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    Cryosurgery + 5% 5-Fluorouracil for Treatment of Superficial Basal Cell Carcinoma and Bowen's Disease.
    J Cutan Med Surg 2018 Feb 1:1203475418758973. Epub 2018 Feb 1.
    2 Department of Medicine, Division of Dermatology, University of Alberta, Edmonton, AB, Canada.
    Background: Superficial basal cell carcinoma (sBCC) and squamous cell carcinoma in situ (SCCis) are 2 types of nonmelanoma skin cancers (NMSCs) that are amenable to treatment with topical 5-fluorouracil, cryosurgery, or topical imiquimod, among other destructive and surgical modalities. There are few studies examining the effectiveness of combination therapy with 5% 5-fluorouracil and cryosurgery for the treatment of sBCC and SCCis.

    Objectives: Our objective was to study the clinical cure rate achieved with the regimen of cryosurgery and a 3-week course of 5% 5-fluorouracil in the treatment of biopsy-proven sBCC and SCCis. Read More

    The E3 ubiquitin ligase NEDD4 mediates cell migration signaling of EGFR in lung cancer cells.
    Mol Cancer 2018 Feb 19;17(1):24. Epub 2018 Feb 19.
    School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, 212013, China.
    Background: EGFR-dependent cell migration plays an important role in lung cancer progression. Our previous study observed that the HECT E3 ubiquitin ligase NEDD4 is significantly correlated with tumor metastasis and required for migration and invasion signaling of EGFR in gastric cancer cells. However, how NEDD4 promotes the EGFR-dependent lung cancer cell migration is unknown. Read More

    Basal cell nevus syndrome (Gorlin syndrome): genetic insights, diagnostic challenges, and unmet milestones.
    Pathophysiology 2018 Jan 31. Epub 2018 Jan 31.
    Department of Oral and Maxillofacial/Head and Neck Surgery, Louisiana State University Health Sciences Center, Shreveport, LA, United States; Chancellor and Dean, Louisiana State University Health Sciences Center, Shreveport, LA, United States.
    In this article, we present three clinical case reports on Basal Cell Nevus Syndrome (Gorlin Syndrome). Gorlin syndrome is an inherited medical condition with challenges that manifest in multiple body systems and complicate early diagnosis. We examine the epidemiology of the disease and benefits of genetic testing, molecular pathophysiology, and advancement in the molecular-based therapy of Basal Cell Nevus syndrome. Read More

    A phase I and pharmacokinetic study of taladegib, a Smoothened inhibitor, in Japanese patients with advanced solid tumors.
    Invest New Drugs 2018 Feb 17. Epub 2018 Feb 17.
    Division of Thoracic Oncology, Shizuoka Cancer Center, Shizuoka, Japan.
    Background This phase I dose-escalation study investigated the safety of the Smoothened inhibitor taladegib in Japanese patients with advanced solid tumors. Methods Patients received taladegib orally once daily for 28-day cycles, using a 3 + 3 dose-escalation method. The primary objective was the safety and tolerability of taladegib at doses up to the global recommended dose (400 mg). Read More

    Basal Cell Carcinoma in Cases with or without Xeroderma Pigmentosum.
    JNMA J Nepal Med Assoc 2017 Oct-Dec;56(208):432-437
    Department of Pathology, Manipal College of Medical Science, Pokhara, Nepal.
    Introduction: Basal cell carcinoma is the most common form of cancer in humans and comprises the vast majority of skin cancers. It predominantly affects fair-skinned individuals, and its incidence is rapidly increasing. The objective of the study is to identify the epidemiology, its topography and different histological subtypes of basal cell carcinoma in patients with or without Xeroderma Pigmentosum. Read More

    Dermoscopic and reflectance confocal microscopy features of two cases of vulvar basal cell carcinoma.
    Dermatol Pract Concept 2018 Jan 31;8(1):68-71. Epub 2018 Jan 31.
    Department of Medical, Surgical and Neuro-Sciences, Dermatology Unit, University of Siena, Siena, Italy.
    Basal cell carcinoma (BCC) is the most common malignant skin cancer. Its genital localization is rare, and the diagnosis in this site could be challenging. Here, we report two patients with vulvar BCC and describe their clinical, dermoscopic and in vivo and ex vivo reflectance confocal microscopic (RCM) features. Read More

