3,956 results match your criteria Epileptiform Discharges


Electro-clinical analysis of epilepsy patients with generalized seizures on adjunctive perampanel treatment.

Epilepsy Res 2020 May 31;165:106378. Epub 2020 May 31.

Epilepsy Unit, Department of Clinical Neurophysiology, Lluis Alcanyis Hospital, Carretera Xátiva-Silla, Km 2, 46800, Xàtiva, Valencia, Spain.

Quantifying epileptiform discharges before and after the initiation of treatment can be useful for evaluating the efficacy of antiepileptic drugs in generalized epilepsy. The aim of this study was to determine if the selective α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor antagonist perampanel alters the electroencephalographic signals in patients with drug resistant generalized seizures (primary or secondary). We also assessed the clinical efficacy, safety and tolerability of perampanel as an adjunctive treatment for patients with refractory generalized seizures after 3, 6 and 12 months of treatment to determine if there is an electro-clinical correlation. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2020.106378DOI Listing

Removal of a temporal lobe cavernous angioma to control epileptic seizures in a patient with tuberous sclerosis complex.

Heliyon 2020 Jun 23;6(6):e04229. Epub 2020 Jun 23.

Comprehensive Epilepsy Center, Seirei Hamamatsu General Hospital, Japan.

Purpose: A patient with tuberous sclerosis complex (TSC) and a left temporal cavernous angioma (CA) presented with treatment-resistant epilepsy. We evaluated the patient to determine the best treatment option.

Patient And Methods: A 7-year-old boy with TSC exhibited weekly impaired awareness seizures and was diagnosed with TSC based on the modified Gomez's criteria. Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e04229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322044PMC

Long-term effects of vagus nerve stimulation in refractory pediatric epilepsy: A single-center experience.

Epilepsy Behav 2020 Jun 27;110:107147. Epub 2020 Jun 27.

Hacettepe University Faculty of Medicine, Department of Pediatric Neurology; currently retired from Hacettepe University, Department of Pediatric Neurology.

Introduction: Vagus nerve stimulation (VNS) has been used as an adjunctive therapy for both children and adults with refractory epilepsy, over the last two decades. In this study, we aimed to evaluate the long-term effects and tolerability of VNS in the pediatric drug-resistant epilepsy (DRE) and to identify the predictive factors for responsiveness to VNS.

Methods: We retrospectively reviewed the medical records of pediatric patients who underwent VNS implantation between 1997 and 2018. Read More

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http://dx.doi.org/10.1016/j.yebeh.2020.107147DOI Listing

Clinical and electroencephalographic features of benign childhood epilepsy with centrotemporal spikes comorbidity with attention-deficit hyperactivity disorder in Southwest China.

Epilepsy Behav 2020 Jun 27;111:107240. Epub 2020 Jun 27.

Department of Neurology, West China Hospital, Sichuan University, Wai Nan Guo Xue Lane 37#, Chengdu, Sichuan 610041, China. Electronic address:

Purpose: This study was conducted to analyze the clinical and electroencephalographic (EEG) features of attention-deficit hyperactivity disorder (ADHD) in children with benign partial epilepsy with centrotemporal spikes (BECTS) in Southwest China, to address the question of what the risk factors are for patients with BECTS who suffer from ADHD.

Methods: Overall 118 right-handed children with BECTS were included from two medical centers. Of them, 29 patients were with diagnosed ADHD according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V) at baseline, and the remaining were considered as typical BECTS. Read More

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http://dx.doi.org/10.1016/j.yebeh.2020.107240DOI Listing

Inter-ictal EEG patterns in malformations of cortical development and epilepsy.

Clin Neurol Neurosurg 2020 Jun 15;196:106022. Epub 2020 Jun 15.

Department of Radiology, Krishna Institute of Medical Sciences, Secunderabad, India.

Objectives: Malformations of cortical Development (MCDs) are associated with refractory epilepsy. We evaluated scalp inter-ictal EEG patterns in various types of MCD, and its association with clinical features and seizure control.

Patients And Methods: Retrospective analysis of demographic, clinical, inter-ictal EEG and seizure outcome data of 665 patients with epilepsy and MCD with at least two years follow up was performed. Read More

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http://dx.doi.org/10.1016/j.clineuro.2020.106022DOI Listing

EEG autoregressive modeling analysis: A diagnostic tool for patients with epilepsy without epileptiform discharges.

Clin Neurophysiol 2020 Jun 8;131(8):1902-1908. Epub 2020 Jun 8.

Department of Pediatrics, School of Medicine, College of Medicine, Kaohsiung Medical University, Taiwan, ROC; Departments of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Taiwan, ROC. Electronic address:

Objective: Numerous types of nonepileptic paroxysmal events, such as syncopes and psychogenic nonepileptic seizures, may imitate epileptic seizures and lead to diagnostic difficulty. Such misdiagnoses may lead to inappropriate treatment in patients that can considerably affect their lives. Electroencephalogram (EEG) is a commonly used tool in assisting diagnosis of epilepsy. Read More

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http://dx.doi.org/10.1016/j.clinph.2020.04.172DOI Listing

Seizures in meningioma.

