2,628 results match your criteria Erysipelas


Giant cellulitis-like Sweet syndrome: An underrecognized clinical variant mimicking skin and soft tissue infection.

IDCases 2020 16;21:e00874. Epub 2020 Jun 16.

Department of Medicine, Mount Sinai Beth Israel, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

A new clinical variant of Sweet syndrome, called giant cellulitis-like Sweet syndrome, can masquerade as cellulitis because the patients present with an acute onset of large erythematous plaques, fever, and leukocytosis with neutrophil predominance. This case describes a 90-year-old female with a history of invasive ductal carcinoma of the breast who presented with 3 days of erythema of the right chest and right leg. Physical examination was notable for well-demarcated, blanching erythematous rashes involving the right chest and right lower extremity. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306609PMC

Suspected adverse reaction to erysipelas vaccine in sheep.

Vet Rec 2020 Jun;186(18):610-611

APHA, Weybridge, Woodham Lane, New Haw, Addlestone, Surrey KT15 3NB.

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http://dx.doi.org/10.1136/vr.m1482DOI Listing

Phase 1 Lymfactin Study: Short-term Safety of Combined Adenoviral VEGF-C and Lymph Node Transfer Treatment for Upper Extremity Lymphedema.

J Plast Reconstr Aesthet Surg 2020 May 18. Epub 2020 May 18.

Department of Plastic Surgery, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland. Electronic address:

Objective: To study the safety and tolerability of Lymfactin treatment combined with microvascular lymph node transfer surgery in patients with upper limb lymphedema.

Background: Upper limb lymphedema is a common clinical challenge after breast cancer surgery and/or radiotherapy. Lymfactin is an adenovirus type 5-based gene therapy involving expression of human vascular endothelial growth factor C (VEGF-C) in the damaged tissue. Read More

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http://dx.doi.org/10.1016/j.bjps.2020.05.009DOI Listing

Cutaneous leishmaniasis: A great imitator.

Clin Dermatol 2020 Mar - Apr;38(2):140-151. Epub 2019 Oct 24.

Department of Dermatology, Akdeniz University, School of Medicine, Antalya, Turkey.

Cutaneous leishmaniasis (CL) is called "the great imitator," because it can mimic almost all types of dermatoses. This similarity may sometimes lead to misdiagnosis, resulting in inappropriate treatment and morbidities. Atypical forms occur due to the interaction between parasitic factors and the host immune response. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2019.10.008DOI Listing
October 2019

Comparative Genome Analysis of a Pathogenic Isolate WH13013 from Pig Reveals Potential Genes Involve in Bacterial Adaptions and Pathogenesis.

Vet Sci 2020 Jun 4;7(2). Epub 2020 Jun 4.

State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, Hubei, China.

is a common pathogen responsible for pig erysipelas. However, the molecular basis for the pathogenesis of remains to be elucidated. In this study, the complete genome sequence of the strain WH13013, a pathogenic isolate from a diseased pig, was generated using a combined strategy of PacBio RSII and Illumina sequencing technologies. Read More

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http://dx.doi.org/10.3390/vetsci7020074DOI Listing

Erysipelas on surgical scar: a case report.

Pan Afr Med J 2020 7;35:30. Epub 2020 Feb 7.

Department of Gynecology and Obstetrics at the University Hospital of Monastir, Monastir, Tunisia.

Erysipelas is a non-necrotizing acute dermal hypodermatitis most often of streptococcal origin. It most often affects the lower limbs. Erysipelas on surgical scar has been rarely reported in the literature. Read More

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http://dx.doi.org/10.11604/pamj.2020.35.30.17551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245975PMC
February 2020

Influence of COVID-19 pandemic on hospitalizations at the tertiary dermatology department in south-west Poland.

Dermatol Ther 2020 Jun 1:e13738. Epub 2020 Jun 1.

Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland.

New virus SARS-Cov-2 infection has spread over the world affecting all daily activities, including functioning of health services. Due to pandemic, many hospitals were ordered to re-organize their work. The aim of the current report was to evaluate the influence of COVID-19 pandemic on the hospitalizations at the tertiary dermatology department in south-west Poland. Read More

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http://dx.doi.org/10.1111/dth.13738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300546PMC

In Search of Risk Factors for Recurrent Erysipelas and Cellulitis of the Lower Limb: A Cross-Sectional Study of Epidemiological Characteristics of Patients Hospitalized due to Skin and Soft-Tissue Infections.

