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    373 results match your criteria Erythema Elevatum Diutinum

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    Leukocytoclastic vasculitis associated with endocarditis in a patient with transposition of the great arteries and mechanical valve replacement.
    Cardiovasc Pathol 2017 Mar - Apr;27:68-70. Epub 2017 Jan 24.
    Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.
    Immunological vascular phenomena can be the initial manifestation of bacterial infection and endocarditis. Here, we report a rare case of leukocytoclastic vasculitis without immune complexes or cryoglobulinemia in a patient with infective endocarditis, congenital heart disease, and a prior mechanical valve replacement. The patient completely recovered following antibiotic therapy, and skin lesions disappeared without immune suppression, which suggested infection-mediated vasculitis. Read More

    Leukocytoclastic Vasculitis Secondary to Pyridostigmine (Mestinon): Report of a Possible First Case.
    Perm J 2017 18;21. Epub 2016 Nov 18.
    Consultant in Medicine at The Dunedin Hospital; an Honorary Clinical Senior Lecturer at the University of Otago School of Medicine in Dunedin, New Zealand; Clinical Assistant Professor of Medicine at Stanford University School of Medicine; and a Hospitalist at the Santa Clara Medical Center in CA.
    Introduction: Pyridostigmine is an acetylcholinesterase inhibitor commonly used in the treatment of myasthenia gravis. We describe a patient who developed a rash after recently being started on pyridostigmine and give a general review of leukocytoclastic vasculitis.

    Case Presentation: A 91-year-old man was diagnosed with ocular myasthenia gravis. Read More

    Chronic Localized Fibrosing Leukocytoclastic Vasculitis Associated With Lymphedema, Intralymphatic and Intravascular Lymphocytosis, and Chronic Myelogenous Leukemia: A Case Report of Unilateral Erythema Elevatum Diutinum.
    Am J Dermatopathol 2016 Dec 7. Epub 2016 Dec 7.
    *Department of Pathology, Albany Medical College, Albany, NY; and †Departamento de Dermatología, Area de Dermatopatología, Hospital Luis Vernaza, Guayaquil, Ecuador.
    One of the pathogenic causes of cutaneous inflammatory pseudotumors is chronic localized fibrosing leukocytoclastic vasculitis (CLFLCV), a vasculitic reaction pattern seen in granuloma faciale (GF), a localized vasculitis, and erythema elevatum diutinum (EED), a generalized vasculitis. Patients with myelodysplastic syndromes (MDSs) are at risk for a diverse spectrum of cutaneous neutrophilic dermatoses such as EED. Herein, we report a 74-year-old man who presented with a large ulcerative, fungating tumor affecting the right flexor ankle caused by CLFLCV. Read More

    Leukocytoclastic vasculitis associated with hairy cell leukemia at diagnosis: a case report and review of the literature.
    Tumori 2016 Nov 11;102(Suppl. 2). Epub 2016 Nov 11.
    Institute of Hematology L. and A. Seràgnoli, University of Bologna, Bologna - Italy.
    Background: Autoimmune manifestations may occur in patients with hairy cell leukemia (HCL), and some rare cases of polyarteritis nodosa and leukocytoclastic vasculitis have been reported. However, data regarding the treatment of these cutaneous manifestations are lacking, given the rarity of the concomitance of HCL and vasculitic syndromes.

    Case Presentation: We present a 37-year-old man with paraneoplastic leukocytoclastic vasculitis complicating newly diagnosed HCL. Read More

    Approach to cutaneous vasculitides with special emphasis on small vessel vasculitis: histopathology and direct immunofluorescence.
    Curr Opin Rheumatol 2017 Jan;29(1):39-44
    Department of Pathology, Acıbadem University, Istanbul, Turkey.
    Purpose Of Review: The present review will focus on recent publications in cutaneous vasculitides.

    Recent Findings: Some histopathological and clinical features, such as papillary dermal edema, perivascular C3 deposition, clinically evident edema, and lesions above the waist, may point out renal or gastrointestinal involvement in Henoch-Schönlein purpura (HSP). HSP associated with familial Mediterranean fever differs from typical isolated HSP by showing no deposits of IgA, much younger age, and location of the lesions on the face or the trunk. Read More

