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    Airway Basal Cell Heterogeneity and Lung Squamous Cell Carcinoma.
    Cancer Prev Res (Phila) 2017 Aug 18. Epub 2017 Aug 18.
    Lungs for Living Research Centre, UCL Respiratory, University College London, London, United Kingdom.
    Basal cells are stem/progenitor cells that maintain airway homeostasis, enact repair following epithelial injury, and are a candidate cell-of-origin for lung squamous cell carcinoma. Heterogeneity of basal cells is recognized in terms of gene expression and differentiation capacity. In this Issue, Pagano and colleagues isolate a subset of immortalized basal cells that are characterized by high motility, suggesting that they might also be heterogeneous in their biophysical properties. Read More

    Positive regulatory interactions between YAP and Hedgehog signalling in skin homeostasis and BCC development in mouse skin in vivo.
    PLoS One 2017 18;12(8):e0183178. Epub 2017 Aug 18.
    School of Medical Sciences, UNSW Sydney, New South Wales, Sydney, Australia.
    Skin is a highly plastic tissue that undergoes tissue turnover throughout life, but also in response to injury. YAP and Hedgehog signalling play a central role in the control of epidermal stem/progenitor cells in the skin during embryonic development, in postnatal tissue homeostasis and in skin carcinogenesis. However, the genetic contexts in which they act to control tissue homeostasis remain mostly unresolved. Read More

    Dental, dermatological and radiographic findings in a case of Gorlin-Goltz Syndrome: report and review.
    Pan Afr Med J 2017 7;27:96. Epub 2017 Jun 7.
    Department of Prosthodontics School of Dental Sciences, KIMSDU, Karad, Maharashtra, India.
    Gorlin-Goltz syndrome (GGS) is a rare autosomal dominant disorder. The disease shows multiple organ involvement with variable clinical presentation. Thus a multidisciplinary approach is required for its prompt clinical diagnosis and management of this condition. Read More

    Ceruminous Adenoid Cystic Carcinoma of External Auditory Canal.
    J Int Adv Otol 2017 Aug;13(2):292-294
    Department of Otolaryngology, University of Kentucky, Lexington, Kentucky, USA.
    An adenoid cystic carcinoma (AdCC) of the ceruminous glands is very rare; its diagnosis is most often challenging, and simple biopsies may be misleading. Our paper describes a case of a circumferential mass of the left ear canal that was initially reported as a basal cell carcinoma on biopsies in the clinic and on frozen sections intraoperatively. The final pathology was an AdCC of the ceruminous glands of the external auditory canal. Read More

    Case-control study of chronic low-level exposure of inorganic arsenic species and non-melanoma skin cancer.
    J Dermatol 2017 Aug 16. Epub 2017 Aug 16.
    Department of Dermatology, College of Medicine, Dong-A University, Busan, Korea.
    A significant relationship between arsenic exposure and non-melanoma skin cancer (NMSC) is well known. The toxicity of arsenics which develop NMSC is dependent on their species. Accordingly, total arsenic levels are unreliable for risk assessment of NMSC. Read More

    Incidence of cancer among licenced commercial pilots flying North Atlantic routes.
    Environ Health 2017 Aug 16;16(1):86. Epub 2017 Aug 16.
    Department of Preventive Medicine, Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
    Background: To evaluate cancer incidence among licenced commercial pilots in association with cosmic radiation.

    Methods: Cohort study where ionizing radiation dose of cosmic radiation was estimated from airline data and software program and cancer incidence was obtained by record linkage with nation-wide cancer registry. All licenced commercial male airline pilots were followed from 1955 to 2015, ever or never employed at airline with international routes. Read More

    Modulation of breast cancer development in MMTV-PyVT mice by adiponectin: A perspective on tumor microenvironment.
    • Authors:
    J Clin Oncol 2015 Oct;33(28_suppl):34
    34 Background: The survival and growth of epithelial carcinoma cells are critically dependent on the interactions with the neighboring stromal cells. Adiponectin, a molecule exclusively produced by adipose tissue, possesses potent anti-inflammatory and anti-tumorigenic activities. Its expression and production are inversely associated with breast cancer risks in pre- and post-menopausal women. Read More

