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Rheumatology (Oxford) 2020 Apr 15. Epub 2020 Apr 15.

Department of Dermatology, Peking University First Hospital, Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, National Clinical Research Center for Skin and Immune Disease, Beijing, China.

Indian J Dermatol 2020 Mar-Apr;65(2):164-165

Department of Dermatology and Venereology, Reina Sofía Universitary Hospital, Córdoba, Spain. E-mail:

An Bras Dermatol 2020 Mar - Apr;95(2):200-202. Epub 2020 Feb 12.

Department of General Medicine, Teaching Hospital, Universidade Federal de Pelotas, Pelotas, RS, Brazil.

Erythema elevatum diutinum is a small vessel vasculitis which is benign, rare, and chronic. It is clinically characterized by violaceous, brown, or yellowish plaques, nodules, and papules. It has been associated with autoimmune, infectious, and neoplastic processes. Read More

G Ital Dermatol Venereol 2020 Mar 4. Epub 2020 Mar 4.

Section of Dermatology, Department of Medical Sciences, University of Turin, Turin, Italy.

Open Access Maced J Med Sci 2019 Sep 30;7(18):3039-3042. Epub 2019 Aug 30.

Department of Dermatology, University of Rome "G. Marconi", Rome, Italy.

Background: Erythema elevatum diutinum (EED) belongs to the spectrum of cutaneous leukocytoclastic vasculitides. EED is a very rare dermatosis presenting with reddish to browning papules and plaques. EED may be associated with infections, hematologic and autoimmune disorders. Read More

JAAD Case Rep 2019 Dec 26;5(12):1093-1096. Epub 2019 Nov 26.

University of Utah School of Medicine, Salt Lake City, Utah.

Int J STD AIDS 2019 11 15;30(13):1337-1339. Epub 2019 Nov 15.

Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.

JAAD Case Rep 2019 Nov 28;5(11):985-987. Epub 2019 Oct 28.

Department of Dermatology University Hospitals Cleveland Medical Center, Cleveland, Ohio.

Acta Derm Venereol 2019 10 30. Epub 2019 Oct 30.

Department of Dermatology, American University of Beirut, PO Box 11-0236, Riad El Solh, Beirut, Lebanon.

Formation of neutrophil extracellular traps has been implicated in autoimmunity. However, the presence and clinical relevance of neutrophil extracellular traps in immune-complex-mediated cutaneous small and medium vessel vasculitides has not been investigated. This study retrospectively analysed 72 patients with histology-proven hypersensitivity vasculitis (n = 21), IgA vasculitis (n = 22), urticarial vasculitis (n = 22), erythema elevatum diutinum (n = 3) and polyarteritis nodosa (n = 4). Read More

Indian J Pharmacol 2019 Jul-Aug;51(4):282-283

Department of Psychiatry, JSS Medical College, JSS AHER, Mysuru, Karnataka, India.

J Cutan Pathol 2019 Aug;46(8):551-554

Skin Research Center, Shahid Beheshti University of Medical Sciences, Shohada-e Tajrish Hospital, Tehran, Iran.

Am J Hematol 2019 12 23;94(12):1433-1434. Epub 2019 Aug 23.

Division of Hematology and Oncology, Department of Internal Medicine, Loma Linda University, Loma Linda, California.

J Basic Clin Physiol Pharmacol 2019 Jul 18;30(4). Epub 2019 Jul 18.

Vardhman Mahavir Medical College and Safdarjung Hospital, Department of Pharmacology, New Delhi, India.

Clomiphene citrate is a first-line drug for the induction of ovulation in infertility cases. Leukocytoclastic vasculitis (LCV) is an extremely rare serious adverse drug reaction to clomiphene. We report here the case of a 30-year-old Indian female patient who presented with generalized petechiae and palpable purpura without fever and sparing the mucosa, temporally related to clomiphene intake and consistent with LCV histologically. Read More

Med J Aust 2019 06 24;210(11):491-491.e1. Epub 2019 May 24.

Royal North Shore Hospital, Sydney, NSW.

Am J Case Rep 2019 May 23;20:730-734. Epub 2019 May 23.

