for measles, mumps, rubella, or varicella (lower bounds of the two-sided 95% CIs for the difference in response rates for all antigens greater than -10% [range -2.1 for varicella to -3. Read More
Lasers Surg Med 2018 Nov 27. Epub 2018 Nov 27.
Syneron-Candela Corporation, Wayland, Massachusetts.
Objectives: The pulsed-dye laser has long been a gold standard in the treatment of poikiloderma of Civatte. Recent advances in pulsed dye laser technology enable output energies 50% higher, enabling beam diameters of up to 15 mm with clinically relevant fluences. In this study, we investigate this new laser for treatment of this condition. Read More
Lasers Surg Med 2018 Nov 27. Epub 2018 Nov 27.
Department of Dermatology, University of California San Diego, La Jolla 92122, California.
Benign pigmented lesions are among the most common dermatologic diagnoses that patients seek treatments for. Treatment modalities range from cryotherapy to light and laser-based technologies. These treatments have been shown to be effective, yet may lead to dyschromia or significant downtime. Read More
Scars Burn Heal 2018 Jan-Dec;4:2059513118808773. Epub 2018 Nov 18.
Centre for Cutaneous Research, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, UK.
Introduction: Autologous platelet-based concentrates represent increasingly popular adjuncts to a variety of medical, surgical and aesthetic interventions. Their beneficial potential rests on the ability to deliver a high concentration of growth factors to the target tissues. There are currently no reports in the literature appraising the evidence behind the use of platelet-rich plasma (PRP) in scar management. Read More
Radiol Case Rep 2019 Feb 16;14(2):238-241. Epub 2018 Nov 16.
Department of Radiology, University of Kansas Medical Center, 3901 Rainbow Boulevard, MS 4032, Kansas City, KS 66160, USA.
We report a case of intratendinous patellar abscess and prepatellar septic bursitis following direct inoculation in a 26-year-old male injection drug user. The patient presented with 2 days of progressive knee pain, swelling, and erythema. Computed tomography demonstrated an enlarged patellar tendon with central low attenuation. Read More
Int J Nurs Knowl 2018 Nov 26. Epub 2018 Nov 26.
the School of Nursing, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Purpose: To assess the surgical wound (SW) healing in orthopedic patients with Impaired tissue integrity according to the Nursing Outcomes Classification (NOC).
Methods: A prospective longitudinal study performed with 24 patients. Data collection was performed through an instrument containing the NOC indicators. Read More
JAMA Dermatol 2018 Nov 21. Epub 2018 Nov 21.
Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.
J Dermatol 2018 Nov 26. Epub 2018 Nov 26.
Departments of Dermatology, Teikyo University School of Medicine, Tokyo, Japan.
Generalized pustular psoriasis (GPP) is a systemic inflammatory disease that presents with erythema and sterile pustules, pathologically characterized by Kogoj's spongiform pustules. GPP is sometimes accompanied by mucosal involvement, and the most common lesion is on the tongue. IL36RN mutation was found to contribute to the pathogenesis of GPP especially in patients who develop GPP without a past medical history of psoriasis vulgaris. Read More
J Eur Acad Dermatol Venereol 2018 Nov 25. Epub 2018 Nov 25.
Dermatology, Department of Specialized, Diagnostic and Experimental Medicine, University of Bologna, Italy.
Background: Frontal fibrosing alopecia (FFA) is increasing in prevalence worldwide and several series from different countries have been published, in order to detect possible causes of the disease outbreak.
Objective: To analyze the epidemiological, clinical and trichoscopic features of FFA seen in an Italian Dermatology Unit.
Methods: Clinical, trichoscopy, histopathology and medical details of all patients were compared with literature and general population data. Read More
Arch Dis Child 2018 Nov 24. Epub 2018 Nov 24.
School of Medicine and Health Sciences, University of Papua New Guinea, Port Moresby, Papua New Guinea.
