8,350 results match your criteria Epistaxis


Rapid Screening and Identification of Chemical Constituents From Ophiopogon japonicus by High-Performance Liquid Chromatography Coupled to Electrospray Ionization and Quadrupole Time-of-Flight Mass Spectrometry.

J Chromatogr Sci 2020 Jul 2. Epub 2020 Jul 2.

Department of Pharmaceutical and Life Sciences, Jiujiang University, Jiujiang 332005, People's Republic of China.

Ophiopogon japonicus (Thunb.) Ker-Gawl (Liliaceae), which is named as "Maidong" in China, is widely used in traditional Chinese medicine for treating fever, cough, inflammation, epistaxis, constipation, respiratory disease and gastrointestinal disorders. However, the systematic analysis of chemical constituents of O. Read More

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http://dx.doi.org/10.1093/chromsci/bmaa029DOI Listing

Is There a Relationship Between Epitaxis and Anatomical Variations?

Eurasian J Med 2020 Jun 29;52(2):136-138. Epub 2019 Jul 29.

Department of Plastic Reconstructive and Aesthetic Surgery, Ataturk University School of Medicine, Erzurum, Turkey.

Objective: The aim of our study is to introduce the relationship between epistaxis and anatomical variations and present the current treatment approach.

Materials And Methods: Forty-five patients (28 males and 17 females) that presented to otorhinolaryngology clinics at Mengucek Gazi Training and Research Hospital with pre-diagnosed epistaxis between October 2018 and April 2019 were included in the study. Age, sex and structural causes and anatomical localization of epistaxis in patients were analysed. Read More

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http://dx.doi.org/10.5152/eurasianjmed.2020.19222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311124PMC

Successful treatment of refractory secondary immune thrombocytopenia (antiphospholipid antibody syndrome-associated) with the combination of rituximab and romiplostim at the cost of severe bone pain: A case report and review of literature.

J Oncol Pharm Pract 2020 Jul 1:1078155220935490. Epub 2020 Jul 1.

Department of Internal Medicine, Istanbul University-Cerrahpasa Faculty of Medicine, Istanbul, Turkey.

Introduction: Immune thrombocytopenia is an autoimmune disorder associated with increased thrombocyte destruction and impaired production in the bone marrow. Proposed mechanisms include an antibody or autoreactive T-cell-associated autoimmunity and thrombopoietin deficiency among others. Clinical manifestations are predominantly mucocutaneous hemorrhages including petechiae, purpura, mucosal bleeding in the urinary or the gastrointestinal tracts, menorrhagia, and epistaxis. Read More

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http://dx.doi.org/10.1177/1078155220935490DOI Listing

Floseal: a novel application technique for the treatment of challenging epistaxis.

Clin Otolaryngol 2020 Jul 1. Epub 2020 Jul 1.

Consultant Otorhinolaryngologist, Head and Neck Surgeon, University Hospital Southampton NHS Foundation Trust, UK.

There were 24,719 emergency admissions for epistaxis in English NHS trusts from April 2017-April 2018. Epistaxis is initially managed with external nasal pressure and ice, then cautery, nasal packing, surgery or embolisation, in ascending order. There is growing evidence for Floseal use in anterior and posterior epistaxis. Read More

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http://dx.doi.org/10.1111/coa.13604DOI Listing

Coagulation disorders in Duchenne muscular dystrophy? Results of a registry-based online survey.

Acta Myol 2020 Mar 1;39(1):2-12. Epub 2020 Mar 1.

Department of Neuropediatrics and Muscle Disorders, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.

Different complications of hemostasis have been reported in patients with Duchenne Muscular Dystrophy (DMD). These comprise an increased rate of bleeding-symptoms during scoliosis surgery but also thromboembolic complications such as pulmonary embolism, cerebral infarction, deep vein thrombosis or cardiac thrombus. For this cross-sectional study, personalized online survey-links were forwarded to 682 registered patients with a genetically confirmed diagnosis of DMD via the German-Austrian DMD patient registry (www. Read More

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http://dx.doi.org/10.36185/2532-1900-001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315897PMC

Extranasopharyngeal Angiofibroma Localized in the Nasal Dorsum: A Rare Location for This Tumor.

Sisli Etfal Hastan Tip Bul 2018 28;52(3):229-231. Epub 2018 Sep 28.

Department of ENT, Şişli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey.

Although extranasopharyngeal angiofibroma (ENA) is a rare condition, its diagnosis should be considered during differential diagnosis of nasal masses. We report a rare case of ENA originating from the left lateral side of nasal tip. A 43-year-old man with an ENA mass located on the left lateral side of the nasal tip presented to our hospital. Read More

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http://dx.doi.org/10.5350/SEMB.20170508042536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315094PMC
September 2018

Factors associated with bleeding events in patients on rivaroxaban for non-valvular atrial fibrillation: A real-world experience.

