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    IRE1α links Nck1 deficiency to attenuated PTP1B expression in HepG2 cells.
    Cell Signal 2017 Apr 25. Epub 2017 Apr 25.
    Department of Medicine, McGill University, Montreal, QC H4A 3J1, Canada; The Research Institute of McGill University Health Centre, Montreal, QC H4A 3J1, Canada. Electronic address:
    PTP1B, a prototype of the non-receptor subfamily of the protein tyrosine phosphatase superfamily, plays a key role in regulating intracellular signaling from various receptor and non-receptor protein tyrosine kinases. Previously, we reported that silencing Nck1 in human hepatocellular carcinoma HepG2 cells enhances basal and growth factor-induced activation of the PI3K-Akt pathway through attenuating PTP1B expression. However, the underlying mechanism by which Nck1 depletion represses PTP1B expression remains unclear. Read More

    Cytokeratin 17 and Ki-67: Immunohistochemical markers for the differential diagnosis of keratoacanthoma and squamous cell carcinoma.
    Oncol Lett 2017 Apr 1;13(4):2539-2548. Epub 2017 Mar 1.
    Department of Pathology, Istanbul Education and Research Hospital, Istanbul 34098, Turkey.
    The clinical and histopathological distinction between keratoacanthoma (KA) and squamous cell carcinoma (SCC) is essential, but frequently difficult to make. The utility of CK17 and Ki-67 expression in distinguishing between KA and SCC was investigated. Immunohistochemical staining patterns for CK17 and Ki-67 were evaluated in 24 KA and 27 SCC cases. Read More

    Georgian Med News 2017 Feb(263):7-10
    Academic Teaching Hospital Dresden-Friedrichstadt, Department of Dermatology and Allergology; Institute of Pathology "Georg Schmorl"; Dresden, Germany; Medical Institute of Ministry of Interior (MVR), Department of Dermatology and Dermatologic Surgery, Sofia, Bulgaria.
    Non-melanoma skin cancer incidence is rising worldwide. The leading neoplasias are basal cell carcinoma and squamous cell carcinoma. We report on an 88-year-old female patient with a rapidly grown, symptomless, exophytic tumor of the supraclavicular area. Read More

    Sporadic versus syndromic keratocysts - Can we predict treatment outcome? A review of 102 cysts.
    Oral Dis 2017 Apr 27. Epub 2017 Apr 27.
    Department of Oral and Maxillofacial Surgery, the Clinical Research Institute and the Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
    Objectives: Keratocystic odontogenic tumor (KCOT) demonstrates variable growth mechanisms and biologic behavior, partly due to origin and histology. We looked for the most contributing factors in predicting outcome of treatment.

    Subjects And Methods: We retrospectively reviewed 118 medical files of patients diagnosed with KCOT (by tissue biopsy before surgical treatment) with/without nevoid basal cell carcinoma syndrome (NBCCS) from 1995 to 2015. Read More

    Isolation of antioxidant phenolics from Schinopsis brasiliensis based on a preliminary LC-MS profiling.
    Phytochemistry 2017 Apr 24;140:45-51. Epub 2017 Apr 24.
    Dipartimento di Farmacia, Università degli Studi di Salerno, via Giovanni Paolo II n. 132, 84084, Fisciano, SA, Italy. Electronic address:
    The phenolic content of the ethanol extract of the stem bark of the Brazilian plant Schinopsis brasiliensis Engl. (Anacardiaceae) has been evaluated together with the antioxidant activity. The good antioxidant activity exhibited in the Trolox Equivalent Antioxidant Capacity (TEAC) assay (TEAC value = 3. Read More

    Surgical Techniques for Closure of a Scalp Defect After Resection of Skin Malignancy.
    Dermatol Surg 2017 Apr 12. Epub 2017 Apr 12.
    *All authors are affiliated with the Department of Head and Neck Cancer, Maria Skłodowska Curie Memorial Cancer Centre and Institute of Oncology, Warsaw, Poland.
    Background: Surgery for scalp malignancies is aimed at the complete resection and a good aesthetic outcome. The goal was to develop an algorithm for scalp reconstruction based on the authors' surgical experience.

