Search our Database of Scientific Publications and Authors

I’m looking for a

    1208 results match your criteria Erythema Infectiosum Fifth Disease

    1 OF 25

    Parvovirus B19-triggered Acute Hemolytic Anemia and Thrombocytopenia in a Child with Evans Syndrome.
    Mediterr J Hematol Infect Dis 2018 1;10(1):e2018018. Epub 2018 Mar 1.
    Department of Pediatrics, Democritus University of Thrace Faculty of Medicine, Alexandroupolis, Thrace, Greece.
    Background: Human parvovirus B19 (HPV-B19) is the etiologic agent of erythema infectiosum, of transient aplastic crises in individuals with underlying chronic hemolytic disorders, and of chronic pure red cell aplasia in immunocompromised individuals.

    Case Report: We describe a 14-year-old girl with long-standing Evans syndrome, who presented with severe anemia, reticulocytopenia and thrombocytopenia. A bone marrow aspirate revealed severe erythroid hypoplasia along with the presence of giant pronormoblasts, while serological studies and real-time PCR of whole blood were positive for acute parvovirus B19 infection. Read More

    Case 6-2018: A 35-Year-Old Woman with Headache, Subjective Fever, and Anemia.
    N Engl J Med 2018 Feb;378(8):753-760
    From the Departments of Medicine (S.J.K., J.S.G., R.K.L., A.L.C.) and Pathology (G.M.E.), Massachusetts General Hospital, and the Departments of Medicine (S.J.K., J.S.G., R.K.L., A.L.C.) and Pathology (G.M.E.), Harvard Medical School - both in Boston.

    Post-infectious acute glomerulonephritis with podocytopathy induced by parvovirus B19 infection.
    Pathol Int 2018 Mar 19;68(3):190-195. Epub 2018 Feb 19.
    Division of Rheumatology, Department of Internal Medicine, Kanazawa University Graduate School of Medicine, Kanazawa, Japan.
    Human parvovirus B19 infection causes a variety of glomerular diseases such as post-infectious acute glomerulonephritis and collapsing glomerulopathy. Although each of these appears independently, it has not been fully determined why parvovirus B19 provokes such a variety of different glomerular phenotypes. Here, we report a 68-year-old Japanese man who showed endocapillary proliferative glomerulonephritis admixed with podocytopathy in association with parvovirus B19 infection. Read More

    RNA Binding Protein RBM38 Regulates Expression of the 11-Kilodalton Protein of Parvovirus B19, Which Facilitates Viral DNA Replication.
    J Virol 2018 04 28;92(8). Epub 2018 Mar 28.
    Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA
    Human parvovirus B19 (B19V) expresses a single precursor mRNA (pre-mRNA), which undergoes alternative splicing and alternative polyadenylation to generate 12 viral mRNA transcripts that encode two structural proteins (VP1 and VP2) and three nonstructural proteins (NS1, 7.5-kDa protein, and 11-kDa protein). Splicing at the second 5' donor site (D2 site) of the B19V pre-mRNA is essential for the expression of VP2 and the 11-kDa protein. Read More

    History of parvovirus B19 infection is associated with silent cerebral infarcts.
    Pediatr Blood Cancer 2018 Jan 17;65(1). Epub 2017 Aug 17.
    Department of Medicine and Pediatrics, Vanderbilt-Meharry Sickle Cell Center of Excellence, Vanderbilt University Medical Center, Nashville, Tennessee.
    Background: The relationship between silent cerebral infarcts (SCIs) and history of parvovirus B19 (B19V) has not been systematically evaluated. As an ancillary study from the Silent Cerebral Infarct Trial (SIT) (NCT00072761), we tested the hypothesis that a history of B19V infection is associated with an increased prevalence of SCIs in children with sickle cell anemia.