    Drug resistance induced by paclitaxel and carboplatin plasmatic concentrations in lung cancer cell lines.
    J Clin Oncol 2012 Oct;30(30_suppl):97
    Department of Human Anatomy and Embryology, School of Medicine, University of Granada, Granada, Spain.
    97 Background: Multidrug resistance (MDR) phenotype is the major cause of chemotherapy failure. It has been related to several proteins expression: P-glycoprotein (PgP), MRP family, LRP, and BCRP. We study the resistance pattern induced after paclitaxel and carboplatin in non-small cell lung cancer (NSCLC). Read More

    Management of basal cell carcinoma in the United States: Can we simplify care and reduce cost?
    J Clin Oncol 2014 Oct;32(30_suppl):17
    Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, NY.
    17 Background: Basal cell carcinoma (BCC) is the most common cancer in the US, affecting more than 3 million people every year, and the incidence of BCC is increasing. Traditional management of BCC involves multiple physician visits and a pre-treatment biopsy which may be unnecessary. We assessed the costs of treating BCC, comparing traditional management with a simplified scheme. Read More

    Nanoscale proteomic profiling to define diagnostic signatures and biomarkers of therapeutic activity in patients with RCC.
    J Clin Oncol 2013 Feb;31(6_suppl):432
    Stanford University School of Medicine, Stanford, CA.
    432 Background: Novel agents that inhibit kinases in the hypoxia and MTOR pathways can achieve response rates of 30-60% in renal cell carcinoma (RCC); however, protein biomarkers to diagnose RCC and guide treatment have not been identified.

    Methods: We developed the use of two high-throughput, nanoscale immunoassays to profile hypoxia and downstream signaling in clinical specimens from patients with RCC. These automated technologies minimize errors due to manual variability, and make 96 independent measurements per overnight experiment. Read More

    Presentation and pathology of breast cancer in patients with HIV.
    J Clin Oncol 2013 Sep;31(26_suppl):39
    University of Maryland Medical Center, Institute of Human Virology, Baltimore, MD.
    39 Background: With the use of highly active antiretroviral therapy, it is postulated the prevalence of breast cancer will increase in the HIV infected population. Few studies have evaluated the presentation and pathological features of breast cancer in this population.

    Methods: Charts of approximately 5,000 HIV patients seen between 2000-2011 at the University of Maryland were reviewed to identify those diagnosed with breast cancer. Read More

    LC3A Silencing Hinders Aggresome Vimentin Cage Clearance in Primary Choroid Plexus Carcinoma.
    Sci Rep 2017 Aug 14;7(1):8022. Epub 2017 Aug 14.
    Tumor Biology Research Program, Basic Research Unit, Department of Research, Children's Cancer Hospital Egypt 57357, P.O Box 11441, 1 Seket Al-Emam Street, Cairo, Egypt.
    Aggresomes are transient microtubule-dependent inclusion bodies that sequester misfolded proteins and are ultimately removed by autophagy. Here we report the generation of a choroid plexus carcinoma cell line; Children's Cancer Hospital Egypt (CCHE)-45, which is characterized by the constitutive formation of aggresomes. When examining the autophagy pathway as the main route for aggresomes clearance, CCHE-45 cells displayed increased autophagy flux mediated by MAP1LC3B. Read More

    Modeling and validating three dimensional human normal cervix and cervical cancer tissues in vitro.
    J Biomed Res 2017 Jan;31(3):240-247
    Department of Natural sciences, Middlesex University, The Burroughs, Hendon, London NW4 4BT, UK.
    The use of three dimensional in vitro systems in cancer research is a promising path for developing effective anticancer therapies. The aim of this study was to engineer a functional 3-Din vitro model of normal and cancerous cervical tissue.Normal epithelial and immortalized cervical epithelial carcinoma cell lines were used to construct 3-D artificial normal cervical and cervical cancerous tissues. Read More

    Characterization of Surgical Procedures in the Spanish Mohs Surgery Registry (REGESMOHS) for 2013-2015.
    Actas Dermosifiliogr 2017 Aug 9. Epub 2017 Aug 9.
    Unidad de Investigación, Fundación Piel Sana, Academia Española de Dermatología, Madrid, España.
    Introduction: The Spanish Mohs Surgery Registry is used to collect data on the use and outcomes of Mohs micrographic surgery (MMS) in Spain. The aim of this study was to describe perioperative and intraoperative data recorded for MMS procedures performed between July 2013 (when the registry started) and January 2016.