Interdiscip Perspect Infect Dis 2020 7;2020:1307232. Epub 2020 May 7.

Department of Infectious and Tropical Diseases and Hepatology, Medical University of Warsaw, Hospital for Infectious Diseases, Warsaw, Poland.

Background: Erysipelas and cellulitis are common, acute, bacterial infections of the skin and subcutaneous tissue. The incidence of these infections is growing, and the recurrence rate is high. Effective antibiotic prophylaxis is available, but insufficient data exist on the risks factors for recurrent infection. Read More

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http://dx.doi.org/10.1155/2020/1307232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229562PMC

Repetitive cellulitis caused by isolates with different genotypic and phenotypic features in a patient having upper extremity with lymphedema after mastectomy and axillary lymph node dissection.

IDCases 2020 6;20:e00793. Epub 2020 May 6.

Laboratory of Infectious Diseases, Kitasato Institute for Life Sciences & Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan.

Previously reported cases of recurrent cellulitis/erysipelas affecting chronically lymphedematous skin regions have been demonstrated to be due to isolates with closely related genetic background which may be suggestive of relapse rather than reinfection. Herein, we report the occurrence of three episodes of repetitive cellulitis caused by strains with different genotypic and phenotypic characteristics, including different antimicrobial susceptibility patterns (tetracycline, macrolide/lincosamide, and fluoroquinolone classes), in the left upper extremity of a patient with lymphedema, following left mastectomy and axillary lymph node dissection. The genotypic and phenotypic characteristics of the three isolates were confirmed based on the random amplified polymorphic DNA patterns, DNA profiles of virulence factors (----), data on biofilm formation and cell invasion, antimicrobial susceptibility testing results, antimicrobial resistance (AMR) genotypes, and amino acid mutations associated with AMR. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218289PMC

Antibiotic prescribing among patients with severe infectious diseases in two private sector hospitals in Central India - a time series analysis over 10 years.

BMC Infect Dis 2020 May 13;20(1):340. Epub 2020 May 13.

Department of Global Public Health, Health Systems and Policy. Karolinska Institutet, SE-171 77, Stockholm, Sweden.

Background: Antibiotic resistance is an emerging problem caused due to antibiotic use. In countries with high rates of infectious diseases, antibiotic resistance is a frequent cause of mortality. The aim was to analyse antibiotic prescribing practices between 2008 and 2017 in a teaching (TH) and a non-teaching (NTH) hospital, as typical hospitals of low- and middle-income countries, and to compare antibiotic prescribing for severe infectious indications for which empiric antibiotic treatment is recommended. Read More

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http://dx.doi.org/10.1186/s12879-020-05059-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218632PMC

Calculated initial parenteral treatment of bacterial infections: Skin and soft tissue infections.

GMS Infect Dis 2020 26;8:Doc11. Epub 2020 Mar 26.

Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Frankfurt/Main, Germany.

This is the ninth chapter of the guideline "Calculated Parenteral Initial Therapy of Adult Bacterial Disorders - Update 2018" in the 2 updated version. The German guideline by the Paul-Ehrlich-Gesellschaft für Chemotherapie e.V. Read More

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http://dx.doi.org/10.3205/id000055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186924PMC

Spp.: Past, Present, and Future Directions in Vaccine Research.

Front Vet Sci 2020 15;7:174. Epub 2020 Apr 15.

National Institute of Animal Health, National Agriculture and Food Research Organization, Tsukuba, Japan.

spp. comprise a group of small Gram-positive bacteria that can infect a variety of hosts including mammals, fish, birds, reptiles and insects. Among the eight species that have been described to date, only plays a major role in farmed livestock where it is the causative agent of erysipelas. Read More

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http://dx.doi.org/10.3389/fvets.2020.00174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174600PMC

Lactoferrin: A Critical Mediator of Both Host Immune Response and Antimicrobial Activity in Response to Streptococcal Infections.

ACS Infect Dis 2020 May 7. Epub 2020 May 7.

Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.

Streptococcal species are Gram-positive bacteria responsible for a variety of disease outcomes including pneumonia, meningitis, endocarditis, erysipelas, necrotizing fasciitis, periodontitis, skin and soft tissue infections, chorioamnionitis, premature rupture of membranes, preterm birth, and neonatal sepsis. In response to streptococcal infections, the host innate immune system deploys a repertoire of antimicrobial and immune modulating molecules. One important molecule that is produced in response to streptococcal infections is lactoferrin. Read More

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http://dx.doi.org/10.1021/acsinfecdis.0c00050DOI Listing

[Indication of bloodletting therapy based on multi-dimensional evidence assessment].

