Search Our Scientific Publications & Authors

Clin Dermatol 2020 Jan - Feb;38(1):35-41. Epub 2019 Oct 25.

Sector of Dermatology and Post-Graduation Course in Dermatology, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Brazil. Electronic address:

A rash is a disseminated eruption of cutaneous lesions with great variation in appearance, cause, and severity. When the physician is facing a rash, the history and physical examination of the patient are extremely important for the identification of the disease and its causal agent. There are various causes for a rash, which may be infectious, allergic, or rheumatologic, besides many others. Read More

Biomed Res Int 2019 9;2019:2757450. Epub 2019 Dec 9.

Faculty of Medicine, University of Khartoum, Khartoum, Sudan.

Background: Parvovirus B19 (B19 V) infection had been reported to be more frequent with serious clinical outcomes in patients with sickle cell disease (SCD) than in the general population. There is a wide variation in data among the existing literature regarding the seroprevalence of B19 V in patients with SCD. These data require further summary and analyses for better accuracy. Read More

Clin Lab 2019 Dec;65(12)

Background: Parvoviruses are small DNA viruses causing erythema infectiosum, which is known as the fifth disease. The aim of this study was to investigate the presence of Parvovirus B19 DNA by Real-Time-PCR retrospectively in clinical samples of children diagnosed as acute leukemia and aplastic anemia when investigating the cause of pancytopenia and to investigate its relationship with the clinical manifestations.

Methods: The study samples were collected between March 2014 and March 2018 in Gazi University, Faculty of Medicine, Department of Pediatric Hematology. Read More

Medicine (Baltimore) 2019 Sep;98(36):e17040

Service of Nephrology and Hypertension.

Rationale: Syphilis can share clinical features with autoimmune diseases, such as cutaneous Lupus or rheumatoid arthritis. Moreover, secondary syphilis can have visceral involvement, thus affecting the kidney. Syphilitic nephropathy causes nephrotic syndrome with a classic membranous pattern. Read More

Transpl Infect Dis 2019 Dec 21;21(6):e13164. Epub 2019 Sep 21.

Department of Nephrology, Post graduate Institute of Medical Education and Research, Chandigarh, India.

Impaired cell-mediated, as well as antibody-mediated immunity predisposes a renal transplant recipient to a wide variety of atypical infection. With an increasing number of re-transplant, the balance between immunosuppression and the risk of recurrent disease poses a clinical and therapeutic challenge. Here, we report a successful re-transplantation in a case of parvovirus B19 infection leading to anaemia and collapsing glomerulopathy in the allograft managed with intravenous immunoglobulin (IVIG) and reduction of immunosuppression. Read More

Rev Invest Clin 2019 ;71(4):265-274

Department of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

Background: There is no specific antiviral treatment for parvovirus B19 (PVB19) infection.

Objective: The objective of this study was to study the treatment and outcome of PVB19 infection in kidney transplant recipients (KTR) at our institution, and cases published in the medical literature.

Methods: We conducted a retrospective review of PVB19 infection in KTR at an academic medical center over a 16-year period and summarized the data on its treatment and outcome in 120 KTR in the medical literature. Read More

Hematol Oncol 2019 Oct 25;37(4):483-486. Epub 2019 Aug 25.

Institute of Pediatric Hematology and Oncology, Hospices Civils de Lyon, Claude Bernard Lyon I University, Lyon, France.

In absence of red blood cells disease or immune defect, parvovirus B19 (PVB-19) is usually considered as a benign condition. Here, we report the case of a 10-year-old boy, previously healthy, presenting with a PVB-19 infection revealed by a bicytopenia and a voluminous axillary adenopathy. Pathophysiology examination showed reactional lymphoid population. Read More

Arch Virol 2019 Nov 10;164(11):2775-2781. Epub 2019 Aug 10.

Hospices Civils de Lyon, Laboratoire de Virologie, Institut des Agents Infectieux, Centre de Biologie et de Pathologie Nord, 103, grande rue de la Croix-Rousse, 69 317, Lyon cedex 04, France.

