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    [Proliferation of a basal cell carcinoma on a sebaceous nevus of the lower eyelid: Case report of a rare association].
    J Fr Ophtalmol 2017 Oct 12. Epub 2017 Oct 12.
    Service d'ophtalmologie B de l'hôpital des spécialités, université Mohammed V Souissi, centre hospitalier universitaire, avenue des Nations Unies, Agdal, Rabat, Maroc.

    Spectrum of orocutaneous disease associations: Genodermatoses and inflammatory conditions.
    J Am Acad Dermatol 2017 Nov;77(5):809-830
    Division of Dermatology, Baylor University Medical Center, Dallas, Texas. Electronic address:
    The oral cavity and cutaneous organ systems share a close embryologic origin. Therefore, there are numerous dermatologic conditions presenting with concomitant oral findings of which the dermatologist must be aware. The second article in this continuing medical education series reviews inflammatory orocutaneous conditions and a number of genodermatoses. Read More

    Establishment of oral squamous cell carcinoma cell line and magnetic bead-based isolation and characterization of its CD90/CD44 subpopulations.
    Oncotarget 2017 Sep 3;8(39):66254-66269. Epub 2017 Aug 3.
    Department of Physiology, Faculty of Medicine, Masaryk University, CZ-62500 Brno, Czech Republic.
    In this study, we describe the establishment of the human papillomavirus 18-positive, stage II, grade 1, T2N0M0 head and neck tumor primary cell line derived from oral squamous cell carcinoma of a non-smoking patient by using two different protocols. Furthermore, a preparation of subpopulations derived from this primary cell line according to the cluster of differentiation molecules CD44/CD90 status using magnetic bead-based separation and their characterization was performed. Impedance-based real-time cell analysis, enzyme-linked immunsorbant assay (ELISA), wound-healing assay, flow-cytometry, gene expression analysis, and MTT assay were used to characterize these four subpopulations (CD44(+)/CD90(-), CD44(-)/CD90(-), CD44(+)/CD90(+), CD44(-)/CD90(-)). Read More

    Dopamine-induced SULT1A3/4 promotes EMT and cancer stemness in hepatocellular carcinoma.
    Tumour Biol 2017 Oct;39(10):1010428317719272
    International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China.
    Hepatocellular carcinoma has the second highest incidence rate among malignant cancers in China. Hepatocellular carcinoma development is complex because of the metabolism disequilibrium involving SULT1A3/4, a predominant sulfotransferase that metabolizes sulfonic xenobiotics and endogenous catecholamines. However, the correlation between SULT1A3/4 and hepatocellular carcinoma progression is unclear. Read More

    Human papillomavirus and post-transplant cutaneous squamous-cell carcinoma: a multicenter, prospective cohort study.
    Am J Transplant 2017 Oct 11. Epub 2017 Oct 11.
    Institute of Virology, University of Cologne, Cologne, Germany.
    Organ-transplant recipients (OTR) have a 100-fold increased risk of cutaneous squamous-cell carcinoma (cSCC). We prospectively evaluated the association between beta-genus human-papillomaviruses (betaPV) and keratinocyte carcinoma in OTR. Two OTR cohorts without cSCC were assembled: cohort 1 transplanted in 2003-2006 (n=274) and cohort 2 in 1986-2002 (n=352). Read More

    Effect of a See and Treat clinic on skin cancer treatment time.
    ANZ J Surg 2017 Oct 11. Epub 2017 Oct 11.
    Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.
    Background: Many plastic surgery departments in Australasia have experienced increasing referrals for management of skin lesions. This has driven a demand for new strategies to decrease patient waiting time and administrative costs. The aim of this study was to determine if a purpose-built See and Treat skin cancer clinic could provide a faster skin cancer treatment pathway with comparable clinical outcomes and acceptability to patients. Read More

    Be vigilant for skin manifestations of inherited cancer syndromes.
    Practitioner 2017 01;261(1800):23-7
    More than 200 hereditary cancer susceptibility syndromes have been described, and it is thought that they account for 5-10% of all cancers. Many have dermatological manifestations (usually lesions, occasionally rashes) which frequently precede other systemic pathology. Dermatological signs are usually non-specific and often trivial in appearance, making their significance easy to overlook and a clinical diagnosis challenging. Read More

    The incidence and multiplicity rates of keratinocyte cancers in Australia.
    Med J Aust 2017 Oct;207(8):339-343
    QIMR Berghofer Medical Research Institute, Brisbane, QLD.
    Objectives: To assess the incidence and multiplicity of keratinocyte cancers (basal cell carcinoma [BCC] and squamous cell carcinoma [SCC]) excised in Australia, and to examine variations by age, sex, state, and prior skin cancer history.