    Methods: This is a retrospective analysis of 123 procedures of scalp malignancies in 105 patients. Read More

    Dermoscopy-pathology relationship in seborrheic keratosis.
    J Dermatol 2017 May;44(5):518-524
    Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan.
    Making a definitive diagnosis of seborrheic keratosis (SK) can be challenging for the naked eye due to its wide variation in clinical features. Fortunately, however, most cases of SK exhibit the typical dermoscopic findings of fissures and ridges, hairpin vessels with white halo, comedo-like openings, and milia-like cysts, all of which are helpful to distinguish SK from melanoma, melanocytic nevus, squamous cell carcinoma, basal cell carcinoma (BCC) and other skin tumors. Histopathologically, these dermoscopic characteristics correspond to papillomatous surface of the epidermis, enlarged capillaries of the dermal papillae, pseudohorn cysts in the epidermis opened to the surface of the lesion and intraepidermal cysts, respectively. Read More

    Trichoscopic Patterns in Squamous Cell Carcinoma: : A Case Report.
    Int J Trichology 2016 Oct-Dec;8(4):191-194
    Department of Pathology, S Nijalingappa Medical College, Bagalkot, Karnataka, India.
    Squamous cell carcinoma (SCC) is the second most cutaneous malignancy after basal cell carcinoma (BCC) with increasing incidence. In the view its nodular manifestation; it can appear similar to nodular BCC, atypical fibroxanthoma, sclerosing liposarcoma and desmoplastic melanoma. Prognostic and therapeutic implications are different in all these conditions and thus their distinction becomes important. Read More

    Photodynamic therapy in the management of basal cell carcinoma: Retrospective evaluation of outcome.
    Photodiagnosis Photodyn Ther 2017 Apr 22. Epub 2017 Apr 22.
    UCL Department of Surgery, London, UK; UCLH Head and Neck Centre, London, UK; Unit of Oral and Maxillofacial Surgery, UCL Eastman Dental Institute, London, UK.
    Introduction: Photodynamic therapy (PDT) is a relatively new method of treating various kinds of pathologies. In this retrospective study, a total of 148 patients with basal cell carcinoma (BCC) were treated with surface illumination methyl aminolevulinate - photodynamic therapy (MAL-PDT) or meta-tetrahydroxyphenylchlorin (mTHPC-PDT). Comparisons with the clinical features, rate of recurrence and overall outcome were made. Read More

    Surgical Techniques for Closure of a Scalp Defect After Resection of Skin Malignancy.
    Dermatol Surg 2017 May;43(5):715-723
    *All authors are affiliated with the Department of Head and Neck Cancer, Maria Skłodowska Curie Memorial Cancer Centre and Institute of Oncology, Warsaw, Poland.
    Background: Surgery for scalp malignancies is aimed at the complete resection and a good aesthetic outcome. The goal was to develop an algorithm for scalp reconstruction based on the authors' surgical experience.

    Methods: This is a retrospective analysis of 123 procedures of scalp malignancies in 105 patients. Read More

    Heterogeneity in esophageal and gastric cardia precursor progression during six-year endoscopic surveillance after population-based screening in a Chinese high-risk region.
    Thorac Cancer 2017 Apr 25. Epub 2017 Apr 25.
    Cancer Center, Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
    Background: The study was conducted to examine esophageal and gastric cardia precursor progression.

    Methods: After population-based baseline screening, 145 precursor and 335 chronic inflammation cases were endoscopically surveyed for six years.