    Material And Methods: Prospective cohort study of data from 18 hospitals. Read More

    Cell Polarity Reversal Distinguishes True Micropapillary Growth From Retraction Artifact in Invasive Urothelial Carcinoma.
    Appl Immunohistochem Mol Morphol 2017 Aug 9. Epub 2017 Aug 9.
    *Department of Pathology and Laboratory Medicine, Rhode Island Hospital †Department of Pathology and Laboratory Medicine, Alpert Medical School of Brown University ‡Department of Pathology, Women and Infants Hospital of Rhode Island, Providence, RI §Department of Pathology, Johns Hopkins University, Baltimore, MD.
    Focal micropapillary features in invasive urothelial carcinoma is sometimes difficult to distinguish from retraction artifact morphologically. Cell polarity reversal has been demonstrated in micropapillary tumors by epithelial membrane antigen (EMA) immunostaining. We have previously described the use of E-cadherin as a cell polarity marker in ovarian micropapillary serous borderline tumors. Read More

    Anticancer drugs and the regulation of Hedgehog genes GLI1 and PTCH1, a comparative study in nonmelanoma skin cancer cell lines.
    Anticancer Drugs 2017 Aug 9. Epub 2017 Aug 9.
    aDepartment of Dermatology, Bispebjerg Hospital bDepartment of Oncology, Center for Experimental Drug and Gene Electrotransfer, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
    Nonmelanoma skin cancer is the most common cancer in humans, comprising mainly basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). BCC proliferation is highly dependent on the Hedgehog signaling pathway. We aimed to investigate a panel of anticancer drugs with known activity against skin cancer for their therapeutic potential in localized, enhanced topical treatment of SCC and BCC. Read More

    Endometriosis and the risk of skin cancer: a prospective cohort study.
    Cancer Causes Control 2017 Aug 10. Epub 2017 Aug 10.
    CESP, Fac. de médecine - Univ. Paris-Sud, Fac. de médecine - UVSQ, INSERM, Université Paris-Saclay, 94805, Villejuif Cedex, France.
    Purpose: Endometriosis has been associated with an increased risk of skin melanoma. However, associations with other skin cancer types and how they compare with melanoma are unclear. Our objective was to prospectively investigate the relationships between endometriosis and risk of non-melanoma and melanoma skin cancers. Read More

    Outcome following radiotherapy for head and neck basal cell carcinoma with 'aggressive' features.
    Oral Oncol 2017 Sep 27;72:157-164. Epub 2017 Jul 27.
    Department of Radiation Oncology, Princess Margaret Cancer Centre / University of Toronto, Toronto, Ontario, Canada. Electronic address:
    Objectives: The literature demonstrates that 'aggressive' head-and-neck basal cell carcinomas (HN-BCC) have a higher than expected relapse rate with unfavorable outcomes. We report outcomes following definitive (dRT) or post-operative radiotherapy (PORT) for these tumors.

    Methods: We reviewed all HN-BCC patients with 'aggressive' features (primary lesions diameter >10mm, >2 recurrences, or extra-cutaneous extension), treated with megavoltage dRT or PORT between 1998 and 2013. Read More

    Epithelial-to-mesenchymal transition contributes to invasion in squamous cell carcinomas originated from actinic keratosis through the differentiated pathway whereas proliferation plays a more significant role in the classical pathway.
    J Eur Acad Dermatol Venereol 2017 Aug 10. Epub 2017 Aug 10.
    Universitat Autònoma de Barcelona.
    Background: Every actinic keratosis (AK) starts with atypia at the basal layers of the epidermis (AK I). Progression into invasive squamous cell carcinoma (iSCC) may occur following two main pathways, classical and differentiated. In the former, iSCC only occurs after involvement of the upper epidermal layers by atypical cells (AK III), while in the latter iSCC develops directly from AK I. Read More

    Actinic keratoses show variable histological basal growth patterns - a proposed classification adjustment.
    J Eur Acad Dermatol Venereol 2017 Aug 10. Epub 2017 Aug 10.
    CentroDerm Clinic, Heinz-Fangman-Straße 57, Wuppertal, Germany.
    Background: Common histological classification schemes of actinic keratoses (AK) do not evaluate growth patterns at basal epidermal aspects of AK. Until now, the importance of basal epidermal growth patterns of AK has not been studied.

