30,175 results match your criteria Epitheliomas Basal Cell


Non-HPV-related verrucous carcinoma of the endometrium: report of one case and review of literature.

Int J Clin Exp Pathol 2020 1;13(6):1444-1450. Epub 2020 Jun 1.

Department of Medicine, Yantai Yuhuangding Hospital of Qingdao University Yantai, Shandong, P. R. China.

The clinicopathologic diagnosis and treatment of a case of endometrial verrucous carcinoma were analyzed, combined with the relevant literature for review and discussion. The patient was a 67-year-old postmenopausal woman who had recurrent vaginal bleeding with increased secretion. The gross morphology and histopathology of the uterine cavity tumor had typical characteristic changes of verrucous carcinoma. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344013PMC

An easy and cheap surgical pocket case for draining blood when performing scalp surgery.

J Am Acad Dermatol 2020 Jul 10. Epub 2020 Jul 10.

Department of Dermatology, University of Bologna, Bologna, Italy.

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http://dx.doi.org/10.1016/j.jaad.2019.04.071DOI Listing

Photodynamic therapy in Dermatology: beyond current indications.

Dermatol Ther 2020 Jul 11. Epub 2020 Jul 11.

Serviço de Dermatologia, Hospital de Santa Maria, Centro Hospitalar e Universitário de Lisboa Norte, Lisboa, Portugal.

Photodynamic therapy (PDT) has long been used in Dermatology as a therapeutic strategy for several malignant and premalignant conditions. Currently, it is approved in Europe for the treatment of actinic keratosis, squamous cell carcinoma in situ and some forms of basal cell carcinoma, with favorable clearance rates associated with satisfying aesthetic results. Nonetheless, in the past few years PDT has also demonstrated efficacy in many other conditions, including inflammatory and infectious dermatoses. Read More

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http://dx.doi.org/10.1111/dth.13997DOI Listing

Basal cell carcinoma with perineural invasion: a prospective study examining subtype, tumor surface diameter, invasion depth and anatomic site in 3,005 consecutive cases.

J Cutan Pathol 2020 Jul 12. Epub 2020 Jul 12.

The University of New South Wales, Sydney, Australia.

Background: Basal cell carcinoma (BCC) may present with or without perineural invasion (PNI). We reviewed BCC for PNI by subtype, microscopic tumor surface diameter, invasion depth and anatomic site.

Method: Consecutive excisions were prospectively collected in an Australian center 2016-18. Read More

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http://dx.doi.org/10.1111/cup.13808DOI Listing

Morphological Analysis of Blood Capillaries and Transport Function of Endothelial Cells in Hepatocellular Carcinoma-29.

Bull Exp Biol Med 2020 Jul 10. Epub 2020 Jul 10.

Research Institute of Clinical and Experimental Lymphology - Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia.

Hepatocellular carcinoma is characterized by the pronounced vascularization, high levels of vascular endothelial growth factors, and intensive angiogenesis. Caveola-mediated endocytosis and clathrin-dependent endocytosis contribute to internalization of various growth factors, thus affecting blood supply to the tumor and neoangiogenesis. We performed a quantitative analysis of blood vessels in the tumor and evaluated the basal levels of endocytosis-associated vesicular structures in the endothelial cells of the hepatocellular carcinoma-29. Read More

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http://dx.doi.org/10.1007/s10517-020-04867-wDOI Listing

Desmoplastic Melanoma as a Diagnostic Pitfall.

Acta Dermatovenerol Croat 2020 Jul;28(1):49-50

Dear Editor, Desmoplastic melanoma (DM) is a rare histological subtype of melanoma, usually presenting as a slowly-growing, amelanotic, discoid, and/or firm lesion composed of spindle cells with abundant collagen (1). It is more common on sun-exposed areas, especially on head and neck in elderly patients (2). Regional lymph node involvement is reported to be less frequent than in other cutaneous melanomas (3). Read More

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Expression of p16 Protein in Cutaneous Basal Cell Carcinoma: Still far from Being Clearly Understood.

Authors:
Vladimir Bartoš

Acta Dermatovenerol Croat 2020 Jul;28(1):43-44

Vladimir Bartoš, MD, Faculty Hospital, Žilina, Slovakia;

Dear Editor, p16INK4a protein (p16) is an important tumor suppressor protein involved in the carcinogenesis of many human malignancies. I have read with interest an article by Donati et al. (1) in this journal, who investigated an expression of p16 and proliferation marker Ki-67 in cutaneous tumors. Read More

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Topical Imiquimod for Management of Recurrent Lentigo Maligna Melanoma in Situ.