    Results: Surveillance of interval and baseline diagnoses for 18 severe dysplasia (SD) cases later detected were: 13, 23, 39, and 44 months since a diagnosis of chronic inflammation in four cases; 6, 6, 6, 11, 13, 16, 16, and 23 months since mild dysplasia (mD) diagnoses in eight; and 6, 9, 10, 13, 18, and 48 months since moderate dysplasia (MD) diagnoses in six. Read More

    Eyelid reconstruction using the "Hughes" tarsoconjunctival advancement flap: Long-term outcomes in 122 consecutive cases over a 13-year period.
    Orbit 2017 Apr 24:1-6. Epub 2017 Apr 24.
    a Department of Ophthalmology , Waikato District Health Board , Hamilton , New Zealand.
    This article evaluates the complications and long term functional and cosmetic outcomes of tarsoconjunctival advancement flaps for repairing a range of lower eyelid defects in a large cohort of consecutive cases. A retrospective series of 122 consecutive cases of eyelid reconstruction using tarsoconjunctival-advancement flaps was conducted at Waikato Hospital, or Hamilton Eye Clinic, New Zealand. All cases of lid reconstruction using tarsoconjunctival-advancement flaps between January 1, 2001 until April 3, 2014 were included for analysis. Read More

    Antimicrobial and anticancer photodynamic activity of a phthalocyanine photosensitizer with N-methyl morpholiniumethoxy substituents in non-peripheral positions.
    J Inorg Biochem 2017 Apr 8;172:67-79. Epub 2017 Apr 8.
    Department of Chemical Technology of Drugs, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznan, Poland. Electronic address:
    Photodynamic therapy involves the use of a photosensitizer that is irradiated with visible light in the presence of oxygen, resulting in the formation of reactive oxygen species. A novel phthalocyanine derivative, the quaternary iodide salt of magnesium(II) phthalocyanine with N-methyl morpholiniumethoxy substituents, was synthesized, and characterized. The techniques used included mass spectrometry (MALDI TOF), UV-vis, NMR spectroscopy, and photocytotoxicity against bacteria, fungi and cancer cells. Read More

    Nonsurgical Therapies for Basal Cell Carcinoma: A Review.
    Actas Dermosifiliogr 2017 Apr 19. Epub 2017 Apr 19.
    Servicio de Dermatología, Hospital San José, Fundación Universitaria de Ciencias de la Salud, FUCS, Bogotá, Colombia.
    Basal cell carcinoma (BCC) is the most prevalent malignant tumor in humans and the local destruction of tissue that can result from excision has a significant impact on well-being. Treating BCC is costly for health care systems given the high incidence of this tumor, especially in older patients. Standard treatment involves either resection with histologic assessment of margins or Mohs micrographic surgery. Read More

    Diagnostic and prognostic value of long noncoding RNAs as biomarkers in urothelial carcinoma.
    PLoS One 2017 21;12(4):e0176287. Epub 2017 Apr 21.
    Department of Urology, Medical Faculty, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany.
    Many long noncoding RNAs (lncRNAs) are deregulated in cancer and contribute to oncogenesis. In urothelial carcinoma (UC), several lncRNAs have been reported to be overexpressed and proposed as biomarkers. As most reports have not been confirmed independently in large tissue sets, we aimed to validate the diagnostic and prognostic value of lncRNA upregulation in independent cohorts of UC patients. Read More

    Increased expression of uPA, uPAR, and PAI-1 in psoriatic skin and in basal cell carcinomas.
    Arch Dermatol Res 2017 Apr 20. Epub 2017 Apr 20.
    Lomonosov Moscow State University, 31-5, Lomonosovsky av., Moscow, 119192, Russia.
    There is substantial evidence implicating the urokinase system in tissue remodeling during neo-vascularization, inflammation, tumor invasion, and metastasis. Regulated degradation of the extracellular matrix at the leading edge of migrating cells, mediated by uPA and uPAR, is required for tissue remodeling, invasiveness, and angiogenesis. Psoriasis and basal cell carcinoma (BCC) are the most common skin diseases. Read More