    Objective: To investigate the extent of atypical keratinocytes throughout the epidermis and variation in basal growth patterns of AK. Read More

    PLAG1 immunohistochemistry is a sensitive marker for Pleomorphic Adenoma: a comparative study with PLAG1 genetic abnormalities.
    Histopathology 2017 Aug 10. Epub 2017 Aug 10.
    Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
    Aims: PLAG1 gene rearrangement is the most common genetic abnormality in pleomorphic adenoma (PA), resulting in overexpression of PLAG1 protein. PA and carcinoma ex pleomorphic adenoma (CA ex-PA) can mimic various benign and malignant salivary gland tumors. The aims of this study are to evaluate the sensitivity and specificity of PLAG1 immunohistochemistry (IHC) in the differential diagnosis of PA and CA ex-PA and to compare the PLAG1 immunohistochemical results to PLAG1 gene abnormalities as detected by fluorescence in situ hybridization (FISH). Read More

    Identification of the SOX2 interactome by BioID reveals EP300 as a mediator of SOX2-dependent squamous differentiation and lung squamous cell carcinoma growth.
    Mol Cell Proteomics 2017 Aug 9. Epub 2017 Aug 9.
    Princess Margaret Cancer Centre, Canada
    Lung cancer is the leading cause of cancer mortality worldwide, with squamous cell carcinoma (SQCC) being the second most common form. SQCCs are thought to originate in bronchial basal cells through an injury response to smoking, which results in this stem cell population committing to hyperplastic squamous rather than mucinous and ciliated fates. Copy number gains in SOX2 in the region of 3q26-28 occur in 94% of SQCCs, and appear to act both early and late in disease progression by stabilizing the initial squamous injury response in stem cells and promoting growth of invasive carcinoma. Read More

    Notch Shapes the Innate Immunophenotype in Breast Cancer.
    Cancer Discov 2017 Aug 8. Epub 2017 Aug 8.
    Department of Surgical Oncology, Princess Margaret Cancer Centre, University Health Network
    Notch activation, which is associated with basal-like breast cancer (BLBC), normally directs tissue patterning, suggesting that it may shape the tumor microenvironment (TME). Here we show that Notch in tumor cells regulates the expression of two powerful pro-inflammatory cytokines, IL1β and CCL2, and the recruitment of tumor-associated macrophages (TAMs). Notch also regulates TGFβ-mediated activation of tumor cells by TAMs, closing a Notch-dependent paracrine signaling loop between these two cell types. Read More

    Commentary on: "Comprehensive transcriptional analysis of early-stage urothelial carcinoma." Hedegaard J, Lamy P, Nordentoft I, Algaba F, Høyer S, Ulhøi BP, Vang S, Reinert T, Hermann GG, Mogensen K, Thomsen MB, Nielsen MM, Marquez M, Segersten U, Aine M, Höglund M, Birkenkamp-Demtröder K, Fristrup N, Borre M, Hartmann A, Stöhr R, Wach S, Keck B, Seitz AK, Nawroth R, Maurer T, Tulic C, Simic T, Junker K, Horstmann M, Harving N, Petersen AC, Calle ML, Steyerberg EW, Beukers W, van Kessel KE, Jensen JB, Pedersen JS, Malmström PU, Malats N, Real FX, Zwarthoff EC, Ørntoft TF, Dyrskjøt L. Cancer Cell. 2016 Jul 11;30(1):27-42.
    Urol Oncol 2017 Aug 5. Epub 2017 Aug 5.
    Non-muscle-invasive bladder cancer (NMIBC) is a heterogeneous disease with widely different outcomes. We performed a comprehensive transcriptional analysis of 460 early-stage urothelial carcinomas and showed that NMIBC can be subgrouped into 3 major classes with basal- and luminal-like characteristics and different clinical outcomes. Large differences in biological processes such as the cell cycle, epithelial-mesenchymal transition, and differentiation were observed. Read More