    Design: Analysis of individual-level Medicare data for keratinocyte cancer treatments (identified by eight specific MBS item codes) during 2011-2014. Histological data from the QSkin prospective cohort study were analysed to estimate BCC and SCC incidence. Read More

    [Non-melanoma skin cancer : Pathogenesis, prevalence and prevention].
    Hautarzt 2017 Oct 10. Epub 2017 Oct 10.
    Klinik und Poliklinik für Dermatologie und Allergologie am Biederstein, Technische Universität München, Biedersteiner Str. 29, 80802, München, Deutschland.
    Non-melanoma skin cancer (NMSC) is the most common malignancy of the light-skinned population with an enormous socioeconomic impact. Historically known as incurable under the term noli me tangere (transl. do not touch me), today various non-melanocytic cutaneous neoplasms are grouped as NMSC. Read More

    Long-Term Follow-Up Results of Topical Imiquimod Treatment in Basal Cell Carcinoma.
    Dermatol Surg 2017 Oct 6. Epub 2017 Oct 6.
    Departments of *Dermatology, and †Pathology, Faculty of Medicine, Ankara University, Ankara, Turkey; S. Vural is currently affiliated with the Dermatology and Allergology Department, Ludwig Maximilian University, München, Germany.
    Background: Imiquimod 5% topical cream is approved for treatment of superficial basal cell carcinoma (BCC). Data on the long-term efficacy and usage in other BCC subtypes are scarce.

    Objective: Evaluation of long-term safety and efficacy of topical imiquimod treatment in various BCC subtypes and locations, with individualized treatment duration. Read More

    Color Doppler Ultrasound Supports Early Diagnosis of Mixed High and Low Risk of Recurrence Subtypes in the Same Basal Cell Carcinoma Lesion.
    Dermatol Surg 2017 Oct 6. Epub 2017 Oct 6.
    Department of Dermatology, Faculty of Medicine, University of Chile, Santiago, Chile Department of Dermatology, Faculty of Medicine, University of Chile, Santiago, Chile, Department of Imaging, IDIEP (Institute for Diagnostic Imaging and Research of the Skin and Soft Tissues), Santiago, Chile Department of Dermatology, Faculty of Medicine, University of Chile, Santiago, Chile Department of Pathology, Dermopathology Section, Histodiagnóstico Malaga, Santiago, Chile.

    Managing actinic keratosis in primary care.
    Practitioner 2016 10;260(1797):25-9
    Actinic, or solar, keratosis is caused by chronic ultraviolet-induced damage to the epidermis. In the UK, 15-23% of individuals have actinic keratosis lesions. Risk factors include: advanced age; male gender; cumulative sun exposure or phototherapy; Fitzpatrick skin phototypes I-II; long-term immuno-suppression and genetic syndromes e. Read More

    Macrophage subtypes in recurrent nodular basal cell carcinoma after Mohs micrographic surgery.
    Int J Dermatol 2017 Oct 9. Epub 2017 Oct 9.
    Departments of Pathology and Dermatology, University of São Paulo Medical School, São Paulo, Brazil.
    Background: The macrophages associated with solid tumors are related to the progression or regression of tumors, depending on the differentiation in M1 or M2. M2 subtype promotes angiogenesis, remodeling, and tissue repair (tumor proliferation). In contrast, M1 produces toxic mediators and presents antigens, destroying microorganisms and tumor cells. Read More