Zhongguo Zhen Jiu 2020 Apr;40(4):450-4

Institute of Acupuncture and Moxibustion Standardization, Tianjin University of TCM, Tianjin 300193, China.

The indication of bloodletting therapy was determined based on the multi-dimensional evidence assessment, which could provide guidance for the clinical application of bloodletting therapy. The literature of bloodletting therapy was comprehensively collected by retrieval in CNKI, Wanfang and VIP databases (until February 23, 2019), modern books in Library of Tianjing University of TCM and the (Fifth Edition). The disease spectrum of bloodletting therapy was determined by self-designed questionnaire survey e-mailed to relevant experts. Read More

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http://dx.doi.org/10.13703/j.0255-2930.20190425-k0004DOI Listing

Erysipelas after Femoro-Tibial Bypass Surgery.

Vasc Specialist Int 2020 Mar;36(1):49-50

Division of Vascular Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

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http://dx.doi.org/10.5758/vsi.2020.36.1.49DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119151PMC

Development of a Multiplex PCR-Based Assay for Rapid Serotyping of Species.

J Clin Microbiol 2020 May 26;58(6). Epub 2020 May 26.

National Institute of Animal Health, National Agriculture and Food Research Organization, Tsukuba, Ibaraki, Japan.

The Gram-positive bacterium is a zoonotic pathogen that causes erysipelas in a wide range of mammalian and avian species. Historically, has been differentiated from other species by serotyping. Among 28 serovars of species, specific serovars, namely, 1a, 1b, and 2 of , are associated mainly with the disease in pigs, poultry, and humans; however, other serovar strains are often simultaneously isolated from diseased and healthy animals, indicating the importance of isolate serotyping for epidemiology. Read More

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http://dx.doi.org/10.1128/JCM.00315-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269376PMC

Milian's ear sign of erysipelas.

Postgrad Med J 2020 Jul 2;96(1137):446. Epub 2020 Apr 2.

Department of General Medicine, Chiba University Hospital, Chiba, Japan.

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http://dx.doi.org/10.1136/postgradmedj-2020-137713DOI Listing

Genomic and Immunogenic Protein Diversity of Isolated From Pigs in Great Britain: Implications for Vaccine Protection.

Front Microbiol 2020 13;11:418. Epub 2020 Mar 13.

The Roslin Institute, The University of Edinburgh, Midlothian, United Kingdom.

Erysipelas, caused by the bacterium , is re-emerging in swine and poultry production systems worldwide. While the global genomic diversity of this species has been characterized, how much of this genomic and functional diversity is maintained at smaller scales is unclear. Specifically, while several key immunogenic surface proteins have been identified for , little is known about their presence among field strains and their divergence from vaccines, which could result in vaccine failure. Read More

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http://dx.doi.org/10.3389/fmicb.2020.00418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083082PMC

The rash that presents as a red swollen face.

Clin Dermatol 2020 Jan - Feb;38(1):63-78. Epub 2019 Oct 23.

Dermatology Department, Coimbra University Hospital, Coimbra, Portugal; Clinic of Dermatology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal. Electronic address:

A red swollen face can be a skin sign of a potentially life-threatening condition. We present in detail the main clinical presentations, diagnostic tests, and management of some of the most severe conditions that can frequently present as a red and swollen face: acute or recurrent angioedema, mast cell-driven or bradykinin-mediated angioedema, nonhereditary and hereditary angioedema, allergic or photoallergic facial contact dermatitis, contact urticaria, severe adverse drug reactions (particularly drug reaction with eosinophilia and systemic symptoms [DRESS]), skin infections (erysipelas, cellulitis, necrotizing fasciitis), and autoimmune diseases (dermatomyositis). There are many other conditions that also have to be considered in the differential diagnosis of a red swollen face. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2019.10.017DOI Listing
October 2019

Flucloxacillin-Induced Hepatotoxicity - Association with HLA-B*5701.

Rev Assoc Med Bras (1992) 2020 27;66(1):12-17. Epub 2020 Feb 27.

. Hospital Assistant Physician Graduated on Internal Medicine, Tondela-Viseu Hospital Center, Viseu, Portugal.