Diagnosis and epidemiological analysis of human parvovirus B19 (hB19V) infections are essential for disease management in severely ill patients. This study aimed to evaluate the performance of an optimized NS1-VP1u nested PCR for detection and sequencing of viruses in clinical samples using 224 clinical and five reference samples. PCR sensitivity, specificity, and positive and negative predictive values were perfect (100%). Read More

J Assoc Physicians India 2018 Aug;66(8):102

Head of Department, Bombay Hospital, Mumbai, Maharashtra.

Kardiol Pol 2019 Aug 9;77(9):875-877. Epub 2019 Jul 9.

Department of Cardiovascular Surgery and Transplantology, Institute of Cardiology, Jagiellonian University Medical College, Kraków, Poland

J Microbiol Immunol Infect 2019 Aug 19;52(4):534-541. Epub 2019 Jun 19.

Division of Pediatric Infectious Diseases, Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

Background/purpose: The clinical presentations of parvovirus B19 in patients with underlying diseases have greater diversity than previously healthy patients. We retrospectively identified patients with polymerase chain reaction (PCR)-confirmed parvovirus B19 infection in attempt to describe its clinical features especially in these populations.

Methods: From 2009 to 2018, patients with real-time PCR-confirmed parvovirus B19 infection were collected. Read More

Adv Chronic Kidney Dis 2019 05;26(3):207-219

Department of Nephrology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.

Viral infection-associated kidney diseases are an emerging public health issue in both developing and developed countries. Many new viruses have emerged with new paradigms of kidney injury, either directly through their cytopathic effect or indirectly through immune-mediated glomerulopathy, tubulointerstitial disease, and acute kidney injury as part of multiorgan failure. Herein, we will discuss Parvovirus, which causes glomerulopathy, and Hanta, Ebola, and Dengue viruses, which cause viral hemorrhagic fever and acute kidney injury. Read More

J Clin Virol 2019 08 19;117:5-10. Epub 2019 May 19.

Centre for Immunology of Infectious Diseases and Vaccines, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.

Background: Infections with parvovirus B19 (B19V) have been associated with a wide range of disease manifestations of which erythema infectiosum (fifth disease) in children is most common. Clinical signs following infection of children with B19V can be similar to measles and rubella. Laboratory detection of B19V infections is based on detection of B19V-specific IgM antibodies by enzyme immunoassay (IgM-EIA) and/or B19V DNA by quantitative PCR (qPCR) on blood samples. Read More

Clin Lab 2019 May;65(5)

A pregnant 30-year-old female in the 34th gestational week was admitted at University "Maichin Dom" Hospital prior to childbirth. The patient is diagnosed with β-thalassemia. During laboratory screening hemoglobin of 98 g/L was established. Read More

Transplant Proc 2019 May 7;51(4):1169-1171. Epub 2019 Feb 7.

Department of General Surgery, Atatürk University School of Medicine, Erzurum, Turkey.

Parvovirus B19 infection is common in childhood. The clinical presentations range from benign to life threatening. The literature shows that the clinical presentation is influenced by the patient's age and the presence of chronic disease such as chronic hemolytic disorders and immunosuppressed conditions. Read More

Neurol Sci 2019 Nov 16;40(11):2403-2404. Epub 2019 May 16.

Departamento de Neurologia e Neurocirurgia, Universidade Federal de São Paulo, Rua Napoleão de Barros, 925, 2°andar, Vila Clementino, São Paulo, SP, 04024-002, Brazil.

J Can Chiropr Assoc 2019 Apr;63(1):44-50

Graduate Student, Sports Sciences RCCSS (C).

Objective: To review the epidemiology, etiology, diagnosis and typical management of erythema infectiosum and to illustrate the clinical management of an adult with erythema infectiosum.

Clinical Features: A 38-year-old male complaining of severe global pain, swelling, weakness and stiffness in his shoulders, elbows, knees, and fingers of seven weeks duration.