    Methods for multivariate recurrent event data with measurement error and informative censoring.
    Biometrics 2018 Feb 13. Epub 2018 Feb 13.
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, U.S.A.
    In multivariate recurrent event data regression, observation of recurrent events is usually terminated by other events that are associated with the recurrent event processes, resulting in informative censoring. Additionally, some covariates could be measured with errors. In some applications, an instrumental variable is observed in a subsample, namely a calibration sample, which can be applied for bias correction. Read More

    Ulcerated Basal Cell Carcinomas Masquerading as Venous Leg Ulcers.
    Adv Skin Wound Care 2018 Mar;31(3):130-134
    Catherine N. Tchanque-Fossuo, MD, MS, is a Clinical Wound Fellow, at both the Department of Dermatology, University of California Davis, Sacramento, and the Dermatology Service, VA Northern California Health Care Systems, Mather, California. Jillian W. Millsop, MD, MS, is a Dermatology Resident, Department of Dermatology, University of California Davis, Sacramento, California. Mary Ann Johnson, MD, MS, is a Dermatologist, Mercy Medical Group-Dignity Health, El Dorado Hills, California. Sara E. Dahle, DPM, MPH, is Chief, Podiatry Section, Department of Surgery, VA Northern California Health Care Systems, Mather, and Assistant Professor, Department of Dermatology, University of California Davis, Sacramento, California. R. Rivkah Isseroff, MD, is Chief, Dermatology Service, VA Northern California Health Care Systems, Mather, and Professor, Department of Dermatology, University of California Davis, Sacramento, California. The authors have disclosed they have no financial relationships related to this article. Submitted January 15, 2017; accepted in revised form October 27, 2017.
    Background: Nonmelanoma skin cancers rarely arise from venous leg ulcers (VLUs). Although basal cell carcinoma (BCC) is the most common nonmelanoma skin cancer, its association with lower-extremity ulcers is not as frequently reported as other malignancies.

    Objective: To report a case series of biopsy-proven BCC from lower-extremity ulcers of patients who presented at a multispecialty wound clinic. Read More

    Hepatotoxicity Associated With Vismodegib.
    BMJ Case Rep 2018 Feb 8;2018. Epub 2018 Feb 8.
    Department of Internal Medicine, Michigan State University, Lansing, Michigan, USA.
    An 82-year-old Caucasian woman with a history of basal cell carcinoma on vismodegib presented with nausea, vomiting and intermittent abdominal pain. Laboratory results were remarkable for the elevation of liver enzymes. Endoscopic retrograde cholangiopancreatography and percutaneous transhepatic cholangiogram (PTC) did not show evidence of intrahepatic or extrahepatic obstruction of the biliary tract. Read More

    An expanded study of long-pulsed 1064 nm Nd:YAG laser treatment of basal cell carcinoma.
    Lasers Surg Med 2018 Feb 13. Epub 2018 Feb 13.
    Dermatology Cosmetic and Laser Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, 02114.
    Background And Objective: Basal cell carcinoma (BCC) is an indolent form of skin cancer that is rarely life threatening, but can cause significant cosmetic and functional morbidity. Surgical treatments often result in disfiguring scars, while topical therapies frequently result in recurrence. The need for a more effective nonsurgical alternative has led to the investigation of laser treatment of BCC. Read More

    Malignant tumor of outer root sheath epithelium, trichilemmal carcinoma. Clinical presentations, treatments and outcomes.
    Saudi Med J 2018 Feb;39(2):213-216
    Department of Plastic Reconstructive and Aesthetic Surgery, Faculty of Medicine, Celal Bayar University, Manisa, Turkey. E-mail.
    Objectives: To emphasize different clinical features of tumor that can be misdiagnosed clinically.

