Search Our Scientific Publications & Authors

Rinsho Shinkeigaku 2022 Apr 26. Epub 2022 Apr 26.

Department of Neurology, Hyogo Prefectural Awaji Medical Center.

We have reported a case of a 44-year-old woman with anti-signal recognition particle (SRP) antibody-positive immune-mediated necrotizing myopathy triggered by human parvovirus B19 (PVB19) infection. She was admitted to the hospital because of lower leg edema and muscle weakness after erythema infectiosum. Magnetic resonance imaging of the lower extremities revealed high signals in the proximal muscles and subcutaneous edema on STIR. Read More

Clin Ter 2022 Apr;173(2):104-106

Near East University Hospital Radiology Department, Nicosia, Cyprus.

Abstract: Parvovirus B19 infection can be associated with a wide spec-trum of clinical manifestations that mainly depends on the clinical background of the patient. Infection causes severe aplastic effects on bone marrow in immunosuppressive patients. Our patient was using Azathioprine for Crohn Disease when she admitted with malaise and fatigue laboratory tests revealed pancytopenia due to Parvovirus B19 infection . Read More

BMC Infect Dis 2022 Mar 7;22(1):231. Epub 2022 Mar 7.

Center for Cardiac Intensive Care, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Diseases, 2 Anzhen Road, Chaoyang District, Beijing, 100029, China.

Background: Infection with human parvovirus B19 (PB19) is very common in pediatric patients. Symptoms and signs depend on the infected patient's immune and hematopoietic status and can range from an asymptomatic condition to life-threatening disease.

Case Presentation: A 69-year-old man received elective mitral valvular replacement and tricuspid valvuloplasty under cardiopulmonary bypass and suffered acute respiratory distress syndrome on postoperative day 8. Read More

Prague Med Rep 2022 ;123(1):48-55

2nd Neonatal Department and Neonatal Intensive Care Unit, Aristotle University of Thessaloniki, "Papageorgiou" General Hospital of Thessaloniki, Thessaloniki, Greece.

Parvovirus B19 infection in pregnancy may have a poor outcome for the fetus. Ocular anomalies, brain damage with hydrocephalus and central nervous system (CNS) scarring, cleft lip and hypospadias, as well myocarditis and congenital heart disease have been reported. We present a case of a preterm female neonate born with ascites, hydrothorax and congenital diaphragmatic eventration (CDE), with a prenatal diagnosis of congenital diaphragmatic hernia (CDH). Read More

Klin Lab Diagn 2022 Feb;67(2):115-122

Ekaterinburg Research Institute of Viral Infections.

Parvovirus infection (PVI) is widespread, characterized by airborne, bloodborne and vertical transmission routes. Parvovirus B19 (PVB19) exhibits tropism to erythropoietic cells. According to the increased likelihood principle of PVB19 infection and the severity of the consequences, immunocompromised individuals, especially those with hematological manifestations of diseases, are in increased risk group. Read More

J Pediatr Hematol Oncol 2022 03;44(2):40-42

Department of Hematology Oncology and Cellular Therapy, Cohen Children's Medical Center, New Hyde Park, NY.

This retrospective study investigates the relationship between the presence of a documented viral infection in children with sickle cell disease during their first splenic sequestration crisis and their odds of recurrence. Forty-eight children were admitted to our hospital between 2008 and 2018 with a splenic sequestration crisis. Thirty-six had respiratory viral panels done on admission, 13 of whom were positive. Read More

Transfus Clin Biol 2022 May 8;29(2):168-174. Epub 2022 Jan 8.

Urology Department, Urology research institute, West China Hospital, Sichuan University, Chengdu, Sichuan, China; Organ transplantation center, West China Hospital, Sichuan University, Chengdu, Sichuan, China. Electronic address:

Background: There are no optimal diagnostic, treatment and post-infection surveillance strategies for parvovirus B19 infection in solid organ transplantation (SOT) recipients.