Int J Cardiol 2020 Jun 26. Epub 2020 Jun 26.

Division of Cardiology, John H Stroger Jr Hospital of Cook County, Chicago, USA.

Background: Rivaroxaban is a direct oral anticoagulant (DOAC) approved for the treatment of non-valvular atrial fibrillation (NVAF). Data related to the risk factors associated with rivaroxaban-induced bleeding in patients with NVAF remain scarce in the community setting. We sought to investigate these bleeding risk factors in a racially diverse patient population. Read More

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http://dx.doi.org/10.1016/j.ijcard.2020.06.032DOI Listing
June 2020
4.036 Impact Factor

Randomised controlled trial comparing efficacy and safety of high versus low Low-Molecular Weight Heparin dosages in hospitalized patients with severe COVID-19 pneumonia and coagulopathy not requiring invasive mechanical ventilation (COVID-19 HD): a structured summary of a study protocol.

Trials 2020 Jun 26;21(1):574. Epub 2020 Jun 26.

Servizio Formazione, Ricerca e Innovazione, Azienda Ospedaliero-Universitaria di Modena, Ospedale Policlinico, Modena, Italy.

Objectives: To assess whether high doses of Low Molecular Weight Heparin (LMWH) (i.e. Enoxaparin 70 IU/kg twice daily) compared to standard prophylactic dose (i. Read More

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http://dx.doi.org/10.1186/s13063-020-04475-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316577PMC

FID Score: an effective tool in Hereditary Haemorrhagic Telangiectasia - related epistaxis.

Rhinology 2020 Jun 25. Epub 2020 Jun 25.

Department of Otorhinolaryngology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

Background: Hereditary haemorrhagic telangiectasia (HHT) is a rare disease characterized by a multisystemic vascular dysplasia and epistaxis, that is the most common cause of disability and social impairment. Patient management strictly depends on the severity of this symptom; therefore, it is of paramount importance for the clinicians to effectively grade epistaxis severity. The aim of this report was to validate the Frequency, Intensity and Duration score (FID) for grading epistaxis severity in patients with HHT; we studied repeatability and external validity comparing FID score with Epistaxis Severity Score (ESS). Read More

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http://dx.doi.org/10.4193/Rhin20.078DOI Listing

Real-world non-interventional long-term post-authorisation safety study of ruxolitinib in myelofibrosis.

Br J Haematol 2020 Jun 24. Epub 2020 Jun 24.

Department of Hematology and Blood Coagulation, Medical University of Vienna, Vienna, Austria.

Primary objective of this non-interventional, post-authorisation safety study was to provide real-world safety data [incidence of adverse drug reactions (ADRs)/serious adverse events (SAEs)] on adult patients with myelofibrosis exposed/or not exposed to ruxolitinib. Key secondary objectives included the incidence/outcome of events of special interest (bleeding events, serious/opportunistic infections, second primary malignancies, and deaths). Overall, 462 patients were included [prevalent users = 260, new users = 32, non-exposed = 170 (inclusive of ruxolitinib-switch, n = 57)]. Read More

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http://dx.doi.org/10.1111/bjh.16729DOI Listing

Safety and Efficacy of Blue Light Laser Treatment in Hereditary Hemorrhagic Telangiectasia.

Lasers Surg Med 2020 Jun 23. Epub 2020 Jun 23.

Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Munich, Marchioninistr. 15, Munich, 81377, Germany.

Background And Objectives: Hereditary hemorrhagic telangiectasia (HHT) is a hereditary condition that is associated with arteriovenous malformations. A common site for these malformations is the nasal mucosa, which is associated with severe epistaxis and debilitation for affected patients. We evaluated the efficacy and safety of blue light laser technology in treating these endonasal manifestations in a retrospective chart analysis. Read More

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http://dx.doi.org/10.1002/lsm.23289DOI Listing

Hemorrhagic tonsillitis in an infant: A case report.

Int J Pediatr Otorhinolaryngol 2020 Jun 14;136:110190. Epub 2020 Jun 14.

Division of Pediatric Otolaryngology Head and Neck Surgery, Connecticut Children's, 282 Washington Street, Hartford, CT 06106, United States. Electronic address:

This case report describes a case of severe hemorrhagic tonsillitis in a nine month-old child who suffered significant amount of blood loss and was emergently taken to operating room for control of hemorrhage. The child was brought to emergency room by mom after noticing blood around child's mouth and nose and a subsequent episode of hematemesis having awoken from sleep. Initial impression was bleeding secondary to epistaxis however a thorough bedside otolaryngology exam including flexible rhinolaryngoscopy ruled this out. Read More

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http://dx.doi.org/10.1016/j.ijporl.2020.110190DOI Listing

Arachnoid prolapse in endoscopic transsphenoidal surgery of pituitary adenoma, technical note.

