28,400 results match your criteria Epitheliomas Basal Cell


Margin-Controlled, Staged Surgical Excision in the Treatment of High-Risk Basal Cell Carcinomas of the Head and Neck Region.

J Cutan Med Surg 2018 Dec 17:1203475418820868. Epub 2018 Dec 17.

2 Department of Plastic Reconstructive and Aesthetic Surgery, Marmara University School of Medicine, Istanbul, Turkey.

Background:: The most common skin cancer is basal cell carcinoma (BCC), and the gold-standard treatment for high-risk tumours is Mohs surgery. However, alternative methods are needed for high-risk tumours in countries where the performance rate of Mohs surgery is low.

Objectives:: The objective of this article is to investigate the feasibility, efficacy, and safety of margin-controlled, staged surgical excision (MCSSE) in high-risk tumours as a possible treatment alternative. Read More

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http://dx.doi.org/10.1177/1203475418820868DOI Listing
December 2018
1 Read

Clinical and molecular characteristics of bladder urothelial carcinoma subtypes.

J Cell Biochem 2018 Dec 12. Epub 2018 Dec 12.

Department of Organization, General Hospital of Benxi Iron and Steel Co., Benxi, China.

Bladder urothelial carcinoma (BLCA) is a common malignancy with high heterogeneity. A reasonable molecular subtyping can facilitate biological study and personalized therapy of BLCA. In this study, unsupervised consensus clustering was used to acquire the molecular subtypes of BLCA based on messenger RNA (mRNA) and microRNA (miRNA) data. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jcb.28278
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http://dx.doi.org/10.1002/jcb.28278DOI Listing
December 2018
3 Reads

Bile salt (glycochenodeoxycholate acid) induces cell survival and chemoresistance in hepatocellular carcinoma.

J Cell Physiol 2018 Dec 12. Epub 2018 Dec 12.

Key Laboratory of Nanobiological Technology of Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.

Objective: Glycochenodeoxycholate acid (GCDA) is a toxic component in bile salts. It plays an important role in the development and progression of liver cancer. In this study, we investigated the underlying mechanism of GCDA in hepatocarcinogenesis and chemotherapy resistance. Read More

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http://dx.doi.org/10.1002/jcp.27905DOI Listing
December 2018

Modifiable Risk-factors for Keratinocyte Cancers in Australia: A Case-control Study.

Acta Derm Venereol 2018 Dec 13. Epub 2018 Dec 13.

Department of Clinical Epidemiology and Applied Biostatistics, University Hospital Tübingen, DE-72076 Tübingen, Germany.

Keratinocyte cancer (KC) is the most common malignancy in Caucasians. The incidence of KC has increased over the past 40 years. This case-control study investigated the environmental and host risk-factors responsible for development of KC in Australia's high-risk population. Read More

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http://dx.doi.org/10.2340/00015555-3107DOI Listing
December 2018
1 Read

Factors associated with suspected nonmelanoma skin cancers, dysplastic nevus, and cutaneous melanoma among first-time SPOTme screening program participants (2009-2010).

J Am Acad Dermatol 2018 Dec 10. Epub 2018 Dec 10.

Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA. Electronic address:

Background: There have been no studies of the American Academy of Dermatology's SPOTme skin cancer screening program that have collectively analyzed the factors associated with suspected diagnoses of basal cell carcinoma (BCC), squamous cell carcinoma (SCC), dysplastic nevus (DN), and cutaneous melanoma (CM).

Objective: Describe the demographics, risk factors, and access to care profile associated with suspected diagnoses of BCC, SCC, DN, and CM among first-time SPOTme screenees from 2009 to 2010.

Methods: We conducted a cross-sectional analysis of data from SPOTme skin cancer screenings conducted in 2009 and 2010. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.12.010DOI Listing
December 2018

Triazoles bind the C-terminal domain of SMO: Illustration by docking and molecular dynamics simulations the binding between SMO and triazoles.

Life Sci 2018 Dec 10. Epub 2018 Dec 10.

Department of Medical Mycology, Institute of Dermatology, Chinese Academy of Medical Science and Peking Union Medical College, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, Jiangsu, China. Electronic address:

Itraconazole is an antagonist of the component Smoothened of Hedgehog pathway, which can inhibit the growth of medulloblastoma, basal cell carcinoma, and melanoma, etc. To research the binding mechanism of the Smoothened and triazoles, we used docking and molecular dynamics simulations on the Smoothened crystal structure and six triazoles. Unlike vismodegib, itraconazole can effectively bind into the pocket in the C-terminal domain of the Smoothened crystal structure instead of the N-terminal domain. Read More

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http://dx.doi.org/10.1016/j.lfs.2018.12.012DOI Listing
December 2018

Merkel Cell Carcinoma in the HIV-1/AIDS Patient.

