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    1 OF 49

    Lymph Drainage of Posttraumatic Edema of Lower Limbs.
    Case Rep Orthop 2018 5;2018:7236372. Epub 2018 Mar 5.
    Cardiovascular Surgery Department, The Medicine School in São José do Rio Preto (FAMERP) and CNPq (National Council for Research and Development), São Jose do Rio Preto, SP, Brazil.
    Objective: The present study was aimed at evaluating the use of mechanical and manual lymphatic therapy as a treatment for lymphedema resulting from orthopedic surgery that became painful after an episode of erysipelas.

    Case Report: A 70-year-old male patient suffered direct trauma resulting in a compound fracture of the tibia and fibula of the left leg. He was treated with an external fixator for four months followed by plaster cast immobilization for three weeks. Read More

    [Shewanella algae bacteriaemia after a vacation in Thailand].
    Ugeskr Laeger 2018 Apr;180(15)
    This is a case report of a 56-year-old man, who presented with a very rare cause of erysipelas and bacteraemia caused by the Gram-negative bacillus Shewanella algae. To our knowledge, this is the first reported case of imported Shewanella-infection in Denmark. The patient, who had a history of liver cirrhosis, returned home from a one-month vacation in Thailand. Read More

    Safety profile of chronic leg ulcer biopsy: a monocentric retrospective series on 866 patients.
    G Ital Dermatol Venereol 2018 Apr 19. Epub 2018 Apr 19.
    Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
    Background: Skin biopsy is an important tool for various skin conditions. However, in the case of leg ulcers, some Authors still consider it highly risky and mandatory only in selected cases.

    Methods: To evaluate the rate of adverse events after leg ulcers biopsy in 866 consecutive patients referring to our Wound Care Unit in Bologna from January 2008 to December 2016. Read More

    Breast cancer cutaneous metastases mimicking Papilloma Cutis Lymphostatica. Biopsy to avoid pitfalls.
    Int J Surg Case Rep 2018 Apr 10;46:31-33. Epub 2018 Apr 10.
    Department of Plastic and Reconstructive Surgery, University of Bari, Italy.
    Introduction: Secondary lymphedema is the most frequent long-term complication of axillary lymphadenectomy. It can result in complication as erysipelas, warts, Papilloma Cutis Lymphostatica (PCL), or angiosarcomas. Moreover, in women affected by breast cancer an accurate differential diagnosis among these conditions or complication related to radiation dermatitis or cutaneous metastasis is essential. Read More

    Trends in the epidemiology of erysipelas in Slovenia.
    Acta Dermatovenerol Alp Pannonica Adriat 2018 03;27(1):1-4
    Centre for Communicable Diseases, National Institute of Public Health, Ljubljana, Slovenia.
    Introduction: Erysipelas is a common infection of the skin and subcutaneous tissue. Despite the relative frequency of erysipelas, data on its basic epidemiological characteristics are scant. This study describes the trends in erysipelas epidemiology in Slovenia. Read More

    Cutaneous infections in the mature patient.
    Clin Dermatol 2018 Mar - Apr;36(2):188-196. Epub 2017 Oct 3.
    Sector of Dermatology and Post-Graduation Course in Dermatology, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address:
    Dermatologists must be familiar with the peculiarities of the micro-organisms that may affect the elderly, in order to optimize the diagnosis and treatment of infections, which may affect their skin, especially because the world population is rapidly aging. It is estimated that there will be 434 million individuals over 80 years of age in 2050. Since the elderly population is rapidly increasing and their infections are usually more severe and different from those observed in younger adults, it leads to a statistical increase of the rates regarding hospitalization and mortality caused by infectious diseases among people over 85 years. Read More

    Corticosteroid Therapy in Combination with Antibiotics for Erysipelas.
    Isr Med Assoc J 2018 Mar;20(3):137-140
    Department of Dermatology, Sheba Medical Center, Tel Hashomer, affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
    Background: Erysipelas, an acute infection of the dermal and subcutaneous tissue, is normally treated with antibiotics. Previous data indicated that treatment with prednisone in combination with antibiotics results in significant acceleration of the healing phase.

