8,622 results match your criteria Erythema Multiforme

Herpes-Associated Erythema Multiforme.

N Engl J Med 2021 05;384(19):1848

Hospital Universitario 12 de Octubre, Madrid, Spain

View Article and Full-Text PDF

A new syndrome of moyamoya disease, kidney dysplasia, aminotransferase elevation, and skin disease associated with de novo variants in RNF213.

Am J Med Genet A 2021 May 7. Epub 2021 May 7.

Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

Ring-finger protein 213 (RNF213) encodes a protein of unknown function believed to play a role in cellular metabolism and angiogenesis. Gene variants are associated with susceptibility to moyamoya disease. Here, we describe two children with moyamoya disease who also demonstrated kidney disease, elevated aminotransferases, and recurrent skin lesions found by exome sequencing to have de novo missense variants in RNF213. Read More

View Article and Full-Text PDF

Erythema multiforme after treatment with sorafenib.

Proc (Bayl Univ Med Cent) 2021 Mar 8;34(3):380-381. Epub 2021 Mar 8.

Department of Dermatology, Baylor Scott & White Medical Center - Temple, Temple, Texas.

Sorafenib, an oral chemotherapeutic agent used in the treatment of solid tumors, is associated with a variety of adverse cutaneous drug reactions in up to 90% of patients. Infrequently, delayed-type hypersensitivity reactions such as erythema multiforme occur. This case describes a child treated with sorafenib for a retrosternal desmoid tumor who developed widespread erythema multiforme across his extremities, trunk, face, and mucosal membranes. Read More

View Article and Full-Text PDF

Role of CD123 (+) Plasmacytoid Dendritic Cells in Etiologically Different Variants of Erythema Multiforme: A Monocentric Retrospective Study.

Dermatopathology (Basel) 2021 Apr 3;8(2):89-96. Epub 2021 Apr 3.

Department of Pathology and Laboratory Medicine, University of Rochester Medical Center (URMC), Rochester, NY 14642, USA.

Plasmacytoid dendritic cells (pDCs) constitute a subset of dendritic cells known to be the "professional" interferon type I (IFN-I) producers. pDCs play an important role in antiviral immunity, as well as linking innate and adaptive immunity. Under normal conditions pDCs are not present in skin. Read More

View Article and Full-Text PDF

A flare of pre-existing erythema multiforme post BNT162b2 (Pfizer-BioNTech) COVID-19 vaccine.

Clin Exp Dermatol 2021 Apr 29. Epub 2021 Apr 29.

Department of Dermatology, Liverpool University Hospitals NHS Foundation Trust, Liverpool, United Kingdom.

The coronavirus disease (COVID)-19 pandemic has resulted in significant morbidity and mortality worldwide. The emergency use authorisation of COVID-19 vaccinations in December 2020 has led to renewed optimism of reducing the prevalence and burden on healthcare systems. Three vaccinations have now been granted temporary authorisation in the United Kingdom: BNT162b2, ChAdOx1 and mRNA-1273. Read More

View Article and Full-Text PDF

Pityriasis rubra pilaris post-infection due COVID-19: case report.

Colomb Med (Cali) 2021 Mar 18;52(1):e7014577. Epub 2021 Mar 18.

Universidad San Ignacio de Loyola, Lima, Perú. Universidad San Ignacio de Loyola Universidad San Ignacio de Loyola Lima Peru.

Case Description: 32-month-old boy, IgG positive for SARS-CoV-2, presented to the emergency department with dermatologic lesions.

Clinical Findings: Four days before admission, he presented skin eruptions with redness and pruritus on hands and feet. Generalized papular erythema was evidenced, upper extremities with diffuse erythematosquamous plaques, palmoplantar keratoderma, so he was evaluated by a dermatologist who diagnosed pityriasis rubra pilaris. Read More

View Article and Full-Text PDF

Drug induced oral erythema multiforme: Case report.

Medicine (Baltimore) 2021 Apr;100(17):e22387

Assistant Professor, Department of Prosthetic Dentistry, College of Dentistry, King Khalid University, Abha, Kingdom of Saudi Arabia.

