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    Naproxen Inhibits UVB-induced Basal Cell and Squamous Cell Carcinoma Development in Ptch1(+/-) /SKH-1 hairless mice.
    Photochem Photobiol 2017 Mar 22. Epub 2017 Mar 22.
    Department of Dermatology, VH509 University of Alabama at Birmingham, Birmingham, AL 35294-0019, USA.
    Naproxen possesses anti-proliferative and pro-apoptotic effects besides its known anti-inflammatory functions. Here, we demonstrate the anti-cancer effects of naproxen against UVB-induced BCCs and SCCs in a highly susceptible murine model of UVB carcinogenesis. Naproxen significantly inhibited UVB-induced BCCs and SCCs in this model. Read More

    Brain morphology in children with nevoid basal cell carcinoma syndrome.
    Am J Med Genet A 2017 Apr;173(4):946-952
    Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan.
    Brain morphology is tightly regulated by diverse signaling pathways. Hedgehog signaling is a candidate pathway considered responsible for regulating brain morphology. Nevoid basal cell carcinoma syndrome (NBCCS), caused by a PTCH1 mutation in the hedgehog signaling pathway, occasionally exhibits macrocephaly and medulloblastoma. Read More

    A cohort study of Gorlin syndrome with emphasis on standardised phenotyping and quality of life assessment.
    Intern Med J 2017 Mar 22. Epub 2017 Mar 22.
    Department of Genetic Medicine, Royal Melbourne Hospital, Parkville, VIC, 3050, Australia.
    Background: Gorlin syndrome (Nevoid Basal Cell Carcinoma Syndrome) is a rare genetic predisposition to basal cell carcinomas (BCCs), keratocysts of the jaw and calcification of the falx cerebri amongst other clinical features. With the advent of sonic hedgehog inhibitors for the treatment of BCCs, it is timely to establish a cohort of individuals with Gorlin syndrome and collect standardised phenotypic information on these individuals. Moreover, the health-related quality of life (QoL) in individuals with Gorlin syndrome is not well studied. Read More

    Current and Emerging Molecular Tests for Human Papillomavirus-Related Neoplasia in the Genomic Era.
    J Mol Diagn 2017 Mar 18. Epub 2017 Mar 18.
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Electronic address:
    Laboratory tests have a key role in preventing human papillomavirus (HPV)-driven carcinomas and in guiding therapeutic interventions. An understanding of the virology, immunology, and carcinogenesis of HPV is essential for choosing appropriate diagnostic test modalities and developing new and even more effective cancer prevention strategies. HPV infects basal epithelial cells on multiple surfaces and induces carcinoma primarily in the cervix and the oropharynx. Read More

    The role of imaging in the management of patients with nonmelanoma skin cancer: When is imaging necessary?
    J Am Acad Dermatol 2017 Apr;76(4):591-607
    Department of Dermatology, MD Anderson Cancer Center, Houston, Texas.
    When treating aggressive skin cancers, pre- and postoperative imaging provides important information for treatment planning and multidisciplinary cooperation of care. It is important for dermatologists to recognize the clinical scenarios where imaging is indicated in the management of skin cancer. We here address the most common indications for imaging in cutaneous oncology and how to best utilize the modalities available. Read More

    The role of imaging in the management of patients with nonmelanoma skin cancer: Diagnostic modalities and applications.
    J Am Acad Dermatol 2017 Apr;76(4):579-588
    Department of Dermatology, Thomas Jefferson University, Philadelphia, Pennsylvania. Electronic address:
    While uncomplicated cases of nonmelanoma skin cancer can be treated with surgery, destruction, or topical therapy alone, advanced or neglected cases require more complex management decisions. Dermatologists and dermatologic surgeons should be familiar with the imaging techniques relevant to cutaneous oncology and their value in different clinical scenarios. Herein we review imaging modalities used in management of nonmelanoma skin cancer. Read More

