9,138 results match your criteria Erythema Multiforme


Genetic markers for methazolamide-induced Stevens-Johnson syndrome and toxic epidermal necrolysis.

J Eur Acad Dermatol Venereol 2022 06;36(6):764

Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

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Case Series of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis With Nivolumab and Nivolumab/ Ipilimumab Combination Therapy in Metastatic Melanoma.

J Drugs Dermatol 2022 May;21(5):529-530

Nivolumab (anti PD-1 antibody) and ipilimumab (anti CTLA-4 antibody) are immune checkpoint inhibitors (ICI) that effectively stimulate the native T cell response and lead to an antitumor response. The medications have been approved for the treatment of metastatic melanoma. However, ICIs are associated with higher risk for cutaneous immune-related adverse events (irAEs). Read More

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[Translated article] Use of Intravenous Immunoglobulins and Systemic Corticosteroids in Patients With Toxic Epidermal Necrolysis: Experience of a Hospital in Mexico City.

Actas Dermosifiliogr 2022 Mar 8;113(3):T294-T299. Epub 2022 Feb 8.

División de Dermatología, Hospital General Dr. Manuel Gea González, Ciudad de México, Mexico.

Toxic epidermal necrolysis is the most serious mucocutaneous adverse drug reaction. Multidisciplinary treatment and withdrawal of the causative drug are key to reducing mortality. Few studies have analyzed the use of systemic corticosteroids and intravenous immunoglobulins (IVIG) in patients with toxic epidermal necrolysis in Latin America. Read More

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Use of Intravenous Immunoglobulins and Systemic Corticosteroids in Patients with Toxic Epidermal Necrolysis: Experience of a Hospital in Mexico City.

Actas Dermosifiliogr 2022 Mar 10;113(3):294-299. Epub 2021 Nov 10.

División de Dermatología, Hospital General Dr. Manuel Gea González, Ciudad de México, México.

Toxic epidermal necrolysis is the most serious mucocutaneous adverse drug reaction. Multidisciplinary treatment and withdrawal of the causative drug are key to reducing mortality. Few studies have analyzed the use of systemic corticosteroids and intravenous immunoglobulins (IVIG) in patients with toxic epidermal necrolysis in Latin America. Read More

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Duloxetine-Associated Photodistributed Erythema Multiforme.

Prim Care Companion CNS Disord 2022 May 5;24(3). Epub 2022 May 5.

Department of Dermatology, Hospital General de México, Mexico City, Mexico.

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Erythema multiforme as a consequence of COVID-19 infection.

Dermatol Online J 2021 Dec 15;27(12). Epub 2021 Dec 15.

Lake Erie College of Osteopathic Medicine, Bradenton, Florida, USA.

Cutaneous manifestations of the 2019 coronavirus disease (COVID-19) are diverse and may be the only clinical evidence of infection, particularly in children [1]. The authors report a 10-year-old girl with erythematous vesicular papules and targetoid lesions of the extremities two weeks after polymerase chain reaction (PCR) confirmed severe acute respiratory syndrome coronavirus two (SARS-COV-2) infection. Biopsy depicted classic erythema multiforme (EM) and serology confirmed positive COVID-19 antibodies. Read More

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December 2021

Rare case of Stevens-Johnson syndrome with bronchiolitis obliterans as a chronic complication.

BMJ Case Rep 2022 Apr 25;15(4). Epub 2022 Apr 25.

Department of Pediatrics, Osaka Red Cross Hospital, Osaka, Japan.

A young girl in her teens presented with fever, rashes and various mucocutaneous symptoms. Flat erythematous macules were seen mainly on the limbs, without blisters or skin detachments. The lips were swollen with crusts and haemorrhage. Read More

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Matrix metalloproteinase 9 is associated with conjunctival microbiota culture positivity in Korean patients with chronic Stevens-Johnson syndrome.

BMC Ophthalmol 2022 Apr 19;22(1):179. Epub 2022 Apr 19.

Laboratory of Ocular Regenerative Medicine and Immunology, Seoul Artificial Eye Center, Seoul National University Hospital Biomedical Research Institute, Seoul, Republic of Korea.