Drug-induced liver injury (DILI) to flucloxacillin is rare and is classified as idiosyncratic, as it is dependent on individual susceptibility, unpredictable, and dose-independent. The authors present the case of a 74 - year - old man with a history of monoclonal gammopathy under investigation and alcoholic habits of 24 g/day, with asthenia, anorexia, nausea, abdominal discomfort, and fever with three days of evolution. He was treated with two courses of antibiotic therapy with flucloxacillin to erysipelas previously (3 months and 2 weeks before admission). Read More

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http://dx.doi.org/10.1590/1806-9282.66.1.12DOI Listing

Genome sequence of multidrug-resistant Erysipelothrix rhusiopathiae ZJ carrying several acquired antimicrobial resistance genes.

J Glob Antimicrob Resist 2020 Jun 28;21:13-15. Epub 2020 Feb 28.

Key Laboratory of Bio-Resources and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, and Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, Chengdu, Sichuan, PR China. Electronic address:

Objectives: This study aimed to determine the genetic environment of antimicrobial resistance genes (ARGs) in Erysipelothrix rhusiopathiae strain ZJ isolated from a pig with symptoms of swine erysipelas in China.

Methods: Illumina MiSeq (200× coverage) and PacBio RS II (100× coverage) platforms were used for genome sequencing. ARGs and prophages were identified using ResFinder 3. Read More

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http://dx.doi.org/10.1016/j.jgar.2020.02.017DOI Listing

Merkel cell carcinoma-derived Erysipelas carcinomatosum.

Dermatol Ther 2020 May 20;33(3):e13287. Epub 2020 Mar 20.

Department of Dermatology, University Medical Center, Johannes Gutenberg University, Mainz, Germany.

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http://dx.doi.org/10.1111/dth.13287DOI Listing

Erysipelas septicaemia in piglets born to vaccinated gilts.

Authors:

Vet Rec 2020 Feb;186(6):177-180

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http://dx.doi.org/10.1136/vr.m598DOI Listing
February 2020

Non-purulent skin and soft tissue infections: predictive power of a severity score and the appropriateness of treatment in a prospective cohort.

Infect Dis (Lond) 2020 May 13;52(5):361-371. Epub 2020 Feb 13.

Department of Medicine, Haukeland University Hospital, Bergen, Norway.

Skin and soft tissue infections (SSTIs) are increasing. Frequent over- and under-treatment has been reported, including non-purulent SSTIs where cases demanding surgery or broad-spectrum therapy often are hard to identify. Our aim was to measure the predictive power of a modified severity score and use it to identify areas of improvement in antimicrobial therapy of non-purulent SSTIs. Read More

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http://dx.doi.org/10.1080/23744235.2020.1726447DOI Listing

Association of Atopic Dermatitis With Bacterial, Fungal, Viral, and Sexually Transmitted Skin Infections.

Dermatitis 2020 Mar/Apr;31(2):157-164

Departments of Dermatology, Preventive Medicine and Medical Social Sciences, Northwestern University Feinberg School of Medicine.

Background: Atopic dermatitis (AD) is associated with altered skin barrier, microbiome, and immune dysregulation that may increase risk of skin infections.

Objective: The aim of the study was to determine whether AD is associated with skin infections and related outcomes.

Methods: Data from the 2006 to 2012 National Emergency Department Sample were analyzed, including an approximately 20% sample of all US emergency department (ED) visits (N = 198,102,435 adults or children). Read More

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http://dx.doi.org/10.1097/DER.0000000000000526DOI Listing
February 2020

Osteomyelitis complicating secondarily infected atopic eczema: two case reports and a narrative literature review.

BMC Dermatol 2020 02 3;20(1). Epub 2020 Feb 3.

Department of Dermatology, Nelson R Mandela School of Medicine, Private Bag X7, Congella, Durban, 4013, South Africa.

Background: Atopic eczema is a relapsing, itchy chronic cutaneous inflammatory disease that commonly affects children. The disease is often complicated by cutaneous infections such as eczema herpeticum, eczema vaccinatum and a varied number of bacterial infections - impetigo, cellulitis and erysipelas. However, rare case reports of infective endocarditis, otitis media and osteo-articular infections have been associated with atopic eczema. Read More

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http://dx.doi.org/10.1186/s12895-019-0098-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996158PMC
February 2020

Age of onset as an influencing factor for disease severity in children with familial Mediterranean fever.

Mod Rheumatol 2020 Jan 30:1-4. Epub 2020 Jan 30.

Department of Pediatric Rheumatology, Kanuni Sultan Süleyman Research and Training Hospital, University of Health Sciences, Istanbul, Turkey.