    Objectives: To investigate the effectiveness of corticosteroids combined with antibiotics for the treatment of erysipelas. Read More

    Recurrent erysipelas of the face with hyperimmune reaction to group C streptococcus.
    Br J Dermatol 2018 Mar 11. Epub 2018 Mar 11.
    Dermatology Department, University Hospital of Bordeaux, Bordeaux, France.
    We present the case of a 73-year-old-woman, admitted in 2014 for n erysipelas of the face (figure 1a) beginning 3 days before, with red oedematous papules of the left temple, hyperthermia and chills the day after. Clinical examination did not find lymphadenopathy or skin lesion especially at her left ear. Blood samples showed a raised C reactive protein (CRP) to 120 mg/L without leukocytosis. Read More

    INDEXES OF CYTOKINE PROFILE OF BLOOD IN PATIENTS WITH COMPLICATED ERYSIPELAS.
    Georgian Med News 2018 Jan(274):13-18
    State Establishment "Lugansk State Medical University", Rubizhne, Lugansk region, Ukraine.
    The cytokine blood profile in patients with complicated erysipelas was investigated. It was found that in patients with complications of erysipelas (gangrene, phlegmon, abscess, thrombophlebitis of the subcutaneous veins of the shin) levels of pro-inflammatory cytokines IL-1ß, TNF-α, IL-2, IL-6 in serum significantly increase and level of anti-inflammatory cytokine IL-4 increases slightly, as well as was found a significant increase in coefficients reflecting the ratio of pro-inflammatory and anti-inflammatory cytokines, which indicates the prevalence in the blood of examined patients with complications of erysipelas an anti-inflammatory properties. A more significant increase in pro-inflammatory cytokines serum levels is typical for patients with destructive forms of erysipelas - phlegmonous and gangrenous, a slight increase - for patients without purulent-necrotic component of complication (thrombophlebitis of the subcutaneous veins of the shin). Read More

    Influence of alternative husbandry systems on postmortem findings and prevalence of important bacteria and parasites in layers monitored from end of rearing until slaughter.
    Vet Rec 2018 03 6;182(12):350. Epub 2018 Feb 6.
    Department for Farm Animals and Veterinary Public Health, Clinic for Poultry and Fish Medicine, University of Veterinary Medicine Vienna, Vienna, Austria.
    In the present study 66 layer flocks housed in different alternative husbandry systems were monitored from placement of birds on the farm until slaughter to evaluate a possible influence on the occurrence of selected non-infectious as well as infectious diseases. Postmortems were performed and the occurrence of extraintestinal and was investigated. No specific postmortem findings were seen in pullets. Read More

    Severe lower limb cellulitis: defining the epidemiology and risk factors for primary episodes in a population-based case-control study.
    Clin Microbiol Infect 2018 Feb 7. Epub 2018 Feb 7.
    Infectious Diseases Department, Fiona Stanley Hospital, Perth, Western Australia, Australia; School of Medicine and Pharmacology, University of Western Australia, Harry Perkins Research Institute, Fiona Stanley Hospital, Murdoch, Western Australia, Australia. Electronic address:
    Objective: To describe the epidemiology and risk factors for primary episodes of severe lower leg cellulitis (LLC).

    Methods: This was a longitudinal cohort study using state-wide data linkage of adults presenting to Western Australian (WA) hospitals with a first ever LLC from January 2002 to December 2013. The study aimed at determining risk factors, medical records from the index patient, together with comparable data from controls matched by age, sex, postcode, and month of admission. Read More

    [The conspicuous leg].
    Internist (Berl) 2018 Mar;59(3):227-233
    Medizinische Klinik 2, Städtisches Klinikum Dresden, Friedrichstr. 41, 01067, Dresden, Deutschland.
    Symptoms of the leg or of both legs, may indicate a need for evaluation and/or treatment, which must be clarified urgently or even as an emergency situation. Among the diseases which must be considered from a vascular viewpoint are critical limb ischemia, suspicion of deep leg vein thrombosis and special forms of venous insufficiency. With respect to infections erysipelas and the syndrome of infected diabetic foot must be considered as well as peripheral and central leg paresis as orthopedic and neurological disorders, respectively. Read More