Background: Stevens-Johnson syndrome (SJS) is an abnormal immune-response causing extensive exfoliation of the mucocutaneous tissue including conjunctiva. While several factors are associated with the alteration of conjunctival microbiota, the conjunctiva of SJS patients are found to harbor a different microbiota compared to healthy subjects. We investigated the conjunctival microbiota of Korean SJS patients, and identified factors associated with the conjunctival microbiota and its positive culture. Read More

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Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in the Era of Systems Medicine.

Methods Mol Biol 2022 ;2486:37-54

Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou, Taipei, and Keelung, Taiwan.

Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are severe mucocutaneous bullous disorders characterized by widespread skin and mucosal necrosis and detachment, which are most commonly triggered by medications. Despite their rarity, these severe cutaneous adverse drug reactions will result in high mortality and morbidity as well as long-term sequela. The immunopathologic mechanisms is mainly cell-mediated cytotoxic reaction against keratinocytes leading to massive skin necrolysis. Read More

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Erythema Multiforme after BNT162b2 Vaccination.

Intern Med 2022 Apr 16. Epub 2022 Apr 16.

Department of Dermatology, Chitose City Hospital, Japan.

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Urticarial vasculitis: Clinical and laboratory findings with a particular emphasis on differential diagnosis.

J Allergy Clin Immunol 2022 Apr;149(4):1137-1149

Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy; Internal Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. Electronic address:

Urticarial vasculitis (UV) is a rare cutaneous vasculitis of small vessels characterized by recurrent episodes of wheal-like lesions that tend to last more than 24 hours, healing with a residual ecchymotic postinflammatory hyperpigmentation. The histopathologic pattern of UV is that of leukocytoclastic vasculitis, consisting of fibrinoid necrosis of dermal vessels' walls and neutrophil-rich perivascular inflammatory infiltrates. Although its etiopahogenesis remains still undefined, UV is now regarded as an immune complex-driven disease with activation of the complement cascade, leading to exaggerated production of anaphylatoxins that are responsible for neutrophil recruitment and activation. Read More

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Coexistence of primary erythema migrans and erythema multiforme in early Lyme disease.

Indian J Dermatol Venereol Leprol 2022 May-Jun;88(3):396-398

Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.

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Sterile Neutrophilic Dermatosis (Sweet's Syndrome) Associated With Systemic Inflammatory Response Syndrome in a Maltese Dog: A Case Report.

Front Vet Sci 2022 21;9:837942. Epub 2022 Mar 21.

College of Veterinary Medicine, Gyeongsang National University, Jinju, South Korea.

We report a rare case of sterile neutrophilic dermatosis (Sweet's syndrome) accompanied by systemic inflammatory response syndrome. A 5-year-old, neutered male Maltese dog presented with extensive crusts on the whole-body surface and multifocal erosions and plaques on the four limbs. The lesions had been present for two months and did not respond to antibiotics before the presentation. Read More

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Cutaneous side effects and types of dermatological reactions in metastatic melanoma patients treated by immunotherapies or targeted therapies: A retrospective single center study.

Dermatol Ther 2022 Apr 5:e15492. Epub 2022 Apr 5.

Department of Medical Sciences, Dermatologic Clinic, University of Turin, Torino, Italy.

Immunotherapy and target therapy have revolutionized treatment of stage III/IV melanoma. Both treatments show a favorable toxicity profile even if cutaneous adverse events (AEs) are frequent (30%-40% of cases). This is a retrospective single center cohort study that included patients with stage IV or inoperable stage III metastatic melanoma (AJCC 8th) who received BRAFi + MEKi therapy or immunotherapy with Checkpoint inhibitors. Read More

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Undiagnosed and Rare Diseases in Critical Care: Severe Mucocutaneous Medication Reactions.

Crit Care Clin 2022 Apr;38(2):243-269

Department of Dermatology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA; Department of Pediatrics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.