    Epidemiology of keratinocyte carcinomas after organ transplantation.
    Br J Dermatol 2017 Oct 10. Epub 2017 Oct 10.
    QIMR Berghofer Medical Research Institute, Queensland, Australia.
    Keratinocyte carcinoma (KC) is the most common type of cancer among white populations, but it is even more common among solid organ transplant recipients (OTRs). The most frequent histological type of KC among OTRs is cutaneous squamous cell carcinoma (cSCC), followed by basal cell carcinoma, although the reverse is seen in the general population. Metastatic cSCCs are more frequent, and mortality is increased compared with immunocompetent populations. Read More

    Cell Cycle-dependent Tumor Engraftment and Migration are Enabled by Aurora A.
    Mol Cancer Res 2017 Oct 9. Epub 2017 Oct 9.
    Pediatrics, University of British Columbia
    Cell cycle progression and the acquisition of a migratory phenotype are hallmarks of human carcinoma cells that are perceived as independent processes but may be interconnected by molecular pathways that control microtubule nucleation at centrosomes. Here, cell cycle progression dramatically impacts the engraftment kinetics of 4T1-luciferase2 breast cancer cells in immunocompetent BALB/c or immunocompromised NOD-SCID gamma (NSG) mice. Multi-parameter imaging of wound closure assays was used to track cell cycle progression, cell migration, and associated phenotypes in epithelial cells or carcinoma cells expressing a fluorescence ubiquitin cell cycle indicator. Read More

    [SOP - Standarized procedures in diagnostics and therapies of periocular basal cell carcinoma].
    Klin Monbl Augenheilkd 2017 Oct 9. Epub 2017 Oct 9.
    The basal cell carcinoma (BCC) is the malignant eye tumor with the highest incidence. The aim of this article is to present a systematic and standardized approach to diagnose, treat and care periocular basal cell carcinoma. Interpretation of clinical signs, diagnostic tools to identify periocular BCC and interpretation lead to the appropriate choice of therapy. Read More

    Slug/Pcad pathway controls epithelial cell dynamics in mammary gland and breast carcinoma.
    Oncogene 2017 Oct 9. Epub 2017 Oct 9.
    Institut de Recherche en Cancérologie de Montpellier (IRCM), Inserm U1194, Université de Montpellier, Institut Régional du Cancer de Montpellier (ICM), Montpellier, France.
    Mammary gland morphogenesis results from the coordination of proliferation, cohort migration, apoptosis and stem/progenitor cell dynamics. We showed earlier that the transcription repressor Slug is involved in these functions during mammary tubulogenesis. Slug is expressed by a subpopulation of basal epithelial cells, co-expressed with P-cadherin (Pcad). Read More

    Simultaneous visualization of the subfemtomolar expression of microRNA and microRNA target gene using HILO microscopy.
    Chem Sci 2017 Sep 31;8(9):6670-6678. Epub 2017 Jul 31.
    Department of Chemistry , Tunghai University , Taichung 407 , Taiwan . Email:
    The family of microRNAs (miRNAs) not only plays an important role in gene regulation but is also useful for the diagnosis of diseases. A reliable method with high sensitivity may allow researchers to detect slight fluctuations in ultra-trace amounts of miRNA. In this study, we propose a sensitive imaging method for the direct probing of miR-10b (miR-10b-3p, also called miR-10b*) and its target (HOXD10 mRNA) in fixed cells based on the specific recognition of molecular beacons combined with highly inclined and laminated optical sheet (HILO) fluorescence microscopy. Read More

    Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer.
    Cell 2017 Oct 4. Epub 2017 Oct 4.
    Scott Department of Urology, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:
    We report a comprehensive analysis of 412 muscle-invasive bladder cancers characterized by multiple TCGA analytical platforms. Fifty-eight genes were significantly mutated, and the overall mutational load was associated with APOBEC-signature mutagenesis. Clustering by mutation signature identified a high-mutation subset with 75% 5-year survival. Read More

    Cancer associated fibroblasts (CAFs) are activated in cutaneous basal cell carcinoma and in the peritumoural skin.
    BMC Cancer 2017 Oct 7;17(1):675. Epub 2017 Oct 7.
    Department of Dermato-Venerology, Bispebjerg University Hospital, Bispebjerg Bakke 23, 2400, Copenhagen, Nordvest, Denmark.
    Background: Cutaneous basal cell carcinoma (BCC) is the commonest cancer worldwide. BCC is locally invasive and the surrounding stromal microenvironment is pivotal for tumourigenesis. Cancer associated fibroblasts (CAFs) in the microenvironment are essential for tumour growth in a variety of neoplasms but their role in BCC is poorly understood. Read More

