27,899 results match your criteria Epitheliomas Basal Cell


Trichoblastic Carcinosarcoma of the Skin: A Case Report and Literature Review.

Am J Dermatopathol 2018 Jun 14. Epub 2018 Jun 14.

Dermatology, Hôpital d'Instruction des Armées Sainte-Anne, Toulon, France.

An 83-year-old man presented to the dermatology department for an ulcerated skin lesion of the back that had been increasing in size during the past 11 years. The physical examination revealed a well-defined, fleshy, reddish plaque measuring 10 × 20 cm in diameter with erosions and black areas on the surface. The patient underwent surgical excision with margins of 10 mm followed by a skin graft. Read More

View Article

Design, synthesis and biological evaluation of deuterated Vismodegib for improving pharmacokinetic properties.

Bioorg Med Chem Lett 2018 Jun 15. Epub 2018 Jun 15.

State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center of Biotherapy, West China Hospital, West China Medical School of Sichuan University, Chengdu 610041, China; Hinova Pharmaceuticals Inc., Suite 402, Building B, #5 South KeYuan Road, Chengdu 610041, China. Electronic address:

Vismodegib is an oral and high selective hedgehog (Hh) inhibitor used for the treatment of basal cell carcinoma (BCC). In this work, analogs of Vismodegib with deuterium-for-hydrogen replacement at certain metabolically active sites were prepared and found to have a better pharmacokinetic properties in mice. In particular, deuterated compound SKLB-C2211 obviously altered the blood circulation behavior compared to its prototype, which was demonstrated by significantly prolonged blood circulation half-life time (t) and increased AUC. Read More

View Article

Basal Cell Carcinoma Mimicking Desmoplastic Trichoepithelioma: A Case with Correlation of Dermoscopy and Histology.

Case Rep Dermatol 2018 May-Aug;10(2):133-137. Epub 2018 May 18.

Dermatology Clinic, University Hospital Zurich, Zurich, Switzerland.

Basal cell carcinoma (BCC) is the most common cancer in humans worldwide. Many highly specific dermoscopic criteria for BCC are well established in the literature. On the contrary, other malignant or benign skin tumors may mimic BCC by exhibiting similar or even the same dermoscopic features and therefore obscuring the diagnosis of BCC in certain situations. Read More

View Article

Needs and preferences of patients regarding basal cell carcinoma and cutaneous squamous cell carcinoma care: a qualitative focus group study.

Br J Dermatol 2018 Jun 21. Epub 2018 Jun 21.

Department of Dermatology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.

Background: Despite the high and rising incidence rate of keratinocyte cancer (KC) and the importance of incorporating patient values in evidence-based care, few studies have focused on the perspectives of KC patients.

Objectives: To identify the needs and preferences of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) patients regarding care.

Methods: A qualitative study consisting of three focus groups with BCC patients and three focus groups with SCC patients was conducted. Read More

View Article

Dermoscopy of chondrodermatitis nodularis helicis.

Arch Dermatol Res 2018 Jun 20. Epub 2018 Jun 20.

Department of Dermatology, Central University Hospital of Asturias, Avda. Roma s/n, 33011, Oviedo, Spain.

Chondrodermatitis nodularis helicis (CNH) is a benign auricular disease whose differentiation with nonpigmented tumors is mandatory. Clinical characteristics of CNH are well known, but there is no information about the dermoscopic features that could help differentiate CNH from squamous cell carcinoma and other non-melanoma skin cancers. To describe the dermoscopic appearance of CNH and to formulate a differential diagnostic model, we conducted  a retrospective, single center, observational dermoscopic study on a sample of 189 biopsy-proven lesions: 25 CNH; 26 squamous cell carcinomas; 62 basal cell carcinomas and 76 other benign and malignant tumors. Read More

View Article

[Basal cell carcinoma or Bowen's disease].

Hautarzt 2018 Jun 20. Epub 2018 Jun 20.

