3,689 results match your criteria Epileptiform Discharges


Alternative Diagnosis of Epilepsy in Children Without Epileptiform Discharges Using Deep Convolutional Neural Networks.

Int J Neural Syst 2019 Jan 8:1850060. Epub 2019 Jan 8.

§ Department of Computer and Communication, National Pingtung University, 51 Min Sheng East Road, Pingtung, 90003, Taiwan.

Numerous nonepileptic paroxysmal events, such as syncope and psychogenic nonepileptic seizures, may imitate seizures and impede diagnosis. Misdiagnosis can lead to mistreatment, affecting patients' lives considerably. Electroencephalography is commonly used for diagnosing epilepsy. Read More

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http://dx.doi.org/10.1142/S0129065718500600DOI Listing
January 2019

Can continual interictal epileptiform discharges cause persistent memory disturbances?

Psychogeriatrics 2019 Feb 18. Epub 2019 Feb 18.

Department of Psychiatry, Shinjuku Shinkei Clinic, Tokyo, Japan.

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http://dx.doi.org/10.1111/psyg.12429DOI Listing
February 2019

Epilepsy, depression, and growth hormone.

Epilepsy Behav 2019 Feb 14. Epub 2019 Feb 14.

Clinical and Translational Science Center, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, United States of America.

Depression affects a large proportion of patients with epilepsy, and is likely due in part to biological mechanism. Hormonal dysregulation due to the disruptive effects of seizures and interictal epileptiform discharges on the hypothalamic-pituitary-adrenal axis likely contributes to high rates of depression in epilepsy. This paper reviews the largely unexplored role of neuroendocrine factors in epilepsy-related depression, focusing on Growth Hormone (GH). Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.01.022DOI Listing
February 2019

Assessing the localization accuracy and clinical utility of electric and magnetic source imaging in children with epilepsy.

Clin Neurophysiol 2019 Jan 31;130(4):491-504. Epub 2019 Jan 31.

Laboratory of Children's Brain Dynamics, Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Fetal-Neonatal Neuroimaging Developmental Science Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

Objective: To evaluate the accuracy and clinical utility of conventional 21-channel EEG (conv-EEG), 72-channel high-density EEG (HD-EEG) and 306-channel MEG in localizing interictal epileptiform discharges (IEDs).

Methods: Twenty-four children who underwent epilepsy surgery were studied. IEDs on conv-EEG, HD-EEG, MEG and intracranial EEG (iEEG) were localized using equivalent current dipoles and dynamical statistical parametric mapping (dSPM). Read More

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http://dx.doi.org/10.1016/j.clinph.2019.01.009DOI Listing
January 2019

Quality of life and psychological dysfunction in traumatized and nontraumatized patients with psychogenic nonepileptic seizures (PNES).

Epilepsy Behav 2019 Feb 12;92:341-344. Epub 2019 Feb 12.

CAPHRI School for Public Health and Primary Care, Department of Health Services Research, Maastricht University, Maastricht, the Netherlands; Centre for Economic Evaluation, Trimbos Institute, Netherlands Institute of Mental Health and Addiction, Utrecht, the Netherlands.

Objectives: Psychogenic nonepileptic seizures (PNES) have the appearance of epileptic seizures, yet show no epileptiform discharges in the brain. The quality of life (QOL) in patients with PNES is reportedly low and trauma eems to be a relevant risk factor. The objective of this study was to examine the difference between measures of (epilepsy-specific) QOL (Quality of Life in Epilepsy Inventory; QOLIE-31p) and psychological dysfunction (trauma symptom inventory; TSI) between patients with diagnosed PNES with self-reported trauma and those without self-reported trauma. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15255050183095
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http://dx.doi.org/10.1016/j.yebeh.2019.01.024DOI Listing
February 2019
5 Reads

Functional brain connectivity in electrical status epilepticus in sleep.

Epileptic Disord 2019 Feb 15. Epub 2019 Feb 15.

Department of Neurological Sciences, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.

Electrical status epilepticus in sleep (ESES) is an age-related, self-limited epileptic encephalopathy. The syndrome is characterized by cognitive and behavioral abnormalities and a specific EEG pattern of continuous spikes and waves during slow-wave sleep. While spikes and sharp waves are known to result in transient cognitive impairment during learning and memory tasks performed during the waking state, the effect of epileptiform discharges during sleep on cognition and behavior is unclear. Read More

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http://dx.doi.org/10.1684/epd.2019.1027DOI Listing
February 2019

Source localization of epileptiform discharges in childhood absence epilepsy using a distributed source model: a standardized, low-resolution, brain electromagnetic tomography (sLORETA) study.

Neurol Sci 2019 Feb 12. Epub 2019 Feb 12.

Department of Internal Medicine, Sanggye Paik Hospital, College of Medicine, Inje University, Seoul, Republic of Korea.