    Procedure: We used a retrospective cross-sectional cohort study design; each participant underwent a brain magnetic resonance imaging (MRI) scan and medical record review for prior B19V infection (n = 958). Read More

    Immunohistochemical Demonstration of Parvovirus B19 Viral Protein 2 in Periflexural Exanthema in an Adult, Supporting Antibody-Dependent Enhancement as Means of Endothelial Uptake of the Virus.
    Am J Dermatopathol 2018 Feb;40(2):e19-e24
    Dermatology, and.
    Human parvovirus B19 (B19V) causes a number of skin exanthemas and has been related to both cutaneous and systemic diseases. Tropism of the virus for the rapidly proliferating erythroid progenitor cells in the bone marrow and fetal liver explains the pathogenesis of anemia and fetal hydrops. The cutaneous lesions of erythema infectiosum and other B19V-related exanthemas have been attributed to the deposition of immune complexes in the skin. Read More

    The magnitude and correlates of Parvovirus B19 infection among pregnant women attending antenatal clinics in Mwanza, Tanzania.
    BMC Pregnancy Childbirth 2017 Jun 7;17(1):176. Epub 2017 Jun 7.
    Department of Microbiology and Immunology, Weill Bugando School of Medicine, P.O.Box 1464, Mwanza, Tanzania.
    Background: Human parvovirus B19 (B19) infection has been associated with congenital infection which may result into a number of the adverse pregnancy outcomes. The epidemiology and the magnitude of B19 infections among pregnant women have been poorly studied in developing countries. This study was done to establish preliminary information about the magnitude of B19 among pregnant women attending antenatal clinics in the city of Mwanza, Tanzania. Read More

    A Case Report of Parvovirus B19 Infection in a Renal Allograft.
    Int J Surg Pathol 2017 Oct 2;25(7):648-651. Epub 2017 Jun 2.
    1 University of Illinois at Chicago Hospital and Health Sciences System, Chicago, IL, USA.
    Parvovirus B19 infection is undiagnosed in recipients undergoing solid organ transplantation. It is usually responsible for unexplained acute and chronic red blood cell aplasia that does not respond to erythropoietin therapy. Cases of parvovirus B19 infection associated with pancytopenia, solid organ dysfunction, and allograft rejection have been described in the literature. Read More

    Saccharomyces cerevisiae-derived virus-like particle parvovirus B19 vaccine elicits binding and neutralizing antibodies in a mouse model for sickle cell disease.
    Vaccine 2017 06 26;35(29):3615-3620. Epub 2017 May 26.
    Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN, United States; Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN, United States. Electronic address:
    Parvovirus B19 infections are typically mild in healthy individuals, but can be life threatening in individuals with sickle cell disease (SCD). A Saccharomyces cerevisiae-derived B19 VLP vaccine, now in pre-clinical development, is immunogenic in wild type mice when administered with the adjuvant MF59. Because SCD alters the immune response, we evaluated the efficacy of this vaccine in a mouse model for SCD. Read More

    Severe Aplastic Anemia following Parvovirus B19-Associated Acute Hepatitis.
    Case Reports Hepatol 2017 20;2017:1359486. Epub 2017 Apr 20.
    Third Department of Internal Medicine, Nara Medical University, Kashihara, Nara, Japan.
    Human parvovirus (HPV) B19 is linked to a variety of clinical manifestations, such as erythema infectiosum, nonimmune hydrops fetalis, and transient aplastic anemia. Although a few cases have shown HPVB19 infection as a possible causative agent for hepatitis-associated aplastic anemia (HAAA) in immunocompetent patients, most reported cases of HAAA following transient hepatitis did not have delayed remission. Here we report a rare case of severe aplastic anemia following acute hepatitis with prolonged jaundice due to HPVB19 infection in a previously healthy young male. Read More

    Genotype 1 of human parvovirus B19 in clinical cases.
    Rev Assoc Med Bras (1992) 2017 Mar;63(3):224-228
    PhD, Scientific Researcher, Núcleo de Doenças Respiratórias, Instituto Adolfo Lutz, São Paulo, SP, Brazil.
    Introduction:: Virus surveillance strategies and genetic characterization of human parvovirus B19 (B19V) are important tools for regional and global control of viral outbreak. In São Paulo, Brazil, we performed a study of B19V by monitoring the spread of this virus, which is an infectious agent and could be mistakenly reported as a rash and other types of infection.