    Cutaneous hemophagocytosis: Clinicopathologic features of 21 cases.
    J Am Acad Dermatol 2018 Feb;78(2):377-382
    Research Unit Dermatopathology, Department of Dermatology, Medical University of Graz, Graz, Austria. Electronic address:
    Background: Hemophagocytosis is well known in cytotoxic cutaneous T-cell lymphomas (CTCLs), in which it may represent a sign of hemophagocytic lymphohistiocytosis syndrome (HLHS), and is also typical of cutaneous Rosai-Dorfman disease (cRDD) (without prognostic relevance). Only rarely, has cutaneous hemophagocytosis (CH) been described in other skin conditions.

    Objective: To characterize the clinicopathologic features of CH in skin biopsy specimens from patients with conditions other than CTCL or cRDD. Read More

    Comparison of early versus late onset familial Mediterranean fever.
    Int J Rheum Dis 2018 Apr 5;21(4):880-884. Epub 2018 Jan 5.
    Division of Rheumatology, Department of Internal Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey.
    Aim: Familial Mediterranean fever (FMF) is the most common autoinflammatory disease. One of the common characteristics of this disease is its young age predominance. Nearly 90% of patients experience disease flares during early adult age periods. Read More

    Clinical Guidelines for the Antibiotic Treatment for Community-Acquired Skin and Soft Tissue Infection.
    Infect Chemother 2017 Dec;49(4):301-325
    Department of Internal Medicine, Inje University Ilsan Paik Hospital, Goyang, Korea.
    Skin and soft tissue infection (SSTI) is common and important infectious disease. This work represents an update to 2012 Korean guideline for SSTI. The present guideline was developed by the adaptation method. Read More

    Association between atopic dermatitis and serious cutaneous, multiorgan and systemic infections in US adults.
    Ann Allergy Asthma Immunol 2018 Jan;120(1):66-72.e11
    Departments of Dermatology, Preventive Medicine and Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Northwestern Medicine Multidisciplinary Eczema Center, Chicago, Illinois. Electronic address:
    Background: Atopic dermatitis (AD) is associated with barrier disruption, immune dysregulation, and immunosuppressing treatments that can increase the association with an unusual number of infections.

    Objective: To determine whether adults with AD have an unusually large number of serious infections and related outcomes.

    Methods: Data from the 2002 to 2012 National Inpatient Sample were analyzed, including an approximately 20% sample of all US hospitalizations (n = 72,108,077 adults). Read More

    Which outcomes are reported in cellulitis trials? Results of a review of outcomes included in cellulitis trials and a patient priority setting survey.
    Br J Dermatol 2017 Dec 9. Epub 2017 Dec 9.
    Centre of Evidence Based Dermatology, The University of Nottingham, Nottingham, U.K.
    Background: There is an emerging need to develop consistent outcomes in clinical trials to allow effective comparison of treatment effects. No systematic review has previously looked at the reporting of outcome measures used in randomized controlled trials (RCTs) on the treatment and prevention of cellulitis (erysipelas).

    Objectives: The primary aim of this review was to describe the breadth of outcomes reported from RCTs on cellulitis treatment and prevention. Read More

    Characterization of pathogenic roles of two Erysipelothrix rhusiopathiae surface proteins.
    Microb Pathog 2018 Jan 28;114:166-168. Epub 2017 Nov 28.
    Animal Infectious Disease Unit, National State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China; College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China; Key Laboratory of Development of Veterinary Diagnostic Products, Ministry of Agriculture, Wuhan, China; Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China. Electronic address:
    Erysipelothrix rhusiopathiae is the causative agent of animal erysipelas and human erysipeloid. E. rhusiopathiae HP0728 and HP1472 have been reported to be down regulated in low-virulence or avirulent strains, but their pathogenic roles are not known. Read More

    [Charcot foot masked by erysipelas and peripheral arterial disease].
    Hautarzt 2018 Apr;69(4):316-320
    Klinik für Dermatologie, Klinikum Dortmund gGmbH, Beurhausstr. 26, 44137, Dortmund, Deutschland.
    Charcot foot is also known as Charcot disease or Charcot arthropathy. The associated aseptic destruction of the bones and joints of the foot results due to peripheral neuropathy accompanied by impaired pain perception, impaired vasomotricity with increased vasodilation, and an unequal weight distribution. Because it is frequently diagnosed late and, thus, incorrectly treated, serious complications often result. Read More