Localizing the source of epileptiform discharges in generalized epilepsy has been controversial for the past few decades. Recent neuroimaging studies have shown that epileptiform discharges in generalized epilepsy can be localized to a particular region. Childhood absence epilepsy (CAE) is the most common generalized epilepsy in childhood and is considered the prototype of idiopathic generalized epilepsy (IGE). Read More

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http://dx.doi.org/10.1007/s10072-019-03751-4DOI Listing
February 2019

The Detection of the Negative Effects of Interictal Epileptiform Discharges on Cognition: An Event-Related Potential Study.

J Nerv Ment Dis 2019 Feb 8. Epub 2019 Feb 8.

Department of Neurology, Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, Jilin, People's Republic of China.

Evidence from a neuropsychological test revealed that interictal epileptiform discharges (IEDs) may have significant impact on cognitive performance. Sometimes, neuropsychological tests may not be sensitive to detection of mild cognitive changes. We applied P300 and mismatch negativity (MMN) to detect mild cognitive changes caused by small amount of IEDs. Read More

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http://dx.doi.org/10.1097/NMD.0000000000000945DOI Listing
February 2019

Stridor as initial presentation of rolandic epilepsy.

Int J Pediatr Otorhinolaryngol 2019 Jan 30;119:183-184. Epub 2019 Jan 30.

Department of Otorhinolaryngology, Centro Hospitalar Vila Nova de Gaia/Espinho, Unidade 1, Serviço de Otorrinolaringologia, Pavilhão Feminino, Rua Conceição Fernandes, 4434-502, Vila Nova de Gaia, Portugal.

The authors present the case of a 5-year-old girl referred to our institution due to several episodes of nocturnal stridor with ocular retroversion and parental notion of apnea. She has been previously submitted to adenotonsillectomy. Due to symptoms worsening she was referred to our hospital. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01655876193005
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http://dx.doi.org/10.1016/j.ijporl.2019.01.040DOI Listing
January 2019
1 Read

Inhibition and oscillations in the human brain tissue in vitro.

Neurobiol Dis 2019 Feb 8;125:198-210. Epub 2019 Feb 8.

Clinical Neurophysiology Department, Pitie-Salpetriere Hospital, Sorbonne Université, APHP, Paris 75013, France; Neuroglial Interactions in Cerebral Physiopathology, Center for Interdisciplinary Research in Biology, Collège de France, CNRS UMR 7241, INSERM U1050, Labex Memolife, PSL Research University, Paris 75005, France. Electronic address:

Oscillations represent basic operational modes of the human brain. They reflect local field potential activity generated by the laminar arrangement of cell-type specific microcircuits interacting brain-wide under the influence of neuromodulators, endogenous processes and cognitive demands. Under neuropathological conditions, the spatiotemporal structure of physiological brain oscillations is disrupted as recorded by electroencephalography and event-relate potentials. Read More

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http://dx.doi.org/10.1016/j.nbd.2019.02.006DOI Listing
February 2019
1 Read

Delayed creatine supplementation counteracts reduction of GABAergic function and protects against seizures susceptibility after traumatic brain injury in rats.

Prog Neuropsychopharmacol Biol Psychiatry 2019 Feb 8;92:328-338. Epub 2019 Feb 8.

Programa de Pós-Graduação em Farmacologia, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil; Programa de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil; Laboratório de Bioquímica do Exercício, Programa de Pós-Graduação em Educação Física, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil. Electronic address:

Traumatic brain injury (TBI) is a devastating disease frequently followed by behavioral disabilities including post-traumatic epilepsy (PTE). Although reasonable progress in understanding its pathophysiology has been made, treatment of PTE is still limited. Several studies have shown the neuroprotective effect of creatine in different models of brain pathology, but its effects on PTE is not elucidated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02785846183081
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http://dx.doi.org/10.1016/j.pnpbp.2019.02.004DOI Listing
February 2019
3 Reads

Epileptiform EEG patterns during different techniques of induction of general anaesthesia with sevoflurane and propofol: a randomised trial.

Anaesthesiol Intensive Ther 2019 Feb 6. Epub 2019 Feb 6.

Department of Anaesthesiology and Intensive Therapy, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland, Plac Medyków 1,, 41-200 Sosnowiec, Poland.

Background: The aim of the study was to assess the influence of volatile induction of general anaesthesia with sevoflurane using two different techniques and intravenous anaesthesia with propofol on the possible presence of epileptiform electroencephalograph patterns during the induction of general anaesthesia.

Methods: Sixty patients (age 18-70 years) were recruited. Exclusion criteria included history of epilepsy, neurological or neurosurgical diseases, pre-existing EPs in initial EEG recordings, medication interfering with EEG patterns. Read More

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http://dx.doi.org/10.5603/AIT.a2019.0003DOI Listing
February 2019
1 Read

Cortical Layer and Spectrotemporal Architecture of Epileptiform Activity in a Mouse Model of Focal Cortical Malformation.

Front Neural Circuits 2019 22;13. Epub 2019 Jan 22.

Department of Zoology & Physiology, University of Wyoming, Laramie, WY, United States.

