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    7790 results match your criteria Erythema Multiforme

    1 OF 156

    Desquamative gingivitis: Clinical findings and diseases.
    J Am Acad Dermatol 2018 May;78(5):839-848
    Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, North Carolina; Department of Dermatology, Weill Cornell Medical College, New York, New York.
    Desquamative gingivitis is a clinical finding with several potential etiologies. Among the most common are oral lichen planus, cicatricial pemphigoid, and pemphigus vulgaris, though various other differential diagnoses exist. The presence of desquamative gingivitis often results in poor oral hygiene, which can have downstream consequences, including periodontitis and tooth loss. Read More

    [Urticaria multiforme: difficult to distinguish from other skin conditions].
    Ned Tijdschr Geneeskd 2018 ;162(0):D2251
    Westfriesgasthuis, afd. Kindergeneeskunde en Neonatologie, Hoorn.
    Background: Urticaria multiforme is a rare clinical variant of urticaria that occurs specifically in children.

    Case Description: A boy aged 11 months was presented at the Emergency Department with acute onset of itching urticarial skin weals and acral oedema. This picture is consistent with the diagnosis of urticaria multiforme. Read More

    RS3PE syndrome developing during the course of probable toxic shock syndrome: a case report.
    BMC Infect Dis 2018 Apr 13;18(1):174. Epub 2018 Apr 13.
    Department of Internal Medicine, Hyogo Prefectural Kaibara Hospital, 5208-1, Kaibara, Kaibara-cho, Tanba, Hyogo, 669-3395, Japan.
    Background: Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) is a rare syndrome characterized by "remitting," "seronegative" (namely rheumatoid factor-negative), and "symmetrical" synovitis with pitting edema on the dorsum of the hands and feet. Recently, there have been reports that serum vascular endothelial growth factor (VEGF) is elevated in this condition.

    Case Presentation: An 85-year-old man visited our department with a rash that had appeared 2 days earlier and a fever that had developed on the day of his visit. Read More

    From HSV infection to erythema multiforme through autoimmune crossreactivity.
    Autoimmun Rev 2018 Apr 7. Epub 2018 Apr 7.
    Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania 'Luigi Vanvitelli', Via de Crecchio 6, 80138 Naples, Italy. Electronic address:
    Scientific and clinical data indicate that human herpes simplex virus 1 (HSV1) and, at a lesser extent, human herpes simplex virus 2 (HSV2) are factor(s) implicated in the development of erythema multiforme (EM). With a focus on oral EM, the present structured review of proteomic and epitope databases searched for the molecular basis that might link HSV1 and HSV2 infections to EM. It was found that a high number of peptides are shared between the two HSVs and human proteins related to the oral mucosa. Read More

    Association of HLA-A*31:01 Screening With the Incidence of Carbamazepine-Induced Cutaneous Adverse Reactions in a Japanese Population.
    JAMA Neurol 2018 Apr 2. Epub 2018 Apr 2.
    RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
    Importance: Carbamazepine, a commonly used antiepileptic drug, is one of the most common causes of cutaneous adverse drug reactions (cADRs) worldwide. The allele HLA-A*31:01 is reportedly associated with carbamazepine-induced cADRs in Japanese and European populations; however, the clinical utility of HLA-A*31:01 has not been evaluated.

    Objective: To assess the use of HLA-A*31:01 genetic screening to identify Japanese individuals at risk of carbamazepine-induced cADRs. Read More

    Histopathology of Cutaneous Inflammatory Disorders in Children.
    Pediatr Dev Pathol 2018 Mar-Apr;21(2):115-149
    1 Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri.
    Inflammatory dermatoses encompass a variety of histologic patterns that affect different portions of the skin. In spongiotic, psoriasiform, lichenoid, pityriasiform, and blistering disorders, there are predominately epidermal and junctional activities with variable superficial dermal inflammation. Hypersensitivity reactions can show either epidermal or mostly dermal changes depending on whether the exposure of the exogenous allergen occurs through an external or internal route, respectively. Read More

