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    Conservative Treatment of Multiple Keratocystic Odontogenic Tumors in a Young Patient with Nevoid Basal Cell Carcinoma Syndrome by Decompression: A 7-year Follow-up Study.
    J Clin Pediatr Dent 2017 ;41(4):300-304
    Multiple keratocystic odontogenic tumors (KCOT) occurred in a young child is challenging problem in the field of pediatric dentistry, and might have been related to nevoid basal cell carcinoma syndrome (NBCCS). Because of high recurrence rate of KCOTs, complete surgical resection is generally accepted as definitive treatment. However, complete surgical resection could induce negative effect on the development of permanent teeth and growth of jaw. Read More

    Keratin gene mutations influence the keratinocyte response to DNA damage and cytokine induced apoptosis.
    Arch Dermatol Res 2017 Jun 24. Epub 2017 Jun 24.
    Faculty of Medicine, Medical Centre for Molecular Biology, University of Ljubljana, Ljubljana, Slovenia.
    The keratin filament cytoskeleton is vital to the normal function of epithelial cells. It provides structural support and regulates different aspects of cell metabolism. Mutations in keratins 5 and 14 cause a skin fragility disorder, epidermolysis bullosa simplex (EBS). Read More

    Vismodegib for Recurrent Locally Destructive Basal Cell Carcinoma in a Renal Transplant Patient.
    J Eur Acad Dermatol Venereol 2017 Jun 24. Epub 2017 Jun 24.
    Department of Dermatology, Paracelsus Medical University, Salzburg, Austria.
    Solid organ transplant patients are at an increased risk of developing cutaneous malignancies owing to long-lasting immunosuppression. The strongest increase in incidence (35-fold) has been reported for cutaneous squamous cell carcinoma [1]. Basal cell carcinoma (BCC) may occur even more frequently, especially during the first years after transplantation [2]. Read More

    A pathways-based prediction model for classifying breast cancer subtypes.
    Oncotarget 2017 Jun 17. Epub 2017 Jun 17.
    Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Heilongjiang Province, China.
    Breast cancer is highly heterogeneous and is classified into four subtypes characterized by specific biological traits, treatment responses, and clinical prognoses. We performed a systemic analysis of 698 breast cancer patient samples from The Cancer Genome Atlas project database. We identified 136 breast cancer genes differentially expressed among the four subtypes. Read More

    Improved boundary segmentation of skin lesions in high-frequency 3D ultrasound.
    Comput Biol Med 2017 Jun 15;87:302-310. Epub 2017 Jun 15.
    Atys Medical, Soucieu-En-Jarrest, France.
    In this article, we propose a segmentation algorithm for skin lesions in 3D high-frequency ultrasound images. The segmentation is done on melanoma and Basal-cell carcinoma tumors, the most common skin cancer types, and could be used for diagnosis and surgical excision planning in a clinical context. Compared with previously proposed algorithms, which tend to underestimate the size of the lesion, we propose two new boundary terms which provide significant improvements of the accuracy. Read More

    Common malignant cutaneous conditions among albinos in Kenya.
    Med J Islam Repub Iran 2017 11;31. Epub 2017 Jan 11.
    Skin Research Center, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran & Iranian Red Crescent Society, Tehran, Iran.
    Background: Albinos in Africa are at constant risk of developing skin cancer due to the damage caused by ultra-violet exposure. This study identifies the common skin conditions among albinos in Kenya as a country located along the equator. Methods: In this descriptive study on albino patients who were admitted to Mbagathi District Hospital in Nairobi, Kenya the census method was used for sampling and a total of 151 albinos were registered. Read More

    Lichenoid keratosis is frequently misdiagnosed as basal cell carcinoma.
    Clin Exp Dermatol 2017 Jun 21. Epub 2017 Jun 21.
    Department of Dermatology, Sir Charles Gairdner Hospital, Nedlands, Perth, WA, Australia.
    Lichenoid keratosis (LK), also known as benign lichenoid keratosis or lichen planus-like keratosis, is a solitary, pink to red-brown scaly plaque representing a host immunological response to a variety of precursor lesions. LK is often misdiagnosed as a dermatological malignancy owing to its clinical resemblance to basal cell carcinoma (BCC) or Bowen disease. We performed a retrospective analysis of the pathology records of a series of LK lesions with reference to the demographic features and accuracy of clinical diagnosis. Read More