Our objective is to examine the layer and spectrotemporal architecture and laminar distribution of high-frequency oscillations (HFOs) in a neonatal freeze lesion model of focal cortical dysplasia (FCD) associated with a high prevalence of spontaneous spike-wave discharges (SWDs). Electrophysiological recording of local field potentials (LFPs) in control and freeze lesion animals were obtained with linear micro-electrode arrays to detect presence of HFOs as compared to changes in spectral power, signal coherence, and single-unit distributions during "hyper-excitable" epochs of anesthesia-induced burst-suppression (B-S). Result were compared to HFOs observed during spontaneous SWDs in animals during sleep. Read More

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http://dx.doi.org/10.3389/fncir.2019.00002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349724PMC
January 2019
1 Read

Electroencephalographic features associated with intermittent rhythmic delta activity.

Neurophysiol Clin 2019 Jan 31. Epub 2019 Jan 31.

Department of Neurology, Cerrahpasa School of Medicine, Istanbul University, Istanbul, Turkey.

Objective: To investigate the clinical importance of intermittent rhythmic delta activity (IRDA) in terms of accompanying electrophysiological findings on EEG and their association with IRDA.

Methods: We retrospectively assessed all EEG studies recorded in our institution from 2011 to 2017. Patients with intermittent rhythmic delta activity (IRDA) in EEGs were included. Read More

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http://dx.doi.org/10.1016/j.neucli.2019.01.036DOI Listing
January 2019

Similarities and differences between the interictal epileptiform discharges of green-spikes and red-spikes zones of human neocortex.

Authors:
Ruggero Serafini

Clin Neurophysiol 2019 Mar 19;130(3):396-405. Epub 2019 Jan 19.

Department of Neurology, University of Utah, Clinical Neuroscience Center, George E. Wahlen VA Medical Center, Salt Lake City, UT, USA. Electronic address:

Objective: This study looks for differences in the waveforms of interictal epileptiform discharges (IEDs) between cortices expressing only isolated discharges (green-spikes zones) vs those manifesting seizures (red-spikes zones): these can help to understand ictogenesis mechanisms and improve clinical decision in surgical epilepsy. Typical IEDs are triphasic, exhibiting in sequence: a negative-sharp-wave, a positive-baseline-shift and a negative-slow-wave. Negative-slow-waves are thought to reflect neurophysiological inhibition: their features at a focus' edge may reflect peripheral inhibition, a mechanism characterized in experimental models, curbing seizures' spread. Read More

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http://dx.doi.org/10.1016/j.clinph.2018.12.011DOI Listing

[Early electrophysiological consequences of dosed traumatic-brain injury in rats].

Zh Nevrol Psikhiatr Im S S Korsakova 2018 ;118(10. Vyp. 2):21-26

Institute of Higher Nervous Activity and Neurophysiology RAS, Moscow, Russia; Moscow Research and Clinical Center for Neuropsychiatry of the Healthcare Department, Moscow, Russia.

Aim: To analyze the pathological electrical activity during the acute period after traumatic brain injury (TBI) and to search for potential morphological correlates of this activity in the neocortex and hippocampus.

Material And Methods: The study was performed on male Sprague Dawley rats. TBI was modeled using a lateral hydrodynamic impact in the sensorimotor cortex area. Read More

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http://dx.doi.org/10.17116/jnevro201811810221DOI Listing
January 2018

[Rhythmic and periodic EEG patterns. Classification and clinical significance.]

Zh Nevrol Psikhiatr Im S S Korsakova 2018 ;118(10. Vyp. 2):9-20

Evdokimov Moscow State University of Medical Dentistry, Moscow, Russia; Sklifosovsky Research Institute of Emergency Medicine, Moscow, Russia.

The review presents the methodology of electroencephalography (EEG) background analysis, sporadic epileptiform discharges classification, and description of the rhythmic and periodic patterns in patients with primary and secondary brain damage. It describes the process of decision making in starting non-convulsive status epilepticus treatment of patients with EEG-verified non-convulsive status epilepticus and the signs of 'malignant' patterns indicating the irreversibility of brain injury. Read More

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http://dx.doi.org/10.17116/jnevro20181181029DOI Listing
January 2018
1 Read

Hippocampus and Insula Are Targets in Epileptic Patients With Glutamic Acid Decarboxylase Antibodies.

Front Neurol 2018 9;9:1143. Epub 2019 Jan 9.

Epilepsy Unit, Department of Neurology, Hospital Clinic i Provincial, Barcelona, Spain.

Antibodies to glutamic acid decarboxylase (GAD ab) have been found in patients with limbic encephalitis (LE) and chronic pharmacoresistant focal epilepsy (FE). The objectives of the study were to: (1) analyze the clinical and neuroimaging course of patients with FE+GAD ab, (2) compare these characteristics with a control group, and (3) describe the most affected cerebral areas with structural and functional imaging. Patients with FE + high titers of GAD ab and a follow-up of at least 5 years were selected. Read More

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http://dx.doi.org/10.3389/fneur.2018.01143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334555PMC
January 2019
2 Reads

Taurine potentiates the anticonvulsive effect of the GABA agonist muscimol and pentobarbital in the immature mouse hippocampus.

Epilepsia 2019 Jan 25. Epub 2019 Jan 25.

