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    1 OF 555

    Conventional Versus Giant Basal Cell Carcinoma, a Review of 57 Cases: Histologic Differences Contributing to Excessive Growth.
    Indian J Dermatol 2018 Mar-Apr;63(2):147-154
    Department of Dermatology, University of Alabama, Birmingham, AL, USA.
    Background: Giant basal cell carcinoma (GBCC) is defined as a basal cell carcinoma (BCC) exceeding 5 cm in size. While these tumors impart significant morbidity due to local tissue destruction and have a higher rate of metastatic disease than their conventional (smaller) counterparts, reasons for their large size remain unclear. While theories relating to neglect or faster growth rate are often invoked; to date, there has not been a comprehensive evaluation of the histologic features of these large tumors that may contribute to their size. Read More

    [Retrospective analysis of 896 cases of parotid gland tumor].
    Shanghai Kou Qiang Yi Xue 2017 Dec;26(6):605-609
    Shengjing Hospital of China Medical University. Shenyang 110004, Liaoning Province, China.
    Purpose: To review the clinical data of patients undergoing operation, in order to summarize the incidence, proportion, clinical examination and diagnostic methods of parotid tumors.

    Methods: Eight hundred and ninty-six cases of parotid gland tumors were collected from 2008 January to 2015 July from department of oral and maxillofacial surgery in Shengjing Hospital of China Medical University. A retrospective study of the clinical data was carried out, including age, gender, tumor location, diagnostic methods and pathological results. Read More

    [Cytologic diagnosis of adenoid cystic carcinoma of salivary glands and distinction from basal cell adenoma].
    Zhonghua Bing Li Xue Za Zhi 2018 Apr;47(4):279-283
    Department of Pathology, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Head and Neck Molecular Diagnostic Pathology of Beijing, Beijing 100730, China.
    To describe the cytologic features of adenoid cystic carcinoma (ADCC) of salivary glands, and to identify distinguishing cytologic features of ADCC and basal cell adenoma (BCA). A retrospective review of cytology smears of 30 cases of ADCC and 12 cases of BCA of salivary glands were performed. All cases were collected from Beijing Tongren Hospital, Capital Medical University from January 2010 to January 2017. Read More

    Oral Capecitabine Achieves Response in Metastatic Eccrine Carcinoma.
    Case Rep Oncol Med 2018 1;2018:7127048. Epub 2018 Mar 1.
    Early Phase Clinical Trial Program, The University of Arizona Cancer Center, 1515 N. Campbell Ave., Tucson, AZ 85724, USA.
    The low prevalence rate and limited literature on eccrine carcinoma (EC) pose a challenge to properly diagnosing and treating this rare malignancy. EC lesions tend to present similarly to other cutaneous neoplasms and dermatitis-like conditions. Efficacious treatment guidelines have not been established for patients diagnosed with EC, and few treatment regimens have demonstrated clinical benefit. Read More

    Upfront Radiotherapy with Concurrent and Adjuvant Vismodegib Is Effective and Well-Tolerated in a Patient with Advanced, Multifocal Basal Cell Carcinoma.
    Case Rep Dermatol Med 2018 21;2018:2354146. Epub 2018 Feb 21.
    Upstate University Hospital, 750 E. Adams Street, Syracuse, NY 13210, USA.
    We present a case report of a male with multifocal and extensive basal cell carcinoma. Due to extremely large size and deep tumor infiltration, he was not a surgical candidate. Combined modality treatment of fractionated radiation with concurrent vismodegib was chosen. Read More

    Incidence of complications in dermatological surgery of melanoma and non-melanoma skin cancer in patients with multiple comorbidity and/or antiplatelet-anticoagulants. Five year experience in our Hospital.
    Cir Cir 2018 ;86(1):20-28
    Departamento de Dermatología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México.
    Introduction: Surgery is performed more frequently now at days, due to the increasing incidence of melanoma and no-melanoma skin cancer. There are different opinions among dermatologic surgeons between to continue or discontinue antithrombotic therapy prior to the procedure, which increases the risk of thromboembolic events. Prophylaxis with oral antibiotics in the postsurgical period is controversial. Read More