    Cutaneous metastases of internal malignancies: an experience from a single institution.
    Eur J Dermatol 2017 Dec;27(6):609-614
    Unità Operativa di Anatomia Patologica, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, via Francesco Sforza 35, 20122 Milan, Italy.
    Background: Cutaneous metastases represent 2% of all skin tumours. Their recognition can be challenging, as they may present with different clinical features, with consequent frequent delay and failure in diagnosis.

    Objectives: To review our series of cutaneous metastatic lesions, analyse their frequency according to patient gender, histotype, localization of the primary tumour, and site of cutaneous metastasis, and correlate this data with clinicopathological parameters. Read More

    Soft-tissue infection secondary to cellulitis killed St. John of the Cross (1542-1591).
    Infection 2018 Apr 31;46(2):267-269. Epub 2017 Oct 31.
    Department of Medicine, "San Giovanni di Dio" Hospital, Gorizia, Italy.
    Purpose: St. John of the Cross (1542-1591) died aged 49 years after 3 months of excruciating pain following a trivial lesion in his right foot. Erysipelas, a superficial bacterial infection of the skin, and subsequent sepsis were previously suggested as the cause of his death. Read More

    Genotype-phenotype correlation in FMF patients: A "non classic" recessive autosomal or "atypical" dominant autosomal inheritance?
    Gene 2018 Jan 6;641:279-286. Epub 2017 Nov 6.
    Department of Pediatrics, Unit of Pediatric Genetics and Immunology, University of Messina, Messina, Italy.
    Background: Uncertainty remains on the pathogenetic mechanisms, model of inheritance as well as genotype-phenotype correlation of FMF disease.

    Objective: To investigate the impact of genetic factors on the FMF phenotype and the disease inheritance model.

    Methods: A total of 107 FMF patients were enrolled. Read More

    Clinical Mimics: An Emergency Medicine-Focused Review of Cellulitis Mimics.
    J Emerg Med 2017 Oct;53(4):475-484
    Department of Emergency Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas.
    Background: Cellulitis is a common clinical condition with low rates of morbidity and mortality if treated appropriately. Mimics of cellulitis presenting with erythema, edema, warmth, and pain can be associated with grave morbidity and mortality if misdiagnosed.

    Objective: This review investigates the signs and symptoms of cellulitis, mimics of cellulitis, and an approach to the management of both cellulitis and its mimics. Read More

    Characterization of roles of SpaA in Erysipelothrix rhusiopathiae adhesion to porcine endothelial cells.
    Microb Pathog 2017 Dec 14;113:176-180. Epub 2017 Oct 14.
    Animal Infectious Disease Unit, National State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China; College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China; Key Laboratory of Development of Veterinary Diagnostic Products, Ministry of Agriculture, Wuhan, China; Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China. Electronic address:
    Erysipelothrix rhusiopathiae is the causative agent of animal erysipelas and human erysipeloid. The major protective antigen SpaA was suggested to play important roles in E. rhusiopathiae adhesion to host cells, but there is no specific study on SpaA pathogenic roles in adhesion. Read More

    An unusual cutaneous infection caused by .
    JMM Case Rep 2017 Apr 12;4(4):e005088. Epub 2017 Apr 12.
    Department of Health Science, University of Eastern Piedmont, Novara, Italy.
    is a non-tubercular mycobacterium residing in fresh or salt water (in tropical or temperate areas); it is a fish and human pathogen, and in immunocompromised patients can cause severe cutaneous and subcutaneous infections. A 46-year-old white man who underwent immunosuppressive therapy was admitted to our department in May 2016 for skin lesions previously diagnosed as 'unusual erysipelas'. We rejected the hypothesis of erysipelas, due to the clinical features, and our diagnostic hypotheses were oriented towards sporotrichosis, atypical mycobacteriosis, cutaneous tuberculosis and cutaneous sarcoidosis. Read More