    Multiple papulonodular lesions on central area of the face: what is your diagnosis?
    Dermatol Online J 2017 Jun 15;23(6). Epub 2017 Jun 15.
    Department of Dermatology, Hospital de Santarém EPE, Santarém, Portugal.
    A healthy 31-year-old woman presented with a 20-year history of asymptomatic skin-colored papules and nodules on the central area of the face. Her maternal grandmother, aunts, mother, and sister also had similar lesions. Clinical, histopathological, and genetic features allowed the diagnosis of multiple familial trichoepithelioma. Read More

    PSIP1/p75 promotes tumorigenicity in breast cancer cells by promoting the transcription of cell cycle genes.
    Carcinogenesis 2017 Jun 17. Epub 2017 Jun 17.
    Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, IL 61801.
    Breast cancer (BC) is a highly heterogeneous disease, both at the pathological and molecular level, and several chromatin-associated proteins play crucial roles in breast cancer initiation and progression. Here, we demonstrate the role of PSIP1 (PC4 and SF2 interacting protein)/p75 (LEDGF) in breast cancer progression. PSIP1/p75, previously identified as a chromatin-adaptor protein, is found to be upregulated in basal-like/triple negative breast cancer (TNBC) patient samples and cell lines. Read More

    Human papillomavirus related oropharyngeal cancer.
    Ann Oncol 2017 Jun 15. Epub 2017 Jun 15.
    Department of Medical Oncology, Catalan Institute of Oncology (ICO), IDIBELL. L'Hospitalet de Llobregat, Barcelona, Spain.
    High-risk (HR) human papillomavirus (HPV) is now recognised as the principal cause of the increasing incidence rates of oropharyngeal squamous cell carcinoma (OPSCC) in some parts of the world.The primary risk factor for developing HPV-related OPSCC is oral HPV-infection and the majority of oral HPV-infections are acquired by oral sex. Progression into a OPSCC includes persistent infection with evasion of immune response in the microenvironment, the activation of viral early genes (E6, E7) in basal epithelial cells, the deregulation of cell cycle and the accumulation of chromosomal instability. Read More

    Approach to management of giant basal cell carcinomas.
    Cutis 2017 May;99(5):356-362
    Division of Dermatology, Creighton University School of Medicine, Omaha, Nebraska, USA.
    Basal cell carcinoma (BCC) is a common nonmelanoma skin cancer with increasing incidence in the United States and worldwide. It is strongly linked to UV radiation exposure and typically is slow growing. Malignancy in BCCs is due to local growth and invasion rather than metastasis, and the prognosis is generally favorable. Read More

    Claw foot A case report.
    Ann Ital Chir 2017 Jun 8;6. Epub 2017 Jun 8.
    A cutaneous horn could be defined as a conical projection on the surface of skin made of cornified material and resembling an animal horn. These lesions most commonly affect light-skinned men aged between 50 to 89 years and usually appear in sun exposed areas. Radiation, chronic irritation and even human papilloma virus-2 infection may be precipitating factors. Read More

    Inoperable infiltrative basal cell carcinoma successfully treated with vismodegib.
    Dermatol Ther 2017 Jun 19. Epub 2017 Jun 19.
    Sina Pathobiology Laboratory, Rasht, Iran.
    Basal cell carcinoma (BCC) is the most common skin cancer but usually has a good prognosis. However, there is a subset of BCC cases with a less favorable prognosis. For patients with locally advanced, recurrent or metastatic BCCs who are not suitable for surgery or radiotherapy, small-molecule drug inhibitors of hedgehog pathway are a new therapeutic opportunity. Read More

    Familial seborrhoeic keratosis associated with multiple "pure reticulated acanthomas" and infundibulocystic basal cell carcinomas.
    Br J Dermatol 2017 Jun 18. Epub 2017 Jun 18.
    Department of Pathology, Hospital Clínico Universitario-INCLIVA, University of Valencia, Valencia, Spain.
    Background: A variety of genodermatoses with multiple cutaneous tumors with germline genetic alterations such as Gorlin syndrome with PTCH1 gene mutations have been described. Other cutaneous syndromes have been associated with somatic gene mutations, such as FGFR3 in familial seborrhoeic keratosis.