Institute of Physiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

Objective: The high incidence of epileptic seizures in neonates and their frequent refractoriness to pharmacologic therapies require identification of new therapeutical options. Therefore, we investigated whether the modulatory effect of taurine on γ-aminobutyric acid (GABA) receptors can enhance the anticonvulsive potential of the GABA receptor agonist muscimol and of the barbiturate pentobarbital.

Methods: We performed field potential recordings in in toto hippocampus preparations of immature (postnatal days 4-7) C57Bl/6 mouse pups. Read More

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http://dx.doi.org/10.1111/epi.14651DOI Listing
January 2019

Region-specific differences and areal interactions underlying transitions in epileptiform activity.

J Physiol 2019 Jan 25. Epub 2019 Jan 25.

Institute of Neuroscience, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.

Key Points: Local neocortical and hippocampal territories show different and sterotypical patterns of acutely evolving, epileptiform activity. Neocortical and entorhinal networks show tonic-clonic-like events, but the main hippocampal territories do not, unless it is relayed from the other areas. Transitions in the pattern of locally recorded epileptiform activity can be indicative of a shift in the source of pathological activity, and may spread through both synaptic and non-synaptic means. Read More

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http://dx.doi.org/10.1113/JP277267DOI Listing
January 2019
1 Read

Towards fast and reliable simultaneous EEG-fMRI analysis of epilepsy with automatic spike detection.

Clin Neurophysiol 2019 Mar 17;130(3):368-378. Epub 2018 Dec 17.

The Florey Institute of Neuroscience and Mental Health, Austin Campus, Melbourne, VIC, Australia; Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, VIC, Australia; Department of Neurology, Austin Health, Melbourne, VIC, Australia. Electronic address:

Objective: The process of manually marking up epileptic spikes for simultaneous electroencephalogram (EEG) and resting state functional MRI (rsfMRI) analysis in epilepsy studies is a tedious and subjective task for a human expert. The aim of this study was to evaluate whether automatic EEG spike detection can facilitate EEG-rsfMRI analysis, and to assess its potential as a clinical tool in epilepsy.

Methods: We implemented a fast algorithm for detection of uniform interictal epileptiform discharges (IEDs) in one-hour scalp EEG recordings of 19 refractory focal epilepsy datasets (from 16 patients) who underwent a simultaneous EEG-rsfMRI recording. Read More

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http://dx.doi.org/10.1016/j.clinph.2018.11.024DOI Listing

Transient Cognitive Impairment in Epilepsy.

Front Mol Neurosci 2018 7;11:458. Epub 2019 Jan 7.

NEST, Istituto Nanoscienze-CNR and Scuola Normale Superiore, Pisa, Italy.

Impairments of the dialog between excitation and inhibition (E/I) is commonly associated to neuropsychiatric disorders like autism, bipolar disorders and epilepsy. Moderate levels of hyperexcitability can lead to mild alterations of the EEG and are often associated with cognitive deficits even in the absence of overt seizures. Indeed, various testing paradigms have shown degraded performances in presence of acute or chronic non-ictal epileptiform activity. Read More

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http://dx.doi.org/10.3389/fnmol.2018.00458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330286PMC
January 2019
1 Read

Real-time effects of interictal spikes on hippocampus and amygdala functional connectivity in unilateral temporal lobe epilepsy: An EEG-fMRI study.

Epilepsia 2019 Feb 17;60(2):246-254. Epub 2019 Jan 17.

Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Objective: To explore the real-time effects of interictal epileptiform discharges (IEDs) on hippocampus and amygdala functional connectivity (FC) in unilateral temporal lobe epilepsy (TLE).

Methods: Patients with unilateral TLE were recruited and underwent simultaneous electroencephalography-functional magnetic resonance imaging (EEG-fMRI) scanning. Simultaneous EEG was used to define the prespike (10 s before spike) and postspike (10 s after spike) periods. Read More

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http://doi.wiley.com/10.1111/epi.14646
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http://dx.doi.org/10.1111/epi.14646DOI Listing
February 2019
7 Reads
4.571 Impact Factor

EEG in WNV Neuroinvasive Disease.

J Clin Neurophysiol 2019 Jan 21. Epub 2019 Jan 21.

Department of Neurology, Mayo Clinic, Scottsdale, AZ, U.S.A.

Purpose: Neuroinvasive West Nile virus (WNV) is rare, occurring in less than 1% of those infected, and may manifest as meningitis, encephalitis, and/or acute flaccid paralysis. Patients may present initially with nonspecific symptoms including fevers. Although rare, neuroinvasive WNV is associated with significant morbidity and mortality. Read More

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http://Insights.ovid.com/crossref?an=00004691-900000000-9948
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http://dx.doi.org/10.1097/WNP.0000000000000558DOI Listing
January 2019
6 Reads

Electroencephalographic Patterns During Common Nursing Interventions in Neurointensive Care: A Descriptive Pilot Study.