    GATA3 and MYB Expression in Cutaneous Adnexal Neoplasms.
    Am J Dermatopathol 2017 Apr;39(4):279-286
    *Departments of Pathology, Porto Medical School and Sao Joao Hospital, Porto, Portugal; †Departments of Pathology, William Beaumont School of Medicine, Royal Oak, MI; ‡Departments of Pathology, Duke University Medical Center, Durham, NC; and §Departments of Pathology, Harvard Medical School and Massachusetts General Hospital, Boston, MA.
    Knowledge of staining pattern of certain immunostains might be useful in the classification of cutaneous adnexal tumors that can have clinical importance. We studied GATA3 and MYB expression in archival materials of 220 adnexal tumors comprised of sebaceous carcinomas, follicular tumors, apocrine carcinoma, predominantly apocrine tumors, predominantly eccrine tumors, and others including adenoid cystic carcinomas. Nuclear GATA3 expression was seen in 70% (153/220) of cases, including sebaceous carcinoma (93%), apocrine carcinoma (93%), follicular neoplasms (100%), and predominantly apocrine neoplasms (69%), yet only 38% of predominantly eccrine neoplasms. Read More

    Nicotinamide for skin cancer chemoprevention.
    Australas J Dermatol 2017 Mar 20. Epub 2017 Mar 20.
    Discipline of Dermatology, Central Clinical School, University of Sydney at Royal Prince Alfred Hospital and Melanoma Institute Australia, Sydney, Australia.
    Nicotinamide (vitamin B3 ) has a range of photoprotective effects in vitro and in vivo; it enhances DNA repair, reduces UV radiation-induced suppression of skin immune responses, modulates inflammatory cytokine production and skin barrier function and restores cellular energy levels after UV exposure. Pharmacological doses of nicotinamide have been shown to reduce actinic keratoses and nonmelanoma skin cancer incidence in high-risk individuals, making this a nontoxic and accessible option for skin cancer chemoprevention in this population. Read More

    Skull Base Invasion Patterns and Survival Outcomes of Nonmelanoma Skin Cancers.
    J Neurol Surg B Skull Base 2017 Apr 23;78(2):164-172. Epub 2016 Nov 23.
    Department of Otolaryngology, The University of Utah, Salt Lake City, Utah, United States.
    Objective Report routes of skull base invasion for head and neck nonmelanoma skin cancers (NMSCs) and their survival outcomes. Design Retrospective. Participants Ninety patients with NMSC with skull base invasion between 2004 and 2014. Read More

    Podoplanin and SOX2 Expression in CIN 3-like Squamous Cell Carcinoma of the Cervix.
    Int J Gynecol Pathol 2017 Mar 17. Epub 2017 Mar 17.
    Department of Pathology King Edward Memorial Hospital (C.J.R.S., M.L.C.) School of Womens' and Infant's Health, University of Western Australia (C.J.R.S.), Perth, WA, Australia.
    Squamous cell carcinoma (SCC) of the uterine cervix occasionally demonstrates a deceptive growth pattern that mimics endocervical crypt involvement by cervical intraepithelial neoplasia, grade 3 (CIN 3). Such CIN 3-like SCCs may be misinterpreted as noninvasive or minimally invasive leading to delays in diagnosis. Little is known of the factors that influence the growth patterns of cervical SCC but we suggested recently that CIN 3-like tumors might demonstrate "collective cellular invasion," which is characterized by a retained epithelial phenotype. Read More

    GATA3 Expression in Benign Prostate Glands with Radiation Atypia: A Diagnostic Pitfall.
    Histopathology 2017 Mar 17. Epub 2017 Mar 17.
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL.
    Objective: Patients who have undergone prostate radiation are at an increased risk for developing urothelial carcinoma. Radiation changes can cause significant cytologic atypia in benign prostate glands that may mimic pagetoid spread of urothelial carcinoma. GATA3 is a common marker to differentiate prostatic adenocarcinoma from urothelial carcinoma. Read More