Br J Neurosurg 2020 Jun 22:1-7. Epub 2020 Jun 22.

Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

An arachnoid prolapse after endoscopic transsphenoidal surgery for a pituitary adenoma is an uncommon, but important, phenomenon which should be managed. We have evaluated the efficacy of a new simple technique to correct the prolapsed arachnoid following endoscopic surgery of pituitary adenomas. A total of 1352 patients with pituitary adenomas, 24-76 years old, who underwent full endoscopic transsphenoidal surgeries between February 2014 and February 2019 in Erfan and Loghman Hakim hospitals. Read More

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http://dx.doi.org/10.1080/02688697.2020.1779178DOI Listing
June 2020
0.947 Impact Factor

In-Office KTP Laser for Treating Hereditary Hemorrhagic Telangiectasia-Associated Epistaxis.

Laryngoscope 2020 Jun 18. Epub 2020 Jun 18.

Division of Rhinology, Department of Otolaryngology-Head and Neck Surgery, St. Michael's Hospital, Unity Health Toronto, University of Toronto, Toronto, Ontario, Canada.

Objective: To evaluated the efficacy and safety of in-office potassium titanyl phosphate (KTP) laser treatment for the management of epistaxis in hereditary hemorrhagic telangiectasia (HHT) patients.

Methods: A retrospective case series of all HHT patients over age of 18 who underwent in-office KTP laser treatment from July 1, 2017 to December 31, 2019 was performed. The primary outcome measure was the epistaxis severity score (ESS) pre- and post-procedure. Read More

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http://dx.doi.org/10.1002/lary.28824DOI Listing

Device-related epistaxis risk: continuous-flow left ventricular assist device-supported patients.

Eur Arch Otorhinolaryngol 2020 Jun 15. Epub 2020 Jun 15.

Department of Cardiovascular Surgery, Faculty of Medicine, Baskent University, Ankara, 06490, Turkey.

Background: The aim of this study was to analyze the effect of device-dependent factors on epistaxis episodes comparing patients supported with a continuous-flow left ventricular assist device (CF-LVAD) to patients under the same antithrombotic therapy.

Methods: Patients who underwent CF-LVAD between 2012 and 2018 were reviewed retrospectively from the institutionally adopted electronic database. Patients who underwent mitral valve replacement (MVR) surgery receiving the same anticoagulant and antiaggregant therapy were included as a control group. Read More

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http://dx.doi.org/10.1007/s00405-020-06127-zDOI Listing

SMAD4 mutation and the combined juvenile polyposis and hereditary hemorrhage telangiectasia syndrome: a single center experience.

Int J Colorectal Dis 2020 Jun 15. Epub 2020 Jun 15.

Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN, USA.

Purpose: Mutations of the SMAD4 gene can result in a distinct syndrome with combined clinical features of both juvenile polyposis syndrome (JPS) and hereditary hemorrhagic telangiectasia (HHT). Even though it is known that patients with the overlap syndrome are at increased risk for colorectal malignancies and bleeding, the outcomes of this patient population have not been extensively studied.

Methods: Retrospective study aiming to describe the phenotype and clinical outcomes of patients with genetically confirmed JP-HHT combined syndrome in a single large tertiary center in North America. Read More

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http://dx.doi.org/10.1007/s00384-020-03670-3DOI Listing

Role of Endoscopic Internal Maxillary Artery Ligation in Intractable Idiopathic Epistaxis.

Indian J Otolaryngol Head Neck Surg 2020 Jun 8;72(2):228-233. Epub 2020 Jan 8.

Department of Otorhinolaryngology and Head and Neck Surgery, Pushpagiri Institute of Medical Sciences and Research Centre, Tiruvalla, 689101 India.

The protocols for managing intractable idiopathic epistaxis have evolved with advances in endoscopic techniques. Transnasal endoscopic sphenopalatine artery ligation (TESPAL) has been the treatment of choice for idiopathic intractable epistaxis. If TESPAL fails, transantral ligation of internal maxillary artery (IMA) used to be the dictum along with radiological interventions. Read More

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http://dx.doi.org/10.1007/s12070-020-01788-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276470PMC

Primary Sinonasal Lymphoma: A Rare Cause of Cranial Neuropathies.

Cureus 2020 May 15;12(5):e8135. Epub 2020 May 15.

Medicine/Hematology, State University of New York (SUNY) Upstate Medical University, Syracuse, USA.