    Method:: Serum samples were subjected to enzyme immunoassay, real time polymerase chain reaction, and sequencing. Read More

    Human parvovirus B19 nosocomial outbreak in healthcare personnel in a paediatric ward at a national tertiary referral centre in Thailand.
    J Hosp Infect 2017 Jun 18;96(2):163-167. Epub 2017 Mar 18.
    Division of Infectious Diseases, Department of Paediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. Electronic address:
    Background: Nosocomial outbreaks of parvovirus B19 (pB19) have been reported, but they rarely occur among healthcare personnel (HCP). Susceptibility among pregnant HCP was the major concern.

    Methods: An outbreak of pB19 among HCP is described in a paediatric ward with a cross-sectional serologic study in all HCP and patients exposed to the outbreak. Read More

    Does parvovirus infection have a role in systemic lupus erythematosus?
    Immunol Res 2017 04;65(2):447-453
    Department of Medicine E, Meir Medical Center, 44261, Kfar Saba, Israel.
    We sought to evaluate a possible link between parvovirus B19 infection and the clinical and laboratory expression of systemic lupus erythematosus (SLE). SLE patients were examined to evaluate their clinical status and disease activity. A complete Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) score was obtained for each patient. Read More

    Molecular diversity of human parvovirus B19 during two outbreaks of erythema infectiosum in Brazil.
    Braz J Infect Dis 2017 Jan - Feb;21(1):102-106. Epub 2016 Nov 30.
    Universidade Federal Fluminense, Faculdade de Medicina, Programa de Pós Graduação em Ciências Médicas, Niterói, RJ, Brazil; Universidade Federal Fluminense, Faculdade de Medicina, Disciplina de Doenças Infecciosas e Parasitárias, Niterói, RJ, Brazil.
    This study was conducted to provide information on the genetic diversity of human parvovirus B19 (B19V) circulating in the municipality of Niterói, Rio de Janeiro, Southeast Brazil during 1996-2006, a period with two distinct outbreaks of B19V infection: 1999-2000 and 2004-2005. A total of 27 sera from patients with erythema infectiosum and five sera from HIV-infected patients that tested positive for B19V DNA during the study period were analyzed. To genotype B19V strains, a semi-nested PCR for partial amplification of the capsid gene was performed and sequence analysis revealed that 31 sequences belonged to subgenotype 1a (G1a) of the main genotype 1 and one sequence was characterized as subgenotype 3b (G3b). Read More

    Parvovirus B19 infection presenting concurrently as papular-purpuric gloves-and-socks syndrome and bathing-trunk eruption.
    Clin Exp Dermatol 2017 Jan 30;42(1):58-60. Epub 2016 Nov 30.
    Dermatology Service, Fundación Jiménez Díaz, Madrid, Spain.
    Parvovirus B19 infection can cause a wide range of cutaneous manifestations, including papular-purpuric gloves-and-socks syndrome (PPGSS) and petechial bathing trunk eruption. We report a case of an immunocompetent woman with a primary parvovirus B19 infection presenting as concurrent PPGSS and petechial bathing trunk eruption. Parvovirus B19 seroconversion was confirmed several days after the onset of the clinical manifestations. Read More

    Pure red cell aplasia.
    Blood 2016 11;128(21):2504-2509
    Office of the Dean, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN.
    Pure red cell aplasia (PRCA) is a syndrome defined by a normocytic normochromic anemia with severe reticulocytopenia and marked reduction or absence of erythroid precursors from the bone marrow. Diamond-Blackfan anemia is a congenital form of PRCA. Acquired PRCA may be either a primary disorder or secondary to some other disorder or agent. Read More