    [Compression is important in erysipelas treatment].
    Ugeskr Laeger 2017 Oct;179(41)
    Erysipelas is a common skin infection involving the lymphatic vessels, which induces an oedema. This has a tendency of persisting after infection is treated. The lymphatic system plays an important role in the immune system, and the impaired lymph drainage leads to a state of local immune deficiency. Read More

    Transcription analysis of the responses of porcine heart to Erysipelothrix rhusiopathiae.
    PLoS One 2017 4;12(10):e0185548. Epub 2017 Oct 4.
    Unit of Animal Infectious Diseases, State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei, P.R. China.
    Erysipelothrix rhusiopathiae (E. rhusiopathiae) is the causative agent of swine erysipelas. This microbe has caused great economic losses in China and in other countries. Read More

    Ventral Abdominal Hernia.
    Open Access Maced J Med Sci 2017 Aug 10;5(5):694-695. Epub 2017 Aug 10.
    University of Rome " G.Marconi", Rome, Italy.
    A 63-year-old Caucasian female patient presented with redness of the both foot and lower legs, as well as edema of the left lower leg, accompanied by subjective complaints of burning. Fever was not reported. Well-circumscribed oval shaped tumor formation was revealed also on the abdominal wall, with hyperpigmented and depigmented areas on its ulcerated surface, measuring approximately 10/10cm in diameter, with soft-elastic texture on palpation. Read More

    Phytochemistry, pharmacology, quality control and future research of Forsythia suspensa (Thunb.) Vahl: A review.
    J Ethnopharmacol 2018 Jan 5;210:318-339. Epub 2017 Sep 5.
    Beijing Key Lab for Quality Evaluation of Chinese Materia Medica, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China. Electronic address:
    Ethnopharmacological Relevance: Forsythiae Fructus (called Lianqiao in Chinese), the fruit of Forsythia suspensa (Thunb.) Vahl, is utilized as a common traditional medicine in China, Japan and Korea. It is traditionally used to treat pyrexia, inflammation, gonorrhea, carbuncle and erysipelas. Read More

    [Bacterial skin and soft tissue infections].
    Z Rheumatol 2017 Nov;76(9):745-751
    Interdisziplinäre Notaufnahme und Stabsstelle Infektiologie, Universitätsklinikum Regensburg, Franz-Josef-Strauß-Allee 11, 93043, Regensburg, Deutschland.
    Bacterial skin and soft tissue infections are frequent and represent one of the most important differential diagnoses in patients presenting with reddened and swollen skin and soft tissue. Among these infections, cellulitis (phlegmon), erysipelas and abscesses are the most frequent. Whereas erysipelas is almost exclusively caused by streptococci and can be successfully treated with penicillin, an effective antibiotic therapy targeted at Staphylococcus aureus should be empirically considered for abscesses and phlegmon; other pathogens, such as gram negative and anaerobic bacteria can be found in patients with the corresponding underlying disease and certain risk factors. Read More

    Cutaneous infection and bactaeremia caused by : a case report.
    New Microbes New Infect 2017 Sep 23;19:134-136. Epub 2017 Jul 23.
    Infectious Diseases Department, Riviera-Chablais Hospital, Montreux, Switzerland.
    Cellulitis and erysipelas are common skin infections usually caused by and streptococci. Gram-negative rods are rarely implicated. We report here a case of dermohypodermitis and bactaeremia caused by , a Gram-negative bacteria usually pathogenic and epiphytic to pome fruit tree. Read More

    Hereditary Lymphedema of the Leg - A Case Report.
    Open Access Maced J Med Sci 2017 Jul 19;5(4):451-453. Epub 2017 Jul 19.
    Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Friedrichstrasse 41, 01067, Dresden, Germany.
    Primary of hereditary lymphedema is a rare but progressive disease. It is yet not curable. We present a 48-year-old male patient with hereditary lymphedema of his left leg, that was realised by minor trauma (able twist) when he was seven years old. Read More

    Aetiology and clinical features of facial cellulitis: a prospective study.
    Infect Dis (Lond) 2018 Jan 2;50(1):27-34. Epub 2017 Aug 2.
    a Department of Clinical Science , University of Bergen , Bergen , Norway.
    Background: In the early 20th century, the face was the predominant site of cellulitis. Despite a relative decrease in the incidence of facial cellulitis, it is still common. There are few studies on this condition during the last decades. Read More