    Illuminating Alternative Strategies to Treat Targeted Chemotherapy-Resistant Sporadic Basal Cell Carcinoma.
    J Invest Dermatol 2018 May;138(5):1017-1019
    Department of Developmental and Cell Biology, University of California, Irvine, California, USA; Department of Dermatology, University of California, Irvine, California, USA; Chao Family Comprehensive Cancer Center, University of California, Irvine, California, USA. Electronic address:
    Sporadic and basal cell nevus syndrome basal cell carcinomas show differential response rates to Smoothened inhibitors. Chiang et al. demonstrate notable decreases in UV-induced mutagenesis, total mutation load, genomic instability, and drug-resistant mutations among basal cell nevus syndrome basal cell carcinomas using whole exome sequencing, which may explain the differences in drug response rates. Read More

    Risk of sun-induced skin cancers in patients with alopecia areata, alopecia totalis and alopecia universalis.
    J Eur Acad Dermatol Venereol 2018 Apr 21. Epub 2018 Apr 21.
    Department of Dermatology, Cleveland Clinic Foundation, Cleveland, OH.
    Alopecia areata (AA) is an autoimmune non-scarring hair loss characterized by round patches on the scalp and body. It can progress to alopecia totalis (AT) where there is total loss of scalp hair and alopecia universalis (AU) in where hair loss encompasses the entire body. The pathophysiologic mechanism is unclear, but is thought to be due to peribulbar T-cell inflammation which results in premature induction of anagen follicles to catagen and telogen, without causing destruction of the hair follicle. Read More

    Ectopic hidradenoma papilliferum of eyelid: A rare entity with diagnostic challenge.
    Indian J Pathol Microbiol 2018 Apr-Jun;61(2):287-289
    Department of Pathology, Era's Lucknow Medical College and Hospital, Lucknow, Uttar Pradesh, India.
    Hidradenoma papilliferum is a rare cutaneous adnexal tumour of middle aged females arising mainly in the apocrine sweat glands of perianal and genital region. Ectopic forms of this entity have been described with majority of them occurring on the head and neck region. We report a case of 16 years young male who presented with two small, well circumscribed, greyish-brown, firm, nodules on his left upper and lower eyelid. Read More

    Isolation of Normal Fibroblasts and Their Cancer-Associated Counterparts (CAFs) for Biomedical Research.
    Methods Mol Biol 2018 Apr 20. Epub 2018 Apr 20.
    First Faculty of Medicine, Institute of Anatomy and BIOCEV, Charles University, Prague, Czech Republic.
    Cancer-associated fibroblasts (CAFs) represent a crucial component of cancer microenvironment. CAFs significantly influence biological properties of various types of cancer in terms of local aggressiveness, recurrence, and metastatic behaviour. This chapter summarizes a simple protocol for isolation of normal fibroblasts and their cancer-associated counterparts from normal human skin and mucosa, respectively, as well as from samples of human tumours such as basal/squamous carcinoma, melanoma, and breast cancer, and employment of this procedure for other types of cancer is possible. Read More

    Identification of Human Cutaneous Basal Cell Carcinoma Cancer Stem Cells.
    Methods Mol Biol 2018 Apr 20. Epub 2018 Apr 20.
    European Cancer Stem Cell Research Institute, Cardiff University, Cardiff, UK.
    The cancer stem cell model states that a subset of tumor cells, called "cancer stem cells," can initiate and propagate tumor growth through self-renewal, high proliferative capacity, and their ability to recreate tumor heterogeneity. In basal cell carcinoma (BCC), we have shown that tumor cells that express the cell surface protein CD200 fulfill the cancer stem cell hypothesis. CD200+ CD45- BCC cells represent 0. Read More

