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J Virol 2021 May 5. Epub 2021 May 5.

Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA

Parvovirus B19 (B19V) infection causes diseases in humans ranging from the mild to severe hematological disorders. The unique region of the minor structural protein VP1 (VP1u) of 227 amino acids harbors strong neutralizing epitopes which elicit dominant immune responses in patients. Recent studies have shown that the VP1u selectively binds to and enters B19V permissive cells through an unknown cellular proteinaceous receptor. Read More

BMJ Case Rep 2021 Apr 20;14(4). Epub 2021 Apr 20.

Department of Paediatric Infectious Diseases, Imperial College Healthcare NHS Trust, London, UK.

We present a HIV-infected patient who developed severe anaemia due to chronic parvovirus B19 infection and subsequently had an unplanned pregnancy. This is in the context of poor adherence to antiretroviral therapy and significant immunosuppression; there was a delay in diagnosis of chronic parvovirus infection due to attribution of anaemia to HIV. She received immunoglobulin therapy and effective antiretroviral therapy, with reduction in parvovirus load and improvement in anaemia. Read More

Viruses 2021 03 24;13(4). Epub 2021 Mar 24.

Biomedical Research Center, Member of QU Health, Qatar University, Doha, Qatar.

Human parvovirus (B19V) is the causative agent of erythema infectiosum in children and is linked to a wide range of clinical manifestations. Studies related to B19V prevalence in the Middle East and North Africa (MENA) region and other parts of Asia are very scarce. The objectives of this study were to estimate the seroprevalence (anti-B19V IgM and IgG), the viremia rate (B19V DNA), and the circulating genotypes of B19V among blood donors in Qatar. Read More

J Dermatol 2021 May 18;48(5):e236-e237. Epub 2021 Mar 18.

Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan.

Sci Rep 2021 Jan 13;11(1):1225. Epub 2021 Jan 13.

Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.

Human parvovirus B19 (B19V) infection is not notifiable in Belarus and its most common clinical presentation erythema infectiosum (EI) is often difficult to distinguish from other exanthematous diseases. The objective of this study was to provide comprehensive data about EI epidemiology in Belarus based on the serological and molecular investigation of samples from measles and rubella discarded cases collected between 2005 and 2019. Overall, 4919 sera were investigated for IgM antibodies against B19V and the positive cases were analysed according to year, season and age. Read More

N Engl J Med 2021 Jan;384(1):61-68

From Women and Infants' Hospital (M. Rudder, M. Russo) and Rhode Island Hospital (C.E.V.), Warren Alpert Medical School of Brown University, Providence.

Ter Arkh 2020 Sep 1;92(7):100-103. Epub 2020 Sep 1.

Loginov Moscow Clinical Scientific Center.

Here we provide a review of the literature and a description of our own clinical case. The patient was a 32-year-old woman who had been infected with HIV for 6 years without antiretroviral therapy. The test results showed CD4 87 cells/l, viral load 3750 copies/ml. Read More

Trop Med Health 2020 Dec 2;48(1):96. Epub 2020 Dec 2.

Infectious and Tropical Diseases Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

Background: Parvovirus B19 is the causative agent for erythema infectiosum, and also as a potentially life-threatening infectious agent, it is mainly presented in high erythrocyte turnover patients. Sickle cell disease (SCD) is an inherited monogenic hematological disorder resulting from the mutations in the hemoglobin β-chain gene. Thalassemia is a hereditary hematological syndrome that happens in consequence of deficiencies in the production of one or more globin chains. Read More

Nat Rev Cardiol 2021 03 12;18(3):169-193. Epub 2020 Oct 12.

Berlin Institute of Health Center for Regenerative Therapies (BCRT), Charité - University Medicine Berlin, Campus Virchow Clinic, Berlin, Germany.

Inflammatory cardiomyopathy, characterized by inflammatory cell infiltration into the myocardium and a high risk of deteriorating cardiac function, has a heterogeneous aetiology. Inflammatory cardiomyopathy is predominantly mediated by viral infection, but can also be induced by bacterial, protozoal or fungal infections as well as a wide variety of toxic substances and drugs and systemic immune-mediated diseases. Despite extensive research, inflammatory cardiomyopathy complicated by left ventricular dysfunction, heart failure or arrhythmia is associated with a poor prognosis. Read More

Int J Occup Med Environ Health 2020 Oct 29;33(6):733-756. Epub 2020 Sep 29.

French Research and Safety Institute for the Prevention of Occupational Accidents and Diseases (INRS), Paris, France (Department of Expertise and Technical Advice).

