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Gen Dent 2022 Jul-Aug;70(4):67-71

Hereditary hemorrhagic telangiectasia (HHT) is a rare condition in which fragile vascular walls lead to increased risks of bleeding, cerebral abscesses, arteriovenous malformations, anemia, and thrombosis. To date, no protocol has been established for optimizing the clinical outcomes of periodontal treatment in patients with this condition. The aim of this case report is to describe a safe clinical approach to periodontal treatment in a patient with HHT. Read More

Eur Rev Med Pharmacol Sci 2022 Jun;26(11):4113-4116

Department of Sense Organs, Sapienza University of Rome, Rome, Italy.

Objective: Since the outbreak of COVID-19 pandemic, the international scientific community aimed at developing a vaccine to protect against the infection and prevent serious forms of the disease. To date, various adverse events of COVID-19 vaccines have been reported, mostly mild to moderate.

Materials And Methods: In this short communication, we reviewed available literature and described the most frequent otolaryngology adverse events reported after COVID-19 vaccination. Read More

S D Med 2022 May;75(5):224-228

University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.

Epistaxis is a common otolaryngologic complaint experienced by 60 percent of the U.S. population and can be the result of either local or systemic disturbance. Read More

J Community Hosp Intern Med Perspect 2022 2;12(3):21-27. Epub 2022 May 2.

Greater Baltimore Medical Center, USA.

This is the first in a new series of case reports that will present real scenarios from our community hospital. The cases are chosen to highlight clinical dilemmas and offer review and perspective on what is currently known about the topic. We present the case of a 55-year-old Caucasian male who presented to the emergency department of our community hospital for worsening dyspnea. Read More

Skin Appendage Disord 2022 May 3;8(3):179-185. Epub 2022 Jan 3.

Instituto Dermatológico de Jalisco, Guadalajara, Mexico.

Introduction: Hematohidrosis and hemolacria are 2 conditions surrounded in religiousness, mysticism, and supernatural superstitions. While the mechanism is still unclear, these cases have amazed physicians for centuries.

Methods: We performed a systematic review in PubMed from 2000 to mid-2021 accounting for 75 studies from which we included 60 cases in 53 articles which were described. Read More

J Anaesthesiol Clin Pharmacol 2022 Jan-Mar;38(1):124-129. Epub 2021 Dec 1.

Department of Ear, Nose and Throat, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

Background And Aims: Awake fibreoptic nasotracheal intubation is associated with adverse airway and hemodynamic complications. The aim of this study was to evaluate the role of endotracheal tube size on nasal and laryngeal morbidity during awake fibreoptic-guided nasotracheal intubation.

Material And Methods: Eighty patients recruited to undergo awake fibreoptic intubation were randomly allocated to Group C (standard size endotracheal tube) and Group S (small size endotracheal tube followed by exchange to standard size using Airway Exchange Catheter under general anesthesia). Read More

Orphanet J Rare Dis 2022 06 13;17(1):220. Epub 2022 Jun 13.

The Center of Clinical Excellence for Hereditary Hemorrhagic Telangiectasias at the Johns Hopkins Hospital, Baltimore, MD, USA.

Background: For extreme hereditary hemorrhagic telangiectasia (HHT) disease, treatments such as intravenous bevacizumab are often utilized. However, whether its efficacy is similar across diverse races and ethnicities is unclear.

Methods: In this systematic review, we performed a search for English-language articles identified through PubMed, Embase, and Scopus databases whose research occurred in the United States (US). Read More

NMC Case Rep J 2022 18;9:117-121. Epub 2022 May 18.

Department of Neurosurgery, Medical Science College, Tokai University, Isehara, Kanagawa, Japan.

Epistaxis due to rupture of a nontraumatic internal carotid artery (ICA) aneurysm in the paranasal sinus has rarely been reported. Here, we report a case of double ICA aneurysms located within both the sphenoid and ethmoid sinuses. A 78-year-old woman presented with recurrent massive epistaxis. Read More

J Clin Med 2022 May 28;11(11). Epub 2022 May 28.

CIBERER, Unidad 707, Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain.