J Neurosci Nurs 2019 Feb;51(1):10-15

Kristin Elf, MD PhD, is Clinical Neurophysiologist and Researcher, Department of Neuroscience, Clinical Neurophysiology, Uppsala University, Uppsala, Sweden. Tommy Carlsson, PhD PGDip RN RM, is Postdoctoral Researcher, Department for Health Promoting Science, Sophiahemmet University, Stockholm; and Intensive Care Nurse and Researcher, Department of Neuroscience, Neurosurgery, Uppsala University; and Midwife and Researcher, Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. Liliana Santeliz Rivas, MSc RN, is Intensive Care Nurse, Department of Neuroscience, Neurosurgery, Uppsala University, Uppsala, Sweden. Emma Widnersson, MSc RN, is Intensive Care Nurse, Department of Neuroscience, Neurosurgery, Uppsala University, Uppsala, Sweden.

Background: Many patients with neurological insults requiring neurointensive care have an increased risk of acute symptomatic seizures. Various nursing interventions performed when caring for these patients may elicit pathological cerebral electrical activity including seizures and stimulus-induced rhythmic, periodic, or ictal discharges (SIRPIDs). The aim was to explore changes in electroencephalogram (EEG) due to neurointensive care nursing interventions. Read More

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http://dx.doi.org/10.1097/JNN.0000000000000411DOI Listing
February 2019

Epilepsy and interictal epileptiform activity in patients with autism spectrum disorders.

Epilepsy Behav 2019 Jan 2;92:45-52. Epub 2019 Jan 2.

Institute of Mental Health, Belgrade, Serbia; Faculty of Medicine, University of Belgrade, Belgrade, Serbia. Electronic address:

Purpose: The purpose of this study was to determine the prevalence of epilepsy and subclinical epileptiform abnormalities in children with autism spectrum disorder (ASD), and to investigate its effects on core autistic symptoms and adaptive behavior skills.

Methods: Patients with diagnosis of ASD who met full criteria on Autism Diagnostic Interview-Revised (ADI-R) were included in the study. Adaptive behavior skills were assessed by Vineland Adaptive Behavior Scale-II (VABS-II). Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.12.011DOI Listing
January 2019
2 Reads

Electromagnetic source imaging in presurgical workup of patients with epilepsy: A prospective study.

Neurology 2019 Feb 4;92(6):e576-e586. Epub 2019 Jan 4.

From the Departments of Clinical Neurophysiology (L.D., H.T., P.O.H., A.F.-F., S.B.) and Neurology (P.S.), Aarhus University Hospital; Departments of Neurology (A.S., L.H.P.), Clinical Neurophysiology (M.F., G. Rásonyi), Pediatrics, Child Neurology (P.U.), Neurosurgery (B.J., J.B.), and Clinical Physiology, Nuclear Medicine and PET (O.M.H.), Copenhagen University Hospital Rigshospitalet; Danish Epilepsy Centre (G. Rubboli, B.P., S.B.), Dianalund; and Department of Diagnostic Radiology (A.-M.L.), Hvidovre Hospital, Denmark.

Objective: To determine the diagnostic accuracy and clinical utility of electromagnetic source imaging (EMSI) in presurgical evaluation of patients with epilepsy.

Methods: We prospectively recorded magnetoencephalography (MEG) simultaneously with EEG and performed EMSI, comprising electric source imaging, magnetic source imaging, and analysis of combined MEG-EEG datasets, using 2 different software packages. As reference standard for irritative zone (IZ) and seizure onset zone (SOZ), we used intracranial recordings and for localization accuracy, outcome 1 year after operation. Read More

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http://dx.doi.org/10.1212/WNL.0000000000006877DOI Listing
February 2019
7 Reads

Reconstruction of post-synaptic potentials by reverse modeling of local field potentials.

J Neural Eng 2019 Jan 4;16(2):026023. Epub 2019 Jan 4.

Univ Rennes, INSERM, LTSI-U1099, F-35000 Rennes, France.

Objective: Among electrophysiological signals, local field potentials (LFPs) are extensively used to study brain activity, either in vivo or in vitro. LFPs are recorded with extracellular electrodes implanted in brain tissue. They reflect intermingled excitatory and inhibitory processes in neuronal assemblies. Read More

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http://dx.doi.org/10.1088/1741-2552/aafbfbDOI Listing
January 2019

After-Hours EEG: Relative Value of Emergent Routine Versus Prolonged EEG Recordings.

J Clin Neurophysiol 2019 Jan;36(1):32-35

University of Toledo, Toledo, Ohio, U.S.A.

Objective: After-hours EEG is increasingly used in hospital patients. Although the detection of seizures and interictal epileptiform discharges has been shown to be higher with prolonged EEG (pEEG) than routine-duration EEG, the relative value for particular indications can inform utilization.

Method: The Mayo EEG Report System was queried for after-hours emergent routine EEG (ErEEG) and pEEG performed between January 2015 and June 2015. Read More

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http://dx.doi.org/10.1097/WNP.0000000000000529DOI Listing
January 2019

Perisylvian epileptic network revisited.

Seizure 2019 Feb 21;65:31-41. Epub 2018 Dec 21.

National Institute of Clinical Neuroscience, Budapest, Hungary.