    [Primary congenital lymphedema: Milroy disease: the first case observed in the Department of Pediatrics at the University Hospital Yalgado Ouedraogo, Ouagadougou].
    Pan Afr Med J 2017 9;27:21. Epub 2017 May 9.
    Département de Pédiatrie du CHU Yalgado Ouédraogo de Ouagadougou, Burkina-faso.
    Congenital lymphedema is the accumulation of lymphatic fluid in the child's interstitial spaces. Milroy disease is a rare, hereditary, autosomal dominant condition showing incomplete penetrance. We report the case of a 7-year old little girl with Milroy disease examined for erysipelas on congenital big right leg. Read More

    Pitfall of modern genetics: recurrent erysipelas masquerading as autoinflammatory disease.
    Neth J Med 2017 Jul;75(6):247-249
    Department of Internal Medicine, Radboud University Medical Centre, Nijmegen, the Netherlands.
    A patient presented with recurrent episodes of fever and skin rash for eight years. DNA analysis of the NLRP3 gene revealed a mutation associated with autoinflammatory disease. After an initial positive response to the biological anakinra, the patient deteriorated. Read More

    Tc-99m-Human Serum Albumin Transit Time as a Measure of Arm Breast Cancer-Related Lymphedema.
    Plast Reconstr Surg Glob Open 2017 Jun 13;5(6):e1362. Epub 2017 Jun 13.
    Department of Plastic and Reconstructive Surgery, Odense University Hospital, Odense C, Denmark; Department of Clinical Research, University of Southern Denmark, Odense C, Denmark; and Department of Nuclear Medicine, Odense University Hospital, Odense C, Denmark.
    Background: Lymphoscintigraphy has often been used for evaluating arm lymphatic dysfunction, but no optimal approach for quantification has so far emerged. We propose a quantifiable measure of lymphatic function that we applied in patients treated for breast cancer.

    Methods: Eleven patients, aged 34-68 years, with unilateral arm lymphedema following breast cancer treatment underwent bilateral lymphoscintigraphy using intradermal injection in both hands of technetium-99m-labeled human serum albumin and sequential 5 min imaging for 5 hours. Read More

    Skin and soft tissue infections, active component, U.S. Armed Forces, 2013-2016.
    MSMR 2017 Jul;24(7):2-11
    During the 4-year surveillance period, there were 282,571 incident cases of skin and soft tissue infection (SSTI) among active component U.S. military members diagnosed in inpatient or outpatient settings, corresponding to an overall incidence of 558. Read More

    Cost-of-illness of patients with lymphoedema.
    J Eur Acad Dermatol Venereol 2017 Nov 10;31(11):1930-1935. Epub 2017 Oct 10.
    Institute for Health Services Research in Dermatology and Nursing (IVDP), German Center for Health Services Research in Dermatology (CVderm), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
    Background: Chronic lymphoedema is characterized by a continuous need for medical treatment, many comorbidities and impaired quality of life. In Germany, about 4.5 million patients are affected by lymphoedema. Read More

    [Primary lymphedema in childhood].
    Arch Pediatr 2017 Aug 23;24(8):766-776. Epub 2017 Jun 23.
    Service de dermatologie, hôpital Necker, AP-HP, 149, rue de Sèvres, 75012 Paris, France.
    Lymphedema results from impaired lymphatic transport with increased limb volume and is divided into primary and secondary forms. In children, primary lymphedema is the most frequent, with a sporadic, rarely familial form or associated with complex malformative or genetic disorders. Diagnosis of lymphedema is mainly clinical and lymphoscintigraphy is useful to assess the lymphatic function of both limbs precisely. Read More

    Interventions for the prevention of recurrent erysipelas and cellulitis.
    Cochrane Database Syst Rev 2017 06 20;6:CD009758. Epub 2017 Jun 20.
    Department of Dermatology, Beilinson Hospital, Rabin Medical Center, 39 Jabotinski Street, Petah Tikva, Israel, 49100.
    Background: Erysipelas and cellulitis (hereafter referred to as 'cellulitis') are common bacterial skin infections usually affecting the lower extremities. Despite their burden of morbidity, the evidence for different prevention strategies is unclear.