There have been major advances in the understanding of severe cutaneous adverse reactions (SCARs). Early recognition and withdrawal of culprit medications can decrease morbidity and mortality significantly. SCARs encompass a variety of entities that present with extensive mucocutaneous involvement and systemic symptoms, often requiring management in an intensive care setting. Read More

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Pembrolizumab-induced Toxic Epidermal Necrolysis in a Patient with Metastatic Esophageal Adenocarcinoma.

R I Med J (2013) 2022 04 1;105(3):34-36. Epub 2022 Apr 1.

Brown Dermatology, Warren Alpert Medical School of Brown University, Providence, Rhode Island.

Adverse cutaneous reactions associated with the immune checkpoint inhibitor (ICI) pembrolizumab are well documented, yet life-threatening reactions such as Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) are infrequent.1,2 We present a case of pembrolizumab-induced TEN in a patient with metastatic esophageal adenocarcinoma who was successfully treated with cyclosporine and systemic corticosteroids. Read More

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Virological Characterization of Pigs with Erythema Multiforme.

Microorganisms 2022 Mar 18;10(3). Epub 2022 Mar 18.

Institute of Virology, Free University Berlin, 14163 Berlin, Germany.

Erythema multiforme in pigs is an acute, self-limiting disease characterized by red skin areas and often associated with anorexia, fever and respiratory problems. The cause of the disease remains unknown. In a recent study, animals of a commercial breeding herd in Greece were examined, and all animals were found seropositive for porcine reproductive and respiratory syndrome virus (PRRSV). Read More

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Oral erythema multiforme after Pfizer-BioNTech COVID-19 vaccination: a report of four cases.

BMC Oral Health 2022 03 24;22(1):90. Epub 2022 Mar 24.

Interdisciplinary Department of Medicine, University of Bari "Aldo Moro", Bari, Italy.

Background: The 2019 Coronavirus disease (Covid-19) has affected thousands of people worldwide. To date, vaccines appear to be the only method to prevent and reduce mortality. Four vaccinations have been outwardly approved by European Medicine Agency (EMA) in Europe: BNT162b2 (Comirnaty-BioNTech/Pfizer), mRNA-1273 (Spikevax-Moderna), ChAdOx1 (VaxzevriaAstrazeneca), and Ad26. Read More

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Pearls for the diagnosis and possible pathophysiological mechanisms of valproic acid-induced lupus erythematosus: A literature review.

Lupus 2022 May 24;31(6):650-658. Epub 2022 Mar 24.

Pulmonology Department NHS, 37794General Hospital of Thessaloniki "G. Papanikolaou", Thessaloniki, Greece.

Drug-induced lupus erythematosus (DILE) accounts for 10-15% of systemic lupus erythematosus (SLE) cases, with more than 100 pharmaceutical agents implicated in its development. Depending on the offending drug, clinical and serological manifestations present great variability and, thus, DILE may be overlooked in clinical practice. Valproic acid (VPA) - induced lupus erythematosus has not been analytically reported in the literature, rendering the recognition of such cases even more difficult. Read More

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A systematic review on mucocutaneous presentations after COVID-19 vaccination and expert recommendations about vaccination of important immune-mediated dermatologic disorders.

Dermatol Ther 2022 Mar 22:e15461. Epub 2022 Mar 22.

Department of Dermatology, Rasool Akram Medical Complex Clinical Research Development Center (RCRDC), School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

With dermatologic side effects being fairly prevalent following vaccination against COVID-19, and the multitude of studies aiming to report and analyze these adverse events, the need for an extensive investigation on previous studies seemed urgent, in order to provide a thorough body of information about these post-COVID-19 immunization mucocutaneous reactions. To achieve this goal, a comprehensive electronic search was performed through the international databases including Medline (PubMed), Scopus, Cochrane, Web of science, and Google scholar on July 12, 2021, and all articles regarding mucocutaneous manifestations and considerations after COVID-19 vaccine administration were retrieved using the following keywords: COVID-19 vaccine, dermatology considerations and mucocutaneous manifestations. A total of 917 records were retrieved and a final number of 180 articles were included in data extraction. Read More

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[COVID-19 induced Stevens-Johnson syndrome].

