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    Cyclooxygenase-2 expression and association with skin cancer: A meta-analysis based on Chinese patients.
    J Cancer Res Ther 2016 Dec;12(Supplement):C288-C290
    Department of Thyroid and Breast Surgery, The Sixth Affiliated Hospital of Wenzhou Medical University, People's Hospital, Lishui, China.
    Objective: The purpose of this meta-analysis was to evaluate the association between cyclooxygenase-2 (Cox-2) expression and skin cancer.

    Materials And Methods: We searched the databases of PubMed, CNKI, and WANFANG to find the case-control studies associated with Cox-2 expression and skin cancer. The association between Cox-2 expression and skin cancer was demonstrated by odds ratio (OR) and its 95% confidence interval (95% CI). Read More

    Automated basal cell carcinoma detection in high-definition optical coherence tomography.
    Conf Proc IEEE Eng Med Biol Soc 2016 Aug;2016:2885-2888
    Basal cell carcinoma (BCC) is the most common non-melanoma skin cancer. Conventional diagnosis of BCC requires invasive biopsies. Recently, a high-definition optical coherence tomography (HD-OCT) technique has been developed, which provides a non-invasive in vivo imaging method of skin. Read More

    Cutaneous Lymphadenoma: A Trichoblastoma with Regressive Inflammatory Changes.
    Facial Plast Surg 2017 Feb 22;33(1):109-111. Epub 2017 Feb 22.
    Department of Otolaryngology-Head and Neck Surgery, Joan and Sanford I Weill Medical College of Cornell University, New York, New York.
    The authors address the entity of cutaneous lymphadenoma. Although considered benign, cutaneous lymphadenoma can be easily misdiagnosed as basal cell carcinoma because of its close clinical and histological resemblance. This entity is rare and controversial both in terms of its histogenesis and the various diagnostic terms assigned to it throughout the literature. Read More

    Recurrence rate of basal cell carcinoma with positive histopathological margins and related risk factors.
    An Bras Dermatol 2017 Jan-Feb;92(1):58-62
    Faculdade Evangélica do Paraná (FEPAR) - Curitiba (PR), Brazil.
    Background:: The best way to approach surgically removed basal cell carcinoma with positive histopathological margins is a controversial issue. Some authors believe that the more appropriate treatment is an immediate reoperation while others prefer a periodic follow up. The rates of recurrence are variable in literature, between 10% and 67%. Read More

    Initial basal cell carcinomas diagnosed in the National Campaign for Skin Cancer Prevention are smaller than those identified by the conventional medical referral system.
    An Bras Dermatol 2017 Jan-Feb;92(1):26-29
    Department of Dermatology and Radiotherapy - Faculdade de Medicina de Botucatu - Universidade Estadual Paulista "Júlio de Mesquita Filho" (FMB-UNESP) (UNESP) - Botucatu (SP), Brazil.
    Background:: Basal cell carcinoma is the malignant tumor most often diagnosed in the National Campaign for Skin Cancer Prevention (NCSCP). Little is known about the profile of these lesions compared to the profile of lesions diagnosed by conventional routes of public dermatological care.

    Objective:: To identify if basal cell carcinomas identified in prevention campaigns and referred to surgery are smaller than those routinely removed in a same medical institution. Read More

    Non-melanoma skin cancer and risk of Alzheimer's disease and all-cause dementia.
    PLoS One 2017 22;12(2):e0171527. Epub 2017 Feb 22.
    Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
    Cancer patients may be at decreased risk of Alzheimer's disease. This hypothesis is best developed for non-melanoma skin cancer (NMSC), but supportive epidemiological data are sparse. We therefore conducted a nationwide cohort study of the association between NMSC and Alzheimer's disease (main outcome) and all-cause dementia. Read More

