28,812 results match your criteria Epitheliomas Basal Cell


Biomarkers of basal cell carcinoma resistance to methyl-aminolevulinate photodynamic therapy.

PLoS One 2019 24;14(4):e0215537. Epub 2019 Apr 24.

Dermatology Service, Hospital Miguel Servet, Zaragoza, Spain.

Background: Methyl-aminolevulinate photodynamic therapy (MAL-PDT) is an excellent option for the treatment of basal cell carcinoma (BCC). However, up to 25% of cases are resistant to this treatment modality.

Objective: The aim of this study was to identify potential biomarkers of BCC response to MAL-PDT. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215537PLOS

The use of black salve for self-treatment of Basal Cell Carcinoma.

Clin Exp Dermatol 2019 Apr 24. Epub 2019 Apr 24.

Department of Dermatology, Royal Victoria Hospital, Belfast, United Kingdom.

BCC is the most common form of cancer in England and Wales and has an increasing incidence. Black salve is an alternative therapy widely available with reported benefits in skin cancer despite a lack of supporting evidence. We report two patients with resolution of clinical BCC following the use of black salve. Read More

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http://dx.doi.org/10.1111/ced.13988DOI Listing

Recognizing Basal Cell Carcinoma on Smartphone-Captured Digital Histopathology Images with Deep Neural Network.

Br J Dermatol 2019 Apr 24. Epub 2019 Apr 24.

Department of Dermatopathology, Institute of Dermatology, Peking Union Medical College& Chinese Academy of Medical Sciences, Nanjing, 210042, China.

Background: Pioneering effort has been made to facilitate the pathology recognition in malignancies based on whole slide images(WSI) through deep learning approaches. It remains unclear whether we can accurately detect and locate BCC using smartphone-captured images.

Objectives: To develop deep neural network frameworks for accurate BCC recognition and segmentation based on smartphone-captured microscopic ocular images (MOI). Read More

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http://dx.doi.org/10.1111/bjd.18026DOI Listing

Photodynamic therapy: A targeted literature review focussing on outcomes and optimisation in solid organ transplant recipients.

Australas J Dermatol 2019 Apr 22. Epub 2019 Apr 22.

Flinders Medical Centre, Bedford Park, South Australia, Australia.

Squamous cell carcinoma incidence is 65- to 250-fold in solid organ transplant recipients, BCC is 10-fold and in Australia, rates of skin cancer in solid organ transplant recipients reach 70-82% prevalence within the first 20 years; hence, effective, evidence-based treatment of early and precancerous lesions is an essential tool in dermatological patient care. Photodynamic therapy is used to treat a range of conditions including actinic keratoses, squamous cell carcinoma in situ, superficial basal cell carcinoma and nodular basal cell carcinoma. A literature review was undertaken to examine the outcomes of photodynamic therapy in solid organ transplant recipients and methods of optimising outcomes in solid organ transplant recipients. Read More

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http://dx.doi.org/10.1111/ajd.13049DOI Listing

Diagnostic value of CD34 and calretinin immunostaining in the diagnosis of proliferating tricholemmal tumor and trichoblastoma.

Int J Dermatol 2019 Apr 23. Epub 2019 Apr 23.

Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.

Background: Proliferating tricholemmal tumor (PTT) is a rare neoplasm of controversial biological behavior for which distinction from other more common tumors is essential. Similarly, trichoblastoma (TB) remains a debatable entity that may represent a variation of basal cell carcinoma (BCC). Our goal is to correlate the staining pattern of calretinin and CD34 in these two follicular tumors vs. Read More

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http://dx.doi.org/10.1111/ijd.14461DOI Listing

Neurofibromatosis Type 1 - Association with Breast Cancer, Basal Cell Carcinoma of the Skin, and Low-Grade Peripheral Nerve Sheath Sarcoma: Case Report and Literature Review.

Case Rep Oncol 2019 Jan-Apr;12(1):228-234. Epub 2019 Mar 5.

Clinical Oncology, Instituto Nacional de Cancerologia, Bogota, Colombia.

Neurofibromatosis type 1 is a rare medical condition that raises the probability of having distinct types of malignant and benign neoplasms. Nevertheless, the association with breast cancer is rare, and metachronic neoplasia with a distinct histologic subtype is an association that has never been reported before. Here we describe a case of a primary breast tumor, with posterior development of basal cell carcinoma of the skin, and a low-grade peripheral nerve sheath sarcoma. Read More

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http://dx.doi.org/10.1159/000496684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465749PMC

Introduction to Skin Cancer: A Video Module.

