84,012 results match your criteria Equine Veterinary Journal[Journal]


Cryo-EM Structures of Eastern Equine Encephalitis Virus Reveal Mechanisms of Virus Disassembly and Antibody Neutralization.

Cell Rep 2018 Dec;25(11):3136-3147.e5

Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA. Electronic address:

Alphaviruses are enveloped pathogens that cause arthritis and encephalitis. Here, we report a 4.4-Å cryoelectron microscopy (cryo-EM) structure of eastern equine encephalitis virus (EEEV), an alphavirus that causes fatal encephalitis in humans. Read More

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December 2018
1 Read

Comparison of ground reaction force measurements in a population of Domestic Shorthair and Maine Coon cats.

PLoS One 2018 12;13(12):e0208085. Epub 2018 Dec 12.

Department for Companion Animals and Horses, University Clinic for Small Animals, Small Animal Surgery, Section for Physical Therapy, University of Veterinary Medicine, Veterinärplatz, Vienna, Austria.

Current research on gait analysis mostly involves horses and dogs. Feline kinetics and kinematics are being investigated and receiving more clinical interest at present. Ground reaction forces measured on pressure-sensitive mattresses have been established in healthy Domestic Shorthair cats (DSH). Read More

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December 2018

Lower allergen levels in hypoallergenic Curly Horses? A comparison among breeds by measurements of horse allergens in hair and air samples.

PLoS One 2018 12;13(12):e0207871. Epub 2018 Dec 12.

Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-Universität Bochum (IPA), Bochum, Germany.

Background: Exposure to horses can cause severe allergic reactions in sensitized individuals. The breed, American Bashkir Curly Horse is categorized as hypoallergenic, primarily due to reports of allergic patients experiencing fewer symptoms while handling this special breed. The possible reasons for this phenomenon could be lower allergen production and/or reduced allergen release into the air because of increased sebum content in their skin and hair compared to other breeds. Read More

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December 2018
1 Read

Orbital compartment syndrome resulting in unilateral blindness in two dogs.

Open Vet J 2018 22;8(4):445-451. Epub 2018 Nov 22.

Department of Clinical Sciences, Companion and Equine Animals, Ophthalmology, University of Liège, Quartier Vallée 2, Avenue de Cureghem 3, 4000 Liège, Belgium.

Orbital compartment syndrome (OCS) is described in humans as an acute rise in intraorbital pressure following a severe and rapidly evolving orbital affection. It includes orbital oedema, haemorrhage or infection causing a marked reduction in local blood perfusion, and severely affecting the orbital neurovascular structures. If not promptly recognised and treated, it results in irreversible blindness. Read More

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November 2018

The prevalence of (Diptera: Oestridae) in donkeys () in Egypt with special reference to larvicidal effects of neem seed oil extract () on third stage larvae.

Open Vet J 2018 15;8(4):423-431. Epub 2018 Nov 15.

Department of Parasitology, Faculty of Veterinary Medicine, Cairo University, Giza, P.O. Box 12211, Egypt.

larvae are of veterinary and medical importance caused specific equine intestinal myiasis. (Botfly larvae) had a wide geographical distribution. The present study explores the prevalence rate of 3 stage larvae in Egypt from January- December 2017; besides, in vitro trials to control of this larvae and evaluation of this trial using Scanning Electron Microscope (SEM) and histopathology of treated larvae. Read More

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November 2018

Persistence of fluorescent nanoparticle-labeled bone marrow mesenchymal stem cells in vitro and after intra-articular injection.

J Tissue Eng Regen Med 2018 Dec 7. Epub 2018 Dec 7.

Department of Large Animal Clinical Sciences, Texas A&M University, College Station, TX, USA.

Mesenchymal stem cells (MSCs) improve the osteoarthritis condition, but the fate of MSCs after intra-articular injection is unclear. We used fluorescent nanoparticles (quantum dots; QDs) to track equine MSCs (QD-MSCs) in vivo after intra-articular injection to normal and osteoarthritic joints. One week after injection of QD-MSCs, unlabeled MSCs, or vehicle we determined the presence of QD-MSCs in synovium and articular cartilage histologically. Read More

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December 2018

Analysis of agriculture-related life-threatening injuries presenting to emergency departments of rural generalist hospitals in Southern Queensland.