    Selected presentations of lip enlargement: clinical manifestation and differentiation.
    Postepy Dermatol Alergol 2018 Feb 20;35(1):18-25. Epub 2018 Feb 20.
    Department of Oral Surgery, Poznan University of Medical Sciences, Poznan, Poland.
    Lip enlargement may be an important symptom of either systemic or local diseases. On the basis of selected age-matched clinical cases we present the possible causes of lip swelling. We describe the most representative symptoms and recommend treatment of these pathologies. Read More

    Tularemia-induced erythema multiforme minor in an 11-year-old girl.
    Pediatr Dermatol 2018 Mar 26. Epub 2018 Mar 26.
    Department of Dermatology, University of California, San Francisco, CA, USA.
    Tularemia is a rare and potentially life-threatening infection caused by the highly infectious gram-negative coccobacillus Francisella tularensis. We present the case of an 11-year old girl who presented with erythema multiforme minor in the setting of an indolent but progressive soft tissue infection and was found to have tularemia. We review the role of dermatologists in identifying the features of and complications associated with this rare zoonosis and discuss the potential effect of climate change on its incidence. Read More

    Mycoplasma pneumoniae-related erythema multiforme: clinical and histological features. A single center series of 33 cases compared to 100 cases induced by other causes.
    J Am Acad Dermatol 2018 Mar 17. Epub 2018 Mar 17.
    Dermatology department, AP-HP, Henri Mondor hospital, Créteil; EA 7379 EpiDermE (Epidémiologie en Dermatologie et Evaluation des Thérapeutiques), Université Paris-Est Créteil Val de Marne (UPEC), Creteil; Referral center for toxic bullous diseases, AP-HP, Henri Mondor hospital, Créteil; Université Paris Est-Créteil UPEC, Créteil.
    Background: Mycoplasma pneumoniae (MP) infection has been documented in erythema multiforme (EM) and Stevens-Johnson syndrome-toxic epidermal necrosis (SJS-TEN). Clinical aspects of MP-related EM (MP-EM) have been poorly described in the literature.

    Objective: To highlight differences between MP-EM and non-MP-EM. Read More

    Smallpox vaccine complications: the dermatologist's role in diagnosis and management.
    Cutis 2018 Feb;101(2):87-90
    University of Colorado Hospital, Aurora, USA.
    In 2002, the United States implemented a new program for smallpox vaccinations among military personnel using a live vaccinia virus product. Approximately 2.4 million US military service members and health care workers have since been inoculated, with considerable numbers experiencing adverse reactions. Read More

    Reactive perforating leprosy, erythema multiforme-like reactions, sweet's syndrome-like reactions as atypical clinical manifestations of Type 2 leprosy reaction.
    Int J Mycobacteriol 2018 Jan-Mar;7(1):97-100
    Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran, Dr. Hasan Sadikin General Hospital, Bandung, Indonesia.
    Type 2 leprosy reactions commonly known as erythema nodosum leprosum, but various clinical manifestations of type 2 leprosy reaction were exist. The highlight of this case series was to report various atypical clinical manifestations of type 2 leprosy reaction such as reactive perforating leprosy, erythema multiforme-like reaction, and sweet's syndrome (SS)-like reaction. Read More

    A Case of Erythema Multiforme Major Developed after Sequential Use of Two Immune Checkpoint Inhibitors, Nivolumab and Ipilimumab, for Advanced Melanoma: Possible Implication of Synergistic and/or Complementary Immunomodulatory Effects.
    Case Rep Dermatol 2018 Jan-Apr;10(1):1-6. Epub 2018 Jan 18.
    Department of Dermatology, Division of Medical Sciences, University of Fukui, Fukui, Japan.
    Immune checkpoint inhibitors, such as ipilimumab and nivolumab, reverse the imbalance of antitumor self-tolerance and enhance T-cell responses. Currently, ipilimumab and nivolumab have a reported therapeutic impact on unresectable or metastatic melanomas; however, they also induce immune-related adverse events (irAEs). Ipilimumab-induced cutaneous irAEs are mostly low grade and manageable, although all-grade rash may occur in approximately 45% of all patients. Read More