Handb Clin Neurol 2020 ;170:187-200

Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, United States. Electronic address:

More than one-third of patients with meningiomas will experience seizures at some point in their disease. Despite this, meningioma-associated epilepsy remains significantly understudied, as most investigations focus on tumor progression, extent of resection, and survival. Due to the impact of epilepsy on the patient's quality of life, identifying predictors of preoperative seizures and postoperative seizure freedom is critical. Read More

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http://dx.doi.org/10.1016/B978-0-12-822198-3.00053-7DOI Listing
January 2020

Effects of Independent Component Analysis on Magnetoencephalography Source Localization in Pre-surgical Frontal Lobe Epilepsy Patients.

Front Neurol 2020 2;11:479. Epub 2020 Jun 2.

Neurology and Neurosurgery Department, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.

Magnetoencephalography source imaging (MSI) of interictal epileptiform discharges (IED) is a useful presurgical tool in the evaluation of drug-resistant frontal lobe epilepsy (FLE) patients. Yet, failures in MSI can arise related to artifacts and to interference of background activity. Independent component analysis (ICA) is a popular denoising procedure but its clinical application remains challenging, as the selection of multiple independent components (IC) is controversial, operator dependent, and time consuming. Read More

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http://dx.doi.org/10.3389/fneur.2020.00479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280485PMC

Expert opinion: Proposed diagnostic and treatment algorithms for Lennox-Gastaut syndrome in adult patients.

Epilepsy Behav 2020 Jun 18;110:107146. Epub 2020 Jun 18.

Banner University Medical Center, University of Arizona, 1111 E McDowell Rd, Phoenix, AZ 85006, USA. Electronic address:

Lennox-Gastaut syndrome (LGS) is a severe developmental epileptic encephalopathy diagnosed in childhood that persists through adolescence and into adulthood. While the characteristics of LGS in pediatric patients are well defined, including "drop attacks", interictal slow spike and wave electroencephalogram (EEG) activity, and intellectual disability, these features can evolve over time, and different EEG activities may be present in adult patients with LGS. This may result in missed diagnoses in these patients and subsequent challenges for the adequate treatment of their seizures. Read More

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http://dx.doi.org/10.1016/j.yebeh.2020.107146DOI Listing

Epileptic seizure prediction based on EEG spikes detection of ictal-preictal states.

J Biomed Res 2020 Feb;34(3):162-169

Centre de Recherche et de Production Research Lab., Ecole Nationale Supérieure des Ingénieurs de Tunis, University of Tunis, Tunis 1008, Tunisia.

Epileptic seizures are known for their unpredictable nature. However, recent research provides that the transition to seizure event is not random but the result of evidence accumulations. Therefore, a reliable method capable to detect these indications can predict seizures and improve the life quality of epileptic patients. Read More

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http://dx.doi.org/10.7555/JBR.34.20190097DOI Listing
February 2020

Characterizing Sunflower syndrome: a clinical series.

Epileptic Disord 2020 Jun;22(3):273-280

Pediatric Epilepsy Program, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.

To characterize the clinical phenotype of Sunflower syndrome. Sunflower syndrome is a rare photosensitive epilepsy syndrome characterized by highly stereotyped seizures, photosensitivity, and heliotropism. We retrospectively reviewed the medical records of patients seen in the Massachusetts General Hospital for Children (MGHfC) pediatric epilepsy program with a history of Sunflower syndrome. Read More

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http://dx.doi.org/10.1684/epd.2020.1161DOI Listing

Sensitivity of magnetoencephalography as a diagnostic tool for epilepsy: a prospective study.

Epileptic Disord 2020 Jun;22(3):264-272

Department of Clinical Neurophysiology, Academic Centre for Epileptology, Kempenhaeghe / MUMC+, Heeze.

The diagnostic process for epilepsy can be lengthy and stressful, which may delay the start of treatment. The objective of this study was to determine the benefit of routine magnetoencephalography (MEG) with regard to diagnostic gain, compared to routine electroencephalography (EEG), EEG following sleep deprivation (EEGsd), and 24-hour EEG. In this prospective study, patients were included from two centres (Academic Centre for Epileptology Kempenhaeghe, Heeze and Elisabeth-Twee Steden Hospital, Tilburg) and MEG recording took place at a single centre (Amsterdam University Medical Centre, Vrije Universiteit Amsterdam) in The Netherlands. Read More

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http://dx.doi.org/10.1684/epd.2020.1160DOI Listing

Spike-associated networks and intracranial electrographic findings.

Epileptic Disord 2020 Jun;22(3):291-299

Department of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora,, Research Service, Rocky Mountain Regional VA Medical Center, Aurora, USA.

