132 results match your criteria Erythema Dyschromicum Perstans

Emerging Skin Toxicities in Patients with Breast Cancer Treated with New Cyclin-Dependent Kinase 4/6 Inhibitors: A Systematic Review.

Drug Saf 2021 May 6. Epub 2021 May 6.

Department of Dermatology, San Gallicano Dermatological Institute-IRCCS, Via Elio Chianesi 53, 00144, Rome, Italy.

Three cyclin-dependent kinases 4/6, including palbociclib, ribociclib, and abemaciclib, have been approved for the treatment of patients with hormone receptor-positive and human epidermal growth factor receptor 2-negative advanced breast cancer. The objective of this study was to evaluate the occurrence and clinical spectrum of cutaneous adverse events in patients with breast cancer following therapy with cyclin-dependent kinase 4/6 inhibitors. A systematic literature search was performed in the PubMed, Cochrane, and EMBASE databases up to November 2020 to evaluate studies published from 2015 to 2020. Read More

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Ribociclib-Induced Erythema Dyschromicum Perstans (Ashy Dermatosis)-Like Pigmentation in a Metastatic Breast Cancer Patient.

J Breast Cancer 2021 Feb;24(1):117-121

San Gallicano Dermatological Institute-IRCCS, Rome, Italy.

Ribociclib is a selective cyclin-dependent kinase (CDK) 4/6 inhibitor that has been approved in combination with endocrine therapy for the treatment of hormone receptor-positive/human epidermal growth factor 2-negative advanced or metastatic breast cancer. The main dermatological adverse events associated with CDK 4/6 inhibitors that are described in the literature include skin rash, an increased risk of alopecia, and stomatitis. Erythema dyschromicum perstans (EDP), also known as ashy dermatosis, is characterized by acquired small and large slate-gray hyperpigmented macules with erythematous borders. Read More

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February 2021

Ashy dermatosis-like hyperpigmentation in a patient taking hydroxyurea.

JAAD Case Rep 2020 Sep 25;6(9):797-800. Epub 2020 Jun 25.

Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas.

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September 2020

Erythema dyschromicum perstans in an infant with positive Darier sign: A case report successfully treated with tacrolimus.

Nazli Ercan

Dermatol Ther 2020 11 4;33(6):e14175. Epub 2020 Sep 4.

Division of Pediatric Allergy and Immunology, Department of Pediatrics, Gulhane Research and Training Hospital, University of Health Sciences, Ankara, Turkey.

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November 2020

Epidermal growth factor receptor inhibitor therapy-associated erythema dyschromicum perstans-like eruption: a case series.

Br J Dermatol 2020 12 2;183(6):1130-1132. Epub 2020 Sep 2.

Departments of, Department of, Dermatology, Stanford University Medical, Stanford, CA, USA.

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December 2020

Histopathological Study of Skin Lesions in a Tertiary Care Hospital: A Descriptive Cross-sectional Study.

JNMA J Nepal Med Assoc 2020 Apr 30;58(224):218-222. Epub 2020 Apr 30.

Department of Pathology, Kathmandu Medical College and Teaching Hospital, Sinamangal, Kathmandu, Nepal.

Introduction: Skin diseases are much common in developing countries. The spectrum varies according to geographic distribution, gender, age, and coexisting disorder. We conducted this study to find out the prevalence of different skin lesions and to evaluate their frequency and site of distribution. Read More

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Combination therapy with prednisone and isotretinoin in early erythema dyschromicum perstans: A retrospective series.

JAAD Case Rep 2020 Mar 19;6(3):207-213. Epub 2020 Feb 19.

Department of Dermatology, Kaiser Permanente, Panorama City, California.

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The color of skin: gray diseases of the skin, nails, and mucosa.

Clin Dermatol 2019 Sep - Oct;37(5):507-515. Epub 2019 Jul 31.

Department of Dermatology, Andrology and STIs, Ain Shams University Hospital, Cairo, Egypt. Electronic address:

Gray diseases are a group of skin disorders characterized mainly by gray discoloration with or without involving the mucous membranes and nails. These diseases may be hereditary or acquired. Some of the better-known hereditary entities are dermal melanocytosis, incontinentia pigmenti, hypomelanosis of Ito, hemochromatosis, ochronosis, and silvery hair syndrome. Read More

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Erythema dyschromicum perstans with a Wagyu beef-like appearance on dermoscopy.