MedEdPORTAL 2016 Aug 5;12:10431. Epub 2016 Aug 5.

Assistant Professor of Dermatology and Internal Medicine, Harvard Medical School.

Introduction: This introductory skin cancer video module engages novice health care professionals to make histological-clinical correlations for the three most common skin cancers: basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma. The goal of this video module is to engage novice health care professionals (e.g. Read More

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http://dx.doi.org/10.15766/mep_2374-8265.10431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464471PMC

Single visit PDT for basal cell carcinoma - a new therapeutic protocol.

Photodiagnosis Photodyn Ther 2019 Apr 16. Epub 2019 Apr 16.

Skin Department, Foundation Hospital Amaral Carvalho, Jau, São Paulo, Brazil. Electronic address:

Non-melanoma skin cancer is the most prevalent type of cancer in Brazil and worldwide. Topical Photodynamic Therapy is a technique that offers advantages as: excellent aesthetic result, possibility of application for outpatients in ambulatory, and presenting a minimum functional impact of the treated anatomycal site. Fractionated Photodynamic Therapy is a modification of the usual technique in which the full dose of light is delivered in steps separated by a periods of time ("dark intervals"). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15721000193012
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http://dx.doi.org/10.1016/j.pdpdt.2019.04.016DOI Listing
April 2019
1 Read

Nonvascular uses of pulsed dye laser in clinical dermatology.

J Cosmet Dermatol 2019 Apr 19. Epub 2019 Apr 19.

Dermatological Surgery & Laser Unit, St John's Institute of Dermatology, St Thomas' Hospital, London, UK.

Lasers are fast becoming the vogue of dermatology ranging from ablative, nonablative, fractional photothermolysis to vascular lasers. There are a range of vascular lasers including potassium titanyl phosphate (KTP 532 nm), pulsed dye laser (PDL -595 nm), diode (810 nm), and Nd:YAG (1064 nm). PDL is a laser that emits yellow light using Rhodamine dye as it is lasing medium. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jocd.12924
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http://dx.doi.org/10.1111/jocd.12924DOI Listing
April 2019
2 Reads

[Primary basal cell carcinoma of the caruncle].

Ophthalmologe 2019 Apr 18. Epub 2019 Apr 18.

Klinik für Augenheilkunde, Universitätsklinikum Münster, Domagkstr. 15, 48149, Münster, Deutschland.

Background: Primary basal cell carcinoma (BCC) of the caruncle is an extremely rare entity. Overall, only a few cases are described in the literature. With respect to the S2k guidelines on basal cell carcinoma of the skin, the eyelids, eyebrows and periorbital regions are regarded as zones with a high risk of recurrence. Read More

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http://link.springer.com/10.1007/s00347-019-0895-1
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http://dx.doi.org/10.1007/s00347-019-0895-1DOI Listing
April 2019
1 Read

Correction to: Long-term safety and efficacy of vismodegib in patients with advanced basal cell carcinoma: final update of the pivotal ERIVANCE BCC study.

BMC Cancer 2019 04 18;19(1):366. Epub 2019 Apr 18.

Universitätsklinikum Schleswig-Holstein, Schittenhelmstr, 7, D-24 105, Kiel, Germany.

Following publication of the original article [1], it was reported that the legend for Fig. 1 was incomplete. The complete figure legend is. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-019-5568-6DOI Listing
April 2019
1 Read

Advances in the Understanding of Skin Cancer: Ultraviolet Radiation, Mutations, and Antisense Oligonucleotides as Anticancer Drugs.

Molecules 2019 Apr 17;24(8). Epub 2019 Apr 17.

Medical Academy named after S.I. Georgievsky, V.I. Vernadsky Crimean Federal University, Lenin Boulevard 5/7, 295051 Simferopol, Crimea.

Skin cancer has always been and remains the leader among all tumors in terms of occurrence. One of the main factors responsible for skin cancer, natural and artificial UV radiation, causes the mutations that transform healthy cells into cancer cells. These mutations inactivate apoptosis, an event required to avoid the malignant transformation of healthy cells. Read More

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https://www.mdpi.com/1420-3049/24/8/1516
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http://dx.doi.org/10.3390/molecules24081516DOI Listing
April 2019
2 Reads

A novel splicing mutation of PTCH1 in a Chinese family with nevoid basal cell carcinoma syndrome.

Med Mol Morphol 2019 Apr 17. Epub 2019 Apr 17.

Department of Medical Genetics, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.

