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J Dtsch Dermatol Ges 2022 Jun 27. Epub 2022 Jun 27.

Department of Dermatology, Venereology and Allergology, Division of Evidence-Based Medicine (dEBM), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany.

Acute or chronic redness of the lower leg is a frequent reason for visits to clinics and practices. The differential diagnosis is often challenging. The aim of this guideline is to define criteria and procedures for the differential diagnosis of acute or chronic, unilateral or bilateral redness of the lower leg. Read More

J Am Acad Dermatol 2022 Jun 6. Epub 2022 Jun 6.

Department of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA; Rocky Mountain Regional Veterans Affairs Medical Center, Eastern Colorado Health Care System, Aurora, Colorado, USA.

Eur J Dermatol 2022 Jan;32(1):94-98

Background Skin is one of the organs associated with Serratia marcescens infection. The associated morbidity can be significant, however, information is lacking. Objectives To identify characteristics of cases with cutaneous infection of Serratia marcescens. Read More

Vet Microbiol 2022 Jul 12;270:109458. Epub 2022 May 12.

Nippon Institute for Biological Science, 9-2221-1 Shin-machi, Ome, Tokyo 198-0024, Japan; Medical Mycology Research Center, Chiba University, 1-8-1 Inohana, Chiba 260-8673, Japan.

Erysipelothrix rhusiopathiae causes swine erysipelas (SE) and is classified -into 16 serovars based on cell surface antigens. Our previous study suggested that recent SE outbreaks were mostly caused by serovar 1a of E. rhusiopathiae with the surface protective antigen (Spa)A protein characterized by methionine and isoleucine at positions 203 and 257 (M203/I257 SpaA). Read More

Mol Clin Oncol 2022 Jun 11;16(6):110. Epub 2022 May 11.

Second Department of Medical Oncology, General Oncology Hospital of Kifissia 'Agioi Anargiroi', Athens 14564, Greece.

Gastric cancer (GC) is the fifth most commonly diagnosed malignancy and the fourth leading cause of cancer death worldwide. Skin metastases from internal organs are rare; skin metastasis from GC occurs even more rarely than skin metastases originating from other organs, and is associated with systematic disease and poor prognosis. The present study described an interesting and rare case of an extensive skin rash in a 42-year-old man diagnosed with GC, which was mainly affecting his left hemithorax, abdomen and back. Read More

Int J Dermatol 2022 May 24. Epub 2022 May 24.

Department of Dermatology, University of Sfax, Sfax, Tunisia.

Background: Erysipeloid cutaneous leishmaniasis (ECL) is known as the chronic form of cutaneous leishmaniasis (CL). However, keeping its clinical presentation in view, there is a need to revisit this form of the disease.

Aims: To describe ECL in view of clinical features and treatment modalities. Read More

Front Vet Sci 2022 6;9:774836. Epub 2022 May 6.

Infectious Diseases Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, South Korea.

Erysipelas, caused by , is considered one of the most serious infectious diseases of captive and free-ranging cetaceans worldwide, as these animals are known to be highly susceptible to the bacterial infections. The potential diversity between isolates from captive cetaceans has been previously described; however, the microbiological features of the free-ranging cetacean isolates remain unclear. Here, we describe a case of bacteremia in a rough-toothed dolphin () caused by . Read More

J Vasc Surg Venous Lymphat Disord 2022 May 10. Epub 2022 May 10.

Department of Surgery, University of Arizona College of Medicine, Tucson, AZ. Electronic address:

Objectives: To assess through literature case analysis how advances in lymphatic imaging, interventional radiology, and lymphatic vascular microsurgery illuminate and improve the lymphatic-flow status in select patients with Noonan syndrome (NS) who have undergone surgical intervention as a part of their comprehensive and individualized treatment plan. Also, we sought to illustrate the spectrum of lymphatic complications that can occur in this patient population when lymphatic flow through abnormal vasculature is surgically disrupted.