Klinik für Dermatologie, Allergologie und Umweltmedizin, Derma II, Städtisches Klinikum München, München, Deutschland.

View Article

Solitary plantar basal cell carcinoma.

An Bras Dermatol 2018 Jun;93(3):419-421

Dermatologic Surgery Service, Hospital Heliópolis, São Paulo, SP, Brazil.

Basal cell carcinoma is the most frequent skin cancer, generally located in hair-bearing, sunlight-exposed areas. Basal cell carcinoma usually occurs on the head and neck, but very rarely on extra-facial locations. We report a case of a 65-year-old woman presenting with a solitary non-healing ulcer on the sole of the right foot for two years. Read More

View Article

The new 8th edition of TNM staging and its implications for skin cancer: a review by the British Association of Dermatologists and the Royal College of Pathologists, United Kingdom.

Br J Dermatol 2018 Jun 19. Epub 2018 Jun 19.

Chesterfield Royal Hospital NHS Foundation Trust, Chesterfield, U.K.

The 8th edition of TNM (Tumour, Node and Metastasis) has numerous and important changes compared to the 7th edition. Public Health England (PHE) and the Royal College of Pathologists, United Kingdom (RCPath) have adopted the 8th edition of TNM (TNM8) published by the Union for International Cancer Control (UICC) for skin cancer staging. These changes will have an impact on the management of both non-melanoma and melanoma skin cancer by all members of the skin cancer multidisciplinary team. Read More

View Article
June 2018
1 Read

Sonidegib for basal cell carcinoma.

Authors:

Aust Prescr 2018 Jun 15;41(3):94. Epub 2018 May 15.

View Article

Genital basal cell carcinoma, a different pathogenesis from sun-exposed basal cell carcinoma? A case-control study of 30 cases.

J Cutan Pathol 2018 Jun 19. Epub 2018 Jun 19.

Department of Dermatology, MacKay Memorial Hospital, Taipei, Taiwan.

Background: Genital basal cell carcinoma (BCC) accounts for <1% of all BCCs. We aimed to elucidate the pathogenesis of genital BCC.

Methods: We retrospectively evaluated cases of pathologically diagnosed genital BCC between 1990 and 2016 in an Asian tertiary referral center. Read More

View Article
June 2018
5 Reads

Diagnostic Accuracy of Immunohistochemical Markers in Differentiation between Basal Cell Carcinoma and Trichoepithelioma in small Biopsy Specimens.

J Cutan Pathol 2018 Jun 19. Epub 2018 Jun 19.

Dermatology Department, Faculty of medicine, Zagazig University.

Background: The distinction of trichoepithelioma from basal cell carcinoma in small superficial biopsies is important but often challenging. This has inspired many scientists to test the validity of immunohistochemical markers in the differential diagnosis.

Objectives: to develop an immunohistochemical protocol that helps in differentiation between both TE and BCC with higher sensitivity and specificity. Read More

View Article

Graviola (Annona muricata) Exerts Anti-Proliferative, Anti-Clonogenic and Pro-Apoptotic Effects in Human Non-Melanoma Skin Cancer UW-BCC1 and A431 Cells In Vitro: Involvement of Hedgehog Signaling.

Int J Mol Sci 2018 Jun 16;19(6). Epub 2018 Jun 16.

Department of Basic Pharmaceutical Sciences, School of Pharmacy, College of Health and Pharmaceutic Sciences, University of Louisiana at Monroe, Monroe, 71209-0497 LA, USA.

Non-melanoma skin cancers (NMSCs) are the leading cause of skin cancer-related morbidity and mortality. Effective strategies are needed to control NMSC occurrence and progression. Non-toxic, plant-derived extracts have been shown to exert multiple anti-cancer effects. Read More

View Article
June 2018
1 Read

Biomarkers of aggressiveness in genitourinary tumors with emphasis on kidney, bladder and prostate cancer.