    DNA Binding and Cleavage by the Human Parvovirus B19 NS1 Nuclease Domain.
    Biochemistry 2016 Nov 17;55(47):6577-6593. Epub 2016 Nov 17.
    Department of Chemistry and Biochemistry, University of Arizona , Tucson, Arizona 85721, United States.
    Infection with human parvovirus B19 (B19V) has been associated with a myriad of illnesses, including erythema infectiosum (Fifth disease), hydrops fetalis, arthropathy, hepatitis, and cardiomyopathy, and also possibly the triggering of any number of different autoimmune diseases. B19V NS1 is a multidomain protein that plays a critical role in viral replication, with predicted nuclease, helicase, and gene transactivation activities. Herein, we investigate the biochemical activities of the nuclease domain (residues 2-176) of B19V NS1 (NS1-nuc) in sequence-specific DNA binding of the viral origin of replication sequences, as well as those of promoter sequences, including the viral p6 and the human p21, TNFα, and IL-6 promoters previously identified in NS1-dependent transcriptional transactivation. Read More

    [Prevalence of Parvovirus B19 Infection in Chinese Xiamen Area Blood Donors].
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 2016 Oct;24(5):1572-1576
    Xiamen Blood Center, Xiamen 361004, Fujian Province, China. E-mail:
    Objective: To estimate the prevalence of parvovirus B19 infection in Chinese Xiamen area blood donors.

    Methods: Blood samples from blood donors were tested for detection of parvovirus B19 DNA and antibody. The direct sequencing and genetype analysis of B19 DNA positive samples were performed. Read More

    Not the Usual Viral Suspects: Parvovirus B19, West Nile Virus, and Human T-Cell Lymphotrophic Virus Infections After Kidney Transplantation.
    Semin Nephrol 2016 09;36(5):428-434
    Division of Infectious Diseases and the William J von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN. Electronic address:
    Kidney transplant recipients are at increased risk of developing clinical disease due to uncommon opportunistic viral pathogens. Refractory anemia is classically associated with parvovirus B19 infection. West Nile virus has the propensity to cause fever and neurologic symptoms, while spastic paresis and lymphoma can be triggered by human T cell lymphotrophic virus. Read More

    The VP1u Receptor Restricts Parvovirus B19 Uptake to Permissive Erythroid Cells.
    Viruses 2016 Sep 28;8(10). Epub 2016 Sep 28.
    Department of Chemistry and Biochemistry, University of Bern, Bern 3012, Switzerland.
    Parvovirus B19 (B19V) is a small non-enveloped virus and known as the causative agent for the mild childhood disease . B19V has an extraordinary narrow tissue tropism, showing only productive infection in erythroid precursor cells in the bone marrow. We recently found that the viral protein 1 unique region (VP1u) contains an N-terminal receptor-binding domain (RBD), which mediates the uptake of the virus into cells of the erythroid lineage. Read More

    Virome characterisation from Guthrie cards in children who later developed acute lymphoblastic leukaemia.
    Br J Cancer 2016 10 23;115(8):1008-1014. Epub 2016 Aug 23.
    Department of Clinical Science, Intervention and Technology, CLINTEC, Karolinska Institutet, S-141 86 Stockholm, Sweden.
    Background: Some childhood acute lymphoblastic leukaemias (ALL) can be traced back to a prenatal origin, where a virus infection could be involved in the first pre-leukaemic clone development. The DNA virome of 95 children who later developed ALL was characterised from neonatal blood spots (NBS) using unbiased next-generation sequencing (NGS) and compared with the virome of 95 non-ALL controls.

    Methods: DNA was individually extracted from the ALL-patients and controls, pooled, randomly amplified and sequenced using the Illumina MiSeq Sequencing System. Read More

    Diagnostic and prognostic value of molecular and serological investigation of human parvovirus B19 infection during pregnancy.
    New Microbiol 2016 Jul 10;39(3):181-185. Epub 2016 Jun 10.
    Molecular Virology Unit, Microbiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
    To define diagnostic and prognostic markers of parvovirus B19 (B19V) fetal infection, two groups were investigated: 1) pregnant women with specific symptoms or contacts with symptomatic households (n=37); 2) mothers with pathological ultrasound findings and the relevant fetus at the time of prenatal diagnosis (n=16). In the first group, diagnosis of B19V infection was achieved using IgM detection in 29/37 (78.3%) of patients, while B19V DNA was detected in 36/37 (97. Read More