    Recent advances in genitourinary tumors: A review focused on biology and systemic treatment.
    Crit Rev Oncol Hematol 2017 May 14;113:171-190. Epub 2017 Mar 14.
    Vall d'Hebron University Hospital and Institute of Oncology, Universitat Autònoma de Barcelona, Barcelona, Spain. Electronic address:
    Updated information published up to 2016 regarding major advances in renal cancer, bladder cancer, and prostate cancer is here presented. Based on an ever better understanding of the genetic and molecular alterations that govern the initial pathogenic mechanisms of tumor oncogenesis, an improvement in the characterization and treatment of urologic tumors has been achieved in the past year. According to the Cancer Genome Atlas (ATLAS) project, alterations in the MET pathway are characteristics of type 1 papillary renal cell carcinomas, and activation of NRF2-ARE pathway is associated with the biologically distinct type 2. Read More

    c-MYC-Making Liver Sick: Role of c-MYC in Hepatic Cell Function, Homeostasis and Disease.
    Genes (Basel) 2017 Apr 19;8(4). Epub 2017 Apr 19.
    Department of Internal Medicine III, University Hospital RWTH, Aachen 52074, Germany.
    Over 35 years ago, c-MYC, a highly pleiotropic transcription factor that regulates hepatic cell function, was identified. In recent years, a considerable increment in the number of publications has significantly shifted the way that the c-MYC function is perceived. Overexpression of c-MYC alters a wide range of roles including cell proliferation, growth, metabolism, DNA replication, cell cycle progression, cell adhesion and differentiation. Read More

    The epidemic spreading of basal cell carcinoma: incidence trend, demographic features, characteristics and risk factors in a retrospective study of 8557 lesions in Bologna.
    G Ital Dermatol Venereol 2017 Apr 19. Epub 2017 Apr 19.
    Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, St. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
    Background: Basal cell carcinoma (BCC) has a rising incidence worldwide. The aim was to evaluate incidence trend, demographic features and risk factors for BCC in the area of Bologna in northern-central Italy.

    Methods: All the consecutive histopathologically diagnosed BCCs at the Dermatology of the Bologna University from 1990 to 2014 were retrospectively reviewed. Read More

    Multi-factorial modulation of colorectal carcinoma cells motility - partial coordination by the tetraspanin Co-029/tspan8.
    Oncotarget 2017 Apr 16:27454-27470. Epub 2017 Apr 16.
    Inserm, UMR-S 935, SFR André Lwoff, Villejuif, France.
    Colorectal carcinoma cells Isreco1 display an ability to migrate controlled by a complex set of signals issued from the membrane. By comparing cells infected by mycoplasmas and mycoplasmas free cells, we have established that basal 2D migration is dependent on a double signal mediated by the collagen receptors integrins alpha1/2 and the Toll-Like receptor TLR2. The signal issued from mycoplasmas can be replaced by a TLR2 ligand and the functional effect is neutralized by silencing of MyD88. Read More

    GD2 expression in breast cancer.
    Oncotarget 2017 Mar 18. Epub 2017 Mar 18.
    Department of Medical and Surgical Sciences for Children and Adults, University-Hospital of Modena and Reggio Emilia, 71-41124 Modena, Italy.
    Breast cancer (BC) is a heterogeneous disease, including different subtypes having diverse incidence, drug-sensitivity and survival rates. In particular, claudin-low and basal-like BC have mesenchymal features with a dismal prognosis. Disialoganglioside GD2 is a typical neuroectodermal antigen expressed in a variety of cancers. Read More

    Non-melanoma skin cancer: new and future synthetic drug treatments.
    Expert Opin Pharmacother 2017 May 17;18(7):689-699. Epub 2017 Apr 17.
    a Center for Dermatooncology, Department of Dermatology , University Hospital Tübingen , Tübingen , Germany.
    Introduction: Non-melanoma skin cancers (NMSC) mainly comprise two different entities: basal cell carcinoma (BCC) and squamous cell carcinoma (SCC); beneath these two entities, Merkel cell carcinoma, adnexal tumors, dermatofibrosarcoma protuberans, angiosarcoma, and cutaneous lymphoma belong to NMSC. These rare skin tumors are not the topic of this review. BCC and SCC are the most common cancers diagnosed in humans. Read More

    Semi-automated localization of dermal epidermal junction in optical coherence tomography images of skin.
    Appl Opt 2017 Apr;56(11):3116-3121
    Identifying the location of the dermal epidermal junction (DEJ) in skin images is essential in several clinical applications of dermatology such as epidermal thickness determination in healthy versus unhealthy skins, such as basal cell carcinoma. Optical coherence tomography (OCT) facilitates the visual detection of DEJ in vivo. However, due to the granular texture of speckle and a low contrast between dermis and epidermis, a skin border detection method is required for DEJ localization. Read More