Nevoid basal cell carcinoma syndrome (NBCCS) is a rare autosomal dominant disease characterized by the development of multiple jaw keratocysts and basal cell carcinomas (BCC) and accompanied by diverse phenotypes. The establishment of diagnosis lies on the identification of a heterozygous germline pathogenic variant in the patched homolog 1 gene (PTCH1). PTCH1 has alternative splicing and selective initial coding exon, leading to three types of encoding proteins (PTCHL, PTCHM and PTCHS). Read More

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http://link.springer.com/10.1007/s00795-019-00222-9
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http://dx.doi.org/10.1007/s00795-019-00222-9DOI Listing
April 2019
2 Reads

Unusual presentation of dermatofibroma on the face: Case report.

Clin Case Rep 2019 Apr 19;7(4):672-674. Epub 2019 Feb 19.

Department of Dermatology, College of Medicine King Khalid University Hospital Riyadh Saudi Arabia.

Dermatofibroma (DF; Benign Fibrous Histiocytoma) seldom presents on the face. We present an unusual case presentation of translucent nodule on the upper right cheek of the face which was diagnosed clinically as basal cell carcinoma. Physician should include DF in the differential of such lesions. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ccr3.2066
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http://dx.doi.org/10.1002/ccr3.2066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452477PMC
April 2019
2 Reads

Synchronous non-collision melanoma and basal cell carcinoma arising from chronic lymphedema: a case report and review of literature.

J Surg Case Rep 2019 Apr 12;2019(4):rjz105. Epub 2019 Apr 12.

Department of General Surgery, Brandon Regional Hospital, Brandon, FL 33511, USA.

Chronic lymphedema (CL) due to failure of lymphatic drainage harbors an immunologically vulnerable environment for the development of various neoplasms. Independently, either melanoma or basal cell carcinoma (BCC) arising from CL has only been reported, but synchronous melanoma and BCC originating from CL is never reported. We report a very rare case of synchronous melanoma and BCC arising from the lymphedematous upper extremity developed secondary to axillary lymphadenectomy for breast cancer. Read More

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http://dx.doi.org/10.1093/jscr/rjz105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460899PMC
April 2019
1 Read

Gorlin-Goltz syndrome.

Klin Onkol 2019 ;32(2):124-128

Background: Gorlin-Goltz syndrome is an autosomal dominant inherited disorder characterized by a predisposition to various cancers. Clinicopathological findings of syndrome are very diverse and many symptoms begin to manifest in a certain period of life.

Case: The authors describe a case report of a man who, at the age of 34 years, presented to a dermatologist with multiple tumor lesions of the skin. Read More

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http://dx.doi.org/10.14735/amko2019124DOI Listing
January 2019
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Transcriptional Regulation Factors of the Human Mitochondrial Aspartate/Glutamate Carrier Gene, Isoform 2 (): USF1 as Basal Factor and FOXA2 as Activator in Liver Cells.

Int J Mol Sci 2019 Apr 16;20(8). Epub 2019 Apr 16.

Department of Science, University of Basilicata, 85100 Potenza, Italy.

Mitochondrial carriers catalyse the translocation of numerous metabolites across the inner mitochondrial membrane, playing a key role in different cell functions. For this reason, mitochondrial carrier gene expression needs tight regulation. The human gene, encoding for the mitochondrial aspartate/glutamate carrier isoform 2 (AGC2), catalyses the electrogenic exchange of aspartate for glutamate plus a proton, thus taking part in many metabolic processes including the malate-aspartate shuttle. Read More

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http://dx.doi.org/10.3390/ijms20081888DOI Listing
April 2019
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Polymeric micelle nanocarriers for targeted epidermal delivery of the hedgehog pathway inhibitor vismodegib: formulation development and cutaneous biodistribution in human skin.

Expert Opin Drug Deliv 2019 Apr 17. Epub 2019 Apr 17.

a School of Pharmaceutical Sciences , University of Geneva & University of Lausanne , 1 Rue Michel Servet, 1211 Geneva , Switzerland.

Background: The aim was to investigate cutaneous delivery and biodistribution of the hedgehog pathway inhibitor, vismodegib (VSD), indicated for basal cell carcinoma (BCC), from polymeric micelle formulations under infinite/finite dose conditions.

Methods: VSD-loaded micelles were characterized for drug content, particle size and shape; a micelle gel was characterized for its rheological behavior. Cutaneous deposition and biodistribution of VSD were determined using porcine and human skin in vitro with quantification by UHPLC-MS/MS. Read More

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http://dx.doi.org/10.1080/17425247.2019.1609449DOI Listing
April 2019
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Variance of Basal Cell Carcinoma Subtype Reporting by Practice Setting.