    Osseointegrated Prosthetic Ear Reconstruction in Cases of Skin Malignancy: Technique, Outcomes, and Patient Satisfaction.
    Ann Plast Surg 2017 Oct 3. Epub 2017 Oct 3.
    From the *Division of Plastic Surgery, University of Utah, Salt Lake City, UT; †Division of Plastic and Reconstructive Surgery, Stanford Hospital and Clinics, Stanford, CA; ‡Huntsman Cancer Institute; and §Division of General Surgery, University of Utah, Salt Lake City, UT.
    Background: Ear reconstruction with osseointegrated prosthetic implants is a well-established method of reconstruction after resection of skin malignancies on the external ear. There is limited literature reporting technique, outcomes, and patient satisfaction.

    Methods: We evaluated our outcomes over a 5-year period looking at osseointegrated prosthetic reconstruction after auriculectomy for external ear skin malignancies. Read More

    Photodynamic Therapy Using Indolines-Fused-Triazoles Induces Mitochondrial Apoptosis in Human Non-Melanoma BCC Cells.
    Anticancer Res 2017 10;37(10):5499-5505
    Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung, Taiwan, R.O.C.
    Background/aim: Cancer is one of the most dreadful diseases in humans and among them non-melanoma skin cancer (NMSC) is an increasing problem in the world, that occurs more frequently in people with fair skin. Photodynamic therapy (PDT), a non-invasive treatment is widely used for the prevention and treatment of BCC cells. We previously reported an efficient synthesis of novel indolines-fused-triazoles and studied their photophysical studies. Read More

    [Zitelli bilobed flap for the reconstruction of the nasal pyramid after excision of basal cell carcinoma (BCC)].
    Pan Afr Med J 2017 2;27:238. Epub 2017 Aug 2.
    Service Chirurgie Plastique, Brûlés et Chirurgie de la Main, Hôpital Avicenne, Rabat, Maroc.
    We report the case of a 65-year old patient presenting with well-defined nodular basal cell carcinom measuring 5mm in diameter in the right paramedian nasal tip and the superior margin of the nasal wing, near the free edge. The tumor was removed, with resection margin of 1mm. It was associated with multiple hyperkeratotic lesions spread across his face. Read More

    Structured zinc oxide dressing for secondary intention wounds.
    J Wound Care 2017 Oct;26(Sup10):S30-S36
    S&A Technologies, LLC, Rolla, MO, US.
    Objective: Inexpensive methods for more rapid healing of secondary intention wounds are sought. This pilot study measured the wound healing rate for a new zinc oxide structured dressing technique.

    Method: In this study, we included the three patients with the largest wounds with onset during a one month period. Read More

    Epigenetics of Skin Cancer: Interventions by selected bioactive Phytochemicals.
    Photodermatol Photoimmunol Photomed 2017 Oct 4. Epub 2017 Oct 4.
    Laboratory of Cancer Epigenetics, Department of Biochemistry, CSIR-Central Food Technological Research Institute, Mysore, India.
    The prevalence and risk of skin cancer have been increasing over past three decades. Two major types of skin cancer observed in humans are melanoma and non-melanoma. Non-melanoma further subdivided into basal cell carcinoma and squamous cell carcinoma. Read More

    Local immune response in cutaneous basal cell carcinoma.
    Dan Med J 2017 Oct;64(10)
    BCC is an immunogenic tumor highlighted by the increased risk in immunosuppressed individuals and the frequent occurrence of tumor infiltrating lymphocytes (TILs) in the tumor surroundings. Immunotherapy is evolving as a promising treatment strategy for several cancer types where topical immunostimulators are among the possibilities for superficial BCC. The overall aim of this thesis is to characterize the immunologic response upon BCC as well as characterizing the surrounding tumor stroma. Read More