    Repurposing itraconazole as an anticancer agent.
    Oncol Lett 2017 Aug 7;14(2):1240-1246. Epub 2017 Jun 7.
    Department of Medical Oncology, Meiwa Hospital, Nishinomiya, Hyogo 663-8186, Japan.
    Itraconazole, a common anti-fungal agent, has demonstrated potential anticancer activity, including reversing chemoresistance mediated by P-glycoprotein, modulating the signal transduction pathways of Hedgehog, mechanistic target of rapamycin and Wnt/β-catenin in cancer cells, inhibiting angiogenesis and lymphangiogenesis, and possibly interfering with cancer-stromal cell interactions. Clinical trials have suggested the clinical benefits of itraconazole monotherapy for prostate cancer and basal cell carcinoma, as well as the survival advantage of combination chemotherapy for relapsed non-small cell lung, ovarian, triple negative breast, pancreatic and biliary tract cancer. As drug repurposing is cost-effective and timesaving, a review was conducted of preclinical and clinical data focusing on the anticancer activity of itraconazole, and discusses the future directions for repurposing itraconazole as an anticancer agent. Read More

    Appearance of New Cutaneous Superficial Basal Cell Carcinomas during Successful Nivolumab Treatment of Refractory Metastatic Disease: Implications for Immunotherapy in Early Versus Late Disease.
    Int J Mol Sci 2017 Jul 31;18(8). Epub 2017 Jul 31.
    Department of Medicine, Division of Hematology/Oncology, University of California San Diego, La Jolla, CA 92093, USA.
    Metastatic basal cell carcinoma may be treated with hedgehog pathway inhibitors, including vismodegib and sonidegib. However, patients can demonstrate resistance to these agents. We describe a man with metastatic basal cell carcinoma who did not respond well to vismodegib and sonidegib. Read More

    Cutaneous transcriptome analysis in NIH hairless mice.
    PLoS One 2017 7;12(8):e0182463. Epub 2017 Aug 7.
    Department of Laboratory Animals, College of Animal Sciences, Jilin University, Changchun, Jilin, China.
    Mice with spontaneous coat mutations are ideal animal models for studying skin development and tumorigenesis. In this study, skin hair growth cycle abnormalities were examined in NIH hairless mice 42 days after birth (P42) by using hematoxylin-eosin (H&E) staining. To examine the gene expression patterns in the skin of mutant mice, the dorsal skin of P42 female NIH mice and NIH hairless mice was sequenced by RNA-Seq, and 5,068 differentially expressed genes (DEGs) were identified (false discovery rate [FDR] ≥ 2, P < 0. Read More

    Multiple Primary Recurrent Basaliomas (mPR-BCCs) of the Scalp with Cranial Bone Invasion.
    Open Access Maced J Med Sci 2017 Jul 25;5(4):564-565. Epub 2017 Jul 25.
    Department of Dermatology and Allergology, Academic Friedrichstrasse 41, 01067, Dresden, Germany.
    We present a 68-year-old patient with multiple primary infiltrative BCCs in the scalp area, initially treated 14 years ago with superficial contact X-ray therapy, end dose 60 greys, followed by electrocautery (x2) several years later. He presented in the dermatologic policlinic for diagnosis and therapy of two additional, newly-formed pigmented lesions, and because of an uncomfortable, itchy, burning sensation in the area where lesions had been treated years before. Screening cranial computer-tomography (CT) examination revealed two deformities in the form of tumor-mediated osteolysis, affecting the diploe of the tabula externa on the left parietal and parasagittal areas. Read More

    Dermatosurgery Rounds - The Island SKIN Infraorbital Flap.
    Open Access Maced J Med Sci 2017 Jul 23;5(4):554-555. Epub 2017 Jul 23.
    Onkoderma/ADCRSTR cooperation Group- Policlinic for Dermatology, Venereology and Dermatologic Surgery, General Skobelev 26, Sofia, Bulgaria.
    The main objective in dermatologic surgery is complete excision of the tumour while achieving the best possible functional and cosmetic outcome. Also we must take into account age, sex, and tumour size and site. We should also consider the patient's expectations, the preservation of the different cosmetic units, and the final cosmetic outcome. Read More

