46,109 results match your criteria Erythema Multiforme Stevens-Johnson Syndrome

Warfarin-induced Stevens-Johnson syndrome with severe liver injury.

J Int Med Res 2021 Jul;49(7):3000605211033196

Department of Dermatology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a life-threatening mucocutaneous disease that is predominantly drug-induced. Warfarin is the most commonly used drug for long-term anti-coagulant therapy; however, warfarin-induced SJS/TEN is seldom reported. In this study, we presented the case of a 61-year-old man who developed SJS after receiving multiple-drug therapy following aortic valve replacement surgery. Read More

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Eccrine angiomatous hamartoma: First case in the cytology literature.

Ann Diagn Pathol 2021 Jul 17;54:151796. Epub 2021 Jul 17.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, USA. Electronic address:

A 34-year-old male presented with a swelling on the volar surface of the third digit of his right hand. This swelling was associated with pain and erythema. Ultrasound-guided needle biopsy was performed. Read More

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A cross-industry survey on photosafety evaluation of pharmaceuticals after implementation of ICH S10.

Regul Toxicol Pharmacol 2021 Jul 24;125:105017. Epub 2021 Jul 24.

Translational Research, SeaGen Inc., Bothell, WA, USA.

A cross-industry survey was conducted by EFPIA/IQ DruSafe in 2018 to provide information on photosafety evaluation of pharmaceuticals after implementation of ICH S10. This survey focused on the strategy utilized for photosafety risk assessment, the design of nonclinical (in vitro and in vivo) and clinical evaluations, the use of exposure margins in risk assessment, and regulatory interactions. The survey results indicated that a staged approach for phototoxicity assessment has been widely accepted by regulatory authorities globally. Read More

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Acute Generalized Exanthematous Pustulosis Overlapping with Toxic Epidermal Necrolysis Successfully Treated by Etanercept.

J Eur Acad Dermatol Venereol 2021 Jul 26. Epub 2021 Jul 26.

Division of Dermatology, McGill University Health Centre, Montreal, QC, Canada.

Acute generalized exanthematous pustulosis (AGEP) is a rare and severe cutaneous adverse drug reaction (SCAR) characterized by rapid development of sterile pustules on edematous erythema, leukocytosis and fever . Rarely, a toxic epidermolytic necrolysis (TEN)-like variant can occur. While prompt drug discontinuation and supportive care with moisturizers or topical steroids suffice for milder cases, this variant deserves special attention given the higher risk of overlap with toxic epidermal necrolysis and TEN-like complications . Read More

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TNF-α inhibitor-induced paradoxical psoriasis and erythema nodosum in a patient with ankylosing spondylitis.

Eur J Dermatol 2021 Jun;31(3):412-413

Department of Dermatology, Iwate Medical University School of Medicine, 2-1-1, Idaidori, Yahaba-cho, Iwate 028-3695, Japan.

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Increased prevalence of irritant hand eczema in health care workers in a dermatological clinic due to increased hygiene measures during the SARS-CoV-2 pandemic.

Eur J Dermatol 2021 Jun;31(3):392-395

Department of Dermatology and Allergy University Hospital, Ludwig Maximilian University of Munich, 80337 Munich, Germany Munich, Germany.

Background: Hand hygiene measures in the general population and in health care workers have increased considerably since the outbreak of the COVID-19 pandemic.

Objectives: To investigate the prevalence and symptoms of hand eczema, as well as hygiene measures and concepts of care, in German health care workers.

Materials & Methods: This was an observational questionnaire study to investigate hygiene and skin care habits, as well as the prevalence and symptoms of hand eczema in 66 nurses and doctors of our dermatology department before and during the SARS-CoV-2 pandemic. Read More

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β2-adrenoreceptors control human skin microvascular reactivity.

Eur J Dermatol 2021 Jun;31(3):326-334

Department of Pharmacology, Faculty of Medicine, University of Valencia, Spain, CIBERES, Health Institute Carlos III, Valencia, Spain, Research and teaching Unit, University General Hospital Consortium, Valencia, Spain.