We overview here the new data about the epileptic spectrum disorders within the frame of perisylvian epileptic network since our first trial to synthetize knowledge about this system epilepsy (Halász et al., 2005). We found evidences for a continual features relating together syndromes constituting this spectrum disorder in several fields: in sharing genetic origin, in common perisylvian human communication circuitry, in NREM sleep related potentiation of interictal epileptiform discharges of the centro-temporal spike phenomenon and in the discharge related cognitive impairment, reflecting functional deficits in human communication abilities. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.12.003DOI Listing
February 2019
4 Reads

Mesial temporal extraventricular neurocytoma (mtEVN): A case report and literature review.

Epilepsy Behav Case Rep 2019 23;11:26-30. Epub 2018 Oct 23.

Division of Neurological Surgery, Department of Surgery, Lehigh Valley Health Network, 1250 S Cedar Crest Blvd, Suite 400, Allentown, PA 18103, United States of America.

Aim: We describe a case of mesial temporal extraventricular neurocytoma (mtEVN) in a 23-year-old male presenting with drug-resistant seizures and review the literature on this rare tumor.

Methods: A PubMed search was queried using the MeSH term "neurocytoma" and key search terms "extraventricular", "temporal", and "epilepsy". Titles and abstracts were screened for temporal neurocytomas. Read More

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http://dx.doi.org/10.1016/j.ebcr.2018.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310741PMC
October 2018
1 Read

Nodding syndrome- an Indian case.

Afr Health Sci 2018 Sep;18(3):837-841

Department of Pediatrics, Vardhman Mahavir Medical College and Safdarjang Hospital.

Background: Although nodding syndrome is a catastrophic epileptic encephalopathy, it is reported only from Africa so far. We describe the first case from the Indian sub-continent.

Methods: A ten-year-old child who had an episode of Guillain Barre syndrome with incomplete recovery developed emaciation secondary to bulbar palsy and depression. Read More

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https://www.ajol.info/index.php/ahs/article/view/176251
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http://dx.doi.org/10.4314/ahs.v18i3.43DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306992PMC
September 2018
3 Reads

Seizure associated with olanzapine.

J Family Med Prim Care 2018 Sep-Oct;7(5):1090-1092

Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India.

Atypical antipsychotics are known to be associated with electroencephalogram abnormalities. Olanzapine can lower seizure threshold and induce epileptiform discharges. However in patients on Olanzapine for the treatment of a primary psychiatric disorder, clinical seizure is a rare occurrence. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_405_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259505PMC
January 2019
1 Read

Spontaneous epileptiform activity in a rat model of bilateral subcortical band heterotopia.

Epilepsia 2019 Feb 30;60(2):337-348. Epub 2018 Dec 30.

Neurobiology Institute of the Mediterranean (INMED), Aix-Marseille University, French National Institute of Health and Medical Research (INSERM) UMR1249, Marseille, France.

Objective: Malformations of cortical development are common causes of intellectual disability and epilepsy, yet there is a crucial lack of relevant preclinical models associating seizures and cortical malformations. Here, we describe a novel rat model with bilateral subcortical band heterotopia (SBH) and examine whether this model develops spontaneous epileptic seizures.

Methods: To generate bilateral SBH in rats, we combined RNAi-mediated knockdown of Dcx and in utero electroporation with a tripolar electrode configuration enabling simultaneous transfection of the two brain hemispheres. Read More

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http://dx.doi.org/10.1111/epi.14633DOI Listing
February 2019
1 Read

Seizure in Alzheimer's Disease: An Underestimated Phenomenon.

Am J Alzheimers Dis Other Demen 2018 Dec 30:1533317518813551. Epub 2018 Dec 30.

3 Tehran University of Medical Sciences, Tehran, Iran.

Alzheimer's disease (AD) is considered as a potential risk factor for the development of seizure due to neurodegeneration and imbalance between stimulatory and inhibitory circuits in the brain. Seizure could occur in any point during the course of AD, and its presentation varies from fluctuation in cognitive domains to more typical seizures. The clinical diagnosis of seizure in patients with dementia may be challenging due to difficulty in history taking and clinical assessment. Read More

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http://dx.doi.org/10.1177/1533317518813551DOI Listing
December 2018
4 Reads

Focal epilepsy without interictal spikes on scalp EEG: A common finding of uncertain significance.

Epilepsy Res 2019 Feb 24;150:1-6. Epub 2018 Dec 24.

Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. Electronic address:

Objective: Interictal epileptiform discharges (IEDs) are important to identify the epileptogenic zone and to define epileptic syndromes. However, not all patients show IEDs on scalp EEG. We evaluate the likelihood of not findings spikes on prolonged Video-EEG Monitoring (VEM) in patients with focal epilepsy, and explore clinical correlates. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09201211183050
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http://dx.doi.org/10.1016/j.eplepsyres.2018.12.009DOI Listing
February 2019
41 Reads
2.015 Impact Factor

Sleep is associated with reduction of epileptiform discharges in benign adult familial myoclonus epilepsy.

Epilepsy Behav Case Rep 2019 16;11:18-21. Epub 2018 Oct 16.