Emerg Med Australas 2018 Dec 11. Epub 2018 Dec 11.

Sunshine Coast Hospital and Health Service, Sunshine Coast Region, Queensland, Australia.

Objective: Agricultural industries are among the most dangerous in Australia posing significant public health risks. This study analyses the nature and management of agriculture-related injuries presenting to EDs in selected hospitals in Southern Queensland.

Methods: Data on agricultural injury presentations over a 6 month period was collected at four rural hospitals by a dedicated onsite hospital data coordinator. Read More

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December 2018

Investigation of Hanwoo-specific structural variations using whole-genome sequencing data.

Genes Genomics 2018 Dec 8. Epub 2018 Dec 8.

Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan, 31116, Republic of Korea.

Background: The total length of the cattle genome is approximately ~ 3 billion base pairs. About half of the bovine genome (46.5%) is composed of transposable elements (TEs). Read More

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December 2018

Interaction Between Nutrition and Metabolism.

Exp Suppl 2018 ;109:29-114

Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.

Diet plays a fundamental role in the nutritional status, in the homeostasis and in the capacity of an individual to adapt to the environment. A proper or an inadequate nutrition has an impact on the persistence, remission and incidence of various conditions, including the infectious diseases. Consequently, nutrition has a crucial importance on survival rates and health recovery of individuals or even populations around the globe. Read More

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January 2018

Growth factor modulation of equine trophoblast mitosis and prostaglandin gene expression.

J Anim Sci 2018 Dec 11. Epub 2018 Dec 11.

Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA.

To provide insight into maternal recognition of pregnancy control in equids, the mitogenic and developmental effects of endometrium-expressed growth factors (epidermal growth factor (EGF), fibroblast growth factor 2 (FGF2), hepatocyte growth factor (HGF), insulin-like growth factor 1 (IGF-1)) were examined in equine iTr cells, an equine trophectoderm cell line. Initial Western blots revealed that HGF and IGF-1 stimulate phosphorylation of AKT serine/threonine kinase 1 (AKT1) and EGF, FGF2 or HGF resulted in phosphorylation of both extracellular signal-regulated kinase 1 (ERK1) and ERK2. Mitotic activity was stimulated (P < 0. Read More

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December 2018

Continued Evidence of Decline in the Enzootic Activity of Western Equine Encephalitis Virus in Colorado.

J Med Entomol 2018 Dec 6. Epub 2018 Dec 6.

Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.

Western equine encephalitis (WEE) was once prevalent and routinely isolated from mosquitoes in Colorado; however, isolations of Western equine encephalitis virus (WEEV) have not been reported from mosquito pools since the early 1990s. The objective of the present study was to test pools of Culex tarsalis (Coquillett) mosquitoes sampled from Weld County, CO, in 2016 for evidence of WEEV infection. Over 7,000 mosquitoes were tested, but none were positive for WEEV RNA. Read More

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December 2018

Draft Genome Sequence of Taylorella equigenitalis Strain 210217RC10635, Isolated from a Pony Stallion in Germany.

Microbiol Resour Announc 2018 Sep 27;7(12). Epub 2018 Sep 27.

Friedrich-Loeffler-Institut, Institute of Bacterial Infections and Zoonoses (IBIZ), Jena, Germany.

Here, we report the draft genome sequence of Taylorella equigenitalis strain 210217RC10635, a Gram-negative bacterium belonging to the genus Taylorella and the order Burkholderiales. Taylorella equigenitalis is the causative agent of contagious equine metritis (CEM). The strain reported here was isolated in 2017 from a German stallion. Read More

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September 2018

A comparison of helminth infections as assessed through coprological analysis and adult worm burdens in a wild host.

Int J Parasitol Parasites Wildl 2018 Dec 14;7(3):439-444. Epub 2018 Nov 14.

Department of Zoology, School of Natural Sciences, Trinity College Dublin, Ireland.

Coprological analysis is the most widely used diagnostic tool for helminth infection in both domestic and wild mammals. Evaluation of the efficacy of this technique is rare, due to the lack of availability of adult worm burden. Where information is available the majority of studies are in small ruminants and seldom in a wild host. Read More

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December 2018

Adherence to treatment recommendations and short-term outcome of pleasure and sport horses with equine asthma.