J Eur Acad Dermatol Venereol 2020 Mar 12;34(3):e141-e142. Epub 2019 Dec 12.

Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

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Histological Evaluation of Acquired Dermal Macular Hyperpigmentation.

Indian Dermatol Online J 2019 Sep-Oct;10(5):542-546. Epub 2019 Aug 28.

Department of Pathology, Govt. Medical College, Kozhikode, Kerala, India.

Context: An umbrella term, acquired dermal macular hyperpigmentation (ADMH), has been proposed to denote conditions including ashy dermatosis, erythema dyschromicum perstans, lichen planus pigmentosus, and idiopathic macular eruptive pigmentation.

Aims: To classify the patients manifesting ADMH on the basis of histology.

Settings And Design: In this retrospective, cross-sectional study, histology specimens of patients of ADMH, who underwent skin biopsy in our institution from 1. Read More

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Proton pump inhibitor-induced erythema dyschromicum perstans-like pigmentation.

JAAD Case Rep 2019 Aug 5;5(8):701-703. Epub 2019 Aug 5.

Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York.

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Coexistence of hypopigmented mycosis fungoides and erythema dyschromicum perstans in a 3-year-old Chinese girl.

J Chen H Yu Z Yao

J Eur Acad Dermatol Venereol 2019 Dec 19;33(12):e492-e494. Epub 2019 Aug 19.

Department of Dermatology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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December 2019

Contact sensitization to hair colours in acquired dermal macular hyperpigmentation: results from a patch and photo-patch test study of 108 patients.

J Eur Acad Dermatol Venereol 2019 Jul 3;33(7):1349-1357. Epub 2019 Apr 3.

Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Background: Acquired dermal macular hyperpigmentation (ADMH) is an umbrella term including lichen planus pigmentosus, erythema dyschromicum perstans and pigmented contact/cosmetic dermatitis.

Objective: To establish contact sensitization to hair colours as an aetiological factor for ADMH.

Methods: Detailed clinical examination, skin biopsies, and patch and photo-patch testing with Indian standard series and patient's own cosmetic products were performed. Read More

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Acquired Macular Pigmentation of Unknown Etiology.

J Clin Aesthet Dermatol 2019 Jan 1;12(1):38-46. Epub 2019 Jan 1.

Dr. Udompanich and Dr. Vachiramon are with the Division of Dermatology, Faculty of Medicine Ramathibodi Hospital, Mahidol University in Bangkok, Thailand.

is a new umbrella term that encompasses a group of diseases that, while having similar clinical and histological features, their true entities are controversial, and a global consensus regarding these conditions is still lacking. The conditions comprised by the term are ashy dermatosis, erythema dyschromicum perstans, lichen planus pigmentosus, and idiopathic eruptive macular pigmentation. In this review, we compare the clinical and histological features of these conditions that comprise aquired macular pimgentation of unknown etiology, as well as review their responses to treatment. Read More

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January 2019

Erythema dyschromicum perstans: A case report and systematic review of histologic presentation and treatment.

Int J Womens Dermatol 2018 Dec 27;4(4):216-222. Epub 2018 Sep 27.

Department of Dermatology, Duke University Medical Center, Durham, North Carolina.

Objective: Erythema dyschromicum perstans (EDP) can be difficult to diagnose and treat; therefore, we reviewed the literature to assess whether histology can be used to differentiate lichen planus pigmentosus (LPP) from EDP and determine which treatments are the most effective for EDP. We also present a case of a patient who was treated successfully with narrow-band ultraviolet B (NB-UVB).

Methods: A systematic review in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses was conducted up to July 2017 using four databases. Read More

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December 2018

Literature Review of Treatment Outcomes for Lichen Planus Pigmentosus, Erythema Dyschromicum Perstans, and Ashy Dermatosis.

J Cutan Med Surg 2018 Nov/Dec;22(6):643-645

1 Department of Dermatology, The Queen Elizabeth Hospital, Woodville, South Australia.

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September 2019

A global consensus statement on ashy dermatosis, erythema dyschromicum perstans, lichen planus pigmentosus, idiopathic eruptive macular pigmentation, and Riehl's melanosis.

Int J Dermatol 2019 Mar 3;58(3):263-272. Epub 2018 Sep 3.