Cancer Treat Res 2019 ;177:211-229

Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, 02215, USA.

Merkel cell carcinoma (MCC) is a highly aggressive, primary neuroendocrine cancer of the skin. The majority of MCC cases are associated with the recently discovered Merkel cell polyomavirus (MCPyV), while the remaining are caused by ultraviolet (UV) light-induced mutations from excessive sunlight exposure. The risk of developing MCC is much higher in the white population relative to all other races. Read More

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http://dx.doi.org/10.1007/978-3-030-03502-0_8DOI Listing
January 2019

Keratinocyte Carcinomas: Current concepts and future research priorities.

Clin Cancer Res 2018 Dec 6. Epub 2018 Dec 6.

Department of Cancer Biology and Genetics and Division of Human Genetics, Department of Internal Medicine, Ohio State University

Cutaneous squamous cell carcinoma (cSCC) and basal cell carcinoma (BCC) are keratinocyte carcinomas (KC), the most frequently diagnosed cancers in fair-skinned populations. Ultraviolet radiation (UVR) is the main driving carcinogen for these tumors but immunosuppression, pigmentary factors, and aging are also risk factors. Scientific discoveries have improved the understanding of the role of human papillomaviruses (HPV) in cSCC as well as the skin microbiome and a compromised immune system in the development of both cSCC and BCC. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-1122DOI Listing
December 2018
8.722 Impact Factor

Hedgehog Pathway Inhibitors and Their Utility in Basal Cell Carcinoma: A Comprehensive Review of Current Evidence.

Dermatol Ther (Heidelb) 2018 Dec 11. Epub 2018 Dec 11.

Department of Plastic Surgery, Tan Tock Seng Hospital, Singapore, Republic of Singapore.

Basal cell carcinoma (BCC) is the most commonly diagnosed malignancy in humans, and as such it poses a significant healthcare burden. The majority of BCC cases are amenable to cure by surgical extirpation. However, until recently there have been no good treatment options for a significant minority of advanced BCC cases, including locally advanced BCC and metastatic BCC. Read More

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http://dx.doi.org/10.1007/s13555-018-0277-7DOI Listing
December 2018
1 Read

Recurrence of periocular basal and squamous cell carcinoma after Mohs Micrographic Surgery: a retrospective cohort study.

Br J Dermatol 2018 Dec 11. Epub 2018 Dec 11.

Department of dermatology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.

Background: Despite the widespread use of Mohs Micrographic Surgery (MMS) for periocular basal and squamous cell carcinoma (together called keratinocyte carcinoma (KC)), follow-up data regarding recurrences are limited.

Objectives: To investigate the recurrence rate for periocular KCs after MMS and describe experience with interdisciplinary collaborations.

Methods: Patients with periocular KCs treated with MMS between 2006 and 2016 in a tertiary MMS referral hospital were included in this retrospective cohort study. Read More

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http://dx.doi.org/10.1111/bjd.17516DOI Listing
December 2018

Malignant eyelid tumors: Are intra-operative rapid frozen section and permanent section diagnoses of surgical margins concordant?

Int Ophthalmol 2018 Dec 8. Epub 2018 Dec 8.

Ophthalmic Pathology Laboratory (DKM), L V Prasad Eye Institute, Hyderabad, India.

Purpose: To study the concordance between intra-operative rapid frozen section and permanent section diagnoses of surgical margins following wide surgical excisional biopsy of malignant eyelid tumors.

Methods: This is a retrospective study of 120 cases and 429 frozen section slides.

Results: Of 120 cases, 75 (63%) had sebaceous gland carcinoma, 34 (28%) had basal cell carcinoma, and 11 (9%) had squamous cell carcinoma. Read More

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http://dx.doi.org/10.1007/s10792-018-1058-0DOI Listing
December 2018

Basal cell carcinoma and basosquamous carcinoma, two faces of the same condition?

Rom J Morphol Embryol 2018 ;59(3):989-996

Department of Microscopic Morphology, "Victor Babeş" University of Medicine and Pharmacy, Timişoara, Romania; Department of Otorhinolaryngology, "Victor Babeş" University of Medicine and Pharmacy, Timişoara, Romania;

Basal cell carcinoma (BCC) is the most common locally invasive malignant epidermal neoplasm. It is generally a tumor that runs a slow progressive course and can usually be cured by surgery. Basosquamous carcinoma is considered by some authors a rare subtype of BCC, while others describe it as independent tumor with different evolution from BCC. Read More

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January 2018

Mixed (nodular and morpheic) upper eyelid basal cell carcinoma with orbital invasion - histological and clinical features.