Hereditary Hemorrhagic Telangiectasia (HHT) is a rare disorder of vascular development. Common manifestations include epistaxis, telangiectasias and arteriovenous malformations in multiple organs. Different deletions or nonsense mutations have been described in the ENG (HHT1) or ACVRL1/ALK1 (HHT2) genes, all affecting endothelial homeostasis. Read More

J Clin Med 2022 May 25;11(11). Epub 2022 May 25.

Internal Medicine, University of Brescia-ASST Spedali Civili di Brescia, 25121 Brescia, Italy.

Background: Diagnosis and treatment of hypertension emergency (HE) and urgency (HU) may vary according to the physicians involved and the setting of the treatment. The aim of this study was to investigate differences in management of HE and HU according to the work setting of the physicians.

Methods: The young investigators of the Italian Society of Hypertension developed a 23-item questionnaire spread by email invitation to the members of Italian Scientific societies involved in the field of emergency medicine and hypertension. Read More

Front Med (Lausanne) 2022 19;9:871903. Epub 2022 May 19.

Department of Physiology and Pharmacology, Universidad de Salamanca, Salamanca, Spain.

Hereditary Hemorrhagic Telangiectasia (HHT) is an autosomal-dominant genetic disorder involving defects in two predominant genes known as endoglin (; HHT-1) and activin receptor-like kinase 1 (; HHT-2). It is characterized by mucocutaneous telangiectases that, due to their fragility, frequently break causing recurrent epistaxis and gastrointestinal bleeding. Because of the severity of hemorrhages, the study of the hemostasis involved in these vascular ruptures is critical to find therapies for this disease. Read More

Radiol Case Rep 2022 Aug 28;17(8):2607-2611. Epub 2022 May 28.

Radiology Department - CHU Hassan II. Faculty of Medicine and Pharmacy, Sidi Mohamed BenAbdellah University. Fez, Morocco.

Hemangioma of the facial sinuses is a rare pathology, and given the lack of clinical specificity, the differential diagnosis with a malignant lesion often arises. We report the case of a 32-year-old patient who consulted for recurrent epistaxis of moderate severity. The preoperative diagnosis of a hemangioma of the left maxillary sinus was based on computed tomography and magnetic resonance imaging data, confirmed by the anatomopathological study of the surgical specimen, preceded by an embolization that facilitated the endoscopic surgical excision. Read More

Drugs Real World Outcomes 2022 Jun 3. Epub 2022 Jun 3.

Department of Paediatrics, Medical Centre Leeuwarden, Leeuwarden, The Netherlands.

Background: Intranasal corticosteroids are one of the cornerstone treatment options for allergic rhinitis and chronic sinusitis complaints. Safety information in the summary of product characteristics may not be representative for observations in daily clinical practice. The Netherlands Pharmacovigilance Center (Lareb) collects post-marketing safety information, using spontaneous reporting systems. Read More

Int J Surg Case Rep 2022 May 4;94:107165. Epub 2022 May 4.

Department of Surgery, Dentistry, Gynaecology, and Paediatrics, Unit of Otorhinolaryngology, University of Verona, Verona, Italy.

Introduction And Importance: Schwannomas are benign neurogenic neoplasms with an uncommon involvement of the nasal cavity and paranasal sinus, which usually appear as a painless formation. We report two cases of nasal schwannoma that was successfully treated by surgical excision with satisfactory functional outcomes. The aim of this study is to discuss the clinical assessment and imaging, (CT, MRI) differential diagnosis, histological examination, surgical approaches of this rarely encountered neoplasm in the sinus-nasal area. Read More

HNO 2022 Jun 3. Epub 2022 Jun 3.

Klinik für Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie, Universitätsklinik Ulm, Frauensteige 12, 89075, Ulm, Deutschland.

Background: The incidence of acute ear, nose, and throat (ENT) diagnoses is influenced by multiple parameters, for example meteorological and seasonal influences. By better understanding the triggering factors, prophylactic approaches can be developed.

Materials And Methods: A retrospective analysis was performed over 6 years of all patients who presented to the university hospital because of typical and minor ENT emergencies. Read More

Curr Med Res Opin 2022 Jun 14:1-4. Epub 2022 Jun 14.

Department of Pharmacotherapy, Epidemiology and Economy, Faculty Pharmacy, University of Groningen, Groningen, The Netherlands.