    Multicolor immunofluorescence reveals that p63- and/or K5-positive progenitor cells contribute to normal breast epithelium and usual ductal hyperplasia but not to low-grade intraepithelial neoplasia of the breast.
    Virchows Arch 2017 Mar 16. Epub 2017 Mar 16.
    Institute for Hematopathology, 22547, Hamburg, Germany.
    We contend that knowledge about the cellular composition of normal breast epithelium is a prerequisite for understanding proliferative breast disease. Against this background, we used multicolor immunofluorescence to study normal breast epithelium and two types of intraepithelial proliferative breast lesion for expression of the p63, basal keratin K5, glandular keratin K8/18, SMA, ER-alpha, and Ki67. We studied eight normal breast epithelium samples, 12 cases of usual ductal hyperplasia, and 33 cases of low-grade intraepithelial neoplasia (9 flat epithelial atypia, 14 low-grade ductal carcinoma in situ and 10 cases of lobular neoplasia). Read More

    Discovery of hedgehog antagonists for cancer therapy.
    Curr Med Chem 2017 Mar 16. Epub 2017 Mar 16.
    Department of Organic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700 032. India.
    Background: The evolutionarily conserved Hedgehog (Hh) signaling cascade is one of the key mediators of embryonic development of many metazoans. This pathway has been extensively targeted by small molecule inhibitors as its misregulation leads to various malignancies and developmental disorders. Thus, blocking this pathway can be a novel therapeutic avenue for the treatment of Hedgehog-dependent cancers. Read More

    Paramedian forehead flap combined with hinge flap for nasal tip reconstruction.
    An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):140-143
    Hospital Santa Casa de Curitiba - Curitiba (PR), Brazil.
    The paramedian forehead flap is a great option for restoration of complex nasal defects. For full-thickness defects, it may be used alone or in combination with other methods. We present a patient with a basal cell carcinoma on the distal nose treated by Mohs micrographic surgery, and a resulting full-thickness defect repaired with paramedian forehead flap combined with a hinge flap. Read More

    Porokeratosis of Mibelli in an HIV-positive patient.
    An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):131-133
    Hospital do Servidor Público Estadual de São Paulo (HSPE) - São Paulo (SP) - Brazil.
    Porokeratosis represents a group of disorders of epidermal keratinization that are characterized by one or more annular plaques surrounded by a histologically distinctive hyperkeratotic ridge-like border called the cornoid lamella. Many studies showed that organ transplantation and immunosuppression were associated in a significant number of cases. Furthermore, an association with squamous cell carcinoma and basal cell carcinoma has been noted in all variants of porokeratosis. Read More

    An Aggressive Microcystic Adnexal Carcinoma Infiltrating the Sternum.
    J Drugs Dermatol 2017 Feb;16(2):180-181
    Microcystic adnexal carcinoma is a rare cutaneous tumor that is often misdiagnosed and has the potential to be aggressive. Mohs surgery is the treatment of choice to prevent recurrences. We present a case of a large recurrent microcystic adnexal carcinoma on the sternum, initially diagnosed as a basal cell carcinoma. Read More

    Imiquimod 5% cream for the treatment of large nodular basal cell carcinoma at the medial canthal area.
    Indian J Ophthalmol 2017 Jan;65(1):48-51
    Department of Ophthalmology, Istanbul Beyoglu Eye Research and Training Hospital, Galata, 34421 Istanbul, Turkey.
    Context (Background): Imiquimod (IMQ) 5% cream is an immunomodulatory and antitumorigenic agent, which was used as a topical treatment regimen, who had periocular basal cell carcinoma (BCC).

    Aim: This study aims to present three cases with large BCC at the medial canthal area treated with IMQ 5% cream.

    Materials And Methods: IMQ 5% cream was used in three patients with ages 45, 49, and 73 who preferred medical treatment over surgery. Read More

    Orthovoltage X-rays for Postoperative Treatment of Resected Basal Cell Carcinoma in the Head and Neck Area.
    J Cutan Med Surg 2016 Dec 1:1203475416687268. Epub 2016 Dec 1.
    1 Netherlands Cancer Institute/Antoni Van Leeuwenhoek Hospital, Amsterdam, Netherlands.
    Background: Surgery is the golden standard for treating basal cell carcinomas. In case of positive tumor margins or recurrent disease, postoperative adjuvant or salvaging therapy is suggested to achieve good local control.

