Immunohistochemical Demonstration of Parvovirus B19 Viral Protein 2 in Periflexural Exanthema in an Adult, Supporting Antibody-Dependent Enhancement as Means of Endothelial Uptake of the Virus.
Am J Dermatopathol 2017 Jul 6. Epub 2017 Jul 6.
Departments of *Pathology, †Dermatology, and ‡Internal Medicine, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain; and §Dermatopathologie Friedrichshafen, Friedrichshafen, Germany.
Human parvovirus B19 (B19V) causes a number of skin exanthemas and has been related to both cutaneous and systemic diseases. Tropism of the virus for the rapidly proliferating erythroid progenitor cells in the bone marrow and fetal liver explains the pathogenesis of anemia and fetal hydrops. The cutaneous lesions of erythema infectiosum and other B19V-related exanthemas have been attributed to the deposition of immune complexes in the skin. Read More