Expert Rev Mol Diagn 2018 Jun 18. Epub 2018 Jun 18.

a Section of Pathological Anatomy , Polytechnic University of the Marche Region, School of Medicine, United Hospitals , Ancona , Italy.

Introduction: Over the last decade, the improvement in molecular techniques and the acquisition of genomic information has transformed and increased the quality of patient care and our knowledge of diseases. Areas covered: Protein expression levels in immunohistochemistry and molecular biomarkers are reported for their ability to predict recurrence, progression, development of metastases, or patient survival. In particular, for renal cell carcinoma, we take into consideration the biomarkers applicable to immunohistochemistry and with molecular and genetic analyses. Read More

View Article

Basal Cell Carcinoma of the Buttock.

Authors:
Philip R Cohen

Skinmed 2018 1;16(2):105-110. Epub 2018 Apr 1.

Division of Dermatology, University of California San Diego School of Medicine, San Diego, CA;

Basal cell carcinoma of the buttock is rare, and only 28 patients have been described. An extensive literature search was performed on basal cell carcinoma and buttock using the PubMed database. The literature was evaluated, and the characteristics of individuals with basal cell carcinoma of the buttock were summarized. Read More

View Article

Histological changes of superficial esophageal squamous cell carcinoma after preoperative chemotherapy.

Esophagus 2018 Jun 16. Epub 2018 Jun 16.

Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan.

Introduction: We aimed to analyze the clinical and histological effects of chemotherapy in superficial esophageal squamous cell carcinoma (SESCC).

Methods: We analyzed tumor samples from five patients with cT1bN1M0 who underwent subtotal esophagectomy following two courses of a new triplet chemotherapy regimen including docetaxel, cisplatin, and 5-fluorouracil (DCF). To assess the histological effects of chemotherapy, resected specimens were analyzed by macroscopic examination, hematoxylin & eosin (HE) staining, immunohistochemical (IHC) staining (p53, Ki-67 and cytokeratin) and periodic acid-Schiff (PAS) staining. Read More

View Article

CUTANEOUS POLYPOID MELANOMA OF HEAD AND NECK.

Georgian Med News 2018 May(278):68-71

1Department of Dermatology and Allergology; 2Institue of Pathology "Georg Schmorl", Städtisches Klinikum Dresden, Academic Teaching Hospital of the Technical University, Dresden, Germany.

Cutaneous polypoid melanoma is an uncommon subtype of malignant melanoma. The clinical behavior of this subtype has been described as aggressive. Tumors can be sessile or pedunculated. Read More

View Article
May 2018
1 Read

Basal cell carcinoma and malignant melanoma cutaneous collision tumor.

Proc (Bayl Univ Med Cent) 2018 Jul 26;31(3):362-363. Epub 2018 Apr 26.

Department of Nursing, University of San Francisco School of Nursing, San Francisco, California.

Malignant tumors composed of both epithelial and melanocytic populations are exceedingly rare. Because the etiology of these malignant tumors is not yet defined, several authors have argued for the continued cataloging of these lesions. We present a 67-year-old man with a suspicious-appearing lesion on the right forearm; initial biopsy was consistent with a pigmented basal cell carcinoma. Read More

View Article
July 2018
1 Read

[Application of Mohs microsurgery in nasal basal cell carcinoma].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Jun;53(6):440-443

Department of Otorhinolaryngology, Qilu Hospital of Shandong University, Jinan 250012, China.

To discuss the application of Mohs microsurgery in nasal and facial basal cell carcinoma (BCC) and analyze the pathological and clinical features. The clinical data of 127 patients who were diagnosed by pathology as nasal and facial BCC in Qilu Hospital of Shandong University from January 2010 to January 2015 were retrospectively analysed. The value of Mohs microsurgery was discussed and the nasal & facial sites of BCC lesions, clinical and histopathology features were summarized. Read More

View Article

Collagen disruption as a marker for basal cell carcinoma in presurgical margin detection.

Lasers Surg Med 2018 Jun 14. Epub 2018 Jun 14.

Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts.

Introduction And Objective: Nonmelanoma skin cancers (NMSCs) are the most common malignancies in the United States. Surgery is the most common treatment for these tumors, but pre-operative identification of surgical margins is challenging. The objective in this study was to determine whether optical polarization imaging (OPI) could be used prior to surgery to detect the extent of subclinical tumor spread by monitoring disruption in collagen. Read More

View Article

Heterogeneous relationships of squamous and basal cell carcinomas of the skin with smoking: the UK Million Women Study and meta-analysis of prospective studies.

Br J Cancer 2018 Jun 14. Epub 2018 Jun 14.

Population Health Department, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.

Introduction: Published findings on the associations between smoking and the incidence of cutaneous squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) are inconsistent. We aimed to generate prospective evidence on these relationships overall and by anatomical site.

Methods: We followed 1,223,626 women without prior cancer by electronic linkage to national cancer registration data. Read More

View Article
June 2018
1 Read

Functional Reconstruction with Latissimus Dorsi Flap following Resection of an Extensive Basal Cell Carcinoma in the Shoulder Region: A Case Report.

Surg J (N Y) 2018 Apr 11;4(2):e87-e90. Epub 2018 Jun 11.

Department of Plastic, Aesthetic, Reconstructive and Hand Surgery, AGAPLESION Diakonieklinikum Rotenburg, Rotenburg (Wümme), Germany.

Large and ulcerating skin tumors have become a rarity in the modern Western world. However, these conditions can cause serious life-threatening complications. The case of a 60-year-old male Caucasian patient is reported, who had suffered from an extensive basal cell carcinoma in the right shoulder region for several years. Read More

View Article

A case of a patient with severe renal failure on hemodialysis treated with vismodegib for relapsing basal cell carcinoma.

Tumori 2018 Jun 1:300891618778952. Epub 2018 Jun 1.

2 U.O. Oncologia Medica 1, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.

Introduction: Basal cell carcinoma (BCC) is the most common skin cancer. Treatment options for metastatic or locally advanced BCC inappropriate for surgery or radiotherapy were poor until vismodegib was approved for use in this setting. This drug can be safely used in patients with mild to moderate renal impairment, but limited data are available for its use in case of severe kidney failure. Read More

View Article

Differentiation of Different Nonmelanoma Skin Cancer Types Using OCT.

Skin Pharmacol Physiol 2018 Jun 12;31(5):238-245. Epub 2018 Jun 12.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Background: Early detection of various types of nonmelanoma skin cancer has been a challenge in dermatology. Noninvasive examination procedures such as optical coherence tomography (OCT) play an increasingly important role, besides the established gold standard of histological tissue sample analysis. OCT is a noninvasive, cross-sectional, real-time technique that allows conclusions to be drawn with regard to the presence of pathologies. Read More

View Article

Clinicopathological, Immunohistochemical and molecular correlation of neural crest transcription factor SOX10 expression in triple negative breast carcinoma.

Hum Pathol 2018 Jun 9. Epub 2018 Jun 9.

Department of Pathology, University Hospitals Cleveland Medical Center, Cleveland, OH.

The transcription factor SOX10 mediates the differentiation of neural crest-derived cells, and SOX10 by immunohistochemistry(IHC) is used primarily for the diagnosis of melanoma. SOX10 expression has been previously documented in benign breast myoepithelial cells. However there is limited literature on its expression in triple negative breast carcinoma(TNBC). Read More

View Article
June 2018
3 Reads

Squamoid eccrine ductal carcinoma.

Cutis 2018 May;101(5):378;380;385

Hartford Dermatology Associates, West Hartford, Connecticut, USA.