Rom J Morphol Embryol 2018 ;59(3):977-983

Department of Plastic Surgery, "Grigore T. Popa" University of Medicine and Pharmacy, Iaşi, Romania;

Basal cell carcinoma (BCC) is the most common type of cancer located in the periocular area. We will present the clinical case of a 63-year-old male patient who was admitted to the 2nd Clinic of Neurosurgery, "Prof. Dr. Read More

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January 2018
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The prognostic value of CXCR4, α-SMA and WASL in upper lip basal cell carcinomas.

Rom J Morphol Embryol 2018 ;59(3):839-849

Department of Dental Materials, Faculty of Dentistry, University of Medicine and Pharmacy of Craiova, Romania;

Lip cancers account for 10-12% of the total head and neck cancers and, although squamous cell carcinoma is by far the most common lower lip cancer, the basal cell carcinoma (BCC) seems to be more common for the upper lip. Most BCCs have a clinically indolent behavior, but there are also local aggressive and∕or metastatic cases, with the incidence of such cases being estimated at about 1-10% of all cases of BCC. Many of the molecular mechanisms underlying this aggression are still unknown, which is why our study aimed to investigate the potential prognosis of a few markers, such as C-X-C chemokine receptor type 4 (CXCR4), alpha-smooth muscle actin (α-SMA) and Wiskott-Aldrich syndrome like (WASL) in upper lip BCCs. Read More

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January 2018
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Ultrasonographic features of superficial and nodular basal cell carcinoma.

Med Ultrason 2018 Dec;20(4):475-479

M.F. Vladimirsky Moscow Regional Scientific Research Clinical Institute, Scientific-Practical Center of Dermatovenerology and Cosmetology, Moscow, Russia.

Aim: To describe the ultrasonographic findings of surface and nodular basal cell skin cancer (BCC) using high frequency ultrasonography.

Materials And Methods: We examined 60 primary BCCs in different locations with the High Frequency Ultrasound (HFU) system DUB Skin Scanner using 75 MHz and 30 MHz probes. Epidermis, dermis, and depth of tumors spread in the region of interest (ROI) were measured. Read More

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December 2018
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Fourth Dimension in Reconstruction of Defects Following Excision of Basal Cell Carcinoma of Head and Neck!

J Cutan Aesthet Surg 2018 Jul-Sep;11(3):110-119

Department of Plastic Reconstructive and Faciomaxillary Surgery, Madras Medical College, Chennai, Tamil Nadu, India.

Background: Basal cell carcinomas (BCCs) are the most common skin tumors of the face. Excision results in soft tissue defects that require reconstruction with the focus on form, function, and patient satisfaction.

Aim: To analyze the reconstruction of BCC excision defects of the head and neck region using local flaps and skin grafts with respect to the four dimensions of oncological reconstruction: clearance, form, function, and patient satisfaction. Read More

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http://dx.doi.org/10.4103/JCAS.JCAS_100_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243820PMC
December 2018

Metatypical Basal Cell Carcinoma with Intravascular Invasion.

Cureus 2018 Oct 2;10(10):e3401. Epub 2018 Oct 2.

Dermatology, University of Central Florida College of Medicine, Orlando, USA.

Basal cell carcinoma is the most common malignancy worldwide, but it very rarely metastasizes. Perineural invasion in basal cell carcinoma has been well documented in the literature, but evidence of intravascular invasion has rarely been reported. We describe a rare case of metatypical basal cell carcinoma with intravascular invasion and discuss the clinical management associated with this presentation. Read More

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http://dx.doi.org/10.7759/cureus.3401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279002PMC
October 2018

Curettage and multiple needle puncture-assisted methyl-aminolaevulinate photodynamic therapy of basal cell carcinoma.

Eur J Dermatol 2018 Dec 10. Epub 2018 Dec 10.

University of Northern Norway, Institute of Clinical Medicine, Tromsø, Norway, Lillehammer Dermatological Clinic, Lillehammer, Norway.

The use of skin puncture techniques may facilitate the delivery of topically applied drugs for photodynamic therapy (PDT). The main aim of this prospective study was to evaluate the efficacy and cosmetic outcome of curettage, multiple needle puncture, and methyl-aminolaevulinate (MAL)-PDT in basal cell carcinoma (BCC). All tumours received curettage and 15-20 needle punctures/cm before two sessions of MAL-PDT. Read More

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http://dx.doi.org/10.1684/ejd.2018.3445DOI Listing
December 2018

Reflectance confocal microscopy terminology glossary for non-melanocytic skin lesions: A systematic review.

J Am Acad Dermatol 2018 Dec 7. Epub 2018 Dec 7.

Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA. Electronic address:

Background: There is lack of uniformity in reflectance confocal microscopy (RCM) terminology for non-melanocytic lesions (NMLs).

Objective: To review published RCM terms for NMLs and identify likely-synonymous terms.

Methods: Systematic review of original research articles adhering to PRISMA guidelines was conducted until August 19, 2017. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.12.007DOI Listing
December 2018
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Development of posaconazole-based analogues as hedgehog signaling pathway inhibitors.