    Ingenol Mebutate Topical Gel A Status Report On Clinical Use Beyond Actinic Keratosis.
    J Clin Aesthet Dermatol 2016 Nov;9(11 Suppl 1):S3-S11
    Adjunct Clinical Professor (Dermatology), Touro University Nevada, Henderson, Nevada; Research Director, Del Rosso Dermatology Research Center, Las Vegas, Nevada.
    Ingenol mebutate is available as a topical gel formulation approved for the treatment of actinic keratosis. Two different concentrations are available for treatment of actinic keratoses at specific anatomic sites with the advantages of short durations of therapy and limited "down time" related to visible inflammation as compared to other topical agents. Due to the various modes of action of ingenol mebutate, it has also been used for treatment of disease states other than actinic keratosis. Read More

    Secondary Cutaneous Amyloidosis in a Patient with Mycosis Fungoides.
    Ann Dermatol 2017 Feb 3;29(1):79-82. Epub 2017 Feb 3.
    Department of Dermatology, Dankook University Medical College, Cheonan, Korea.
    Secondary cutaneous amyloidosis refers to clinically unapparent amyloid deposits within the skin in association with a pre-existing skin condition or skin tumors, such as basal cell carcinoma, porokeratosis, solar elastosis, Bowen's disease, and mycosis fungoides. A 70-year-old woman presented with a 6-month history of asymptomatic multiple yellowish plaques on both legs. She had been diagnosed with mycosis fungoides 7 years ago and was treated with psoralen and ultraviolet A radiation (PUVA) therapy, narrow-band ultraviolet B (UVB) therapy, and acitretin for 5 years. Read More

    Long-term results after treatment of basal cell carcinoma of the eyelid in South-Western Finland.
    Eur J Ophthalmol 2007 Jul-Aug;17:494-500
    Department of Ophthalmology, University of Turku, Turku - Finland and Department of Ophthalmology, S.
    .

    Purpose: Basal cell carcinoma (BCC) is the most common skin cancer of the eyelid, showing an increasing incidence in the white population. The authors studied the clinical characteristics and the treatment results of BCC of the eyelid in southwestern Finland during 1977-1997. Read More

    Thermal Burn Scar-Related Squamous Cell Carcinoma in the Eyelid.
    Ophthal Plast Reconstr Surg 2017 Feb 17. Epub 2017 Feb 17.
    *Ophthalmology Department, Uludag University and †Bursa Pathology Center, Bursa, Turkey.
    A 63-year-old woman presented with a large, ulcerokeratotic mass in her right lower eyelid that had grown over the last 2 months in a burn scar. She had experienced a thermal burn involving both inferior periorbital areas 35 years ago and received medical treatment. The lesion was excised with wide margins. Read More

    Epidemiology of basal cell carcinoma: scholarly review.
    Br J Dermatol 2017 Feb 20. Epub 2017 Feb 20.
    Department of Dermatology, Erasmus MC Cancer Institute, Burgemeester s'Jacobplein 51, 3015 CA, Rotterdam, the Netherlands.
    Basal cell carcinoma (BCC) is the most common cancer in white-skinned individuals with increasing incidence rates worldwide. Patients with BCC place a large burden on healthcare systems, because of the high incidence and the increased risk of synchronous and metachronous BCCs and other ultraviolet radiation (UVR) related skin cancers (i.e. Read More

    Multiple nonsyndromic acquired basal cell carcinomas : Uncommon clinical presentation in a Bulgarian patient.
    Wien Med Wochenschr 2017 Feb 20. Epub 2017 Feb 20.
    Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Friedrichstrasse 41, 01067, Dresden, Germany.
    Basal cell carcinoma is the most frequent cutaneous neoplasm, with slowly progressive nature and locally invasive behavior. Despite the low metastatic potential, local tissue destruction and disfigurement caused by the tumor can be large if not eradicated in time by early diagnosis and treatment. Both genetic predisposition and exposure to environmental risks are involved in the pathogenesis of the malignant transformation in BCC. Read More

    Diagnostic accuracy of reflectance confocal microscopy using VivaScope for detecting and monitoring skin lesions: a systematic review.
    Clin Exp Dermatol 2017 Feb 20. Epub 2017 Feb 20.
    BMJ Technology Assessment Group, BMJ, London, UK.
    Background: Skin cancer is one of the most common cancers in the UK. Patients with suspicious skin lesions are assessed clinically with/without dermoscopy, and lesions still considered suspicious are then surgically removed or have the diagnosis confirmed by a punch biopsy.