    Mushroom-Like Skin Tumours: Report of Three Cases.
    Open Access Maced J Med Sci 2017 Jul 21;5(4):515-517. Epub 2017 Jul 21.
    Department of Dermatology, Venereology and Dermatologic Surgery, Medical Institute of Ministry of Interior, and Onkoderma Policlinic for Dermatology and Dermatologic Surgery, Sofia, Bulgaria.
    Mushroom like the growth of skin tumour is a rare phenomenon although described already in 1806 by Alibert, who focused on mycosis fungicides. We identified only four case reports in PUBMED database using the terms "mushroom-like growth" and "skin tumour". We analysed our files and identified three elderly female patients (69 to 94 years old). Read More

    Basal Cell Carcinoma Surgery: Simple Undermining Approach in Two Patients with Different Tumour Locations.
    Open Access Maced J Med Sci 2017 Jul 24;5(4):506-510. Epub 2017 Jul 24.
    Department of Pathology, University of Virginia Health System, 1215 Lee Street, Box 800214, Charlottesville, VA 22908, USA.
    Basal cell carcinoma (BCC) is the most common human malignancy, accounting for the majority of all non-melanoma skin cancers (NMSC). In the past several decades the worldwide incidence of BCC has constantly been increasing. Even though it is a slow growing tumour that, left untreated, rarely metastasizes, it has a distinctive invasive growth pattern, posing a considerable risk for local invasion and destruction of underlying tissues, such as muscle, cartilage, bone or vital structures. Read More

    Pigmented Paraaxillary Located "Complex" Basal Cell Carcinoma Imitating clinically irritated Melanocytic Lesion - Succesfull Surgical Approach in Bulgarian Patient.
    Open Access Maced J Med Sci 2017 Jul 24;5(4):497-500. Epub 2017 Jul 24.
    Medical Institute of Ministry of Interior (MVR), Department of Dermatology and Dermatologic Surgery, General Skobelev 79, 1606 Sofia, Bulgaria; Onkoderma" - Policlinic for Dermatology, Venereology and Dermatologic Surgery, 26 General Skobelev blvd., Sofia, Bulgaria.
    Background: Basal cell carcinoma (BCC) is the most frequently encountered neoplasm worldwide. While nodular BCC is the most frequent clinical subtype, other forms of BCC, such as superficial, cystic, morpheiform, infiltrative, and pigmented may also be encountered.

    Case Presentation: We present the case of a 67-year-old male with a relatively well-defined infiltrative, pigmented plaque with multiple colours and peripheral growth situated in the right axillary region. Read More

    Fibroepithelioma of Pinkus (FeP) Located in the Left Lower Quadrant of the Abdomen - Case Report and Review of the Literature.
    Open Access Maced J Med Sci 2017 Jul 19;5(4):439-444. Epub 2017 Jul 19.
    Medical Institute of Ministry of Interior (MVR), Department of Dermatology and Dermatologic Surgery, General Skobelev 79, 1606 Sofia, Bulgaria; Onkoderma - Policlinic for Dermatology, Venereology and Dermatologic Surgery, 26 General Skobelev blvd., Sofia, Bulgaria.
    Background: Fibroepithelioma of Pinkus (FeP) is an uncommon and controversial skin lesion, sharing features of both basal cell carcinoma (BCC) and trichoepithelioma. In this article, we present a case of FeP and synthesise current concepts on the etiopathogenesis, diagnosis and treatment of this uncommon tumour.

    Case Report: We report the case of an 88-year-old male patient presenting to the dermatology clinic for a sharply demarcated, pink, exophytic cutaneous tumour situated in the left inguinal region. Read More

    Decreased expression of the mitochondrial solute carrier SLC25A43 in basal cell carcinoma compared with healthy skin.
    Oncol Lett 2017 Aug 21;14(2):2218-2222. Epub 2017 Jun 21.
    Department of Clinical Research Laboratory, Faculty of Medicine and Health, Örebro University, SE-701 82 Örebro, Sweden.
    Basal cell carcinoma is the most common type of cancer in fair-skinned individuals, and its incidence is rapidly increasing. The aim of the present study was to investigate the gene and protein expression of the mitochondrial solute carrier family 25 member 43 (SLC25A43) in basal cell carcinoma. SLC25A43 has previously been identified to be genetically altered and associated with cell proliferation in human epidermal growth factor receptor 2-positive breast cancer. Read More