Eur J Med Chem 2018 Nov 23;163:320-332. Epub 2018 Nov 23.

Department of Pharmaceutical Sciences, University of Connecticut, 69 N Eagleville Rd, Unit 3092, Storrs, CT, 06269, USA. Electronic address:

Inhibition of the hedgehog (Hh) signaling pathway has been validated as a therapeutic strategy to treat basal cell carcinoma and holds potential for several other forms of human cancer. Itraconazole and posaconazole are clinically useful triazole anti-fungals that are being repurposed as anti-cancer agents based on their ability to inhibit the Hh pathway. We have previously demonstrated that removal of the triazole from itraconazole does not affect its ability to inhibit the Hh pathway while abolishing its primary side effect, potent inhibition of Cyp3A4. Read More

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http://dx.doi.org/10.1016/j.ejmech.2018.11.056DOI Listing
November 2018

Evaluating the landscape of gene cooperativity with receptor tyrosine kinases in liver tumorigenesis using transposon-mediated mutagenesis.

J Hepatol 2018 Dec 5. Epub 2018 Dec 5.

Aix Marseille Univ, CNRS, Developmental Biology Institute of Marseille (IBDM) UMR 7288, Parc Scientifique de Luminy, Marseille France. Electronic address:

Background & Aims: The variety of alterations found in hepatocellular carcinoma (HCC) challenges the identification of functionally relevant genes and their combinatorial actions in tumorigenesis. Deregulation of Receptor Tyrosine Kinases (RTKs) is frequent in HCC, yet little is known about the molecular events that cooperate with RTKs and whether these cooperative events play an active role at the root of liver tumorigenesis.

Methods: A forward genetic screen was performed using Sleeping Beauty transposon insertional mutagenesis to accelerate liver tumour formation in a genetic context in which subtly increased MET RTK levels predispose towards tumorigenesis. Read More

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http://dx.doi.org/10.1016/j.jhep.2018.11.027DOI Listing
December 2018

Computer-assisted diagnosis techniques (dermoscopy and spectroscopy-based) for diagnosing skin cancer in adults.

Cochrane Database Syst Rev 2018 Dec 3;12:CD013186. Epub 2018 Dec 3.

Institute of Applied Health Research, University of Birmingham, Edgbaston Campus, Birmingham, UK, B15 2TT.

Background: Early accurate detection of all skin cancer types is essential to guide appropriate management and to improve morbidity and survival. Melanoma and cutaneous squamous cell carcinoma (cSCC) are high-risk skin cancers which have the potential to metastasise and ultimately lead to death, whereas basal cell carcinoma (BCC) is usually localised with potential to infiltrate and damage surrounding tissue. Anxiety around missing early curable cases needs to be balanced against inappropriate referral and unnecessary excision of benign lesions. Read More

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http://doi.wiley.com/10.1002/14651858.CD013186
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http://dx.doi.org/10.1002/14651858.CD013186DOI Listing
December 2018
5 Reads

Optical coherence tomography for diagnosing skin cancer in adults.

Cochrane Database Syst Rev 2018 Dec 3;12:CD013189. Epub 2018 Dec 3.

Institute of Applied Health Research, University of Birmingham, Edgbaston Campus, Birmingham, UK, B15 2TT.

Background: Early accurate detection of all skin cancer types is essential to guide appropriate management and to improve morbidity and survival. Melanoma and squamous cell carcinoma (SCC) are high-risk skin cancers, which have the potential to metastasise and ultimately lead to death, whereas basal cell carcinoma (BCC) is usually localised, with potential to infiltrate and damage surrounding tissue. Anxiety around missing early cases needs to be balanced against inappropriate referral and unnecessary excision of benign lesions. Read More

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http://doi.wiley.com/10.1002/14651858.CD013189
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http://dx.doi.org/10.1002/14651858.CD013189DOI Listing
December 2018
9 Reads

Exfoliative cytology for diagnosing basal cell carcinoma and other skin cancers in adults.

Cochrane Database Syst Rev 2018 Dec 3;12:CD013187. Epub 2018 Dec 3.

Institute of Applied Health Research, University of Birmingham, Edgbaston Campus, Birmingham, UK, B15 2TT.

Background: Early accurate detection of all skin cancer types is essential to guide appropriate management, reduce morbidity and improve survival. Basal cell carcinoma (BCC) is usually localised to the skin but has potential to infiltrate and damage surrounding tissue, while cutaneous squamous cell carcinoma (cSCC) and melanoma have a much higher potential to metastasise and ultimately lead to death. Exfoliative cytology is a non-invasive test that uses the Tzanck smear technique to identify disease by examining the structure of cells obtained from scraped samples. Read More

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http://doi.wiley.com/10.1002/14651858.CD013187
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http://dx.doi.org/10.1002/14651858.CD013187DOI Listing
December 2018
8 Reads

Visual inspection and dermoscopy, alone or in combination, for diagnosing keratinocyte skin cancers in adults.