Acta Dermatovenerol Croat 2020 Jul;28(1):34-37

Professor Igor Bartenjev, MD, PhD, Department of Dermatovenerology, Medical faculty, University of Ljubljana, Pod kostanji 4, 1000 Ljubljana, Slovenia;

Topical imiquimod is a medication approved for the treatment of external genital and perianal warts, actinic keratosis, and superficial basal cell carcinoma. There have also been reports of its successful use in patients with lentigo maligna melanoma in situ. An 80-year-old female patient was diagnosed with lentigo maligna melanoma in situ which was then surgically removed. Read More

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Metabolic signature of eyelid basal cell carcinoma.

Exp Eye Res 2020 Jul 7:108140. Epub 2020 Jul 7.

Department of Ophthalmology, West Virginia University, Morgantown, WV, 26506, USA; Department of Biochemistry, West Virginia University, Morgantown, WV, 26506, USA. Electronic address:

Purpose: Eyelid basal cell carcinoma (BCC) is the most common eyelid malignancy. Metabolic reprogramming is critical in tumorigenesis, but the metabolic feature of eyelid BCC remains elusive. In this study, we aim to reveal the metabolic profile in eyelid BCC using targeted metabolomics. Read More

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http://dx.doi.org/10.1016/j.exer.2020.108140DOI Listing

Malignant wounds: Basal cell carcinoma presenting as a nonhealing ulceration on an arteriovenous fistula.

J Vasc Access 2020 Jul 10:1129729820940183. Epub 2020 Jul 10.

Hospital Universitario de León, León, Spain.

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http://dx.doi.org/10.1177/1129729820940183DOI Listing

A Human Liver-on-a-Chip Platform for Modeling Nonalcoholic Fatty Liver Disease.

Adv Biosyst 2019 Aug 14;3(8):e1900104. Epub 2019 Jun 14.

Department of Bioengineering, Henry Samueli School of Engineering and Applied Sciences, University of California-Los Angeles, Los Angeles, CA, 90095, USA.

The liver possesses a unique microenvironment with a complex internal vascular system and cell-cell interactions. Nonalcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease, and although much effort has been dedicated to building models to target NAFLD, most in vitro systems rely on simple models failing to recapitulate complex liver functions. Here, an in vitro system is presented to study NAFLD (steatosis) by coculturing human hepatocellular carcinoma (HepG2) cells and umbilical vein endothelial cells (HUVECs) into spheroids. Read More

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http://dx.doi.org/10.1002/adbi.201900104DOI Listing

Personalized irradiation therapy for NMSC by rhenium-188 skin cancer therapy: a long-term retrospective study.

J Dermatolog Treat 2020 Jul 10:1-17. Epub 2020 Jul 10.

Department of Dermatology and Allergy Biederstein, School of Medicine, Technical University of Munich, Munich, Germany.

This study aimed to provide long-term clinical data about an innovative epidermal radioisotope therapy called Rhenium-SCT® (Skin Cancer Therapy) for non-melanoma skin cancer (NMSC), based on the use of the non-sealed beta emitter rhenium-188. 52 NMSC patients with a mean age of 71.7 years were treated with rhenium-188 skin cancer therapy between the years 2005 and 2014. Read More

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http://dx.doi.org/10.1080/09546634.2020.1793890DOI Listing

Association of bullous pemphigoid and comorbid health conditions: a case-control study.

Arch Dermatol Res 2020 Jul 10. Epub 2020 Jul 10.

Department of Dermatology, Northwestern University Feinberg School of Medicine, Suite 1600, 676 N Saint Clair Street, Chicago, IL, 60611, USA.

Background: Bullous pemphigoid is an autoimmune skin disease characterized by the formation of blisters between the epidermis and dermis. Comorbidities of pemphigoid have not been well-described. Identification of comorbidities associated with pemphigoid is important to decrease morbidity and mortality. Read More

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http://dx.doi.org/10.1007/s00403-020-02100-2DOI Listing

Evaluation of the Use of Capecitabine for the Treatment and Prevention of Actinic Keratoses, Squamous Cell Carcinoma, and Basal Cell Carcinoma: A Systematic Review.

JAMA Dermatol 2020 Jul 8. Epub 2020 Jul 8.