Introduction: Drug induced oral erythema multiforme a rare clinical entity which involves only the lips and oral mucosa without skin involvement. These lesions are difficult in diagnosing with other oral ulcerative lesions with similar clinical manifestations.

Patient Concerns: This article presents 2 case reports of Oral erythema multiforme in which drugs were the precipitating factor. Read More

View Article and Full-Text PDF

Cutaneous Manifestations of COVID-19.

Cutis 2021 Feb;107(2):90-94

Ms. Schwartzberg is from the New York Institute of Technology College of Osteopathic Medicine, Old Westbury. Dr. Lin is from the Department of Dermatology, St. John's Episcopal Hospital, Far Rockaway, New York. Dr. Jorizzo is from the Department of Dermatology, Wake Forest Baptist Health, Winston-Salem, North Carolina, and Weill Cornell Medicine Dermatology, New York, New York.

Patients with coronavirus disease 2019 (COVID-19) present with multisystem signs and symptoms, including dermatologic manifestations. The recent literature has revealed that dermatologic manifestations of COVID-19 often are early onset and provide helpful cues to a timely diagnosis. We compiled the relevant emerging literature regarding the dermatologic manifestations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) so that physicians can be aware of the various clinical cutaneous presentations in this time of high incidence of COVID-19. Read More

View Article and Full-Text PDF
February 2021

Cutaneous manifestations associated with anosmia, ageusia and enteritis in SARS-CoV-2 infection - A possible pattern? Observational study and review of the literature.

Int J Infect Dis 2021 Apr 19;107:72-77. Epub 2021 Apr 19.

Faculty of Medicine, Lucian Blaga University of Sibiu, Sibiu, Romania; Dermatology Clinic, Academic Emergency Hospital Sibiu, Sibiu, Romania.

Background: The cutaneous manifestations of coronavirus disease 2019 (COVID-19) have been covered insufficiently in the literature.

Methods: Thirty-nine patients admitted to the study hospital with confirmed COVID-19 who experienced various skin manifestations during hospitalization or in the convalescence period, were analysed retrospectively.

Results: Thirty-nine patients with COVID-19, admitted to the study hospital between 23 March and 12 September 2020, had intra-infectious rash or lesions of cutaneous vasculitis during convalescence. Read More

View Article and Full-Text PDF

Simultaneous Development of Gianotti-Crosti Syndrome and Erythema Multiforme Following Second Dose of Measles-rubella Vaccine.

Masahiro Oka

Acta Derm Venereol 2021 Apr 26;101(4):adv00438. Epub 2021 Apr 26.

Department of Dermatology, Kita-Harima Medical Center, 675-1392 Ono, Japan. E-mail:

View Article and Full-Text PDF

Mycoplasma pneumoniae-induced rash and mucositis: A new entity.

Indian J Dermatol Venereol Leprol 2021 Mar 12:1-5. Epub 2021 Mar 12.

Department Dermatology Fattouma Bourguiba University Hospital, University of Medicine, University of Monastir, Monastir, Tunisia.

Mycoplasma pneumoniae is a well-known cause of community-acquired pneumonia, mostly associated with dermatological manifestations especially with mucosal involvement and targetoid cutaneous lesions. For many years, it was considered among the spectrum of erythema multiforme. Recently, some authors have recommended the creation of a new syndrome called "mycoplasma-induced rash and mucositis. Read More

View Article and Full-Text PDF

Severe Acute Respiratory Syndrome Coronavirus 2 Vaccines and Cutaneous Adverse Reactions: A Review.

Dermatitis 2021 Apr 13. Epub 2021 Apr 13.

From the Dermatology Department, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte EPE Dermatology Universitary Clinic, Faculty of Medicine Dermatology Research Unit, iMM João Lobo Antunes, University of Lisbon Dermatology Department, Hospital CUF Descobertas, Lisbon, Portugal.