    Nursing care of a boy seriously infected with Steven-Johnson syndrome after treatment with azithromycin: A case report and literature review.
    Medicine (Baltimore) 2018 Jan;97(1):e9112
    Department of Children's Critical Care Medicine, Xin-Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
    Rationale: Stevens-Johnson syndrome (SJS) is an acute blistering disease of the skin and mucous membranes. SJS in children is not common but potentially serious disease. But the epidemiology of SJS in China is not well defined. Read More

    Segmental Erythema Multiforme-Like Drug Eruption by Aromatase Inhibitor Anastrozole - First Case Report and another Example of an Immunocompromised District.
    Open Access Maced J Med Sci 2018 Jan 3;6(1):79-81. Epub 2018 Jan 3.
    Università Degli Studi "G. Marconi", Rome, Italy.
    Anastrozole is a non-selective aromatase inhibitor for adjuvant breast cancer therapy in postmenopausal women. Cutaneous adverse events have been reported. We observed a 64-year-old female patient with a medical history of locally advanced breast cancer of her right breast that was treated with radiotherapy and adjuvant drug therapy with anastrozole. Read More

    [A Case of Metastatic Colorectal Cancer with Brain Metastasis Treated with Combined TFTD and Bevacizumab Therapy].
    Gan To Kagaku Ryoho 2018 Feb;45(2):318-320
    Dept. of Surgical Oncology, Gifu University.
    A woman in her 70s was confirmed as presenting with multiple liver and lung metastases from transverse colon cancer. After undergoing resection of the primary lesion, partial response(PR)was achieved after undergoing the first regimen (sLV5FU2 and bevacizumab[Bmab]); therefore, partial hepatectomy was performed. Adjuvant chemotherapy was administered for 7 months, but liver metastasis recurrence, multiple lung metastases, and brain metastasis were confirmed. Read More

    A case of erythema multiforme major following administration of ciprofloxacin ophthalmic drops.
    Dermatol Online J 2017 Oct 15;23(10). Epub 2017 Oct 15.
    University of Texas Medical Branch at Galveston Department of Dermatology Galveston, Texas.
    A 49-year old woman was hospitalized for generalized rash and pruritus following the administration of ophthalmic drops containing ciprofloxacin to treat conjunctivitis. Physical examination demonstrated diffuse erythematous papules and plaques with a targetoid appearance, injected sclera, and multiple erosions in the oropharynx. Skin biopsy confirmed a diagnosis of erythema multiforme major. Read More

    Vaccine-induced toxic epidermal necrolysis: A case and systematic review.
    Dermatol Online J 2018 Jan 15;24(1). Epub 2018 Jan 15.
    Division of Dermatology, University of California Los Angeles, Los Angeles, California.
    Background: Erythema multiforme (EM), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are cutaneous hypersensitivityreactions that develop in response to specific triggers such as medications and certain infections. Vaccines, which undergo rigorous safety testing prior to use in humans, are a rare cause of SJS/TEN and little is known about the frequency of such events and corresponding pathogenesis.

    Objective: Herein, we discuss a case of suspected TEN in a 19-year-old woman who received the meningococcal B vaccine (the first report of such an association) and conduct a systematic review of the associated literature. Read More

    Erythema multiforme major in a patient with metastatic melanoma treated with nivolumab.
    Dermatol Online J 2017 Sep 15;23(9). Epub 2017 Sep 15.
    The University of Texas Health Science Center at Houston - UT Health, Department of Dermatology, Houston, Texas,.
    Nivolumab, a relatively novel immune checkpoint inhibitor with FDA approval in 2014, is gaining greater utilization due to its efficacy in treating metastatic melanoma. Many of the cutaneous immune-related adverse events (irAEs) being catalogued do not necessitate discontinuation of immunotherapy and are managed with supportive therapy. We present a case of erythema multiforme major secondary to nivolumab requiring hospitalization and discontinuation of treatment. Read More