    Cytokeratin 5/6 expression, prognosis and association with ER-α in high-grade serous ovarian carcinoma.
    Hum Pathol 2017 Apr 13. Epub 2017 Apr 13.
    Institute of Pathology, Charité University Hospital, Berlin, Germany; Tumor Bank Ovarian Cancer Network (TOC), Berlin, Germany.
    High-grade serous ovarian carcinoma remains one of the most lethal malignancies in females. For histopathological differentiation from mesothelioma cytokeratin, 5/6 immunohistochemistry is widely used. Another preferred marker for differential diagnosis to mesothelioma is ER-α. Read More

    Cigarette smoking and the risks of basal cell carcinoma and squamous cell carcinoma.
    J Invest Dermatol 2017 Apr 13. Epub 2017 Apr 13.
    Department of Population Health, QIMR Berghofer Medical Research Institute, Queensland, Australia; School of Public Health, University of Queensland, Queensland, Australia. Electronic address:
    Sunlight is the principal environmental risk factor for keratinocyte cancers, but other carcinogens have also been implicated, including tobacco smoke. Findings have been conflicting however. We investigated associations between cigarette smoking and incidence of BCC or SCC in QSkin, a prospective study of skin cancer (n=43,794). Read More

    SLC2A1/GLUT1 expression in mural nodules of intraductal papillary mucinous neoplasm of the pancreas.
    Hum Pathol 2017 Apr 12. Epub 2017 Apr 12.
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
    In intraductal papillary mucinous neoplasms (IPMNs), the presence of a mural nodule showing a papillary or nodular proliferation of tumor cells in the dilated pancreatic duct is an indication for resection of the IPMN. Solute carrier family 2, facilitated glucose transporter member 1, known as Glucose transporter type 1 (SLC2A1/GLUT1) mediates cellular glucose uptake in many carcinomas and is correlated with increased 18F-fluorodeoxyglucose ((18)F-FDG) uptake. We examined SLC2A1/GLUT1 expression in the mural nodules of 180 IPMN specimens to distinguish malignant/benign tumors. Read More

    Cost-Effectiveness Analysis of a Skin Awareness Intervention for Early Detection of Skin Cancer Targeting Men Older Than 50 Years.
    Value Health 2017 Apr 15;20(4):593-601. Epub 2017 Feb 15.
    NHMRC Centre for Research Excellence in Sun and Health, Queensland University of Technology, Kelvin Grove, Queensland, Australia; School of Public Health, Queensland University of Technology, Kelvin Grove, Queensland, Australia.
    Objectives: To assess the cost-effectiveness of an educational intervention encouraging self-skin examinations for early detection of skin cancers among men older than 50 years.

    Methods: A lifetime Markov model was constructed to combine data from the Skin Awareness Trial and other published sources. The model incorporated a health system perspective and the cost and health outcomes for melanoma, squamous and basal cell carcinomas, and benign skin lesions. Read More

    Multistep Approach for Improved Aesthetic and Functional Outcomes for Lower Extremity Wound Closure After Mohs Micrographic Surgery.
    Dermatol Surg 2017 May;43(5):704-707
    *Department of Plastic Surgery, Rhode Island Hospital and Warren Alpert Medical School, Brown University, Providence, Rhode Island; †Skinpros, LLC, Providence, Rhode Island; ‡Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, Rhode Island.
    Background: Lower extremity wounds present a major clinical challenge.

    Objective: This paper introduces a new multistep approach for improved aesthetic and functional outcome for lower extremity wound closure after Mohs micrographic surgery.