Can Vet J 2018 Dec;59(12):1293-1298

Clinical Sciences Department, Faculté de Médecine Vétérinaire, Université de Montréal, 3200 rue Sicotte, Saint-Hyacinthe, Quebec J2S 2M2.

Treatments for mild forms of equine asthma are extrapolated from those recommended for severe equine asthma (heaves), but little is known about owner's adherence to recommendations and treatment efficacy. The objective was to determine which recommendations are implemented by owners and their perception of the clinical response to treatment. Medical records of 43 horses diagnosed with moderate asthma between 2010 and 2012 were retrieved from the Université de Montréal database. Read More

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December 2018

In-vitro evaluation studies of 7-chloro-4-aminoquinoline Schiff bases and their copper complexes as cholinesterase inhibitors.

J Inorg Biochem 2018 Nov 30;191:183-193. Epub 2018 Nov 30.

Instituto de Química, Universidade Federal Fluminense, Campus do Valonguinho, 24020-141 Niterói, RJ, Brazil. Electronic address:

Alzheimer's disease (AD) is one of the most common age-related neurodegenerative disorders. Aggregation of amyloid-β peptide into extracellular plaques with incorporation of metal ions, such as Cu, and reduction of the neurotransmitter acetylcholine levels are among the factors associated to the AD brain. Hence, a series of 7-chloro-4-aminoquinoline Schiff bases (HLa-e) were synthesized and their cytotoxicity and anti-cholinesterase activity, assessed for Alzheimer's disease. Read More

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November 2018

How to score sedation and adjust the administration rate of sedatives in horses: a literature review and introduction of the Ghent Sedation Algorithm.

Vet Anaesth Analg 2018 Sep 19. Epub 2018 Sep 19.

Department of Surgery and Anaesthesia of Domestic Animals, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium; Department of Veterinary Surgery and Anaesthesiology, Faculty of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, SP, Brazil.

Objective: To summarize the different methods used to assess sedation and/or adjust the dose or administration rate of alpha-2 agonists in horses and to propose an algorithm to adjust the administration rate of a constant rate infusion of an alpha-2 agonist in horses.

Databases Used: PubMed and Web of Science; search terms: horse, sedation and score.

Conclusions: Most authors distinguish between sedation depth, sedation quality and degree of ataxia. Read More

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September 2018
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Cardiovascular images: vascular hamartoma of the mitral valve in a horse.

J Vet Cardiol 2018 Dec 18;20(6):399-404. Epub 2018 Oct 18.

Department of Veterinary Biosciences, The Ohio State University, 1925 Coffey Road, Columbus, OH 43210, USA. Electronic address:

An 8-month-old Hanoverian gelding was presented with a history of cardiac murmurs that were not apparent as a foal nor reported at the time of castration. Major echocardiographic findings included mitral valvular thickening, functional stenosis, and mitral regurgitation of sufficient severity to cause diastolic and systolic cardiac murmurs, left-sided volume overload, and pulmonary hypertension. Due to the hemodynamic severity of the lesion and poor prognosis for future performance and longevity, euthanasia was elected. Read More

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December 2018

Prevalence of osteochondral lesions in the fetlock and hock joints of Standardbred horses that survived bacterial infection before 6 months of age.

BMC Vet Res 2018 Dec 10;14(1):390. Epub 2018 Dec 10.

Equine Section, Department of Companion Animal Clinical Sciences, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Ullevålsveien 72, 0454, Oslo, Norway.

Background: Young Standardbred horses frequently develop fragments in joints. Some fragments represent osteochondrosis; others are considered developmental, but it is uncertain whether they result from preceding osteochondrosis. Osteochondrosis occurs as a consequence of failure of the cartilage canal blood supply and ischaemic chondronecrosis. Read More

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December 2018

Bio-ink development for three-dimensional bioprinting of hetero-cellular cartilage constructs.

Connect Tissue Res 2018 Dec 10:1-15. Epub 2018 Dec 10.

a Department of Orthopaedics, University Medical Center Utrecht , Utrecht University , Utrecht , The Netherlands.