Department of Dermatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Ashy dermatosis (AD), lichen planus pigmentosus (LPP), erythema dyschromicum perstans (EDP), and idiopathic eruptive macular pigmentation are several acquired macular hyperpigmentation disorders of uncertain etiology described in literature. Most of the published studies on these disorders are not exactly comparable, as there are no clear definitions and different regions in the world describe similar conditions under different names. A consensus on the terminology of various morphologies of acquired macular pigmentation of uncertain etiology was a long-felt need. Read More

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Erythema Dyschromicum Perstans in an 8-Year-Old Indian Child.

Case Rep Dermatol Med 2018 15;2018:2143089. Epub 2018 Jul 15.

Clinical Associate Professor of Pediatrics at the University of British Columbia, Canada.

We report an 8-year-old East Indian boy with erythema dyschromicum perstans. The condition has very rarely been reported in prepubertal Indian children. A perusal of the literature revealed but two cases, to which we add another one. Read More

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A retrospective clinico-pathological study comparing lichen planus pigmentosus with ashy dermatosis.

Australas J Dermatol 2018 Nov 10;59(4):322-327. Epub 2018 Apr 10.

Department of Dermatology, National Skin Centre, Singapore City, Singapore.

Background/objectives: Controversy persists as to whether lichen planus pigmentosus and ashy dermatosis are separate clinical entities. This study was conducted to examine the clinicopathological features and treatment outcome of the two conditions.

Methods: A retrospective medical chart review of all patients who were diagnosed with lichen planus pigmentosus or ashy dermatosis was conducted. Read More

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November 2018

Erythema dyschromicum perstans in a child following an enteroviral meningitis.

An Bras Dermatol 2017 Jan-Feb;92(1):137-138

Pediatric Department, Centro Hospitalar do Médio Ave, Vila Nova de Famalicão, Portugal.

A healthy 6-year-old boy presented with an erythematous macular exanthema, meningeal signs and fever, initially diagnosed with probable bacterial meningitis and treated with antibiotic and anti-inflammatory drugs. Enteroviral meningitis was confirmed, but the skin lesions continued to evolve and the patient was ultimately diagnosed with erythema dyschromicum perstans. The boy was followed during three years until the spontaneous resolution of the dermatosis. Read More

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October 2017

A Case of Lichen Planus Pigmentosus with Facial Dyspigmentation Responsive to Combination Therapy with Chemical Peels and Topical Retinoids.

J Clin Aesthet Dermatol 2016 Nov 1;9(11):44-50. Epub 2016 Nov 1.

Residency Program Director, New York College of Osteopathic Medicine of New York Institute of Technology, Department of Dermatology, St. Barnabas Hospital, Bronx, New York.

Lichen planus pigmentosus is a photodistributed dyschromia of unknown etiology described clinically as hyperpigmented gray-blue or brown-black macules or patches in a photodistributed pattern. Although there has been some debate, lichen planus pigmentosus is considered by many to be a separate diagnostic entity from ashy dermatosis or erythema dyschromicum perstans, which shares similar characteristics. Various treatment strategies have been applied to help resolve or improve the appearance of lichen planus pigmentosus lesions; however, an optimal treatment method is yet to be elucidated. Read More

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November 2016

Coexistence of erythema dyschromicum perstans and vitiligo: a case report and review of the literature.

Funda Tamer

Acta Dermatovenerol Alp Pannonica Adriat 2016 Dec;25(4):77-78

Medical Park Hastanesi, Yenimahalle, Ankara, Turkey.

Erythema dyschromicum perstans is a rare, chronic, pigmentary disorder with unknown etiology. It clinically presents with oval to round, gray, blue, or brown macules of various sizes. The etiology remains unknown; however, cobalt allergy, radio contrast media, intestinal parasites, human immunodeficiency virus, and hypothyroidism have been proposed as causative factors. Read More

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December 2016

Lichen Planus Pigmentosus: The Controversial Consensus.

Indian J Dermatol 2016 Sep-Oct;61(5):482-6

Department of Dermatology, KPC Medical College and Hospital, Kolkata, West Bengal, India.

A pigmented variant of lichen planus (LP) was first reported from India in 1974 by Bhutani et al. who coined the term LP pigmentosus (LPP) to give a descriptive nomenclature to it. LP has a number of variants, one of which is LPP. Read More

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October 2016

Improvement of erythema dyschromicum perstans using a combination of the 1,550-nm erbium-doped fractionated laser and topical tacrolimus ointment.