    Objective: We describe the clinical, dermoscopic, and histopathological features of multiple cutaneous lesions, mostly infundibulocystic basal cell carcinomas and pure reticulated acanthomas, present in a family affected by familial seborrhoeic keratosis. Read More

    From basal cell morphogenesis to the alopecia induced by hedgehog inhibitors: connecting the dots.
    Br J Dermatol 2017 Jun 18. Epub 2017 Jun 18.
    Oncology Unit, 1st Department of Dermatology, University of Athens, Andreas Syggros Hospital, Athens, Greece.
    The deciphering of the hedgehog (Hh) signaling pathway implicated in the tumorigenesis of basal cell carcinoma (BCC), led to the development of targeted drug therapies, e.g. the hedgehog pathway inhibitors (HPI), vismodegib and sonidegib. Read More

    Reflectance confocal microscopic presentation of basosquamous carcinoma.
    J Eur Acad Dermatol Venereol 2017 Jun 16. Epub 2017 Jun 16.
    Department of Dermatology, Medical University of Graz, Graz, Austria.
    Basosquamous carcinoma (BSC) is considered a variant of basal cell carcinoma (BCC) associated with squamous differentiation.(1) It may display local aggressive behavior, and increased potential for recurrence and metastases.(2) Therefore, early and appropriate treatment will have prognostic repercussion. Read More

    Cancer Surveillance in Gorlin Syndrome and Rhabdoid Tumor Predisposition Syndrome.
    Clin Cancer Res 2017 Jun;23(12):e62-e67
    Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Harvard Medical School, Boston, Massachusetts.
    Gorlin syndrome and rhabdoid tumor predisposition syndrome (RTPS) are autosomal dominant syndromes associated with an increased risk of childhood-onset brain tumors. Individuals with Gorlin syndrome can manifest a wide range of phenotypic abnormalities, with about 5% of family members developing medulloblastoma, usually occurring in the first 3 years of life. Gorlin syndrome is associated with germline mutations in components of the Sonic Hedgehog pathway, including Patched1 (PTCH1) and Suppressor of fused (SUFU)SUFU mutation carriers appear to have an especially high risk of early-onset medulloblastoma. Read More

    Rapid ex vivo examination of Mohs specimens using optical coherence tomography.
    Photodiagnosis Photodyn Ther 2017 Jun 12. Epub 2017 Jun 12.
    Department of Dermatology, University College Hospitals, London, UK.
    Background: Mohs micrographic surgery (MMS) is an effective treatment for certain non-melanoma skin cancers. Optical coherence tomography (OCT) is a biomedical imaging modality that permits high-resolution imaging of the epidermis and dermis with the potential to detect both healthy tissue and tumour. OCT may also provide a means of detecting and differentiating between the various histological subtypes of basal cell carcinomas (BCC) in vivo. Read More

    Outcomes of radiation therapy for advanced T3/T4 non-melanoma cutaneous squamous cell and basal cell carcinoma.
    Br J Dermatol 2017 Jun 15. Epub 2017 Jun 15.
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
    Non-melanoma cutaneous squamous and basal cell carcinoma (NMSC) is common, and most patients present with early stage (T1/T2) NMSC, which has an excellent prognosis. However, a minority of NMSC patients present with an advanced stage (T3/T4) primary tumor, which may be surgically unresectable but potentially curable with radiation therapy (RT). Because advanced NMSC is rare, studies(1-5) examining the outcomes of RT for patients with T3/T4 tumors are limited. Read More

    Regulation of type 1 iodothyronine deiodinase by LXRα.
    PLoS One 2017 15;12(6):e0179213. Epub 2017 Jun 15.
    Department of Diabetes, Endocrinology and Nutrition, Kyoto University Graduate School of Medicine, Kyoto, Japan.
    The iodothyronine deiodinases are selenoenzymes that regulate the activity of thyroid hormone via specific inner- or outer-ring deiodination. In humans, type 1 deiodinase (D1) is highly expressed in the liver, but the mechanism by which its gene expression is regulated remains to be elucidated. Liver X receptor α (LXRα), a transcription factor of the nuclear receptor superfamily, is highly expressed in the liver, where it functions as a sensor for excess intracellular oxysterols. Read More