Primary sinonasal lymphomas are a rare type of non-Hodgkin lymphoma (NHL) with an overall incidence of about 1% of all head and neck cancers. Diffuse large B-cell lymphoma (DLBCL) is the most common type of NHL and it most commonly occurs in elderly men. The diagnosis of such a lymphoma is difficult because of its varied presentation, which usually occurs late after a significant mass effect has taken place. Read More

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http://dx.doi.org/10.7759/cureus.8135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294899PMC

Dieulafoy's Lesion of the Nasal Mucosa: A Case of Recurrent Epistaxis From Submucosal Arterial Malformation.

OTO Open 2020 Apr-Jun;4(2):2473974X20927001. Epub 2020 May 20.

Department of Otolaryngology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

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http://dx.doi.org/10.1177/2473974X20927001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249568PMC

Outcome of a dog undergoing definitive-intent intensity-modulated radiation therapy for an intranasal ganglioneuroma.

Vet Radiol Ultrasound 2020 Jun 15. Epub 2020 Jun 15.

Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan.

An 11-year-old intact male Shiloh Shepherd was presented for evaluation of epistaxis, decreased nasal airflow, and destructive caudal nasal lesion identified using CT. Histopathologic evaluation of the nasal mass was consistent with a ganglioneuroma. The dog was treated with 10 × 4. Read More

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http://dx.doi.org/10.1111/vru.12877DOI Listing

Intranasal Corticosteroid Therapy: Systematic Review and Meta-analysis of Reported Safety and Adverse Effects in Adults.

Otolaryngol Head Neck Surg 2020 Jun 16:194599820931455. Epub 2020 Jun 16.

Department of Otolaryngology Head & Neck Surgery, Mayo Clinic in Arizona, Phoenix, Arizona, USA.

Objectives: To address concerns related to the safety profile of both Food and Drug Administration (FDA)-approved and non-FDA-approved intranasal corticosteroid (INCS) use in the adult population.

Data Source: Systematic review of MEDLINE, PubMed, and EMBASE databases using a comprehensive search strategy including all INCS formulations and adverse events. The study design was developed using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Read More

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http://dx.doi.org/10.1177/0194599820931455DOI Listing

Effect of continuous positive airway pressure treatment on permeability, inflammation and mucus production of human epithelial cells.

ERJ Open Res 2020 Apr 8;6(2). Epub 2020 Jun 8.

Woolcock Institute of Medical Research, University of Sydney, Sydney, Australia.

Continuous positive airway pressure (CPAP) therapy is the gold standard treatment for obstructive sleep apnoea, which affects millions of people worldwide. However, this therapy normally results in symptoms such as dryness, sneezing, rhinorrhoea, post-nasal drip, nasal congestion and epistaxis in the upper airways. Using bronchial epithelial (Calu-3) and nasal epithelial (RPMI 2650) cells in an respiratory model, this study, for the first time, investigates the effect of CPAP positive pressure on the human respiratory epithelial mechanisms that regulate upper airways lubrication characteristics. Read More

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http://dx.doi.org/10.1183/23120541.00327-2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276533PMC

Clinical predictors of significant intracranial computed tomography scan findings in adults experiencing headache disorder.

Pan Afr Med J 2020 19;35:81. Epub 2020 Mar 19.

Faculty of Medicine and Biomedical Sciences, The University of Yaounde 1, Yaounde, Cameroon.

Introduction: Radiological assessments for adult headache disorder show significant intracranial findings in 2.5% to 10% of performed computed tomography scans (CT-scans), leading to an overuse consideration for CT-scan requests by physicians in headache-experiencing patients. Therefore, we undertook this study in order to determine predictors of significant intracranial CT-scan findings in adults experiencing headache disorder; in order to help physicians better select patients who need imaging, which would subsequently decrease the costs of headache disorder management and the useless irradiation rates. Read More

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http://dx.doi.org/10.11604/pamj.2020.35.81.16041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250222PMC

[Congenital factor Ⅶ deficiency: a retrospective analysis of 43 cases].

Zhonghua Xue Ye Xue Za Zhi 2020 May;41(5):394-398

State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.

To explore the pathogenesis, clinical characteristics, laboratory findings, diagnosis, treatment, and prognosis of congenital factor Ⅶ (FⅦ) deficiency. Clinical data of 43 patients with congenital FⅦ deficiency diagnosed from April 1999 to September 2019 were retrospectively analyzed. There were 27 females and 16 males. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2020.05.006DOI Listing

3D-printable headlight face shield adapter. Personal protective equipment in the COVID-19 era.

Am J Otolaryngol 2020 Jun 1:102576. Epub 2020 Jun 1.