    Objectives: To assess the beneficial and adverse effects of antibiotic prophylaxis or other prophylactic interventions for the prevention of recurrent episodes of cellulitis in adults aged over 16. Read More

    Modern science for better quality control of medicinal products "Towards global harmonization of 3Rs in biologicals": The report of an EPAA workshop.
    Biologicals 2017 Jul 7;48:55-65. Epub 2017 Jun 7.
    National Institute for Biological Standards and Control (NIBSC), Blanche Lane, South Mimms, Potters Bar Hertfordshire EN6 3QG, United Kingdom. Electronic address:
    This article summarizes the outcome of an international workshop organized by the European Partnership for Alternative Approaches to Animal Testing (EPAA) on Modern science for better quality control of medicinal products: Towards global harmonization of 3Rs in biologicals. As regards the safety testing of biologicals, the workshop participants agreed to actively encourage the deletion of abnormal toxicity tests and target animal batch safety tests from all relevant legal requirements and guidance documents (country-specific guidelines, pharmacopoeia monographs, WHO recommendations). To facilitate the global regulatory acceptance of non-animal methods for the potency testing of, e. Read More

    The Genus Patrinia: A Review of Traditional Uses, Phytochemical and Pharmacological Studies.
    Am J Chin Med 2017 ;45(4):637-666
    * Honghui Hospital, Xi'an Jiaotong University College of Medicine, Xi'an 710054, P. R. China.
    The aim of the present review is to comprehensively outline the botanical description, traditional uses, phytochemistry, pharmacology and toxicology of Patrinia, and to discuss possible trends for the further study of medicinal plants from the genus Patrinia. The genus Patrinia plays an important role in Asian medicine for the treatment of erysipelas, conjunctival congestion with swelling and pain, peri-appendicular abscesses, lung carbuncle, dysentery, leucorrhea, and postpartum disease. More than 210 chemical constituents have been isolated and identified from Patrinia plants, especially P. Read More

    An Unusual Presentation of Deep Tissue Injury, Do We Really Understand It? A Case Report and Literature Review
    Wounds 2017 05;29(5):E32-E35
    Department of Pharmacology and Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, OH and Department of Dermatology, Boonshoft School of Medicine, Wright State University.
    Deep tissue injury (DTI) is an injury to the soft tissue under the skin due to pressure and is usually over boney prominence. This injury is commonly seen in bedridden patients in hospitals and nursing homes. Although many efforts were made to elucidate the precise mechanism and clinical presentation, the pathogenesis and the final clinical outcome are yet to be determined. Read More

    Tocilizumab in the treatment of twelve cases with aa amyloidosis secondary to familial mediterranean fever.
    Orphanet J Rare Dis 2017 05 30;12(1):105. Epub 2017 May 30.
    Division of Rheumatology, Department of Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey.
    Background: There is no established treatment of AA amyloidosis, a long-term complication of various chronic inflammatory diseases associated with increased mortality, such as familial Mediterranian fever (FMF). Recently there are few reports pointing out that tocilizumab(TCZ), an anti IL-6 agent may be effective in AA amyloidosis resistant to conventional treatments. We report our data on the effect of TCZ in patients with FMF complicated with AA amyloidosis. Read More

    Analysis of Serum Cytokines and Single-Nucleotide Polymorphisms of SOD1, SOD2, and CAT in Erysipelas Patients.
    J Immunol Res 2017 23;2017:2157247. Epub 2017 Apr 23.
    Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia.
    Increased free radical production had been documented in group A (-hemolytic) streptococcus infection cases. Comparing 71 erysipelas patients to 55 age-matched healthy individuals, we sought for CAT, SOD1, and SOD2 single polymorphism mutation (SNPs) interactions with erysipelas' predisposition and serum cytokine levels in the acute and recovery phases of erysipelas infection. Whereas female patients had a higher predisposition to erysipelas, male patients were prone to having a facial localization of the infection. Read More

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