Objective: In a previous study on the reasons for discontinuation of novel oral anticoagulation therapy (NOAC) in patients with atrial fibrillation, we showed that minor bleeding was the second most important reason for NOAC discontinuation. This finding suggest that the impact of minor bleeds on the patient's perspective on NOACs cannot be ignored, especially those minor bleeds for which the patient searched medical care. We therefore performed a study in which we explored the impact of minor bleed (clinically relevant non-major bleeds) on patient confidence in therapy, adherence to treatment and quality of life in AF patients using NOAC's. Read More

Hamostaseologie 2022 Jun 2. Epub 2022 Jun 2.

Department of Haematology, University Hospital, Jagiellonian University Medical College, Cracow, Poland.

Background:  Immune thrombocytopenia (ITP) is a disease with variable clinical presentation, requiring different treatment lines.

Aim:  The study aimed to characterize a group of ITP patients in terms of clinical picture and disease treatment, as well as to present the current standard of care of ITP in Poland, in the context of local and international guidelines.

Materials And Methods:  The study included adult patients diagnosed with ITP, treated at the Department of Haematology of the Jagiellonian University Hospital in Krakow from January 2006 to January 2021. Read More

Cureus 2022 Apr 27;14(4):e24517. Epub 2022 Apr 27.

Internal Medicine, Hayatabad Medical Complex Peshawar, Peshawar, PAK.

Hereditary hemorrhagic telangiectasia (HHT), also known as Osler-Weber-Rendu syndrome, is a very rare autosomal dominant genetic disorder that leads to abnormal blood vessel formation in the skin, mucus membranes (called telangiectasia), and organs such as the lung, liver, and brain. It occurs due to a mutation in one of the , , and  genes, which code for the formation of blood vessels. The most common symptom is recurring nosebleed (epistaxis; due to rupture of nasal mucosal telangiectasia), which begins in childhood and affects about 90-95% of people with HHT. Read More

Ann Med Surg (Lond) 2022 May 28;77:103685. Epub 2022 Apr 28.

Department of Otorhinolaryngology - Head and Neck Surgery, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.

Introduction And Importance: Glomangiopericytoma (GPC) is a rare sinonasal tumor that behaves benignly with a long overall survival rate. It accounts for fewer than 0.5% of all sinonasal tumors. Read More

Pediatr Neurol 2022 Jul 28;132:50-55. Epub 2022 Apr 28.

Neurelis, Inc., San Diego, California.

Background: To evaluate safety and tolerability of long-term treatment with diazepam nasal spray (Valtoco) for seizure clusters in patients aged six to 17 years.

Methods: The study enrolled patients aged six to 65 years with frequent seizure clusters. Age- and weight-based doses of diazepam nasal spray were administered; second doses were permitted if needed. Read More

Lasers Med Sci 2022 May 30. Epub 2022 May 30.

Salisbury Laser Clinic, Salisbury NHS Foundation Trust, Odstock Road, Salisbury, Wiltshire, SP2 8BJ, UK.

Using a patient survey, pulsed dye laser (PDL) treatment of epistaxis for hereditary haemorrhagic telangiectasia (HHT) patients was evaluated after initial referral. Subsequently, due to the COVID pandemic, a natural experimental set-up allowed assessment of an enforced withdrawal of treatment. A total of 34 subjects were identified as undergoing PDL for HHT-related epistaxis. Read More

Pak J Med Sci 2022 Mar-Apr;38(4Part-II):791-795

Dr. Naghmana Mazher, M. Phil (Hematology). Pathology Department, Fatima Jinnah Medical University, Lahore, Pakistan.

Objectives: To assess the utility of ISTH-BAT (International Society on Thrombosis and Hemostasis- Bleeding Assessment Tool) in the diagnosis of Glanzmann Thrombasthenia (GT) in comparison to controls.

Methods: It was a case-control study carried out at The Children's Hospital, Lahore from January 2012 to May 2021. All patients from neonates to 18 years with a final diagnosis of GT were studied retrospectively. Read More

Craniomaxillofac Trauma Reconstr 2022 Jun 8;15(2):147-163. Epub 2021 Apr 8.

Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Study Design: This is a literature review with 3 case studies.