    [Seroprevalence of human parvovirus B19 in children with fever and rash in the North of Tunisia].
    Bull Soc Pathol Exot 2016 Aug 7;109(3):165-71. Epub 2016 Jul 7.
    Unité de recherche UR12ES01, faculté de médecine de Tunis, université de Tunis El-Manar, Tunis, Tunisie.
    The aim of the study is to evaluate the prevalence of specific antibodies anti-human parvovirus B19 (PVB19) immunoglobulin M (IgM) and IgG in children with fever and rash. This study involved 257 children aged from 7 months to 15 years with febrile rash unrelated to measles and rubella (seronegative for IgM). The sera were examined by immunoenzymatic assay. Read More

    Splenic infarcts as a rare manifestation of parvovirus B19 infection.
    IDCases 2016 6;4:62-4. Epub 2016 May 6.
    First Department of Internal Medicine, Tzaneio General Hospital, Afentouli & Zanni Str., Piraeus 18536, Greece.
    Introduction: Human parvovirus B19 is a DNA virus most known for causing erythema infectiosum in children, and polyarthropathy or transient aplastic crisis in adults. However, various unusual clinical manifestations have also been reported in association with it. We describe a young patient who presented with splenic infarcts as a rare complication of B19 infection. Read More

    Seroprevalence of erythrovirus B19 in Saudi pregnant women.
    J Family Community Med 2016 May-Aug;23(2):105-8
    Department of Medical Microbiology, Faculty of Medicine, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia.
    Background: Erythrovirus B19 infection is associated with clinical symptoms that range from mild to severe. The common clinical presentation of B19 virus (B19V) infection is erythema infectiosum, arthropathy, aplastic crisis, and fetal infection. Infection in seronegative pregnant women can lead to fetal hydrops. Read More

    A False Positive Dengue Fever Rapid Diagnostic Test Result in a Case of Acute Parvovirus B19 Infection.
    Intern Med 2016 15;55(10):1379-82. Epub 2016 May 15.
    Department of Emergency Center, Toyama Prefectural Central Hospital, Japan.
    An outbreak of dengue fever occurred in Japan in August 2014. We herein report the case of a 63-year-old man who presented with a persistent fever in September 2014. Acute parvovirus B19 infection led to a false positive finding of dengue fever on a rapid diagnostic test (Panbio Dengue Duo Cassette(TM)). Read More

    Betaferon in chronic viral cardiomyopathy (BICC) trial: Effects of interferon-β treatment in patients with chronic viral cardiomyopathy.
    Clin Res Cardiol 2016 Sep 25;105(9):763-73. Epub 2016 Apr 25.
    Department of Cardiology, Campus Benjamin Franklin, Charite-Universitätsmedizin Berlin, Berlin, Germany.
    Background: Chronic viral infections of the heart are considered one antecedent event leading to progressive dysfunction of the myocardium, often with an impaired prognosis due to a virus- or immune-mediated myocardial injury. Symptomatic treatment does not influence the viral cause of heart failure, and the effect of antiviral treatment has not been determined, yet.

    Methods And Results: In this phase II study 143 patients with symptoms of heart failure and biopsy-based confirmation of the enterovirus (EV), adenovirus, and/or parvovirus B19 genomes in their myocardial tissue were randomly assigned to double-blind treatment, and received either placebo (n = 48) or 4 × 10(6) (n = 49) and 8 × 10(6) IU (n = 46) interferon beta-1b (IFN-β-1b) for 24 weeks, in addition to standard heart failure treatment. Read More

    The Receptor-Binding Domain in the VP1u Region of Parvovirus B19.
    Viruses 2016 Feb 24;8(3):61. Epub 2016 Feb 24.
    Department of Chemistry and Biochemistry, University of Bern, Bern 3012, Switzerland.
    Parvovirus B19 (B19V) is known as the human pathogen causing the mild childhood disease erythema infectiosum. B19V shows an extraordinary narrow tissue tropism for erythroid progenitor cells in the bone marrow, which is determined by a highly restricted uptake. We have previously shown that the specific internalization is mediated by the interaction of the viral protein 1 unique region (VP1u) with a yet unknown cellular receptor. Read More