    Methods: A total of 8 cases operated between September 2009 and 2016 at the Celal Bayar University, Faculty of Medicine were included in the study. Patients' clinicopathological features, type of surgery and follow up information were evaluated. Read More

    Association between inflammation and cancer stem cell phenotype in breast cancer.
    Oncol Lett 2018 Feb 13;15(2):2380-2386. Epub 2017 Dec 13.
    Department of Surgery, Raphael Hospital, Jung, Daegu 41968, Republic of Korea.
    Inflammation and cancer stem cells (CSCs) are becoming increasingly recognized as components of tumorigenesis in breast cancer. In the present study, the association between inflammation and BCSC phenotype was evaluated in human breast cancer tissue. Immunohistochemical staining for cluster of differentiation (CD)24, 44, 4, 8 and 68 was performed using tissue microarray blocks containing 47 consecutive cases of invasive breast carcinoma and 10 normal breast tissue samples. Read More

    Differential expression patterns of GATA3 in usual and differentiated types of vulvar intraepithelial neoplasia: potential diagnostic implications.
    Mod Pathol 2018 Feb 13. Epub 2018 Feb 13.
    Department of Pathology, Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, 9500 Euclid Avenue, L25, Cleveland, OH, 44195, USA.
    The two main precursors of vulvar squamous cell carcinoma, usual and differentiated vulvar intraepithelial neoplasia (VIN), have distinctive etiology, pathogenesis, and natural history. Usual type VIN is often associated with high-risk HPV and differentiated VIN has de novo p53 genetic alterations that are unrelated to HPV infection. GATA-binding protein 3 (GATA3) is a tumor suppressor that shows increased expression in several types of human malignancies including breast and bladder carcinomas. Read More

    A randomized, multi-national, non-inferiority, phase III trial to evaluate the safety and efficacy of BF-200 ALA gel versus MAL cream in the treatment of non-aggressive basal cell carcinoma with photodynamic therapy (PDT).
    Br J Dermatol 2018 Feb 12. Epub 2018 Feb 12.
    Department of Dermatology and Allergology, Vest Clinic, Recklinghausen, Germany.
    Background: Basal cell carcinoma (BCC) represents the most common non-melanoma skin cancer worldwide affecting mainly adult, fair-skinned individuals. The WHO distinguishes aggressive and non-aggressive forms of which prototypical variants of the latter are primary nodular and superficial BCC.

    Objectives: To demonstrate non-inferiority of BF-200 ALA (a nanoemulsion gel containing 5-aminolaevulinic acid) compared to MAL (a cream containing methyl-aminolevulinate) in the treatment of non-aggressive BCC with photodynamic therapy (PDT). Read More

    Classification of the clinical images for benign and malignant cutaneous tumors using a deep learning algorithm.
    J Invest Dermatol 2018 Feb 8. Epub 2018 Feb 8.
    Department of Dermatology, Asan Medical Center, Ulsan University College of Medicine, Seoul, Korea. Electronic address:
    We tested the use of a deep learning algorithm to classify the clinical images of 12 skin diseases-basal cell carcinoma, squamous cell carcinoma, intraepithelial carcinoma, actinic keratosis, seborrheic keratosis, malignant melanoma, melanocytic nevus, lentigo, pyogenic granuloma, hemangioma, dermatofibroma, and wart. The convolutional neural network (Microsoft ResNet-152 model) was fine-tuned with images from the training portion of the Asan dataset, MED-NODE dataset, and atlas site images (20,826 images in total). The trained model was validated with the testing portion of the Asan, Hallym and Edinburgh datasets. Read More

    The expression and function of galectins in skin physiology and pathology.
    Exp Dermatol 2018 Feb 10. Epub 2018 Feb 10.
    Institute of Biomedical Sciences, Academia Sinica, Taiwan.
    The galectin family comprises β-galactoside-binding proteins widely expressed in many organisms. There are at least 16 family members, which can be classified into three groups based on their carbohydrate-recognition domains. Pleiotropic functions of different galectins in physiological and pathological processes through extracellular or intracellular actions have been revealed. Read More

    Multiple roles of SIM2 in esophageal squamous cell carcinoma and its clinical implications.
    Cancer Sci 2018 Feb 10. Epub 2018 Feb 10.
    Department of Translational Oncology, National Cancer Center.
    The degree of histological differentiation is an important characteristic of cancers and may be associated with their malignant potentials. However, in squamous cell carcinomas, a key transcriptional factor to regulate tumor differentiation is largely unknown. Chemoradiotherapy (CRT) is a standard treatment for locally advanced esophageal squamous cell carcinoma (ESCC); however, the survival rate is still below 40%. Read More