To define the demographic, clinical and genetic features of familial Mediterranean fever (FMF) patients with early disease onset and to compare them with late-onset FMF patients. Patients were divided into two groups according to the age of disease onset: group 1 includes the patients who had their first attack ≤3 years of age; group 2 consisted of patients who had their first attack >3 years of age. Furthermore, we compared the proportion of patients fulfilling the three diagnostic criteria among two groups. Read More

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http://dx.doi.org/10.1080/14397595.2020.1719594DOI Listing
January 2020

Erysipelas-like presentation of Wells' syndrome (eosinophilic cellulitis).

Reumatismo 2020 Jan 28;71(4):226-229. Epub 2020 Jan 28.

Department of Internal Medicine, Groupe Hospitalier Sud Ile de France, Melun.

Wells' syndrome, also called eosinophilic cellulitis, is a rare eosinophilic dermatosis characterized by an unspecific inflammatory erythematous eruption often associated with systemic symptoms. Here we report the case of a 57-year-old female with bilateral painful pitting and pruritic feet progressive for two weeks despite one week of oral antibiotics. Skin biopsy was performed showing dermal eosinophilic infiltration. Read More

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http://dx.doi.org/10.4081/reumatismo.2019.1252DOI Listing
January 2020

Skin Infections and Outpatient Burn Management: Bacterial Skin Infections.

FP Essent 2020 Feb;489:11-15

Maine-Dartmouth Family Medicine Residency, 15 East Chestnut St, Augusta, ME 04330.

Patients with bacterial skin and soft tissue infections (SSTIs) commonly present to family physicians. Common uncomplicated bacterial SSTIs include impetigo, ecthyma, cellulitis, erysipelas, abscesses, furuncles, and carbuncles. Risk factors for SSTIs include older age and chronic medical conditions, such as diabetes and cardiopulmonary or renal disease, and immunocompromise. Read More

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February 2020

A comprehensive molecular analysis and genotype-phenotype correlation in patients with familial mediterranean fever.

Mol Biol Rep 2020 Mar 27;47(3):1835-1843. Epub 2020 Jan 27.

Department of Medical Genetics, Haseki Training and Research Hospital, İstanbul, Turkey.

Familial Mediterranean fever is an auto inflammatory genetic disease involving especially Turks, Armenians, Arabs and non-Ashkenazi Jews and caused by variants in the MEFV gene. In this study, we aimed to evaluate the distribution and frequency of clinical, MEFV gene variants in FMF patients and the relationship between mutations in different exons and phenotype-genotype and clinical findings. 1028 patients diagnosed as FMF were included. Read More

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http://dx.doi.org/10.1007/s11033-020-05277-xDOI Listing

Comparison of Pediatric Familial Mediterranean Fever Patients Carrying Only E148Q Variant With the Ones Carrying Homozygous Pathogenic Mutations.

J Clin Rheumatol 2020 Jan 15. Epub 2020 Jan 15.

From the Department of Pediatric Rheumatology, University of Health Sciences, Kanuni Sultan Süleyman Research and Training Hospital, Istanbul, Turkey.

Objective: The aims of this study were to compare demographic data, clinical features, and severity scores of familial Mediterranean fever patients carrying E148Q variant with the patients having homozygous pathogenic MEFV mutations and to evaluate both of these groups for the performance of Tel-Hashomer, Livneh, and pediatric diagnostic criteria.

Methods: The demographic and clinical data of patients with familial Mediterranean fever either heterozygous or homozygous for E148Q variant (group 1) and patients with homozygous mutations (M694V, M694I, M680I, V726A) (group 2) were collected retrospectively. All patients were evaluated for 3 diagnostic criteria. Read More

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http://dx.doi.org/10.1097/RHU.0000000000001261DOI Listing
January 2020

Human Orf: An Under-recognized Entity.

Acta Dermatovenerol Croat 2019 Dec;27(4):280-281

Luis Santiago, MD, Dermatology Department Centro Hospitalar e Universitário de Coimbra, Praceta Prof. Mota Pinto, 3000-075 Coimbra, Portugal;

Dear Editor, Orf, also called contagious ecthyma, contagious pustular dermatitis, sore mouth, or scabby mouth, is a highly contagious zoonotic disease which is caused by a double-stranded DNA virus, ORFV (Parapoxvirus genus of the family Poxviridae) (1). The infection is endemic to sheep and goats, and humans are infected either through direct transmission from active lesions on infected animals or through contact with fomites (2). Orf is an occupational hazard and the population at risk includes shepherds, butchers, farmers, wool shearers, and veterinarians (2,3). Read More

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December 2019

Haemophilus parainfluenzae-related cellulitis of the penis following tearing of a short frenulum.