JAMA Dermatol 2019 Apr 17. Epub 2019 Apr 17.

Department of Dermatology, University of Southern California, Los Angeles.

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http://archderm.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamadermatol.2019.0066DOI Listing
April 2019
2 Reads

Diagnostic Significance of HRAS Mutations in Epithelial-Myoepithelial Carcinomas Exhibiting a Broad Histopathologic Spectrum.

Am J Surg Pathol 2019 Apr 15. Epub 2019 Apr 15.

Departments of.

Epithelial-myoepithelial carcinoma (EMC) is a rare salivary gland tumor that is histologically characterized by biphasic tubular structures composed of inner ductal and outer clear myoepithelial cells. Because of its histologic variety, it is sometimes challenging to make an accurate diagnosis, and useful ancillary tests are essential for this purpose. We investigated 87 cases of EMC arising in the major and minor salivary glands and seromucinous glands in the nasal cavity or bronchus to describe the histologic features and mutation status of selected key oncogenes. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001258DOI Listing
April 2019
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Basal Cell Carcinoma on a Nevus Sebaceous of Jadassohn: A Case Report.

J Clin Aesthet Dermatol 2019 Mar 1;12(3):40-43. Epub 2019 Mar 1.

Drs. Paninson, Trope, and Ramos-e-Silva are with the Sector of Dermatology, Postgraduation Course in Dermatology at the University Hospital and School of Medicine, Federal University of Rio de Janeiro in Rio de Janeiro, Brazil.

The nevus sebaceous of Jadassohn, usually present at birth, is a hamartoma composed predominantly of sebaceous glands, which can progress to benign and malignant tumors. Malignant neoplasms on the nevus sebaceous occur in about 2.5 percent of cases, with basal cell carcinoma accounting for 1. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440703PMC
March 2019
3 Reads

Depth of Invasion of Aggressive and Nonaggressive Basal Cell Carcinoma.

J Clin Aesthet Dermatol 2019 Mar 1;12(3):12-14. Epub 2019 Mar 1.

Drs. Wetzel and Haeberle and Mr. Brown are with the Division of Dermatology, Department of Medicine, University of Louisville School of Medicine in Louisville, Kentucky.

Dermal invasion is characteristic of more aggressive basal cell carcinoma (BCC) tumors. However, reporting the depth of invasion of BCC is not currently a standard or recommended practice. The purpose of this study was to document the depth of invasion of BCC. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440705PMC
March 2019
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A Retrospective Study of the Diagnostic Accuracy of In Vivo Reflectance Confocal Microscopy for Basal Cell Carcinoma Diagnosis and Subtyping.

J Clin Med 2019 Apr 3;8(4). Epub 2019 Apr 3.

Department of Dermatology, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Current national and European guidelines recommend distinct management approaches for basal cell carcinoma (BCC) based on tumor location, size, and histopathological subtype. In vivo reflectance confocal microscopy (RCM) is a non-invasive skin imaging technique which may change the diagnostic pathway for BCC patients. This study aimed to determine the sensitivity and specificity of RCM for BCC diagnosis, assess the predictive values of several confocal criteria in correctly classifying BCC subtypes, and evaluate the intraobserver reliability of RCM diagnosis for BCC. Read More

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http://dx.doi.org/10.3390/jcm8040449DOI Listing
April 2019
1 Read

Polyacetylenes from the Roots of King.

Molecules 2019 Apr 2;24(7). Epub 2019 Apr 2.

Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.

A phytochemical investigation of the roots of led to the isolation of seven polyacetylenes, including five new compounds (-) and two known ones (-). Their structures were elucidated by extensive spectroscopic analysis and detailed comparison with reported data. All the isolates were tested for their cytotoxicity against the human hepatocellular carcinoma cell line BEL-7402, human myeloid leukemia cell line K562, and human gastric carcinoma cell line SGC-7901. Read More

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https://www.mdpi.com/1420-3049/24/7/1291
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http://dx.doi.org/10.3390/molecules24071291DOI Listing
April 2019
2 Reads

TUMOR BUDDING: PROGNOSTIC VALUE IN MUSCLE-INVASIVE BLADDER CANCER.

Urology 2019 Apr 12. Epub 2019 Apr 12.

Department of Pathology, Hospital University La Fe, Valencia, Spain. Electronic address:

Objetives: To assess if 'tumour budding' (TB) behaves as a poor prognostic factor in muscle-invasive bladder carcinoma (MIBC). TB is the presence of tumour cells isolated or in small groups of fewer than five cells located at the tumour invasion front.