    Erythema elevatum diutinum in association with IgA monoclonal gammopathy: A rare case report.
    Indian Dermatol Online J 2016 Jul-Aug;7(4):300-3
    Deparment of Dermatology Venereology and Leprosy, Andhra Medical College, Visakhapatnam, Andhra Pradesh, India.
    Erythema elevatum diutinum (EED) is a rare form of vasculitis characterized clinically by red-violet brown papules, plaques, and nodules mainly involving the extensor surfaces; histologically by leukocytoclastic vasculitis in early lesions, and fibrosis and cholesterolosis in late lesions. EED has been associated with many systemic disorders including infections, autoimmune disorders, and both benign and malignant hematological disorders. As it is a rare form of vasculitis and only 250 cases reported till date, we report a case of EED in association with IgA monoclonal gammopathy with partial response to dapsone treatment. Read More

    Etiologies and prognostic factors of leukocytoclastic vasculitis with skin involvement: A retrospective study in 112 patients.
    Medicine (Baltimore) 2016 Jul;95(28):e4238
    aService de médecine interne et immunologie clinique bService de médecine interne et maladies systémiques cService de dermatologie dLaboratoire d'anatomopathologie eService de pneumologie fService de maladies infectieuses, CHU François Mitterrand, Dijon, France.
    In this study, outcomes of patients with leukocytoclastic vasculitis (LCV) were analyzed focusing on clinical, histopathology and laboratory findings, relapses, and survival.Data from patients with cutaneous vasculitis diagnosed between January 1, 2000, and December 31, 2010, at Dijon University Hospital (France) were retrospectively reviewed. LCV was defined as perivascular neutrophilic infiltrate, endothelial cell nuclear swelling, extravasation of red blood cells, and/or fibrin deposition in vessels. Read More

    Erythema elevatum diutinum in acquired immune deficiency syndrome: Can it be an immune reconstitution inflammatory syndrome?
    Indian J Sex Transm Dis 2016 Jan-Jun;37(1):81-4
    Department of Skin-VD, SSG Hospital, Vadodara, Gujarat, India.
    A 47-year-old male with acquired immune deficiency syndrome (AIDS) presented with multiple hyperpigmented papules and nodules on both ankles, dorsum of bilateral feet and soles. It was associated with mild itching and pain. The patient was diagnosed with human immunodeficiency virus (HIV) in 2007. Read More

    IgG4-Related Sialoadenitis with a Skin Lesion and Multiple Mononeuropathies Suggesting Coexistent Cryoglobulinemic Vasculitis.
    Intern Med 2016 15;55(10):1355-61. Epub 2016 May 15.
    Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Japan.
    A 68-year-old man was admitted because of weakness of the left leg, dysesthesiae of the extremities and bilateral lower extremity purpura. A neurological examination showed mononeuritis multiplex with laboratory evidence of hypocomplementemia, cryoglobulinemia and leukocytoclastic vasculitis in the biopsy of a skin specimen. The patient also exhibited bilateral submandibular gland swelling, elevated serum IgG4 levels and infiltration of a large number of IgG4-positive plasma cells in the submandibular glands. Read More

    Granuloma Faciale and Erythema Elevatum Diutinum in Relation to Immunoglobulin G4-Related Disease: An Appraisal of 32 Cases.
    Am J Clin Pathol 2016 Mar 2;145(3):401-6. Epub 2016 Mar 2.
    Departments of Dermatology, Pathology and Laboratory Medicine, Mayo Clinic College of Medicine, Rochester, MN.
    Objectives: To elucidate whether granuloma faciale (GF) and erythema elevatum diutinum (EED), two inflammatory skin dermatoses, meet the consensus histopathologic diagnostic criteria for immunoglobulin G4-related disease (IgG4-RD).

    Methods: With institutional review board approval, we assessed the clinical, microscopic, and immunophenotypic features of skin specimens of patients with GF and EED. We compared these findings with previously published consensus diagnostic criteria for IgG4-RD. Read More

    Early Onset Dapsone-induced Photosensitive Dermatitis: A Rare Side Effect of a Common Drug.
    Indian J Lepr 2015 Jul-Sep;87(3):161-4
    Dapsone, a potent anti-inflammatory compound, is mainly used in the treatment of leprosy, dermatitis herpetiformis, erythema elevatum diutinum and other dermatoses. Cutaneous adverse reactions range from acneiform eruptions to toxic epidermal necrolysis. A 30-year-old, married women who was treated with paucibacillary multi drug therapy, developed itchy skin lesions over the both forearms, 'V ' area of the neck and upper back after one week of the drug administration which worsened on exposure to sunlights. Read More