We are entering a new stage of the severe acute respiratory syndrome coronavirus 2 pandemic with the initiation of large-scale vaccination programs globally. In these circumstances, even rare adverse effects of vaccines may be encountered more often, if millions of people are to be vaccinated in a short period. Vaccination has the potential for causing cutaneous adverse effects. Read More

View Article and Full-Text PDF

[Lupus erythematosus associated with erythema multiforme or Rowell's syndrome. Report of one case].

Rev Med Chil 2020 Nov;148(11):1690-1693

Departamento de Anatomía Patológica, Facultad de Medicina, Universidad de Chile, Santiago, Chile.

Rowell's syndrome is characterized by an association of lupus erythematosus and erythema multiforme, with distinctive laboratory findings. Its treatment is similar to lupus. We report a 16-year-old female presenting with skin lesions, laboratory and histology consistent with this entity. Read More

View Article and Full-Text PDF
November 2020

Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: A registry-based study of 414 cases.

J Am Acad Dermatol 2021 Apr 7. Epub 2021 Apr 7.

Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Medical Practice Evaluation Center, Mongan Institute, Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

Background: Cutaneous reactions after messenger RNA (mRNA)-based COVID-19 vaccines have been reported but are not well characterized.

Objective: To evaluate the morphology and timing of cutaneous reactions after mRNA COVID-19 vaccines.

Methods: A provider-facing registry-based study collected cases of cutaneous manifestations after COVID-19 vaccination. Read More

View Article and Full-Text PDF

Neuropsychiatric manifestations in an adolescent male with Rowell syndrome.

J Postgrad Med 2021 Apr-Jun;67(2):109-112

Department of Pathology, Yenepoya Medical College, Yenepoya (Deemed to be University), Mangalore, Karnataka, India.

A 15-year-old boy presented with fever, skin, and oral lesions for 4 weeks. The cutaneous lesions were suggestive of subacute cutaneous lupus erythematosus and erythema multiforme. His clinical, histopathological, and immunological features were indicative of Rowell syndrome and he satisfied the diagnostic criteria of Rowell syndrome proposed by Zeitouni et al. Read More

View Article and Full-Text PDF

Phase I study of tamibarotene monotherapy in pediatric and young adult patients with recurrent/refractory solid tumors.

Cancer Chemother Pharmacol 2021 Apr 7. Epub 2021 Apr 7.

Clinical Research Support Office, National Cancer Center Hospital East, Chiba, Japan.

Purpose: Tamibarotene is a synthetic retinoid that inhibits proliferation and induces differentiation of malignant cells by binding to the retinoic acid receptor α/β. Previous in vitro studies have shown that some pediatric solid tumors with retinoic acid receptors differentiate in response to retinoic acid. We conducted a phase I dose-escalation study to determine the recommended dose of tamibarotene for further study in pediatric and young adult patients with recurrent/refractory solid tumors. Read More

View Article and Full-Text PDF

Targetoid lesions in a patient with systemic lupus erythematosus.

Dermatol Online J 2021 Feb 15;27(2). Epub 2021 Feb 15.

Department of Dermatology, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, USA, Regional Medical Laboratory, Tulsa, OK.

Rowell Syndrome is a rare presentation of lupus erythematosus manifesting as an eruption of erythema multiforme-like papules and plaques with immunological findings of positive rheumatoid factor, speckled antinuclear antibodies, and/or anti-Ro/La antibodies. This case highlights the unusual and highly debated presentation of Rowell Syndrome in a 66-year-old woman with newly-appearing erythematous, targetoid plaques in the setting of previously diagnosed systemic lupus erythematosus. Skin biopsy revealed histological features of full-thickness epidermal necrosis with focal sub-epidermal separation and a superficial perivascular lymphocytic infiltrate interpreted to favor Rowell Syndrome given her clinical history and presentation. Read More

View Article and Full-Text PDF
February 2021

Time of Onset of Selected Skin Lesions Associated with COVID-19: A Systematic Review.

Dermatol Ther (Heidelb) 2021 Apr 2. Epub 2021 Apr 2.