Ann Dermatol Venereol 2020 May 14;147(5):370-372. Epub 2020 Jan 14.

STI Unit, dermatology department, Saint Louis university hospital, 1, avenue Claude Vellefaux, 75010 Paris, France; The Infectious Dermatological Disease and Sexually Transmissible Infections group (GrIDIST), French Society of Dermatology, 10, cité Malerherbes, 75009 Paris, France.

Introduction: Infectious cellulitis is a common disease, mostly affecting the lower extremities and the face but only rarely the genitalia.

Observation: A 24-year-old male patient presented with acute erythematous edema of the penile shaft and foreskin present for 48hours. Gentle retraction of the foreskin revealed a short frenulum with a small area (2-3mm) of erosion. Read More

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http://dx.doi.org/10.1016/j.annder.2019.08.022DOI Listing

The Intriguing History of Cancer Immunotherapy.

Front Immunol 2019 17;10:2965. Epub 2019 Dec 17.

Chair and Department of Medical Microbiology, Medical University of Warsaw, Warsaw, Poland.

Immunotherapy is often perceived as a relatively recent advance. In reality, however, one should be looking for the beginnings of cancer immunotherapy under different names as far as in the Antiquity. The first scientific attempts to modulate patients' immune systems to cure cancer can be attributed to two German physicians, Fehleisen and Busch, who independently noticed significant tumor regression after erysipelas infection. Read More

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http://dx.doi.org/10.3389/fimmu.2019.02965DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928196PMC
December 2019

Dermatosis: Morbidity and mortality at the University Hospital Center of Brazzaville.

Med Sante Trop 2019 Nov;29(4):415-418

Service de dermatologie, CHU de Brazzaville, Université Marion Ngouabi, Faculté des Sciences de la Santé, 1 boulevard Maréchal Lyautey, BP : 32, Brazzaville, Congo.

To study the prevalence and distribution of dermatosis in hospitals and identify factors related to mortality and morbidity due to dermatosis Descriptive and analytical study conducted from 4 years of records of patients hospitalized in the department of dermatology of the University Hospital Center of Brazzaville. We identified 296 files of patients with dermatosis. The M/F ratio was 1. Read More

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http://dx.doi.org/10.1684/mst.2019.0931DOI Listing
November 2019

Is coverage of S. aureus necessary in cellulitis/erysipelas? A literature review.

Infection 2020 Apr 16;48(2):183-191. Epub 2019 Dec 16.

Infectious Diseases Unit, School of Medicine, University of Crete, Voutes, Heraklion, Postal code 71110, Greece.

Background: Empirical treatment of patients with cellulitis/erysipelas usually targets both streptococci and methicillin-sensitive S. aureus (MSSA). However, the recommendation to empirically cover MSSA is weak and based on low-quality evidence. Read More

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http://dx.doi.org/10.1007/s15010-019-01382-7DOI Listing

Prevalence of MEFV gene mutations in a large cohort of patients with suspected familial Mediterranean fever in Central Anatolia.

Ann Saudi Med 2019 Nov-Dec;39(6):382-387. Epub 2019 Dec 5.

From the Cumhuriyet University, Faculty of Medicine, Department of Medical Genetics, Sivas, Turkey.

Background: Familial Mediterranean fever (FMF), an autosomal recessive, autoinflammatory disease that is common in Arabs, Jews, Armenians and Turks, is caused by mutations in the MEFV gene, which encodes a protein called pyrin. The disease is characterised by recurrent fever, peritonitis, pleuritis, abdominal pain and arthralgia.

Objective: Determine the distributions of MEFV mutations and their relationship with clinical manifestations. Read More

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http://dx.doi.org/10.5144/0256-4947.2019.382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6894460PMC

A review of the antimicrobial potential of herbal drugs used in popular Italian medicine (1850s-1950s) to treat bacterial skin diseases.

J Ethnopharmacol 2020 Mar 29;250:112443. Epub 2019 Nov 29.