Department of Dermatology, University of Texas Southwestern Medical Center, Dallas.

Importance: Certain patient groups, such as solid organ transplant recipients (SOTRs), have a significantly increased risk of developing skin cancers. The chemotherapeutic drug capecitabine has been used off label as a chemopreventive modality to suppress the development of precancerous skin lesions and squamous cell carcinomas (SCCs).

Objective: To systematically review published studies on the use of capecitabine for the treatment and prevention of precancerous and cancerous skin lesions, with a focus on cutaneous SCC. Read More

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http://dx.doi.org/10.1001/jamadermatol.2020.2327DOI Listing

Linear closure of surgical defects on the nose after intraoperative tissue relaxation as an alternative to a skin flap or graft.

JAAD Case Rep 2020 Jul 23;6(7):679-682. Epub 2020 May 23.

Department of Dermatologic Surgery, Good Samaritan Regional Medical Center/Silver Falls Dermatology, Salem, Oregon.

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http://dx.doi.org/10.1016/j.jdcr.2020.05.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327306PMC

Epidemiology of cutaneous sebaceous carcinoma.

Australas J Dermatol 2020 Jul 6. Epub 2020 Jul 6.

South Australian Institute of Ophthalmology, Royal Adelaide Hospital, The University of Adelaide, Adelaide, Australia.

There has been uncertainty about the demographics and anatomical distribution of cutaneous sebaceous carcinoma. This study aims to investigate these uncertainties by analysing data from various countries. Data were obtained from cancer registries of the United States, England, Norway and Taiwan, and incidence rates were calculated with uniform age-adjustment. Read More

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http://dx.doi.org/10.1111/ajd.13387DOI Listing

A systems biology-driven approach to construct a comprehensive protein interaction network of influenza A virus with its host.

BMC Infect Dis 2020 Jul 6;20(1):480. Epub 2020 Jul 6.

Faculty of Environmental and Life Sciences, Beijing University of Technology, Beijing, 100124, China.

Background: Influenza A virus (IAV) infection is a serious public health problem not only in South East Asia but also in European and African countries. Scientists are using network biology to dig deep into the essential host factors responsible for regulation of virus infections. Researchers can explore the virus invasion into the host cells by studying the virus-host relationship based on their protein-protein interaction network. Read More

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http://dx.doi.org/10.1186/s12879-020-05214-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339526PMC

Basal cell carcinoma misdiagnosed as trichoepithelioma.

Arch Craniofac Surg 2020 Jun 29;21(3):202-205. Epub 2020 Jun 29.

Department of Plastic and Reconstructive Surgery, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.

Trichoepithelioma is a benign hair follicle tumor that can undergo malignant transformation into basal cell carcinoma in rare cases. Due to the similar clinical and histological features of trichoepithelioma and basal cell carcinoma, distinguishing between these types of tumors can be a diagnostic challenge. Punch biopsy obtains only a small sample of the entire lesion, and thus inherently involves a risk of misdiagnosis between histologically similar diseases. Read More

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http://dx.doi.org/10.7181/acfs.2020.00157DOI Listing

Multiple nonmelanocytic skin cancers in multiple regions.

Arch Craniofac Surg 2020 Jun 29;21(3):188-192. Epub 2020 Jun 29.

Department of Plastic and Reconstructive Surgery, Konkuk University Chungju Hospital, Konkuk University School of Medicine, Chungju, Korea.

The most common forms of nonmelanocytic skin cancer (NMSC) are basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The growing incidence of skin cancer in the Republic of Korea has sparked increasing scientific interest in these types of tumors. In the case described herein, multiple NMSCs occurred asynchronously in various areas of the body in a single patient. Read More

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http://dx.doi.org/10.7181/acfs.2020.00073DOI Listing

Biopsy Outperforms Reflectance Confocal Microscopy in Diagnosing and Subtyping Basal Cell Carcinoma: Results and Experiences from a Randomized Controlled Multicentre Trial.

Br J Dermatol 2020 Jul 6. Epub 2020 Jul 6.

Department of Dermatology, Radboud University Medical Centre, Nijmegen, The Netherlands.

Background: Reflectance confocal microscopy (RCM) is a non-invasive method for skin assessment, allowing entire lesion evaluation up to the papillary dermis. Therefore, RCM is a potentially attractive alternative to punch biopsy in basal cell carcinoma (BCC).