Division of Dermatology, San Bortolo Hospital, Vicenza, Italy.

Introduction: Distinct skin lesions associated with coronavirus disease 2019 (COVID-19) have been described, but data regarding their time of onset during the COVID-19 course are scant. Our objective was to systematically review the studies reporting the time of onset of selected skin lesions with respect to the reported onset of the COVID-19 core symptoms.

Methods: A comprehensive search of studies published before 21 January 2021 was performed on MEDLINE via PubMed database using a predefined strategy to identify relevant articles. Read More

View Article and Full-Text PDF

Mucosal Respiratory Syndrome: A Systematic Literature Review.

Dermatology 2021 Mar 26:1-7. Epub 2021 Mar 26.

Pediatric Institute of Southern Switzerland, Ospedale San Giovanni, Bellinzona, Switzerland.

Background: Mycoplasma pneumoniae atypical pneumonia is frequently associated with erythema multiforme. Occasionally, a mycoplasma infection does not trigger any cutaneous but exclusively mucosal lesions. The term mucosal respiratory syndrome is employed to denote the latter condition. Read More

View Article and Full-Text PDF

Bee propolis-induced erythema multiforme.

J Formos Med Assoc 2021 Mar 20. Epub 2021 Mar 20.

Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Dentistry, Far Eastern Memorial Hospital, New Taipei City, Taiwan; Department of Dentistry, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan. Electronic address:

View Article and Full-Text PDF

Case Report: Enfortumab Vedotin for Metastatic Urothelial Carcinoma: A Case Series on the Clinical and Histopathologic Spectrum of Adverse Cutaneous Reactions From Fatal Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis to Dermal Hypersensitivity Reaction.

Front Oncol 2021 4;11:621591. Epub 2021 Mar 4.

Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.

Enfortumab vedotin is a Nectin-4 directed antibody-drug conjugate approved in metastatic urothelial carcinoma following progression on a platinum-containing chemotherapy and immune checkpoint blockade. On-target dermatologic toxicity may occur from Nectin-4 expression in the skin. We highlight a case of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis following enfortumab infusions that was ultimately fatal. Read More

View Article and Full-Text PDF

Steroid-refractory dermatologic and pulmonary toxicity in a patient on rituximab treated with pembrolizumab for progressive urothelial carcinoma: a case report.

J Med Case Rep 2021 Mar 19;15(1):124. Epub 2021 Mar 19.

Section of Rheumatology, Department of Medicine, UChicago Medicine, Chicago, IL, USA.

Background: Increasingly widespread use of programmed cell death protein 1 (PD-1) immune checkpoint inhibitors (ICIs) for treatment of a variety of progressive malignancies continues to reveal a range of immune-related adverse events (irAEs), necessitating immunosuppressive therapy for management. While a single course of systemic corticosteroids may be sufficient for many irAEs, no clear standard-of-care guidelines exist for steroid-refractory cases. We present an unusual case of a patient who developed several steroid-refractory novel irAEs on pembrolizumab despite ongoing B cell-directed immunosuppressive therapy with rituximab, who ultimately noted resolution of symptoms with tacrolimus, a T-cell-directed immunosuppressant. Read More

View Article and Full-Text PDF

Blistering severe cutaneous adverse reactions in children: Proposal for pediatric-focused clinical criteria.

Br J Dermatol 2021 Mar 17. Epub 2021 Mar 17.

Division of Pediatric and Adolescent Dermatology, Rady Children's Hospital, San Diego, California, USA.

Severe cutaneous adverse reactions (SCARs) are challenging to diagnose and manage in children for two main reasons: 1) The literature on SCARs in children is sparse and extrapolated from adult data, 2) Many paediatric blistering SCAR cases are qualified as 'atypical' or 'incomplete' erythema multiforme (EM), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) because certain clinical features make them not fit into this adult classification. Our panel proposes paediatric-focused clinical criteria for blistering SCARs in children to improve early diagnosis and facilitate acute management. Read More

View Article and Full-Text PDF

Ciprofloxacin-induced cutaneous adverse drug events: a systematic review of descriptive studies.