    Patients And Methods: In this prospective case series, 12 consecutive patients undergoing Mohs micrographic surgery for cutaneous malignancies of the lower extremities underwent closure assisted by elastic bandages, proper positioning with 45° flexion of the knee, buried vertical mattress sutures, and careful eversion, using a premium angled stapler. Read More

    Implementation of Systemic Hedgehog Inhibitors in Daily Practice as Neoadjuvant Therapy.
    J Natl Compr Canc Netw 2017 Apr;15(4):537-543
    From Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, and Comprehensive Skin Cancer Center, Icahn School of Medicine at Mount Sinai and Mount Sinai Beth Israel Medical Center, New York, New York.
    The most common cancer in both men and women is basal cell carcinoma (BCC). Although most primary and recurrent BCCs have high cure rates with standard therapies, advanced BCCs present a greater treatment challenge, especially in cosmetically and functionally sensitive areas. In patients unable to undergo surgery or radiation therapy, hedgehog inhibitors can be used neoadjuvantly to reduce tumor size, decreasing the extent and complexity of any subsequent surgery and providing either a cure or palliation. Read More

    Basal cell carcinoma: CD56 and Cytokeratin 5/6 Staining Patterns in the Differential Diagnosis with Merkel cell carcinoma.
    J Cutan Pathol 2017 Apr 12. Epub 2017 Apr 12.
    Dermatopathology Division, Department of Dermatology, Yale School of Medicine, New Haven, Connecticut.
    Background: Basal cell carcinoma (BCC) can resemble Merkel cell carcinoma (MCC) on histopathological examination and while CK20 is a useful marker in this differential, it is occasionally negative in MCC. CD56, a sensitive marker of neuroendocrine differentiation, is sometimes used to identify MCC, but has been reportedly variably positive in BCC as well. In contrast, CK5/6 consistently labels BCC but is not expressed in neuroendocrine tumors. Read More

    Melanoma and basal cell carcinoma in the hereditary leiomyomatosis and renal cell cancer syndrome. An expansion of the oncologic spectrum.
    J Dermatol Case Rep 2016 Nov 30;10(3):53-55. Epub 2016 Nov 30.
    Division of Dermatology, Cooper Medical School of Rowan University, Camden, New Jersey, USA.
    Background: Hereditary leiomyomatosis and renal cell cancer syndrome (HLRCC) is an autosomal dominant syndrome due to mutation in fumarate hydratase. Patients with HLRCC frequently develop cutaneous and uterine leiomyomata and are at risk for renal cell carcinoma. Rarely, other malignancies have been reported. Read More

    What's New in Eyelid Tumors.
    Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):143-152
    Department of Ophthalmology, SUNY Downstate Medical Center, Brooklyn, NY.
    Eyelid malignancies represent between 5% and 10% of all skin cancers. Basal cell carcinoma is the most common, followed by squamous cell carcinoma, sebaceous cell carcinoma, Merkel cell carcinoma, and melanoma. The gold standard treatment for periocular epithelial malignancies is surgical excision. Read More

    Decreased levels of baseline and drug-induced tubulin polymerisation are hallmarks of resistance to taxanes in ovarian cancer cells and are associated with epithelial-to-mesenchymal transition.
    Br J Cancer 2017 Apr 11. Epub 2017 Apr 11.
    Department of Medicine (Oncology), Stanford University School of Medicine, Stanford, CA 94305, USA.
    Background: ABCB1 expression is uncommon in ovarian cancers in the clinical setting so we investigated non-MDR mechanisms of resistance to taxanes.

    Methods: We established eight taxane-resistant variants from the human ovarian carcinoma cell lines A2780/1A9, ES-2, MES-OV and OVCAR-3 by selection with paclitaxel or docetaxel, with counter-selection by the transport inhibitor valspodar.