Institute for Agricultural and Forest Systems in the Mediterranean, National Research Council, Via Cavour 4-6, 87036, Rende, CS, Italy. Electronic address:

Ethnopharmacological Relevance: Before the advent of modern antibiotics, microbial infections were treated with herbal medicine or cauterization. Literature from the latter half of the nineteenth to the early mid-twentieth century, when antibiotics became widely available, arguably holds the most progressive information about herbal remedies to treat bacterial skin diseases. The corpus of literature produced in Italy during that period is not easily accessible and mostly out of print. Read More

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http://dx.doi.org/10.1016/j.jep.2019.112443DOI Listing

A putative transcription regulator involved in the virulence attenuation of an acriflavine-resistant vaccine strain of Erysipelothrix rhusiopathiae, the causative agent of swine erysipelas.

Vet Microbiol 2019 Dec 1;239:108488. Epub 2019 Nov 1.

National Institute of Animal Health, National Agriculture and Food Research Organization (NARO), 3-1-5 Kannondai, Tsukuba, Ibaraki, 305-0856, Japan.

Acriflavine, an acridine dye that causes frameshift mutations, has been used to attenuate various veterinary pathogens for the development of live vaccines. Erysipelothrix rhusiopathiae Koganei 65-0.15 strain (Koganei) (serovar 1a) is the acriflavine-resistant live vaccine currently used in Japan for the control of swine erysipelas. Read More

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http://dx.doi.org/10.1016/j.vetmic.2019.108488DOI Listing
December 2019

Impact of a Live Attenuated Classical Swine Fever Virus Introduced to Jeju Island, a CSF-Free Area.

Pathogens 2019 Nov 20;8(4). Epub 2019 Nov 20.

Viral Disease Division, Animal and Plant Quarantine Agency (APQA), Gimcheon, Gyeongbuk 39660, Korea.

Here, we examine the effects of LOM(Low virulence of Miyagi) strains isolated from pigs (Jeju LOM strains) of Jeju Island, where vaccination with a live attenuated classical swine fever (CSF) LOM vaccine strain was stopped. The circulation of the Jeju LOM strains was mainly caused by a commercial swine erysipelas (Erysipelothrix rhusiopathiae) vaccine mixed with a LOM vaccine strain, which was inoculated into pregnant sows of 20 pig farms in 2014. The Jeju LOM strain was transmitted to 91 pig farms from 2015 to 2018. Read More

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http://dx.doi.org/10.3390/pathogens8040251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963429PMC
November 2019

[Erysipelas associated with recurrent squamous cell carcinoma of the labium majus after radiochemotherapy].

Pan Afr Med J 2019 23;33:248. Epub 2019 Jul 23.

Service de Dermatologie et Vénérologie, Hôpital Universitaire Hassan II, Fès, Maroc.

The erysipelas is a bacterial infection most frequently due to (85% of cases) streptococcus β-hemolytic of group A (SGA), resulting in non-necrotizing dermo-hypodermitis. Many factors may play a role in its occurrence such as general factors: diabetes, immunosuppression, chemotherapy, radiotherapy as well as locoregional ports of entry such as leg ulcer, an insect bite, intertrigo. The occurrence of erysipelas associated with recurrent squamous cell carcinoma after radiochemotherapy is exceptional, requiring early treatment of dermo-hypodermitis as well as suitable and multidisciplinary management of the carcinoma. Read More

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http://dx.doi.org/10.11604/pamj.2019.33.248.16771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814916PMC
November 2019

Erysipelothrix Septicaemia and Hepatitis in a Colony of Humboldt Penguins (Spheniscus humboldti).

J Comp Pathol 2019 Oct 17;172:5-10. Epub 2019 Sep 17.

Centre for Animal and Veterinary Sciences, National Parks Board, 1 Cluny Road, Singapore.

This report describes an outbreak of erysipelas in a colony of captive Humboldt penguins (Spheniscus humboldti). The only previously reported case in a related species was of an individual little blue penguin (Eudyptula minor). Five Humboldt penguins in a mixed colony displayed non-specific signs of illness, including lethargy, inappetence and regurgitation after movement for exhibit upgrading. Read More

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http://dx.doi.org/10.1016/j.jcpa.2019.08.004DOI Listing
October 2019
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Management and biosecurity practices on pig farms in the Western Highlands of Cameroon (Central Africa).

Vet Med Sci 2020 02 4;6(1):82-91. Epub 2019 Nov 4.

Department of Animal Production, Faculty of Agronomy and Agricultural Sciences, Dschang, Cameroon.