    Objective: To retrospectively report on local control and toxicity of postoperative radiotherapy by means of orthovoltage X-rays for residual or recurrent basal cell carcinoma after surgery in the head and neck area. Read More

    Vismodegib Therapy for Basal Cell Carcinoma in an 8-Year-Old Chinese Boy with Xeroderma Pigmentosum.
    Pediatr Dermatol 2017 Mar;34(2):163-165
    Nellis Air Force Base, Mike O'Callaghan Federal Medical Center, Las Vegas, Nevada.
    Vismodegib is an oral inhibitor of the Hedgehog signaling pathway and has been used to treat basal cell carcinoma (BCC) in adults. This article reports clearance of a nodular BCC of the nasal tip in an 8-year-old boy with xeroderma pigmentosum (XP). BCC can pose therapeutic challenges when located in areas that are not amenable to traditional therapies such as Mohs micrographic surgery or topical agents. Read More

    Bilateral Lymphatic Spread of Metastatic Basal Cell Carcinoma.
    Plast Reconstr Surg Glob Open 2016 Dec 23;4(12):e1182. Epub 2016 Dec 23.
    Department of Surgery, Division of Surgical Oncology, 987400 Nebraska Medical Center, University of Nebraska Medical Center, Omaha, Neb.
    Herein, we report a case of a patient with an abnormal skin lesion that remained unchecked by medical professionals for approximately 20 years. Upon physical examination in the emergency department for a fractured hip, an infiltrative mass was incidentally discovered. The neoplasm was noted to have progressed from an eraser-sized mass to a 3. Read More

    [The role of dermoscopy in the diagnosis of basosquamous carcinoma].
    Pan Afr Med J 2016 21;25:252. Epub 2016 Dec 21.
    Département d'Anatomo-pathologie, CHU Hassan II, Fès, Maroc.
    Basosquamous carcinoma (BSC) is a rare skin cancer which has areas of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) and a transition zone between them. However, dermoscopic features of BSC are not well described in the literature, except for two studies. The aim of this case study was to better identify and clarify the role of dermoscopy in the diagnosis of BSC, although histological confirmation is necessary. Read More

    Proteomic profiling of fetal esophageal epithelium, esophageal cancer, and tumor-adjacent esophageal epithelium and immunohistochemical characterization of a representative differential protein, PRX6.
    World J Gastroenterol 2017 Feb;23(8):1434-1442
    Jun-Hui Guo, Henan Province Hospital of TCM, Zhengzhou 450000, Henan Province, China.
    Aim: To understand the molecular mechanism of esophageal cancer development and provide molecular markers for screening high-risk populations and early diagnosis.

    Methods: Two-dimensional electrophoresis combined with mass spectrometry were adopted to screen differentially expressed proteins in nine cases of fetal esophageal epithelium, eight cases of esophageal cancer, and eight cases of tumor-adjacent normal esophageal epithelium collected from fetuses of different gestational age, or esophageal cancer patients from a high-risk area of esophageal cancer in China. Immunohistochemistry (avidin-biotin-horseradish peroxidase complex method) was used to detect the expression of peroxiredoxin (PRX)6 in 91 cases of esophageal cancer, tumor-adjacent normal esophageal tissue, basal cell hyperplasia, dysplasia, and carcinoma in situ, as well as 65 cases of esophageal epithelium from fetuses at a gestational age of 3-9 mo. Read More

    Pulsed CO2 Laser Ablation of Superficial Basal Cell of Limbs and Trunk: A Comparative Randomized Clinical Trial With Cryotherapy and Surgical Ablation.
    Dermatol Surg 2017 Mar 13. Epub 2017 Mar 13.
    *Dermatology Department, University of Brescia, Brescia, Italy; †Dermatology Unit, NorthShore University HealthSystem, Skokie, Illinois.
    Background: Pulsed CO2 laser is a treatment of superficial basal cell carcinoma (sBCC) although robust clinical evidence has not been reported so far.

    Objective: The authors investigated efficacy, safety, time to wound healing, cosmetic outcome, patient satisfaction, and cost-effectiveness ratio of pulsed CO2 laser in comparison to cryotherapy and surgery.