Material And Methods: Retrospective study of 106 patients with MIBC who underwent radical cystectomy. Read More

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http://dx.doi.org/10.1016/j.urology.2019.04.006DOI Listing
April 2019
3 Reads

Inhibiting Hedgehog: An Update on Pharmacological Compounds and Targeting Strategies.

J Med Chem 2019 Apr 24. Epub 2019 Apr 24.

Center for Tumor and Immune Biology (ZTI) , Philipps University Marburg , Hans-Meerwein-Straße 3 , 35043 Marburg , Germany.

Important steps in embryonic development are governed by the Hedgehog (Hh) signaling pathway, an evolutionary conserved signal transduction cascade. However, Hh activity not only is crucial during embryo formation but also is involved in adult tissue repair and in several malignancies. Particularly due to its link to cancer, small molecule Hh pathway inhibitors have been developed and the first compounds have been approved for use in Hh-driven basal cell carcinoma. Read More

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http://dx.doi.org/10.1021/acs.jmedchem.9b00188DOI Listing
April 2019
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The PD-1/PD-L1 Axis in HER2+ Ductal Carcinoma In Situ (DCIS) of the Breast.

Am J Clin Pathol 2019 Apr 15. Epub 2019 Apr 15.

Breast Pathology Section, Department of Pathology, Northwestern University Feinberg School of Medicine, Robert H. Lurie Comprehensive Cancer Center, Chicago, IL.

Objectives: The aims were to evaluate the programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) axis in ductal carcinoma in situ (DCIS) of the breast.

Methods: We reviewed 85 pure DCIS cases treated with surgical excision at our institution, including 51 luminal A (estrogen receptor [ER] positive/human epidermal growth factor 2 [HER2] negative), 15 luminal B (ER+/HER2+), 13 HER2 (ER-/HER2+), and six basal-like (ER-/HER2-/CK5/6+). The extent and intensity of PD-1 and PD-L1 immunohistochemical staining in the tumor-infiltrating lymphocytes (TILs) and in the tumor cells were recorded. Read More

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http://dx.doi.org/10.1093/ajcp/aqz020DOI Listing
April 2019
1 Read

Evaluating the trend of cutaneous malignant tumors in Ilam from 2002 to 2011.

J Family Med Prim Care 2019 Feb;8(2):717-721

Department of Cardiology, Ilam University of Medical Sciences, Ilam, Iran.

Introduction: Skin cancer, the melanoma type of which causes high mortality, is the most common malignancy in Iran and all over the world. UV is the most important cause of the incidence of this disease. This study evaluates the frequency of different types of cancer and their trajectory in Ilam province from 2012 to 2011. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_178_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436317PMC
February 2019
3 Reads

A Collision Tumor: Reflectance Confocal Microscopy Features and Correlation between Dermoscopy and Histopathology.

Indian J Dermatol 2019 Mar-Apr;64(2):155-157

Department of Pathology, Istanbul Training and Research Hospital, Istanbul, Turkey.

Coexistence of two types of malignant neoplasms, called 'a collision tumor,' is relatively uncommon. Basal cell carcinomas (BCCs) are known to coexist with other cutaneous lesions, but the collision of BCC with malignant melanoma is rare. We report a rare case of BCC with underlying lentigo maligna melanoma, focusing on dermoscopic and reflectance confocal microscopic (RCM) findings and their correlation with histopathology. Read More

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http://www.e-ijd.org/text.asp?2019/64/2/155/254153
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http://dx.doi.org/10.4103/ijd.IJD_278_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440176PMC
April 2019
2 Reads

[Application of modified keystone flap in repairing of skin and soft tissue defect around joint].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2019 Apr;33(4):471-474

Department of Plastic Surgery, Changhai Hospital, Naval Medical University, Shanghai, 200433,

Objective: To explore the effectiveness of keystone flap in repairing skin and soft tissue defects around joint.

Methods: Between March 2013 and December 2017, 10 patients of skin and soft tissue defects around the joint were repaired with keystone flaps. There were 6 males and 4 females. Read More

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http://dx.doi.org/10.7507/1002-1892.201812004DOI Listing
April 2019
1 Read

A diagnostic challenge: inflamed and pigmented seborrheic keratosis. Clinical, dermoscopic, and histopathological correlation.

Dermatol Online J 2019 Mar 15;25(3). Epub 2019 Mar 15.

Baskent University Istanbul Hospital Dermatology Clinic, Istanbul.