    MIXED TYPE BASAL CELL CARCINOMA OF THE AURICLE - SINGLE STAGE RECONSTRUCTION AFTER R0-RESECTION BY A MODIFIED ANTIA-BUCH FLAP (CLINICAL CASE REPORT).
    Georgian Med News 2017 Sep(270):7-10
    Clinica Goldman, Porto Alegre, RS, Brazil; Department of Dermatology and Allergology, Academic Teaching Hospital Dresden, Dresden, Germany.
    Basal cell carcinoma (BCC) is the most common neoplasia in Caucasians with a pre-dominance for the sun-exposed anatomical areas including the auricle. The treatment of choice is surgery achieving an R0-resection status. On the other hand, functional and aesthetic results are of importance. Read More

    LEF-1: Diagnostic utility in distinguishing basaloid neoplasms of the salivary gland.
    Diagn Cytopathol 2017 Oct 3. Epub 2017 Oct 3.
    Emory University School of Medicine, Pathology, Atlanta, Georgia.
    Background: Lymphoid enhancer binding factor 1 (LEF-1) has recently been reported as a potential immunohistochemical (IHC) marker for basal cell adenoma (BCA) and other salivary gland tumors, which may contribute to an increased accuracy in differentiating basaloid salivary gland neoplasms. We evaluated the utility of LEF-1 in fine needle aspiration (FNA) and resection specimens to distinguish pleomorphic adenoma (PA), BCA, basal cell adenocarcinoma (BCAC), and adenoid cystic carcinoma (ACC) as well as in non-neoplastic salivary gland (NNSG).

    Methods: Cases including 66 PA (35 FNA, 31 resections), 12 BCA (5 FNA, 7 resections), 42 ACC (11 FNA, 31 resections), 1 BCAC FNA, and 10 NNSG (5 FNA, 5 resections) were obtained and stained for LEF-1. Read More

    Chemoprevention of Skin Carcinomas in High-Risk Transplant Recipients.
    Curr Med Chem 2017 Oct 3. Epub 2017 Oct 3.
    San Raffaele Scientific Institute, Vita Salute San Raffaele University, v. Olgettina 58, 20132 Milano. Italy.
    Long-term immunosuppressive therapy, as provided to solid organ transplant recipients, inevitably results in a significant inhibition of immune defenses; this leads to frequent skin infections and malignancies, which represent an important cause of morbidity and mortality for transplanted patients. The incidence and risk of skin carcinomas are elevated in solid organ transplant recipients in comparison with the general population, with a 10-fold increased risk for basal cell carcinoma and a 50-100-fold for squamous cell carcinoma. The schedule of immunosuppressive drugs influences the type and timing of skin malignancies, but a crucial role is also played by endogenous and exogenous risk factors. Read More

    Skin Cancer Epidemics in the Elderly as An Emerging Issue in Geriatric Oncology.
    Aging Dis 2017 Oct 1;8(5):643-661. Epub 2017 Oct 1.
    1Institute of Dermatology, Policlinico A. Gemelli University Hospital, Catholic University of the Sacred Heart, Rome, Italy.
    Skin cancer is a worldwide, emerging clinical need in the elderly white population, with a steady increase in incidence rates, morbidity and related medical costs. Skin cancer is a heterogeneous group of cancers comprising cutaneous melanoma and non-melanoma skin cancers (NMSC), which predominantly affect elderly patients, aged older than 65 years. Melanoma has distinct clinical presentations in the elderly patient and represents a challenging question in terms of clinical management. Read More

    DIP2C expression in breast cancer and its clinical significance.
    Pathol Res Pract 2017 Sep 12. Epub 2017 Sep 12.
    Huzhou Key Laboratory of Molecular Medicine, Huzhou Central Hospital, Huzhou, 313000, China. Electronic address:
    Introduction: The aim of this study was to investigate DIP2C expression in different subtypes of breast cancer tissues and cell lines and its correlation with clinicopathologic and histopathological features, in an effort to elucidate the DIP2C expression profile in breast cancer and its clinical significance.

    Methods: Hereby, we investigated the DIP2C expression in breast cancer tissues using TMA-IHC method and the DIP2C expression in breast cell lines using quantitative RT-PCR.