    Risk of second malignancies in solid organ transplant recipients who develop keratinocyte cancers.
    Cancer Res 2017 Jun 14. Epub 2017 Jun 14.
    Division of Cancer Epidemiology and Genetics, National Cancer Institute
    Solid organ transplant recipients have increased risk for developing keratinocyte cancers (KC), including cutaneous squamous cell carcinoma (SCC) and basal cell carcinoma (BCC), in part as a result of immunosuppressive medications administered to prevent graft rejection. In the general population, KC are associated with increased risks of subsequent malignancy, however, the risk in organ transplant populations has not been evaluated. We addressed this question by linking the U. Read More

    Spectrum of Changes in Anogenital Mammary-like Glands in Primary Extramammary (Anogenital) Paget Disease and Their Possible Role in the Pathogenesis of the Disease.
    Am J Surg Pathol 2017 Jun 13. Epub 2017 Jun 13.
    *Department of Pathology, Clinical Research and Practical Center for Specialized Oncological Care †Department of Pathology, Medical Faculty, Saint-Petersburg State University ‡Department of Pathology, Saint-Petersburg Medico-Social Institute ∥∥Department of Dermatology, Medical Military Academy, Saint Petersburg, Russia §PathWest Laboratory Medicine WA, QEII Medical Centre ∥School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands ¶PathWest Laboratory Medicine WA, King Edward Memorial Hospital, Perth, WA, Australia #Sikl's Department of Pathology, Medical Faculty in Pilsen, Charles University in Prague **Bioptical Laboratory §§Department of Obstetrics and Gynecology, Charles University Medical Faculty Hospital, Pilsen, Czech Republic ††Miraca Life Science, Irving, TX ‡‡Department of Pathology, Division of Dermatopathology, Medical College of Wisconsin, Milwaukee, WI ¶¶Dermatopathology Unit, Department of Dermatology, Zurich University Hospital, Zurich, Switzerland.
    To determine whether a subset of primary extramammary Paget disease (EMPD) may originate in anogenital mammary-like glands (AGMLG), the authors studied 181 specimens of EMPD, detailing alterations in AGMLG. The latter were identified in 33 specimens from 31 patients. All patients were women, ranging in age from 38 to 93 years (median, 65 y). Read More

    [Breast Cancer in Young Women - Correlation of Clinical Histomorphological, and Molecular-genetic Features of Breast Carcinoma in Women Younger than 35 Years of Age].
    Klin Onkol 2017 ;30(3):202-209
    Background: Worldwide, breast cancer is the leading type of malignancy in women. For premenopausal women, the disease brings much higher risk as it is usually more aggressive with worse prognosis.

    Patients And Methods: In this retrospective study, 92 women treated at the Department of Oncology and Radiotherapy in Pilsen were selected from a basic cohort of 356 women under 35 years of age with breast cancer who were diagnosed between 2006 and 2015. Read More

    Basal Cell Carcinoma Multiplicity - a Retrospective Analysis of 899 Biopsy-proven Patients from a Single Institute.
    Klin Onkol 2017 ;30(3):197-201
    Background: An interesting clinical feature of basal cell carcinoma (BCC) of the skin is a marked interpatient variation in tumor number, lesion accrual and anatomic distribution. We analyzed a proportion of patients with multiple BCCs in the cohort of pathology report-confirmed cases of BCC and investigated clinicopathological differences between individuals suffering from multiple tumor lesions and patients with a single tumor.

    Material And Methods: All consecutive patients with primary cutaneous BCCs, who were histologically diagnosed at our Department of Pathology during a 10-year period were enrolled into the study. Read More

    Chronic exposure to tetracyclines and subsequent diagnosis for non-melanoma skin cancer in a large Midwestern U.S. patient population.
    J Eur Acad Dermatol Venereol 2017 Jun 13. Epub 2017 Jun 13.
    Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
    Tetracyclines (TCNs) are commonly used in the management of several chronic dermatological disorders, partly due to their affinity for inflamed skin tissue, as they are known to suppress cytokines including tumor necrosis factor-alpha and interleukin-6 that are typically involved in inflammatory skin disorders.(1) TCNs are known to be photoreactive following ultraviolet (UV) radiation exposure, a known risk factor for the development of nonmelanoma skin cancer (NMSC), notably basal cell carcinoma (BCC) and squamous cell carcinoma (SCC).(2) Previous studies examining the relationship between photoreactive medications, including psoralen compounds and sulfonamide moieties, and NMSC suggest an association. Read More