    Pediatric Lip Adhesion Following Bullous Erythema Multiforme and Review of Similar Oral Complications.
    J Cutan Med Surg 2018 Feb 1:1203475418761038. Epub 2018 Feb 1.
    3 Division of Paediatric Medicine, Section of Dermatology, Hospital for Sick Children, Toronto, ON, Canada.
    Background: Erythema multiforme (EM) is a mucocutaneous disease most often associated with preceding herpes simplex virus or Mycoplasma pneumoniae infection. It is characterized by targetoid lesions occurring on the limbs and head and neck. Mucosal involvement can be extensive. Read More

    A 65-Year-Old Male with Primary Central Nervous System Diffuse Large B-Cell Lymphoma on Nivolumab with Oral Mucositis and Targetoid Plaques.
    Dermatopathology (Basel) 2017 Jan-Dec;4(1-4):13-17. Epub 2017 Nov 16.
    Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
    Background/aims: The development of programmed cell death-1 (PD-1) inhibitors has greatly improved patient outcomes in the treatment of a variety of advanced malignancies. These novel immunotherapies are not without adverse effects, the most common of which are dermatologic.

    Methods: We report our experience with an atypical erythema multiforme-like eruption in a patient with primary central nervous system diffuse large B-cell lymphoma treated with nivolumab. Read More

    Drug-induced Rowell syndrome, a rare and difficult to manage disease: A case report.
    Exp Ther Med 2018 Jan 23;15(1):785-788. Epub 2017 Nov 23.
    Department of Ophthalmology, Grigore T. Popa University of Medicine and Pharmacy, 700715 Iași, Romania.
    Rowell syndrome is defined as the association between lupus erythematosus, erythema multiforme-like lesions and characteristic immunological changes including positive tests for rheumatoid factor, speckled antinuclear antibody, positive anti-Ro or anti-La antibodies. The present report presents the case of a 45-year-old female patient who was previously diagnosed in January 2010 with terbinafine-induced subacute cutaneous lupus erythematosus and was admitted for a skin eruption consisting of erythematous-papular erythema multiforme-like lesions, primarily on the trunk and limbs. The associated symptoms consisted of fatigability, myalgia and gonalgia. Read More

    A secondary syphilis rash with scaly target lesions.
    Oxf Med Case Reports 2018 Feb 1;2018(2):omx089. Epub 2018 Feb 1.
    Microbiologie Médicale et Infectiologie, Centre Hospitalier de l'Université de Montréal, Montréal, Canada.
    A 40-year-old man reported a 5-day history of fever and malaise, followed by a pruritic generalized rash. He had well-demarcated erythematous papules and plaques with scaling. The patient was diagnosed with secondary syphilis. Read More

    Successful drug desensitization in patients with delayed-type allergic reactions to anti-tuberculosis drugs.
    Int J Infect Dis 2018 Mar 2;68:61-68. Epub 2018 Feb 2.
    Bamrasnaradura Infectious Diseases Institute, Nonthaburi, Thailand.
    Objective: To evaluate the outcomes of anti-tuberculosis drug desensitization.

    Methods: This was a retrospective study. Inclusion criteria were as follows: age >18years, documented tuberculosis infection, a previous cutaneous allergic reaction to anti-tuberculosis drugs, and having undergone drug desensitization between January 2003 and March 2014. Read More

    [A Case of Small Intestinal GIST with Long-Term Survival after Tumor Resection for Repeated Peritoneal Recurrence].
    Gan To Kagaku Ryoho 2017 Nov;44(12):1521-1522
    Dept. of Surgery, Shiga University of Medical Science.
    A 70-year-old woman presenting with abdominal pain was admitted to our hospital. Abdominal contrast CT revealed a small intestine tumor of 10 cm with active bleeding and performed partial resection of the small intestine including tumor. Pathological findings were high risk GIST of the small intestine because of spindle cells and c-kit positive. Read More

    Stevens-Johnson syndrome/toxic epidermal necrolysis and erythema multiforme drug-related hospitalisations in a national administrative database.
    Clin Transl Allergy 2018 22;8. Epub 2018 Jan 22.
    1Basic and Clinical Immunology, Department of Pathology, Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal.
    Background: Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) and erythema multiforme (EM) are immunologically-mediated dermatological disorders commonly triggered by drug exposure and/or other external agents. We aimed to characterise SJS/TEN- and EM-drug-related hospitalisations in a nationwide administrative database, focusing on demographic and clinical characteristics, and in the most frequently implicated drug classes.