    Results: DIP2C displayed universal expression, being present in all the breast cancer subtypes. Read More

    Use of reflectance confocal microscopy to evaluate 5-fluorouracil 0.5% /salicylic acid 10% in the field-directed treatment of sub-clinical lesions of actinic keratosis: sub-analysis of a Phase III, randomised, double-blind, vehicle-controlled trial.
    J Eur Acad Dermatol Venereol 2017 Sep 28. Epub 2017 Sep 28.
    Department of Dermatology, Ruhr-University, Bochum, Germany.
    Background: Actinic keratosis (AK) is a common skin disorder that can progress to invasive squamous-cell carcinoma. AK can present as clinical (visible) or sub-clinical (invisible) lesions within areas of chronic sun damage. The importance of treating sub-clinical AK is gaining support. Read More

    Primary Large Cell Neuroendocrine Carcinoma of the Skin: An under-recognized entity and a mimic of metastatic disease.
    J Cutan Pathol 2017 Sep 28. Epub 2017 Sep 28.
    Department of Pathology and Laboratory Medicine, Nova Scotia Health Authority (central Zone), Halifax, NS, B3H 1V8, Canada.
    Primary large cell neuroendocrine carcinomas of the skin are exceptionally rare and can be diagnosed only when a metastasis from another organ has been excluded. We report the case of a 62 year old woman with a cutaneous papule on the mid-chest which generated a differential diagnosis of vascular lesion and basal cell carcinoma. Following excision, microscopic evaluation revealed a dermal large cell undifferentiated carcinoma, with a brisk mitotic rate and focal geographic necrosis. Read More

    Molecular basis of basal cell carcinoma.
    An Bras Dermatol 2017 Jul-Aug;92(4):517-520
    Research Center of the Clínica Dermatológica Santa Catarina - João Pessoa (PB), Brazil.
    Basal cell carcinoma is the most common cancer, presenting low mortality but high morbidity, and it has as risk factor exposure to sunlight, especially UVB spectrum. The most important constitutional risk factors for basal cell carcinoma development are clear phototypes (I and II, Fitzpatrick classification), family history of basal cell carcinoma (30-60%), freckles in childhood, eyes and light hair. The environmental risk factor better established is exposure to ultraviolet radiation. Read More

    Study of factors affecting the incidence of skin cancer in patients after liver transplant.
    An Bras Dermatol 2017 Jul-Aug;92(4):492-498
    Department of Pathologic Anatomy of School of Medical Sciences of Universidade Estadual de Campinas (FCM-Unicamp) - Campinas (SP), Brazil.
    Background:: Many factors are currently being identified as potential inductors of skin cancer in patients after a liver transplant, among them, immunosuppressive regimen.

    Objective:: To study the factors that influence the incidence of skin cancer in patients after liver transplant.

    Methods:: We have carried out a retrospective and observational study with 170 transplanted patients who had undergone transplantation from 1997 to 2010. Read More

    Development and Validation of the Basal and Squamous Cell Carcinoma Quality of Life Questionnaire.
    Acta Derm Venereol 2017 Sep 27. Epub 2017 Sep 27.
    Department of Dermatology, Erasmus MC University Medical Centre, Postbus 2040, NL-3000 CA Rotterdam, The Netherlands.
    Health-related quality of life (HRQoL) is important in the management of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Disease-specific questionnaires exist, but with important shortcomings. The aim of this study was to develop and validate a questionnaire suitable for use in all patients with BCC and those with SCC. Read More

    Risk prediction tools for keratinocyte carcinoma after solid organ transplantation: a review of the literature.
    Br J Dermatol 2017 Sep 26. Epub 2017 Sep 26.
    Department of Dermatology, University of California at San Francisco, San Francisco, CA, U.S.A.
    Long-term iatrogenic immunosuppression increases the risk of cutaneous malignancies in organ transplant recipients (OTRs), particularly the keratinocyte cancers basal cell carcinoma and cutaneous squamous cell carcinoma (cSCC). cSCC is the most common malignancy in OTRs, with the risk increased to over 65-fold in transplanted patients relative to the general population. There have been very few risk prediction tools developed for accurate determination of the risk of developing keratinocyte cancers in the OTR population. Read More