    Circulating SCCA-IgM complex is a useful biomarker to predict the outcome of therapy in hepatocellular carcinoma patients.
    Scand J Clin Lab Invest 2017 Jun 13:1-6. Epub 2017 Jun 13.
    a Department of Clinical Medicine and Surgery, Gastroenterology Unit , University of Naples Federico II , Naples , Italy.
    Introduction: Hepatocellular carcinoma (HCC) develops in about 3-4% of cirrhotic patients every year. The squamous cell carcinoma antigen (SCCA) has been found elevated in liver cancer specimens by immunohistochemistry, and detected in complex with IgM (SCCA-IgM) in the serum of patients with HCC. The aim of this study was to evaluate the ability of serological SCCA-IgM levels to predict the efficacy of HCC therapy. Read More

    A Matching-Adjusted Indirect Comparison of Sonidegib and Vismodegib in Advanced Basal Cell Carcinoma.
    J Skin Cancer 2017 21;2017:6121760. Epub 2017 May 21.
    Novartis Pharmaceuticals Corporation, One Health Plaza, East Hanover, NJ, USA.
    Objectives: Based on single-arm trial data (BOLT), sonidegib was approved in the US and EU to treat locally advanced basal cell carcinomas (BCCs) ineligible for curative surgery or radiotherapy. Vismodegib, the other approved targeted therapy, also was assessed in a single-arm trial (ERIVANCE). We examined the comparative effectiveness of the two drugs using a matching-adjusted indirect comparison (MAIC) versus an unadjusted indirect comparison. Read More

    Establishment of a Clinic-based Biorepository.
    J Vis Exp 2017 May 29(123). Epub 2017 May 29.
    Affiliated Dermatology & Affiliated Laboratories, Midwestern University Osteopathic Postdoctoral Training Institute, Midwestern University.
    The incidence of skin cancer (e.g., squamous cell carcinoma, basal cell carcinoma, and melanoma) has been increasing over the past several years. Read More

    TRPC5-induced autophagy promotes drug resistance in breast carcinoma via CaMKKβ/AMPKα/mTOR pathway.
    Sci Rep 2017 Jun 9;7(1):3158. Epub 2017 Jun 9.
    Wuxi School of Medicine, Jiangnan University, Wuxi, China.
    Adriamycin is a first-line chemotherapy agent against cancer, but the development of resistance has become a major problem. Although autophagy is considered to be an adaptive survival response in response to chemotherapy and may be associated with chemoresistance, its inducer and the underlying molecular mechanisms remain unclear. Here, we demonstrate that adriamycin up-regulates the both levels of TRPC5 and autophagy, and the increase in autophagy is mediated by TRPC5 in breast cancer cells. Read More

    Molecularly targeted agents in oculoplastic surgery.
    Curr Opin Ophthalmol 2017 Jun 8. Epub 2017 Jun 8.
    Section of Ophthalmology, Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
    Purpose Of Review: Significant advances have been made in oncology and rheumatology with the introduction of molecularly targeted agents (MTAs). MTAs consist of monoclonal antibodies and small molecule inhibitors. The purpose of this manuscript is to review the recent applications of MTAs to orbital, lacrimal, and eyelid disease. Read More

    Volumetric arc therapy for total scalp irradiation: case report for a recurrent basal cell carcinoma of the scalp.
    Ecancermedicalscience 2017 11;11:737. Epub 2017 May 11.
    Innovative Cancer Institute, 5995 SW 71st Street, South Miami, FL 33143, USA.
    Total scalp irradiation may be used to treat numerous conditions including squamous and basal cell carcinomas. These conditions are relatively uncommon and patients are frequently treated with palliative intent. In this report, we describe a volumetric arc therapy technique using photon beams for curative intent in an 84 years old patient with recurrent basal cell carcinoma of the scalp. Read More

    Basaloid Squamous Cell Carcinoma of the Head and Neck: Subclassification into Basal, Ductal, and Mixed Subtypes Based on Comparison of Clinico-pathologic Features and Expression of p53, Cyclin D1, Epidermal Growth Factor Receptor, p16, and Human Papillomavirus
    J Pathol Transl Med 2017 06 8. Epub 2017 Jun 8.
    Department of Otorhinolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
    Background: Basaloid squamous cell carcinoma (BSCC) is a rare variant of squamous cell carcinoma with distinct pathologic characteristics. The histogenesis of BSCC is not fully understood, and the cancer has been suggested to originate from a totipotent primitive cell in the basal cell layer of the surface epithelium or in the proximal duct of secretory glands.