    No evidence of persistent parvovirus B19 viremia among Iranian patients with HIV after a 1-year follow-up.
    Arch Virol 2016 May 10;161(5):1183-7. Epub 2016 Feb 10.
    Clinical Research Department, Pasteur Institute of Iran, No 69, Pasteur Ave., Tehran, 13164, Iran.
    Recent studies have demonstrated that, in common with other latent viruses, parvovirus B19 infection can be controlled by the host immune response but may persist in some places such as the bone marrow. Persistent B19 infection has been found in both immunocompetent and immunocompromised individuals, such as patients infected with human immunodeficiency virus (HIV). However, there is limited data regarding long-term B19 viremia in HIV patients. Read More

    Insights into epidemiology of human parvovirus B19 and detection of an unusual genotype 2 variant, Bulgaria, 2004 to 2013.
    Euro Surveill 2016 ;21(4)
    National Center of Infectious and Parasitic Diseases, Department Virology, National Reference Laboratory of Measles, Mumps and Rubella, Sofia, Bulgaria.
    The present study aimed to determine the role of human parvovirus В19 (B19V) as an aetiological agent in measles and rubella negative fever/rash patients from Bulgaria between 2004 and 2013. A total of 1,266 sera from all over the country were tested for B19V IgM antibodies and all positives were further investigated by polymerase chain reaction (PCR). Overall, 280 sera (22%) were B19V IgM positive and 227 of these (81%) were also PCR positive. Read More

    Outbreak of parvovirus B19 infection among anesthesiology and surgical fellows.
    Am J Infect Control 2016 Sep 29;44(9):1069-70. Epub 2016 Jan 29.
    Coordinación de Epidemiología Hospitalaria, Hospital Universitario Dr José Eleuterio González, Universidad Autónoma de Nuevo León, Monterrey, Mexico. Electronic address:
    A human parvovirus B19 outbreak was detected in personnel assigned to a surgical area (anesthesiology fellows and an otorhinolaryngology fellow) in a university hospital. The attack rate between susceptible members was higher than previous reports. Diagnosis was determined by polymerase chain reaction for human parvovirus B19 in serum of 1 subject and immunoglobulin M/immunoglobulin G antibody titer in the remaining subjects. Read More

    Update of the human parvovirus B19 biology.
    Transfus Clin Biol 2016 Feb 6;23(1):5-12. Epub 2016 Jan 6.
    Pôle biologie-pathologie-physiologie, CHU Saint-Louis, AP-HP, 75010 Paris, France. Electronic address:
    Since its discovery, the human parvovirus B19 (B19V) has been associated with many clinical situations in addition to the prototype clinical manifestations, i.e. erythema infectiosum and erythroblastopenia crisis. Read More

    Femoral Agminated Petechiae Associated with Acute Parvovirus B19 Infection.
    Pediatr Infect Dis J 2016 Feb;35(2):228-9
    Department of Pediatrics Japanese Red Cross Wakayama Medical Center Wakayama, Japan Department of Pediatrics School of Medicine Institute of Medical Pharmaceutical and Health Sciences Kanazawa University Ishikawa, Japan Department of Pediatrics Japanese Red Cross Wakayama Medical Center Wakayama, Japan.

    Cutaneous infectious diseases: Kids are not just little people.
    Clin Dermatol 2015 Nov-Dec;33(6):657-71. Epub 2015 Sep 14.
    Department of Dermatology, University of Connecticut Health Sciences, 21 South Road, Farmington, CT, 06032. Electronic address:
    The changes in immune response that occur with age play a significant role in disease presentation and patient management. Evolution of the innate and adaptive immune systems throughout life, influenced partly by hormonal changes associated with puberty, plays a role in the differences between pediatric and adult response to disease. We review a series of manifestations of dermatologic infectious diseases spanning bacterial, viral, and fungal origins that can be seen in both pediatric and adult age groups and highlight similarities and differences in presentation and disease course. Read More