Childcare providers are overwhelmingly women of childbearing age. Occupational risks in this sector include exposure to biological (infectious) or physical (standing, carrying loads) hazards, many of which are associated with adverse pregnancy outcomes such as children with congenital infections, low birth weight or prematurity. Here, the authors examined literature on pregnancy outcomes and infectious hazards related to employment in daycare settings. Read More

Sci Rep 2020 09 24;10(1):15695. Epub 2020 Sep 24.

Department of Infectious Disease Epidemiology, Bernhard Nocht Institute for Tropical Medicine, 20359, Hamburg, Germany.

Parvovirus B19 (B19V) occurs globally and can cause severe anaemia. The role of co-infections with Plasmodium falciparum (P. falciparum) has been controversially discussed. Read More

Pediatr Dermatol 2020 Nov 6;37(6):1179-1180. Epub 2020 Sep 6.

Department of Dermatology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Parvovirus B19 is the most common causative agent of papular-purpuric gloves and socks syndrome (PPGSS), an often-underreported condition in the pediatric population. Classically, PPGSS presents with a papular-purpuric and at times petechial eruption of the hands and feet. (Dermatology. Read More

Prenat Diagn 2020 12 30;40(13):1722-1731. Epub 2020 Sep 30.

Department of Perinatal Medicine, Mercy Hospital for Women, Melbourne, Victoria, Australia.

Parvovirus B19 (B19V) infection is well known for its mild, self-limiting clinical presentations in children, such as erythema infectiosum. Approximately 40% of women of childbearing age are susceptible to B19V infection. While maternal B19V infection usually has a good prognosis, B19V can cause severe fetal anaemia and pregnancy loss due to its ability to suppress erythroid progenitor cells. Read More

Cureus 2020 Jun 26;12(6):e8854. Epub 2020 Jun 26.

Paediatrics, Al Jalila Children's Speciality Hospital, Dubai, ARE.

Most of the parvovirus infections in humans are benign. Clinical manifestations of parvovirus B19 infections in children vary from erythema infectiosum in healthy children to aplastic crisis in patients with hematological disorders (such as sickle cell disease) and immunocompromised patients. Parvovirus B19 infects the erythroid progenitor cell in the bone marrow and causes transient erythroblastopenia. Read More

BMC Infect Dis 2020 Jul 11;20(1):496. Epub 2020 Jul 11.

Department of Virology, Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail), UMR_S 1085, F-35000, Rennes, France.

Background: Despite high overall population vaccine coverage, identified clusters of persons refraining from vaccination interfere with pursued measles elimination. Clinical diagnosis of measles is often obvious due to its typical rash. Yet, febrile rashes may occur during many viral infections. Read More

Curr Health Sci J 2020 Jan-Mar;46(1):16-22. Epub 2020 Mar 31.

Department of Neurology, Al Noor Specialists Hospital, Makkah, Saudi Arabia.

Human parvovirus (B19) infection causes Erythema infectiosum in persons with other hematological disorders like aplastic anemia and complications such as hydrops fetalis, spontaneous abortions. This study aimed to determine the prevalence of IgG and IgM antibodies in B19 infected neurological patients and to assess possible transmission related risk factors. This cross-sectional descriptive study comprised 140 neurological patients. Read More

Sheng Wu Gong Cheng Xue Bao 2020 May;36(5):879-890

College of Medical, Hubei University of Arts and Science, Xiangyang 441053, Hubei, China.

Human parvovirus B19 (B19 virus) is one of the two parvoviruses that cause human diseases. As an important pathogen to humans, it causes infectious erythema in children, acute aplastic anemia, fetal edema and death. In this review, we focus on the recent advances in the molecular virology of B19V, such as viral genotypes, viral receptor, genomic features and viral replication, viral transcription and post-transcription regulation, viral nonstructural and structural protein features and functions, viral diagnosis and antiviral agents, to provide reference for further study of B19 pathogenesis mechanisms, treatment and diagnostic strategies. Read More

Transfus Med 2020 08 22;30(4):243-244. Epub 2020 Jun 22.

Scientific Affairs, American Red Cross, Gaithersburg, Maryland, USA.

Bull Hosp Jt Dis (2013) 2020 Jun;78(2):140-143

Human parvovirus B19 (B19V) is well known for its infectivity. However, the risk for communicability to previously unexposed healthcare professionals is controversial. We report here a small outbreak of B19V infection among physicians and family members in an adult rheumatology practice that occurred after providing care for a patient with B19V arthropathy. Read More

Forensic Sci Med Pathol 2020 09 3;16(3):498-503. Epub 2020 Jun 3.