Intervention And Outcome: The patient was treated with a combination of 1) pharmacological treatment of naprosyn, prednisone, methotrexate, hydroquinone and sulfasalazine, 2) conservative treatment consisting of spinal manipulation, peripheral joint mobilization, acupuncture and low-tech Qi Gong and Tai Chi exercises, and 3) an active physiotherapy program consisting of strengthening exercises, and stationary bike. Read More

An Pediatr (Barc) 2019 May 2;90(5):280-284. Epub 2018 Jul 2.

Laboratorio de Microbiología, Corporació Sanitària, Hospital Universitari Parc Taulí, Sabadell, Barcelona, España.

Introduction: The aetiological agent of erythema infectiosum is Erythrovirus B19 (also known as parvovirus B19), frequently found in children and adolescents, but also associated with arthropathy, aplastic crisis, and abortion in adults.

Material And Methods: A retrospective study of Erythrovirus B19 cases in the years 2010-2015.

Results: Of the 56 cases of Erythrovirus B19 diagnosed, 34 were adults (32 women and 2 men) and 22 younger than 18 years (12 girls and 10 boys). Read More

Int J Environ Res Public Health 2019 04 17;16(8). Epub 2019 Apr 17.

Institute and Policlinic of Occupational and Social Medicine (IPAS), Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.

In this systematic review, we aimed to summarize the evidence on the association between being a daycare educator working with children and the possible increased risk of parvovirus B19 infection compared to the general population. The Medline and Embase databases were searched using a defined search to find studies published since 2000. Two reviewers evaluated the search hits using predefined inclusion and exclusion criteria. Read More

Infect Dis Clin North Am 2019 06 30;33(2):501-521. Epub 2019 Mar 30.

Division of Infectious Diseases and International Medicine, University of Minnesota, 420 Delaware Street SE, MMC250, Minneapolis, MN 55455, USA. Electronic address:

Infections due to adenovirus, polyomaviruses (BK and JC viruses), and parvovirus B19 may not be as common as infections due to other DNA viruses, such as cytomegalovirus in patients with hematological malignancies and the recipients of hematopoietic stem cell transplantation. However, these infections may result in life-threatening diseases that significantly impact patients' recovery, morbidity, and mortality. Treating physicians should be aware of the diseases associated with these viruses, the patient populations at increased risk for complications due to these infections, and the available diagnostic and therapeutic approaches. Read More

Ann Transplant 2019 Mar 5;24:123-131. Epub 2019 Mar 5.

Department of Nephrology Transplantation and Internal Medicine, Pomeranian Medical University, Szczecin, Poland.

BACKGROUND Anemia is present even in long-term observation after kidney transplantation. Observational study results indicate the presence of chronic post-transplantation anemia in 1 in 3 recipients. An extreme form of erythroid line dysfunction is pure red cell aplasia (PRCA). Read More

Expert Rev Mol Diagn 2019 03 26;19(3):259-266. Epub 2019 Feb 26.

a Laboratório de Desenvolvimento Tecnológico em Virologia , Instituto Oswaldo cruz, Fundação Oswaldo Cruz , Rio de Janeiro , Brasil.

Background: Human Parvovirus B19 (B19V) is a common pathogen worldwide. After primary infection, B19V-DNA may permanently persist in non-erythroid tissues, including the liver of patients with acute liver failure (ALF).

Objective: To validate a real-time PCR (qPCR) for the quantification of B19V-DNA, in order to establish a differential diagnosis for B19V infection in ALF patients. Read More

Afr Health Sci 2018 Sep;18(3):496-502

University of Zambia, School of Medicine, Department of Pathology and Microbiology.

Background: Human Parvovirus (B19V) is a small, single-stranded, non-enveloped DNA virus which is pathogenic to humans causing a wide array of clinical complications which include erythema infectiosum, aplastic crisis and hydrops foetalis. It is generally harmless in healthy individuals but may be life threatening in immunocompromised individuals such as patients with sickle cell disease, cancer, HIV and pregnant women. It has been shown to be transmissible by blood transfusion but donor screening for the virus is not yet mandatory in most sub-Saharan African countries including Zambia. Read More

Egypt J Immunol 2018 Jun;25(2):1-10

Department of Rheumatology & Rehabilitation, Faculty of Medicine, Benha University, Benha, Egypt.