Department of Epilepsy, Movement Disorders and Physiology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

To clarify the effects of sleep on cortical irritability in benign adult familial myoclonus epilepsy (BAFME), we retrospectively compared epileptiform discharges of electroencephalographies (EEGs) between awake and sleep periods in 5 patients (mean age: 49.6 ± 20.3 years). Read More

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http://dx.doi.org/10.1016/j.ebcr.2018.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305661PMC
October 2018
1 Read

Rare Phenomenon of Limb-shaking TIA, Resolved With Intracranial Wingspan Stenting.

Neurologist 2019 Jan;24(1):37-39

Departments of Neurology.

Objective: Illustrates the importance of differentiating limb-shaking transient ischemic attack (LS-TIA) from focal seizures and carefully selecting patients for intracranial stenting.

Background: LS-TIA is associated with severe carotid stenosis or occlusion, often precipitated by cerebral hypoperfusion. A case study of 313 patients with symptomatic intracranial artery stenosis/occlusion reported 11% with LS-TIA. Read More

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http://dx.doi.org/10.1097/NRL.0000000000000208DOI Listing
January 2019
2 Reads

Generalized Convulsive Status Epilepticus Secondary to Jarisch-Herxheimer Reaction in Neurosyphilis: A Case Report and Literature Review.

Neurologist 2019 Jan;24(1):29-32

Department of Neurology, Health Sciences Center, Federal University of Santa Maria, Rio Grande do Sul, Brazil.

Introduction: Jarisch-Herxheimer reaction (JHR) is defined as a transient immunologic reaction, classically seen in patients during syphilis treatment. JHR is a rare cause of status epilepticus (SE) in neurosyphilis. We describe a case of generalized convulsive SE (GCSE) probably secondary to JHR in a patient with neurosyphilis. Read More

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http://dx.doi.org/10.1097/NRL.0000000000000219DOI Listing
January 2019
2 Reads

Driving status of patients with generalized spike-wave on EEG but no clinical seizures.

Epilepsy Behav 2018 Dec 20;92:5-13. Epub 2018 Dec 20.

Department of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA; Department of Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA; Department of Neurosurgery, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA. Electronic address:

Generalized spike-wave discharges (SWDs) are the hallmark of generalized epilepsy on the electroencephalogram (EEG). In clinically obvious cases, generalized SWDs produce myoclonic, atonic/tonic, or absence seizures with brief episodes of staring and behavioral unresponsiveness. However, some generalized SWDs have no obvious behavioral effects. Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.11.031DOI Listing
December 2018
5 Reads

Glycolytic inhibition: A novel approach toward controlling neuronal excitability and seizures.

Epilepsia Open 2018 Dec 19;3(Suppl Suppl 2):191-197. Epub 2018 Aug 19.

Division of Pediatric Neurology Department of Neurology Johns Hopkins University School of Medicine Baltimore Maryland U.S.A.

Conventional antiseizure medications reduce neuronal excitability through effects on ion channels or synaptic function. In recent years, it has become clear that metabolic factors also play a crucial role in the modulation of neuronal excitability. Indeed, metabolic regulation of neuronal excitability is pivotal in seizure pathogenesis and control. Read More

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http://dx.doi.org/10.1002/epi4.12251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293058PMC
December 2018
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Cellular antiseizure mechanisms of everolimus in pediatric tuberous sclerosis complex, cortical dysplasia, and non-mTOR-mediated etiologies.

Epilepsia Open 2018 Dec 2;3(Suppl Suppl 2):180-190. Epub 2018 Sep 2.

Division of Pediatric Neurology Mattel Children's Hospital David Geffen School of Medicine at University of California Los Angeles Los Angeles California U.S.A.

The present study was designed to examine the potential cellular antiseizure mechanisms of everolimus, a mechanistic target of rapamycin (mTOR) pathway blocker, in pediatric epilepsy cases. Cortical tissue samples obtained from pediatric patients (n = 11, ages 0.67-6. Read More

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http://dx.doi.org/10.1002/epi4.12253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293070PMC
December 2018

Interrater reliability in visual identification of interictal high-frequency oscillations on electrocorticography and scalp EEG.

Epilepsia Open 2018 Dec 2;3(Suppl Suppl 2):127-132. Epub 2018 Nov 2.

Division of Pediatric Neurology UCLA Mattel Children's Hospital David Geffen School of Medicine Los Angeles California U.S.A.

High-frequency oscillations (HFOs), including ripples (Rs) and fast ripples (FRs), are promising biomarkers of epileptogenesis, but their clinical utility is limited by the lack of a standardized approach to identification. We set out to determine whether electroencephalographers experienced in HFO analysis can reliably identify and quantify interictal HFOs. Two blinded raters independently reviewed 10 intraoperative electrocorticography (ECoG) samples from epilepsy surgery cases, and 10 scalp EEG samples from epilepsy monitoring unit evaluations. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/epi4.12266
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http://dx.doi.org/10.1002/epi4.12266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293061PMC
December 2018
6 Reads

Late-onset Lennox-Gastaut syndrome: Diagnostic evaluation and outcome.

Neurol Clin Pract 2018 Oct;8(5):397-402

Department of Neurology, Mayo Clinic, Rochester, MN.