    Differentiation of seborrheic keratosis from basal cell carcinoma, nevi and melanoma by RGB autofluorescence imaging.
    Biomed Opt Express 2018 Apr 23;9(4):1852-1858. Epub 2018 Mar 23.
    Institute of Atomic Physics and Spectroscopy, University of Latvia, Raina Blvd. 19, Riga LV-1586, Latvia.
    A clinical trial on the autofluorescence imaging of skin lesions comprising 16 dermatologically confirmed pigmented nevi, 15 seborrheic keratosis, 2 dysplastic nevi, histologically confirmed 17 basal cell carcinomas and 1 melanoma was performed. The autofluorescence spatial properties of the skin lesions were acquired by smartphone RGB camera under 405 nm LED excitation. The diagnostic criterion is based on the calculation of the mean autofluorescence intensity of the examined lesion in the spectral range of 515 nm-700 nm. Read More

    Differential transmission of the molecular signature of RBSP3, LIMD1 and CDC25A in basal/ parabasal versus spinous of normal epithelium during head and neck tumorigenesis: A mechanistic study.
    PLoS One 2018 19;13(4):e0195937. Epub 2018 Apr 19.
    Department of Oncogene Regulation, Chittaranjan National Cancer Institute, Kolkata, India.
    Head and neck squamous cell carcinoma (HNSCC) is a global disease and mortality burden, necessitating the elucidation of its molecular progression for effective disease management. The study aims to understand the molecular profile of three candidate cell cycle regulatory genes, RBSP3, LIMD1 and CDC25A in the basal/ parabasal versus spinous layer of normal oral epithelium and during head and neck tumorigenesis. Immunohistochemical expression and promoter methylation was used to determine the molecular signature in normal oral epithelium. Read More

    Characterisation of DOG-1 Expression in Salivary Gland Tumours and Comparison with Myoepithelial Markers.
    Head Neck Pathol 2018 Apr 18. Epub 2018 Apr 18.
    Unit of Oral and Maxillofacial Pathology, School of Clinical Dentistry, 19 Claremont Crescent, Sheffield, S10 2TA, UK.
    DOG1 is an established diagnostic marker for gastrointestinal stromal tumours (GIST), but has been reported in salivary gland tumours (SGT) as an acinar and intercalated duct marker. However, its specificity and distribution is not well established. The aim of this study was to evaluate the diagnostic utility of DOG-1 expression in SGT in addition to comparing it with myoepithelial markers. Read More

    Analysis of histologic follow-up and risk of malignancy for salivary gland neoplasm of uncertain malignant potential proposed by the milan system for reporting salivary gland cytopathology.
    Cancer Cytopathol 2018 Apr 18. Epub 2018 Apr 18.
    Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, Scottsdale, Arizona.
    Background: The Milan System for Reporting Salivary Gland Cytopathology is a tiered classification scheme that includes 6 diagnostic categories. Neoplasm, which is 1 of the 6 proposed categories, consists of benign neoplasm and neoplasm of uncertain malignant potential (NUMP). NUMP is reserved for a salivary gland neoplasm without clear distinction between benign and malignant. Read More

    EZH2 Expression in Naturally Occurring Canine Tumors.
    Comp Med 2018 Apr;68(2):148-155
    University of Ulsan College of Medicine, Asan Institute for Life Sciences, and Department of Pathology, Asan Medical Center, Seoul, Korea., Email:
    Enhancer of zeste homolog 2 (EZH2) shows upregulated expression in tumors and is an important driver of tumor development and progression. However, the mechanism underlying the mediation of tumor aggressiveness by EZH2 remains unclear. We here investigated the levels of EZH2 in various normal and tumorous dog tissues and compared these patterns with those of the corresponding human tissues. Read More