Ugeskr Laeger 2022 03;184(10)

Afdeling for Hud- og Kønssygdomme, Aalborg Universitetshospital.

The past two years have been dominated by COVID-19, the treatment of this virus, vaccination, and complications due to infection. Not all effects of the virus have yet been described. We present a case report in which the patient suffered from Stevens-Johnson syndrome caused by COVID-19. Read More

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Acute ophthalmic manifestations in Mycoplasma induced rash and mucositis.

Ocul Surf 2022 Apr 15;24:145-147. Epub 2022 Mar 15.

Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA; Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

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Unrecognized indication for aortic valve neocuspidization: Patient with warfarin-induced Stevens-Johnson syndrome and toxic epidermal necrolysis.

J Card Surg 2022 Jun 14;37(6):1733-1735. Epub 2022 Mar 14.

Department of Cardiovascular Surgery, Gülhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey.

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe disorders, characterized by necrosis and epidermal detachment. Most important known acquired etiological factor is medications. Warfarin is one of the most common medications of cardiac valve surgery, which may rarely cause SJS or TEN. Read More

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Erythema Multiforme Associated With Phenytoin and Cranial RadiationTherapy (EMPACT) Syndrome Associated With Cranial Radiotherapy and Levetiracetam: A Case Report.

Cureus 2022 Feb 7;14(2):e21989. Epub 2022 Feb 7.

Department of Dermatology, Meram Medical Faculty, Necmettin Erbakan University, Konya, TUR.

Cranial radiotherapy (RT) is an irradiated way to treat patients with brain malignancies. Seizure is the most common symptom. Due to the frequency of seizure risk, cranial RT is usually received concomitant with previously initiated antiepileptic drugs (AED). Read More

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February 2022

Systemic interventions for treatment of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome.

Cochrane Database Syst Rev 2022 03 11;3:CD013130. Epub 2022 Mar 11.

Ottawa Hospital Research Institute, The Ottawa Hospital - General Campus, Ottawa, Canada.

Background: Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome are rare, severe cutaneous adverse reactions usually triggered by medications. In addition to tertiary-level supportive care, various systemic therapies have been used including glucocorticoids, intravenous immunoglobulins (IVIGs), cyclosporin, N-acetylcysteine, thalidomide, infliximab, etanercept, and plasmapheresis. There is an unmet need to understand the efficacy of these interventions. Read More

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Erythema multiforme in COVID-19 patients and following COVID-19 vaccination: manifestations, associations and outcomes.

J Eur Acad Dermatol Venereol 2022 Mar 11. Epub 2022 Mar 11.

Department of Dermatology, Wayne State University, Detroit, MI, USA.

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Dermatological Manifestations of COVID-19 in Children.

Indian Pediatr 2022 05 10;59(5):393-399. Epub 2022 Mar 10.

Department of Dermatology, Amaltas Institute of Medical Sciences, Dewas, Madhya Pradesh.

Context: The clinical picture of pediatric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection differs from adults as do the cutaneous manifestations. In this review, we summarize the varied morphological manifestations of SARS-CoV-2 infection in the pediatric population.

Evidence Acquisition: A comprehensive literature search was conducted (23 September, 2021) across multiple databases (PubMed, EMBASE, MEDLINE and Cochrane) with the relevant keywords. Read More

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Rare paediatric cardiopulmonary presentation of Behcet's disease.

BMJ Case Rep 2022 Mar 9;15(3). Epub 2022 Mar 9.

Paediatrics, Darent Valley Hospital, Dartford, UK.

This case discusses a 10-year-old boy who presented in significant respiratory distress with cardiac tamponade with associated gross ascites and hepatomegaly, requiring urgent transfer for pericardiocentesis. On further investigation, he was found to have multiple pulmonary emboli and evidence of panserositis. An underlying rheumatological cause was suspected in the absence of any evidence of infection or malignancy, and blood tests were positive for anti-double stranded DNA, anticardiolipin and antiglycoprotein antibodies as well as HLA B51. Read More

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