Methods: We conducted a retrospective review of all PVB19 infected cases confirmed by qPCR among SOT recipients at our institution over a 3-year period and reviewed the literature from 1990 to 2021.

Results: Eight kidney and two heart transplant patients with refractory anemia had PVB19 infection. Read More

Am J Otolaryngol 2022 Mar-Apr;43(2):103345. Epub 2021 Dec 23.

Department of Endocrinology and Metabolism, Zahedan University of Medical Sciences, Zahedan, Iran.

Background: The incidence of thyroid nodules has increased dramatically in recent decades. Although this increase has been attributed to improved imaging modalities, the question arises as to whether other environmental factors, such as infectious agents are influential.

Methods: Adult patients with newly diagnosed papillary thyroid carcinoma, benign thyroid nodules, and healthy euthyroid controls without nodules; were recruited. Read More

Clin Dermatol 2021 Dec 31. Epub 2021 Dec 31.

Department of Dermatology and Allergy, Technische Universität München, Munich, Germany. Electronic address:

Annular configuration is conspicuous in the clinical manifestation of many skin diseases and can be helpful for the diagnosis and differential diagnosis. Variations may include arciform, ring-form, annular, circinate, serpiginous, gyrated, polycyclic, targeted or figurate forms, in different colors, sizes, and numbers, with various textures and surfaces. In infectious dermatoses, the annular reactions can be specific or nonspecific, while the underlying mechanisms remain largely unknown. Read More

Hemodial Int 2022 Apr 30;26(2):202-206. Epub 2021 Dec 30.

Clinical Pathology Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Introduction: Parvovirus B19V has been shown to be associated with end-stage renal disease (ESRD) with increased risk of post-infection anemia, especially in hemodialysis (HD) patients. This effect may be due to immunosuppression, insufficient erythropoietin, or short lifespan of red blood cells. Therefore, parvovirus infection should be investigated in this group of patients suffering from anemia or pancytopenia. Read More

Front Immunol 2021 14;12:742990. Epub 2021 Dec 14.

Department of Internal Medicine, Medical Intensive Care Unit and Division of Respiratory Diseases, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Background: () can cause acute hepatitis and is attributed to the high mortality of alcoholic hepatitis (AH) infection is generally self-healing in previously healthy people, but it can cause fatal effects in some high-risk groups and increase its virulence and infectivity. Disseminated infection-induced multiple organ dysfunction syndrome (MODS) in patients with AH has not been reported yet. Here, we described viremia in an adult patient with AH accompanied by hemolytic anemia (HA), leading to disseminated infection and secondary MODS, as well as self-limiting infections in seven nurses caring for him. Read More

Front Cell Infect Microbiol 2021 15;11:753970. Epub 2021 Oct 15.

Kidney Disease Center, the First Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, China.

Background: Donor-derived human parvovirus B19 (B19V) infections are rarely reported. Thus, its incidence in kidney transplantation is still unknown due to lack of surveillance studies. Similarly, whether the donor needs to be routinely screened for B19V and whether the kidneys from those with B19V DNAemia could be accepted also remain unknown. Read More

Zhonghua Xue Ye Xue Za Zhi 2021 Aug;42(8):654-659

State Key Laboratory of Experimental Hematology; National Clinical Research Center for Blood Diseases; Children's Blood Disease Diagnosis and Treatment Center, Institute of Hematology & Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.

To retrospectively analyze hemogram and bone marrow characteristics of pediatric patients infected with parvovirus B19 (HPV-B19) after hematopoietic reconstitution following allo-hematopoietic stem cell transplantation. The clinical course of nine patients with HPV-B19 infection, including hemogram and bone marrow smear analysis during infection, were retrospectively analyzed. Despite the hematological heterogeneity, all patients exhibited reduced hemoglobin levels accompanied by reticulocytes. Read More

J Trop Pediatr 2021 08;67(4)

Instituto de Pesquisa Clínica Carlos Borborema, Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Amazonas 69040-000, Brazil.