    Methods: We analysed all drug-related hospitalisations with associated diagnosis of SJS/TEN or EM in Portuguese hospitals between 2009 and 2014. Read More

    Drug-induced oral erythema multiforme: A diagnostic challenge.
    Ann Afr Med 2018 Jan-Mar;17(1):43-45
    Department of Oral and Maxillofacial Surgery Sciences, Division of Oral Pathology and Microbiology, Najran University College of Dentistry, Najran, Saudi Arabia.
    Trimethoprim-sulfamethoxazole (cotrimoxazole or TMP/SMX) is commonly used for the treatment of urinary or lower respiratory tract infections. A comprehensive review is presented of the world literature on adverse reactions to TMP/SMX since its first use in 1968, when concern was expressed about possible hematologic toxicity. The adverse reactions to TMP/SMX occur in approximately 1%-3% of persons in general population. Read More

    Current Perspectives on Erythema Multiforme.
    Clin Rev Allergy Immunol 2018 Feb;54(1):177-184
    Unité d'allergologie, Service d'immunologie et d'allergologie, Hôpitaux Universitaires de Genève HUG, Rue Micheli-du-Crest 24, CH-1211, Genève, Switzerland.
    Recognition and timely adequate treatment of erythema multiforme remain a major challenge. In this review, current diagnostic guidelines, potential pitfalls, and modern/novel treatment options are summarized with the aim to help clinicians with diagnostic and therapeutic decision-making. The diagnosis of erythema multiforme, that has an acute, self-limiting course, is based on its typical clinical picture of targetoid erythematous lesions with predominant acral localization as well as histological findings. Read More

    Severe erythema multiforme-type drug eruption controlled by tumor necrosis factor-α antagonist: A case study.
    Exp Ther Med 2017 Dec 18;14(6):5727-5732. Epub 2017 Oct 18.
    Department of Dermatology, Suzhou Municipal Hospital, Suzhou, Jiangsu 215006, P.R. China.
    Using a tumor necrosis factor-α antagonist, the present study successfully treated a case of severe erythema multiform-type drug eruption, which occurred following anti- therapy. A 73-year-old female suffering from upper gastrointestinal bleeding and peptic-ulcer presented with an itchy rash, fever, an increase in leukocytes and eosinophils and lymphadenectasis following oral administration of amoxicillin. Following six subcutaneous injections of etanercept (initially 50 mg, then 25 mg every 3 days), the patient was deemed to have recovered. Read More

    Risperidone-induced Erythema Multiforme Minor.
    Indian J Psychol Med 2017 Nov-Dec;39(6):808-810
    Department of Psychiatry, Government Medical College, Akola, Maharashtra, India.
    Antipsychotic agents are known to cause adverse cutaneous reactions. These are supposedly rare with atypical antipsychotic agents. Adverse dermatologic reactions due to antipsychotic agent risperidone are rarely reported. Read More

    Drug reaction with eosinophilia and systemic symptoms in a child on multiple antiepileptics.
    Turk J Pediatr 2017 ;59(2):197-199
    Departments of Pediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
    Goswami JN, Vaidya PC, Saini AG, De D, Radotra BD, Singhi PD. Drug reaction with eosinophilia and systemic symptoms in a child on multiple antiepileptics. Turk J Pediatr 2017; 59: 197-199. Read More

    Cutaneous Adverse Drug Reactions in a Tertiary Care Teaching Hospital in India: An Intensive Monitoring Study.
    Indian J Dermatol 2017 Nov-Dec;62(6):618-625
    Department of Skin and VD, GMERS Medical College, Gotri, Vadodara, Gujarat, India.
    Background: The epidemiological data based on intensive monitoring studies are limited for the cutaneous adverse drug reactions (CADRs) in terms of incidence. Most of earlier Indian studies focused only on types and causative drugs of CADRs.