Medical Faculty, Institute of Legal Medicine, University of Cologne, Melatengürtel 60-62, 50823, Cologne, Germany.

We present a case of a 20-year-old man who suffered from Kawasaki disease (KD) associated with a florid parvovirus infection, and who died suddenly from thrombotic occlusion of the coronary arteries. The autopsy revealed several aneurysms of the coronary arteries, a chronic vasculitis and a myofibroblast proliferation leading to focal luminal narrowing. The inflammatory response as well as the detection of the viral particles by PCR in blood and in the lesional tissue demonstrated a possible cause by Parvovirus infection. Read More

Transplant Proc 2020 Jun 8;52(5):1619-1622. Epub 2020 May 8.

Renal Transplant Unit, AO Brotzu, Cagliari, Italy.

Background: The prevalence of parvovirus B19 infection in renal transplantation ranges from 2% to 30%. The age and immune status of the patient influence the severity of the clinical picture. A diagnosis is made by taking as evidence the giant proerythroblasts on a bone marrow sample and the parvovirus B19 viral replication with a polymerase chain reaction (PCR) technique at the blood level. Read More

Transplant Proc 2020 Oct 8;52(8):2530-2532. Epub 2020 Apr 8.

Department of Internal Medicine, Clinic of Nephrology, Hypertension and Internal Diseases of the University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.

Acquired pure red cell aplasia (PRCA) is characterized by severe normocytic (rarely macrocytic) and normochromic anemia, a low reticulocytes count in peripheral blood, and near absence of erythroid precursors in the bone marrow, with a normal level of erythropoietin. We describe a case of the kidney transplant recipient, diagnosed with PRCA induced with parvovirus B19 infection. Our case demonstrates that although this complication is rare, it should be considered in a differential diagnosis of anemia diagnostics in immunocompromised patients. Read More

Clin Dermatol 2020 Jan - Feb;38(1):35-41. Epub 2019 Oct 25.

Sector of Dermatology and Post-Graduation Course in Dermatology, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Brazil. Electronic address:

A rash is a disseminated eruption of cutaneous lesions with great variation in appearance, cause, and severity. When the physician is facing a rash, the history and physical examination of the patient are extremely important for the identification of the disease and its causal agent. There are various causes for a rash, which may be infectious, allergic, or rheumatologic, besides many others. Read More

Med Clin (Barc) 2020 07 3;155(1):26-29. Epub 2020 Mar 3.

Departamento de Dermatología, Clínica Universidad de Navarra, Pamplona, España. Electronic address:

Introduction: Parvovirus B19 (PVB19) infection has a high incidence and worldwide distribution. It has a broad clinical spectrum, with skin, joint and haematological manifestations being the most common. The objective of this study was to determine the epidemiology and clinical-analytical manifestations of acute PVB19 infection. Read More

Med Clin (Barc) 2021 05 3;156(9):472-473. Epub 2020 Mar 3.

Servicio de Anatomía Patológica, Hospital Infanta Margarita, Cabra, Córdoba, España.

MSMR 2020 Feb;27(2):30-31

Br J Haematol 2020 06 23;189(5):800. Epub 2020 Feb 23.

UGC de Hematología, Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS/CSIC/CIBERONC), Universidad de Sevilla, Sevilla, Spain.

Am J Hematol 2020 08 5;95(8):990-991. Epub 2020 Mar 5.

Centre for Haematology, St Mary's Hospital campus of Imperial College Faculty of Medicine, St Mary's Hospital, London, UK.

Indian J Pediatr 2020 08 8;87(8):648-649. Epub 2020 Feb 8.

Department of Pediatrics, Pt B D Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, 124001, India.

J Pediatr Hematol Oncol 2020 05;42(4):e213-e218

Department of Hepatitis and AIDS, Pasteur Institute of Iran, Tehran, Iran.

Objective: Blood-derived products from patient with hemophilia treated by factor VIII concentrates are potential sources of transfusion-transmitted infections, including human immunodeficiency virus, hepatitis, human pegivirus-1 (HPgV-1), B19 virus, and also human hepegivirus-1 (HHpgV-1). In the current study, we investigated the impact of blood transfusion on the prevalence of HHpgV-1, HPgV-1, and B19 virus in plasma of Iranian patient with hemophilia after direct-acting antiviral treatment of hepatitis C virus (HCV) infections for the first time.

Materials And Methods: A total of 170 patients with hemophilia who received direct-acting antivirals were enrolled in this study. Read More