    MEKK2 and MEKK3 suppress Hedgehog pathway-dependent medulloblastoma by inhibiting GLI1 function.
    Oncogene 2018 Apr 17. Epub 2018 Apr 17.
    Life Sciences Institute and Innovation Center for Cell Signaling Network, Zhejiang University, Hangzhou, 310058, China.
    Hedgehog (Hh) pathway plays a pivotal role in diverse aspects of development and postnatal physiology. Perturbation of Hh signaling and activation of GLI1 (glioma-associated oncogene 1), a dedicated transcription factor for Hh pathway, are highly associated with several cancers, such as medulloblastoma and basal cell carcinoma. Dynamic and precise control of GLI1 activity is thus important to ensure proper homeostasis and tumorigenesis. Read More

    Cutaneous Head and Neck Malignancies in the Elderly.
    Clin Geriatr Med 2018 May 17;34(2):245-258. Epub 2018 Feb 17.
    Otolaryngology-Head and Neck Surgery, Head and Neck-Microvascular Surgery, Clinical Affairs, Indiana University School of Medicine, Fesler Hall, 1130 W. Michigan Street, Suite 400, Indianapolis, IN 46202, USA.
    Cutaneous malignancy of the head and neck affects a large proportion of elderly patients. The severity ranges from small, easily treatable lesions to large, invasive, potentially metastatic tumors. Surgical treatment is the primary treatment of most skin cancers; however, geriatric patients are more likely to have multiple comorbidities that increase the risk of surgery. Read More

    MUSE (Microscopy with UV Surface Excitation): a novel approach to real-time inexpensive slide free dermatopathology.
    J Cutan Pathol 2018 Apr 16. Epub 2018 Apr 16.
    Department of Pathology and Laboratory Medicine, University of California, Sacramento, CA, USA.
    Traditional histology relies on processing and physically sectioning either frozen or formalin-fixed, paraffin-embedded (FFPE) tissue into thin slices (typically 4-6 microns) prior to staining and viewing on a standard wide-field microscope. MUSE represents a novel alternative microscopy method that works with ultraviolet (UV) excitation using oblique cis-illumination which can generate high-quality images from the cut surface of fresh or fixed tissue after brief staining, with no requirement for fixation, embedding and histological sectioning of tissue specimens. We examined its potential utility in dermatopathology. Read More

    Familial Syndromes Involving Meningiomas Provide Mechanistic Insight Into Sporadic Disease.
    Neurosurgery 2018 Apr 11. Epub 2018 Apr 11.
    Vivian L. Smith Department of Neurosur-gery, University of Texas Health Science Center at Houston, Texas.
    Currently, there is an incomplete understanding of the molecular pathogenesis of meningiomas, the most common primary brain tumor. Several familial syndromes are characterized by increased meningioma risk, and the genetics of these syndromes provides mechanistic insight into sporadic disease. The best defined of these syndromes is neurofibromatosis type 2, which is caused by a mutation in the NF2 gene and has a meningioma incidence of approximately 50%. Read More

    PGE /EP antagonism enhances tumor chemosensitivity by inducing extracellular vesicle-mediated clearance of cancer stem cells.
    Int J Cancer 2018 Apr 15. Epub 2018 Apr 15.
    Institute of Cellular and System Medicine, National Health Research Institutes, Miaoli 35053, Taiwan.
    Cells expressing mesenchymal/basal phenotypes in tumors have been associated with stem cell properties. Cancer stem cells (CSCs) are often resistant to conventional chemotherapy. We explored overcoming mesenchymal CSC resistance to chemotherapeutic agents. Read More

    FACE-Q Skin Cancer Module for Measuring Patient-Reported Outcomes Following Facial Skin Cancer Surgery.
    Br J Dermatol 2018 Apr 14. Epub 2018 Apr 14.
    Plastic and Reconstructive Surgery Division, Brigham and Women's Hospital, Boston, MA, USA.
    Background: The patient's perspective of their facial scar after skin cancer surgery influences perception of care and quality of life. Appearance satisfaction after surgery is also an important but often overlooked treatment outcome.