An increasing number of reports have described human parvovirus B19 infection in association with a variety of neurological manifestations, especially in children. This study assessed the clinical and laboratory outcomes found in a case series of immunocompetent children who tested positive for parvovirus B19 by qualitative polymerase chain reaction assays of cerebrospinal fluid, in a tertiary referral center in the western Brazilian Amazon. We screened 178 children with clinically diagnosed central nervous system infections (meningoencephalitis). Read More

Eur J Obstet Gynecol Reprod Biol 2021 Sep 28;264:358-362. Epub 2021 Jul 28.

Sheffield Teaching Hospital, 8 Beech Hill Road, Sheffield, South Yorkshire S10 2SB, UK. Electronic address:

Parvovirus B19 (B19V) is a widespread infection that may affect 1-5% of pregnant women, mainly with normal pregnancy outcome. Vertical transmission occurs in 33-51% of cases of maternal infection. B19V infection is an important cause of fetal morbidity (fetal anaemia and non-immune hydrops) and mortality, predominantly in the second trimester. Read More

Pediatr Int 2022 Jan;64(1):e14958

Department of Healthcare Epidemiology, School of Public Health in the Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Background: To combat the coronavirus disease 2019 pandemic, many countries, including Japan, implemented policies limiting social activities and encouraging preventive behaviors. This study examines the influence of such policies on the trends of 10 infectious pediatric diseases: pharyngoconjunctival fever; group A streptococcal pharyngitis; infectious gastroenteritis; chickenpox; erythema infectiosum; hand, foot, and mouth disease; herpangina; respiratory syncytial virus; exanthem subitum; and mumps.

Methods: The research adopted a retrospective cohort study design. Read More

Diagn Microbiol Infect Dis 2021 Nov 16;101(3):115489. Epub 2021 Jul 16.

Laboratory of Medical Microbiology, Ghent University Hospital, Gent, Belgium. Electronic address:

Background: Parvovirus B19 is a pathogenic virus often diagnosed by serology, yet little is known about analytical performance of commercial enzyme immunoassays (EIAs).

Objective: To investigate performance of 4 EIAs for parvovirus B19 IgM and IgG: Liaison, Euroimmun, Mikrogen and Virion/Serion.

Study Design: To compare 4 EIAs to Biotrin's ELISA on 168 samples and determine consensus score for discordant samples using Mikrogen's confirmatory line assay. Read More

BMJ Case Rep 2021 Jul 21;14(7). Epub 2021 Jul 21.

Hematology and Oncology, Henry Ford Hospital, Detroit, Michigan, USA.

BMJ Case Rep 2021 Jul 12;14(7). Epub 2021 Jul 12.

Department of Rheumatology, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan.

J Pediatr Health Care 2022 Mar-Apr;36(2):165-169. Epub 2021 Jul 1.

Transplant Cardiologist, Phoenix Children's Hospital, Phoenix, AZ.

J Midwifery Womens Health 2021 May 8;66(3):385-390. Epub 2021 Jun 8.

Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Alpert Medical School of Brown University, Providence, Rhode Island.

Parvovirus B19 has been identified as the cause of erythema infectiosum, a common childhood illness. Also known as fifth disease, this virus is highly contagious among school-age children, especially during the winter months when outbreaks within classrooms are widespread. The majority of adults have had the infection in childhood and are immune to recurrence. Read More

J Virol 2021 May 5. Epub 2021 May 5.

Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA

Parvovirus B19 (B19V) infection causes diseases in humans ranging from the mild to severe hematological disorders. The unique region of the minor structural protein VP1 (VP1u) of 227 amino acids harbors strong neutralizing epitopes which elicit dominant immune responses in patients. Recent studies have shown that the VP1u selectively binds to and enters B19V permissive cells through an unknown cellular proteinaceous receptor. Read More

Acta Biomed 2021 04 30;92(S1):e2021129. Epub 2021 Apr 30.