    Materials And Methods: Twenty-six cases of head and neck BSCC from Asan Medical Center, Seoul, Korea, reported during a 14-year-period were subclassified into basal, ductal, and mixed subtypes according to the expression of basal (cytokeratin [CK] 5/6, p63) or ductal markers (CK7, CK8/18). Read More

    Investigation of P120catenin Expression in Human Basal Cell Carcinoma of the Skin.
    Acta Medica (Hradec Kralove) 2017 ;60(1):32-36
    Department of Dermatovenerology, Faculty Hospital in Žilina, V. Spanyola 43, Žilina, Slovakia.
    Background: P120(ctn) is a specific membranous adhesion protein, that maintains the stability of intercellular junctions. An altered expression of p120(ctn), either reduced in the cell membrane or increase in the cytoplasm, plays a crucial role in carcinogenesis. No research has analysed the expression of p120(ctn) in basal cell carcinoma (BCC) of the skin so far. Read More

    Retrospective evaluation of exposure to natural UV radiation: experiences with the online UV history tool in a field study.
    J Dtsch Dermatol Ges 2017 Jun;15(6):610-619
    Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine at the University of Erlangen-Nuremberg (FAU), Erlangen, Germany.
    Background: Cutaneous squamous cell carcinoma and multiple actinic keratoses can be recognized as occupational diseases if the site affected has been subjected to additional occupational UV exposure of at least 40 %. An online UV history tool that allows for the quantification of occupational and recreational UV doses was now tested in a field study.

    Patients And Methods: Ninety-nine patients with nonmelanoma skin cancer were examined. Read More

    Cutaneous Squamous Cell Carcinoma: Review of the Eighth Edition of the American Joint Committee on Cancer Staging Guidelines, Prognostic Factors, and Histopathologic Variants.
    Adv Anat Pathol 2017 Jul;24(4):171-194
    *Department of Dermatology, University of Florida College of Medicine, Gainesville, FL †Miraca Life Sciences Research Institute, Irving, TX ‡Miraca Life Sciences Research Institute, Newton, and Department of Dermatology at Tufts Medical Center, Boston, MA.
    Cutaneous squamous cell carcinoma is the second most common form of nonmelanoma skin cancer after basal cell carcinoma and accounts for the majority of nonmelanoma skin cancer-related deaths. In 2017, the American Joint Committee on Cancer revised the staging guidelines of cutaneous squamous cell carcinoma to reflect recent evidence concerning high-risk clinicopathologic features. This update reviews the literature on prognostic features and staging, including the eighth edition of the American Joint Committee on Cancer Staging Manual. Read More

    Cutaneous Malignancies Simulating Seborrheic Keratoses: An Underappreciated Phenomenon?
    J Cutan Pathol 2017 Jun 7. Epub 2017 Jun 7.
    Cockerell Dermatopathology, Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX.
    Background: Seborrheic keratosis (SK), a common and benign entity, is generally diagnosed clinically without the need for a biopsy. Given their variable appearance, SK may mimic cancer clinically and require biopsy for clinically equivocal cases. A clinician may also choose to perform biopsies on SK based on other circumstances, such as cosmetic reasons, or SK being in an inconvenient and irritative location. Read More

    Risk factors for recurrence of facial basal cell carcinoma after surgical excision: A follow-up analysis.
    J Plast Reconstr Aesthet Surg 2017 May 3. Epub 2017 May 3.
    University of New England, School of Rural Medicine, Armidale, NSW, Australia.
    Background: Several tumour features and surgical factors have been implicated in an increased risk of BCC recurrence after excision; however, there are limited data on facial lesions specifically. This study sought to evaluate risk factors of facial BCC, which may influence future treatment and follow-up regimes.