Rheumatoid arthritis (RA) is a common chronic inflammatory disease, affecting about 1% of the general population. Conflicting data are available regarding the etiologic association of human parvovirus B19 (B19) infection with RA. This study aimed to determine the prevalence of B19 infection in patients with RA compared to healthy controls and to assess its possible association with disease activity or severity. Read More

JAMA 2019 Jan;321(3):303-304

Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Department of Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, Ohio.

N Engl J Med 2018 Dec;379(24):2361

Universitätsklinikum Carl Gustav Carus, Dresden, Germany

BMC Infect Dis 2018 Dec 7;18(1):631. Epub 2018 Dec 7.

Research and Development, Australian Red Cross Blood Service, Brisbane, Queensland, Australia.

Backgroud: Primate erythroparvovirus 1 (B19V) is a globally ubiquitous DNA virus. Infection results in a variety of clinical presentations including erythema infectiosum in children and arthralgia in adults. There is limited understanding of the seroprevalence of B19V antibodies in the Australian population and therefore of population-wide immunity. Read More

JAMA Dermatol 2018 11;154(11):1356-1357

Institute of Virology, University of Cologne, Cologne, Germany.

Pediatr Dermatol 2018 Nov 19;35(6):e341-e344. Epub 2018 Sep 19.

Dermatology Service, Hospital Ramos Mejía, Buenos Aires, Argentina.

Parvovirus B19 is a DNA virus of the Parvoviridae family. We present four children with unusual exanthems associated with parvovirus infection: a purpuric periflexural pattern, a purpuric vasculitic pattern, and a combination of the two. Read More

Int J Legal Med 2019 Mar 1;133(2):553-560. Epub 2018 Sep 1.

Institute of Forensic Medicine, Ministry of Justice, No.123, Min'an St., Zhonghe Dist., New Taipei City, 235, Taiwan.

Parvovirus B19 (PVB19) commonly infects children and is usually asymptomatic. Lethal outcomes of PVB19 infection are unusual; nevertheless, the two cases reported here are rare examples of PVB19-induced hemophagocytic syndrome and myocarditis in infants and children. The two cases show the indisputable usefulness of immunohistochemistry and in situ hybridization in the detection of PVB19. Read More

Transfus Apher Sci 2018 Oct 1;57(5):646-650. Epub 2018 Aug 1.

Department of Transfusion Medicine, Government Medical College and Hospital, Chandigarh, India.

Objectives: The present study was aimed to find out the prevalence of parvovirus B19  amongst healthy blood donors and blood transfusion recipients so as to determine the feasibility of providing seronegative blood components to vulnerable recipients.

Methods: A total of 1000 samples were studied which included 800 blood donors and 200 transfusion recipients.The transfusion recipients included 100 multitransfused patients and 100 non transfused controls. Read More

Fetal Diagn Ther 2019 20;46(1):1-11. Epub 2018 Jul 20.

Department of Fetal Medicine, Hôpital Armand-Trousseau, Paris, France.

Background: Infection with parvovirus B19 (B19V) during pregnancy may cause severe fetal anemia, hydrops, and fe tal death. Furthermore, neurodevelopmental impairment among survivors may occur despite appropriate prenatal management, including intrauterine transfusion (IUT).

Objectives: Our primary objective was to describe cerebral lesions on MRI in fetuses with severe anemia requiring IUT for B19V infection. Read More

Indian J Med Res 2018 04;147(4):391-399

Sri Sakthi Amma Institute of Biomedical Research, Sri Narayani Hospital & Research Centre, Vellore, India.