    Objectives: To report the psychometric validation of the FACE-Q Skin Cancer Module consisting of 5 scales measuring appearance satisfaction (Satisfaction with Facial Appearance, Appraisal of Scars), quality of life (Cancer Worry, Appearance-related Psychosocial Distress) and the patient experience (Satisfaction with Information: Appearance). Read More

    Progression of urothelial carcinoma in situ of the urinary bladder: a switch from luminal to basal phenotype and related therapeutic implications.
    Virchows Arch 2018 Apr 13. Epub 2018 Apr 13.
    Institute of Pathology, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen, Germany.
    The stratification of bladder cancer into luminal and basal tumors has recently been introduced as a novel prognostic system in patient cohorts of muscle-invasive bladder cancer or high-grade papillary carcinomas. Using a representative immunohistochemistry panel, we analyzed luminal and basal marker expression in a large case series (n = 156) of urothelial carcinoma in situ (CIS), a precancerous lesion that frequently progresses to muscle-invasive disease. The majority of CIS cases was characterized by a positivity for luminal markers (aberrant cytokeratin (CK) 20 85% (132/156), GATA3 median Remmele score (score of staining intensity (0-3) multiplied with percentage of positive cells (0-4)): 12, estrogen receptor (ER) β Remmele score > 2: 88% (138/156), human epidermal growth factor receptor 2 (Her2) Dako score 3+ 32% (50/156), Her2 Dako score 2+ 33% (51/156)), and marginal expression of basal markers (CK5/6+ 2% (3/156), CK14+ 1% (2/156)). Read More

    Deregulation of LIMD1-VHL-HIF-1α-VEGF pathway is associated with different stages of cervical cancer.
    Biochem J 2018 Apr 13. Epub 2018 Apr 13.
    Department of Oncogene Regulation, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, Kolkata-700026, West Bengal, India, Kolkata, India
    To understand the mechanism of cellular stress in basal-parabasal layers of normal-cervix and during different stages of cervical carcinoma, we analyzed the alterations (expression/methylation/copy-number variation/mutation) of HIF-1α and its associated genes LIMD1, VHL and VEGF in disease free normal-cervix (n=9), adjacent normal-cervix of tumors (n=70), CIN (n=32), CACX (n=174) samples and two CACX cell lines. In basal-parabasal layers of normal-cervix, LIMD1 showed high protein-expression while low protein expression of VHL was concordant with high expression of HIF-1α and VEGF irrespective of HPV16 infection. This was in concordance with the low promoter methylation of LIMD1 and high in VHL in the basal-parabasal layers of normal-cervix. Read More

    In Vitro Anticancer Activity of Staphyloxanthin Pigment Extracted from KX912244, a Gut Microbe of .
    Indian J Microbiol 2018 Jun 16;58(2):146-158. Epub 2018 Mar 16.
    Department of Biotechnology and Microbiology, Karnatak University, Dharwad, 580003 Karnataka India.
    The present study reports the in vitro biological nature of the pigment produced by KX912244, isolated as the gut microflora bacterium of the insect . The purified pigment was characterized as Staphyloxanthin based on bio-physical characterization techniques like Fourier transform infrared spectroscopy, high performance liquid chromatography, Proton nuclear magnetic resonance spectroscopy (H NMR), Liquid chromatography-Mass spectroscopy and Gas chromatography-Mass spectroscopy. The Staphyloxanthin pigment presented considerable biological properties including in vitro antimicrobial activity against pathogens , and ; in vitro antioxidant activity by % DPPH free radical scavenging activity showing IC value of 54. Read More

    Nonvenereal Penile Dermatoses: A Retrospective Study.
    Indian Dermatol Online J 2018 Mar-Apr;9(2):96-100
    University Clinic of Dermatology, Hospital de Santa Maria, Lisbon, Portugal.
    Context: A variety of nonvenereal diseases can affect the penis and diminish quality of life. Many present similar clinical features and a cutaneous biopsy may be necessary to clarify the diagnosis.