    Risk of cutaneous squamous cell carcinoma after treatment of basal cell carcinoma with vismodegib.
    J Am Acad Dermatol 2017 Aug 2. Epub 2017 Aug 2.
    Department of Dermatology, University of California San Francisco, San Francisco, California.
    Background: Vismodegib is a first-in-class agent targeting the hedgehog signaling pathway for treatment of patients with locally advanced basal cell carcinoma (BCC) and metastatic BCC. There have been concerns about the development of squamous cell carcinoma (SCC) in patients treated with this drug.

    Objective: We sought to determine whether treatment with vismodegib is associated with an increase in the risk of cutaneous SCC. Read More

    Effect of voriconazole on risk of nonmelanoma skin cancer after hematopoietic cell transplantation.
    J Am Acad Dermatol 2017 Aug 2. Epub 2017 Aug 2.
    Department of Dermatology, Stanford University School of Medicine, Stanford, California. Electronic address:
    Background: Voriconazole has previously been associated with increased risk for cutaneous squamous cell carcinoma (SCC) in solid organ transplant recipients. Less is known about the risk in patients after hematopoietic cell transplantation (HCT).

    Objective: We evaluated the effect of voriconazole on the risk for nonmelanoma skin cancer (NMSC), including SCC and basal cell carcionoma, among those who have undergone allogeneic and autologous HCT. Read More

    Synthesis and evaluation of vitamin D3 analogues with C-11 modifications as inhibitors of Hedgehog signaling.
    Bioorg Med Chem Lett 2017 Jul 24. Epub 2017 Jul 24.
    Department of Pharmaceutical Sciences, University of Connecticut, 69 North Eagleville Rd, Unit 3092, Storrs, CT 06269-3092, USA. Electronic address:
    Previous structure-activity relationship studies have provided potent and selective analogues of vitamin D3 as inhibitors of the Hedgehog (Hh) signaling pathway. These analogues contain both modified A- and seco-B ring motifs, and have been evaluated for anticancer therapeutic potential. To continue our studies on this scaffold, a new series of compounds were synthesized to explore additional interactions and spatial constraints. Read More

    Vulvar Neoplasms, Benign and Malignant.
    Obstet Gynecol Clin North Am 2017 Sep;44(3):339-352
    Bethesda Dermpath Laboratory, 1730 Elton Road, Suite 11, Silver Spring, MD 20903, USA; Anne Arundel Dermatology, Towson, MD 21204, USA; Pathology, Johns Hopkins University, 4940 Bayview Medical Center, Eastern Avenue, Baltimore, MD 21224, USA. Electronic address:
    Cutaneous vulvar neoplasms are commonly encountered at gynecology visits, with 2% of women having a benign vulvar melanocytic nevus and 10% to 12% of nevi being vulvar. High-grade squamous intraepithelial lesions (vulvar intraepithelial neoplasia 2 or 3) occurs in 5 per 100,000 women, with increasing incidence in the past 30 years. The recognition of these lesions and differentiation between benign, premalignant, and malignant stages are crucial for adequate diagnosis, clinical monitoring, and treatment. Read More

    Vitamin D3 Produced by Skin Exposure to UVR Inhibits Murine Basal Cell Carcinoma Carcinogenesis.
    J Invest Dermatol 2017 Jul 31. Epub 2017 Jul 31.
    All - UCSF Benioff Children's Hospital Oakland Research Institute, Oakland, California.
    The effect of ultraviolet radiation (UVR) on human basal cell carcinoma (BCC) epidemiology is complex - the incidence rises until approximately 30,000 hours of lifetime sunlight exposure and then plateaus. We hypothesize that UVR has opposing effects on BCC carcinogenesis - stimulatory via mutagenesis, etc. and inhibitory via production of hedgehog-inhibiting vitamin D3 (D3). Read More