Squamoid eccrine ductal carcinoma (SEDC) is an extremely rare cutaneous tumor of unknown etiology. We report the case of a 77-year-old man with a history of treated chronic lymphocytic leukemia along with numerous basal cell and squamous cell carcinomas who presented for evaluation of a 5-cm, stellate, sclerotic plaque on the left chest of approximately 2 years' duration and a suspicious 3-mm pink papule on the right nasal sidewall of 2 months' duration. Initial histology of both lesions revealed carcinoma with squamous and ductal differentiation that extended from the undersurface of the epidermis, favoring a diagnosis of SEDC. Read More

View Article

Perianal basal cell carcinoma treated with Mohs micrographic surgery.

Cutis 2018 May;101(5):362;365;366

Adult and Pediatric Dermatology, PC, Concord, Massachusetts, USA.

Perianal basal cell carcinoma (BCC) is a rare lesion that accounts for less than 0.08% of all BCCs. It is challenging to diagnose, as it can be overlooked or mistaken for an inflammatory dermatosis. Read More

View Article

Long-term topical corticosteroid use and risk of skin cancer: a systematic review.

JBI Database System Rev Implement Rep 2018 Jun;16(6):1387-1397

The Nottingham Centre for Evidence-Based Healthcare: a Joanna Briggs Institute Centre of Excellence.

Objective: The objective of this systematic review was to synthesize available research evidence to determine the risk of skin cancer in patients with long-term use of topical corticosteroids (TCS).

Introduction: Topical corticosteroids are one of the most commonly prescribed medicines in dermatology and the mainstay of the treatment of atopic dermatitis and other skin conditions such as psoriasis. They are often required for months or years to control the disease and ultimately restore patients' quality of life. Read More

View Article
June 2018
2 Reads

A novel association between core mutations in hepatitis B virus genotype F1b and hepatocellular carcinoma in Alaskan Native People.

Hepatology 2018 Jun 12. Epub 2018 Jun 12.

Department of Virology & Liver Unit, Nagoya City University Graduate School of Medical Science, Nagoya, Japan.

Hepatitis B virus (HBV) genotype F1b infection is strongly associated with hepatocellular carcinoma (HCC) in young Alaskan Native (AN) people. However, the mechanisms by which genotype F1b causes HCC are unclear. Here, we analyzed the clinical and virological significance of genotype F1b in long-term serial samples from 20 HCC patients with HBV infection. Read More

View Article

The relevance of a suppressor of fused (SUFU) mutation in the diagnosis and treatment of Gorlin syndrome.

JAAD Case Rep 2018 Mar 2;4(2):196-199. Epub 2018 Feb 2.

Keck School of Medicine at the University of Southern California, Los Angeles, California.

View Article

Focal dermal hypoplasia: A novel finding in disguise.

J Oral Biol Craniofac Res 2018 May-Aug;8(2):143-146. Epub 2018 Feb 1.

Department of Oral and Maxillofacial Surgery, Luton and Dunstable University Hospital, Lewsey Road, Luton, LU4 0DZ, United Kingdom.

Focal Dermal Hypoplasia (FDH) or Goltz-Gorlin syndrome is an unusual X-linked dominant syndrome characterised by anomalies of both ectodermal and mesodermal structures. We present a case report on the management of a 58 year old Caucasian male with Focal Dermal Hypoplasia. This report describes an additional clinical manifestation of an intraosseous mandibular lipoma, which has not been previously described in cases of FDH. Read More

View Article
February 2018

From chemo-prevention to epigenetic regulation: The role of isothiocyanates in skin cancer prevention.

Pharmacol Ther 2018 Jun 8. Epub 2018 Jun 8.

Department of Applied Sciences, Northumbria University, Newcastle Upon Tyne, UK. Electronic address:

Skin cancer incidence is rapidly growing over the last decades and is generally divided into malignant melanoma and non-melanoma (NMSC) with the latter being subdivided into squamous (SCC) and basal cell carcinoma (BCC). Among them, melanoma is the most aggressive type with high mortality rates. On the other hand, aberrant gene expression is a critical step towards malignant transformation. Read More

View Article

Medical Students' Knowledge, Attitudes, and Behaviors With Regard to Skin Cancer and Sun Protective Behaviors.