Bioprinting is a promising tool to fabricate organized cartilage. This study aimed to investigate the printability of gelatin-methacryloyl/gellan gum (gelMA/gellan) hydrogels with and without methacrylated hyaluronic acid (HAMA), and to explore (zone-specific) chondrogenesis of chondrocytes, articular cartilage progenitor cells (ACPCs), and multipotent mesenchymal stromal cells (MSCs) embedded in these bio-inks. The incorporating of HAMA in gelMA/gellan bio-ink increased filament stability, as measured using a filament collapse assay, but did not influence (zone-specific) chondrogenesis of any of the cell types. Read More

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December 2018

Seroepidemiological and molecular investigations of infections with Crimean-Congo haemorrhagic fever virus in Kazakhstan.

Int J Infect Dis 2018 Oct 25;78:121-127. Epub 2018 Oct 25.

Bundeswehr Institute of Microbiology, Department Virology and Intracellular Agents, German Centre for Infection Research, Munich Partner Site, Munich, Germany. Electronic address:

Objectives: The aim of this study was to detect the seroprevalence of Crimean-Congo haemorrhagic fever virus (CCHFV) in patients with fever of unknown origin (FUO) in endemic (Kyzylorda) and non-endemic (Almaty) oblasts of Kazakhstan.

Methods: Paired serum samples from 802 patients with FUO were collected. Serum samples were investigated by ELISA to detect IgG and IgM antibodies against CCHFV. Read More

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October 2018

Allergen-specific immunoglobulin E in sera of horses affected with insect bite hypersensitivity, severe equine asthma or both conditions.

J Vet Intern Med 2018 Dec 6. Epub 2018 Dec 6.

Department of Clinical Research, University of Bern, Berne, Switzerland.

Background: Genetic, epidemiologic, and clinical evidence suggests that, in horses, there are manifestations of hypersensitivity that can occur together.

Objectives: To investigate whether concurrent insect bite hypersensitivity (IBH) and severe equine asthma (EA) is associated with higher allergen-specific and total serum immunoglobulin E (IgE) concentrations than only EA or IBH.

Animals: Healthy control horses (C, n = 40), horses with IBH (IBH, n = 24), severe EA (EA, n = 18), and both conditions (IBH/EA, n = 23) were included. Read More

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December 2018

Strangles, convalescent Streptococcus equi subspecies equi M antibody titers, and presence of complications.

J Vet Intern Med 2018 Dec 6. Epub 2018 Dec 6.

Equine Diagnostic Solutions LLC, Lexington, Kentucky.

Background: Streptococcus equi subspecies equi infection elicits M protein antibody titers in equids. Interpretation of titers is not generally accepted.

Hypothesis: The magnitude of S. Read More

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December 2018
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Physical response of dogs supplemented with fish oil during a treadmill training programme.

J Anim Physiol Anim Nutr (Berl) 2018 Dec 5. Epub 2018 Dec 5.

Laboratory of Veterinary Physiotherapy (LAFIVET), School of Veterinary Sciences (FCV), National University of La Plata (UNLP), Buenos Aires, Argentina.

The rise in popularity of dog sports competitions has led to the evaluation of improvements in dog physical performance. The potential benefit of dietary supplementation with fish oil (FO) on the physical performance of human beings and horses has been reported. However, such effect has not been studied in dogs. Read More

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December 2018

Influence of dietary restriction and low-intensity exercise on weight loss and insulin sensitivity in obese equids.

J Vet Intern Med 2018 Dec 5. Epub 2018 Dec 5.

Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Werribee, Victoria, Australia.

Background: The importance of including exercise with dietary modification for the management of obese equids is not clearly understood.

Objectives: To evaluate the effect of a practical low-intensity exercise regimen, in addition to dietary restriction, on indices of insulin sensitivity (SI) and plasma adipokine concentrations in obese equids.

Animals: Twenty-four obese (body condition score [BCS] ≥ 7/9) horses and ponies. Read More

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December 2018
2 Reads

Viral testing of 18 consecutive cases of equine serum hepatitis: A prospective study (2014-2018).

J Vet Intern Med 2018 Dec 5. Epub 2018 Dec 5.

Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York.

Background: Three flaviviruses (equine pegivirus [EPgV]; Theiler's disease-associated virus [TDAV]; non-primate hepacivirus [NPHV]) and equine parvovirus (EqPV-H) are present in equine blood products; the TDAV, NPHV, and EqPV-H have been suggested as potential causes of serum hepatitis.