J Basic Clin Physiol Pharmacol 2021 Mar 16. Epub 2021 Mar 16.

Department of Pharmacy Practice, Indo Soviet Friendship College of Pharmacy, Moga, Punjab, India.

Objectives: Ciprofloxacin (CIPRO) is a fluroquinolone class antibiotic used commonly for the treatment of various acute and chronic bacterial infections. However, recently there is increase in the case reports of CIPRO-induced Cutaneous Adverse Drug Reactions (CADRs). We aim to systematically review all the descriptive studies of CIPRO induced CADRs. Read More

View Article and Full-Text PDF

[Ocular involvement in Stevens-Johnson syndrome and toxic epidermal necrolysis].

Ophthalmologe 2021 May 16;118(5):519-532. Epub 2021 Mar 16.

Klinik und Poliklinik für Augenheilkunde, Campus Virchow-Klinikum, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin und Berlin Institute of Health, Augustenburger Platz 1, 13353, Berlin, Deutschland.

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare severe and often life-threatening reactions of the skin and mucous membranes. They are considered as a single disease entity with different expressions of severity and are summarized under the term epidermal necrolysis (EN). There is a high risk of ocular involvement, which can lead to long-lasting eye problems and even blindness without immediate ophthalmological treatment. Read More

View Article and Full-Text PDF


Mikiko Tohyama

Arerugi 2021;70(2):80-85

Department of Dermatology, National Hospital Organization Shikoku Cancer Center.

View Article and Full-Text PDF
January 2021

Cutaneous toxicities occurring during palbociclib (CDK4/6 inhibitor) and endocrine therapy in patients with advanced breast cancer: a single-centre experience.

Breast Cancer Res Treat 2021 Mar 8. Epub 2021 Mar 8.

Dermatology Department, Skin Unit, The Royal Marsden NHS Foundation Trust, Fulham Road, London, SW3 6JJ, UK.

Purpose: Treatment with Palbociclib, a cyclin-dependent kinase 4/6 inhibitor, has demonstrated significantly improved progression-free survival in patients with hormone receptor-positive, HER2-negative, advanced breast cancer, when used in combination with letrozole or fulvestrant endocrine therapies. However, limited information exists on its cutaneous adverse effects (AE). Hence, we conducted a retrospective cohort study to investigate the prevalence and management of cutaneous AE during palbociclib and endocrine therapy. Read More

View Article and Full-Text PDF

The Clinical and Histopathological Features of Cutaneous Immune-Related Adverse Events and Their Outcomes.

J Clin Med 2021 Feb 12;10(4). Epub 2021 Feb 12.

Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.

Immune checkpoint inhibitors (ICIs) cause a variety of inflammatory eruptions. The understanding of ICI-induced inflammatory eruptions with detailed histopathological findings is not adequate, particularly in Asian populations. In this study, we retrospectively reviewed 51 patients who were histopathologically diagnosed with cutaneous immune-related adverse events (irAEs) following ICI therapy between 2014 and 2020 at the Department of Dermatology of Kyushu University Hospital. Read More

View Article and Full-Text PDF
February 2021

A Case of Bullous Rash Apparently Triggered by Meningococcal and Rotavirus Vaccines in an Infant: Focus on Infantile Bullous Pemphigoid.

Dermatopathology (Basel) 2021 Feb 23;8(1):33-36. Epub 2021 Feb 23.

Dermatology-IRCCS Policlinico di Sant'Orsola-Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Alma Mater Studiorum-University of Bologna, 40138 Bologna, Italy.

Bullous pemphigoid (BP) is an autoimmune bullous disease and is a rare condition in childhood. Acquired tense acral bullae and fixed urticarial annular lesions on the trunk are diagnostic clues of infantile BP. Diagnosis is supported by immunosorbent assay (IgG anti-BP180 and BP230) and direct immunofluorescence (linear deposition of IgG at the dermo-epidermal junction). Read More

View Article and Full-Text PDF
February 2021