African swine fever (ASF), erysipelas and many other infectious and parasitic diseases have seriously compromised the future of pig industry in the Western Highlands of Cameroon. Since implementation of biosecurity measures (BM) is known to reduce the risk of disease transmission, the objective of this study was to describe the pig farming management system as well as the biosecurity practices on pig farms in the Western Highlands of Cameroon. Therefore, 97 farms were investigated using a face-to-face interview-based questionnaire. Read More

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http://dx.doi.org/10.1002/vms3.211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036310PMC
February 2020

Lessons Learned From a Randomized Controlled Trial of Short-Course Intravenous Antibiotic Therapy for Erysipelas and Cellulitis of the Lower Limb (Switch Trial).

Open Forum Infect Dis 2019 Sep 20;6(9):ofz335. Epub 2019 Jul 20.

Department of Infectious Diseases, Barwon Health, Geelong, Victoria, Australia.

Background: The diagnosis of cellulitis is made clinically without a gold standard diagnostic test, and cellulitis has many disease mimics. There is currently no consensus for optimal antimicrobial treatment duration or method of antimicrobial delivery.

Methods: This was a randomized controlled open-label multicenter trial to determine the safety and efficacy of 24 hours of intravenous (IV) therapy compared with ≥72 hours of IV therapy, both followed by oral therapy to a maximum of 7-10 days' duration for the treatment of lower limb cellulitis. Read More

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http://dx.doi.org/10.1093/ofid/ofz335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6798252PMC
September 2019
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[Characteristics of chronic wounds in substance abuse: A retrospective study of 58 patients].

Ann Dermatol Venereol 2019 Dec 21;146(12):793-800. Epub 2019 Oct 21.

Service de dermatologie, CHR de Metz-Thionville, rue du Friscaty, 57100 Thionville, France.

Background: Drug addiction causes chronic wounds (CW) responsible for severe complications. Very few studies are available on this topic. The aim of our study was to describe the demographic, clinical and etiological characteristics as well as the course of CW in drug addicts. Read More

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http://dx.doi.org/10.1016/j.annder.2019.09.004DOI Listing
December 2019
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Diagnostic Value of Laboratory Parameters for Distinguishing Between Herpes Zoster and Bacterial Superficial Skin and Soft Tissue Infections.

Acta Derm Venereol 2020 01 7;100(1):adv00009. Epub 2020 Jan 7.

Department of Dermatology, University of Münster, Münster, Germany.

Clinical differentiation between herpes zoster and bacterial superficial skin and soft tissue infections of the face can be difficult. In addition, diagnosis can be complicated by bacterial superinfection of lesional herpes zoster. The aim of this study was to determine whether inflammatory parameters, such as C-reactive protein (CRP) and blood counts, might be reliable biomarkers to distinguish between skin and soft tissue infections and herpes zoster when the face is infected. Read More

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http://dx.doi.org/10.2340/00015555-3357DOI Listing
January 2020

Molecular Profiling of EGFR Status to Identify Skin Toxicity in Colorectal Cancer: A Clinicopathological Review.

Curr Health Sci J 2019 Apr-Jun;45(2):127-133. Epub 2019 Jun 30.

Gastro Unit, Division of Endoscopy, Copenhagen University Hospital Herlev, Denmark.

Colorectal cancer (CRC) represents an important health problem, being the third most common type of cancer. In Romania, the CRC incidence has doubled over the years. Both environmental factors and genetic susceptibility are very important for the pathogenesis of CRC. Read More

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http://dx.doi.org/10.12865/CHSJ.45.02.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778291PMC
June 2019
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The influence of genotype on disease severity and concomitant diseases in familial Mediterranean fever patients.

Clin Exp Rheumatol 2019 Nov-Dec;37 Suppl 121(6):93-97. Epub 2019 Oct 10.

Division of Rheumatology, Eskişehir Osmangazi University, Eskişehir, Turkey.

Objectives: To evaluate differences between the patients with familial Mediterranean fever (FMF) with homozygous (Hom), heterozygous (Het) and compound heterozygous (cHet) MEFV mutations in terms of clinical features and severity of the disease, as well as frequency of concomitant disorders, without focusing on Exon 10 mutations.

Methods: The patients with FMF were diagnosed using the Tel-Hashomer diagnostic criteria. The presence of MEFV mutations was investigated in exons 2,3,5 and 10 by multiplex-PCR reverse hybridisation method. Read More

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January 2020
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Vasculitis Mimicking Pseudo Erysipelas in Systemic Lupus Erythematosus.

Acta Derm Venereol 2019 Dec;99(13):1295-1296

Department of Dermatology, Saint Louis Hospital, , France.

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http://dx.doi.org/10.2340/00015555-3334DOI Listing
December 2019
2 Reads