Lasers Surg Med 2017 01 23;49(1):60-62. Epub 2016 Aug 23.

The Dermatology and Laser Surgery Center, Houston, Texas.

Background And Objective: Erythema dyschromicum perstans (EDP) is a cosmetically distressing, acquired pigmentary disorder of unknown etiology for which few successful therapies exist. Herein, we present the successful use of non-ablative fractional photothermolysis in combination with topical tacrolimus ointment.

Study Design/patients And Methods: A 35-year-old female with biopsy-confirmed EDP underwent a series of fractionated non-ablative treatment sessions utilizing the 1,550 nm erbium-doped fiber laser in combination with topical tacrolimus ointment over a period of 5 months. Read More

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January 2017

Seasonal variations in dermatologic and dermatopathologic diagnoses: a retrospective 15-year analysis of dermatopathologic data.

Int J Dermatol 2016 Oct 7;55(10):1115-8. Epub 2016 Apr 7.

Temple University School of Medicine, Philadelphia, PA, USA.

Background: Certain dermatologic conditions are known to show seasonal variations in frequency, the reasons for which are unclear but in some cases may be attributable to changes in ambient weather conditions.

Objectives: The current study was conducted to determine whether seasonal trends might exist for dermatologic conditions including erythema multiforme, guttate psoriasis, erythema dyschromicum perstans (ashy dermatosis), pityriasis lichenoides, and pityriasis rosea.

Methods: Data were derived from a 15-year retrospective review of electronic records from a large dermatopathology laboratory located in the mid-Atlantic region of the USA. Read More

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October 2016

Erythema dyschromicum perstans showing resolution in an adult.

JAAD Case Rep 2015 Jul 10;1(4):185-7. Epub 2015 Jun 10.

Department of Dermatology, Columbia University, New York, New York.

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Erythema Dyschromicum Perstans Response to Isotretinoin.

JAMA Dermatol 2016 07;152(7):841-2

Department of Dermatology, The Eastern Hospital of The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

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Macular pigmentation of uncertain aetiology revisited: two case reports and a proposed algorithm for clinical classification.

Australas J Dermatol 2017 Feb 1;58(1):45-49. Epub 2016 Feb 1.

Department of Dermatology, Fiona Stanley Hospital, Perth, Western Australia, Australia.

Ashy dermatosis, erythema dyschromicum perstans, lichen planus pigmentosus and idiopathic eruptive macular pigmentation are various types of acquired macular hyperpigmentation disorders of the skin described in literature. However, a global consensus on the definitions of these entities is lacking. We report two cases of acquired macular (hyper)pigmentation of uncertain aetiology diagnosed as ashy dermatosis and attempt to clarify the various confusing nosologies based on existing literature. Read More

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February 2017

"Melanocytic Nests Arising in Lichenoid Inflammation": Reappraisal of the Terminology "Melanocytic Pseudonests".

Am J Dermatopathol 2015 Dec;37(12):940-3

*Department of Dermatology, Dermatopathology Section, Boston University School of Medicine, Boston, MA; and †Chelmsford Dermatology, P.C., Chelmsford, MA.

Pseudonests or pseudomelanocytic nests represent aggregates of cells and cell fragments, including keratinocytes, macrophages, lymphocytes, and occasional melanocytes. Pseudomelanocytic nests in the setting of lichenoid inflammation can mimic atypical melanocytic proliferations. Several reports documented nonspecific staining of pseudonests with melanoma antigen recognized by T cells-1/Melan-A, which can be detected in the cytoplasm of nonmelanocytic cells. Read More

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December 2015

Erythema Dyschromicum Perstans: Response to Topical Tacrolimus.

Indian J Dermatol 2015 Sep-Oct;60(5):525

Department of Dermatology, Venereology and Leprosy, Dr. R. P. Govt. Medical College, Kangra, Tanda, Himachal Pradesh, India.

Background: Erythema dyschromicum perstans, a rare dermatosis of obscure etiopathogenesis and significant cosmetic morbidity, have no satisfactory treatment.

Observations: Two patients with having characteristic asymptomatic and slowly progressive, slate-grey macular lesions with distinct red borders involving the face, neck, upper trunk and limbs were diagnosed clinicopathologically as erythema dyschromicum perstans. Both were treated successfully with topical tacrolimus 0. Read More

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November 2015