    Materials And Methods: BCCs of the trunk and extremities were randomized to one of the treatments. Read More

    Association between Cataract and Keratinocytic Skin Cancers or Melanoma: Speculating on the Common Role of Sun and Ultraviolet Radiation Exposures.
    Ophthalmic Epidemiol 2017 Mar 13:1-5. Epub 2017 Mar 13.
    b Sackler Faculty of Medicine , Tel Aviv University , Tel Aviv , Israel.
    Purpose: Cataract and sun-related skin conditions are proxies to lifetime UV exposure. We examined the association between them using real-world data from an unselected Israeli population.

    Methods: Computerized data was obtained from an Israeli health maintenance organization regarding cases of sun-related skin pathologies and cataract diagnosed between 2006 and 2011 in 686,260 members aged 40 or above. Read More

    Hedgehog Signaling: From Basic Biology to Cancer Therapy.
    Cell Chem Biol 2017 Mar 9;24(3):252-280. Epub 2017 Mar 9.
    State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:
    The Hedgehog (HH) signaling pathway was discovered originally as a key pathway in embryonic patterning and development. Since its discovery, it has become increasingly clear that the HH pathway also plays important roles in a multitude of cancers. Therefore, HH signaling has emerged as a therapeutic target of interest for cancer therapy. Read More

    Nonmelanoma skin cancer and risk of all-cause and cancer-related mortality: a systematic review.
    Arch Dermatol Res 2017 Mar 11. Epub 2017 Mar 11.
    Hollings Cancer Center, Medical University of South Carolina, 68 President Street, MSC 955, Charleston, SC, 29425, USA.
    Some reports suggest that a history of nonmelanoma skin cancer (NMSC) may be associated with increased mortality. NMSCs have very low fatality rates, but the high prevalence of NMSC elevates the importance of the possibility of associated subsequent mortality from other causes. The variable methods and findings of existing studies leave the significance of these results uncertain. Read More

    Identification of novel NF-ĸB transcriptional targets in TNFα-treated HeLa and HepG2 cells.
    Cell Biol Int 2017 Mar 8. Epub 2017 Mar 8.
    State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, China.
    Identification of target genes of NF-ĸB is critical for deeply understanding its biological functions. Here we identified five novel NF-ĸB target genes. Firstly, we found that 20 NF-ĸB potential target genes (PTGs) identified by ChIP-Seq and Genechip assay were enriched into the KEGG term of Pathways in cancer, 16 of them were enriched into the KEGG pathways of Small cell lung cancer, Chronic myeloid leukemia, Basal cell carcinoma, Pancreatic cancer, and Colorectal cancer. Read More

    Corrupted colonic crypt fission in carcinogen-treated rats.
    PLoS One 2017 8;12(3):e0172824. Epub 2017 Mar 8.
    Department of Pathology, Karolinska Institute and University Hospital, Stockholm, Sweden.
    Background: The colonic crypts in rats reproduce themselves by symmetric fission at the base of the crypts, and proceeding upwards, generate two separate identical crypts. Recently we reported corrupted colonic crypt fission (CCCF) in rats with colonic carcinoma. Here we investigated whether CCCF also occurred in the colonic mucosa without carcinoma in carcinogen-treated rats. Read More

    Integrin-β4 identifies cancer stem cell-enriched populations of partially mesenchymal carcinoma cells.
    Proc Natl Acad Sci U S A 2017 Mar 7;114(12):E2337-E2346. Epub 2017 Mar 7.
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142;
    Neoplastic cells within individual carcinomas often exhibit considerable phenotypic heterogeneity in their epithelial versus mesenchymal-like cell states. Because carcinoma cells with mesenchymal features are often more resistant to therapy and may serve as a source of relapse, we sought to determine whether such cells could be further stratified into functionally distinct subtypes. Indeed, we find that a basal epithelial marker, integrin-β4 (ITGB4), can be used to enable stratification of mesenchymal-like triple-negative breast cancer (TNBC) cells that differ from one another in their relative tumorigenic abilities. Read More