Objective: Intraoperative and postoperative bleeding are the most common complications of orthognathic surgery and have the potential to become life-threatening. The rarity of severe postoperative epistaxis has resulted in limited characterization of these cases in the literature. Read More

West Afr J Med 2022 May;39(5):497-500

Department of Chemical Pathology, Abubakar Tafawa Balewa University Teaching Hospital, State, Nigeria.

Background: Acute leukaemias are very aggressive diseases that run a rapidly fatal course if not promptly diagnosed and appropriately treated. The clinical presentations range from bone marrow failure such as anaemia, neutropenia or thrombocytopenia to features of organ infiltrations such as lymphadenopathy, splenomegaly, etc, but presentations may be non-specific. Misdiagnosis is very common with delay in diagnosis and prompt treatment being the causes of high morbidity and mortality in acute leukaemias. Read More

Cancer Sci 2022 May 28. Epub 2022 May 28.

Saitama Medical University International Medical Center, Saitama, Japan.

New treatments, particularly second-line options, are needed to improve outcomes for patients with recurrent/metastatic cervical cancer (r/mCC). Tisotumab vedotin (TV) is an antibody-drug conjugate directed to tissue factor, a transmembrane protein commonly expressed in cancer cells, to deliver cytotoxic monomethyl auristatin E. This single-arm, open-label phase 1/2 trial evaluated the consistency of safety and efficacy outcomes of TV in Japanese patients with r/mCC to bridge the current findings with those reported in previous trials in non-Japanese patients in the United States and Europe. Read More

World J Otorhinolaryngol Head Neck Surg 2022 Mar 31;8(1):61-65. Epub 2022 Mar 31.

Department of Otolaryngology, Head and Neck Surgery Thomas Jefferson University Hospital Philadelphia USA.

Objectives: Patients with obstructive sleep apnea (OSA) are at increased risk of perioperative and postoperative morbidity. The use of continuous positive airway pressure (CPAP) in the perioperative period may be of potential benefit. However, among patients who have undergone endonasal skull base surgery, many surgeons avoid prompt re-initiation of CPAP therapy due to the theoretical increased risk of epistaxis, excessive dryness, pneumocephalus, repair migration, intracranial introduction of bacteria, and cerebrospinal fluid (CSF) leak. Read More

Clin Res Hepatol Gastroenterol 2022 May 21:101952. Epub 2022 May 21.

Department of Cardiology, Aalborg University Hospital, Denmark; Unit of Clinical Biostatistics and Epidemiology, Aalborg University Hospital, Denmark.

Background: Balancing the risk of thromboembolism and bleeding in patients with liver disease and atrial fibrillation/flutter is particularly challenging.

Purpose: To examine the risks of thromboembolism and bleeding with use/non-use of oral anticoagulation (including vitamin K-antagonists and direct oral anticoagulants) in patients with liver disease and AF.

Methods: Danish nationwide register-based cohort study of anticoagulant naive individuals with liver disease, incident atrial fibrillation/flutter, and a CHA2DS2-VASc-score≥1 (men) or ≥2 (women), alive 30 days after atrial fibrillation/flutter diagnosis. Read More

J Laryngol Otol 2022 May 24:1-17. Epub 2022 May 24.

Department of ENT and Head-Neck Surgery, Royal London Hospital, Barts Health NHS Trust.

Vestn Otorinolaringol 2022 ;87(2):80-83

Tyumen State Medical University, Tyumen, Russia.

A rare clinical case of recurrent nosebleeds associated with Randu-Osler disease, in which drug, hemostatic, transfusion therapy and combined nasal tamponade were ineffective, required ligation of the external carotid arteries on both sides, is presented. Read More

Ear Nose Throat J 2022 May 21:1455613221082622. Epub 2022 May 21.

Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 36630Wuhan, China.

SWItch/Sucrose Non-Fermentable related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1)-deficient sinonasal carcinoma (SDSC) is a malignant tumor classified as sinonasal undifferentiated carcinoma (SNUC). Owing to the high aggressiveness and poor prognosis reported in recent literature, patients diagnosed with SNUC should consider further immunohistochemical examination to screen for SDSC. Timely diagnosis is critical and will contribute to follow-up targeted therapy and improved patient prognosis. Read More