    Neutrophilic Dermatoses in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A French Multicenter Study of 17 Cases and Literature Review.
    Medicine (Baltimore) 2016 Mar;95(11):e2957
    From the Department of Internal Medicine, Caen University Hospital, Caen (HDB, NMS, BB, AA); Department of Internal Medicine, Brest University Hospital (CDM); Department of Internal Medicine, Nantes University Hospital (AN); Department of Internal Medicine, Assistance Publique Hôpitaux de Paris, Saint-Louis Hospital, Paris, France (MDM); Department of Rheumatology, Assistance Publique Hôpitaux de Paris, Bichat University Hospital, Paris, France (OM); Department of Internal Medicine, Lille University Hospital, France (DL); Mount Sinai Hospital, University Health Network, and University of Toronto, Toronto, Ontario, Canada (CP); and Department of Internal Medicine, Assistancec Publique Hôpitaux de Paris, Cochin Hospital, Paris, France (LG, XP).
    A few reports suggest combination of ANCA-associated vasculitis (AAV) and neutrophilic dermatoses (ND). We aimed to describe the main characteristics of patients presenting with both AAV and ND in a French cohort and through a systematic literature review, and to discuss the possible common pathogenic process involved. We conducted a retrospective study of patients with both conditions. Read More

    Hidradenitis suppurativa (HS): An unrecognized paradoxical effect of biologic agents (BA) used in chronic inflammatory diseases.
    J Am Acad Dermatol 2016 Jun 8;74(6):1153-9. Epub 2016 Mar 8.
    Dermatology Department, Hôpital Edouard Herriot, Université Claude Bernard Lyon I, Lyon, France.
    Background: Paradoxical hidradenitis suppurativa (HS) induced by biologic agents (BA) is scarcely reported.

    Objective: We sought to describe the clinical characteristics and outcome of patients developing paradoxical HS under BA.

    Methods: This was a multicenter nationwide retrospective study asking physicians to report all cases of HS, confirmed by a dermatologist, occurring during treatment of an inflammatory disease by a BA. Read More

    Leukocytoclastic vasculitis associated with perforated diverticular disease.
    BMJ Case Rep 2016 Jan 20;2016. Epub 2016 Jan 20.
    Department of Surgery, Medway Maritime Hospital, Gillingham, Kent, UK.
    Leukocytoclastic vasculitis (LV) is a small vessel vasculitis associated with infections, connective tissue disease, malignancies and, rarely, gastrointestinal conditions. An association between LV and acute diverticulitis has not previously been reported. LV may be localised to the skin as a purpuric rash or might manifest with systemic involvement, such as of the joints, gastrointestinal tract or kidneys. Read More

    Henoch Schonlein purpura associated with bee sting: case report.
    Medwave 2015 Oct 30;15(9):e6297. Epub 2015 Oct 30.
    Departamento de Fisiología, Facultad de Medicina, Universidad Nacional de Trujillo, Trujillo, Perú
    Henoch Schonlein purpura (HSP) is a common childhood vasculitis, characterized by a non-thrombocytopenic palpable purpura and systemic features. It can be triggered by conditions like infections and insect bites. We present the case of a six-year-old girl with palpable maculopapular lesions on the lower limbs, itching, mild pain, swelling of feet, limitation of limb mobility, and a history of bee sting. Read More

    Acute hemorrhagic edema of young children: a prospective case series.
    Eur J Pediatr 2016 Apr 25;175(4):557-61. Epub 2015 Nov 25.
    University Children's Hospital Berne, University of Berne, Berne, Switzerland.
    Unlabelled: Acute hemorrhagic edema of young children is a rare leukocytoclastic vasculitis that has been reported exclusively in small retrospective cases series, case reports, or quizzes. Considering that retrospective experience deserves confirmation in at least one observational prospective study, we present our experience with 16 children (12 boys and 4 girls, 5-28 months of age) affected by acute hemorrhagic edema. The patients were in good general conditions and with a low-grade or even absent fever. Read More

    Erythema elevatum diutinum and hypothyroidism: coincidence or causal relationship?
    An Bras Dermatol 2015 Jul-Aug;90(4):561-3
    Universidade de Taubaté, Taubaté, SP, BR.
    Erythema elevatum diutinum is a rare chronic leukocytoclastic vasculitis of unknown etiology. It is believed to be due to deposition of immune complexes in the vessels. Clinically it is manifested as erythematous violaceous papules and nodules, isolated or confluent with hardened consistency, symmetrical, usually located on the extensor surface of the extremities, particularly over the joints. Read More

    [Cutaneous symptoms of various vasculitides].
    Hautarzt 2015 Aug;66(8):589-98
    Abteilung für Translationale Dermatoinfektiologie, Medizinische Fakultät, Universität Münster und Universitätsklinikum Münster, Röntgenstraße 21, 48149, Münster, Deutschland,
    The skin is one of the organs most frequently involved in vasculitides. Cutaneous vasculitis may present (1) part of a systemic vasculitis (e.g. Read More