Methods: A literature review was performed by searching "Noonan AND Lymphatic AND Imaging" in the PubMed database. Read More

Cancer Treat Res 2022 ;183:1-48

Fred Hutchinson Cancer Research Center and University of Washington, 1100 Fairview Avenue, Seattle, WA, 98109, USA.

Cancer immunotherapy, or the utilization of components of the immune system to target and eliminate cancer, has become a highly active area of research in the past several decades and a common treatment strategy for several cancer types. The concept of harnessing the immune system for this purpose originated over 100 years ago when a physician by the name of William Coley successfully treated several of his cancer patients with a combination of live and attenuated bacteria, later known as "Coley's Toxins", after observing a subset of prior patients enter remission following their diagnosis with the common bacterial infection, erysipelas. However, it was not until late in the twentieth century that cancer immunotherapies were developed for widespread use, thereby transforming the treatment landscape of numerous cancer types. Read More

Plast Reconstr Surg Glob Open 2022 May 6;10(5):e4314. Epub 2022 May 6.

Department of Clinical Sciences, Malmö, Lund University, Sweden.

Background: Skin infections are a recurring problem for people with lymphedema, and lymphedema has been proven to be the single most important risk factor for developing erysipelas in the leg. This study aimed to determine whether liposuction for late-stage lymphedema reduces the rate of erysipelas in lower extremity lymphedema.

Methods: One-hundred twenty-four patients with a median age of 49 years who had liposuction and controlled compression therapy for lower extremity lymphedema were included. Read More

Ned Tijdschr Geneeskd 2022 03 24;166. Epub 2022 Mar 24.

Nij Smellinghe, afd. Dermatologie, Drachten.

Chronic edema is caused by lymphatic impairment due to either overload of interstitial fluid or anatomic/functional lymphatic failure in any part of the body. Lymphatics play a crucial role in interstitial homeostasis, immune surveillance and fat absorption in the gut. Lymphedema is a clinical sign with swelling and not a diagnosis. Read More

Cureus 2022 Mar 24;14(3):e23445. Epub 2022 Mar 24.

Internal Medicine, St. Peter's University Hospital, New Brunswick, USA.

Carcinoma erysipeloides (CE) is an atypical finding among women with breast cancer. CE clinically presents as an erythematous patch or plaque resembling superficial skin infections such as cellulitis or erysipelas. CE can also be the first indication of an underlying breast cancer. Read More

Med Clin North Am 2022 May 4;106(3):537-543. Epub 2022 Apr 4.

Department of Internal Medicine, The Ohio State University College of Medicine, M112 Starling Loving Hall, 310 W 10th Avenue, Columbus, OH 43210, USA. Electronic address:

This article reviews the presentation, physical examination findings, and diagnosis of selective common acute infectious diseases. In this article, we review nonpurulent skin infections, infective endocarditis, and acute cholecystitis. Read More

Biomolecules 2022 04 18;12(4). Epub 2022 Apr 18.

Centre de Ressources en Information Scientifique, Institut Pasteur, 75015 Paris, France.

Louis Pasteur is the most internationally known French scientist. He discovered molecular chirality, and he contributed to the understanding of the process of fermentation, helping brewers and winemakers to improve their beverages. He proposed a process, known as pasteurization, for the sterilization of wines. Read More

J Physiother 2022 04 12;68(2):110-122. Epub 2022 Apr 12.

Department of Rehabilitation Sciences, KU Leuven, Leuven, Belgium; Department of Rehabilitation Sciences and Physiotherapy, University of Antwerp, Antwerp, Belgium.

Questions: When added to decongestive lymphatic therapy (DLT), what is the effect of fluoroscopy-guided manual lymphatic drainage (MLD) versus traditional MLD or placebo MLD for the treatment of breast cancer-related lymphoedema (BCRL)?

Design: Multicentre, three-arm, randomised controlled trial with concealed allocation, intention-to-treat analysis and blinding of assessors and participants.

Participants: At five hospitals in Belgium, 194 participants with unilateral chronic BCRL were recruited.