Objective: To determine the prevalence of these viruses in horses with equine serum hepatitis.

Animals: Eighteen horses diagnosed with serum hepatitis, enrolled from US referral hospitals. Read More

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December 2018

Viral testing of 10 cases of Theiler's disease and 37 in-contact horses in the absence of equine biologic product administration: A prospective study (2014-2018).

J Vet Intern Med 2018 Dec 6. Epub 2018 Dec 6.

Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York.

Background: A novel equine parvovirus (EqPV-H) was recently discovered in the equine liver with Theiler's disease.

Objectives: To determine the prevalence of EqPV-H infection in naturally occurring Theiler's disease cases and in-contact horses in the absence of historical equine biologic product administration.

Animals: Ten cases of Theiler's disease from 6 separate properties were included in the study, based on the criteria of acute onset of clinical signs of liver failure with laboratory or histopathologic findings characteristic of Theiler's disease and no history of receiving an equine biologic product within the preceding 4 months. Read More

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December 2018

The use of heart rate variability analysis to detect arrhythmias in horses undergoing a standard treadmill exercise test.

J Vet Intern Med 2018 Dec 5. Epub 2018 Dec 5.

Equine Department, Clinic for Equine Internal Medicine, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.

Background: Little is known about normal heart rate variability (HRV) in horses during exercise. It can be difficult to separate premature beats from normal beat-to-beat variation at higher heart rates.

Objectives: The aim was to quantify HRV in healthy horses during a high-speed treadmill-standardized exercise test (HSET) and to compare with the HRV in horses observed to have arrhythmias during exercise. Read More

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December 2018
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The effect of insulin on equine lamellar basal epithelial cells mediated by the insulin-like growth factor-1 receptor.

PeerJ 2018 29;6:e5945. Epub 2018 Nov 29.

Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Melbourne, VIC, Australia.

Background: In horses and ponies, insulin dysregulation leading to hyperinsulinemia may be associated with increased risk of laminitis, and prolonged infusion of insulin can induce the condition. It is unclear whether insulin may have a direct or indirect effect on the lamellar tissues. Insulin is structurally related to insulin-like growth factor (IGF-1), and can bind the IGF-1 receptor, albeit at a lower affinity than IGF-1. Read More

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November 2018
2 Reads

West Nile virus in Algeria: a comprehensive overview.

New Microbes New Infect 2019 Jan 21;27:9-13. Epub 2018 Oct 21.

UMR VITROME, Aix-Marseille Université, IRD, Service de Santé des Armées, Assistance Publique-Hôpitaux de Marseille, IHU Méditerranée-Infection, Marseille, France.

West Nile virus (WNV) is a mosquito-borne virus belonging to the genus related to the Japanese encephalitis antigenic complex of family. It is transmitted by the bite of infected mosquitoes. The virus is maintained in a mosquito-bird-mosquito transmission cycle. Read More

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January 2019
2 Reads

Relationship between anti-Müllerian hormone and fertility in the mare.

Theriogenology 2018 Nov 22;125:335-341. Epub 2018 Nov 22.

Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, USA.

The objectives of this study were to evaluate; 1) the stability of measured serum anti-Müllerian hormone (AMH) concentrations in samples after multiple freeze-thaw cycles, 2) the repeatability of AMH concentrations within mares during the same breeding season as well as across breeding seasons, and 3) the relationship between serum AMH concentrations and fertility (measured as first cycle pregnancy rates) in thoroughbred mares. For the first aim, AMH concentrations (n = 9) were examined across four freeze-thaw cycles with no significant change in measured AMH concentrations. For the second aim, serum AMH concentrations (n = 12) were examined over three successive estrous cycles and over two successive breeding seasons and AMH levels were significantly correlated for individual animals within (r; 0. Read More

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November 2018
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The route of administration, timing, duration and dose of postmenopausal hormone therapy and cardiovascular outcomes in women: a systematic review.

Hum Reprod Update 2018 Dec 1. Epub 2018 Dec 1.

Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.

Background: The effect of postmenopausal hormone therapy (HT) on cardiovascular disease (CVD) risk remains controversial.