    Focal seizure associated with human parvovirus B19 infection in a non-encephalopathic child.
    World J Pediatr 2016 Feb 18;12(1):118-20. Epub 2015 Dec 18.
    Division of Child Neurology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
    Background: The incidence of acute symptomatic (at the time of documented brain insult) seizures and single unprovoked seizures are 29-39 and 23-61 per 100 000 per year, respectively. After stabilization of the patient, finding the etiology of the seizure is of paramount importance. A careful history and physical examination may allow a diagnosis without need for further evaluation. Read More

    The role of parvovirus B19 in the pathogenesis of autoimmunity and autoimmune disease.
    J Clin Pathol 2016 Apr 7;69(4):279-91. Epub 2015 Dec 7.
    Human parvovirus B19 is a single-stranded DNA virus which preferentially targets the erythroblasts in the bone marrow. B19 infection commonly causes erythema infectiosum, arthralgia, fetal death, transient aplastic crisis in patients with shortened red cell survival, and persistent infection in people who are immunocompromised. Less common clinical manifestations include atypical skin rashes, neurological syndromes, cardiac syndromes, and various cytopenias. Read More

    Viral Skin Diseases.
    Prim Care 2015 Dec;42(4):517-67
    Center for Dermatology, Laser, and Cosmetic Surgery, Psoriasis Infusion and Treatment Center, 9892 Bustleton Avenue, Suite 204, Philadelphia, PA 19115, USA.
    In the vast world of skin diseases, viral skin disorders account for a significant percentage. Most viral skin diseases present with an exanthem (skin rash) and, oftentimes, an accompanying enanthem (lesions involving the mucosal membrane). In this article, the various viral skin diseases are explored, including viral childhood exanthems (measles, rubella, erythema infectiosum, and roseola), herpes viruses (herpes simplex virus, varicella zoster virus, Kaposi sarcoma herpes virus, viral zoonotic infections [orf, monkeypox, ebola, smallpox]), and several other viral skin diseases, such as human papilloma virus, hand, foot, and mouth disease, molluscum contagiosum, and Gianotti-Crosti syndrome. Read More

    Confirmation of etiology in fetal hydrops by sonographic evaluation of fluid allocation patterns.
    Eur J Obstet Gynecol Reprod Biol 2015 Dec 19;195:128-32. Epub 2015 Oct 19.
    Amedes Praxis für Endokrinologie, Kinderwunsch und Pränatalmedizin, Hamburg, Germany.
    Objective: To evaluate patterns of fluid allocations in different etiologies of hydrops fetalis.

    Study Design: This report is a retrospective cohort study on 20,395 fetal sonographic evaluations in a single tertiary center from 2000 to 2014. Special emphasis was placed on the exact description of the distinct fluid allocation sites in each fetus. Read More

    Parvovirus B19-Associated Microvesicular Eruption.
    Pediatr Dermatol 2015 Nov-Dec;32(6):e303-4. Epub 2015 Oct 8.
    Department of Dermatology, Hospital Clinico Universitario, Valencia, Spain.
    We report on a 3-year-old girl with a microvesicular generalized rash in whom primary infection by parvovirus B19 was demonstrated by seroconversion. To our knowledge, this is the first instance of an eruption arising from parvovirus B19 with this peculiar clinical pattern. Read More

    Parvovirus B19-induced acute bilateral carpal tunnel syndrome in twin girls.
    Acta Orthop Traumatol Turc 2015 ;49(5):568-70
    Başkent University Faculty of Medicine, Department of Neurology, Konya, Turkey.
    We describe 2 cases of 6-year-old twin girls presenting with acute carpal tunnel syndrome (CTS) associated with human parvovirus B19 (HPV-B19) infection, as evidenced by serological data and detection of HPV-B19 DNA in blood with use of polymerase chain reaction (PCR). To our knowledge, this is the first time that HPV-B19 infection has been suggested as the causal agent of simultaneous acute bilateral CTS in twins, thus presenting the possibility that similar immunologic responses can be observed in twins during viral infections. Read More

    1 OF 25