Intervention: All participants received standard DLT (education, skin care, compression therapy and exercises). Read More

Infez Med 2022 1;30(1):129-133. Epub 2022 Mar 1.

Department of General Internal Medicine, Akashi Medical Center, Hyogo, Japan.

Hereditary hemorrhagic telangiectasia (HHT) is a risk of infection, such as by brain abscess associated with pulmonary arteriovenous malformations. However, association between HHT and recurrent erysipelas is not well described. HHT can cause vessel malformations in organs, leading to various serious outcomes. Read More

JPRAS Open 2022 Jun 24;32:79-87. Epub 2022 Feb 24.

Department of Plastic Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

We analyzed treatment, outcome, and risk factors for skin necrosis of 60 patients aged ≥65 years treated for a pretibial hematoma in the province of Kymenlaakso, Finland, between 2015 and 2019. Reviewing patients' medical records revealed two cohorts with distinct trajectories in outcome. By comparing the cohorts, we were able to discover factors associated with the prognosis for generating skin necrosis and the need for operative treatment. Read More

Growth Factors 2021 Feb-Jul;39(1-6):45-58. Epub 2022 Mar 21.

Lawrence Berkeley National Laboratory, Molecular Biophysics & Integrated Bioimaging Division, Berkeley, CA, USA.

Background: "Quantile-dependent expressivity" occurs when the effect size of a genetic variant depends upon whether the phenotype (e.g. growth factor concentration) is high or low relative to its distribution. Read More

J Microbiol Immunol Infect 2022 Mar 3. Epub 2022 Mar 3.

Department of Pediatrics, MacKay Children's Hospital and MacKay Memorial Hospital, Taipei, Taiwan; Department of Medicine, MacKay Medicine College, New Taipei, Taiwan. Electronic address:

Purpose: This study aimed to describe the etiology, clinical features, hospital course, and outcomes of hospitalized children with skin and soft tissue infections (SSTIs) and to test if clinical and laboratory variables at admission could differentiate between community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) and community-acquired methicillin-sensitive S. aureus (CA-MSSA).

Methods: We reviewed the clinical, laboratory, treatment, and outcome data for children hospitalized with SSTIs, aged 0-18 years at MacKay Children's Hospital between 2010 and 2019. Read More

Hautarzt 2022 Mar;73(3):222

Klinik und Poliklinik für Dermatologie und Venerologie, Universitätsklinikum Köln, Köln, Deutschland.

JAAD Case Rep 2022 Mar 8;21:74-76. Epub 2022 Jan 8.

Ronald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, New York, New York.

Allergol Select 2022 1;6:27-32. Epub 2022 Feb 1.

Department of Dermatology and Venereology, University Hospital Halle, Martin-Luther-University Halle-Wittenberg, Halle, Germany.

The administration of alternative broad-spectrum antibiotics because of a suspected allergy to beta-lactam antibiotics (BLA) is one reason for the increase in bacterial resistance to antibiotics and results in further problems, such as reduced efficiency against the causative bacteria, longer hospital stays, higher prices, and more adverse events. Patients with documented BLA allergy experience infections and postoperative surgical-site infections more frequently than patients without this label. Yet, in cases of documented and even proven IgE-mediated allergy to a BLA, such as penicillin or cephalosporin, the careful application of a different BLA with dissimilar core and side chains is possible. Read More

Sci Rep 2022 02 7;12(1):2006. Epub 2022 Feb 7.

School of Biology & Baslc Medical Sciences, Soochow University, Suzhou, China.

Characterization of the microbial community is essential for understanding the symbiotic relationships between microbes and host insects. Chrysomya megacephala is a vital resource, a forensic insect, a pollinator, and a vector for enteric bacteria, protozoa, helminths, and viruses. However, research on its microbial community is incomprehensive, particularly at the pupal stage, which comprises approximately half of the entire larval development stage and is important entomological evidence in forensic medicine. Read More

Front Pediatr 2021 20;9:805919. Epub 2022 Jan 20.