Topical α1- and α2-adrenoreceptor (ADRA1 and 2) agonists are effective in alleviating permanent vasodilation and facial erythema associated with rosacea by inducing skin vasoconstriction. Although β-adrenoreceptor (ADRB) antagonists are used off-label for rosacea, pharmacological and pharmacodynamic data pertaining to these receptors in skin micro-vessels are lacking. Objectives: To analyse the expression of different adrenergic receptors and their contribution to vasoreactivity in skin micro-vessels. Read More

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Pyoderma Gangrenosum after Breast Mammoplasty Surgery: A Case Report.

World J Plast Surg 2021 May;10(2):103-106

Department of Plastic and Reconstructive Surgery, Centro Hospitalar Conde São Januário, Macau SAR.

Pyoderma gangrenosum (PG) is a rare inflammatory neutrophilic dermatosis, characterized by painful ulcerative, bullous, or pustular skin conditions. Pathergy is usually used to describe PG which refers to initiation or exacerbation of the disease after accidental or iatrogenic skin trauma. Diagnosis of postoperative PG is challenging not only due to its presentation mimics infectious wounds, but also because there are no standard laboratory parameters for diagnosis. Read More

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Acute generalized exanthematous pustulosis in a postpartum woman.

Clin Case Rep 2021 Jul 21;9(7):e04462. Epub 2021 Jul 21.

Department of Infectious Diseases Japanese Red Cross Ise Hospital Ise Japan.

The distribution of pustular erythema, characteristic clinical course, and pathological findings can help diagnose acute generalized exanthematous pustulosis. Clinical management should include discontinuation of the suspected drug, hydrocortisone administration, and careful follow-up examination. Read More

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Atypical erythema in a child with celiac disease.

Clin Case Rep 2021 Jul 21;9(7):e04441. Epub 2021 Jul 21.

Institute of Dermatology Fondazione IRCCS Policlinico San Matteo University of Pavia Pavia Italy.

Herpetiformis dermatitis is the best characterized extraintestinal manifestation of celiac disease (CD). However, other chronic heterogeneous skin lesions have been associated with CD and should be considered in the differential diagnosis. Read More

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Review of oral ulcerative lesions in COVID-19 patients: a comprehensive study of 51 cases.

J Dent Sci 2021 Jul 15. Epub 2021 Jul 15.

Department of Dentistry, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.

Numerous oral manifestations of COVID-19 have been reported in the literatures. Common oral lesions in COVID-19 patients included ulcerations, xerostomia, dysgeusia, gingival inflammation, and erythema. Among them, oral ulceration is the most frequent finding and is present as various but distinct patterns. Read More

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The combined detection of autoantibody characteristics in systemic lupus erythematosus.

Am J Transl Res 2021 15;13(6):7242-7248. Epub 2021 Jun 15.

Medical Research & Laboratory Diagnostic Center, Jinan Central Hospital Affiliated to Shandong First Medical University Jinan 250013, Shandong Province, China.

Objective: To investigate the combined detection of the autoantibody characteristics in systemic lupus erythematosus (SLE).

Methods: 105 SLE patients admitted to our hospital from May 2019 to September 2020 were placed in the SLE examination group (the SE group), 110 patients with rheumatic diseases admitted to our hospital during the same period were placed in the disease control group (the DC group), and 100 healthy people who came to our hospital for physical examinations during the same time period were placed in the healthy control group (the HC group). The SLE patients' clinical data were recorded. Read More

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[Pasteurellosis breast implant infection: A case report and literature review].

Ann Chir Plast Esthet 2021 Aug;66(4):338-340

Département de chirurgie plastique esthétique et reconstructrice, hôpital de Hautepierre, hôpitaux universitaires de Strasbourg, avenue Molière, 67200 Strasbourg, France; Université de Strasbourg, Strasbourg, France. Electronic address:

Breast implant infection is a potential complication after surgery. This case reports an unusual infection. A patient undergoes a skin sparing mastectomy for a carcinoma with an immediate breast implant reconstruction. Read More

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Sensory defunctionalization induced by 8% topical capsaicin treatment in a model of ultraviolet-B-induced cutaneous hyperalgesia.

Exp Brain Res 2021 Jul 24. Epub 2021 Jul 24.

Laboratory for Experimental Cutaneous Pain and Itch Research, SMI, Department of Health Science and Technology, Center for Neuroplasticity and Pain, Faculty of Medicine, Aalborg University, Fredrik Bajers Vej 7D, 9220, Aalborg, Denmark.