Objective And Rationale: We aimed to systematically review the evidence regarding the role of dose, route of hormone administration, timing of initiation and duration of HT on cardiovascular risk among postmenopausal women.

Search Methods: The electronic databases Medline Ovid, Web of Science and Cochrane Central were systematically searched to identify studies published before 30 January 2018. Read More

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December 2018
4 Reads

MicroRNA characterization in equine induced pluripotent stem cells.

PLoS One 2018 3;13(12):e0207074. Epub 2018 Dec 3.

LIAN-CONICET, Fundación FLENI, Buenos Aires, Argentina.

Cell reprogramming has been well described in mouse and human cells. The expression of specific microRNAs has demonstrated to be essential for pluripotent maintenance and cell differentiation, but not much information is available in domestic species. We aim to generate horse iPSCs, characterize them and evaluate the expression of different microRNAs (miR-302a,b,c,d, miR-205, miR-145, miR-9, miR-96, miR-125b and miR-296). Read More

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December 2018
5 Reads

Do dGEMRIC and T2 Imaging Correlate With Histologic Cartilage Degeneration in an Experimental Ovine FAI Model?

Clin Orthop Relat Res 2018 Nov 29. Epub 2018 Nov 29.

F. Schmaranzer, E. F. Liechti, M. Tannast, Department of Orthopaedic Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland L. Arendt, K. Nuss, B. von Rechenberg, M. Tannast, Musculoskeletal Research Unit (MSRU), Equine Hospital, Vetsuisse Faculty, University of Zürich, Zürich, Switzerland P. R. Kircher, Department of Small Animals, Division of Diagnostic Imaging, Vetsuisse Faculty, University of Zürich, Zürich, Switzerland.

Background: Biochemical MRI of hip cartilage such as delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) and T2 mapping is increasingly used to judge cartilage quality in the assessment of femoroacetabular impingement (FAI). The current evidence is sparse about which of these techniques yields a stronger correlation with histologic cartilage degeneration because of the difficulty in validating biochemical MRI techniques against histology in the clinical setting. Recently, an experimental ovine FAI model was established that induces chondrolabral damage and offers a validated platform to address these limitations. Read More

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November 2018
2 Reads

A non-coding regulatory variant in the 5'-region of the MITF gene is associated with white-spotted coat in Brown Swiss cattle.

Anim Genet 2018 Dec 2. Epub 2018 Dec 2.

Institute of Genetics, Vetsuisse Faculty, University of Bern, 3001, Bern, Switzerland.

Recently, the Swiss breeding association reported an increasing number of white-spotted cattle in the Brown Swiss breed, which is normally solid brown coloured. A total of 60 Brown Swiss cattle with variably sized white abdominal spots, facial markings and depigmented claws were collected for this study. A genome-wide association study using 40k SNP genotypes of 20 cases and 1619 controls enabled us to identify an associated genome region on chromosome 22 containing the MITF gene, encoding the melanogenesis associated transcription factor. Read More

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December 2018

Insulin and incretin responses to grazing in insulin-dysregulated and healthy ponies.

J Vet Intern Med 2018 Dec 2. Epub 2018 Dec 2.

Department of Bioscience, Science and Engineering Faculty, Queensland University of Technology, Brisbane, Queensland, Australia.

Background: Supraphysiological insulin and incretin responses to a cereal-based diet have been described in horses and ponies with insulin dysregulation (ID). However, the hormonal responses to grazing have not yet been described.

Objectives: To determine if there is a difference in the insulin and incretin responses to grazing pasture between insulin-dysregulated and healthy ponies. Read More

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December 2018

Differences in miRNA differential expression in whole blood between horses with sarcoid regression and progression.

J Vet Intern Med 2018 Dec 2. Epub 2018 Dec 2.

Swiss Institute of Equine Medicine, Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Bern, Bern, Switzerland.

Background: Currently no methods are available to predict the clinical outcome of individual horses with equine sarcoid (ES) disease.

Objective: To investigate if whole blood microRNA (miRNA) profiles can predict the long-term development of ES tumors.

Animals: Five horses with regression and 5 with progression of ES lesions monitored over 5-7 years and 5 control horses free of ES for at least 5 years. Read More

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December 2018

Detection of West Nile virus lineage 2 in North-Eastern Spain (Catalonia).