    Aim: To evaluate the diagnostic accuracy of the in vivo VivaScope(©) reflective confocal microscopy (RCM) system, a noninvasive technology designed to provide a more accurate presurgical diagnosis, leading to fewer biopsies of benign lesions, or to provide greater accuracy for lesion margins. Read More

    Risk of Non-melanoma Skin Cancer in Patients with Atopic Dermatitis Treated with Oral Immunosuppressive Drugs.
    Acta Derm Venereol 2017 Feb 20. Epub 2017 Feb 20.
    Department of Dermatology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
    There is uncertainty about the risk of developing non-melanoma skin cancer (NMSC), including basal cell carcinoma and squamous cell carcinoma (SCC), in patients with atopic dermatitis (AD) treated with oral immunosuppressive drugs. A total of 557 patients with AD treated with these drugs in the University Medical Center Utrecht and Groningen, the Netherlands, were analysed. NMSC after oral immunosuppressive treatment was reported in 18 patients (3. Read More

    High Altitude Dermatology.
    Indian J Dermatol 2017 Jan-Feb;62(1):59-65
    Department of Dermatology, Military Hospital, Ahmedabad, Gujarat, India.
    Approximately, 140 million people worldwide live permanently at high altitudes (HAs) and approximately another 40 million people travel to HA area (HAA) every year for reasons of occupation, sports or recreation. In India, whole of Ladakh region, part of Northwest Kashmir, Northern part of Sikkim and Tenga valley of Arunachal are considered inhabited areas of HAA. The low quantity of oxygen, high exposure of ultraviolet (UV) light, very low humidity, extreme subzero temperature in winter, high wind velocity, make this region difficult for lowlanders as well as for tourists. Read More

    Expression Profiling of Clinical Specimens Supports the Existence of Neural Progenitor-Like Stem Cells in Basal Breast Cancers.
    Clin Breast Cancer 2017 Jan 27. Epub 2017 Jan 27.
    Department of Surgery, Section of Otolaryngology, Yale School of Medicine, New Haven, CT. Electronic address:
    Background: We previously characterized in salivary adenoid cystic carcinoma (ACC) a novel population of cancer stem cells (CSCs) marked by coexpression of 2 stemness genes, sex-determining region Y (SRY)-related HMG box-containing factor 10 (SOX10) and CD133. We also reported that in ACC and basal-like breast carcinoma (BBC), a triple-negative breast cancer subtype, expression of SOX10 similarly demarcates a highly conserved gene signature enriched with neural stem cell genes. On the basis of these findings, we hypothesized that BBC might be likewise driven by SOX10-positive (SOX10(+))/CD133(+) cells with neural stem cell properties. Read More

    GATA3 expression and its relationship with clinicopathological parameters in invasive breast carcinomas.
    Pathol Res Pract 2017 Jan 10. Epub 2017 Jan 10.
    Gazi University, School of Medicine, Department of Pathology, Ankara, Turkey. Electronic address:
    GATA3, as a transcription factor, is associated with estrogen receptor (ER) expression and necessary for luminal cell differentiation in mammary glands. Association of GATA3 expression with clinicopathological parameters, molecular subtypes of tumors, disease free survival (DFS) and overall survival (OS) for breast carcinoma patients were evaluated in this study. We immunohistochemically stained GATA3, CK5/6, EGFR, CK14 and vimentin on tissue microarray blocks of 457 invasive breast carcinomas. Read More