J Am Osteopath Assoc 2018 Jun 11. Epub 2018 Jun 11.

Background: Skin cancer is the most prevalent cancer in the United States. Training medical students about the importance of sun-protective behaviors is critical to reducing skin cancer rates. However, minimal research has explored osteopathic medical students' knowledge and behaviors with regard to the sun's effect on skin health. Read More

View Article
June 2018
1 Read

Conventional and combination topical photodynamic therapy for basal cell carcinoma: systematic review and meta-analysis.

Br J Dermatol 2018 Jun 11. Epub 2018 Jun 11.

Photobiology Unit, Dermatology Centre, The University of Manchester, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.

Background: Topical photodynamic therapy (PDT) is an established treatment option for low-risk basal cell carcinoma (BCC).

Objectives: Compare efficacy, cosmesis and tolerability of PDT for BCC with alternative treatments.

Methods: MEDLINE/PubMed/EMBASE/CENTRAL databases were searched from inception until 1 September 2017. Read More

View Article
June 2018
1 Read

Merkel cell polyomavirus Integration-PCR in bilateral metachronous Merkel cell carcinoma on the nose.

J Eur Acad Dermatol Venereol 2018 Jun 11. Epub 2018 Jun 11.

Department of Dermatology, Venerology and Allergology, University Medical Center Ruprecht-Karls-University, Heidelberg, Germany.

An 81-year-old woman presented with a several weeks history of an erythematous tumour at her right nostril (Figure 1a). The tumour was surgically removed. Histopathology showed peritumoral clefts and BerEP4-expression consistent with basal cell carcinoma (Figure 2a). Read More

View Article

[Complications with surgical treatment of basal cell carcinomas in individuals over 75 years of age: A retrospective study of prognostic factors in 158 cases].

Ann Chir Plast Esthet 2018 Jun 7. Epub 2018 Jun 7.

Service de chirurgie plastique réparatrice et esthétique, CHU Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France. Electronic address:

Introduction: Basal cell carcinoma (BCC) is a pathology that evolves locally and it is common in elderly subjects whose frailty could restrict the indications for the reference treatment, which is based on surgery. The aim of this study was to investigate the morbidity and the mortality associated with surgical treatment of BCC in patients over 75 years of age, so as to identify possible prognostic factors for postoperative complications.

Materials And Methods: This was a retrospective study carried out with patients over 75 years of age who were treated surgically for one or several BCC between 2010 and 2015 in the reconstructive and cosmetic plastic surgery unit of the Saint-Louis Hospital in Paris (France). Read More

View Article

Risk of Melanoma With Phosphodiesterase Type 5 Inhibitor Use Among Patients With Erectile Dysfunction, Pulmonary Hypertension, and Lower Urinary Tract Symptoms.

J Sex Med 2018 Jun 5. Epub 2018 Jun 5.

Department of Urology, Stanford University School of Medicine, Stanford, CA, USA. Electronic address:

Background: Phosphodiesterase type 5 inhibitors (PDE5is), a treatment for erectile dysfunction, pulmonary hypertension (pHTN), and lower urinary tract symptoms (LUTS), have been implicated in melanoma development.

Aim: We sought to determine the association between PDE5i use and melanoma development among patients with erectile dysfunction, pHTN, and LUTS.

Methods: This was a retrospective cohort study of subjects contained within the Truven Health MarketScan claims database, which provides information on insurance claims in the United States for privately insured individuals, from 2007-2015. Read More

View Article
June 2018
1 Read

Comedonecrosis Revisited: Strong Association With Intraductal Carcinoma of the Prostate.

Am J Surg Pathol 2018 Jun 6. Epub 2018 Jun 6.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.