Objectives And Design: This randomized controlled trial aimed to investigate RCM as alternative to punch biopsy in a real-world clinical setting. Read More

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http://dx.doi.org/10.1111/bjd.19381DOI Listing

Boosting the Synthesis of Pharmaceutically Active Abietane Diterpenes in Hairy Roots by Engineering the and Genes.

Front Plant Sci 2020 18;11:924. Epub 2020 Jun 18.

Department of Pharmacy, University of Salerno, Fisciano, Italy.

Abietane diterpenoids (ADs), synthesized in the roots of different species, such as aethiopinone, 1-oxoaethiopinone, salvipisone, and ferruginol, have a variety of known biological activities. We have shown that aethiopinone has promising cytotoxic activity against several human tumor cell lines, including the breast adenocarcinoma MCF7, HeLa, epithelial carcinoma, prostate adenocarcinoma PC3, and human melanoma A375. The low content of these compounds in natural sources, and the limited possibility to synthesize them chemically at low cost, prompted us to optimize the production of abietane diterpenoids by targeting genes of the methylerythritol phosphate (MEP) pathway, from which they are derived. Read More

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http://dx.doi.org/10.3389/fpls.2020.00924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315395PMC

Amelanotic melanoma in a patient with oculocutaneous albinism.

Dermatol Online J 2020 May 15;26(5). Epub 2020 May 15.

Department of Dermatology, Hospital Clinico Universitario de Valladolid, Valladolid.

Oculocutaneous albinism is a genetically heterogeneous, autosomal recessive group of disorders characterized by a generalized decreased or absence of melanin pigment in the eyes, hair, and skin. These patients have a greater sensitivity to UV radiation and a predisposition to skin tumors, mainly squamous cell carcinoma and basal cell carcinomas, and to a lesser extent malignant melanomas. Melanoma can be one of the most challenging cancers to diagnose in patients with albinism. Read More

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Basal cell carcinoma associated with erythema ab igne.

Dermatol Online J 2020 Apr 15;26(4). Epub 2020 Apr 15.

Department of Dermatology, Razi Hospital, Tehran University of Medical Science, Tehran.

Erythema ab igne is a skin condition mainly caused by heat exposure. Erythema ab igne usually follows a favorable prognosis. However, it may increase the risk of developing cutaneous malignancy in the involved skin. Read More

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Unusual presentation of Kaposi sarcoma in an HIV-negative woman.

Dermatol Online J 2020 Apr 15;26(4). Epub 2020 Apr 15.

The University of Texas MD Anderson Cancer Center, Houston, TX.

Kaposi sarcoma typically presents as violaceous macules and papules in immunocompromised, specifically HIV-positive, patients. Its distinct clinical features often facilitate rapid diagnosis. In this article, we report a case of Kaposi sarcoma presenting as a concerning yet nondescript lesion in an HIV-negative woman. Read More

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Maxillofacial rehabilitation of nasal defect with nasal prosthesis using donor method: A case report.

Niger J Clin Pract 2020 Jul;23(7):1022-1025

Department of Dental Diagnostic Science and Oral Biology, King Khalid University, Abha, Saudi Arabia.

Maxillofacial prosthetics is the branch of prosthodontics which involves rehabilitation of the defects in the maxillofacial region involving the hard and soft tissue with the prosthesis. Facial defects that occur in the midfacial regions are commonly due to trauma and neoplasms like basal cell carcinoma which involves the nose. Reconstruction of the nose is an important esthetic challenge due to its esthetic and retention problems. Read More

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http://dx.doi.org/10.4103/njcp.njcp_657_19DOI Listing

Skin Architecture, Kidney Transplantation, and Their Relationship to Basal and Squamous Cell Carcinomas.

Anticancer Res 2020 Jul;40(7):4017-4022

Department of Translational Medical Sciences, University of Campania "L. Vanvitelli", Naples, Italy

Background/aim: Squamous cell carcinoma (SCC) is highly prevalent in kidney transplant patients (KT). It is characterized by the presence of an inflammatory infiltrate. In this study, we examined the presence of similar infiltrates in intact skin, which could be regarded as a precancerous step. Read More

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http://dx.doi.org/10.21873/anticanres.14396DOI Listing

Basal Cell Carcinoma and Eccrine Porocarcinoma of the Eyelid.

Ophthalmic Plast Reconstr Surg 2020 Jun 17. Epub 2020 Jun 17.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida.