    [Dermatological manifestations of monoclonal gammopathies: contribution of cutaneous histopathology].
    Ann Pathol 2015 Aug 15;35(4):281-93. Epub 2015 Jul 15.
    Département de pathologie, hôpital Henri-Mondor, Assistance publique-Hôpitaux de Paris (AP-HP), faculté de médecine, université Paris-Est-Créteil, 94010 Créteil cedex, France.
    Skin manifestations associated with monoclonal gammapathy are common and can present with various clinical and pathological aspects. They can be the first events leading to the diagnosis of monoclonal gammapathy. They may be present either as specific lesions, including lymphoplasmacytic or pure plasma cell neoplastic infiltrates and monoclonal immunoglobulin deposits, or as non-specific dermatitis, such as leukocytoclastic vasculitis, neutrophilic dermatoses, mucinoses or xanthomatosis, giving little clues for the diagnosis of the underlying disease. Read More

    Erythema elevatum diutinum coexisting with ankylosing spondylitis.
    Eur J Rheumatol 2015 Jun 31;2(2):73-75. Epub 2015 Mar 31.
    Department of Rheumatology, Çukurova University Faculty of Medicine, Adana, Turkey.
    A 43-year-old woman presented to our hospital with the complaint of a reddish-purple rash on the extensor sides of her forearms. She had been diagnosed with ankylosing spondylitis 7 years ago. On physical examination, reddish-purple nodules were detected on the pretibial areas of both legs and extensor sides of both hands and forearms. Read More

    HIV-associated large-vessel vasculopathy: a review of the current and emerging clinicopathological spectrum in vascular surgical practice.
    Cardiovasc J Afr 2015 Mar-Apr;26(2):70-81
    Department of Cardiology, University of KwaZulu-Natal, Durban, South Africa.
    An established relationship exists between human immunodeficiency virus (HIV) and the vascular system, which is characterised by clinical expressions of aneurysmal and occlusive disease that emanate from a common pathological process. The exact pathogenesis is currently unknown; attempts to implicate opportunistic pathogens have been futile. Theories converge on leucocytoclastic vasculitis with the vaso vasora as the vasculopathic epicentre. Read More

    A case of mistaken identity: unilateral erythema elevatum diutinum associated with IgA paraproteinaemia.
    Clin Exp Dermatol 2015 Oct 7;40(7):761-4. Epub 2015 Mar 7.
    Department of Dermatology, St George's Hospital, London, UK.
    We report the case of a 27-year-old woman presenting with unilateral painless nodules of the left hand following trauma. Initially diagnosed as nontuberculous mycobacterium infection and treated with prolonged courses of antibiotics with little improvement, the condition was subsequently diagnosed histologically as erythema elevatum diutinum (EED). The lesion was treated with surgical excision, and the patient remained lesion-free at the 1-year follow-up. Read More

    Chronic localized leukocytoclastic vasculitis: clinicopathological spectrum of granuloma faciale with and without extrafacial and mucosal involvement.
    G Ital Dermatol Venereol 2015 Feb 16;150(1):87-94. Epub 2015 Jan 16.
    Dermatology Unit, Department of Medical, Surgical Diagnostic and Pediatric Science, University of Pavia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy -
    Granuloma faciale (GF) is a rare cutaneous condition of unknown origin, that usually presents as one or more brown-purple papules, plaques and/or nodules, localized mostly on the face, although extrafacial lesions can also occur. Eosinophilic angiocentric fibrosis (EAF) is regarded as the mucosal counterpart of GF. Histologically, it has been described as a persistent leukocytoclastic vasculitis, with a dense polymorphous inflammatory infiltrate in the superficial and mid dermis, typically sparing the subpapillary dermis, the so called grenz zone. Read More

    Urticarial vasculitis and urticarial autoinflammatory syndromes.
    G Ital Dermatol Venereol 2015 Feb 14;150(1):41-50. Epub 2015 Jan 14.
    Department of Medico‑Surgical and Transplantation Physiopathology, Operative Unit of Dermatology,University of Milan, Italy, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy -
    Urticaria is a frequent disorder classified as acute and chronic forms, which presents with wheals that can be associated with angioedema. Several entities may manifest with urticarial skin lesions, encompassing a heterogeneous group of conditions that have to be differentiated from ordinary urticaria. This review is focused on two of these urticarial syndromes: urticarial vasculitis (UV), which represents the most important differential diagnosis with common urticaria, and autoinflammatory diseases such as cryopyrin-associated periodic syndromes (CAPS) and Schnitzler's Syndrome, both rare multisystem forms that may masquerade as common urticaria. Read More