    Influence of oxygen partial pressure on the characteristics of human hepatocarcinoma cells.
    Redox Biol 2017 Feb 13;12:103-113. Epub 2017 Feb 13.
    Department of Physiology, Medicine and Nursing School, University of the Basque Country UPV/EHU, 48940 Leioa, Spain. Electronic address:
    Most of the in vitro studies using liver cell lines have been performed under atmospheric oxygen partial pressure (21% O2). However, the oxygen concentrations in the liver and cancer cells are far from this value. In the present study, we have evaluated the influence of oxygen on 1) the tumor cell lines features (growth, steady-state ROS levels, GSH content, activities of antioxidant enzymes, p66 Shc and SOD expressions, metalloproteinases secretion, migration, invasion, and adhesion) of human hepatocellular carcinoma cell lines, and b) the response of the cells to an oxidant stimulus (aqueous leaf extract of the V. Read More

    Primary acinic cell carcinoma of the lung with psammoma bodies: A case report and review of literature.
    Pathol Res Pract 2017 Jan 19. Epub 2017 Jan 19.
    Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences of China Medical University, Shenyang 110001, China.
    Salivary gland-type tumors are rare in the lung. Primary acinic cell carcinoma of the lung is extremely rare. Here, we report a case of primary acinic cell carcinoma of the lung with prominent psammoma bodies. Read More

    Itraconazole exerts its anti-melanoma effect by suppressing Hedgehog, Wnt, and PI3K/mTOR signaling pathways.
    Oncotarget 2017 Feb 14. Epub 2017 Feb 14.
    Department of Mycology, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.
    Malignant melanoma is the deadliest form of all skin cancers. Itraconazole, a commonly used systemic antifungal drug, has been tested for its anti-tumor effects on basal cell carcinoma, prostate cancer, and non-small cell lung cancer. Whether itraconazole has any specific anti-tumor effect on melanoma remains unknown. Read More

    High-dose Rate Electronic Brachytherapy: A Nonsurgical Treatment Alternative for Nonmelanoma Skin Cancer.
    J Clin Aesthet Dermatol 2016 Nov 1;9(11):16-22. Epub 2016 Nov 1.
    Strimling Dermatology, Laser, and Vein Institute, Las Vegas, Nevada.
    The authors summarized data from a group of physicians with experience using high-dose rate electronic brachytherapy for the treatment of nonmelanoma skin cancer. The data have been published or presented in abstract format at national dermatology and radiation oncology meetings. The data included 1,822 treated lesions from 2009 to 2014 in patients ranging in age from 52 to 104 years. Read More

    Basal cell carcinoma arising in outdoor workers versus indoor workers: a retrospective study.
    Cutis 2017 Jan;99(1):55-60
    Department of Dermatology, San Cecilio University Hospital, Granada, Spain.
    Basal cell carcinoma (BCC) is the most prevalent malignancy in white individuals and continues to be a serious health problem. Individuals who have sustained exposure to UV radiation are at the highest risk for developing BCC. The aim of this study was to compare the features of BCC in outdoor workers (OWs) with a history of occupational exposure to UV radiation versus indoor workers (IWs). Read More

    Elevated basal antibody-dependent cell-mediated cytotoxicity (ADCC) and high epidermal growth factor receptor (EGFR) expression predict favourable outcome in patients with locally advanced head and neck cancer treated with cetuximab and radiotherapy.
    Cancer Immunol Immunother 2017 Feb 14. Epub 2017 Feb 14.
    Laboratory of Cancer Genetics and Translational Oncology, Oncology Department, S. Croce & Carle Teaching Hospital, via Carle 25, 12100, Cuneo, Italy.
    Background: Antibody-dependent cell-mediated cytotoxicity (ADCC) may contribute to the antitumor activity of cetuximab. However, the extent of this contribution is unclear. In this study, we investigated the impact of baseline ADCC on the outcome of patients with locally advanced squamous cell carcinoma treated with cetuximab and radiotherapy. Read More

    Factors predicting pain and effect of oral analgesia in topical photodynamic therapy.
    Photodermatol Photoimmunol Photomed 2017 Feb 14. Epub 2017 Feb 14.
    Department of Dermatology, Mater Misericordiae University Hospital, Dublin.
    Topical photodynamic therapy (PDT) is highly efficacious for the treatment of actinic keratosis (AK), Bowen's disease (BD) and superficial basal cell carcinoma (sBCC), and efficacious in thin nodular BCCs (nBCC).(1) It is generally well tolerated, with pain or discomfort being a known side-effect.(1) Pain is typically described as a burning or stinging sensation of varying intensity. Read More