Cochrane Database Syst Rev 2018 Dec 3;12:CD011901. Epub 2018 Dec 3.

Institute of Applied Health Research, University of Birmingham, Birmingham, UK, B15 2TT.

Background: Early accurate detection of all skin cancer types is important to guide appropriate management, to reduce morbidity and to improve survival. Basal cell carcinoma (BCC) is almost always a localised skin cancer with potential to infiltrate and damage surrounding tissue, whereas a minority of cutaneous squamous cell carcinomas (cSCCs) and invasive melanomas are higher-risk skin cancers with the potential to metastasise and cause death. Dermoscopy has become an important tool to assist specialist clinicians in the diagnosis of melanoma, and is increasingly used in primary-care settings. Read More

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http://dx.doi.org/10.1002/14651858.CD011901.pub2DOI Listing
December 2018
5 Reads

Reflectance confocal microscopy for diagnosing keratinocyte skin cancers in adults.

Cochrane Database Syst Rev 2018 Dec 3;12:CD013191. Epub 2018 Dec 3.

Institute of Applied Health Research, University of Birmingham, Birmingham, UK, B15 2TT.

Background: Early accurate detection of all skin cancer types is important to guide appropriate management and improve morbidity and survival. Basal cell carcinoma (BCC) is usually a localised skin cancer but with potential to infiltrate and damage surrounding tissue, whereas cutaneous squamous cell carcinoma (cSCC) and melanoma are higher risk skin cancers with the potential to metastasise and ultimately lead to death. When used in conjunction with clinical or dermoscopic suspicion of malignancy, or both, reflectance confocal microscopy (RCM) may help to identify cancers eligible for non-surgical treatment without the need for a diagnostic biopsy, particularly in people with suspected BCC. Read More

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http://doi.wiley.com/10.1002/14651858.CD013191
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http://dx.doi.org/10.1002/14651858.CD013191DOI Listing
December 2018
6 Reads

Teledermatology for diagnosing skin cancer in adults.

Cochrane Database Syst Rev 2018 Dec 3;12:CD013193. Epub 2018 Dec 3.

Institute of Applied Health Research, University of Birmingham, Birmingham, UK, B15 2TT.

Background: Early accurate detection of all skin cancer types is essential to guide appropriate management and to improve morbidity and survival. Melanoma and squamous cell carcinoma (SCC) are high-risk skin cancers which have the potential to metastasise and ultimately lead to death, whereas basal cell carcinoma (BCC) is usually localised with potential to infiltrate and damage surrounding tissue. Anxiety around missing early curable cases needs to be balanced against inappropriate referral and unnecessary excision of benign lesions. Read More

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http://doi.wiley.com/10.1002/14651858.CD013193
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http://dx.doi.org/10.1002/14651858.CD013193DOI Listing
December 2018
9 Reads

High-frequency ultrasound for diagnosing skin cancer in adults.

Cochrane Database Syst Rev 2018 Dec 3;12:CD013188. Epub 2018 Dec 3.

Institute of Applied Health Research, University of Birmingham, Birmingham, UK, B15 2TT.

Background: Early, accurate detection of all skin cancer types is essential to guide appropriate management and to improve morbidity and survival. Melanoma and squamous cell carcinoma (SCC) are high-risk skin cancers with the potential to metastasise and ultimately lead to death, whereas basal cell carcinoma (BCC) is usually localised, with potential to infiltrate and damage surrounding tissue. Anxiety around missing early curable cases needs to be balanced against inappropriate referral and unnecessary excision of benign lesions. Read More

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http://doi.wiley.com/10.1002/14651858.CD013188
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http://dx.doi.org/10.1002/14651858.CD013188DOI Listing
December 2018
7 Reads

Fresh/frozen Tübingen technique (Margin strip method) for head and neck basal cell carcinoma: A retrospective study of 298 cases.

Authors:
Roberto Cecchi

Dermatol Ther 2018 Dec 6:e12799. Epub 2018 Dec 6.

Department of Dermatology, San Jacopo Hospital, V. Ciliegiole 1, 51100 Pistoia, Italy.

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http://dx.doi.org/10.1111/dth.12799DOI Listing
December 2018
2 Reads

Non-genetic and genetic predictors of a superficial first basal cell carcinoma.

J Eur Acad Dermatol Venereol 2018 Dec 6. Epub 2018 Dec 6.

Department of Dermatology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.

Background: several observational studies have suggested differences in the risk factor profile between patients with superficial basal cell carcinomas (BCCs) and non-superficial BCCs.