Subpopulations of primary nociceptors (C- and Aδ-fibers), express the TRPV1 receptor for heat and capsaicin. During cutaneous inflammation, these afferents may become sensitized, leading to primary hyperalgesia. It is known that TRPV1 nociceptors are involved in heat hyperalgesia; however, their involvement in mechanical hyperalgesia is unclear. Read More

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Efficacy of Photobiomodulation in the Treatment of Cancer Chemotherapy-Induced Oral Mucositis: A Meta-Analysis with Trial Sequential Analysis.

Int J Environ Res Public Health 2021 Jul 12;18(14). Epub 2021 Jul 12.

Division of Restorative Dentistry, International Medical University, Kuala Lumpur 57000, Malaysia.

Oral mucositis is a debilitating complication of chemotherapy, characterized by erythema, ulcers and oedema of the oral mucosa. This review aimed to evaluate the efficacy of Photobiomodulation in the treatment of oral mucositis using meta-analysis and trial sequential analysis, and also to assess the quality of the results by Grading of Recommendations, Assessment, Development and Evaluation (GRADE). A comprehensive search of three databases, including Embase, Medline and Central, was performed to identify randomized controlled trials studying the efficacy of Photobiomodulation in the treatment of cancer chemotherapy-induced oral mucositis. Read More

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Oleogel Formulations for the Topical Delivery of Betulin and Lupeol in Skin Injuries-Preparation, Physicochemical Characterization, and Pharmaco-Toxicological Evaluation.

Molecules 2021 Jul 9;26(14). Epub 2021 Jul 9.

Research Centre for Pharmaco-Toxicological Evaluation, "Victor Babeș" University of Medicine and Pharmacy, 2nd Eftimie Murgu Square, RO-300041 Timișoara, Romania.

The skin integrity is essential due to its pivotal role as a biological barrier against external noxious factors. Pentacyclic triterpenes stand as valuable plant-derived natural compounds in the treatment of skin injuries due to their anti-inflammatory, antioxidant, antimicrobial, and healing properties. Consequently, the primary aim of the current investigation was the development as well as the physicochemical and pharmaco-toxicological characterization of betulin- and lupeol-based oleogels (Bet OG and Lup OG) for topical application in skin injuries. Read More

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Diagnostic Tools and Biomarkers for Severe Drug Eruptions.

Int J Mol Sci 2021 Jul 14;22(14). Epub 2021 Jul 14.

Department of Dermatology, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan.

In accordance with the development of human technology, various medications have been speedily developed in the current decade. While they have beneficial impact on various diseases, these medications accidentally cause adverse reactions, especially drug eruption. This delayed hypersensitivity reaction in the skin sometimes causes a life-threatening adverse reaction, namely Stevens-Johnson syndrome and toxic epidermal necrolysis. Read More

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Cd34+ Stromal Cells/Telocytes in Normal and Pathological Skin.

Int J Mol Sci 2021 Jul 8;22(14). Epub 2021 Jul 8.

Department of Basic Medical Sciences, Faculty of Medicine, University of La Laguna, 38071 Tenerife, Spain.

We studied CD34+ stromal cells/telocytes (CD34+SCs/TCs) in pathologic skin, after briefly examining them in normal conditions. We confirm previous studies by other authors in the normal dermis regarding CD34+SC/TC characteristics and distribution around vessels, nerves and cutaneous annexes, highlighting their practical absence in the papillary dermis and presence in the bulge region of perifollicular groups of very small CD34+ stromal cells. In non-tumoral skin pathology, we studied examples of the principal histologic patterns in which CD34+SCs/TCs have (1) a fundamental pathophysiological role, including (a) fibrosing/sclerosing diseases, such as systemic sclerosis, with loss of CD34+SCs/TCs and presence of stromal cells co-expressing CD34 and αSMA, and (b) metabolic degenerative processes, including basophilic degeneration of collagen, with stromal cells/telocytes in close association with degenerative fibrils, and cutaneous myxoid cysts with spindle-shaped, stellate and bulky vacuolated CD34+ stromal cells, and (2) a secondary reactive role, encompassing dermatitis-e. Read More

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Early Diagnosis and Surgical Management of Necrotizing Fasciitis of the Lower Extremities: Risk Factors for Mortality and Amputation.