    An Analysis of Laser Therapy for the Treatment of Nonmelanoma Skin Cancer.
    Dermatol Surg 2017 Feb 9. Epub 2017 Feb 9.
    *Department of Dermatology, Stanford University School of Medicine, Palo Alto, California; †Department of Dermatology, University of California, Irvine, Irvine, California.
    Background: Skin cancer remains the most prevalent type of cancer in the United States, and its burden on the health care system remains substantial. Standard treatments such as cryosurgery, electrodessication and curettage, topical and photodynamic therapies, and surgical excision including Mohs micrographic surgery are not without inherent morbidity, including risk of bleeding, infection, and scar.

    Objective: Lasers may be an alternative for treatment of nonmelanoma skin cancer, and this paper reviews this therapeutic option. Read More

    Molecular classification of urothelial carcinoma: global mRNA classification versus tumour-cell phenotype classification.
    J Pathol 2017 Feb 13. Epub 2017 Feb 13.
    Division of Oncology and Pathology, Department of Clinical Sciences, Lund University, Lund, Sweden.
    Global mRNA expression analysis is efficient for phenotypic profiling of tumours and has been used to define molecular subtypes for almost every major tumour type. A key limitation is that most tumours are communities of both tumour and non-tumour cells. This problem is particularly pertinent when analysing advanced invasive tumours, known to induce major changes and responses in both the tumour and the surrounding tissue. Read More

    Practical indications for the management of non--melanoma skin cancer patients.
    G Ital Dermatol Venereol 2017 Feb 14. Epub 2017 Feb 14.
    Institue of Dermatology, Catholic University of Rome, Rome, Italy.
    Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), together encompassed in the term non--melanoma skin cancers (NMSC), are the most common cancers among fair--skinned populations. Individuating accurate risk stratification of NMSC patients is crucial to select different options among various treatment strategies. The majority of low risk NMSCs are easily treated with surgery, offering excellent cure rates and cosmetic results. Read More

    Trichoblastic carcinoma of the scalp with rippled pattern.
    Indian J Pathol Microbiol 2017 Jan-Mar;60(1):97-98
    Department of Plastic Surgery, Istanbul Training and Research Hospital, Istanbul, Turkey.
    Trichoblastic carcinoma (TC) is a rare type of malignancy which is derived from the hair follicles. In this paper, we report a case with TC on the scalp characterized with rippled pattern. There have been reports of rippled pattern in trichoblastomas, sebaceomas, and basal cell carcinomas. Read More

    Undermining plastic surgery as a possible option for treating basal cell carcinoma of the forehead.
    Wien Med Wochenschr 2017 Feb 13. Epub 2017 Feb 13.
    Department of Pathology, University of Virginia Health System, 1215 Lee Street, 800214, 22908, Charlottesville, VA, USA.
    Basal cell carcinoma (BCC) is the most common cutaneous cancer. Although most cases can be cured with simple surgical procedures and are associated with a good prognosis, a minority of BCCs may pose significant therapeutic challenges. This occurs mostly in cases of so-called advanced BCC, which a loosely defined term that encompasses locally advanced lesions and tumors with metastatic spread. Read More

    Basal cell carcinoma arising in a congenital melanocytic naevus in an adult.
    BMJ Case Rep 2017 Feb 13;2017. Epub 2017 Feb 13.
    Queen Victoria Hospital NHS Foundation Trust, East Grinstead, West Sussex, UK.
    Congenital melanocytic naevi (CMN) are common skin lesions. They harbour a risk of malignant transformation, and various lesions have been described as developing within them. A basal cell cancer occurring within a CMN has never previously been described. Read More

    Changes in the Incidence of Skin and Lip Cancer Between 1978 and 2007.
    Actas Dermosifiliogr 2017 Feb 9. Epub 2017 Feb 9.
    Facultad de Medicina, Universidad de Granada, Granada, España.
    Introduction: The aim of this study was to analyze trends in the incidence of skin cancer worldwide, in Europe, and in Spain between 1978 and 2007.