    Aims: To characterize nonvenereal penile dermatoses with histological confirmation in a southwestern Europe hospital during a 9-year period. Read More

    An anterolateral thigh chimeric flap for dynamic facial and esthetic reconstruction after oncological surgery in the maxillofacial region: a case report.
    Head Face Med 2018 Apr 11;14(1). Epub 2018 Apr 11.
    Department of Oral and Maxillofacial Surgery, University of Szeged, Kálvária 57, Szeged, H-6725, Hungary.
    Background: The surgical management of malignant tumors in the head and neck region often leads to functional and esthetic defects that impair the quality of life of the patients. Reconstruction can be solved with prostheses in these cases, but various types of microsurgical free flaps can provide a better clinical outcome.

    Case Presentation: In this case report, the tumor and parts of the involved facial muscles and nerve were excised surgically from a 42-year-old patient after a third relapse of basal cell carcinoma in the left midface. Read More

    Clinicopathological significance of cystatin A expression in progression of esophageal squamous cell carcinoma.
    Medicine (Baltimore) 2018 Apr;97(15):e0357
    Department of Gastroenterology, The Research Center for Hepatitis and Immunology, Research Institute, National Center for Global Health and Medicine, Chiba.
    We previously conducted transcriptome analysis of a paired specimen of normal and esophageal squamous cell carcinoma (ESCC) tissues and found that mRNA expression of cystatin A (CSTA), a member of the cystatin superfamily, was perturbed in tumors compared with that in the background mucosa. However, little is known about the significance of CSTA expression in ESCC.The mRNA expression of CSTA was evaluated by qRT-PCR using 28 paired frozen samples of tumor and nontumor mucosae. Read More

    Periungual basal cell carcinoma.
    An Bras Dermatol 2018 Jan-Feb;93(1):114-115
    Dermatology Service at Hospital Naval Marcílio Dias (HNMD) - Rio de Janeiro (RJ), Brazil.
    Periungual basal cell carcinoma is rare and needs to be differentiated from other common diseases that affect this region. Several factors are associated with the development of this tumor, and sun damage seems to play an important role in its pathogenesis. Dermoscopy of clinically indolent lesions on the nail unit can shorten the diagnostic process and avoid destructive treatment and functional damage. Read More

    Pigmented squamous cell carcinoma: case report and importance of differential diagnosis.
    An Bras Dermatol 2018 Jan-Feb;93(1):96-98
    Division of Surgery at Fundação Alfredo da Matta (FUAM) - Manaus (AM), Brazil.
    A few cases of pigmented squamous cell carcinoma affecting the skin and the ocular and oral mucosa of the elderly have been described in the literature. The disease manifests itself as papular and nodular erythematous or pigmented lesions. The main clinical differential diagnoses are pigmented basal cell carcinoma and melanoma. Read More

    Fat intake and risk of skin cancer in US adults.
    Cancer Epidemiol Biomarkers Prev 2018 Apr 10. Epub 2018 Apr 10.
    Department of Dermatology, Brown University
    Background: Fat intake has been associated with certain cancers, including colorectal, breast, and prostate cancers. However, literature on dietary fat and skin cancer has been limited.

    Methods: We examined the association between fat intake and risk of skin cancer including cutaneous malignant melanoma, squamous cell carcinoma (SCC), and basal cell carcinoma (BCC) within two prospective studies; the Nurses' Health Study (NHS) and the Health Professionals Follow-up Study (HPFS). Read More

    Infiltrative basal cell carcinoma mimicking tinea corporis.
    Dermatol Online J 2018 Mar 15;24(3). Epub 2018 Mar 15.
    Department of Dermatology, Baylor College of Medicine, Houston, Texas.
    The diagnosis of infiltrative basal cell carcinoma (BCC) can be delayed owing to its often subtle clinical findings. A 90-year-old woman presented with an asymptomatic annular pink plaque on her left shin that was clinically diagnosed as tinea corporis. After years of not responding to topical anti-fungal therapy, biopsies confirmed a diagnosis of infiltrative BCC. Read More

    Conjunctival Lesions: When Should We Perform Biopsy?
    Nepal J Ophthalmol 2017 Jul;9(18):160-169
    Introduction: The conjunctiva is a thin and flexible mucus membrane that provides a protective barrier for the eye. Very few histopathologic studies have been conducted on biopsies from conjunctival lesions (CL) in central India.