    Automated basal cell carcinoma detection in high-definition optical coherence tomography.
    Conf Proc IEEE Eng Med Biol Soc 2016 Aug;2016:2885-2888
    Basal cell carcinoma (BCC) is the most common non-melanoma skin cancer. Conventional diagnosis of BCC requires invasive biopsies. Recently, a high-definition optical coherence tomography (HD-OCT) technique has been developed, which provides a non-invasive in vivo imaging method of skin. Read More

    Smad3-dependent CCN2 mediates fibronectin expression in human skin dermal fibroblasts.
    PLoS One 2017 7;12(3):e0173191. Epub 2017 Mar 7.
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America.
    The potential involvement of connective tissue growth factor (CCN2/CTGF) in extracellular matrix (ECM) production is recognized. However, the role CCN2 in fibronectin (FN) gene expression has remained incompletely understood and even controversial. Here we report that CCN2 is absolutely necessary for FN expression in primary human skin dermal fibroblasts, the major cells responsible for ECM production in skin. Read More

    CD40 Ligand Is Increased in Mast Cells in Psoriasis and Actinic Keratosis but Less So in Epithelial Skin Carcinomas.
    Cancer Invest 2017 Mar 7;35(3):143-151. Epub 2017 Mar 7.
    a Department of Dermatology , Kuopio University Hospital and University of Eastern Finland , Kuopio , Finland.
    The expression of CD40 ligand (CD40L) in mast cells was investigated in biopsies from lesional and non-lesional skin samples of patients with psoriasis, actinic keratosis (AK), basal cell carcinoma, and squamous cell carcinoma using a sequential double-staining technique. The percentage of CD40L(+) mast cells was higher in the lesional than in the non-lesional skin (p < .003). Read More

    Differing tumor-suppressor functions of Arf and p53 in murine basal cell carcinoma initiation and progression.
    Oncogene 2017 Mar 6. Epub 2017 Mar 6.
    Children's Hospital Oakland Research Institute, Oakland, CA, USA.
    Human basal cell carcinomas (BCCs) very frequently carry p53 mutations, and p53 loss markedly accelerates murine BCC carcinogenesis. We report here our studies of the mechanism by which p53 is activated to suppress BCC carcinogenesis. We find that aberrant hedgehog signaling in microscopic BCCs activates p53 in part via Arf (that is, the oncogene-induced stress pathway) but not via the DNA damage response pathway. Read More

    The importance of patient-centred care to overcome barriers in the management of actinic keratosis.
    J Eur Acad Dermatol Venereol 2017 Mar;31 Suppl 2:17-20
    Department of Cutaneous Medicine & Surgery, The Royal London Hospital & QMUL, Bart's Health NHS Trust, Whitechapel, London, UK.
    Visible actinic keratosis (AK) lesions and subclinical (non-visible) sun damage in the field of cancerization are associated with risk of both non-melanoma skin cancer, including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), and, more rarely, melanoma. As the incidences of AK and skin cancer are increasing, effective prevention and treatment of AK is essential to minimize disease burden and improve patient quality of life. Currently, AK lesions are often left untreated and field therapies are underused. Read More

    Superficial basal cell carcinoma treated with 70% trichloroacetic acid applied topically: a case study.
    Clin Cosmet Investig Dermatol 2017 23;10:67-69. Epub 2017 Feb 23.
    Department of Pathology, University of Medicine and Pharmacy of Targu-Mures, Targu-Mures, Romania.
    Background: Basal cell carcinoma (BCC) is the most common form of skin cancer, affecting millions of people worldwide. The treatment concept for BCCs is the surgical one, but it is costly, as such, searching for alternative medical therapeutics is justified.

    Aim: To highlight the efficacy of high concentration (70%) trichloroacetic acid (TCA) as a choice therapy for low-risk BCC. Read More

    Nonmelanoma Skin Cancers After Kidney Transplant: Our 15 Years of Experience With Mammalian Target of Rapamycin Inhibitors.
    Exp Clin Transplant 2017 Feb;15(Suppl 1):236-239
    Department of General Surgery, Izmir Bozyaka Education and Research Hospital, Izmir, Turkey.
    Objectives: We evaluated patients with nonmelanoma skin cancer after kidney transplant and the effects of immunosuppression reduction and switching to a mammalian target of rapamycin inhibitor drugs.