    Material And Methods: Skin cancer incidence and trends for the period 1978 to 2007 were investigated using the age- and sex-standardized rates (per 100,000 population) published in the Cancer Incidence in Five Continents series.

    Results: The incidence of cutaneous melanoma increased progressively from 1978 to 2002 but decreased in the last period analyzed (2003-2007). Read More

    Loss of PAR-3 protein expression is associated with invasion, lymph node metastasis, and poor survival in esophageal squamous cell carcinoma.
    Hum Pathol 2017 Feb 8. Epub 2017 Feb 8.
    Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto, 602-8566, Japan.
    Disrupted cell polarity is a feature of epithelial cancers. The partitioning defective 3 (PAR-3) protein, a key component of the PAR complex that regulates the polarization of cells, is involved in tight junction formation at epithelial cell-cell contacts. Our previous study detected a homozygous deletion of the PAR-3 gene in esophageal squamous cell carcinoma (ESCC) cell lines and frequent copy number loss of the PAR-3 gene in primary ESCC. Read More

    Two intermittent vismodegib dosing regimens in patients with multiple basal-cell carcinomas (MIKIE): a randomised, regimen-controlled, double-blind, phase 2 trial.
    Lancet Oncol 2017 Feb 7. Epub 2017 Feb 7.
    Klinik für Dermatologie, Venereologie und Allergologie, Universitätsklinikum Essen, Essen, Germany.
    Background: Vismodegib, a first-in-class Hedgehog-pathway inhibitor, is approved for use in adults with advanced basal-cell carcinoma. Patients with multiple basal-cell carcinomas, including those with basal-cell nevus (Gorlin) syndrome, need extended treatment. We assessed the safety and activity of two long-term intermittent vismodegib dosing regimens in patients with multiple basal-cell carcinomas. Read More

    Expression of oncogenic miR-17-92 and tumor suppressive miR-143-145 clusters in basal cell carcinoma and cutaneous squamous cell carcinoma.
    J Dermatol Sci 2017 Jan 31. Epub 2017 Jan 31.
    Dermatologic Surgery Unit, Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum, 44791 Bochum, Germany.
    Background: A variety of cancers are associated with the expression of the oncogenic miR-17-92 cluster (Oncomir-1) and tumor suppressor miR-143-5p/miR-145-5p. Epidermal skin cancer has not been investigated for the expression of miR-17-92 and miR-143-145 clusters, despite being extensively studied regarding global microRNA profiles. The goal of this study was to investigate the expression and possible correlation of expression of miR17-92 and miR-143-145 cluster members in epidermal skin cancer. Read More

    Differential pharmacology and clinical utility of sonidegib in advanced basal cell carcinoma.
    Onco Targets Ther 2017 24;10:515-520. Epub 2017 Jan 24.
    Research and Scientific Studies Unit, College of Nursing and Allied Health Sciences, Jazan University, Jazan, Kingdom of Saudi Arabia.
    Patients suffering from advanced basal cell carcinoma (BCC) have very limited treatment options. Sonidegib selectively inhibits the growth of Hedgehog pathway-dependent tumors and can treat locally advanced BCC patients who are not candidates for surgery or radiation therapy. The BOLT clinical trials were conducted to evaluate the efficacy/potency of sonidegib in the treatment of advanced BCC or metastatic BCC. Read More

    Update on Surgical Outcomes of Lateral Temporal Bone Resection for Ear and Temporal Bone Malignancies.
    J Neurol Surg B Skull Base 2017 Feb 10;78(1):37-42. Epub 2016 Jun 10.
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States.
    Objectives Review outcomes of lateral temporal bone resections for ear and temporal bone malignancy. Design, Setting, and Participants Retrospective review of all lateral temporal bone resections performed from 2008 to 2015 at a single tertiary care center. Main Outcome Measures Patient demographics, perioperative variables, overall survival, disease-free survival (DFS), and comparison of Kaplan-Meier curves. Read More