An 81-year-old woman presented with a progressively enlarging indurated, firm lesion encompassing one-third of the left upper eyelid. Four years prior, a similar lesion at that same site had been excised and diagnosed as a basal cell carcinoma. The patient underwent a full-thickness excision of the lesion with frozen section, cryotherapy, and reconstruction. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001743DOI Listing

Trends in pediatric skin cancer.

Curr Opin Pediatr 2020 Jun 30. Epub 2020 Jun 30.

Harvard Medical School, Boston, Massachusetts, USA.

Purpose Of Review: To inform pediatric providers of the clinical characteristics, underlying genetic drivers, and therapeutic options for skin cancer arising in childhood and adolescence.

Recent Findings: The incidence of melanoma in pediatric patients has been declining in the past decades. Pediatric-specific diagnostic criteria should be utilized when assessing lesions concerning for melanoma to better account for the different presentations seen in pediatric disease compared with adults, such as an increased prevalence of amelanotic melanoma or frequent mimic of benign pediatric lesions. Read More

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http://dx.doi.org/10.1097/MOP.0000000000000917DOI Listing

Metastatic Basal Cell Carcinoma of the Skin: A Comprehensive Literature Review, Including Advances in Molecular Therapeutics.

Adv Anat Pathol 2020 Jul 1. Epub 2020 Jul 1.

Department of Pathology, The Barzilai Medical Center, Ashkelon, Israel.

Basal cell carcinoma (BCC) of the skin is the most common type of malignant human tumor. In Europe, the incidence of BCC ranges from 44.6 to 128 cases per 100,000 inhabitants annually, whereas in the United States, the yearly incidence rate ranges between 500 and 1500. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000267DOI Listing

Eyelid skin trichilemmoma and underlying local malignancy: is an aggressive treatment necessary?

BMJ Open Ophthalmol 2020 25;5(1):e000513. Epub 2020 Jun 25.

Department of Ophthalmology, Royal Hallamshire Hospital, Sheffield, UK.

Objective: Trichilemmoma is a benign tumour derived from the outer root sheath of hair follicles. Trichilemmoma can be associated with basal cell carcinoma (BCC), either as a collision lesion or from malignant transformation. This study evaluates malignancy associated with eyelid trichilemmoma and principles of treatment. Read More

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http://dx.doi.org/10.1136/bmjophth-2020-000513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319780PMC

REPLY to MS#JAAD-D-20-02240: Effective Therapy for Advanced Basal Cell Carcinoma.

J Am Acad Dermatol 2020 Jun 29. Epub 2020 Jun 29.

Department of Medicine, Division of Hematology/Oncology, University of California San Diego, La Jolla, CA; Center of Personalized Cancer Therapy, University of California San Diego, La Jolla, CA.

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http://dx.doi.org/10.1016/j.jaad.2020.06.988DOI Listing

Polygenic risk scores allow risk stratification for keratinocyte cancer in organ transplant recipients.

J Invest Dermatol 2020 Jun 29. Epub 2020 Jun 29.

Statistical Genetics Lab, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston QLD 4006, Australia; School of Biomedical Sciences, Faculty of Health, and Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove QLD 4059, Australia.

Organ transplant recipients (OTRs) have an elevated risk for keratinocyte cancers (KC); basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). We assessed whether polygenic risk scores (PRSs) generated in non-transplantees from the UK Biobank and 23andMe (13,981 SCC, 33,736 BCC, and >560,000 controls), can predict KC risk in an independent OTR cohort. After adjusting for traditional risk factors, compared to the bottom 20%, OTRs in the top 20% PRS had an increased risk of BCC (OR = 3. Read More

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http://dx.doi.org/10.1016/j.jid.2020.06.017DOI Listing
June 2020
7.216 Impact Factor

Epidermal activation of Hedgehog signaling establishes an immunosuppressive microenvironment in basal cell carcinoma by modulating skin immunity.

Mol Oncol 2020 Jul 2. Epub 2020 Jul 2.

Department of Biosciences, Cancer Cluster Salzburg, Paris-Lodron University Salzburg, Salzburg, Austria.