Pigmented and irritated types of seborrheic keratosis (SK) can be confused with melanoma, basal cell carcinoma, or pigmented actinic keratosis. Dermoscopic examination may give many clues for the diagnosis of SK, but in equivocal cases the accurate diagnosis can only be made by microscopic features. Herein, we report a striking, isolated pigmented and inflamed SK, located on the waist in an elderly man. Read More

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March 2019
3 Reads

Complete healing of basal cell carcinoma under bendamustine and brentuximab vedotin therapy in a patient with cutaneous lymphoma.

Dermatol Ther 2019 Apr 12:e12934. Epub 2019 Apr 12.

Department of Pathology, Istanbul Faculty of Medicine, Istanbul University.

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http://dx.doi.org/10.1111/dth.12934DOI Listing
April 2019
1 Read

National incidence of eyelid cancer in Ireland (2005-2015).

Eye (Lond) 2019 Apr 11. Epub 2019 Apr 11.

Sligo University Hospital, Sligo, Ireland.

Aims: We report on the incidence of cutaneous eyelid tumours in Ireland over the 11-year-period from 2005 to 2015, we identify associations between demographic factors and cutaneous eyelid tumour risk.

Methods: Skin cancers, including basal cell carcinoma (BCC), squamous cell carcinoma (SCC), melanoma, and other cancers, located on the eyelid or canthus according to ICD-10 coding, as registered by the National Cancer Registry of Ireland (NCRI), were captured from the period 2005 to 2015. Age standardised rates (ASR) were calculated according to the European Standard Population (2013). Read More

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http://www.nature.com/articles/s41433-019-0437-8
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http://dx.doi.org/10.1038/s41433-019-0437-8DOI Listing
April 2019
5 Reads

Superficial radiotherapy for non-melanoma skin cancer of the lip: a 44-year Italian experience.

J Dermatolog Treat 2019 Apr 11:1-17. Epub 2019 Apr 11.

a Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Sezione Fotoradioterapia , UO Dermatologia , Milan , Italy.

Background: Radiotherapy is a valuable therapeutic option for the treatment of non-melanoma skin cancer (NMSC) in the ageing population, in non-surgical candidates, or when the tumour is extensive or localised in a cosmetically-sensitive area such as the lips.

Objective: We report our 44-year experience in treating basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) of the vermilion lip using superficial radiotherapy.

Methods: Forty-seven patients with biopsy-proven BCC or SCC of the lip were retrospectively reviewed. Read More

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http://dx.doi.org/10.1080/09546634.2019.1605137DOI Listing
April 2019
5 Reads

Health-related quality of life associated with immunocryosurgery, a minimally invasive modality, for cervicofacial basal cell carcinoma.

Eur J Dermatol 2019 Apr 10. Epub 2019 Apr 10.

Department of Skin and Venereal Diseases, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece.

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http://dx.doi.org/10.1684/ejd.2019.3521DOI Listing

Somatic mutations in kinetochore gene KNSTRN are associated with basal proliferating actinic keratoses and cutaneous squamous cell carcinoma.

J Eur Acad Dermatol Venereol 2019 Apr 11. Epub 2019 Apr 11.

CentroDerm GmbH, Heinz-Fangman-Straße 57, Wuppertal, Germany.

Background: Mutations in kinetochore gene KNSTRN accelerate the development of cutaneous squamous cell carcinoma (SCC) and may correlate with different histological classifications of actinic keratosis (AKs).

Objective: To determine KNSTRN gene mutation frequency in healthy skin (HS), actinically damaged skin (ADS), in AKs with different histomorphological gradings, and invasive SCCs.

Methods: All samples were histologically evaluated. Read More

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http://dx.doi.org/10.1111/jdv.15615DOI Listing
April 2019
2 Reads

Giant basal cell carcinoma: clinical-histological characteristics of 115 cases.

Int J Dermatol 2019 Apr 10. Epub 2019 Apr 10.

Medical Research Division, UMAE Hospital de Pediatria CMNO, IMSS, Guadalajara, Jalisco, Mexico.

Introduction: Giant basal cell carcinoma (GBCC) is a tumor ≥5 cm in size, with aggressive biological behavior, that represents 1% of basal cell carcinomas (BCC), and studies regarding it are scarce. Our objective was to investigate the clinical-histopathological characteristics of GBCC and the risk factors associated with its development.

Methods: A retrospective study over 8 years included patients with the clinical and histopathological diagnosis of GBCC. Read More

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http://dx.doi.org/10.1111/ijd.14455DOI Listing
April 2019
4 Reads

Upregulation of SNAI2 and SOX9 mRNA versus downregulation of eight other EMT/stemness related genes in Basal Cell Carcinoma.