    Results: Non-MDR taxane resistance was associated with reduced intracellular taxane content compared to parental controls, and cross-resistance to other microtubule stabilising drugs. Read More

    [Mohs surgery for basal cell carcinoma].
    Ugeskr Laeger 2017 Feb;179(6)
    Micrographic surgery is currently the only technique which ensures complete removal of basal cell carcinomas. The major limitation is the high set-up cost, which is particularly connected with specialized training of surgeons, technicians and the set-up of a histology facility for frozen tissue sectioning and staining. In the long run, however, the cost of Mohs surgery per patient does not exceed that of conventional surgery. Read More

    Paul of Aegina (ca 625-690 AD): an early description of a rare basal cell carcinoma of the breast.
    Clin Case Rep 2017 Apr 6;5(4):545-546. Epub 2017 Mar 6.
    Department of Anatomy & History of Medicine Faculty of Medicine University of Thessaly Viopolis P.O. 41500 Larissa Greece.
    Basal cell carcinoma of the breast is a rare type of skin cancer. A probable case reported c.650AD is described with very similar localized symptoms. Read More

    Burden and treatment patterns of advanced basal cell carcinoma among commercially insured patients in a United States database from 2010 to 2014.
    J Am Acad Dermatol 2017 Apr 6. Epub 2017 Apr 6.
    Novartis Pharmaceuticals Corporation, East Hanover, New Jersey.
    Background: The burden of advanced basal cell carcinoma (aBCC) is not fully understood.

    Objective: To compare BCC disease burden and treatment patterns for aBCC with those for non-aBCC.

    Methods: A retrospective, insurance claims-based study design was used. Read More

    One-stop-shop with confocal microscopy imaging versus standard care for surgical treatment of basal cell carcinoma: an open label, non-inferiority, randomized controlled multicenter trial.
    Br J Dermatol 2017 Apr 9. Epub 2017 Apr 9.
    Academic Medical Center, Department of Dermatology, Amsterdam, The Netherlands.
    Background: Routine punch biopsies are considered as the standard care to diagnose and subtype basal cell carcinoma (BCC) when clinically suspected.

    Objectives: We assessed the efficacy of a one-stop-shop concept using in vivo reflectance confocal microscopy imaging (RCM) as diagnostic tool versus standard care for surgical treatment in patients with clinically suspected BCC.

    Methods: In this open-label, parallel-group, non-inferiority, randomized controlled multicenter trial we enrolled patients with clinically suspected BCC at two tertiary referral centers in Amsterdam, the Netherlands. Read More

    Cutaneous basal cell carcinoma with distant metastasis to thorax and bone : A clinicopathological and immunohistochemical study of 15 cases.
    Virchows Arch 2017 Apr 8. Epub 2017 Apr 8.
    Department of Pathology, MD Anderson Cancer Center, Houston, TX, 77030, USA.
    Basal cell carcinoma (BCC) is the most common cutaneous malignancy and is characterized by a high cure rate after local excision. Metastatic BCC (mBCC) is an exceedingly rare event, associated with poor prognosis. We report clinicopathological and immunohistochemical features of 15 mBCC metastatic to the thorax and bone. Read More

    Restore the brake on tumor progression.
    Biochem Pharmacol 2017 Apr 5. Epub 2017 Apr 5.
    Cancer Biology Program, Fox Chase Cancer Center, Temple University Health System, Philadelphia, PA 19111, USA; Laboratory of Molecular Neuropathology, College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215021, China. Electronic address:
    Sonic hedgehog (Shh) signaling plays a key role in regulation of normal development. The negative feedback mechanism mediated by the transcriptional factor, Gli3, acts to finely tune Shh signaling, providing tight control of normal developmental processes. Hyperactivation of Shh signaling often leads to many human malignancies, including basal cell carcinoma and medulloblastoma (MB). Read More

    [Why is it important to differentiate trichoblastic carcinomas (CT) from basal cell carcinomas (CBC). About 21 cases].
    Ann Chir Plast Esthet 2017 Apr 3. Epub 2017 Apr 3.
    Service de chirurgie plastique, reconstructrice et esthétique, hôpitaux universitaire de Strasbourg, 67000 Strasbourg, France.
    Trichoblastic carcinoma is a rare epithelial malignant epithelial tumor, its diagnosis is difficult and the therapeutic management is non-consensual. This retrospective study, carried out between 2009 and 2015, covered 21 cases and analyzed the diagnostic and therapeutic characteristics of trichoblastic carcinomas. Sex ratio is 2. Read More