    Materials And Methods: Kidney transplant recipients were evaluated retrospectively from patient medical records (between January 2000 and December 2014). A 30% increase in serum creatinine was accepted as indicating renal failure progression. Read More

    Notch signaling is significantly suppressed in basal cell carcinomas and activation induces basal cell carcinoma cell apoptosis.
    Mol Med Rep 2017 Feb 2. Epub 2017 Feb 2.
    Department of Dermatology and Skin Science, University of British Columbia, Vancouver, BC V5Z 4E8, Canada.
    A subset of basal cell carcinomas (BCCs) are directly derived from hair follicles (HFs). In some respects, HFs can be defined as 'ordered' skin appendage growths, while BCCs can be regarded as 'disordered' skin appendage growths. The aim of the present study was to examine HFs and BCCs to define the expression of common and unique signaling pathways in each skin appendage. Read More

    Association Between Programmed Death Ligand 1 Expression in Patients With Basal Cell Carcinomas and the Number of Treatment Modalities.
    JAMA Dermatol 2017 Mar 4. Epub 2017 Mar 4.
    Department of Dermatology, Stanford University School of Medicine, Redwood City, California.
    Importance: Response to programmed death 1 (PD-1) inhibitors has been associated with programmed death ligand 1 (PD-L1) expression levels in several cancers, but PD-L1 expression and its clinical significance in basal cell carcinoma (BCC) are unknown to date.

    Objective: To assess PD-L1 expression in treatment-naive and treated BCCs.

    Design, Setting, And Participants: This investigation was a cross-sectional study at a single academic tertiary referral center. Read More

    A Quantitative Study of In Vivo Protoporphyrin IX Fluorescence Build Up During Occlusive Treatment Phases.
    Photodiagnosis Photodyn Ther 2017 Feb 28. Epub 2017 Feb 28.
    Photobiology Unit, Ninewells Hospital and Medical School, UK. Electronic address:
    Background: Topical photodynamic therapy (PDT) is a non-invasive light based therapy used to treat non-melanoma skin cancer (NMSC) and dysplasia. During PDT, the light sensitive molecule protoporphyrin IX (PpIX) is activated, resulting in the production of singlet oxygen, which subsequently leads to cell death. PpIX is metabolised from a topically applied pro-drug and the strong fluorescence signal associated with PpIX can be utilised as an indicator of the amount of PpIX present within the tumour tissue. Read More

    Granular cell differentiation: A review of the published work.
    J Dermatol 2017 Mar;44(3):251-258
    Boston University School of Medicine, Boston, Massachusetts, USA.
    Since the initial description of the granular cell tumor in 1926, numerous other neoplasms, both benign and malignant, have been described to exhibit granular cell change. In most cases, diagnosis remains straightforward via recognition of retained histopathological morphology of the archetypal tumor, despite the presence of focal granular appearance. However, tumors with granular cell differentiation can present a diagnostic challenge either by mimicking alternative diagnoses, or by failing to exhibit architectural clues of the primary entity, thus requiring an immunohistochemical work-up. Read More

    Long Term Incidence of Secondary Malignancies Following Allogeneic Hematopoietic Cell Transplantation: a Single Center Experience.
    Biol Blood Marrow Transplant 2017 Feb 27. Epub 2017 Feb 27.
    Allogeneic Blood and Marrow Transplant Program, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Canada.
    To review the emergence of secondary malignancies (SM) in recipients of allogeneic hematopoietic cell transplantation (HCT). We documented the occurrence of SM in 2415 allogeneic HCT recipients, ages 18-71, in a single center over four decades. SM was seen in 209 patients, including 58 with non-metastatic squamous cell (SCC) and basal cell carcinoma (BCC) of the skin. Read More

    Cutaneous Neoplasms in Myotonic Dystrophy Type 1.
    Dermatology 2017 Mar 2. Epub 2017 Mar 2.
    Background: The most frequent skin features associated with myotonic dystrophy type 1 (DM1) are frontal alopecia and pilomatrixomas. Several reports suggest that the incidence of basal cell carcinoma is increased in DM1. However, two recently published studies examining this topic have contradictory results. Read More

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