    Objective: To study the spectrum of CL and define those lesions that need attention with regard to need of biopsy in order to prevent grave sequelae and ocular morbidity. Read More

    Accuracy of dermoscopic criteria for the differentiation between superficial basal cell carcinoma and Bowen's disease.
    J Eur Acad Dermatol Venereol 2018 Apr 6. Epub 2018 Apr 6.
    First Department of Dermatology, Aristotle University, Thessaloniki, Greece.
    Background: The dermoscopic features of superficial basal cell carcinoma (sBCC) and Bowen's disease (BD) have been extensively investigated and dermoscopy was shown to significantly improve their recognition. However, incorrectly diagnosed cases still exist, with a considerable number of sBCCs dermoscopically interpreted as BD. Our aim was to investigate the dermoscopic variability of sBCC and BD on different anatomic sites, to identify potent dermoscopic predictors for each diagnosis and to investigate the potential source of the inaccurate clinico-dermoscopic diagnosis of some sBCCs. Read More

    Laser-assisted photodynamic therapy for superficial basal cell carcinoma and Bowen's Disease: a randomised intra-patient comparison between a continuous and a fractional ablative CO laser mode.
    J Eur Acad Dermatol Venereol 2018 Apr 6. Epub 2018 Apr 6.
    Department of Dermatology, Ghent University Hospital, Belgium.
    Background: Laser-assisted photodynamic therapy is being explored as a method to enhance efficacy of photodynamic therapy (PDT).

    Objective: To compare a continuous (CL) and a fractional (FL) ablative CO laser-assisted methyl aminolevulinate PDT in the management of superficial basal cell carcinoma (sBCC) and Bowen's Disease (BD).

    Methods: Thirty treatment areas in fifteen patients with inoperable, histologically verified sBCC or BD, received CL or FL after intra-patient randomisation. Read More

    Basal cell carcinoma: the utility of in vivo and ex vivo confocal microscopy.
    J Eur Acad Dermatol Venereol 2018 Apr 6. Epub 2018 Apr 6.
    Dermatology Unit, University of Modena and Reggio Emilia, Modena, Italy.
    The use of confocal microscopy is possible by using two different modalities: first, at patient's bedside for a rapid in vivo diagnosis of basal cell carcinoma and second, in the operating room directly on freshly excised specimen for a fast ex vivo margin controlled surgery. In the current review we report the main application of confocal microscopy for basal cell carcinoma diagnosis and management in both modalities. This article is protected by copyright. Read More

    EZH2 Expression in Naturally Occurring Canine Tumors.
    Comp Med 2019 Mar;68(2):148-155
    University of Ulsan College of Medicine, Asan Institute for Life Sciences, and Department of Pathology, Asan Medical Center, Seoul, Korea;, Email:
    Enhancer of zeste homolog 2 (EZH2) shows upregulated expression in tumors and is an important driver of tumor development and progression. However, the mechanism underlying the mediation of tumor aggressiveness by EZH2 remains unclear. We here investigated the levels of EZH2 in various normal and tumorous dog tissues and compared these patterns with those of the corresponding human tissues. Read More

    [Predictive diagnosis in breast cancer - Whats new in 2018?]
    Cesk Patol 2018 ;54(1):13-16
    Detection of predictive markers in breast carcinoma has undergone significant changes, the most important ones - at least in the context of Czech Republic - are related to the detection of HER2 - detection of both over-expression of oncoprotein HER-2/neu and amplification of the c-erbB-2 gene, respectively. In the Czech Republic, immunohistochemical testing is performed as a method of first choice, followed, if needed, by in situ hybridization. The update of the guidelines published in 2013 decreased the threshold for positive tumor cells from 30% to 10%, shifted the threshold for gene amplification (HER2/CEP17 ratio) from 2. Read More