    Down-regulation of cytochrome P450 2C8 by 3-methylcholanthrene in human hepatocellular carcinoma cell lines.
    Can J Physiol Pharmacol 2017 Apr 6. Epub 2017 Apr 6.
    University of Toronto, Pharmacology and Toxicology, Toronto, Ontario, Canada ;
    The marked induction of cytochromes P450 such as CYP1A1 caused by polycyclic aromatic hydrocarbons (PAHs) like 3-methylcholanthrene (MC) is often accompanied by suppression of other hepatic P450s. The molecular mechanisms, functional consequences, and human relevance of P450 down-regulation by PAHs are poorly understood. MC suppresses mRNA levels for CYP2C8, an important human P450, in cultured human hepatocytes. Read More

    Secretory breast carcinoma with a papillary predominant pattern- an uncommon morphology variant.
    Histopathology 2017 Apr 6. Epub 2017 Apr 6.
    Department of Pathology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, PR China.
    Aims: Secretory breast carcinoma is a rare, low-grade, translocation-associated invasive carcinoma with unique morphology and excellent prognosis. Three patterns (microcystic, tubular, solid) have often been described in secretory carcinoma. Herein, we reported one case of secretory breast carcinoma with uncommon papillary predominant growth pattern. Read More

    Training a cell-level classifier for detecting basal-cell carcinoma by combining human visual attention maps with low-level handcrafted features.
    J Med Imaging (Bellingham) 2017 Apr 11;4(2):021105. Epub 2017 Mar 11.
    Universidad Nacional de Colombia , Computer Imaging and Medical Applications Lab, Department of Medical Imaging, Bogota, Colombia.
    Computational histomorphometric approaches typically use low-level image features for building machine learning classifiers. However, these approaches usually ignore high-level expert knowledge. A computational model (M_im) combines low-, mid-, and high-level image information to predict the likelihood of cancer in whole slide images. Read More

    Caspase 12 degrades IkBa protein and enhances MMP-9 expression in human nasopharyngeal carcinoma cell invasion.
    Oncotarget 2017 Mar 23. Epub 2017 Mar 23.
    Department of Otolaryngology, Head and Neck Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
    Caspase-12 (Casp12), an inflammatory caspase, functions as a dominant-negative regulator of inflammatory responses and is associated with the signaling of apoptosis. However, the physiological function of Casp12 presented in cancer cells is still unclear. This study demonstrated that overexpression of Casp12 mediated IκBα degradation and significantly increased NF-κB activity. Read More

    Spectrum of immune-related conditions associated with risk of keratinocyte cancers among elderly adults in the United States.
    Cancer Epidemiol Biomarkers Prev 2017 Apr 4. Epub 2017 Apr 4.
    Division of Cancer Epidemiology and Genetics, National Cancer Institute.
    Elevated keratinocyte carcinoma (KC) risk is present with several immune-related conditions, e.g., solid organ transplantation and non-Hodgkin lymphoma. Read More

    History of Keratinocyte Carcinoma and Risk of Melanoma: A Prospective Cohort Study.
    J Natl Cancer Inst 2017 Apr;109(4)
    Affiliations of authors: Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing, China (SW); Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA (SW); Department of Dermatology, Warren Alpert Medical School (EC, WQL, AAQ), and Department of Epidemiology, School of Public Health (EC, WQL, AAQ), Brown University, Providence, RI; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (EC, AAQ); Department of Dermatology, Rhode Island Hospital, Providence, RI (AAQ).
    Background: The association between history of keratinocyte carcinoma (KC, also known as nonmelanoma skin cancer) and risk of developing invasive melanoma has not been assessed comprehensively using prospective data.

    Methods: We followed 91 846 women in the Nurses' Health Study (NHS; 1984-2010), 114 918 women in the NHSII (1989-2011), and 48 946 men in the Health Professionals Follow-up Study (1986-2010) for diagnoses of KC and melanoma biennially. Cox proportional hazards models were used to compute hazard ratios (HRs) and 95% confidence intervals (CIs) of melanoma associated with history of KC, basal cell carcinoma (BCC), and squamous cell carcinoma (SCC). Read More

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