    In vivo measurements of blood vessels' distribution in non-melanoma skin cancer by dynamic optical coherence tomography - a new quantitative measure?
    Skin Res Technol 2017 Aug 3. Epub 2017 Aug 3.
    Department of Dermatology, Zealand University Hospital, University of Copenhagen, Roskilde, Denmark.
    Background: Skin biopsies only provide point-in-time data making longitudinal studies difficult. Using Dynamic optical coherence tomography (D-OCT) in vivo, non-invasive imaging of the microvasculature becomes possible. The current OCT literature is almost exclusively based on qualitative information but quantitative data may offer additional advantages, for example, by reducing observer variation. Read More

    [The Dutch College of General Practitioners practice guideline 'Suspicious skin lesions'].
    Ned Tijdschr Geneeskd 2017 ;161(0):D1897
    *Namens de NHG-werkgroep Verdachte huidafwijkingen, waarvan de leden aan het eind van dit artikel vermeld staan.
    - The Dutch College of General Practitioners practice guideline 'Suspicious skin lesions' provides recommendations for diagnosis, treatment and referral for the most common premalignant and malignant skin disorders.- The practice guideline includes a flowchart which starts by looking at the colour and surface of the skin lesion to direct the general practitioner to the most likely diagnosis.- In case of strong suspicion of squamous cell carcinoma, keratoacanthoma or melanoma and in case of basal cell carcinoma or Bowen's disease with high-risk characteristics, the general practitioner will refer the patient to a dermatologist. Read More

    Metal arc welding and the risk of skin cancer.
    Int Arch Occup Environ Health 2017 Aug 1. Epub 2017 Aug 1.
    Department of Occupational and Environmental Medicine, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.
    Objectives: Arc welding produces the full spectrum of ultraviolet radiation and may be a contributory cause of skin cancer; however, there has been little research into this occupational hazard. The aim of this study is to explore if metal arc welding increases the risk of malignant melanoma and/or basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) on skin areas which may possibly be exposed (neck, head, and upper extremities).

    Method: A Danish national company-based historic cohort of 4333 male metal arc welders was followed from 1987 through 2012 to identify the risk of skin cancer. Read More

    Evaluation of Hypoxia Inducible Factor-1α and Glucose Transporter-1 Expression in Non Melanoma Skin Cancer: An Immunohistochemical Study.
    J Clin Diagn Res 2017 Jun 1;11(6):EC09-EC16. Epub 2017 Jun 1.
    Resident, Department of Dermatology, Andrology and S.T.Ds, Faculty of Medicine, Menoufia University, Egypt.
    Introduction: Hypoxia Inducible Factor-1 (HIF-1) is a mediator enabling cell adaptation to hypoxia. It plays its role mainly through transcription of many target genes including Glucose Transporter-1 (GLUT-1) gene.

    Aim: The present work aimed at evaluating the pattern and distribution of HIF-1α and GLUT-1 in each case and control. Read More

    Enhanced Visualization of Hematoxylin and Eosin Stained Pathological Characteristics by Phasor Approach.
    Anal Chem 2017 Aug 16. Epub 2017 Aug 16.
    Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University , Shenzhen 518060, China.
    The phasor approach to fluorescence lifetime imaging microscopy (FLIM) is used to identify different types of tissues from hematoxylin and eosin (H&E) stained basal cell carcinoma (BCC) sections. The results suggest that working directly on the phasor space with the clustering assignment achieves immunofluorescence like simultaneous five or six-color imaging by using multiplexed fluorescence lifetimes of H&E. The phase approach is of particular effectiveness for enhanced visualization of the abnormal morphology of a suspected nidus. Read More

    Phaeohyphomycosis of the Face Masquerading as Basal Cell Carcinoma in an Immunocompetent Patient.
    Indian Dermatol Online J 2017 Jul-Aug;8(4):271-273
    Department of Pathology, National Institute of Pathology, New Delhi, India.
    Pheohyphomycosis is a rare heterogeneous group of mycotic infections caused by dermatiaceous (phaeoid) fungi affecting the skin, subcutaneous tissue, and the central nervous system.Involvement of the face is extremely rare, and very few cases have been reported in India so far. We reporta case of phaeohyphomycosisin a 45-year-old female with 1-year history of a well- defined hypertrophic plaque over the right cheek advancing towards the forehead. Read More

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