    Optical Coherence Tomography Imaging of Basal Cell Carcinoma Undergoing Photodynamic Therapy: A Pilot Study.
    Photodiagnosis Photodyn Ther 2017 Feb 5. Epub 2017 Feb 5.
    Department of Dermatology and Allergology, Ludwig Maximilian University, Frauenlobstr. 9-11, 80337 Munich, Germany; Department of Dermatology, Municipal Hospital of Munich, Thalkirchner Str. 48, 80337 Munich, Germany.

    Incidence of lip malignancies in Germany - data from 9 population-based cancer registries.
    J Oral Pathol Med 2017 Feb 8. Epub 2017 Feb 8.
    Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Centre, Johannes Gutenberg University Mainz, Mainz, Germany.
    Background: The objective of this study was to analyse the incidence of lip malignancies in Germany.

    Methods: Data from population-based cancer registries covering a population of 39 million inhabitants from 14 federal states were pooled. Lip malignancies were classified according to the International Classification of Diseases (ICD-10). Read More

    Association between genetic variation within vitamin D receptor-DNA binding sites and risk of basal cell carcinoma.
    Int J Cancer 2017 Feb 8. Epub 2017 Feb 8.
    Department of Epidemiology, Richard M. Fairbanks School of Public Health, Melvin & Bren Simon Cancer Center, Indiana University, Indianapolis, IN.
    An increasing number of studies have reported a protective association between vitamin D and cancer risk. The vitamin D endocrine system regulates transcriptional programs involved in inflammation, cell growth and differentiation through the binding of vitamin D receptor (VDR) to specific VDR elements. However, limited attention has been given to the role of variation within VDR binding sites in the development of basal cell carcinoma (BCC). Read More

    Assessment of VEGF and EGFR in the study of angiogenesis of eyelid carcinomas.
    Rom J Morphol Embryol 2016 ;57(4):1229-1234
    Department of Anatomy, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania;
    A tumor represents an abnormal tissue growth that can arise from any ocular structure, such as eyelids, muscles or the optic nerve. At the eyelids, there are two main tumor types: basal cell carcinoma and squamous cell carcinoma. Angiogenesis plays a crucial role in growth, invasion and metastasis processes of any tumor. Read More

    [Primary Lung Cancer Associated with Dilated Phase of Hypertrophic Cardiomyopathy;Report of a Case].
    Kyobu Geka 2017 Feb;70(2):147-150
    Department of General, Endoscopic, Cardiovascular, Thoracic and Breast Surgery, Tsugaru General Hospital, Goshogawara, Japan.
    A 66-year-old man diagnosed as dilated phase of hypertrophic cardiomyopathy (D-HCM) was pointed out an abnormal shadow on routine chest radiography. The patient had past medical history of hypertension, congestive heart failure and chronic obstructive pulmonary disease. The computed tomography showed a 3. Read More

    Germinotropic Onychocytic Matricoma: A New Histopathologic Subtype of Onychocytic Matricoma in the Light of the Microanatomy of the Normal Nail Unit, With Special Reference to Nail Mesenchyme.
    Am J Dermatopathol 2017 Feb 2. Epub 2017 Feb 2.
    *The Laboratoire Central d'Anatomie Pathologique, Hôpital L. Pasteur, University of Nice, Nice, France; and†Nail's Dermatology Consultations, Cannes, France.
    Onychocytic matricoma (OCM) is a benign tumor of adnexal keratinocytes in which there is complete cytodifferentiation toward the germinative cells of the nail matrix, the keratogenous zone cells, and cells of the nail plate. Several microscopic variants of OCM were initially recognized; acanthotic type, acanthotic and papillomatous type, keratogenous type, and melanocytic as slight proliferation of dendritic melanocytes within the basaloid cells. This study reports an additional histopathologic variant of OCM. Read More

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