From the advent of the Gleason grading system for prostate cancer, cancer displaying intraluminal necrotic cells and/or karyorrhexis within cribriform/solid architecture, a phenomenon termed "comedonecrosis," has been assigned pattern 5. Intraductal carcinoma (IDC-P) shows morphologic overlap with high-grade cribriform/solid adenocarcinoma architecturally and cytologically and may also show central necrosis, yet due to the presence of basal cells at the duct periphery is not currently assigned a grade in clinical practice. On the basis of observations from routine clinical cases, we hypothesized that comedonecrosis was more significantly associated with IDC-P than invasive disease. Read More

View Article

Change in Eyelid Carcinoma T Category With Use of the 8th Versus 7th Edition of the American Joint Committee on Cancer: Cancer Staging Manual.

Ophthalmic Plast Reconstr Surg 2018 Jun 5. Epub 2018 Jun 5.

Orbital Oncology and Ophthalmic Plastic Surgery, Department of Plastic Surgery.

Purpose: To evaluate the frequency and nature of changes in T category when eyelid carcinomas are staged using the criteria in the 8th edition instead of the 7th edition of the American Joint Committee on Cancer staging manual.

Methods: Following Institutional Review Board approval, a retrospective review was conducted for all consecutive patients with the diagnosis of eyelid carcinoma treated by the senior author from January 2012 through December 2016. After a review of the clinical and pathologic data, each patient's disease was staged using both the 7th-edition and 8th-edition American Joint Committee on Cancer criteria for eyelid carcinomas. Read More

View Article

Malar Reconstruction with Anterior Bilobed Cheek Flap.

Plast Reconstr Surg Glob Open 2018 Apr 13;6(4):e1725. Epub 2018 Apr 13.

Department of Plastic and Reconstructive Surgery, Osaka Medical College, Takatsuki, Japan.

A 66-year-old man had developed a tumor on his right cheek. A biopsy revealed basal cell carcinoma. The ulcerative cancer and zygomatic bone were resected. Read More

View Article

YAP and TAZ are essential for basal and squamous cell carcinoma initiation.

EMBO Rep 2018 Jun 6. Epub 2018 Jun 6.

Laboratory of Stem Cells and Cancer, Université Libre de Bruxelles, Brussels, Belgium

YAP and TAZ are key downstream regulators of the Hippo pathway, regulating cell proliferation and differentiation. YAP and TAZ activation has been reported in different cancer types. However, it remains unclear whether they are required for the initiation of major skin malignancies like basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Read More

View Article
June 2018
1 Read

Differential diagnostic significance of epithelial and stromal CD10 expression in tumors of trichogenic origin.

J Dtsch Dermatol Ges 2018 Jun;16(6):719-728

Department of Dermatology, Venereology and Allergology, University Medical Center, Würzburg, Germany.

Background And Objectives: The histological differential diagnosis between benign trichogenic skin tumors and basal cell carcinoma may be challenging. We therefore set out to investigate whether expression of CD10, a cell surface protein with neutral endopeptidase activity, might be a suitable marker for the histological differential diagnosis of trichogenic skin tumors.

Patients And Methods: We immunohistochemically analyzed 119 cases of benign trichogenic skin tumors and basal cell carcinoma. Read More

View Article

New biochip immunofluorescence test for the serological diagnosis of pemphigus vulgaris and foliaceus: A review of the literature.

Int J Womens Dermatol 2018 Jun 3;4(2):102-108. Epub 2018 Feb 3.

Department of Dermatology, St George Hospital, Sydney, New South Wales, Australia.

The immunoassays that are available for the serological diagnosis of the more common subtypes of autoimmune blistering diseases such as pemphigus vulgaris (PV) and pemphigus foliaceus (PF) include enzyme-linked immunosorbent assay (ELISA) testing to specific antigens desmoglein (Dsg)1 and Dsg3, direct immunofluorescence (DIF), indirect immunofluorescence (IIF), and immunoblotting. A review of the literature on the biochip assay was conducted. Six studies investigated the validity of a new biochip, mosaic-based, IIF test in patients with pemphigus and demonstrated its relatively high sensitivity and specificity (Dsg3: 97. Read More

View Article

Patched-2 functions to limit Patched-1 deficient skin cancer growth.