Objective: to test the reproducibility of previous study findings and to find new genetic and non-genetic predictors for patients with a superficial first BCC.

Methods: 14. Read More

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http://dx.doi.org/10.1111/jdv.15389DOI Listing
December 2018
3 Reads

Periocular basal cell carcinoma in under 40's - Is more aggressive treatment warranted?

Eye (Lond) 2018 Dec 5. Epub 2018 Dec 5.

Princess Alexandra Eye Pavilion, Chalmers Street, Edinburgh, EH3 9HA, NHS Lothian, UK.

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http://dx.doi.org/10.1038/s41433-018-0290-1DOI Listing
December 2018

Bexarotene - a novel modulator of AURKA and the primary cilium in -deficient cells.

J Cell Sci 2018 Dec 14;131(24). Epub 2018 Dec 14.

Center for Precision Environmental Health, Baylor College of Medicine, Houston, TX 77030, USA

Loss of the gene von Hippel-Lindau () is associated with loss of primary cilia and is causally linked to elevated levels of Aurora kinase A (AURKA). We developed an image-based high-throughput screening (HTS) assay using a dual-labeling image analysis strategy that identifies both the cilium and the basal body. By using this strategy, we screened small-molecule compounds for the targeted rescue of cilia defects associated with deficiency with high accuracy and reproducibility. Read More

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http://dx.doi.org/10.1242/jcs.219923DOI Listing
December 2018
1 Read

Crystal Structures and Cytotoxicity of ent-Kaurane-Type Diterpenoids from Two Aspilia Species.

Molecules 2018 Dec 4;23(12). Epub 2018 Dec 4.

Department of Chemistry, University of Nairobi, P. O. Box 30197, 00100 Nairobi, Kenya.

A phytochemical investigation of the roots of led to the isolation of -kaurane-type diterpenoids and additional phytochemicals (⁻). The structures of the isolated compounds were elucidated based on Nuclear Magnetic Resonance (NMR) spectroscopic and mass spectrometric analyses. The absolute configurations of seven of the -kaurane-type diterpenoids (⁻, and ) were determined by single crystal X-ray diffraction studies. Read More

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http://dx.doi.org/10.3390/molecules23123199DOI Listing
December 2018
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Outcomes of long-pulsed 1064 nm Nd:YAG laser treatment of basal cell carcinoma: A retrospective review.

Lasers Surg Med 2018 Dec 3. Epub 2018 Dec 3.

Department of Dermatology, University of California, San Diego School of Medicine, 9500 Gillman Drive, La Jolla, California, 92093.

Background And Objective: Recent prospective trials have supported treatment of nonfacial BCC with long-pulsed 1064 nm Nd:YAG laser based on short-term histologic clearance rates. Studies have yet to identify the long-term clinical clearance rates of this specific laser therapy for BCC.

Study Design/material And Methods: This is a retrospective review of BCC treated with long-pulsed 1064 nm Nd:YAG laser, which have been clinically monitored for at least 6 months, to assess for recurrence and cosmetic outcomes of the treated area. Read More

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http://dx.doi.org/10.1002/lsm.23041DOI Listing
December 2018

Shedding light on photodynamic therapy for basal cell carcinoma.

Authors:
Henry W Lim

Br J Dermatol 2018 Dec;179(6):1240-1241

Department of Dermatology, Henry Ford Hospital, Henry Ford Medical Center - New Center One, 3031 West Grand Blvd, Suite 800, Detroit, MI, 48202, U.S.A.

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http://dx.doi.org/10.1111/bjd.17187DOI Listing
December 2018

Basal cell carcinoma of the vulva: a case report and systematic review of the literature.

Int J Dermatol 2018 Dec 2. Epub 2018 Dec 2.

Department of Dermatology, Beth Israel Deaconess Medical Center, Boston, MA, USA.

The vulva is an unusual site for basal cell carcinoma (BCC). Vulvar BCC accounts for <1% of all BCCs and <5% of all vulvar malignancies. We report the case of an 83 year-old woman who presented with a 2-month history of a tender labial growth, with histopathology confirming nodular BCC. Read More

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http://dx.doi.org/10.1111/ijd.14307DOI Listing
December 2018

LAP2 Proteins Chaperone GLI1 Movement between the Lamina and Chromatin to Regulate Transcription.

Cell 2018 Nov 27. Epub 2018 Nov 27.

Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

Understanding transcription factor navigation through the nucleus remains critical for developing targeted therapeutics. The GLI1 transcription factor must maintain maximal Hedgehog pathway output in basal cell carcinomas (BCCs), and we have previously shown that resistant BCCs increase GLI1 deacetylation through atypical protein kinase Cι/λ (aPKC) and HDAC1. Here we identify a lamina-associated polypeptide 2 (LAP2) isoform-dependent nuclear chaperoning system that regulates GLI1 movement between the nuclear lamina and nucleoplasm to achieve maximal activation. Read More

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http://dx.doi.org/10.1016/j.cell.2018.10.054DOI Listing
November 2018

Incidence of non-melanoma skin cancer in patients treated with psoralen and ultraviolet A therapy.

Med Clin (Barc) 2018 Nov 29. Epub 2018 Nov 29.

Servicio de Dermatología, Hospital General Universitario de Valencia, Valencia, España; Facultad de Medicina, Universitat de València, Valencia, España.

Introduction: Studies reporting incidences of non-melanoma skin cancer (NMSC) are heterogeneous, depend on the geographic area of the studied population and are often short-term. The aim of this study is to determine the incidence of NMSC in patients treated with oral PUVA therapy in the Mediterranean area.

Material And Methods: A retrospective, observational study was carried out with a sample of 234 patients treated with systemic PUVA between 1982 and 1996, carrying out a historical follow-up until May 2017. Read More

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http://dx.doi.org/10.1016/j.medcli.2018.09.018DOI Listing
November 2018
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Mass spectrometric imaging of cysteine rich proteins in human skin.

Int J Biol Macromol 2018 Dec 2. Epub 2018 Dec 2.

Department of Chemistry and Biochemistry, Mendel University in Brno, Brno, Czech Republic; Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic. Electronic address:

Looking insight pathological processes, metallothioneins (MTs) are considered to be potential biomarkers for monitoring of a development of various types of malignant disease, such as cancer. The early identification of the MT biomarkers in biological tissues could be important tool for the estimation of appropriate clinical therapy. Therefore here we investigated the application of matrix assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) together with immunohistochemical analyses (IHC) using MT-1/2 antibody for MT detection in formalin-fixed paraffin-embedded (FFPE) biopsy specimens of human skin. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2018.11.272DOI Listing
December 2018
4 Reads

Muir-Torre Syndrome With a Frame-shift Mutation in the MSH2 Gene: A Rare Case Report and Literature Review.

Int J Gynecol Pathol 2018 Dec 3. Epub 2018 Dec 3.

Department of Pathology, Wuhan University Zhongnan Hospital, and Wuhan University Center for Pathology and Molecular Diagnostics (Q.C., Z.X., S.T., S.X.) Department of Pathology, Hubei Cancer Hospital (Manxiang W., S.J., Mingwei W.), Wuhan, Hubei Province, China Department of Pathology, University of Chicago, Chicago, Illinois (S.X.).

Muir-Torre syndrome is a rare subtype of Lynch syndrome characterized by coincidence of skin neoplasm and visceral malignancies. Here, we report a case of this rare disease, whose diagnosis of the syndrome was first suspected by the pathologist. This was a 60-yr-old woman who presented with an axillary skin nodule, which was diagnosed as basal cell carcinoma. Read More

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http://dx.doi.org/10.1097/PGP.0000000000000572DOI Listing
December 2018
5 Reads

The illusion of conventional histological resection margin control.

Br J Dermatol 2018 Dec 4. Epub 2018 Dec 4.

Department of Dermatology, Maastricht University Medical Center+, Maastricht, The Netherlands.

An advantage of surgical treatment for basal cell carcinoma (BCC) over other therapeutic options is the possibility of histological margin control. The general understanding is that only 1-2% of the actual margins are checked histologically using the 'bread loaf' or step sectioning technique for conventional excision specimens, but the percentage of resection margins that are microscopically evaluated have not actually been quantified to date. [1, 2] This study's objective was to calculate the mean percentage of resection margins of BCC excision specimens that is histologically evaluated. Read More

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http://dx.doi.org/10.1111/bjd.17510DOI Listing
December 2018

Risk Factors for Fatal Pulmonary Hemorrhage following Concurrent Chemoradiotherapy in Stage 3B/C Squamous-Cell Lung Carcinoma Patients.

J Oncol 2018 1;2018:4518935. Epub 2018 Nov 1.

Bahcesehir University Medical Faculty, Department of Radiation Oncology, Istanbul, Turkey.

We aimed to identify the fatal pulmonary hemorrhage- (FPH-) related risk factors in stage 3B/C squamous-cell lung carcinoma (SqCLC) patients treated with definitive concurrent chemoradiotherapy (C-CRT). Medical records of 505 stage 3B/C SqCLC patients who underwent 66 Gy radiotherapy plus 1-3 cycles of concurrent chemotherapy with available pretreatment thoracic computerized tomography scans were retrospectively analyzed. Primary end-point was the identification of FPH-related risk factors. Read More

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http://dx.doi.org/10.1155/2018/4518935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236701PMC
November 2018

A New Technique for Reconstruction of Medium-Sized Eyelid Defects (A Modification of Tessier Nasojugal Flap).

Facial Plast Surg 2018 Dec 4. Epub 2018 Dec 4.