Photonics Engineering Group, Universidad de Cantabria, Santander, Spain. Electronic address:

The coronavirus SARS-CoV-2 (COVID19) pandemic has pushed health workers to find creative solutions to a global shortage of personal protection equipment (PPE). 3D-printing technology is having an essential role during the pandemic providing solutions for this problem, for instance, modifying full-face snorkel masks or creating low-cost face shields to use as PPE (Ishack and Lipner, 2020 [1]). Otolaryngologists are at increased occupational risk to COVID19 infection due to the exposure to respiratory droplets and aerosols, especially during the routine nose and mouth examinations where coughing and sneezing happen regularly (Rna et al. Read More

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http://dx.doi.org/10.1016/j.amjoto.2020.102576DOI Listing

Review of Pharmacological Strategies with Repurposed Drugs for Hereditary Hemorrhagic Telangiectasia Related Bleeding.

J Clin Med 2020 Jun 6;9(6). Epub 2020 Jun 6.

Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas (CSIC), 9 Ramiro de Maeztu Street, 28040 Madrid, Spain.

The diagnosis of hereditary hemorrhagic telangiectasia (HHT) is based on the Curaçao criteria: epistaxis, telangiectases, arteriovenous malformations in internal organs, and family history. Genetically speaking, more than 90% of HHT patients show mutations in or genes, both belonging to the TGF-β/BMP9 signaling pathway. Despite clear knowledge of the symptoms and genes of the disease, we still lack a definite cure for HHT, having just palliative measures and pharmacological trials. Read More

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http://dx.doi.org/10.3390/jcm9061766DOI Listing

The blood supply of the inferior nasal concha (turbinate): a cadaveric anatomical study.

Anat Sci Int 2020 Jun 8. Epub 2020 Jun 8.

Department of Anatomy, Faculty of Medicine, Hacettepe Univesity, Sihhiye, 06100, Ankara, Turkey.

The blood supply of the lateral nasal wall acquires a great deal of interest for many reasons especially for the treatment of clinical conditions such as epistaxis that sometimes needs surgical interventions and endoscopic sinus and skull base surgeries that requires a good choice of endonasal flaps including inferior nasal concha (commonly named as inferior turbinate by clinicians) flap to close the dural defects. Successful treatment of epistaxis and closure of such defects depends on detailed anatomical knowledge of lateral nasal wall vasculature and a vital flap with good blood supply, respectively. Because of these we aimed to study the blood supply of inferior turbinate, regarding the sources and courses of the blood vessels. Read More

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http://dx.doi.org/10.1007/s12565-020-00552-0DOI Listing

A Morphometric Analysis of Platelet Dense Granules of Patients with Unexplained Bleeding: A New Entity of Delta-Microgranular Storage Pool Deficiency.

J Clin Med 2020 Jun 4;9(6). Epub 2020 Jun 4.

Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY 14642, USA.

One thousand and eighty patients, having prolonged bleeding times, frequent epistaxis, menorrhagia or easy bruising or other bleeding manifestations, and excluding those with von Willebrand's disease, were evaluated for platelet dense granule deficiency. The mean diameter of platelet dense granules was determined for all patients using image analysis. Four hundred and ninety-nine had "classic" dense (delta) granule storage pool deficiency (δ-SPD). Read More

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http://dx.doi.org/10.3390/jcm9061734DOI Listing

Hereditary Haemorrhagic Telangiectasia (HHT) Marked by ACVRL1C1120T Variant Displays Hypopigmented Naevi and Frequent Bleeding Episodes if CYP2C9 Co-Mutated: Clinical Notes & Rationale of Patient Registry.

Folia Biol (Praha) 2020 ;66(1):1-6

Biocev, First Faculty of Medicine, Charles University, Vestec, Czech Republic.

Hereditary haemorrhagic telangiectasia (HHT) exhibits considerable phenotypic heterogeneity. Therefore, precise mutation screening and evaluation of patient risk must be determined in every HHT family. We present an HHT-2 case with an initial life-threatening bleeding episode that led to identification of a relatively large HHT family. Read More

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January 2020

Looking under the hood of "the Cadillac of cancers:" radioactive iodine-related craniofacial side effects among patients with thyroid cancer.

J Cancer Surviv 2020 Jun 6. Epub 2020 Jun 6.

Department of Oncology, Georgetown Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.

Purpose: Despite having a generally favorable prognosis, differentiated thyroid cancer is known to have a significant, long-term impact on the quality of life of survivors. We wished to investigate short- and long-term effects among thyroid cancer survivors following radioactive iodine therapy.

Methods: We conducted eight focus groups (N = 47) to understand patients' experiences of short- and long-term effects after radioactive iodine treatment and the impact these treatment-related side effects had on patients' quality of life. Read More

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http://dx.doi.org/10.1007/s11764-020-00897-5DOI Listing

'Self-collected upper respiratory tract swabs for COVID-19 test': A feasible way to increase overall testing rate and conserve resources in South Africa.

Afr J Prim Health Care Fam Med 2020 May 28;12(1):e1-e4. Epub 2020 May 28.

Division of Family Medicine and Primary Care, Faculty of Health Sciences, Stellenbosch University, Cape Town, South Africa; and, Ceres Hospital, Cape Winelands Health District, Department of Health, Ceres.

Disparity in the testing rate of SARS-CoV-2 amongst different countries and regions is a very big challenge in understanding the COVID-19 pandemic. Although some developed countries have a very high testing rate and subsequently a high number of confirmed cases, less developed countries have a low testing rate and an illusive positivity rate. Collection of the upper respiratory specimen is not often comfortable. Read More

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http://dx.doi.org/10.4102/phcfm.v12i1.2445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300941PMC

Simultaneous Septal Perforation and Deviation Repair with a Chondromucosal Transposition Flap.

OTO Open 2020 Apr-Jun;4(2):2473974X20924332. Epub 2020 May 21.

Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Hospital, Baltimore, Maryland, USA.

Nasal septal perforations can cause issues of epistaxis, whistling, crusting, saddle deformity, and obstruction, which motivate patients to seek surgical repair. Numerous methods of septal perforation repair have been described, with surgical success rates ranging from 52% to 100%, but few studies address situations with concomitant septal deviation. In treating patients with septal perforation and deviation, both issues should be addressed for optimal outcomes. Read More

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http://dx.doi.org/10.1177/2473974X20924332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243391PMC

Traumatic Nonmissile Penetrating Transnasal Anterior Skull Base Fracture and Brain Injury with Cerebrospinal Fluid Leak: Intraoperative Leak Detection and an Effective Reconstruction Procedure for a Localized Skull Base Defect Especially After Coronavirus Disease 2019 Outbreak.

World Neurosurg 2020 Jun 1;140:166-172. Epub 2020 Jun 1.

Department of Neuorsurgery, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Niigata, Japan.

Background: Cerebrospinal fluid (CSF) leakage after penetrating skull base injury is relatively rare compared with close head injuries involving skull base fractures.

Case Description: We report the case of a 65-year-old man who had presented with epistaxis and serous rhinorrhea. When he had fallen to the ground near his bee boxes, a garden pole had poked into his right nostril. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.05.236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263210PMC

Application of endoscopic sinus surgery in hemostasis for epistaxis.

J Biol Regul Homeost Agents 2020 Mar-Apr;34(2):655-657

Department of Otolaryngology Head and Neck Surgery, Aerospace Center Hospital, Beijing, China.

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http://dx.doi.org/10.23812/19-341-L-58DOI Listing

Early therapy with corticosteroid and surfactant for acute idiopathic pulmonary hemorrhage in infants: Two case reports.

Medicine (Baltimore) 2020 May;99(21):e20281

Rationale: Acute idiopathic pulmonary hemorrhage (AIPH) in infants is a rare condition, and a clear treatment protocol has not yet been established.

Patient Concerns: We report 2 infant cases of AIPH in a 3-month-old male and a 1-month-old female, who presented at an emergency room with epistaxis and respiratory distress. Both were immediately intubated, which revealed a bloody intratracheal aspirate. Read More

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http://dx.doi.org/10.1097/MD.0000000000020281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249888PMC

A Simple and Safe Approach for Maxillary Sinus Augmentation with the Advanced Surgical Guide.

Int J Environ Res Public Health 2020 May 27;17(11). Epub 2020 May 27.

Department of Oral and Maxillofacial Surgery, Hallym University College of Medicine, Anyang 14068, Korea.

Objective: The development of digital dentistry has contributed to the astonishing advancement of implant dentistry. Furthermore, digital technology is expected to be applied extensively to sinus augmentation, which is an advanced technique for implant surgery. This study introduces a simple method for a safer and more precise lateral window opening for sinus augmentation using a navigation program. Read More

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http://dx.doi.org/10.3390/ijerph17113785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313061PMC

Management of Upper Airway Bleeding in COVID-19 Patients on Extracorporeal Membrane Oxygenation.

Laryngoscope 2020 May 29. Epub 2020 May 29.

Department of Otorhinolaryngology - Head and Neck Surgery, Rush University Medical Center, Chicago, IL, 60612.

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http://dx.doi.org/10.1002/lary.28846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283688PMC

Intranasal lobular capillary hemangioma: A series of five cases.

Respir Med Case Rep 2020 11;30:101073. Epub 2020 May 11.

Division of Otolaryngology - Head and Neck Surgery, Department of Surgery, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.

Background: Lobular capillary hemangiomas (LCH) are acquired benign vascular lesions of the skin and mucous membranes mostly affecting the head and neck region. Involvement of the nasal cavity is extremely rare and can manifest as epistaxis and nasal obstruction.

Case Series: In this case series, we present five cases of intranasal LCH. Read More

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http://dx.doi.org/10.1016/j.rmcr.2020.101073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236058PMC

An international survey to evaluate systemic bevacizumab for chronic bleeding in hereditary haemorrhagic telangiectasia.

Haemophilia 2020 May 20. Epub 2020 May 20.

Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA.

Introduction: Systemic bevacizumab is a novel targeted therapy for severe epistaxis and chronic gastrointestinal bleeding in hereditary haemorrhagic telangiectasia (HHT), but published data are very limited.

Aim: We conducted a survey-based study to characterize current treatment practices and physician-reported safety and effectiveness of systemic bevacizumab for bleeding in (HHT).

Methods: A 27-item survey was sent to physician centre directors of 31 International HHT Centers of Excellence. Read More

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http://dx.doi.org/10.1111/hae.14034DOI Listing

Serious Hemorrhagic Complications After Successful Treatment of Hematopoietic Stem Cell Transplantation-Associated Thrombotic Microangiopathy With Defibrotide in Pediatric Patient With Myelodysplastic Syndrome.

Front Pediatr 2020 5;8:155. Epub 2020 May 5.

Hematopoietic Stem Cell Transplantation, Dmitry Rogachev National Medical Center of Pediatric Hematology, Oncology and Immunology, Moscow, Russia.

Transplant-associated thrombotic microangiopathy (TAM) is a life-threatening complication of hematopoietic stem cell transplantation (HSCT). There is some evidence of endothelial injury playing a significant role in TAM development. The efficacy of defibrotide was demonstrated for prophylaxis and treatment of another HSCT-associated endothelial damage syndrome-liver veno-occlusive disease. Read More

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http://dx.doi.org/10.3389/fped.2020.00155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214790PMC

Topical Tranexamic Acid for Hemostasis of an Oral Bleed in a Patient on a Direct Oral Anticoagulant.

Clin Pract Cases Emerg Med 2020 May 27;4(2):146-149. Epub 2020 Mar 27.

Yale School of Medicine, Department of Emergency Medicine, New Haven, Connecticut.

Introduction: Tranexamic acid (TXA) is an antifibrinolytic agent currently approved and utilized in the treatment of dysfunctional uterine bleeding, traumatic extracranial hemorrhage, anterior epistaxis, and dental procedures on patients with hemophilia. There is a paucity of literature evaluating the use of TXA for hemostasis in patients on direct oral anticoagulants (DOACs).

Case Report: Our patient, a 72 year-old male on rivaroxaban, presented with persistent bleeding following a punch biopsy of the buccal mucosa. Read More

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http://dx.doi.org/10.5811/cpcem.2020.1.45326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219988PMC

Crying blood: Association of Valsalva and Hemolacria.

Orbit 2020 May 19. Epub 2020 May 19.

Department of Ophthalmology, Byers Eye Institute at Stanford University, Palo Alto, California, USA.

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http://dx.doi.org/10.1080/01676830.2020.1768562DOI Listing

Algorithm-Based Pediatric Otolaryngology Management During the COVID-19 Global Pandemic: A Children's Hospital of Philadelphia Clinical Consensus.

Otolaryngol Head Neck Surg 2020 Jul 19;163(1):25-37. Epub 2020 May 19.

Division of Otolaryngology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

Objective: The coronavirus disease 2019 (COVID-19) pandemic requires clinicians to explore alternatives to routine patient management. Otolaryngologists caring for children commonly depend on physical examination, laboratory data, and ambulatory surgical procedures. Limiting patient care, mindful allocation of resources, and concern for safety have challenged all aspects of our health care system. Read More

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http://dx.doi.org/10.1177/0194599820923633DOI Listing

Use of Purastat, a novel haemostatic matrix based on self-assembling peptides in the prevention of nasopharyngeal adhesion formation.

Int J Surg Case Rep 2020 8;70:227-229. Epub 2020 May 8.

Department of Otolaryngology, Head and Neck Surgery, Westmead Hospital, Westmead, NSW, Australia; Sydney Medical School, University of Sydney, Camperdown, NSW, Australia.

Introduction: Purastat is a novel haemostatic agent that has recently been used effectively in nasal procedures, specifically in functional endoscopic endonasal surgery in the prevention of post-operative epistaxis while minimising adhesion formation. This study presents a case of successful application of Purastat following division of a nasopharyngeal/palatal stenosis following radiotherapy.

Presentation Of Case: A 49-year-old male developed severe nasopharyngeal stenosis following concurrent chemoradiotherapy with curative intent a HPV positive base of tongue squamous cell carcinoma. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.04.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231812PMC

Neuroangiography: Review of Anatomy, Periprocedural Management, Technique, and Tips.

Semin Intervent Radiol 2020 Jun 14;37(2):166-174. Epub 2020 May 14.

Department of Neurosurgery, University of Colorado School of Medicine, Aurora, Colorado.

Neuroangiography (NA) is a minimally invasive procedure used to diagnose patients with neurovascular diseases. Noninvasive imaging has improved dramatically in recent years and is utilized more frequently; however, further evaluation with NA is still required in certain cases. NA indications include intracranial (cerebral aneurysms, arteriovenous malformations, dural arteriovenous fistula, cerebral vasculitis, cerebral vasospasm, ischemic stroke, nontraumatic subarachnoid hemorrhage, intracerebral hemorrhage, Moyamoya, vein of Galen malformation, intracranial tumors, and pseudotumor cerebri) and extracranial (internal and common carotid artery stenosis, vertebral artery stenosis, carotid artery blowout, vertebral artery blowout, epistaxis, oropharyngeal bleeding, and carotid body tumor) pathologies which can help with diagnosis and potential subsequent endovascular treatment. Read More

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http://dx.doi.org/10.1055/s-0040-1709171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224980PMC

Endovascular Treatment of Epistaxis.

Authors:
Joan C Wojak

Semin Intervent Radiol 2020 Jun 14;37(2):150-156. Epub 2020 May 14.

Department of Radiology, Our Lady of Lourdes Regional Medical Center, Lafayette, Louisiana.

Epistaxis is not uncommon, with up to 60% of the population suffering from at least one episode in their lifetime and as many as 6% presenting for medical attention. An analysis of emergency room (ER) visits in the United States between 2009 and 2011 identified 1.2 million encounters for epistaxis, accounting for 0. Read More

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http://dx.doi.org/10.1055/s-0040-1709156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224976PMC

Inflammatory Pseudotumor in the Nasal Cavity and Sinuses: A Case Report and Associated Literature Review.

Ear Nose Throat J 2020 May 18:145561320924489. Epub 2020 May 18.

Department of Otolaryngology, Head and Neck Surgery, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, People's Republic of China.

Inflammatory pseudotumor (IP) is a clinically aggressive but histologically benign condition of unknown cause. It rarely appears in the nasal cavity and sinuses. Here, we describe a 24-year-old female with the main symptom of right nasal obstruction. Read More

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http://dx.doi.org/10.1177/0145561320924489DOI Listing

Tracheal Irrigation Without Bronchoscopy as an Alternative Emergent Treatment of Blood Aspiration.

J Emerg Med 2020 May 13;58(5):e223-e226. Epub 2020 May 13.

Department of Emergency Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea.

Background: Tracheobronchial foreign body aspiration can cause mild symptoms but may also become dangerous enough to cause death. Bronchoscopy is the first choice for the diagnosis and the removal of aspirated foreign bodies. So, when bronchoscopy is not available, the situation might get challenging. Read More

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http://dx.doi.org/10.1016/j.jemermed.2020.04.011DOI Listing

Prevalence of postoperative secondary bleeding and its relationship with intraoperative massive bleeding in patients undergoing orthognathic surgery.

J Stomatol Oral Maxillofac Surg 2020 May 13. Epub 2020 May 13.

Department of Oral and Maxillofacial Surgery, Istanbul Medipol University, Faculty of Dentistry, Atatürk Bulvarı No: 27 Fatih, 34083 Istanbul, Turkey.

Introduction: Postoperative bleeding after orthognathic surgery is a rare but life-threatening complication. Maxillary surgery is the main cause of bleeding, after which excessive epistaxis can occur until the 10th postoperative day. Due to the risk of secondary bleeding, the patient discharge process may be complicated for both the patient and clinician. Read More

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http://dx.doi.org/10.1016/j.jormas.2020.05.002DOI Listing

Lateral rhinotomy and coblation for treatment of a nasal hamartoma in a dog.

J Am Vet Med Assoc 2020 Jun;256(11):1257-1261

Case Description: A 4-year-old spayed female French Bulldog was referred for treatment of a suspected right-sided nasal angiofibroma associated with a 4-month history of unilateral nasal discharge and stertor.

Clinical Findings: The dog appeared healthy other than right-sided mucoid debris and decreased airflow through the right naris. The dog was anesthetized, and a large intranasal mass was observed obstructing the right nasal passage and abutting the nasal septum. Read More

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http://dx.doi.org/10.2460/javma.256.11.1257DOI Listing