Background & Objectives: Human parvovirus B19V (B19V) is known to be associated with erythema infectiosum commonly in children, aplastic crisis, especially in persons with underlying haemolytic disorders, hydrops fetalis in pregnancies and arthritis. This cross-sectional study was aimed to determine the presence of B19V infection in childhood febrile illnesses, association of B19V with arthropathies and in adult patients with end-stage renal disease (ESRD) on dialysis. The genetic diversity among the sequences was also analysed. Read More

Proc Natl Acad Sci U S A 2018 07 2;115(29):7557-7562. Epub 2018 Jul 2.

Center for Pathogen Evolution, Department of Zoology, University of Cambridge, CB2 3EJ Cambridge, United Kingdom;

Human parvovirus B19 (B19V) is a ubiquitous human pathogen associated with a number of conditions, such as fifth disease in children and arthritis and arthralgias in adults. B19V is thought to evolve exceptionally rapidly among DNA viruses, with substitution rates previously estimated to be closer to those typical of RNA viruses. On the basis of genetic sequences up to ∼70 years of age, the most recent common ancestor of all B19V has been dated to the early 1800s, and it has been suggested that genotype 1, the most common B19V genotype, only started circulating in the 1960s. Read More

J Pediatr 2018 11 21;202:327-327.e1. Epub 2018 Jun 21.

Department of Postgraduate Education and Training National Center for Child Health and Development Tokyo, Japan.

Rev Bras Ginecol Obstet 2018 Jun 20;40(6):372-376. Epub 2018 Jun 20.

Department of Obstetrics and Gynecology, Centro Hospitalar Tâmega e Sousa, Porto, Portugal.

Parvovirus B19 has tropism for red line blood cells, causing immune hydrops during pregnancy. A positive anti-Kell Coombs reaction usually happens during pregnancy when there is production of antibodies that target Kell antigens, but cross reactions to other antigens may occur. A 24-year-old Gypsy primigravida, 0 Rhesus positive, presented with persistent isolated hyperthermia for 2 weeks and a positive indirect Coombs test result with anti-Kell antibodies at routine tests. Read More

Pediatrics 2018 06;141(6)

Department of Pediatrics, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.

Parvovirus B19 (PB19) is an important human pathogen that results in a wide spectrum of clinical outcomes, from mild, self-limiting erythema infectiosum in immunocompetent children and arthralgia in adults to lethal cytopenia in immunocompromised patients and intrauterine fetal death. However, there have been few reports of PB19 infection in neonates or young infants (aged 28-90 days), and no previous reports contained descriptions of PB19 infection as a cause of sepsislike syndrome in this age group. We report a case of sepsislike syndrome caused by PB19 infection in a 56-day-old infant whose mother had polyarthralgia at the time of his admission. Read More

Ultrasound Obstet Gynecol 2018 Nov;52(5):569-576

Women's Health and Perinatology Research Group, Department of Clinical Medicine, Faculty of Health Sciences, UiT - The Arctic University of Norway, Tromsø, Norway.

Objective: To explore the outcome of fetuses affected by congenital parvovirus B19 (PB19) infection, with or without signs of hydrops on ultrasound.

Methods: PubMed, EMBASE and CINAHL databases were searched for studies reporting on prenatal diagnosis and outcome of fetal PB19 infection. The outcomes explored were miscarriage, perinatal death (PND), intrauterine death, neonatal death, spontaneous resolution of hydrops or fetal anemia, need for intrauterine transfusion (IUT), resolution of hydrops or anemia after transfusion, fetal loss following transfusion, abnormal brain scan after birth and abnormal neurodevelopmental outcome. Read More

Transplantation 2018 08;102(8):e367-e368

Queensland Heart-Lung Transplant Unit, The Prince Charles Hospital, Brisbane, Queensland, Australia.

BMJ Case Rep 2018 Apr 21;2018. Epub 2018 Apr 21.

Serviço de Pediatria, Departamento da Infância e da Adolescência, Centro Materno Infantil do Norte, Centro Hospitalar e Universitário do Porto, Porto, Portugal.