Cell Oncol (Dordr) 2018 Jun 4. Epub 2018 Jun 4.

Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam and Academic Medical Center, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands.

Purpose: Basal cell carcinoma (BCC) is one of the most common skin cancers, and is typically driven by an aberrantly activated Hedgehog (Hh) pathway. The Hh pathway is regulated by interactions between the Patched-1 (Ptch1) and Smoothened (Smo) receptors. Smo is an activating receptor and is subject to inhibition by Ptch1. Read More

View Article
June 2018
1 Read

Distinguishing malignant from benign microscopic skin lesions using desorption electrospray ionization mass spectrometry imaging.

Proc Natl Acad Sci U S A 2018 Jun 4;115(25):6347-6352. Epub 2018 Jun 4.

Department of Chemistry, Stanford University, Stanford, CA 94305;

Detection of microscopic skin lesions presents a considerable challenge in diagnosing early-stage malignancies as well as in residual tumor interrogation after surgical intervention. In this study, we established the capability of desorption electrospray ionization mass spectrometry imaging (DESI-MSI) to distinguish between micrometer-sized tumor aggregates of basal cell carcinoma (BCC), a common skin cancer, and normal human skin. We analyzed 86 human specimens collected during Mohs micrographic surgery for BCC to cross-examine spatial distributions of numerous lipids and metabolites in BCC aggregates versus adjacent skin. Read More

View Article

Ophthalmomyiasis in a case of basal cell carcinoma of eyelid.

BMJ Case Rep 2018 Jun 4;2018. Epub 2018 Jun 4.

Neurology, Vinayaka Neuro Multispecialty Clinic, Warangal, India.

Ocular myiasis is a rare disease with invasion of the lids, conjunctiva, cornea and, rarely, orbit or globe of the mammalian eye by dipteral larvae.We report a case of a 74-year-old woman with chronic, infiltrating, ulcerative lesion of the left lower eyelid, which was confirmed as basal cell carcinoma subsequently, having ophthalmomyiasis.She was a destitute, living in unhygienic environmental conditions and having poor general health. Read More

View Article
June 2018
2 Reads

Automated Dermatological Diagnosis: Hype or Reality?

J Invest Dermatol 2018 Jun 1. Epub 2018 Jun 1.

Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:

View Article

Interpretation of the Outputs of Deep Learning Model trained with Skin Cancer Dataset.

J Invest Dermatol 2018 Jun 1. Epub 2018 Jun 1.

Department of Dermatology, Asan Medical Center, Ulsan University College of Medicine, Seoul, Korea. Electronic address:

View Article

Intradermal delivery of a near infrared photosensitiser using dissolving microneedle arrays.

J Pharm Sci 2018 Jun 1. Epub 2018 Jun 1.

Queen's University Belfast, School of Pharmacy, Medical Biology Centre, 97 Lisburn Road, Belfast, BT9 7BL, United Kingdom. Electronic address:

Nodular basal cell carcinoma is a deep skin lesion and one of the most common cancers. Conventional photodynamic therapy (PDT) is limited to treatment of superficial skin lesions. The parenteral administration of near infrared (NIR) preformed photosensitisers suffers from poor selectivity and may result in prolonged skin photosensitivity. Read More

View Article

Basal-Cell Carcinoma With Matrical Differentiation: Report of a New Case in a Renal-Transplant Recipient and Literature Review.

Am J Dermatopathol 2018 Jun 1. Epub 2018 Jun 1.

Departments of Dermatology, and.

Basal-cell carcinoma with matrical differentiation (BCC-MD) is one of the rarest pathologic variants of basal-cell carcinoma, of which 41 cases have been so far reported in detail. One of them developed in a heart-transplant recipient. We report a new case of BCC-MD occurring in a renal-transplant recipient and review the relevant literature. Read More

View Article
June 2018
2 Reads