Department of Pediatrics, New York Presbyterian Brooklyn Methodist Hospital, Brooklyn, NY, USA.

BACKGROUND Leukocytoclastic vasculitis is a disease of the small vessels and is uncommon in children. In this case report, we present an adolescent case of leukocytoclastic vasculitis associated with the ingestion of colloidal silver, a naturopathic drug. This report highlights the rarity of the patient's presentation and inducing agent. Read More

Rev Esp Enferm Dig 2019 05;111(5):402-404

Unidad Enf. Inflam. Intest. Servicio de Digestivo., Hospital Universitario Central de Asturias.

Patients with inflammatory bowel disease are likely to receive immunomodulation treatment and therefore, should be properly vaccinated. Despite their proven safety, vaccines are not exempt from adverse reactions. The clinical case was a young female with ulcerative colitis under mesalazine treatment, who developed leukocytoclastic vasculitis following vaccination for pneumococci, varicella and hepatitis A. Read More

Fetal Pediatr Pathol 2019 Apr 2;38(2):121-126. Epub 2019 Jan 2.

b Department of Pathology , Tehran University of Medical Sciences , Tehran , Iran.

Objective: Henoch-Schonlein purpura (HSP) is a common vasculitis in children that can present with multi-organ involvement. The aim of this study is to investigate the correlation between direct immunofluorescence (DIF) results and the systemic involvements of the HSP in pediatric patients.

Material And Methods: Those HSP patients with leukocytoclastic vasculitis on their biopsies who also had documented immunoglobulin/complement deposition by DIF were included in our study. Read More

J Investig Allergol Clin Immunol 2018 Dec;28(6):417-418

Servicio de Enfermedades del Sistema Inmune-Alergia, Hospital Universitario Príncipe de Asturias, Departamento de Medicina y Especialidades Médicas; Universidad de Alcalá, Alcalá de Henares, Madrid, Spain.

Asian Pac J Allergy Immunol 2020 Mar;38(1):47-51

Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755-8505, Japan.

Vancomycin (VCM) has been reported to elicit adverse cutaneous drug reactions. However, VCM-associated purpuric drug eruption has not been reported yet, except leukocytoclastic vasculitis. A 16-year-old Japanese girl was admitted with a respiratory infection. Read More

J Cutan Pathol 2019 Feb 3;46(2):97-101. Epub 2018 Dec 3.

Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio.

Background: Erythema elevatum diutinum (EED) is a rare vasculitis with variable clinical presentation which diagnosis can be challenging. Herein we want to describe the clinicopathological spectrum of findings in five cases of EED.

Methods: We retrospectively analyzed five cases in a single institution collected over a period of 27 years. Read More

Hautarzt 2018 10;69(10):878

Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität München, Frauenlobstr. 9-11, 80337, München, Deutschland.

Hautarzt 2018 Oct;69(Suppl 1):31-33

Klinik und Poliklinik für Dermatologie und Allergologie der Ludwig-Maximilians-Universität München, Frauenlobstr. 9-11, 80337, München, Deutschland.

J Hand Surg Am 2019 Jun 18;44(6):522.e1-522.e5. Epub 2018 Sep 18.

Department of Orthopaedics, Louisiana State University Health Sciences Center, New Orleans, LA.

Erythema elevatum diutinum (EED) is a rare skin disease caused an Arthrus-type immunological reaction to antigen with immune complex deposition in the cutaneous microvasculature, which leads to tissue damage secondary to the effects of complement and leukocytes. It presents as brown or red cutaneous nodules, papules, or plaques, often on the extensor surfaces of the hands, knees, or elbows. Onset usually occurs in the fourth to sixth decades but possibly younger in patients with human immunodeficiency virus. Read More

JAAD Case Rep 2018 Sep 18;4(8):824-826. Epub 2018 Sep 18.

Dermatology Department, Hôtel-Dieu University Hospital, Nantes, France.

J Pediatr Endocrinol Metab 2018 Oct;31(10):1165-1168

Ghent University, Department of Pediatrics and Medical Genetics, Ghent, Belgium.