In low-income and middle-income countries, courses of antibiotics are routinely given to term newborns whose mothers had prolonged rupture of membranes (PROM). Rational antibiotic use is vital given rising rates of antimicrobial resistance and potential adverse effects of antibiotic exposure in newborns. However missing cases of sepsis can be life-threatening. Read More
Photodiagnosis Photodyn Ther 2018 Nov 20. Epub 2018 Nov 20.
Dermatology Department, University General Hospital of Valencia, Valencia, Spain.
Background: Idiopathic pulmonary fibrosis (IPF) is an idiopathic interstitial progressive fibrotic lung disease and the most lethal of all interstitial lung diseases. Pirfenidone is a novel antifibrotic and anti-inflammatory agent which reduces decline in lung function and prolonges progression-free survival. It has a favourable benefit-risk profile and is generally well tolerated. Read More
Drug Test Anal 2018 Nov 23. Epub 2018 Nov 23.
Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstraße 11, 80937, Munich, Germany.
Exposure to the vesicant sulfur mustard (SM) may lead to erythema and blistering. Toxicity of SM is hypothesized to be due to the alkylation of DNA bases and nucleophilic amino acid side chains in proteins (adducts) by forming the hydroxyethylthioethyl (HETE) moiety. Despite of its prohibition by the chemical weapons convention, SM still represents a serious threat to military personnel and civilians. Read More
Int J Nanomedicine 2018 6;13:7155-7166. Epub 2018 Nov 6.
The 5th Department (Internal Medicine I), Faculty of Medicine, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
Purpose: Red chili peppers have been highly valued in gastronomy and traditional medicine since ancient times; it seems that it is not just an ingredient for food but also a good remedy for various medical conditions such as increased blood pressure and high levels of serum triglycerides and cholesterol, myocardial infarction, arthritis, and migraines. The objective of this study is the characterization of a new carrier used for encapsulated extract.
Methods: Chili pepper extract was obtained and was physically entrapped inside polyurethane microparticles in order to diminish the irritative potential of this extract. Read More
Dermatology 2018 Nov 21:1-7. Epub 2018 Nov 21.
Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.
Objectives: Potassium iodide (KI) is a medication that has been used for decades in dermatology and it is mentioned as a treatment option in all major dermatology textbooks. Yet, there is little recent information on its efficacy. In our study, we wanted to retrospectively evaluate the therapy response to KI in our patients. Read More
Clin Exp Dermatol 2018 Nov 20. Epub 2018 Nov 20.
Department of Dermatology, Fukushima Medical University, Hikarigaoka 1, Fukushima, 960 1295, Japan.
Dis Aquat Organ 2018 Nov;131(3):167-176
Rescue and Rehabilitation Department, New England Aquarium, Boston, MA 02110, USA.
There has been an increase in the presence of alopecia among gray seals Halichoerus grypus atlantica in Massachusetts, USA. To understand the prevalence and describe the presentation of this condition, data records and photographs of 10070 gray seals from 2004-2013 were reviewed; there were sufficient data to confidently assess the presence or absence of alopecia in 2134 seals. Mild hair loss presented in multifocal patches with minimal to no skin lesions or erythema. Read More
Turk J Gastroenterol 2018 Nov 19. Epub 2018 Nov 19.
Department of Pathology, Necmettin Erbakan University School of Medicine, Konya, Turkey.
Fixed drug eruption (FDE) is a type of drug reaction characterized by localized erythema, hyperpigmentation, and bullous at the same site(s), generally observed following every intake of a causative drug. Delayed-type cellular hypersensitivity (Type IVC) is considered to play a role in FDE etiology. Several antibiotics, barbiturates, oral contraceptives, nonsteroidal anti-inflammatory drugs, laxative-containing phenolphthalein, metronidazole, and quinine are known to be the primary drugs responsible for FDE. Read More
Arthritis Res Ther 2018 Nov 20;20(1):257. Epub 2018 Nov 20.
Department of Immunology and Rheumatology, Unit of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
Background: We showed previously that Japanese individuals with familial Mediterranean fever (FMF) have a more atypical phenotype compared to endemic areas. The clinical differences between young-onset FMF (YOFMF), adult-onset FMF (AOFMF), and late-onset FMF (LOFMF) in Japan are unclear.
