Naproxen Inhibits UVB-induced Basal Cell and Squamous Cell Carcinoma Development in Ptch1(+/-) /SKH-1 hairless mice.
- Sandeep C Chaudhary,
- Mohammad Waseem,
- Mehtab Rana,
- Hui Xu,
- Levy Kopelovich,
- Craig A Elmets,
- Mohammad Athar
Photochem Photobiol 2017 Mar 22. Epub 2017 Mar 22.
Department of Dermatology, VH509 University of Alabama at Birmingham, Birmingham, AL 35294-0019, USA.
Naproxen possesses anti-proliferative and pro-apoptotic effects besides its known anti-inflammatory functions. Here, we demonstrate the anti-cancer effects of naproxen against UVB-induced BCCs and SCCs in a highly susceptible murine model of UVB carcinogenesis. Naproxen significantly inhibited UVB-induced BCCs and SCCs in this model. Read More