    Novel Presentation of Fibroepithelioma of Pinkus on the Ear of a Patient Treated on a Panamanian Humanitarian Mission.
    Mil Med 2018 Feb 7. Epub 2018 Feb 7.
    Department of Dermatology, San Antonio Uniformed Services Health Education Consortium, 1100 Wilford Hall Loop Bldg 4554, JBSA, Lackland, TX 78236.
    Fibroepithelioma of Pinkus (FEP) is traditionally classified as an unusual variant of basal cell carcinoma. It has non-specific clinical findings yet distinct histologic features. The diagnosis can be challenging for clinicians because it often mimics benign entities such as intradermal nevi. Read More

    Alternative activation of hedgehog pathway induced by ultraviolet B radiation: preliminary study.
    Clin Exp Dermatol 2018 Feb 9. Epub 2018 Feb 9.
    Department of Dermatology and Pediatric and Oncologic Dermatology, Medical University of Łódź, Łódź, Poland.
    Background: There is still much ambiguity in studies of Sonic hedgehog (Shh) pathways and its dysregulation. Some studies concerning the role of the Shh pathway in basal cell carcinoma (BCC) have been conducted, but there is a lack of studies about Shh pathway dysregulation under the influence of ultraviolet (UV)B radiation.

    Aim: To evaluate skin expression of Shh, Ptch1, Ptch2, Smo and Gli1 proteins in BCCs with and without the influence of UVB radiation. Read More

    Analysis of hedgehog signaling in periocular sebaceous carcinoma.
    Graefes Arch Clin Exp Ophthalmol 2018 Feb 8. Epub 2018 Feb 8.
    Centre for Cell Biology and Cutaneous Research, Blizard Institute, Barts & London School of Medicine, 4 Newark St, London, E1 2AT, UK.
    Purpose: Sebaceous carcinoma (SC) is a clinical masquerader of benign conditions resulting in significant eye morbidity, sometimes leading to extensive surgical treatment including exenteration, and even mortality. Little is known about the genetic or molecular basis of SC. This study identifies the involvement of Hedgehog (Hh) signaling in periocular SC. Read More

    Erythrocyte Membrane Unsaturated (Mono and Poly) Fatty Acids Profile in Newly Diagnosed Basal Cell Carcinoma Patients.
    Clin Nutr Res 2018 Jan 24;7(1):21-30. Epub 2018 Jan 24.
    Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran 14155-6447, Iran.
    Studies have reported different changes in the fatty acid composition of red blood cell (RBC) total lipids in patients with various types of cancer. It has been indicated that n-3/n-6 ratio plays a key role in the general consequence of skin photocarcinogenesis. However, to our knowledge there was no study examining the unsaturated fatty acid profile in basal cell carcinoma (BCC) patients. Read More

    Complex functional and epithetic rehabilitation after ablation of recurrent retroauricular basal cell carcinoma - a case study.
    GMS Interdiscip Plast Reconstr Surg DGPW 2017 18;6:Doc18. Epub 2017 Dec 18.
    Department of Oral and Plastic Maxillofacial Surgery, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
    The reconstruction of extended defects of the concha poses a complex challenge for plastic surgeons. In cases of subtotal ablation, an alternative method designed especially for elderly oncological patients consists of epithetic rehabilitation. However, inserting an implant-retained concha epithesis proves challenging in patients with antecedents of deep resections involving the mastoid process. Read More

    Cutaneous Metastases from Salivary Duct Carcinoma of the Submandibular Gland.
    Case Rep Dermatol 2017 Sep-Dec;9(3):254-258. Epub 2017 Dec 5.
    Department of Plastic and Breast Surgery, Zealand University Hospital - Roskilde, Roskilde, Denmark.
    Salivary duct carcinoma is a rare and highly aggressive malignant neoplasm that frequently metastasises to other organs, but cutaneous metastasis is uncommon. There are only 6 cases reported in the literature with metastases to the skin and in all cases the tumour originates from the parotid gland. We present a case of skin metastases from the submandibular gland that was mistaken for basal cell carcinoma. Read More

    Incomplete excision of basal cell carcinoma (BCC) in the head and neck region: to wait, or not to wait?
    Postepy Dermatol Alergol 2017 Dec 31;34(6):607-611. Epub 2017 Dec 31.
    Department of Plastic Surgery, Medical Centre for Postgraduate Education, Professor W. Orlowski Memorial Hospital, Warsaw, Poland.
    Introduction: Recurrence rates for incompletely excised basal cell carcinoma (BCC) vary widely in the literature. Clinical observation is a commonly accepted method of follow up, however such management of these lesions still remains controversial.