Genetic activation of Hedgehog (HH)/GLI signaling causes basal cell carcinoma (BCC), a very frequent non-melanoma skin cancer. Small molecule targeting of the essential HH effector Smoothened (SMO) has proven an effective therapy of BCC, though the frequent development of drug resistance poses major challenges to anti-HH treatments. In light of recent breakthroughs in cancer immunotherapy, we analyzed the possible immunosuppressive mechanisms in HH/GLI-induced BCC in detail. Read More

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http://dx.doi.org/10.1002/1878-0261.12758DOI Listing

Periorbital, conjunctival and primary intraorbital carcinomas: Survival and risk factors after orbital exenteration.

Eye (Lond) 2020 Jul 1. Epub 2020 Jul 1.

Department of Oral and Maxillofacial Surgery, University of Duisburg-Essen, Kliniken-Essen-Mitte, Henricistr. 92, 45136, Essen, Germany.

Objectives: This study aimed to analyse the disease-free survival (DFS), overall survival (OS) and risk factors after orbital exenteration in patients with periorbital, conjunctival and primary intraorbital carcinomas.

Methods: Patients undergoing orbital exenteration due to a primary carcinoma between March 2000 and March 2018 were included in this retrospective study. Risk factors in all the patients were evaluated using univariate and multivariate analyses. Read More

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http://dx.doi.org/10.1038/s41433-020-1055-1DOI Listing

Ectopic Cushing syndrome in Colombia.

Arch Endocrinol Metab 2020 Jun 29. Epub 2020 Jun 29.

Departamento de Neoplasia Endocrina y Trastornos Hormonales, Universidad de Texas, MD Anderson Cancer Center, Houston Texas.

Objective: The aim was to describe the clinical features of patients with ectopic Cushing syndrome (ECS) from Colombia and compare these findings with other series to provide the best management for these patients.

Materials And Methods: Records of patients with ECS from 1986 to 2017 were retrospectively reviewed; patients with a diagnosis of adrenal or pituitary Cushing syndrome (CS) were excluded.

Results: Fourteen patients with ECS were analyzed in this study. Read More

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http://dx.doi.org/10.20945/2359-3997000000271DOI Listing

Classification of Skin Lesions into Seven Classes Using Transfer Learning with AlexNet.

J Digit Imaging 2020 Jun 30. Epub 2020 Jun 30.

Department of Electronics and Communication, Faculty of Engineering, Zagazig University, Zagazig 44519, Egypt.

Melanoma is deadly skin cancer. There is a high similarity between different kinds of skin lesions, which lead to incorrect classification. Accurate classification of a skin lesion in its early stages saves human life. Read More

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http://dx.doi.org/10.1007/s10278-020-00371-9DOI Listing

Reply Letter to the Editor Regarding: Basal cell carcinoma: Management of advanced or metastatic cancer with checkpoint inhibitors and concurrent paradoxical development of new superficial tumors.

J Am Acad Dermatol 2020 Jun 27. Epub 2020 Jun 27.

Dr. Phillip Frost Department of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.

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http://dx.doi.org/10.1016/j.jaad.2020.06.987DOI Listing

Melanoma and non-melanoma skin cancer among patients who attended at King Khalid University Hospital in Riyadh, Saudi Arabia from 2007 - 2018.

Saudi Med J 2020 Jul;41(7):709-714

Division of Plastic Surgery, College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia. E-mail.

Objectives: To assess the prevalence of melanoma and non-melanoma skin cancer for patients attended King Khalid University Hospital, Riyadh, Saudi Arabia. We are also assessing the most common category of skin cancer to be encountered among those patients. Methods: The authors conducted a retrospective study including all patients (Saudi and non-Saudi) who attended King Khalid University Hospital (KKUH) at the period of (2007-2018). Read More

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http://dx.doi.org/10.15537/smj.2020.7.25138DOI Listing

Periocular skin cancer: Diagnosis and management.

Dis Mon 2020 Jun 26:101046. Epub 2020 Jun 26.

Division of Ophthalmology, NorthShore University Health System, 2050 Pfingsten Rd., Ste. 280, Glenview, IL 60026, United States; Department of Ophthalmology and Visual Science, University of Chicago, Chicago, IL, United States. Electronic address:

The periocular region sees high rates of cancer compared to the rest of the body and can be affected by several unique tumors. Treatment typically involves surgical excision, although adjunctive therapies and prognosis vary depending on the diagnosis. Basal cell carcinoma (BCC) is the most common malignancy affecting this region and should be excised promptly. Read More

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http://dx.doi.org/10.1016/j.disamonth.2020.101046DOI Listing

Trichoblastomas Mimicking Basal Cell Carcinoma: The Importance of Identification and Differentiation.