Background The association of hyperthyroidism with renal disease is very rare and the importance of timely clinical recognition cannot be overemphasized. Case presentation An 11-year-old girl presented with gastrointestinal symptoms while hypertension, edema and abdominal pain were noticed on clinical examination. Laboratory investigation revealed: hemoglobin 9. Read More

Therapie 2019 Jun 24;74(3):347-354. Epub 2018 Jul 24.

Département de pharmacologie, faculté de médecine de Sousse, université de Sousse, avenue Md Karoui, 4002 Sousse, Tunisie.

Introduction: Drug-induced vasculitis is reported in almost 10-20 % of vasculitis. Several drugs may be incriminated in their occurrence. Our study aimed to study the epidemiological, clinical, histopathological and evolutionary characteristics of drug-indced vasculitis from a series of cases and to specify the different drugs involved. Read More

Dermatol Online J 2018 05 15;24(5). Epub 2018 May 15.

Medstar Georgetown University Hospital, Washington, District of Columbia.

A 24-year-old man with untreated human immunodeficiency virus (HIV) infection consulted our outreach clinic owing to the development of numerous asymptomatic nodules on his palms and fingers. Histopathologic evaluation revealed leukocytoclastic vasculitis and prominent fibrosis with a neutrophilic infiltrate consistent with erythema elevatum diutinum (EED). We referred the patient for initiation of antiretroviral therapy and started him on dapsone. Read More

Clin Breast Cancer 2018 10 16;18(5):e755-e758. Epub 2018 Aug 16.

Medical Oncology Department, Institut de Cancérologie de l'Ouest, Centre Paul Papin, Angers, France.

Am J Gastroenterol 2018 08;113(8):1114

Department of Gastroenterology, Centro Hospitalar Vila Nova de Gaia Espinho, Vila Nova Gaia, Portugal. Department of Pathology, Centro Hospitalar Vila Nova de Gaia Espinho, Vila Nova Gaia, Portugal.

Int J Dermatol 2019 Apr 3;58(4):408-415. Epub 2018 Aug 3.

The Kimberly and Eric J. Waldman Department of Dermatology and Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Erythema elevatum diutinum (EED) is a rare cutaneous leukocytoclastic vasculitis thought to be related to increased levels of circulating antibodies. It has been shown to be associated with HIV infection, tuberculosis, as well as various autoimmune diseases. A retrospective review of all cases of EED indexed in PubMed between 1990 and 2014 was performed. Read More

Pediatr Rev 2018 Aug;39(8):418-420

Department of Pediatrics, Cohen Children's Medical Center at Northwell Health, New Hyde Park, NY.

An Bras Dermatol 2018 Jul-Aug;93(4):614-615

Service of Dermatology, Hospital Guilherme Álvaro, Centro Universitário Lusíada, Santos (SP), Brazil.

Cutis 2018 Jun;101(6):462-465

Ohio State University Medical Center, Columbus, USA.

Erythema elevatum diutinum (EED) is a rare, chronic, cutaneous small vessel vasculitis of unclear pathogenesis. Classically, lesions present as symmetric red to purple plaques, papules, and nodules overlying joints. First-line therapy is dapsone. Read More

Hematol Transfus Cell Ther 2018 Apr-Jun;40(2):192-195. Epub 2018 Feb 17.

Centro Hospitalar de São João EPE, Porto, Portugal.

G Ital Dermatol Venereol 2018 Jun;153(3):439-440

Dermatopathological Laboratory, San Gallicano Institute, Rome, Italy.

J Dtsch Dermatol Ges 2018 May;16(5):617-620

Department of Dermatology, Venerology and Allergology, University Hospital Schleswig-Holstein, Campus Kiel, Germany.

J Dtsch Dermatol Ges 2018 May;16(5):616-619

Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Deutschland.

Am J Dermatopathol 2018 Oct;40(10):767-771

Department of Dermatology, Chang Gung Memorial Hospital, Linko, Taipei, Taiwan.

Scrub typhus is becoming a clinically important cause of acute undifferentiated febrile illness in Taiwan. The incubation period is between 6 and 21 days after exposure. It is transmitted by chiggers (larva of trombiculid mite) in long grasses and in dirt-floor homes, with infection characterized by a flu-like illness of fever, headache, and myalgia lasting approximately 1 week. Read More

Clin Lymphoma Myeloma Leuk 2018 05 19;18(5):e197-e200. Epub 2018 Mar 19.