    Aim: To evaluate the rate and factors associated with the recurrence of BCC of the head and neck region after incomplete excision. Read More

    Current applications of high-frequency ultrasonography in dermatology.
    Postepy Dermatol Alergol 2017 Dec 31;34(6):535-542. Epub 2017 Dec 31.
    Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland.
    The era of ultrasounds in dermatology started in 1979, when pioneering use of 15 MHz by Alexander and Miller in measuring the skin thickness was introduced. Since then, some new applications of high-frequency ultrasonography (HF-USG) have emerged providing the clinicians with an extra hand in their everyday practice. The main advantages of HF-USG include the possibility of real-time imaging, measurements of morphological and physiological aspects of the skin, safety associated with the use of non-ionizing media as well as the lack of contraindications to its performance. Read More

    Nonmelanoma skin cancer in Saudi Arabia: single center experience.
    Ann Saudi Med 2018 Jan-Feb;38(1):522-525
    Dr. Yousef Binamer, MBC 104 Department of Dermatology,, King Faisal Specialist Hospital and Research Centre,, PO Box 3354, Riyadh 11211, Saudi Arabia, T: 966-11-4424602, ORCID:
    Background: Skin cancer is the most common cancer worldwide; one in every three diagnosed malignancies is a skin cancer. However, skin cancer is rarely reported in Saudi Arabia so we conducted this study to highlight these underreported neoplasms.

    Objectives: Determine the prevalence and patterns of basal cell carcinoma (BCC) and primary squamous cell carcinoma (SCC), the most common types of nonmelanoma skin cancer (NMSC) with respect to age, sex, and anatomic location and to identify potentially associated risk factors. Read More

    Transcriptome evolution from breast epithelial cells to basal-like tumors.
    Oncotarget 2018 Jan 8;9(1):453-463. Epub 2017 Dec 8.
    Translational Research Unit and CIBERONC, Albacete University Hospital, Albacete, Spain.
    In breast cancer, it is unclear the functional modifications at a transcriptomic level that are associated with the evolution from epithelial cells and ductal carcinoma(DCIS) to basal-like tumors. By applying weighted gene co-expression network analysis (WGCNA), we identified 17 gene co-expression modules in normal, DCIS and basal-like tumor samples. We then correlated the expression pattern of these gene modules with disease progression from normal to basal-like tumours and found eight modules exhibiting a high and statistically significant correlation. Read More

    Photodynamic Therapy Activated by Intense Pulsed Light in the Treatment of Nonmelanoma Skin Cancer.
    Biomedicines 2018 Feb 7;6(1). Epub 2018 Feb 7.
    Skin Center, Dermo-Aesthetic Lasers Centers, 67051 Avezzano, Italy.
    Photodynamic therapy (PDT) with topical 5-aminolevulinic acid (ALA) or methyl aminolevulinate (MAL) has proven to be a highly effective conservative method for the treatment of actinic keratosis (AK), Bowen's disease (BD), and superficial basal cell carcinoma (sBCC). PDT is traditionally performed in association with broad-spectrum continuous-wave light sources, such as red or blue light. Recently, intense pulsed light (IPL) devices have been investigated as an alternative light source for PDT in the treatment of nonmelanoma skin cancers (NMSC). Read More

    Auricular Acupuncture and Skin-Cancer Detection: An Opportunity.
    Med Acupunct 2018 Feb;30(1):39-40
    Department of Medicine, Yale University School of Medicine, and VA Connecticut Healthcare System, West Haven, CT.
    Auricular acupuncture is effective for many patients with pain. Many skin malignancies and precancerous lesions are found on the head and neck. Practitioners of acupuncture are in a unique situation to detect cutaneous malignancy at an early state. Read More