    Immunofluorescence and confocal microscopy for ex-vivo diagnosis of melanocytic and non-melanocytic skin tumors: a pilot study.
    J Biophotonics 2017 Sep 26. Epub 2017 Sep 26.
    Department of Dermatology and Allergy, University Hospital, LMU Munich, Germany.
    Background: Ex-vivo confocal laser scanning microscopy (ex-vivo CLSM) offers rapid examination of freshly excised tissue. During the conventional examination immunohistochemistry enables to distinguish various cell types. The possibility of immunofluorescent techniques could enhance the accuracy of the diagnosis performed by ex-vivo CLSM. Read More

    NUT Midline Carcinoma: A Series of Five Cases, Including One with Unusual Clinical Course.
    Head Neck Pathol 2017 Sep 25. Epub 2017 Sep 25.
    Department of Pathology, All India Institute of Medical Sciences, New Delhi, 110029, India.
    NUT midline carcinomas (NMCs) are rare, poorly differentiated tumors with aggressive biological behavior and a characteristic molecular signature. Availability of NUT antibody has facilitated diagnosis of NMC without molecular testing. We report a series of head and neck NMCs diagnosed using NUT IHC at our institute, including one case with an unusual course. Read More

    Hormonal and reproductive factors and incidence of basal cell carcinoma and squamous cell carcinoma in a large, prospective cohort.
    J Am Acad Dermatol 2017 Sep 22. Epub 2017 Sep 22.
    Department of Population Health, QIMR Berghofer Medical Research Institute, Queensland, Australia; School of Public Health, University of Queensland, Queensland, Australia.

    Mechanisms of CXCR7 induction in malignant melanoma development.
    Oncol Lett 2017 Oct 4;14(4):4106-4114. Epub 2017 Aug 4.
    Institute of Dermatology, Chinese Academy of Medical Sciences, Nanjing, Jiangsu 210042, P.R. China.
    Malignant melanoma (MM) is a highly malignant skin tumor. The mechanism of MM pathogenesis and its signaling pathways are not well characterized. C-X-C chemokine receptor type 7 (CXCR7) has been reported to regulate cancer cell invasion. Read More

    A pathways-based prediction model for classifying breast cancer subtypes.
    Oncotarget 2017 Aug 17;8(35):58809-58822. Epub 2017 Jun 17.
    Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Heilongjiang Province, China.
    Breast cancer is highly heterogeneous and is classified into four subtypes characterized by specific biological traits, treatment responses, and clinical prognoses. We performed a systemic analysis of 698 breast cancer patient samples from The Cancer Genome Atlas project database. We identified 136 breast cancer genes differentially expressed among the four subtypes. Read More

    A Case of Phacomatosis Pigmentokeratotica Associated With Multiple Basal Cell Carcinomas.
    Am J Dermatopathol 2017 Sep 13. Epub 2017 Sep 13.
    Department of Dermatology, College of Medicine, Kyung Hee University, Seoul, Korea.
    Phacomatosis pigmentokeratotica is a recently identified disease characterized by the coexistence of an epidermal nevus with sebaceous differentiation arranged along Blaschko lines and a speckled lentiginous nevus showing a checkerboard pattern, mostly in association with various extracutaneous defects. A 52-year-old man presented with asymptomatic ulcerative plaque on his left side of perioral area. A 2 × 2-cm-sized fleshy colored ulceration on his left perioral area was consistent with basal cell carcinoma with nevus sebaceous. Read More

    Hepatitis C Virus Infection Increases c-Jun N-Terminal Kinase (JNK) Phosphorylation and Accentuates Hepatocyte Lipoapoptosis.
    Med Sci Monit 2017 Sep 21;23:4526-4532. Epub 2017 Sep 21.
    Department of Gastroenterology and Hepatology, Nagasaki University Hospital, Nagasaki City, Nagasaki, Japan.
    BACKGROUND Hepatitis C virus (HCV) infection and metabolic diseases including nonalcoholic steatohepatitis (NASH) exhibit a complex interplay. Although free fatty acid-mediated apoptosis is a prominent feature of NASH, the impact of HCV infection on hepatocyte lipotoxicity has remained largely unexplored. The study aimed at identifying whether infection by HCV affected the apoptotic pathway in hepatocytes during fatty acid assault. Read More

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