Background: We describe the clinical features and outcome in patients with late-onset Lennox-Gastaut syndrome (LGS).

Methods: Adult patients evaluated between January 1, 2000, and March 1, 2017, who presented with onset of LGS ≥10 years were identified. Data abstracted included age at seizure onset, seizure types, etiology, treatments, EEG and neuroimaging results, cerebrospinal fluid (CSF) findings, and autoimmune evaluation. Read More

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http://dx.doi.org/10.1212/CPJ.0000000000000527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276343PMC
October 2018
1 Read

Identification of Hidden Sources by Estimating Instantaneous Causality in High-Dimensional Biomedical Time Series.

Int J Neural Syst 2018 Oct 29:1850051. Epub 2018 Oct 29.

1 Department of Electrical and Computer Engineering, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece.

The study of connectivity patterns of a system's variables, such as multi-channel electroencephalograms (EEG), is of utmost importance towards a better understanding of its internal evolutionary mechanisms. Here, the problem of estimating the connectivity network from multivariate time series in the presence of prominent unobserved variables is addressed. The causality measure of partial mutual information from mixed embedding (PMIME), designed to estimate direct lag-causal effects in the presence of many observed variables, is adapted to estimate also zero-lag effects, the so-called instantaneous causality. Read More

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http://dx.doi.org/10.1142/S012906571850051XDOI Listing
October 2018

Frequency and Stratification of Epileptogenic Lesions in Elderly With New Onset Seizures.

Front Neurol 2018 30;9:995. Epub 2018 Nov 30.

American University of Beirut Medical Center, Beirut, Lebanon.

To evaluate prospectively the frequency of epileptogenic lesions in a consecutive cohort of elderly patients presenting with new onset unprovoked seizures, and who underwent a complete evaluation including dedicated epilepsy protocol MRI. We included all consecutive patients 60 years or older who participated in a prospective study on new onset epilepsy. The work-up included the acquisition of a dedicated epilepsy protocol MRI and a 3 h video/EEG recording. Read More

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http://dx.doi.org/10.3389/fneur.2018.00995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284348PMC
November 2018
1 Read

Acute non-convulsive status epilepticus after experimental traumatic brain injury in rats.

J Neurotrauma 2018 Dec 13. Epub 2018 Dec 13.

University of Eastern Finalnd , Neulaniementie 2 , Kuopio, Finland , 70211 ;

Severe traumatic brain injury (TBI) induces seizures or status epilepticus (SE) in 20%-30% of patients during the acute phase. We hypothesized that severe TBI induced with lateral fluid-percussion injury (FPI) triggers post-impact SE. Adult Sprague-Dawley male rats were anesthetized with isoflurane and randomized into sham-operated experimental control or lateral FPI-induced severe TBI groups. Read More

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https://www.liebertpub.com/doi/10.1089/neu.2018.6107
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http://dx.doi.org/10.1089/neu.2018.6107DOI Listing
December 2018
2 Reads

Running-down phenomenon captured with chronic electrocorticography.

Epilepsia Open 2018 Dec 19;3(4):528-534. Epub 2018 Oct 19.

Department of Neurology NYU School of Medicine New York New York U.S.A.

The running-down phenomenon refers to 2 analogous but distinct entities that may be seen after epilepsy surgery. The first is clinical, and denotes a progressive diminution in seizures after epilepsy surgery in which the epileptogenic zone could not be completely removed (Modern Problems of Psychopharmacology 1970;4:306, Brain 1996:989). The second is electrographic, and refers to a progressive deactivation of a secondary seizure focus after removal of the primary epileptogenic zone. Read More

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http://dx.doi.org/10.1002/epi4.12265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276771PMC
December 2018
2 Reads

How do we use in vitro models to understand epileptiform and ictal activity? A report of the TASK1-WG4 group of the ILAE/AES Joint Translational Task Force.

Epilepsia Open 2018 Dec 2;3(4):460-473. Epub 2018 Nov 2.

Epilepsy Unit Fondazione IRCCS Istituto Neurologico Carlo Besta Milano Italy.

In vitro brain tissue preparations allow the convenient and affordable study of brain networks and have allowed us to garner molecular, cellular, and electrophysiologic insights into brain function with a detail not achievable in vivo. Preparations from both rodent and human postsurgical tissue have been utilized to generate in vitro electrical activity similar to electrographic activity seen in patients with epilepsy. A great deal of knowledge about how brain networks generate various forms of epileptiform activity has been gained, but due to the multiple in vitro models and manipulations used, there is a need for a standardization across studies. Read More

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http://doi.wiley.com/10.1002/epi4.12277
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http://dx.doi.org/10.1002/epi4.12277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276782PMC
December 2018
7 Reads

Erratum: Two-Year Follow-up of Isolated Epileptiform Discharges in Autism: An Endophenotypic Biomarker?

Authors:

Indian J Psychol Med 2018 Nov-Dec;40(6):602

[This corrects the article on p. 219 in vol. 40, PMID: 29875528. Read More

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http://dx.doi.org/10.4103/0253-7176.245092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241183PMC
December 2018