    Structure-Activity Relationship Studies of Vitamin D3 Analogues Containing an Ether or Thioether Linker as Hedgehog Pathway Inhibitors.
    ChemMedChem 2018 Feb 6. Epub 2018 Feb 6.
    University of Connecticut, Pharmaceutical Sciences, 69 N Eagleville Rd, Unit 3092, 06269, Storrs, UNITED STATES.
    The Hedgehog (Hh) signaling pathway is critical for embryonic patterning and postembryonic tissue regeneration. Constitutive pathway activation has also been linked to human malignancies such as basal cell carcinoma (BCC) and medulloblastoma; therefore, multiple small molecule scaffolds that inhibit Hh signaling are in development. Previously, Grundmann's alcohol, also known as the "northern region" of vitamin D3 (VD3), has been identified as a moderate Hh pathway inhibitor. Read More

    Emerging trends in the treatment of advanced basal cell carcinoma.
    Cancer Treat Rev 2017 Dec 14;64:1-10. Epub 2017 Dec 14.
    Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
    Basal cell carcinoma (BCC) is the most commonly diagnosed skin cancer worldwide. In most patients, BCC can be effectively treated with standard surgical excision, Mohs micrographic surgery, curettage and electrodessication, radiotherapy, and/or superficial field therapies (including 5-fluorouracil, imiquimod, and photodynamic therapy); however, a minority of patients develop advanced BCC, for which treatment can be challenging and outcomes are poorer. Advanced BCC encompasses a heterogeneous assortment of cases, including metastatic BCC as well as locally advanced BCC (for which no formal definition exists but which generally includes large, deep, aggressive, or recurrent tumors). Read More

    Senior Commentary to "Long-Term Follow-Up Results of Topical Imiquimod Treatment in Basal Cell Carcinoma".
    Dermatol Surg 2018 Feb 5. Epub 2018 Feb 5.
    Department of Dermatology, Maastricht University Medical Centre, Maastricht, the Netherlands GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, the Netherlands.

    Levocarnitine for vismodegib-associated muscle spasms: a pilot randomized, double-blind, placebo-controlled, investigator initiated trial.
    J Eur Acad Dermatol Venereol 2018 Feb 6. Epub 2018 Feb 6.
    Department of Dermatology, Stanford University School of Medicine, Redwood City, California, USA.
    Smoothened inhibitors (SIs) are a new, targeted therapy for the treatment of advanced basal cell carcinoma (BCC), but their usage is significantly limited by the most common side effect, muscle spasms. Muscle spasms affect up to 80% of users, and are the most common reason for drug discontinuation despite tumor response. Currently, no placebo-controlled trials exist to guide the management of vismodegib-related muscle spasms. Read More

    Application of in vivo reflectance confocal microscopy (RCM) and ex vivo fluorescence confocal microscopy (FCM) in most common subtypes of Basal Cell Carcinoma and correlation with histopathology.
    Br J Dermatol 2018 Feb 6. Epub 2018 Feb 6.
    Dermatology Department at Melanoma Unit, Hospital Clínic & IDIBAPS, University of Barcelona, Barcelona, Spain.
    Basal cell carcinoma (BCC) accounts for 80% of non-melanoma skin cancer. The identification of the histological subtype is crucial for the correct management of the tumor. In vivo reflectance confocal microscopy (RCM) is a novel technique that has demonstrated high sensitivity and specificity in the in vivo diagnosis of BCC. Read More

    Characteristics of Familial Melanoma in Valencia, Spain, Based on the Presence of CDKN2A Mutations and MC1R Variants.
    Acta Derm Venereol 2018 Feb 6. Epub 2018 Feb 6.
    Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, Spain.
    Melanoma results from a complex interplay between environmental factors and individual genetic susceptibility. Familial melanoma is attributable to predisposition genes with variable penetrance. The aim of this study was to identify differences between familial melanoma and sporadic cases in our population, based on the presence of CDKN2A mutations and MC1R variants. Read More

    The best of the best: a review of select oculoplastic case series published in 2015.
    Digit J Ophthalmol 2017 21;23(4):1-3. Epub 2017 Nov 21.
    Department of Ophthalmology, SUNY Downstate Medical Center, Brooklyn, New York.
    This review summarizes three case series published in the field of oculoplastic surgery in the year 2015. The first article describes the use of hedgehog pathway inhibitors for medical therapy of advanced periocular basal cell carcinoma and basal cell nevus syndrome. The second describes the use of c-reactive protein as a marker for starting treatment with steroids in children with orbital cellulitis. Read More