Azienda Ospedaliero-Universitaria di Parma.

Parvovirus B19 (PVB19) is a small DNA virus that causes the fifth disease in children; however it can also affect adults. The infection can be asymptomatic in about a quarter of healthy subjects. Typical clinical manifestations are: short lived fever accompanied by asthenia, myalgias and pharyngodynia; symmetrical acute polyarthritis; megalo-erytema in child; maculopulotic rash and/or fleeting purpuric at the extremities in adult; adenopathies in the cervical area. Read More

Br J Haematol 2021 05 30;193(4):703-704. Epub 2021 Apr 30.

Department of Woman's and Child's Health, University of Padua, Padua, Italy.

Br J Haematol 2021 05 25;193(4):827-840. Epub 2021 Apr 25.

Department of Clinical and Chemical Pathology, Faculty of Medicine, Sohag University, Sohag, Egypt.

A total of 244 patients with hereditary haemolytic anaemias (HHA) were screened for acute symptomatic human parvovirus B19 infection (HPV-B19) in a prospective study. To assess the risks associated with HPV-B19 infection, patients were classified into Group I and Group II according to presence or absence (symptoms, signs and specific serology) of acute HPV-B19 infection respectively. In all, 131 (53·7%) patients had β-thalassaemia, 75 (30·7%) hereditary spherocytosis (HS), 27 (11·1%) sickle cell anaemia (SCA) and 11 (4·5%) glucose-6-phosphate dehydrogenase (G6PD) deficiency. Read More

BMJ Case Rep 2021 Apr 20;14(4). Epub 2021 Apr 20.

Department of Paediatric Infectious Diseases, Imperial College Healthcare NHS Trust, London, UK.

We present a HIV-infected patient who developed severe anaemia due to chronic parvovirus B19 infection and subsequently had an unplanned pregnancy. This is in the context of poor adherence to antiretroviral therapy and significant immunosuppression; there was a delay in diagnosis of chronic parvovirus infection due to attribution of anaemia to HIV. She received immunoglobulin therapy and effective antiretroviral therapy, with reduction in parvovirus load and improvement in anaemia. Read More

Rev Chilena Infectol 2020 Dec;37(6):775-779

Departamento de Anatomía patológica, Hospital Dr. Eduardo Pereira, Valparaíso, Chile.

Acute parvovirus B19 infection is a self-limiting disease in patients with normal immune response. However, in patients with blood dyscrasias, it is possible to present with an aplastic crisis. We present the case of a 48-year-old man who had developed an aplastic crisis as a result of an acute parvovirus B19 infection with an undiagnosed hereditary spherocytosis. Read More

Rev Chilena Infectol 2021 Feb;38(1):114-118

Servicio de Hematología y Hemoterapia, Hospital de Barbastro, España.

Human parvovirus B19 infection is one of the common complications of patients diagnosed with Sickle cell disease (SCD). Parvovirus infections are characterized by a severe anemia with reticulocytopenia, sometimes presenting with other clinical manifestations. The infection can occur simultaneously in patient's cohabitants also diagnosed with SCD. Read More

Viruses 2021 03 24;13(4). Epub 2021 Mar 24.

Biomedical Research Center, Member of QU Health, Qatar University, Doha, Qatar.

Human parvovirus (B19V) is the causative agent of erythema infectiosum in children and is linked to a wide range of clinical manifestations. Studies related to B19V prevalence in the Middle East and North Africa (MENA) region and other parts of Asia are very scarce. The objectives of this study were to estimate the seroprevalence (anti-B19V IgM and IgG), the viremia rate (B19V DNA), and the circulating genotypes of B19V among blood donors in Qatar. Read More

J Dermatol 2021 May 18;48(5):e236-e237. Epub 2021 Mar 18.

Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan.