7,852 results match your criteria Epistaxis


Novel use of tranexamic acid to reduce the need for Nasal Packing in Epistaxis (NoPac) randomised controlled trial: research protocol.

BMJ Open 2019 Feb 15;9(2):e026882. Epub 2019 Feb 15.

Research Design Service South West, Bristol, UK.

Introduction: Patients presenting to emergency departments (EDs) with epistaxis uncontrolled by subsequent simple first aid measures or application of topical vasoconstrictors will typically undergo anterior nasal packing. Packing is effective, but can be extremely painful and unpleasant and patients usually need hospital admission. Tranexamic acid (TXA) is a cheap, safe, readily available antifibrinolytic agent known to be beneficial in a variety of clinical settings where uncontrolled bleeding may be a problem. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026882DOI Listing
February 2019

[Rendu-Osler disease and recurrent thromboembolic venous disease].

J Med Vasc 2019 Feb 12;44(1):76-78. Epub 2018 Dec 12.

Service de médecine interne, CHU Hédi Chaker, Sfax, Tunisie.

Rendu-Osler-Weber syndrome is a rare systemic fibrovascular dysplasia, recognized by mucocutaneous telangiectasias, arteriovenous malformations, epistaxis and family history. Venous thromboembolic disease is a poor prognostic factor in this disease given the risk of increased bleeding caused by anticoagulant therapy. We report a new case of a 56-year-old patient with Osler disease who developed recurrent thromboembolic venous disease when anticoagulants were discontinued. Read More

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http://dx.doi.org/10.1016/j.jdmv.2018.11.003DOI Listing
February 2019

Extracranial Internal Carotid Aneurysm in a 10-Year-Old Boy Diagnosed via Ultrasound.

Pediatr Emerg Care 2019 Feb 13. Epub 2019 Feb 13.

Johns Hopkins All Children's Hospital, St Petersburg, FL.

Background: Extracranial carotid aneurysms in children are extremely rare but carry a high mortality and morbidity. For pediatric patients, they are often complications of pharyngeal infections and surgical trauma but can also arise from congenital and inflammatory diseases. They have a wide range of presentation from an asymptomatic mass to a rapidly fatal hemorrhage. Read More

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http://dx.doi.org/10.1097/PEC.0000000000001759DOI Listing
February 2019

An enigmatic case of an uncommon syndrome: the Hughes-Stovin syndrome.

Ann Vasc Surg 2019 Feb 11. Epub 2019 Feb 11.

Department of Vascular and Endovascular Surgery, University Hospital Frankfurt am Main, Germany. Electronic address:

Hughes-Stovin syndrome is a disorder characterized by deep vein thrombosis and pulmonary artery aneurysms with potentially life-threatening complications. The case of a 22-year-old Moroccan male patient, presenting with signs of sepsis of unclear etiology, is presented here. CT scan revealed thrombosis of the inferior vena cava up to the hepatic veins, thrombosis of both common iliac veins and a thrombus in the right atrium. Read More

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http://dx.doi.org/10.1016/j.avsg.2018.11.018DOI Listing
February 2019

Local recurrence of sinonasal renal cell-like adenocarcinoma: A CARE compliant case report.

Medicine (Baltimore) 2019 Feb;98(7):e14533

Department of Pathology.

Rationale: Sinonasal renal cell-like adenocarcinoma (SNRCLA) is a very rare sino-nasal carcinoma. Because SNRCLA has the same morphological features as other clear cell carcinomas, and some of them also occurred in sinonasal part, it is necessary to differentiate SNRCLA from these tumors.

Patient Concerns: A 42-year-old man presented with complaints of epistaxis for 1 day. Read More

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http://dx.doi.org/10.1097/MD.0000000000014533DOI Listing
February 2019

Endoglin as an Adhesion Molecule in Mature and Progenitor Endothelial Cells: A Function Beyond TGF-β.

Front Med (Lausanne) 2019 30;6:10. Epub 2019 Jan 30.

Université Paris Descartes, Sorbonne Paris Cité, Paris, France.

Endoglin (ENG) is a transmembrane glycoprotein expressed on endothelial cells that functions as a co-receptor for several ligands of the transforming growth factor beta (TGF-β) family. ENG is also a recognized marker of angiogenesis and mutations in the endoglin gene are responsible for Hereditary Hemorrhagic Telangiectasia (HHT) type 1, a vascular disease characterized by defective angiogenesis, arteriovenous malformations, telangiectasia, and epistaxis. In addition to its involvement in the TGF-β family signaling pathways, several lines of evidence suggest that the extracellular domain of ENG has a role in integrin-mediated cell adhesion via its RGD motif. Read More

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http://dx.doi.org/10.3389/fmed.2019.00010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363663PMC
January 2019

Phenotype of CM-AVM2 caused by variants in EPHB4: how much overlap with hereditary hemorrhagic telangiectasia (HHT)?

Genet Med 2019 Feb 14. Epub 2019 Feb 14.

Department of Pathology, University of Utah, Salt Lake City, UT, USA.

Purpose: EPHB4 variants were recently reported to cause capillary malformation-arteriovenous malformation 2 (CM-AVM2). CM-AVM2 mimics RASA1-related CM-AVM1 and hereditary hemorrhagic telangiectasia (HHT), as clinical features include capillary malformations (CMs), telangiectasia, and arteriovenous malformations (AVMs). Epistaxis, another clinical feature that overlaps with HHT, was reported in several cases. Read More

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http://dx.doi.org/10.1038/s41436-019-0443-zDOI Listing
February 2019

A phase III study comparing secondary long-term prophylaxis versus on-demand treatment with vWF/FVIII concentrates in severe inherited von Willebrand disease.

Blood Transfus 2019 Feb 4:1-8. Epub 2019 Feb 4.

Division of Haematology and Transfusion Medicine, "Luigi Sacco" University Hospital, Milan, Italy.

Background: There is a lack of prospective clinical trials specifically designed to evaluate the benefits of prophylaxis with vWF/FVIII concentrates in patients with inherited von Willebrand disease (vWD). The aim of the study was to compare efficacy of secondary long-term prophylaxis (PRO) with vWF/FVIII in the prevention of bleeding episodes in severe vWD patients to standard of care (on-demand treatment; ODT).

Materials And Methods: In this 12-month, phase III, open-label study (PRO. Read More

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http://dx.doi.org/10.2450/2019.0183-18DOI Listing
February 2019

Endovascular Management of Epistaxis Secondary to Dissecting Pseudoaneurysm of the Descending Palatine Artery Following Orthognathic Surgery.

J Vasc Interv Neurol 2018 Nov;10(2):41-46

Department of Neurosurgery, New Jersey Medical School, Rutgers University, Newark, NJ, USA.

Orthognathic surgeries such as Le Fort I are widely used in clinical practice. Postoperative internal maxillary artery pseudoaneurysm is a very rare complication, which can lead to significant postoperative bleeding. In this article, we report a case of early postoperative bleeding secondary to pseudoaneurysm following Le Fort I surgery with a novel endovascular treatment approach. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350872PMC
November 2018

Tisotumab vedotin in patients with advanced or metastatic solid tumours (InnovaTV 201): a first-in-human, multicentre, phase 1-2 trial.

Lancet Oncol 2019 Feb 7. Epub 2019 Feb 7.

Department of Oncology, Phase 1 Unit, Rigshospitalet, Copenhagen, Denmark.

Background: Tisotumab vedotin is a first-in-human antibody-drug conjugate directed against tissue factor, which is expressed across multiple solid tumour types and is associated with poor clinical outcomes. We aimed to establish the safety, tolerability, pharmacokinetic profile, and antitumour activity of tisotumab vedotin in a mixed population of patients with locally advanced or metastatic (or both) solid tumours known to express tissue factor.

Methods: InnovaTV 201 is a phase 1-2, open-label, dose-escalation and dose-expansion study done at 21 centres in the USA and Europe. Read More

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http://dx.doi.org/10.1016/S1470-2045(18)30859-3DOI Listing
February 2019
2 Reads

Endovascular Embolization in the Treatment of Epistaxis.

Otolaryngol Head Neck Surg 2019 Feb 12:194599819829743. Epub 2019 Feb 12.

1 Department of Otolaryngology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

Objective: The cost-effectiveness of endovascular embolization (EE) for intractable epistaxis has been questioned, especially as endoscopic surgical techniques have become standard of care at many institutions. Our objectives were to review the safety profile and effectiveness of EE for epistaxis.

Study Design: Retrospective case series. Read More

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http://dx.doi.org/10.1177/0194599819829743DOI Listing
February 2019
1 Read

Clozapine Might Relieve Rhinotillexomania and Related Epistaxis in Schizophrenia Patients: A Case Report.

Am J Ther 2019 Jan 30. Epub 2019 Jan 30.

Department of Psychiatry, Beitou Branch, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

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http://dx.doi.org/10.1097/MJT.0000000000000943DOI Listing
January 2019
2 Reads

Nasal self-packing for epistaxis in Hereditary Hemorrhagic Telangiectasia increases quality of life.

Rhinology 2019 Feb 10. Epub 2019 Feb 10.

Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Marburg, Philipps-Universität Marburg, Marburg, Germany.

Statement Of Problem: Hereditary hemorrhagic telangiectasia (HHT) is characterized by recurrent epistaxis that can lead to a feeling of losing control. We assessed potential benefits and side effects of different nasal packings used by patients themselves.

Method Of Study: An online-questionnaire in English and German was used to analyze nasal self-packings. Read More

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http://dx.doi.org/10.4193/Rhin18.141DOI Listing
February 2019

A rare case of nasal septal schwannoma: Case report and literature review.

Int J Surg Case Rep 2019 Jan 30;55:149-151. Epub 2019 Jan 30.

Department of ENT, King Fahad Specialist Hospital, Dammam, Saudi Arabia. Electronic address:

Introduction: Sinonasal schwannoma accounts for only 4% of head and neck nerve sheath tumors. Schwannoma of the nasal septum is still the rarest, with only few cases previously reported.

Case Presentation: This study presents the case of a 64-year-old Saudi female of the Eastern Province who presented a several-month history of unilateral progressive nasal obstruction and recurrent episodes of epistaxis. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.01.027DOI Listing
January 2019

Bevacizumab Plus Direct Oral Anticoagulant Therapy in Ovarian Cancer Patients with Distal Deep Vein Thrombosis.

Clin Drug Investig 2019 Feb 8. Epub 2019 Feb 8.

Department of Obstetrics and Gynecology, Toho University Faculty of Medicine, 6-11-1 Omorinishi, Ota-ku, Tokyo, 143-8541, Japan.

Background And Objective: Administration of bevacizumab to ovarian cancer patients with distal deep vein thrombosis (DVT) is problematic because of lack of evidence about the likely outcomes. We conducted a preliminary study in ovarian cancer patients with DVT who received bevacizumab combined with a direct oral anticoagulant (DOAC).

Methods: We retrospectively investigated patients with advanced or recurrent epithelial ovarian cancer and distal DVT diagnosed by ultrasonography who underwent chemotherapy containing bevacizumab (15 mg/kg every 3 weeks) combined with DOAC therapy. Read More

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http://dx.doi.org/10.1007/s40261-019-00757-wDOI Listing
February 2019
1 Read

Blastic plasmacytoid dendritic cell neoplasm with unusual extracutaneous manifestation: Two case reports and literature review.

Medicine (Baltimore) 2019 Feb;98(6):e14344

Department of Pathology, Konkuk University School of Medicine, Seoul, Korea.

Rationale: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematologic malignancy. This disease almost always presents with cutaneous involvement.

Patient Concerns: The 1st patient was a 16-year-old girl who presented with recurrent epistaxis. Read More

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http://dx.doi.org/10.1097/MD.0000000000014344DOI Listing
February 2019
1 Read

Shorter hospital stays in epistaxis patients with atrial fibrillation when taking rivaroxaban or apixaban versus phenprocoumon.

J Thromb Thrombolysis 2019 Feb 7. Epub 2019 Feb 7.

Department of Otolaryngology, Head/Neck & Facial Plastic Surgery, Sana Kliniken Leipziger Land, Rudolf-Virchow-Strasse 2, 04552, Borna, Germany.

Patients taking oral anticoagulants (OACs) currently represent one-third of all patients treated for epistaxis and an upward trend is expected. New direct oral anticoagulants (DOACs) have been on the market for approximately 10 years. DOACs are favoured over Vitamin K-Antagonists (VKAs) in the current guidelines. Read More

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http://dx.doi.org/10.1007/s11239-019-01824-xDOI Listing
February 2019

Adrenocorticotropic Hormone-Dependent Cushing Syndrome Caused by an Olfactory Neuroblastoma.

Clin Med Insights Endocrinol Diabetes 2019 31;12:1179551419825832. Epub 2019 Jan 31.

Department of Endocrinology, Hospital Clinico San Carlos, Madrid, Spain.

Olfactory neuroblastoma (ONB) is an unusual malignant neoplasm originating from the olfactory neuroepithelium. Secretion of adrenocorticotropic hormone (ACTH) from this tumor has been exceptionally reported. We describe a young man with resistant hypertension and a cushingoid phenotype. Read More

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http://dx.doi.org/10.1177/1179551419825832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357293PMC
January 2019
1 Read

Regarding epistaxis in the setting of antithrombotic therapy: A comparison between factor Xa inhibitors, warfarin, and antiplatelet agents.

Laryngoscope 2019 Feb 6. Epub 2019 Feb 6.

New York University School of Medicine, Ronald O. Perelman Department of Emergency Medicine, Division of Medical Toxicology, New York, New York, U.S.A.

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http://dx.doi.org/10.1002/lary.27824DOI Listing
February 2019

In response to Epistaxis in the setting of antithrombotic therapy: A comparison between factor Xa inhibitors, warfarin, and antiplatelet agents.

Authors:
Eran Glikson

Laryngoscope 2019 Feb 6. Epub 2019 Feb 6.

Department of Otolaryngology-Head and Neck Surgery, Sheba Medical Center, Tel-Hashomer, Israel.

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http://dx.doi.org/10.1002/lary.27817DOI Listing
February 2019

Complications associated with nasotracheal intubation and proposal of simple countermeasure.

Anaesthesiol Intensive Ther 2019 Feb 6. Epub 2019 Feb 6.

Department of Paediatric Anaesthesiology and Critical Care Medicine, Asklepios Kinderklinik Sankt Augustin, German Paediatric Heart Centre, Arnold-Janssen Street 29, 53757 Sankt Augustin, Germany.

To the Editor, Nasotracheal intubation is a widely used technique in anaesthesia management for procedures including oropharyngeal, dental, and maxillofacial surgeries[1-3]. It provides an uninhibited access to the mouth and plays an important role when dealing with difficult airways[4-6]. It is also used in patients with cervical spine instability owing to injury[7] or in patients with a cervical spine fixation owing to a disease or previous operation[8]. Read More

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http://dx.doi.org/10.5603/AIT.a2019.0002DOI Listing
February 2019
2 Reads

Esthesioneuroblastoma: An Unusual Presentation with Intractable Headache.

Cureus 2018 Nov 28;10(11):e3653. Epub 2018 Nov 28.

Radiology, Osceola Regional Medical Center, Kissimmee, USA.

Esthesioneuroblastoma, also known as olfactory neuroblastoma, is a malignant tumor of the upper nasal cavity. This report illustrates the case of a 63-year-old woman who presented with intractable headaches. Subsequent radiologic evaluation and correlation with histopathologic analysis confirmed esthesioneuroblastoma. Read More

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http://dx.doi.org/10.7759/cureus.3653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351115PMC
November 2018
1 Read

A Time Bomb Defused, In Time! A Traumatic Optic Neuropathy To Be Wary Of.

Neuroophthalmology 2019 Feb 13;43(1):32-35. Epub 2018 Jun 13.

Department of Radiology and Imaging Services, Senior Interventional Radiologist Apollo Hospitals, Chennai, India.

Authors describe a case of traumatic pseudoaneurysm of cavernous internal carotid artery in a young male who presented with complaints of progressive decrease in vision, inability to move the eye, and delayed epistaxis 8 months after the head injury sustained during a motor vehicle accident. The presence of optic atrophy and epistaxis in the setting of head trauma alerted the authors to look for this potentially life-threatening condition. Timely intervention in the form of endovascular coil occlusion of the internal carotid artery was performed and the epistaxis stopped without any ischaemic or thromboembolic sequaelae. Read More

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https://www.tandfonline.com/doi/full/10.1080/01658107.2018.1
Publisher Site
http://dx.doi.org/10.1080/01658107.2018.1458886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351014PMC
February 2019
2 Reads

Cost-effectiveness of trans-nasal endoscopic sphenopalatine artery ligation vs. arterial embolisation for intractable epistaxis: long-term analyses.

Clin Otolaryngol 2019 Feb 5. Epub 2019 Feb 5.

Otorhinolaryngology, Head and Neck Surgery Department, University Hospital Rangueil-Larrey, Toulouse, France.

Objectives: Trans-nasal endoscopic sphenopalatine artery ligation (TESPAL) and endovascular arterial embolisation both provide excellent success rates for intractable epistaxis. Recent economic models suggest that TESPAL could be a cost-saving strategy. Our main aim was to perform cost-effectiveness analyses on TESPAL compared to embolisation to treat patients with epistaxis. Read More

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http://dx.doi.org/10.1111/coa.13299DOI Listing
February 2019
1 Read

Influence of exposing dental implants into the sinus cavity on survival and complications rate: a systematic review.

Int J Implant Dent 2019 Feb 5;5(1). Epub 2019 Feb 5.

Department of Oral and Maxillofacial Surgery, International University of Catalonia, C/Josep Trueta Sn, Sant Cugat del Vallés, C.P 08195, Barcelona, Spain.

Background: After tooth loss, the posterior maxilla is usually characterized by limited bone height secondary to pneumatization of the maxillary sinus and/or collapse of the alveolar ridge that preclude in many instances the installation of dental implants. In order to compensate for the lack of bone height, several treatment options have been proposed. These treatment alternatives aimed at the installation of dental implants with or without the utilization of bone grafting materials avoiding the perforation of the Schneiderian membrane. Read More

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http://dx.doi.org/10.1186/s40729-019-0157-7DOI Listing
February 2019
1 Read

Pediatrics Ewing's Sarcoma of the Sinonasal Tract: A Case Report and Literature Review.

Case Rep Pathol 2019 2;2019:8201674. Epub 2019 Jan 2.

Department of ENT, King Fahad Specialist Hospital, Ministry of Health, Dammam, Saudi Arabia.

Ewing's sarcoma (ES) is a highly malignant, small, round cell tumor that originates from the primitive neuroectodermal cells. Primary ES commonly occurs in early childhood or adolescence. It may present with skeletal and extraskeletal forms. Read More

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http://dx.doi.org/10.1155/2019/8201674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334347PMC
January 2019

Safety of thalidomide and bevacizumab in patients with hereditary hemorrhagic telangiectasia.

Orphanet J Rare Dis 2019 Feb 4;14(1):28. Epub 2019 Feb 4.

VASCERN HHT Reference Center, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, and Vascular Sciences, National Heart and Lung Institute, Imperial College London, London, UK.

Background: Hereditary hemorrhagic telangiectasia (HHT) is a multisystemic inherited vascular dysplasia that leads to nosebleeds and visceral arteriovenous malformations (AVMs). Anti-angiogenic drugs thalidomide and bevacizumab have been increasingly used off-label with variable results. The HHT working group within the ERN for Rare Multisystemic Vascular Diseases (VASCERN), developed a questionnaire-based retrospective capture of adverse events (AEs) classified using the Common Terminology Criteria for Adverse Events. Read More

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http://dx.doi.org/10.1186/s13023-018-0982-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360670PMC
February 2019
1 Read

Long-term effects of intracapsular debulking and adjuvant somatostatin analogs for growth hormone-secreting pituitary macroadenoma: 10 years of experience in a single institute.

World Neurosurg 2019 Feb 1. Epub 2019 Feb 1.

Department of Minimally Invasive Skull Base Neurosurgery, Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan; Department of Physical Therapy, Hung Kuang University, Taichung, Taiwan. Electronic address:

Objective: Long-term effects of endoscopic endonasal transsphenoidal intracapsular debulking and adjuvant somatostatin analogs were evaluated in patients with growth hormone secreting pituitary macroadenomas.

Methods: We retrospectively reviewed the medical records of 45 patients with acromegalic macroadenoma who underwent endonasal endoscopic transsphenoidal intracapsular debulking and received adjuvant somatostatin analogs (octreotide) between 2006 and 2015, who had more than 1 year of follow-up. To evaluate the predictive factors for 1 year and long-term biochemical outcomes, univariate and multivariate analyses were performed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193022
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http://dx.doi.org/10.1016/j.wneu.2019.01.125DOI Listing
February 2019
2 Reads

Delayed Pipeline embolization of a ruptured true internal carotid artery aneurysm presenting with epistaxis: Case report and review of the literature.

World Neurosurg 2019 Feb 1. Epub 2019 Feb 1.

Lyerly Neurosurgery, Baptist Medical Center, Jacksonville, Florida, USAs.

Background: Massive epistaxis from rupture of an intracavernous internal carotid artery (ICA) aneurysm is a potentially fatal event. Although rare, this presentation is seen most often in patients after trauma or iatrogenic injury secondary to transsphenoidal surgery or radiation therapy.

Case Description: We present our unusual case of a patient with no significant risk factors who had recurrent epistaxis due to a ruptured true cavernous ICA aneurysm. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.126DOI Listing
February 2019

Sudden Tachycardia Due to Submucosal Migration of an Epinephrine-Soaked Swab During Nasal Intubation.

Anesth Prog 2018 ;65(4):259-260

Department of Anesthesiology, Showa University Koto Toyosu Hospital, Tokyo, Japan.

A 23-year-old healthy man was scheduled for extraction of his mandibular third molars under general anesthesia with nasotracheal intubation. Sudden sinus tachycardia up to 170 beats/min occurred when applying an epinephrine solution-soaked swab into the nasal cavity for preventing epistaxis during intubation. This was presumably evoked by submucosal migration of the swab into a false passage created because of the force applied during a prior failed attempt at nasal passage of the tracheal tube, and rapid epinephrine absorption by the traumatized mucosa. Read More

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http://dx.doi.org/10.2344/anpr-66-01-02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318739PMC
January 2018
1 Read

Identification of bleeding sites and microwave thermal ablation of posterior epistaxis.

Acta Otolaryngol 2019 Feb 2:1-5. Epub 2019 Feb 2.

d Department of Clinical Medicine , Xinxiang Medical University , Xinxiang City, Xinxiang , China.

Background: Microwave ablation (MWA) is a relatively new technique which has been used to achieve hemostasis at surgical field. However, few publications have reported MWA for epistaxis.

Objectives: Our objectives were to identify the bleeding sites/points in instances of posterior epistaxis and to evaluate the efficacy of MWA for controlling bleeding. Read More

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http://dx.doi.org/10.1080/00016489.2018.1552016DOI Listing
February 2019

"As Needed" nonvitamin K antagonist oral anticoagulants for infrequent atrial fibrillation episodes following atrial fibrillation ablation guided by diligent pulse monitoring: A feasibility study.

J Cardiovasc Electrophysiol 2019 Feb 1. Epub 2019 Feb 1.

Department of Medicine, Electrophysiology Section, Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.

Introduction: After atrial fibrillation (AF) ablation, oral anticoagulation (OAC) is recommended if stroke risk as assessed by CHA DS -VASc score is high. However, patients without AF are often reluctant to take daily OAC. We describe outcome using as needed nonvitamin K antagonist (NOACs) guided by pulse monitoring to detect AF following successful ablation. Read More

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http://dx.doi.org/10.1111/jce.13859DOI Listing
February 2019
1 Read

Microwave ablation for the treatment of arterial epistaxis: "how I do it".

Int Forum Allergy Rhinol 2019 Jan 31. Epub 2019 Jan 31.

Department Clinical Class No.11, Clinical Medicine, Xinxiang Medical University, Henan, China.

Background: Arterial epistaxis is commonly seen in the rhinology clinic and can have a significant impact on quality of life. Previous studies have explored various therapies to address epistaxis.

Methods: Patients were treated in the outpatient clinic or operating room by microwave ablation (MWA) with a 2450-MHz cooled-shaft antenna to treat an epistaxis bleeding point. Read More

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http://dx.doi.org/10.1002/alr.22304DOI Listing
January 2019

Syndromes that predispose to epistaxis.

Eur Arch Otorhinolaryngol 2019 Jan 30. Epub 2019 Jan 30.

Department of Otorhinolaryngology, 3rd Faculty of Medicine and University Hospital Kralovske Vinohrady, Charles University, Srobarova 1150/50, 10034, Prague, Czech Republic.

Purpose: Our aim was to evaluate if epistaxis is directly associated with the etiology or pathophysiological mechanism which results in the syndrome itself or arises as a secondary effect.

Methods: We performed an extensive literature review of the web-based PubMed database from the National Library of Medicine to ascertain syndromes related to this condition. Etiology, pathophysiological mechanisms, occurrence, clinical features and management were noted for each of these syndromes. Read More

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http://dx.doi.org/10.1007/s00405-019-05310-1DOI Listing
January 2019

Significant Hematochezia and Intracranial Bleeding in Neonatal Hereditary Hemorrhagic Telangiectasia.

AJP Rep 2019 Jan 29;9(1):e10-e14. Epub 2019 Jan 29.

Department of Human Genetics, Emory University, Atlanta, Georgia.

Hereditary hemorrhagic telangiectasia (HHT) is an underreported autosomal dominant vascular dysplasia. Neonatal presentations of HHT are rare, as this disorder typically presents in adolescence or beyond with epistaxis. We report a female neonate with hematochezia on the 1st day of life secondary to multiple gastrointestinal arteriovenous malformations (AVMs) along with intracranial hemorrhage. Read More

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http://dx.doi.org/10.1055/s-0039-1677735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351274PMC
January 2019
1 Read

Bevacizumab as Treatment for Epistaxis in Hereditary Hemorrhagic Telangiectasia: A Literature Review.

Ann Otol Rhinol Laryngol 2019 Jan 29:3489419826139. Epub 2019 Jan 29.

2 Texas Children's Hospital, Houston, Texas, USA.

Background:: Severe, recurring epistaxis is the most common symptom of hereditary hemorrhagic telangiectasias (HHT). Current treatment modalities range from noninvasive treatments that frequently fail to achieve even short-term control to surgeries and systemic therapies that carry significant risk of complications. Recently, bevacizumab, a VEGF inhibitor, has been proposed as an alternative option to alleviate epistaxis symptoms in HHT. Read More

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http://dx.doi.org/10.1177/0003489419826139DOI Listing
January 2019

The Stratified Population Screening of Hereditary Hemorrhagic Telangiectasia.

Pathol Oncol Res 2019 Jan 26. Epub 2019 Jan 26.

Division of Clinical Laboratory Science, Department of Laboratory Medicine, University of Debrecen, Nagyerdei krt. 98, Debrecen, H-4032, Hungary.

Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant multisystemic vascular disease with a wordwide prevalence of 1:5000-1:10000. We introduce our algorithm for the stratified population screening of HHT. Probands are selected from the consecutive hospital database review for HHT (I7800) and recurrent epistaxis (R0400) and the review of patient records referred by family practicioners. Read More

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http://dx.doi.org/10.1007/s12253-019-00602-7DOI Listing
January 2019
3 Reads
1.806 Impact Factor

A modified endovascular treatment protocol for iatrogenic internal carotid artery injuries following endoscopic endonasal surgery.

J Neurosurg 2019 Jan 25:1-8. Epub 2019 Jan 25.

2Neurosurgery, Beijing Neurosurgical Institute and Beijing Tiantan Hospital, Capital Medical University.

OBJECTIVEInternal carotid artery (ICA) injuries during endoscopic endonasal surgery (EES) are catastrophic complications. Alongside the advancements in medical instrumentation and material, there is a need to modify previous treatment modalities and principles.METHODSA retrospective review of 3658 patients who underwent EES performed at the authors' institution between January 2012 and December 2017 was conducted. Read More

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http://dx.doi.org/10.3171/2018.8.JNS181048DOI Listing
January 2019
1 Read
3.737 Impact Factor

Malignant peripheral nerve sheath tumor of the nasal cavity and nasopharynx in a child: A case report.

Medicine (Baltimore) 2019 Jan;98(4):e14223

Department of Radiology, Shenzhen Children's Hospital, Shenzhen, Guangdong, China.

Rationale: Malignant peripheral nerve sheath tumors (MPNSTs) are rare neoplasms with only a few reported cases affecting the nasal cavity, paranasal sinuses, and anterior skull base.

Patient Concerns: A 12-year-old girl with a mass in her nose was admitted to the Department of Otorhinolaryngology of Shenzhen Children's Hospital. She had a 4-month history of progressive, unilateral right nasal obstruction, unilateral mucopurulent rhinorrhea, foul nasal odor, snoring, hyposmia, occasional epistaxis, and no headache, no facial numbness, without eye swelling and vision loss. Read More

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http://dx.doi.org/10.1097/MD.0000000000014223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358413PMC
January 2019
2 Reads
5.723 Impact Factor

Epistaxis audit revisited.

J Laryngol Otol 2018 Dec;132(12):1045

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http://dx.doi.org/10.1017/S0022215118002311DOI Listing
December 2018

Topical Mitomycin-C can help as an adjunct to alkaline nasal wash and rifampicin in primary atrophic rhinitis.

Am J Otolaryngol 2019 Jan 16. Epub 2019 Jan 16.

Otolaryngology, Head and Neck Department, Minia Medical Insurance Hospital, Minia, Egypt.

Purpose: Primary atrophic rhinitis (PAR) is a well-known old disease characterized by a roomy nose and extensive crustations. This study was designed to investigate the effect of topical Mitomycin-C as an adjunct to medical treatment with respect to objective and subjective improvement in patients treated with PAR.

Material And Methods: This prospective randomized controlled study was conducted in a tertiary referral hospital in January 2016 and March 2018. Read More

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http://dx.doi.org/10.1016/j.amjoto.2019.01.007DOI Listing
January 2019

[Efficacy and safety of monotherapy versus combination therapy in treatment of allergic rhinitis : a Meta-analysis].

Authors:
J Li Y Shen Q Y Zou

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Jan;33(1):41-46

Department of Otorhinolaryngology Head and Neck surgery,the First Affiliated Hospital of Chongqing Medical University,Chongqing,400016,China.

To evaluate efficacy and safety of monotherapy versus combination therapy on allergic rhinitis(AR) in order to provide evidencebased reference for clinic drug treatment of AR.The randomized controlled trials(RCT) about drug treatment of AR were searched in PubMed, Embase, Cochrane library, CNKI, WanFang Data. After screening the literatures, extracting the data and evaluating the quality, to compare total nasal symptom scores(TNSS),composite symptom scores(CSS),daytime nasal symptom scores(DNSS),individual nasal symptom scores, total ocular symptom scores(TOSS), daytime eye symptom scores(DESS)and incidence of adverse events(AE)between monotherapy group and combination therapy group. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2019.01.009DOI Listing
January 2019
1 Read

Oral Manifestation as the Main Sign of an Advanced Stage Acute Promyelocytic Leukemia.

Acta Stomatol Croat 2018 Dec;52(4):358-362

Departamento de Medicina Oral e Odontologia Infantil. Universidade Estadual de Londrina. Rua Pernambuco 540, Londrina-PR. Brasil.

Acute myeloid leukemia is an aggressive malignant neoplasm occurring mainly in elderly, with the median age of 65 years. Oral manifestations, mainly spontaneous bleeding, are a common finding in acute myelocytic leukemia and may represent the initial evidence of the disease. This report describes a case of a 47-year-old man with a one-month history of spontaneous oral bleeding. Read More

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http://dx.doi.org/10.15644/asc52/4/10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336446PMC
December 2018
1 Read

Desmopressin for treating nocturia in patients with multiple sclerosis: A systematic review: A report from the Neuro-Urology Promotion Committee of the International Continence Society (ICS).

Neurourol Urodyn 2019 Jan 17. Epub 2019 Jan 17.

Department of Neuro-Urology, Balgrist University Hospital, University of Zürich, Zürich, Switzerland.

Aims: To systematically assess all available evidence on efficacy and safety of desmopressin for treating nocturia in patients with multiple sclerosis (MS).

Methods: This systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Studies were identified by electronic search of Cochrane register, Embase, Medline, Scopus (last search March 3, 2018) and by screening of reference lists and reviews. Read More

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http://dx.doi.org/10.1002/nau.23921DOI Listing
January 2019
2 Reads

Oral tranexamic acid associated with platelet transfusion to prevent hemorrhage in a patient with Glanzmann thrombasthenia.

Gen Dent 2019 Jan-Feb;67(1):61-65

Glanzmann thrombasthenia (GT) is a rare genetic disorder that alters platelet function. The clinical manifestations include purpura, epistaxis, gingival bleeding, and menorrhagia. For patients with GT, conventional surgical dental treatment may result in hemorrhagic complications. Read More

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January 2019
1 Read

Etiology, Management, and Outcome of Pediatric Epistaxis.

Pediatr Emerg Care 2019 Jan 7. Epub 2019 Jan 7.

Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Munich, Munich.

Objective: Epistaxis in children is one of the most common causes for seeking professional medical help. Patients may be treated by several disciplines with various approaches to pediatric epistaxis. We reviewed cases of pediatric epistaxis from an otorhinolaryngologist's point of view. Read More

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http://dx.doi.org/10.1097/PEC.0000000000001698DOI Listing
January 2019

Clinical characteristics of patients with granulomatosis with polyangiitis and microscopic polyangiitis in ENT practice: a comparative analysis.

Acta Otorhinolaryngol Ital 2018 Dec;38(6):517-527

Department and Clinic of Otolaryngology, Head and Neck Surgery, Wrocław Medical University Hospital, Borowska, Poland.

ENT manifestations are commonly observed in patients with small vessel vasculitis (SVV). The main aim of this study was to analyse and present the clinicopathological characteristics of individuals with SVV emphasising otorhinolaryngological symptoms. This study evaluated 64 patients, 41 with granulomatosis with polyangiitis (GPA) and 23 with microscopic polyangiitis (MPA). Read More

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http://dx.doi.org/10.14639/0392-100X-1776DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325653PMC
December 2018
2 Reads

Morphometric evaluation and clinical implications of the greater palatine foramen, greater palatine canal and pterygopalatine fossa on CBCT images and review of literature.

Surg Radiol Anat 2019 Jan 8. Epub 2019 Jan 8.

Department of Dentomaxillofacial Radiology, Faculty of Dentistry, Gaziantep University, Gaziantep, Turkey.

Introduction: The pterygopalatine fossa (PPF) infiltration is performed to reduce blood flow during endoscopic sinus surgery and septorhinoplasty, as well as to control posterior epistaxis and provide regional anesthesia in dental procedures. PPF infiltration performed with consideration of the morphometrics of greater palatine foramen (GPF), greater palatine canal (GPC) and PPF would increase the success of the procedure and reduce the risk of complications. The aim of this study is to investigate the GPF, GPC, lesser palatine foramen (LPF), lesser palatine canal (LPC) and PPF morphology via the images obtained by CBCT, to provide information for interventional procedures. Read More

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http://link.springer.com/10.1007/s00276-019-02179-x
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http://dx.doi.org/10.1007/s00276-019-02179-xDOI Listing
January 2019
5 Reads
1.333 Impact Factor

Munchausen by proxy syndrome mimicking childhood-onset systemic lupus erythematosus.

Lupus 2019 Jan 7:961203318821156. Epub 2019 Jan 7.

1 Pediatric Rheumatology Unit, Children's Institute, Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.

Childhood-onset systemic lupus erythematosus (cSLE) is a chronic inflammatory multisystem autoimmune disease that requires multiple differential diagnoses. Munchausen by proxy syndrome (MBPS) is a form of child abuse, where a caregiver intentionally creates a medical history and induces or fabricates signs or disease in a patient. To our knowledge, there is no case report of MBPS mimicking cSLE diagnosis. Read More

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http://dx.doi.org/10.1177/0961203318821156DOI Listing
January 2019
2 Reads