    Fine Needle Aspiration Cytology of Basal Cell Adenoma of Parotid Simulating Adenoid Cystic Carcinoma.
    J Cytol 2018 Jan-Mar;35(1):55-57
    Department of Pathology, Kolkata National Medical College, Kolkata, West Bengal, India.
    Basal cell adenoma is a rare type of monomorphic salivary adenoma most commonly involving the parotid gland. Cytology of basal cell adenoma closely mimics many other benign and malignant basaloid neoplasms. Cytological features of membranous basal cell adenoma simulate adenoid cystic carcinoma in fine needle aspiration cytology (FNAC) smears. Read More

    The value of ultrasound diagnosis in the multidisciplinary approach of cutaneous tumours. Case report.
    Med Ultrason 2018 Feb;1(1):108-110
    Department of Cranio-Maxillofacial Surgery and Radiology, Faculty of Dentistry, University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca, Romania..
    We report the case of a senior patient, presenting with two cutaneous tumours in which the clinical and dermoscopic examination pointed towards a basal cell carcinoma. Ultrasound revealed highly vascularised tumours and elastography showed increased rigidity. Histological examination of both lesions following complete resection was consistent with squamous cell carcinomas. Read More

    Genomic landscape of advanced basal cell carcinoma: Implications for precision treatment with targeted and immune therapies.
    Oncoimmunology 2018 22;7(3):e1404217. Epub 2017 Dec 22.
    Department of Medicine, Division of Hematology/Oncology, University of California San Diego, La Jolla, CA, USA.
    Metastatic basal cell cancer (BCC) is an ultra-rare malignancy with no approved therapies beyond Hedgehog inhibitors. We characterized the genomics, tumor mutational burden (TMB), and anti-PD-1 therapy responses in patients with locally advanced or metastatic BCC. Overall, 2,039 diverse cancer samples that had undergone comprehensive genomic profiling (CGP) were reviewed. Read More

    Custom mold applicator high-dose-rate brachytherapy for nonmelanoma skin cancer-An analysis of 273 lesions.
    Brachytherapy 2018 Feb 1. Epub 2018 Feb 1.
    Department of Radiation Oncology, Baylor Scott & White Health, Temple, TX; Department of Radiation Oncology, University of Arizona College of Medicine Phoenix, Tucson, AZ.
    Purpose: Nonmelanoma skin cancer is the most commonly diagnosed malignancy in the United States. A modern version of surface brachytherapy, "topographic applicator brachytherapy" (TAB), can be used to treat early-stage nonmelanoma skin cancer (ES-NMSC). The purpose of this study was to evaluate the acute toxicity, chronic toxicity, and recurrence rates of patients with ES-NMSC treated with TAB. Read More

    Ionizing Radiation deregulates the microRNA expression profile in differentiated thyroid cells.
    Thyroid 2018 Feb 3. Epub 2018 Feb 3.
    Universita degli studi di Napoli Federico II, Dipartimento di biologia e patologia cellulare e moleculare Istituto di endocrinologia ed oncologia sperimentale del CNR , VIA PANSINI 5 , Naples, Italy , 80131 ;
    Background: Ionizing Radiation (IR) is a well-known risk factor for papillary thyroid cancer, and it has been reported to deregulate microRNA expression, which is important to thyroid carcinogenesis. Therefore, we have investigated the impact of IR on microRNA expression profile of the normal thyroid cell line (FRTL-5 CL2) and as well as its effect on radiosensitivity of thyroid cancer cell lines, especially the human anaplastic thyroid carcinoma cell line (8505c).