Adv Wound Care (New Rochelle) 2021 Jul 22. Epub 2021 Jul 22.

Department of Plastic and Reconstructive Surgery, MedStar Georgetown University Hospital, Washington, District of Columbia, USA.

In this study, we seek to identify patient characteristics associated with limb loss and mortality while exploring the potential impact a multidisciplinary care team may have. This was a 10-year retrospective review of patients presenting to our tertiary care center for limb salvage with a diagnosis of lower extremity (LE) necrotizing fasciitis (NF). Patient demographics, clinical history, and outcomes were compared between survivors and nonsurvivors and between those who underwent LE amputation and those who did not. Read More

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Correlation between Metal Ions and Cytokines in the Saliva of Patients with Oral Lichenoid Lesions.

Yonsei Med J 2021 Aug;62(8):767-775

Department of Oral Medicine, School of Dentistry, Pusan National University, Dental Research Institute, Dental and Life Science Institute, Yangsan, Korea.

Purpose: We aimed to investigate the effect of metal ions from oral prostheses (OPs) released into the saliva of patients with oral lichenoid lesions (OLLs).

Materials And Methods: Subjects (n=183) were divided into four groups according to the presence or absence of OLL and OP. Concentrations of the metal ions titanium, chromium (Cr), cobalt (Co), nickel (Ni), palladium (Pd), silver (Ag), platinum (Pt), gold (Au), and zirconium (Zr) were measured using a laser-ablation microprobe inductively coupled to a plasma mass spectrometer. Read More

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Surgical Versus Medical Management of Necrotizing Enterocolitis With and Without Intestinal Perforation: A Retrospective Chart Review.

Cureus 2021 Jun 17;13(6):e15722. Epub 2021 Jun 17.

Neonatology, Kind Fahad Hospital, Al Baha, SAU.

Background Necrotizing enterocolitis (NEC) is a debilitating disease that predominantly afflicts premature neonates, although it can also affect term neonates. The clinical features of the ailment vary widely and range from transient feed intolerance to life-threatening complications such as septicemia and disseminated intravascular coagulation. While surgery is usually only reserved for severe cases, such as those presenting with intestinal perforation, the role of surgical management in cases of NEC without perforation remains elusive. Read More

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Correlation of Measures From the OCULUS Keratograph and Clinical Assessments of Dry Eye Disease in the Dry Eye Assessment and Management Study.

Cornea 2021 Jul 22. Epub 2021 Jul 22.

Department of Ophthalmology, University of Kansas, Prairie Village, KS; Department of Ophthalmology, University of Pennsylvania, Philadelphia, PA; School of Optometry, University of California, Berkeley, CA; Department of Mathematics, Cornell University, Ithaca, NY; Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY; and Department of Ophthalmology, University of Tennessee, Memphis, TN.

Purpose: The purpose of this study was to compare objective, noninvasive assessments of tear function using the OCULUS Keratograph with the corresponding clinical assessments [tear break-up time (TBUT), Schirmer test, and bulbar erythema] among patients with moderate-to-severe dry eye disease.

Methods: Participants in the Dry Eye Assessment and Management study at centers having an OCULUS Keratograph were assessed using standardized procedures. Associations between the assessments from the Keratograph [noninvasive keratograph break-up time (NIKBUT), tear meniscus height (TMH), and bulbar redness (BR)] and clinical examination (TBUT, Schirmer test, and bulbar erythema) and between these test results and Ocular Surface Disease Index (OSDI) scores were summarized with Spearman correlation coefficients (rs); 95% confidence intervals (95% CI) accounted for intereye correlation. Read More

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Bullous drug eruption after second dose of mRNA-1273 (Moderna) COVID-19 vaccine: Case report.

J Infect Public Health 2021 Jul 8. Epub 2021 Jul 8.

Icahn School of Medicine at Mount Sinai/NYC Health + Hospitals Queens, NY, USA. Electronic address:

Background: In December 2020, Moderna released the mRNA-1273 vaccine. The most common side effects are headache, muscle pain, redness, swelling, and tenderness at the injection site. In addition, there have been dermatological adverse events, such as hypersensitivity reactions. Read More

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Intradermal lipopolysaccharide challenge as an acute in vivo inflammatory model in healthy volunteers.

Br J Clin Pharmacol 2021 Jul 22. Epub 2021 Jul 22.