    Aim: The aim of this study is to analyze the CADRs with reference to the incidence, its subgroup analysis, causative drugs, and other clinical characteristics in Indian population. Read More

    Bullous Pemphigoid Masquerading as Erythema Annulare Centrifugum.
    Acta Dermatovenerol Croat 2017 Oct;25(3):255-256
    Sheng-Yiao Lin, No. 100, Tzyou 1st Road, Kaohsiung 807, Taiwan;
    Dear Editor, Bullous pemphigoid (BP), a relatively common autoimmune blistering disease in the elderly, is characterized by large, tense bullae on urticarial, erythematous, or normal skin. However, atypical BP with polymorphic clinical presentations is rarely encountered, leading to misdiagnosis and delayed treatments (1). BP with lesions resembling erythema gyratum repens or figurate erythema has been regarded as a paraneoplastic phenomenon (1). Read More

    Characteristics of pediatric recurrent erythema multiforme.
    Pediatr Dermatol 2018 Jan 12;35(1):97-103. Epub 2017 Dec 12.
    Section of Pediatric Dermatology, Departments of Dermatology and Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA.
    Background: Erythema multiforme (EM) is an acute condition characterized by distinctive target lesions of the skin often accompanied by mucosal ulcers. A subset of individuals experience frequent episodes of recurrent EM, which is rare and poorly understood, especially in children.

    Objective: To characterize clinical features, laboratory findings, and treatment responses of pediatric recurrent EM. Read More

    Immunohistopathological Findings of Severe Cutaneous Adverse Drug Reactions.
    J Immunol Res 2017 31;2017:6928363. Epub 2017 Oct 31.
    Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata 951-8510, Japan.
    Diagnosis of severe cutaneous adverse drug reactions should involve immunohistopathological examination, which gives insight into the pathomechanisms of these disorders. The characteristic histological findings of erythema multiforme (EM), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) provide conclusive evidence demonstrating that SJS/TEN can be distinguished from EM. Established SJS/TEN shows full-thickness, extensive keratinocyte necrosis that develops into subepidermal bullae. Read More

    A Review of the Effectiveness and Side-Effects of Fluocinolone Acetonide 0.1% in the Treatment of Oral Mucosal Diseases.
    Acta Stomatol Croat 2017 Sep;51(3):240-247
    Oral Medicine Department, Faculty of Dentistry Chulalongkorn University Bangkok, Thailand.
    Topical steroids have been widely used in the treatment of symptomatic oral lesions to reduce pain and inflammation. Potent topical steroids such as clobetasol propionate, fluocinolone acetonide (FA), and fluocinonide have been widely used in the treatment of severe oral mucosal lesions. Many reports have demonstrated that these steroids were effective in treating oral lesions with only minor side-effects. Read More

    Oral Manifestation in Patients diagnosed with Dermatological Diseases.
    J Contemp Dent Pract 2017 Dec 1;18(12):1153-1158. Epub 2017 Dec 1.
    Department of Oral Pathology and Microbiology, M. A. Rangoonwala College of Dental Sciences & Research Centre Pune, Maharashtra, India.
    Aim: This study aimed to estimate the frequency of oral lesions in dermatological diseased patients attending the outpatient department of Pravara Rural Medical and Dental College and Hospital, Pravara Institute of Medical Sciences (Deemed University), Loni, Ahmednagar, Maharashtra, India, and the Department of Dermatology at Medical College, Ahmednagar, Maharashtra, India.