Department of Rheumatology, Umraniye Research and Training Hospital, University of Health Sciences, Istanbul, Turkey.

Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory disease manifesting phenotypic heterogeneity. It is a clinically diagnosed disease supported by gene mutation analysis. However, the phenotype-genotype correlation is not yet established clearly. Read More

Syst Rev 2022 02 1;11(1):18. Epub 2022 Feb 1.

Department of Plastic, Hand, and Reconstructive Microsurgery, BG-Trauma Hospital Frankfurt am Main, Frankfurt am Main, Germany.

Background: Lymphedema is a condition that affects up to 130 million subjects worldwide. Since it is related to several complications and a significant reduction in terms of quality of life, it is a heavy burden not only to the patients but also for the healthcare system worldwide. Despite the development of supermicrosurgery, such as vascularized lymph node transfer (VLNT) and lymphovenous anastomosis LVA, the indications and outcomes of these complex groups of interventions remain a controversial topic in the field of reconstructive plastic surgery. Read More

Funct Integr Genomics 2022 Jun 31;22(3):291-315. Epub 2022 Jan 31.

Department of Medical Genetics, Faculty of Medicine, Mersin University, Mersin, 33343, Turkey.

Familial Mediterranean fever (FMF) is a monogenic autoinflammatory disorder with recurrent fever, abdominal pain, serositis, articular manifestations, erysipelas-like erythema, and renal complications as its main features. Caused by the mutations in the MEditerranean FeVer (MEFV) gene, it mainly affects people of Mediterranean descent with a higher incidence in the Turkish, Jewish, Arabic, and Armenian populations. As our understanding of FMF improves, it becomes clearer that we are facing with a more complex picture of FMF with respect to its pathogenesis, penetrance, variant type (gain-of-function vs. Read More

Clin Rheumatol 2022 May 28;41(5):1535-1541. Epub 2022 Jan 28.

Department of Pediatric Rheumatology, Ankara University Faculty of Medicine, Ankara, Turkey.

Introduction: Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory disease that can present with various forms of arthritis. This retrospective study aims to evaluate the characteristics of patients with arthritis in a large pediatric cohort of FMF patients.

Methods: The demographic and clinical data were extracted from electronic medical records. Read More

Hautarzt 2022 Mar 27;73(3):223-233. Epub 2022 Jan 27.

Medizinische Fakultät und Uniklinik Köln, Klinik für Dermatologie und Venerologie, Universität zu Köln, Kerpener Str. 62, 50937, Köln, Deutschland.

Acute skin and soft tissue infections are among the most frequent infections in medicine. There is a broad spectrum including simple local infections as well as severe and life-threatening diseases. Along with Staphylococcus aureus, group A Streptococci are mainly responsible for these illnesses. Read More

Clin Case Rep 2022 Jan 20;10(1):e05248. Epub 2022 Jan 20.

Department of Dermatology Kuopio University Hospital and University of Eastern Finland Kuopio Finland.

A 54-year-old man developed a severe anaphylactic penicillin allergy after 16 years and 5 standard erysipelas treatments by intravenous benzylpenicillin and/or oral phenoxymethylpenicillin without any symptoms of allergy. It is recommended to analyze specific IgE antibodies for phenoxymethylpenicillin, benzylpenicillin, amoxicillin, and cefaclor to select an appropriate antibiotic. Read More

J Vet Diagn Invest 2022 Mar 25;34(2):268-272. Epub 2022 Jan 25.

U.S. Department of Agriculture, Animal Plant and Health Inspection Service, Veterinary Services, Harrisburg, PA, USA.

infection and septicemia occurred in a 5-d old Boer goat found dead on a farm in western Pennsylvania. On autopsy, there was moderate, focally extensive hemorrhage along the remnants of the urachus and umbilical arteries and the apex of the urinary bladder. Microscopic examination of immunohistochemical stained tissues revealed abundant intracellular and extracellular antigen-positive bacilli in all tissues stained, including lung, heart, liver, skeletal muscle, kidney, and thymus. Read More