Cancer Prev Res (Phila) 2017 Aug 18. Epub 2017 Aug 18.
Lungs for Living Research Centre, UCL Respiratory, University College London, London, United Kingdom.
Basal cells are stem/progenitor cells that maintain airway homeostasis, enact repair following epithelial injury, and are a candidate cell-of-origin for lung squamous cell carcinoma. Heterogeneity of basal cells is recognized in terms of gene expression and differentiation capacity. In this Issue, Pagano and colleagues isolate a subset of immortalized basal cells that are characterized by high motility, suggesting that they might also be heterogeneous in their biophysical properties. Read More