    Methods: The global microRNA expression profile of irradiated FRTL-5 CL2 cells (5 Gy X-ray) was characterized and data were confirmed by qRT-PCR evaluating the expression of rno-miR-10b-5p, rno-miR-33-5p, rno-miR-128-1-5p, rno-miR-199a-3p, rno-miR-296-5p, rno-miR-328a-3p and rno-miR-541-5p in irradiated cells. Read More

    Arsenic promotes the COX2/PGE2-SOX2 axis to increase the malignant stemness properties of urothelial cells.
    Int J Cancer 2018 Feb 2. Epub 2018 Feb 2.
    Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
    Chronic arsenic exposure is associated with the development of urothelial carcinoma of the bladder (UCB). To elucidate the contribution of arsenic exposure to urothelial cancer stem cell (CSC) generation, we established an in vitro stepwise malignant model transformed by chronically exposing human urothelial cells to arsenic. Using this model, we found that chronic arsenic exposure endows urothelial cells with malignant stemness properties including increased expression of stemness-related factors such as SOX2, sphere formation, self-renewal, invasion and chemoresistance. Read More

    Effect of the normal mammary differentiation regulator ELF5 upon clinical outcomes of triple negative breast cancers patients.
    Breast Cancer 2018 Feb 2. Epub 2018 Feb 2.
    Department of Anatomical Pathology, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aobaku, Sendai, 980-8575, Japan.
    Background: Elf5 is a transcription factor previously shown to be involved in regulating cell differentiation in both normal and pathological breast tissues. Pertinently, Elf5 was reported to interact with the FOXA1 transcription factor, a pivotal regulatory factor in a subset of AR overexpressing triple negative cancer (TNBC) cases.

    Methods: We examined the correlation among AR, FOXA1, and Elf5 expression in a series of TNBC cases. Read More

    Targeted inhibition of Hedgehog-GLI signaling by novel acylguanidine derivatives inhibits melanoma cell growth by inducing replication stress and mitotic catastrophe.
    Cell Death Dis 2018 Feb 2;9(2):142. Epub 2018 Feb 2.
    Core Research Laboratory, Istituto Toscano Tumori, Florence, Italy.
    Aberrant activation of the Hedgehog (HH) signaling is a critical driver in tumorigenesis. The Smoothened (SMO) receptor is one of the major upstream transducers of the HH pathway and a target for the development of anticancer agents. The SMO inhibitor Vismodegib (GDC-0449/Erivedge) has been approved for treatment of basal cell carcinoma. Read More

    Tumor Architecture and Notch Signaling Modulate Drug Response in Basal Cell Carcinoma.
    Cancer Cell 2018 Feb 27;33(2):229-243.e4. Epub 2018 Jan 27.
    Departments of Dermatology, and Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:
    Hedgehog (Hh) pathway inhibitors such as vismodegib are highly effective for treating basal cell carcinoma (BCC); however, residual tumor cells frequently persist and regenerate the primary tumor upon drug discontinuation. Here, we show that BCCs are organized into two molecularly and functionally distinct compartments. Whereas interior Hh/Notchsuprabasal cells undergo apoptosis in response to vismodegib, peripheral Hh/Notchbasal cells survive throughout treatment. Read More

    Comparing Topical Treatments for Basal Cell Carcinoma.
    J Invest Dermatol 2018 Jan 29. Epub 2018 Jan 29.
    Department of Dermatology, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA; Center for Dermatoepidemiology, Veterans Affairs Medical Center, Providence, Rhode Island, USA; Department of Epidemiology, Brown University, School of Public Health, Providence, Rhode Island, USA. Electronic address:
    Superficial basal cell carcinoma is a type of keratinocyte carcinoma that has increasing incidence and substantial morbidity. Jansen et al. report on a randomized trial with 5 years of follow-up that found imiquimod to be more effective than 5-fluorouracil or methyl aminolevulinate photodynamic therapy in preventing superficial basal cell carcinoma recurrence. Read More

    Defect Reconstruction of the Nose After Surgery for Nonmelanoma Skin Cancer: Our Clinical Experience.
    Turk Arch Otorhinolaryngol 2017 Sep 1;55(3):111-118. Epub 2017 Sep 1.
    Department of Otorhinolaryngology, Ege University School of Medicine, İzmir, Turkey.
    Objective: This study aimed to investigate reconstruction methods according to nasal subunits in patients who were surgically treated with diagnosis of non-melanoma skin cancer of the nose.

    Methods: All patients were retrospectively investigated. This study was conducted between April 2004 and December 2010; 180 patients who were surgically treated with diagnoses of skin basal cell carcinoma, squamous cell carcinoma, cancer of skin appendages, and precancerous lesions and 194 lesions were included. Read More

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