    A case illustrating successful eradication of recurrent, aggressive basal cell carcinoma located in a scar with vismodegib.
    Dermatol Online J 2018 Feb 15;24(2). Epub 2018 Feb 15.
    Departments of Dermatology, Oregon Health & Sciences University, Portland, Oregon.
    Vismodegib is a small molecule inhibitor of the Hedgehog signaling pathway that has shown efficacy in the control of locally advanced or metastatic basal cell carcinoma, although proof of its effectiveness in the elimination of aggressive tumors is lacking. We report a case and provide complete histological evidence of a 69-year-old gentleman who presented with a recurrent, infiltrative, and sclerosing (morpheiform) basal cell carcinoma on his left upper lip that was entirely eradicated with a three-month course of vismodegib 150 mg daily. Complete histologic clearance of a tumor in a recurrent, infiltrative, and sclerosing basal cell carcinoma with vismodegib is uncommon. Read More

    Evaluation of p53 and Ki67 Expression Profiles in Basal Cell Carcinomas in a Usual and an Unusual Location.
    Turk Patoloji Derg 2018 Apr 9. Epub 2018 Apr 9.
    Department of Pathology, Ankara Yıldırım Beyazit University, Ankara Ataturk Research and Training Hospital, ANKARA, TURKEY.
    Objective: Owing to their importance in cell proliferation in cutaneous malignancies, we aimed to immunohistochemically compare the expression profiles of p53 and Ki67 in basal cell carcinoma (BCC) cases in both a usual and an unusual locations in this study.

    Material And Method: In this study we included 12 in an unusual location of BCC cases and 21 BCC cases in a usual location. Immunohistochemical expression of p53 and Ki67 antibodies were studied in 33 paraffin-embedded tissue specimens of basal cell carcinoma. Read More

    Utility of Ber-EP4 and MOC-31 in Basaloid Skin Tumor Detection.
    Appl Immunohistochem Mol Morphol 2018 Apr 7. Epub 2018 Apr 7.
    Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB, Canada.
    Ber-EP4 has been the traditional immunostain used for the detection of basaloid skin tumors. Recently, MOC-31 has shown be superior to Ber-EP4 in the detection of basosquamous basal cell carcinoma (BCC) and many centers are now using both Ber-EP4 and MOC-31 antibodies together to detect these lesions. The objective of this study was to compare the utility of using both Ber-EP4 and MOC-31 immunostains in the detection of basaloid skin tumors and to better characterize the previously unknown staining properties of MOC-31 in cutaneous lesions. Read More

    Primary basosquamous carcinoma of the lower eyelid with ocular invasion A case report.
    Ann Ital Chir 2018 Mar 26;7. Epub 2018 Mar 26.
    Introduction: Ocular invasion is extremely rare for a primary eyelid Basosquamous Carcinoma (BSC). It can however occur in neglected cases if the clinical signs are overseen and the BSC is misdiagnosed for a less aggressive skin carcinoma.

    Materials And Methods: A 58-year-old man suffering from an inferior eyelid BSC that had been neglected for 7 years was referred to our clinic. Read More

    [Microcystic adnexal carcinoma: A case report].
    Ann Pathol 2018 Apr 2. Epub 2018 Apr 2.
    Service de dermatologie, CHU de Caen, avenue côte-de-nacre, 14033 Caen, France.
    We report a case of microcystic adnexal carcinoma in a 80-year-old woman. This is a rare malignant adnexal cutaneous tumor with glandular and follicular differentiation, rare, often asymptomatic, with late diagnosis and slow growth, locally aggressive and rarely metastatic. The distinction with other benign and malignant skin tumors is difficult. Read More

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