    Materials And Methods: A cross-sectional hospital-based study was conducted in Loni from October 2013 to January 2014. A total of 310 patients (mean age 37. Read More

    Current Perspectives on Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.
    Clin Rev Allergy Immunol 2018 Feb;54(1):147-176
    Unité d'allergologie, Service d'immunologie et d'allergologie, Hôpitaux Universitaires de Genève HUG, Genève, Switzerland.
    Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are considered a delayed-type hypersensitivity reaction to drugs. They represent true medical emergencies and an early recognition and appropriate management is decisive for the survival. SJS/TEN manifest with an "influenza-like" prodromal phase (malaise, fever), followed by painful cutaneous and mucous membrane (ocular, oral, and genital) lesions, and other systemic symptoms. Read More

    Atypical Hand, Foot, and Mouth Disease Caused by Coxsackievirus A6 in Denmark: A Diagnostic Mimicker.
    Acta Derm Venereol 2018 Mar;98(3):350-354
    Department of Dermatology and Allergy Centre, Odense University Hospital, DK-5000 Odense C, Denmark.
    Since 2008, outbreaks of atypical hand, foot, and mouth disease (HFMD) in children and adults have been reported worldwide. The majority of these outbreaks are caused by a new lineage of Coxsackie virus A6 (CV-A6) presenting a more severe clinical phenotype than the classical childhood HFMD caused by CV-A16. Between June 2014 and January 2016, 23 cases of atypical HFMD disease presented at a Dermatology Department at a regional University Hospital in Denmark. Read More

    [News Skin lesions : a case report of fixed drug eruption].
    Rev Med Brux 2017 ;38(5):439-441
    Service de Gériatrie, Hôpital André Vésale, C.H.U. de Charleroi.
    Fixed drug eruption is an erythematous eruption of one or more centimetric rounded or oval lesions well demarcated, recurrent at the same place and leaving a residual purple pigmentation. Diagnosis is clinical. Skin biopsy is not essential except in doubtful cases (eg bullous drug eruption can simulate Lyell Syndrome or mucosal reminiscent of erythema multiforme). Read More

    Stevens-Johnson syndrome and toxic epidermal necrolysis: epidemiological and clinical outcomes analysis in public hospitals.
    An Bras Dermatol 2017 Sep-Oct;92(5):661-667
    Stricto Sensu Postgraduate Program In Health Sciences of Fundação de Ensino e Pesquisa em Ciências da Saúde (FEPECS) - Brasília (DF), Brazil.
    Background: Adverse drug reactions are harmful and involuntary responses to drugs that occur at doses normally used for a given condition. Among them are Stevens-Johnson syndrome and toxic epidermal necrolysis, both rare and potentially fatal conditions.

    Objectives: To analyze the epidemiological and clinical characteristics related to patients diagnosed with Stevens-Johnson syndrome and toxic epidermal necrolysis in public hospitals in the Federal District - Brazil. Read More

    [A case of Orf disease complicated by erythema multiforme].
    Arch Pediatr 2017 Dec 16;24(12):1241-1243. Epub 2017 Nov 16.
    Service d'accueil des urgences, American Memorial Hospital, CHU de Reims, 47, rue Cognacq-Jay, 51100 Reims, France.
    Ecthyma contagiosum, or Orf, is a specific infection of small ruminants accidentally reaching humans. Few cases have been reported in the literature to date. We report here a case of ecthyma contagiosum occurred in a 9-year-old girl after contact with a flock of ecthyma sheep. Read More

    Milker's nodule: an occupational infection and threat to the immunocompromised.
    J Eur Acad Dermatol Venereol 2018 Apr 5;32(4):537-541. Epub 2018 Jan 5.
    Dermatology Department, New Jersey Medical School, Rutgers University School of Public Affairs and Administration, Newark, NJ, USA.
    Milker's nodule virus, also called paravaccinia virus, is a DNA virus of the parapoxvirus genus transmitted from infected cows to humans. It results from contact with cattle, cattle by-products or fomites. Classified as an occupational disorder, those at risk of exposure include farmers, butchers and agricultural tourists. Read More

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