    Methods: Facial BCCs excised from a single surgeon practice over a 2-year period were included in the study. Read More

    Xeroderma pigmentosum at a tertiary care center in Saudi Arabia.
    Ann Saudi Med 2017 May-Jun;37(3):240-244
    Lenah Alwatban, Department of Dermatology,, MBC 104, King Faisal Specialist Hospital and Research Centre,, PO Box 3354 Riyadh 11211,, Saudi Arabia, T: +966569450282 ORCID:
    Background: Xeroderma pigmentosum (XP) is a rare autosomal recessive disorder caused by defective DNA repair that results in extreme sensitivity to ultraviolet (UV) rays. Depending on the type of XP, the disease may affect the skin, eyes and nervous system.

    Objectives: Describe the dermatologic manifestations in patients suffering from XP. Read More

    Differential Regulation of Monocarboxylate Transporter 8 Expression in Thyroid Cancer and Hyperthyroidism.
    Eur J Endocrinol 2017 Jun 2. Epub 2017 Jun 2.
    D Zwanziger, Department of Endocrinology and Metabolism, Universitatsklinikum Essen, Essen, 45122, Germany
    Objective: Thyroid hormone (TH) transporters are expressed in thyrocytes and most likely/putatively may play a role in TH-release. We asked whether expression of the monocarboxylate transporter 8 (MCT8) and the L-type amino acid transporters LAT2 and LAT4 is changed with thyrocyte dedifferentiation and in hyperfunctioning thyroid tissues.

    Design And Methods: Protein expression and localization of transporters was determined by immunohistochemistry in human thyroid specimen including normal thyroid tissue (NT, n=19), follicular adenoma (FA, n=44), follicular thyroid carcinoma (FTC, n=45), papillary thyroid carcinoma (PTC, n=40), anaplastic thyroid carcinoma (ATC, n=40) and Graves' disease (GD, n=50) by calculating the 'hybrid' (H) score. Read More

    Basal cell carcinoma pathogenesis and therapy involving hedgehog signaling and beyond.
    Mol Carcinog 2017 Jun 2. Epub 2017 Jun 2.
    Department of Dermatology and Skin Diseases Research Center, University of Alabama at Birmingham, Birmingham, AL, USA.
    Basal cell carcinoma (BCC) of the skin is driven by aberrant hedgehog signaling. Thus blocking this signaling pathway by small molecules such as vismodegib inhibits tumor growth. Primary cilium in the epidermal cells plays an integral role in the processing of hedgehog signaling related proteins. Read More

    Pruritus in epithelial tumors of the face.
    J Eur Acad Dermatol Venereol 2017 Jun 2. Epub 2017 Jun 2.
    Department of Dermatology, School of Medicine, Pusan National University, Busan, Republic of Korea.
    Although most skin tumors are known to be asymptomatic, patients frequently complain of pruritus. However, only few studies have investigated pruritus developing in skin tumors. The aim of this study was to assess the prevalence and characteristics of pruritus in skin tumors. Read More

    Cost-effectiveness of Early Division of the Forehead Flap Pedicle.
    JAMA Facial Plast Surg 2017 Jun 1. Epub 2017 Jun 1.
    Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California.
    Importance: The paramedian forehead flap is considered the gold standard procedure to optimally reconstruct major defects of the nose, but this procedure generally requires 2 stages, where the flap pedicle is divided 3 weeks following the initial surgery to ensure adequate revascularization of the flap from the surrounding recipient tissue bed, which can cost a patient time out of work or away from normal social habits. It has previously been shown that the pedicle may be safely divided after 2 weeks in select patients where revascularization from the recipient bed was confirmed using intraoperative laser fluorescence angiography to potentially save the patient time and money.

    Objective: To demonstrate the cost-effectiveness of takedown of the paramedian forehead flap pedicle after 2 weeks using angiography with indocyanine green (ICG). Read More

    Optical biopsy approach to basal cell carcinoma and melanoma based on all-optically integrated photoacoustic and optical coherence tomography.
    Opt Lett 2017 Jun;42(11):2145-2148
    Basal cell carcinoma (BCC) and melanoma (MM), with the highest morbidity and mortality, respectively, are considered as two skin cancers of concern in dermatology. Histological studies have demonstrated that vascular patterns and collagenous stroma serve as key parameters for BCC and MM classification. In this Letter, we sought to identify BCC and MM based on the dual parameters of vascular patterns and scattering structures provided by all-optically integrated photoacoustic and optical coherence tomography (AOPA/OCT). Read More

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