Br J Dermatol 2019 Apr 10. Epub 2019 Apr 10.

Medical Genetics Department, School of Medicine, Tehran University of Medical Sciences, P.O. Box 14155-6447, Tehran, 14176-13151, Iran.

Basal Cell Carcinoma (BCC) is the most common malignancy among fair-skinned people. In contrast to other types of cancer, BCC has the lowest rate of metastasis and mortality. Although several molecular signaling pathways have been documented to play a role in BCC formation, the molecular mechanism to explain why BCC is distinctively rarely metastatic has not been elucidated yet. Read More

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http://dx.doi.org/10.1111/bjd.17995DOI Listing
April 2019
1 Read

Multiple adenoid basal cell carcinoma: An uncommon presentation.

Indian J Dermatol Venereol Leprol 2019 Apr 11. Epub 2019 Apr 11.

Department of Pathology, Cancer Institute, Adyar (W.I.A.), Chennai, Tamil Nadu, India.

Basal cell carcinoma (BCC) is the most common malignant skin tumor which occurs more frequently over the sun exposed parts of body. Its adenoid variant is a rare histological subtype. We report a case of multiple adenoid basal cell carcinomas at unusual sites in a middle-aged male patient. Read More

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http://www.ijdvl.com/preprintarticle.asp?id=255791;type=0
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http://dx.doi.org/10.4103/ijdvl.IJDVL_803_16DOI Listing
April 2019
3 Reads

[Clinicopathological analysis of 187 cases of external nose skin tumors].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Apr;33(4):354-356

Zunyi Medical University, Zunyi, 563000, China.

To explore the pathological types, distribution and characteristics of external nose skin tumors, in order to improve the diagnosis and treatment of such diseases, and provide reference for the clinical diagnosis and treatment of external nose skin tumors. The gender, age of onset, lesion location, lesion size, pathological type, course of disease and related risk factors of all 187 cases with external nose skin tumors in our hospital from January 2008 to December 2017 were analyzed retrospectively. The sex ratio of patients with external nasal skin benign tumors was 1. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2019.04.016DOI Listing

Basal cell carcinomas treated with 0.5% 5-fluorouracil and 10% salicylic acid topical solution.

Dermatol Ther 2019 Apr 9:e12908. Epub 2019 Apr 9.

Dermatologic Unit, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.

Basal cell carcinomas (BCCs) are the most common nonmelanoma skin cancers. Dermoscopy is an indispensable tool to differentiate superficial BCC from other subtypes and between pigmented and not pigmented ones. Although surgery is considered the gold-standard therapy, new current pharmacological options are available and focus on tumor eradication, increasing cosmetic results and functionality. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/dth.12908
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http://dx.doi.org/10.1111/dth.12908DOI Listing
April 2019
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An enigma of Gorlin-Goltz syndrome: Two cases reported in mother and daughter.

J Oral Maxillofac Pathol 2019 Feb;23(Suppl 1):115-121

Department of Oral and Maxillofacial Surgery, Haldia Institute of Dental Sciences and Research, West Bengal University of Health Sciences, Haldia, West Bengal, India.

Gorlin-Goltz syndrome (GGS) also known as the nevoid basal cell carcinoma syndrome or the nevus-Bifid rib syndrome is an inherited autosomal dominant syndrome. It is caused by genetic alteration produced by a mutation in the "patched" tumor suppressor gene. This rare syndrome is characterized by basal cell carcinoma of skin, multiple odontogenic keratocyst and bifid ribs along with other features such as hypertelorism, sex organ abnormalities, palmar and/or plantar pits and calcification of falx cerebri. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_160_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421933PMC
February 2019
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Ameloblastic carcinoma ex ameloblastoma of the maxilla.

J Oral Maxillofac Pathol 2019 Feb;23(Suppl 1):58-62

Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Mahidol University, Bangkok, Thailand.

Ameloblastic carcinoma (AC) is a rare malignant odontogenic tumor. Approximately 138 cases were reported. The majority of these cases occurred in the mandible. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_116_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421907PMC
February 2019
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Quality of life measurement in skin cancer patients: literature review and position paper of the European Academy of Dermatology and Venereology Task Forces on Quality of Life and Patient Oriented Outcomes, Melanoma and Non-Melanoma Skin Cancer.

J Eur Acad Dermatol Venereol 2019 May 8;33(5):816-827. Epub 2019 Apr 8.

Department of Dermatology and Wound Healing, Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.