Cureus 2020 May 25;12(5):e8272. Epub 2020 May 25.

Dermatology, State University of New York Downstate Medical Center, Brooklyn, USA.

Trichoblastoma is a rare, slow-growing, benign cutaneous tumor derived from follicular germinative cells. Trichoblastoma commonly appears as an asymptomatic, symmetrical, well-circumscribed, skin-colored to brown or blue-black papule or nodule. It may appear clinically and histologically similar to basal cell carcinoma, making its diagnosis challenging. Read More

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http://dx.doi.org/10.7759/cureus.8272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314372PMC

Therapeutic Implications of Immunohistochemical Expression Pattern of the Cancer Stem Cell Marker (Nestin) in Basal and Squamous Cell Carcinomas.

Dermatol Ther 2020 Jun 28:e13921. Epub 2020 Jun 28.

Department of Dermatology, National Research Centre.

Cancer stem cells (CSC) are populations of cells responsible for tumor initiation, progression and therapeutic resistance in many cancers. In the present study, we aimed to investigate the expression pattern and clinical significance of the stem cell marker nestin, in Squaous cell carcinoma (SCC) and basal cell carcinoma (BCC). The samples (23 cases of BCC and 22 cases of SCC) were immunohistochemically examined for the expression of nestin and its correlation with the corresponding clinical and pathological parameters. Read More

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http://dx.doi.org/10.1111/dth.13921DOI Listing

Dermatoses of the world: Burden of skin disease and associated socioeconomic status in the world.

J Am Acad Dermatol 2020 Jun 25. Epub 2020 Jun 25.

Apex Dermatology and Skin Surgery Center, Mayfield Heights, OH; Lake Erie College of Osteopathic Medicine, Erie, PA.

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http://dx.doi.org/10.1016/j.jaad.2020.05.157DOI Listing

Association between circulating FSTL-1 and metabolic syndrome in middle-aged and old population: a cross-sectional study.

Diabetes Metab Res Rev 2020 Jun 27:e3373. Epub 2020 Jun 27.

Department of Endocrinology, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.

Aim: Follistatin-like-1 (FSTL-1) is considered to be a novel cytokine, and it is associated with metabolic diseases. However, it is necessary to investigate further the association of FSTL-1 with metabolic syndrome (MetS) and insulin resistance (IR). We performed a cross-sectional study to investigate the associated of circulating FSTL-1 with the MetS. Read More

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http://dx.doi.org/10.1002/dmrr.3373DOI Listing

A Deep Learning Algorithm to Detect the Presence of Basal Cell Carcinoma on Mohs Micrographic Surgery Frozen Sections.

J Am Acad Dermatol 2020 Jun 23. Epub 2020 Jun 23.

University of California San Diego, Department of Dermatology.

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http://dx.doi.org/10.1016/j.jaad.2020.06.080DOI Listing

Absence of BRAFV600E Immunohistochemical Expression in Sporadic Odontogenic Keratocyst, Syndromic Odontogenic Keratocyst and Orthokeratinized Odontogenic Cyst.

J Oral Pathol Med 2020 Jun 26. Epub 2020 Jun 26.

Department of Oral Pathology and Microbiology, Nair Hospital Dental College, Mumbai, 400008, India.

Background: Odontogenic keratocyst (OKC) is a unique developmental odontogenic cyst that has the potential to behave aggressively, and is associated with the nevoid basal cell carcinoma syndrome. Orthokeratinized odontogenic cyst (OOC) is a distinct, uncommon odontogenic cyst. It significantly differs from OKC not only in its epithelial lining but also in proliferating kinetics, clinical, immunohistochemical and biological behaviour. Read More

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http://dx.doi.org/10.1111/jop.13081DOI Listing

The 2019 Genitourinary Pathology Society (GUPS) White Paper on Contemporary Grading of Prostate Cancer.

Arch Pathol Lab Med 2020 Jun 26. Epub 2020 Jun 26.