Department of Hematology-Oncology, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon. Electronic address:

G Ital Dermatol Venereol 2018 Apr;153(2):285-286

Department of Dermatology, Faculty of Medicine, Umberto I Polyclinic Hospital, Sapienza University of Rome, Rome, Italy.

J Clin Rheumatol 2019 09;25(6):e93-e94

School of Medicine, University of Alabama at Birmingham, Birmingham, AL University of Central Florida, Orlando, FL

Dermatol Online J 2017 Oct 15;23(10). Epub 2017 Oct 15.

Harvard University, Cambridge, Massachusetts, Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts. michael_

Erythema elevatum diutinum (EED) is a rare, chronic small-vessel vasculitis that presents as firm, red, violaceous, or brown papules and nodules on the extensor surfaces of the limbs. Oral dapsone is considered first-line therapy for EED; in the current case report, a patient presenting with EED began dapsone treatment and symptoms subsided within two weeks. Seven months later, the patient became pregnant and stopped dapsone owing to her concerns with dapsone use during pregnancy, resulting in recurrence of EED symptoms. Read More

Int J Dermatol 2018 05 20;57(5):622-624. Epub 2018 Feb 20.

Department of Dermatology, University Hospital Complex, Santiago de Compostela, Spain.

Am J Surg Pathol 2018 04;42(4):529-533

Departments of Pathology.

Immunoglobulin A (IgA) vasculitis or Henoch-Schönlein purpura (HSP) typically occurs in the pediatric population, although rare cases also occur in adults. Gastrointestinal (GI) involvement is common. The "classic" histologic finding in IgA vasculitis (HSP) is leukocytoclastic vasculitis (LCV); other histologic features in biopsies of IgA vasculitis (HSP) have only been rarely described. Read More

Clin Exp Dermatol 2018 Jun 9;43(4):494-496. Epub 2018 Feb 9.

Department of Dermatology, Brigham and Women's Hospital, Boston, MA, USA.

J Allergy Clin Immunol Pract 2018 Sep - Oct;6(5):1744-1745. Epub 2018 Jan 19.

Department of Pathology, Hartford Hospital, East Hartford, Conn.

G Ital Dermatol Venereol 2018 Apr 24;153(2):265-272. Epub 2018 Jan 24.

Unit of Dermatology, Carlo Urbai Hospital, AREA Vasta 2 ASUR Marche, Jesi, Ancona, Italy -

The neutrophilic dermatoses (NDs) comprise a group of heterogeneous disorders characterized by inflammatory skin lesions that histologically show an intense inflammatory infiltrate composed primarily by neutrophils, with no evidence of infection or vasculitis. Although there are distinct clinical differences in the classical lesions of these disorders, many patients have overlapping features. In this review, we describe the clinical aspects of the main NDs, including: Sweet Syndrome, ND of the dorsal hands, pyoderma gangrenosum, erythema elevatum diutinum, subcorneal pustular dermatosis, neutrophilic eccrine hidradenitis, rheumatoid neutrophilic dermatitis, neutrophilic panniculitis, and aseptic abscesses including their association with underlying diseases and the differential diagnoses. Read More

Am J Dermatopathol 2018 Jun;40(6):442-444

Dermatopathology Department, Friedrichshafen Dermatopathologie, Friedrichshafen, Germany.

Erythema elevatum diutinum (EED) is a rare dermatosis with evolving histopathological features that vary according to the age of the lesions, with a variable fibrosis and a fascicled proliferation of spindle cells in late phases. The authors present an otherwise healthy 57-year-old woman with multiple indurated nodules on the inner aspect of both feet. Skin biopsy showed storiform interlacing bundles of spindled cells with plump nuclei and some areas with neutrophils and leukocytoclasia. Read More

J Cutan Pathol 2018 03 2;45(3):246-248. Epub 2018 Jan 2.

Department of Dermatology, Chinese PLA General Hospital & Medical School, Beijing, China.