Methods: We enrolled 395 consecutive patients. Read More
BMC Cancer 2018 Nov 20;18(1):1142. Epub 2018 Nov 20.
Department of Gastroenterology, University of Tsukuba Hospital, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
Background: Anal canal cancer occasionally accompanies extramammary Paget disease. Although most of them are squamous cell carcinoma, anal canal adenocarcinoma with neuroendocrine features accompanying secondary extramammary Paget disease has never been reported.
Case Presentation: Here, we report a 76-year-old man presented with pruritus in the perianal area. Read More
J Cosmet Dermatol 2018 Nov 19. Epub 2018 Nov 19.
Tennessee Clinical Research Center, Nashville, Tennessee.
Background: Skincare cosmeceutical products have been shown to address intrinsic and extrinsic skin aging. Radiofrequency (RF) with microneedling is effective and safe in improving skin laxity and texture. Pairing skincare cosmeceutical products pre- and post-procedure is beneficial as it enhances patient results, patient results, patient experience, and reduces patient downtime. Read More
Eur J Clin Microbiol Infect Dis 2018 Nov 19. Epub 2018 Nov 19.
University Hospital "Dr. Jose Eleuterio Gonzalez", Department of Dermatology, Universidad Autonoma de Nuevo Leon, Av. Madero y Gonzalitos s/n, Colonia Mitras Centro, 64460, Monterrey, NL, Mexico.
Lyme disease (borreliosis) is one of the most common vector-borne diseases worldwide. Its incidence and geographic expansion has been steadily increasing in the last decades. Lyme disease is caused by Borrelia burgdorferi sensu lato, a heterogeneous group of which three genospecies have been systematically associated to Lyme disease: B. Read More
JAAD Case Rep 2018 Nov 10;4(10):1049-1051. Epub 2018 Nov 10.
Department of Dermatology, University of California, San Francisco, San Francisco, California.
JAAD Case Rep 2018 Nov 10;4(10):1024-1026. Epub 2018 Nov 10.
Department of Dermatology, University of Mississippi Medical Center, Jackson, Mississippi.
JAAD Case Rep 2018 Nov 9;4(10):1010-1013. Epub 2018 Nov 9.
Department of Dermatology, the University of California, Irvine, California.
Plast Surg (Oakv) 2018 Nov 18;26(4):250-255. Epub 2018 Jan 18.
Department of Plastic Surgery, Assaf Harofeh Medical Center, Tzrifin, Israel.
Background: Phenol chemical peeling (PCP) treatment is associated with prolonged recovery and sustained adverse events. Hyperbaric oxygen therapy (HBOT) is known to accelerate wound healing. The purpose of the current study was to evaluate the effect of HBOT on PCP recovery period and adverse events. Read More
J Cutan Med Surg 2018 Nov 18:1203475418814229. Epub 2018 Nov 18.
3 Faculty of Medicine, University of Toronto, ON, Canada.
Background:: Current knowledge of the efficacy and safety of ixekizumab is limited to data from phase III randomized controlled trials (RCTs). A gap exists in our understanding of treatment outcomes of this newly available biologic in real-world clinical practice.
Objective:: This study explores the efficacy and safety of ixekizumab in non-RCT patients to compare real-world outcomes to those reported in RCTs. Read More
Eur J Pediatr 2018 Nov 17. Epub 2018 Nov 17.
Department of Dermatology, UZ Leuven Campus Gasthuisberg, Herestraat 49, 3000, Leuven, Belgium.
A retrospective study in which we reviewed the hospital files of a subset of 7 patients with Duchenne muscular dystrophy participating in the open-label phase I/II PRO051-02 study in Leuven. The objective of this study was to describe in detail the injection site reactions in these children treated with drisapersen (PRO-051), a 2'-O-methyl phosphorothioate RNA antisense oligonucleotide, that induces exon 51 skipping in Duchenne muscular dystrophy. Antisense oligonucleotides, restoring the reading frame by skipping of exons, have become a potential treatment of Duchenne muscular dystrophy and other monogenetic diseases. Read More