Klin Padiatr 2018 Oct 16;230(6):330-332. Epub 2018 Apr 16.

Department for Pediatric Hematology and Oncology, University Children's Hospital of Ljubljana, Ljubljana, Slovenia.

Clin Microbiol Infect 2019 Jan 10;25(1):109.e7-109.e12. Epub 2018 Apr 10.

Department of Pathology, Tangdu Hospital, The Fourth Military Medical University, Xi'an 710038, PR China. Electronic address:

Objective: To investigate the association between myasthenia gravis (MG) and human parvovirus B19 (B19V) infection in the thymus.

Methods: The presence of human B19V DNA and protein was assessed in 138 samples-including 68 thymic hyperplasias (39 with MG), 58 thymomas (23 with MG), and 12 normal thymus tissues-using a nested polymerase chain reaction, immunohistochemistry, laser capture microdissection, and sequencing in a double-blinded manner.

Results: B19V DNA was detected mainly in thymic hyperplasia, and the positivity rate (41. Read More

Blood 2018 03;131(12):1388

Lebanese American University Medical Center.

PLoS One 2018 14;13(3):e0194186. Epub 2018 Mar 14.

Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique.

Background: Congenital cytomegalovirus (cCMV) infection is the most prevalent congenital infection acquired worldwide, with higher incidence in developing countries and among HIV-exposed children. Less is known regarding vertical transmission of parvovirus B19 (B19V) and enterovirus (EV). We aimed to assess the prevalence of CMV, B19V and EV vertical transmission and compare results of screening of congenital CMV obtained from two different specimens in a semirural Mozambican maternity. Read More

Mediterr J Hematol Infect Dis 2018 1;10(1):e2018018. Epub 2018 Mar 1.

Department of Pediatrics, Democritus University of Thrace Faculty of Medicine, Alexandroupolis, Thrace, Greece.

Background: Human parvovirus B19 (HPV-B19) is the etiologic agent of erythema infectiosum, of transient aplastic crises in individuals with underlying chronic hemolytic disorders, and of chronic pure red cell aplasia in immunocompromised individuals.

Case Report: We describe a 14-year-old girl with long-standing Evans syndrome, who presented with severe anemia, reticulocytopenia and thrombocytopenia. A bone marrow aspirate revealed severe erythroid hypoplasia along with the presence of giant pronormoblasts, while serological studies and real-time PCR of whole blood were positive for acute parvovirus B19 infection. Read More

N Engl J Med 2018 Feb;378(8):753-760

From the Departments of Medicine (S.J.K., J.S.G., R.K.L., A.L.C.) and Pathology (G.M.E.), Massachusetts General Hospital, and the Departments of Medicine (S.J.K., J.S.G., R.K.L., A.L.C.) and Pathology (G.M.E.), Harvard Medical School - both in Boston.

Pathol Int 2018 Mar 19;68(3):190-195. Epub 2018 Feb 19.

Division of Rheumatology, Department of Internal Medicine, Kanazawa University Graduate School of Medicine, Kanazawa, Japan.

Human parvovirus B19 infection causes a variety of glomerular diseases such as post-infectious acute glomerulonephritis and collapsing glomerulopathy. Although each of these appears independently, it has not been fully determined why parvovirus B19 provokes such a variety of different glomerular phenotypes. Here, we report a 68-year-old Japanese man who showed endocapillary proliferative glomerulonephritis admixed with podocytopathy in association with parvovirus B19 infection. Read More

J Virol 2018 04 28;92(8). Epub 2018 Mar 28.

Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA

Human parvovirus B19 (B19V) expresses a single precursor mRNA (pre-mRNA), which undergoes alternative splicing and alternative polyadenylation to generate 12 viral mRNA transcripts that encode two structural proteins (VP1 and VP2) and three nonstructural proteins (NS1, 7.5-kDa protein, and 11-kDa protein). Splicing at the second 5' donor site (D2 site) of the B19V pre-mRNA is essential for the expression of VP2 and the 11-kDa protein. Read More