From the Departments of Pathology (Drs Epstein, DeMarzo, and Lotan), Urology (Dr Epstein), and Oncology (Dr Epstein), The Johns Hopkins Medical Institutions, Baltimore, Maryland; Department of Pathology and Laboratory Medicine and Urology, University of Tennessee Health Science, Memphis (Dr Amin); Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York (Dr Fine); Department of Pathology, Fundacio Puigvert, Barcelona, Spain (Dr Algaba); Department of Pathology, University of Southern California, Los Angeles (Dr Aron); Department of Pathology, Faculty of Medicine, Koç University, İstanbul, Turkey (Dr Baydar); Department of Pathology, Champalimaud Centre for the Unknown, Lisbon, Portugal (Dr Beltran); Department of Pathology, McGill University Health Center, Montréal, QC, Canada (Dr Brimo); Department of Pathology, Mayo Clinic, Rochester, Minnesota (Drs Cheville and Jimenez); Department of Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy (Dr Colecchia); Department of Pathology, Hôpital Tenon, Sorbonne University, Paris, France (Dr Comperat); Pathology Department, Rede D'OR-Sao Luiz, Sao Paulo, SP, Brazil (Dr da Cunha); Douglass Hanly Moir Pathology, Sydney, Australia (Dr Delprado); Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee (Drs Giannico and Gordetsky); Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston (Dr Guo); Department of Pathology, Oregon Health and Science University, Portland (Dr Hansel); Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (Dr Hirsch); Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California (Dr Huang); Department of Pathology, Yale School of Medicine, New Haven, Connecticut (Dr Humphrey); Department of Pathology and Laboratory Medicine and Urology, Weill Cornell Medicine, New York, New York (Drs Khani and Robinson); Department of Pathology, Qingdao Municipal Hospital, Qingdao, Shandong, China (Dr Kong); Departments of Pathology and Laboratory Medicine and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida (Dr Kryvenko); Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan (Drs Kunju and Mehra); Perelman School of Medicine, University of Pennsylvania, Philadelphia (Dr Lal); Department of Pathology, CHUM, Université de Montréal, Montréal, QC, Canada (Dr Latour); Douglass Hanly Moir Pathology, Faculty of Medicine and Health Sciences Macquarie University, North Ryde, Australia (Dr Maclean); Department of Pathology, The University of Alabama at Birmingham, Birmingham (Drs Magi-Galluzzi and Netto); Department of Surgical Pathology, Tata Memorial Hospital, Parel, Mumbai, India (Dr Menon); Departments of Pathology and Laboratory Medicine and Urology, University of Rochester Medical Center, Rochester, New York (Dr Miyamoto); Section of Pathological Anatomy, School of Medicine, Polytechnic University of the Marche Region, United Hospitals, Ancona, Italy (Dr Montironi); Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio (Dr Nguyen); Department of Pathology, Emory University School of Medicine, Atlanta, Georgia (Dr Osunkoya); Department of Pathology, Ohio State University, Columbus (Drs Parwani and Zynger); Department for BioMedical Research, University of Bern, Bern, Switzerland (Dr Rubin); Department of Pathology, The University of Texas Southwestern Medical Center, Dallas (Dr Shah); Institute of Pathology, St Luke's Medical Center, Quezon City and Global City, Philippines (Dr So); Department of Pathology, The Jikei University School of Medicine, Tokyo, Japan (Dr Takahashi); Argos Laboratory, Federal University of Ceara, Fortaleza, Brazil (Dr Tavora); Department of Pathology, University of Washington School of Medicine, Seattle (Drs Tretiakova and True); Departments of Pathology and Laboratory Medicine and Urology, University of North Carolina, Chapel Hill (Dr Wobker); Department of Pathology, Northwestern University, Chicago, Illinois (Dr Yang); Department of Pathology, Tufts Medical Center, Boston, Massachusetts (Dr Zhou); and Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB, Canada (Dr Trpkov). Dr Kong is currently located at Kaiser Permanente Sacramento Medical Center, Sacramento, California.

Context.—: Controversies and uncertainty persist in prostate cancer grading.

Objective. Read More

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http://dx.doi.org/10.5858/arpa.2020-0015-RADOI Listing
June 2020
2.838 Impact Factor

Eyelid basal cell carcinoma with neuroendocrine differentiation: a case report and literature review.

Orbit 2020 Jun 25:1-4. Epub 2020 Jun 25.

Department of Ophthalmology, Western Health , Melbourne, Australia.

Basal cell carcinoma (BCC) is the most common type of malignant tumor in the periocular region. BCCs with neuroendocrine differentiation in the periocular region, however, have not been described in the literature. We present a retrospective case review of a patient with an eyelid BCC with neuroendocrine differentiation. Read More

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http://dx.doi.org/10.1080/01676830.2020.1778738DOI Listing