Transbound Emerg Dis 2018 Dec 1. Epub 2018 Dec 1.

IRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Bellaterra, Spain.

In September 2017, WNV lineage 2 was detected in Catalonia (Northern Spain) in northern goshawks by passive surveillance. The phylogenetic analyses showed that it was related to the Central/Southern European strains, evidencing WNV lineage 2 spread to Western Europe. WNV local transmission was later detected in bearded vultures housed at the Wildlife Recovery center where the goshawk was transferred to. Read More

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December 2018
1 Read

Physiological outcomes of calming behaviors support the resilience hypothesis in horses.

Sci Rep 2018 Nov 30;8(1):17501. Epub 2018 Nov 30.

Department of Veterinary Sciences, University of Pisa, Pisa, Italy.

To manage a stressful stimulus animals react both behaviorally and physiologically to restore the homeostasis. In stable horses, a stressful stimulus can be represented by social separation, riding discomfort or the presence of novel objects in their environment. Although Heart Rate Variability is a common indicator of stress levels in horses, the behavioral mechanisms concurrently occurring under stressful conditions are still unknown. Read More

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November 2018
1 Read

Ten-minute chat.

Authors:

Vet Rec 2018 Dec;183(21):ii

A love of the outdoors is helping equine vet fight depression. As part of his recovery, he has applied to join the Fjällräven Polar 2019 expedition, which he hopes will inspire others to start a conversation about their mental health. Read More

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December 2018

Functionalized CD133 antibody coated stent surface simultaneously promotes EPCs adhesion and inhibits smooth muscle cell proliferation-A novel approach to prevent in-stent restenosis.

Colloids Surf B Biointerfaces 2018 Nov 26;174:587-597. Epub 2018 Nov 26.

Department of Biomedical Engineering, Faculty of Fundamental Problems of Technology, Wrocław University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50-370 Wrocław, Poland. Electronic address:

We report a multistep strategy of biochemical surface modifications that resulted in the synthesis of new, effective and biocompatible intravascular implants coating with immobilized anti-CD133 antibodies, that proved to be the most effective in endothelial progenitor cells capture and reduced smooth muscle cells growth. Biomolecules were immobilized on differently functionalized surfaces. The distribution, nanostructural characteristics and intramolecular interactions of anti-CD133 molecules as well as their ability to bind EPCs was evaluated. Read More

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November 2018

"When you hear hoofbeats, think of horses not zebras": a case of bladder endometriosis in menopause.

J Minim Invasive Gynecol 2018 Nov 29. Epub 2018 Nov 29.

Department of Obstetrics and Gynecology of Macedonio Melloni Hospital, University of Milan, Milan, Italy.

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November 2018
1 Read

Recent advances in the development of monoclonal antibodies for rabies post exposure prophylaxis: A review of the current status of the clinical development pipeline.

Vaccine 2018 Nov 29. Epub 2018 Nov 29.

The World Health Organization, Geneva, Switzerland.

Despite successful control in many parts of the world, rabies virus continues to result in tens of thousands of deaths each year. Death from rabies can be prevented by timely and appropriate post exposure prophylaxis including wound cleaning and administration of vaccine and rabies immunoglobulin. Currently, rabies immunoglobulin is derived from the blood plasma of horses or humans and has several limitations relating to supply, cost and quality. Read More

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November 2018

Sequence and functional variability of Toll-like receptor 9 gene in equines.

Mol Immunol 2018 Nov 28. Epub 2018 Nov 28.

ICAR-National Research Centre on Equines, Sirsa Road, Hisar, 125001, Haryana, India.

Significant structural differences in the extracellular domain of toll-like receptor 9 (TLR9) account for species-specific recognition of its ligand CpG-ODN sequences. TLR9 is extensively studied in human, mice and some domestic animals. The recognition ability appears to be utilized differently by various species and breeds, but so far no comprehensive study exists about the equine TLR9 gene. Read More

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November 2018

Diclazuril nonlinear mixed-effects pharmacokinetic modelling of plasma concentrations after oral administration to adult horses every 3-4 days.

Vet J 2018 Dec 8;242:74-76. Epub 2018 Nov 8.

Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, One Shields Avenue, Davis, CA 95616, USA. Electronic address:

The purpose of this study was to determine if a low dose of diclazuril (0.5mg/kg of 1.56% diclazuril pellets) given to six healthy adult horses every 3-4 days for a total of five administrations would achieve steady-state plasma concentrations known to be inhibitory to Sarcocystis neurona and Neospora caninum. Read More

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December 2018

Effects of dexmedetomidine and MK-467 on plasma glucose, insulin and glucagon in a glibenclamide-induced canine hypoglycaemia model.

Vet J 2018 Dec 21;242:33-38. Epub 2018 Sep 21.

Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Viikintie 49, FI-00014 Helsinki, Finland.

The commonly used sedative α-adrenoceptor agonist dexmedetomidine has adverse cardiovascular effects in dogs that can be prevented by concomitant administration of the peripherally acting α-adrenoceptor antagonist MK-467. An ancillary effect of dexmedetomidine is to decrease insulin release from the pancreas, whereas MK-467 stimulates insulin release. This study assessed the effects of co-administered dexmedetomidine and MK-467 in a canine glibenclamide-induced hypoglycaemia model. Read More

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December 2018
1 Read

Objective pain assessment in horses (2014-2018).

Vet J 2018 Dec 9;242:1-7. Epub 2018 Oct 9.

Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 114, NL-3584 CM Utrecht, The Netherlands; Veterinary Faculty Ghent University, Salisburylaan 133, 9820 Merelbeke, Ghent, Belgium; Department of Veterinary Sciences Antwerp University, Universiteitsplein 1, 2610, Wilrijk, Antwerp, Belgium.

In recent decades, much effort has been invested in scientific studies of objective and reliable assessment of pain in horses. Various types of pain assessment tools have been described and (partly) validated for different types of pain in horses. Currently, composite pain scales and facial expression-based pain scales seem to be the most promising tools for pain assessment in horses and numerous studies have recently been published on the use of these pain scales in horses. Read More

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December 2018

Resistance to pyrantel embonate and efficacy of fenbendazole in Parascaris univalens on Swedish stud farms.

Vet Parasitol 2018 Dec 10;264:69-73. Epub 2018 Nov 10.

Swedish University of Agricultural Sciences, Department of Biomedical Sciences and Veterinary Public Health, Division of Parasitology, Uppsala, Sweden.

The aims of this study were to determine the species of Parascaris present in foals in Sweden and to establish whether anthelmintic resistance to pyrantel and fenbendazole is present on Swedish stud farms. Ascarid eggs collected from different regions in Sweden were karyotyped and were all identified as Parascaris univalens, characterized by one chromosomal pair. Faecal egg count reduction tests were performed on a total of 142 foals on 9 farms between September 2016 and May 2017. Read More

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December 2018

Melarsomine hydrochloride (Cymelarsan) fails to cure horses with Trypanosoma equiperdum OVI parasites in their cerebrospinal fluid.

Vet Parasitol 2018 Dec 9;264:47-51. Epub 2018 Nov 9.

ANSES, Dozulé Laboratory for Equine Diseases, Bacteriology Unit, 14430, Goustranville, France.

The aim of this study was to evaluate the ability of melarsomine hydrochloride (Cymelarsan) to cure horses suffering from a nervous form of dourine, a sexually-transmitted disease caused by Trypanosoma equiperdum. The recently described experimental model for assessing drug efficacy against horse trypanosomosis allowed us to obtain eight horses (Welsh pony mares) infected by T. equiperdum with parasites in their cerebrospinal fluid. Read More

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December 2018

Transplacental transmission of Theileria equi in mules: Should we worry?

Vet Parasitol 2018 Dec 26;264:39-41. Epub 2018 Oct 26.

College of Veterinary Medicine and Animal Science, University of São Paulo, Department of Internal Medicine, São Paulo, Brazil. Electronic address:

Equine piroplasmosis, disease globally responsible for significant economic losses, is caused by the transmission of the hemoprotozoa Theileria equi and Babesia caballi by ticks. Transplacental transmission has been reported previously in horses, which is not the case for mules´ foals. The present study investigated, by Real Time-PCR (RT-PCR), the presence of both Theileria equi and Babesia caballi in newborn mules before the ingestion of colostrum. Read More

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December 2018