    Acute brucellosis associated with leukocytoclastic vasculitis and splenic infarct.
    Infez Med 2014 Dec;22(4):326-30
    Department of Gastroenterology, Diyarbakir Education and Research Hospital; Department of Dermatology, Faculty of Medicine, Dicle University; Department of Dermatology, Diyarbakir Education and Research Hospital, Diyarbakir, Turkey.
    Brucellosis is globally the most prevalent multisystem infection of zoonotic origin, while it is still one of the most important public health problems in Turkey as non-pasteurised milk and dairy products are consumed. Early diagnosis is vital to prevent the possibly lethal complications caused by the disease. However, diagnosis might be delayed as the disease does not have a single and typical manifestation and presents with various symptoms of different systems. Read More

    Florid urticarial vasculitis heralding a flare up of ulcerative colitis.
    BMJ Case Rep 2014 Dec 22;2014. Epub 2014 Dec 22.
    Department of Dermatology, York Hospital, York, UK.
    A 75-year-old man with ulcerative colitis (UC) and diet controlled diabetes mellitus presented with a 3-week history of slightly itchy, red plaques on both lower limbs ascending gradually to cover the trunk and arms. One week later, he developed a flare up of his UC. Routine blood tests showed modest drop in haemoglobin (122 g/L) and C reactive protein (85 mg/L). Read More

    Nodular Erythema Elevatum Diutinum Mimicking Kaposi's Sarcoma in a Human Immunodeficiency Virus Infected Patient.
    Indian J Dermatol 2014 Nov;59(6):592-4
    Surya Skin Care and Research Center, Visakhapatnam, Andhra Pradesh, India.
    Erythema elevatum diutinum (EED) has been emerging as a specific Human Immunodeficiency Virus (HIV) associated dermatosis in recent times. It is an extremely rare chronic disease of unknown origin and part of the spectrum of leukocytoclastic vasculitis. We describe a case of EED simulating Kaposi's sarcoma in a 52-year-old HIV infected female patient with no previous opportunistic infections and CD4+ count of 164/mm(3). Read More

    [Erythema elevatum diutinum on glans penis is a rare manifestation].
    Ugeskr Laeger 2014 Oct;176(43)
    Urologisk Afdeling, Rigshospitalet, Blegdamsvej 9, 2100 København Ø.
    Erythema elevatum diutinum (EED) is a rare chronic cutaneous vasculitis, which typically manifests as symmetrical, chronic plaques or nodules on the extensor sides of the extremities, on truncus or nates. We present a case where EED-compatible plaques were located on glans penis. To our knowledge this has been reported only thrice prior to this case. Read More

    Erythema elevatum diutinum: a review of presentation and treatment.
    J Eur Acad Dermatol Venereol 2014 Dec 7;28(12):1594-602. Epub 2014 Oct 7.
    St John's Institute of Dermatology, London, UK.
    Erythema elevatum diutinum (EED) is a rare, chronic and treatable skin condition. It has many histological mimics and is often associated with a variety of underlying systemic diseases, when these are present the management and prognosis dictates the course of the EED. This review aims to highlight the differential diagnosis, clinical manifestations of EED and the possible underlying systemic disease. Read More

    Utility of immunofluorescence testing for vascular IgA in adult patients with leukocytoclastic vasculitis.
    Am J Clin Pathol 2014 Sep;142(3):370-4
    From the Department of Pathology, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA.
    Objectives: The purpose of this study was to examine the utility of immunofluorescence (IF) testing in patients with leukocytoclastic vasculitis (LCV), particularly with regard to usefulness in the diagnosis of Henoch-Schönlein purpura (HSP).

    Methods: We retrospectively analyzed the results of IF testing in 96 patients with LCV and compared results with clinical criteria and clinical impression at the time of biopsy by review of the medical record.

    Results: Sensitivity and specificity of vascular immunoglobulin A (IgA) for the diagnosis of HSP were 0. Read More

    Incidence of leukocytoclastic vasculitis, 1996 to 2010: a population-based study in Olmsted County, Minnesota.
    Mayo Clin Proc 2014 Nov 27;89(11):1515-24. Epub 2014 Jun 27.
    Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN.
    Objective: To determine the population-based incidence of leukocytoclastic vasculitis (LCV).

    Patients And Methods: This is a retrospective population-based study of all Olmsted County, Minnesota, residents with a skin biopsy-proven diagnosis of LCV from January 1, 1996, through December 31, 2010.

    Results: A total of 84 patients (mean age at diagnosis, 48. Read More

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