Department of Plastic and Reconstructive Surgery, Urmia University of Medical Sciences, Imam Khomeini Teaching Hospital, Urmia, West Azerbaijan, the Islamic Republic of Iran.

Eyelid reconstructions are considered challenging surgical procedures, which are mostly performed due to trauma, tumor resections, and congenital defects. Several techniques can be used to reconstruct the lower eyelid defects. In this study, the authors aimed to introduce a new single-step technique for the reconstruction of medium-sized lower eyelid defects while preventing ectropion. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1676050
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http://dx.doi.org/10.1055/s-0038-1676050DOI Listing
December 2018
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Diagnostic accuracy of ex vivo fluorescence confocal microscopy for Mohs surgery of basal cell carcinomas: a prospective study on 753 margins.

Br J Dermatol 2018 Dec 4. Epub 2018 Dec 4.

Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Pathology Unit, Reggio Emilia, Italy.

Background: Frozen histological sections are currently used for intra-operative margin assessment during Mohs surgery. Fluorescence confocal microscopy (FCM) is a new tool, which offers a promising and faster alternative to frozen histology.

Objective: The aim of the present study is to prospectively evaluate in a clinical setting, the accuracy of FCM as compared to frozen sections in BCC's margin assessment. Read More

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http://dx.doi.org/10.1111/bjd.17507DOI Listing
December 2018
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Variant subtype of xeroderma pigmentosum diagnosed in a 77-year-old woman.

JAAD Case Rep 2018 Nov 14;4(10):1074-1076. Epub 2018 Nov 14.

Division of Dermatology, Dell Medical School, University of Texas at Austin, Austin, Texas.

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http://dx.doi.org/10.1016/j.jdcr.2018.08.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250902PMC
November 2018
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An Unusual Case Report: Occurrence of Renal Cell Carcinoma, Basal Cell Carcinoma and Chronic Lymphocytic Leukemia in a Case of Papillary Thyroid Carcinoma Treated with Radioactive Iodine.

Iran J Med Sci 2018 Nov;43(6):659-663

Department of Hematology and Medical Oncology, Shiraz University of Medical Sciences, Shiraz, Iran.

The standard therapy for thyroid cancer is total or near total thyroidectomy, followed by the administration of radioactive iodine for remnant ablation or residual disease. Patients with radioiodine therapy are predisposed to second malignant neoplasms in organs such as central nervous system (CNS), breast, prostate, kidney, bone marrow, salivary gland, and digestive tract. Exposure to carcinogen including occupational and therapy related hazard, aging and genetic susceptibility are other causes of second primary cancers. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230934PMC
November 2018
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[Use of the autologous dorsal dermis in reconstruction of the posterior palpebral lamella in blepharopoiesis].

Ann Chir Plast Esthet 2018 Nov 30. Epub 2018 Nov 30.

Département de chirurgie plastique, reconstructrice, brûlés, plaies et cicatrisation, CHU Lapeyronie, 371, avenue de Doyen Gaston Giraud, 34295 Montpellier, France. Electronic address:

Objectives: Blepharopoiesis represents a double aesthetic and functional challenge. If anterior lamellar reconstruction is less discussed, the variety of posterior lamellar substitutes testifies that none is ideal. We report here our experience of the use of autologous dermal dermis as posterior lamellar substitutes in bilamellar blepharopoiesis. Read More

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http://dx.doi.org/10.1016/j.anplas.2018.07.006DOI Listing
November 2018
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Data Set for the Reporting of Ear and Temporal Bone Tumors: Explanations and Recommendations of the Guidelines From the International Collaboration on Cancer Reporting.

Arch Pathol Lab Med 2018 Nov 30. Epub 2018 Nov 30.

From the University of Sydney, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia (Dr Gupta); the Department of Head and Neck and Oral Pathology, Guy's Hospital, London, United Kingdom (Dr Sandison); the Department of Pathology, Moffitt Cancer Center, Tampa, Florida (Dr Wenig); and the Department of Pathology, Southern California Permanente Medical Group, Woodland Hills Medical Center, Woodland Hills (Dr Thompson).

The International Collaboration on Cancer Reporting (ICCR) was established to internationally unify and standardize the pathologic reporting of cancers based on collected evidence, as well as to allow systematic multi-institutional intercountry data collection to guide cancer care in the future. Such collaborative efforts are particularly essential for developing an evidence base for rare neoplasms, or those with marked geographic variation in incidence, such as the tumors of the ear and the temporal bone. The ear and the temporal bone, including the external auditory canal and the middle and inner ear, with the closely associated facial nerve, internal carotid artery, and internal jugular vein, is one of the most complex anatomic structures in the head and neck. Read More

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http://dx.doi.org/10.5858/arpa.2018-0415-SADOI Listing
November 2018