Centre for Human Drug Research, Leiden, the Netherlands.

Introduction: Whereas intravenous administration of TLR4 ligand lipopolysaccharide (LPS) to human volunteers is frequently used in clinical pharmacology studies, systemic use of LPS has practical limitations. We aimed to characterize the intradermal LPS response in healthy volunteers, and as such qualify the method as local inflammation model for clinical pharmacology studies.

Methods: 18 healthy male volunteers received two or four intradermal 10 ng LPS injections and one saline injection on the forearms. Read More

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Spheno-Orbital Dermoid Masquerading as Recurrent Orbital Abscess.

Ophthalmic Plast Reconstr Surg 2021 Jul 21. Epub 2021 Jul 21.

phthalmic Plastic Surgery Service, Department of Ophthalmology, Massachusetts Eye and Ear Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, U.S.A. Ophthalmic Plastic Surgery, Department of Ophthalmology, Yale University, New Haven, Connecticut, U.S.A.

A 10-month-old girl presented with eyelid edema and erythema that did not improve with systemic antibiotics. Due to a lack of improvement, MRI was performed to avoid ionizing radiation from CT. An orbital abscess was recognized and drained. Read More

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Neonatal Fournier's Gangrene: Avoiding Extensive Debridement.

Pediatr Infect Dis J 2021 Jul 20. Epub 2021 Jul 20.

From the Division of Plastic Pediatric Surgery, Pediatric Surgery Department Neonatology Department Pediatric Surgery Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Fournier's gangrene is a necrotizing fasciitis of the scrotal and inguinal region, associating high mortality and complication rates. It is extremely rare in the neonatal period and may be life threatening. We present an exceptional case of a 24-day-old boy who consulted to the emergency department for fever (39 °C) and an indurated, fluctuating and painful erythema in both groins, left hemiscrotum, left anterior femoral region and perineum for the last 6 hours. Read More

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Discovery of a large axillary artery vascular malformation during the evaluation of a patient with hemodialysis access-induced distal ischemia: Implications on pathophysiology and management.

Semin Dial 2021 Jul 22. Epub 2021 Jul 22.

Renal Division, Department of Internal Medicine, Houston Methodist Hospital, Houston, Texas, USA.

A patient with a 6-year-old left upper arm brachial cephalic AVF presented with symptoms of hemodialysis access-induced distal ischemia (HAIDI). Physical exam findings showed a well-developed AVF, but compression of the AVF aggravated arm pain and induced diffuse erythema of the left upper extremity. Angiographic evaluation disclosed the presence of a large axillary artery vascular malformation (AVM) as well as distal forearm hypo-perfusion. Read More

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T-Regulatory Cells in Erythema Nodosum Leprosum: An Immunohistochemical and Image Morphometric Study.

Am J Dermatopathol 2021 Jul 20. Epub 2021 Jul 20.

Departments of Pathology and Lab Medicine, and. Dermatology, AIIMS, Bhubaneswar, Odisha.

Abstract: Erythema nodosum leprosum (ENL) occurs as an immune-inflammatory complication of multibacillary leprosy (MBL), precipitated by an interaction between the host, bacilli, and the environment. This complication often causes significant morbidity due to systemic involvement and needs to be treated aggressively. T-regulatory cells (T-regs) are the immunomodulatory subset of T cells that are hypothesized to play a role in ENL. Read More

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Pulsed dye laser versus intense pulsed light for facial erythema of rosacea: A systematic review and meta-analysis.

J Dermatolog Treat 2021 Jul 22:1-8. Epub 2021 Jul 22.

Department of Dermatology, Taipei Medical University Hospital, Taipei, Taiwan.

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Case Report: Severe Rashes Associated With Fruquintinib in a Patient With Metastatic Colorectal Cancer.

Front Oncol 2021 5;11:688231. Epub 2021 Jul 5.

Department of Medical Oncology, Affiliated Hangzhou Cancer Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Metastatic colorectal cancer (mCRC) is a common and high-risk malignant tumor. Fruquintinib is a novel small-molecule compound with high selective inhibition of vascular endothelial growth factor (VEGF) receptor (VEGFR) for mCRC for which second-line or higher standard chemotherapy has been ineffective. A female patient with mCRC developed severe rashes after 2 weeks of taking fruquintinib. Read More

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