The European Academy of Dermatology and Venereology (EADV) Task Forces (TFs) on Quality of Life (QoL) and Patient Oriented Outcomes, Melanoma and Non-Melanoma Skin Cancer (NMSC) present a review of the literature and position statement on health-related (HR) QoL assessment in skin cancer patients. A literature search was carried out to identify publications since 1980 that included information about the impact of SC on QoL. Generic, dermatology-specific, cancer-specific, SC-specific, facial SC-specific, NMSC-specific, basal cell carcinoma-specific and melanoma-specific QoL questionnaires have been used to assess HRQoL in SC patients. Read More

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http://dx.doi.org/10.1111/jdv.15487DOI Listing
May 2019
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Breast cancer quantitative proteome and proteogenomic landscape.

Nat Commun 2019 04 8;10(1):1600. Epub 2019 Apr 8.

Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, 171 21, Solna, Sweden.

In the preceding decades, molecular characterization has revolutionized breast cancer (BC) research and therapeutic approaches. Presented herein, an unbiased analysis of breast tumor proteomes, inclusive of 9995 proteins quantified across all tumors, for the first time recapitulates BC subtypes. Additionally, poor-prognosis basal-like and luminal B tumors are further subdivided by immune component infiltration, suggesting the current classification is incomplete. Read More

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http://dx.doi.org/10.1038/s41467-019-09018-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453966PMC
April 2019
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Let-7b-5p inhibits proliferation and motility in squamous cell carcinoma cells through negative modulation of KIAA1377.

Cell Biol Int 2019 Apr 8. Epub 2019 Apr 8.

State Key Laboratory of Pathogenesis, Prevention, Treatment of Central Asian High Incidence Diseases, Xinjiang Uygur Autonomous Region, Urumqi, PR China.

KIAA1377 has been found to be linked with lymph node metastasis in esophageal squamous cell carcinoma in our previous study; however, the regulation of KIAA1377 remains far from understood. Herein, to understand the regulation of KIAA1377 from the angle of miRNA-mRNA modulation in the setting of squamous cell carcinoma (SCC) cells, basal level of KIAA1377 was determined by quantitative real-time PCR (qRT-PCR) and western-blot in KYSE-150 and HeLa cells; Biological roles of KIAA1377 contributed in the proliferation, migration and invasion were evaluated using MTT, wound-healing and Transwell assays, respectively after KIAA1377 was knocked out mediated by CRISPR-Cas9 system. Bioinformatic prediction revealed that let-7b-5p was a putative miRNA regulating KIAA1377, which was ensuingly validated by luciferase reporter assay; after which, variation of KIAA1377 expression was further verified by qRT-PCR and western-blot. Read More

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http://dx.doi.org/10.1002/cbin.11136DOI Listing

Reflectance Confocal Microscopy made easy: the four must-know key features for the diagnosis of melanoma and non-melanoma skin cancers.

J Am Acad Dermatol 2019 Apr 4. Epub 2019 Apr 4.

Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy; Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Centro Oncologico ad Alta Tecnologia Diagnostica-Dermatologia, Reggio Emilia, Italy.

Background: Reflectance confocal microscopy (RCM)-based skin cancer diagnosis requires proficiency.

Aims: To identify a shortlist of key RCM features of skin cancers and test their diagnostic utility.

Methods: We identified key RCM features through consensus among six experts using a modified-Delphi method. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.03.085DOI Listing

Treatment of the facial basal cell carcinoma with the use of photodynamic therapy: A case report.

Dent Med Probl 2019 Jan-Mar;56(1):105-110

Department of Oral Surgery, Faculty of Dentistry, Wrocław Medical University, Poland.

Basal cell carcinoma (BCC) is the most common skin cancer. It accounts for approx. 80% of human skin cancers and belongs to the group of non-melanoma skin cancers (NMSC). Read More

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http://dx.doi.org/10.17219/dmp/100507DOI Listing
April 2019
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Incidence of complications in dermatological surgery of melanoma and non-melanoma skin cancer in patients with multiple comorbidity and/or antiplatelet-anticoagulants. Five year experience in our Hospital.

Cir Cir 2019 ;86(1):15-23

Dermatology Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Mexico City. Mexico.

Introduction: Surgery is performed more frequently now at days, due to the increasing incidence of melanoma and no-melanoma skin cancer. There are different opinions among dermatologic surgeons between to continue or discontinue antithrombotic therapy prior to the procedure, which increases the risk of thromboembolic events. Prophylaxis with oral antibiotics in the postsurgical period is controversial. Read More

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http://dx.doi.org/10.24875/CIRUE.M18000003DOI Listing
January 2019
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