Functional connectivity is providing new insights into the network nature of epilepsy with growing clinical applications. Our objective was to validate a novel magnetoencephalography-based method to non-invasively measure the epileptic network. We retrospectively identified pediatric and adult patients with refractory focal epilepsy who underwent pre-surgical magnetoencephalography with subsequent intracranial electrographic monitoring. Read More

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http://dx.doi.org/10.1684/epd.2020.1163DOI Listing

Variations in Values of State, Response Entropy and Haemodynamic Parameters Associated with Development of Different Epileptiform Patterns during Volatile Induction of General Anaesthesia with Two Different Anaesthetic Regimens Using Sevoflurane in Comparison with Intravenous Induct: A Comparative Study.

Brain Sci 2020 Jun 12;10(6). Epub 2020 Jun 12.

Department of Anaesthesiology and Intensive Therapy, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland.

Background And Objectives: Raw electroencephalographic (EEG) signals are rarely used to monitor the depth of volatile induction of general anaesthesia (VIGA) with sevoflurane, even though EEG-based indices may show aberrant values. We aimed to identify whether response (RE) and state entropy (SE) variations reliably reflect the actual depth of general anaesthesia in the presence of different types of epileptiform patterns (EPs) in EEGs during induction of general anaesthesia.

Materials And Methods: A randomized, prospective clinical study was performed with 60 patients receiving VIGA using sevoflurane with the increasing concentrations (group VIMA) or the vital capacity (group VCRII) technique or an intravenous single dose of propofol (group PROP). Read More

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http://dx.doi.org/10.3390/brainsci10060366DOI Listing

EEG findings in acutely ill patients investigated for SARS-CoV-2/COVID-19: A small case series preliminary report.

Epilepsia Open 2020 Jun 17;5(2):314-324. Epub 2020 May 17.

Saul R. Korey Department of Neurology Albert Einstein College of Medicine Bronx NY USA.

Objective: Acute encephalopathy may occur in COVID-19-infected patients. We investigated whether medically indicated EEGs performed in acutely ill patients under investigation (PUIs) for COVID-19 report epileptiform abnormalities and whether these are more prevalent in COVID-19 positive than negative patients.

Methods: In this retrospective case series, adult COVID-19 inpatient PUIs underwent EEGs for acute encephalopathy and/or seizure-like events. Read More

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http://dx.doi.org/10.1002/epi4.12399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289172PMC

Effect of Mozart K.448 on interictal epileptiform discharges in children with epilepsy: A randomized controlled pilot study.

Epilepsy Behav 2020 Jun 11:107177. Epub 2020 Jun 11.

Division of Pediatric Neurology, Department of Pediatrics, King Chulalongkorn Memorial Hospital/Thai Red Cross Society, Thailand; Division of Pediatric Neurology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Thailand.

Background: Epilepsy is a common pediatric neurologic disease in Thailand. However, the mainstay antiepileptic pharmacotherapies can induce severe side effects. While the benefit of playing Mozart K. Read More

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http://dx.doi.org/10.1016/j.yebeh.2020.107177DOI Listing

The effect of interictal epileptiform discharges on cognitive and academic performance in children with idiopathic epilepsy.

BMC Neurol 2020 Jun 6;20(1):233. Epub 2020 Jun 6.

Department of Pediatric Neurology, Capital Institute of Pediatrics, Beijing, 100020, China.

Background: Interictal epileptiform discharges (IEDs) have been proven to impair cognitive function. However, it is not clear whether IEDs disrupt academic performance in children with idiopathic epilepsy, and the contribution of cognitive function deficits to impaired academic performance has not been clarified. This study aimed to examine the cognitive deficits and academic impairment in childhood idiopathic epilepsy with IEDs. Read More

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http://dx.doi.org/10.1186/s12883-020-01807-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275426PMC

Electrical cortical stimulations modulate spike and post-spike slow-related high-frequency activities in human epileptic foci.

Clin Neurophysiol 2020 May 11;131(8):1741-1754. Epub 2020 May 11.

Department of Epilepsy, Movement Disorders and Physiology, Kyoto University Graduate School of Medicine, Kyoto, Japan. Electronic address:

Objective: Using interictal epileptiform discharges (IEDs), consisting of spikes and post-spike slow waves (PSSs), and IED-related high-frequency activities (HFAs), we elucidated inhibitory effects of electrical cortical stimulation (ECS) on human epileptic foci.

Methods: We recruited 8 patients with intractable focal epilepsy, and 50-Hz ECS was applied to the seizure-onset zone (SOZ) and non-SOZ. Before (5-min) and after (20-min) ECS, we evaluated the number of IED, the amplitudes of spikes and PSSs, spike-related HFA power, and PSS-related low gamma (30-50 Hz) activities. Read More

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http://dx.doi.org/10.1016/j.clinph.2020.03.042DOI Listing

Detection of interictal epileptiform discharges: A comparison of on-scalp MEG and conventional MEG measurements.

Clin Neurophysiol 2020 May 11;131(8):1711-1720. Epub 2020 May 11.

NatMEG, Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.

Objective: Conventional MEG provides an unsurpassed ability to, non-invasively, detect epileptic activity. However, highly resolved information on small neuronal populations required in epilepsy diagnostics is lost and can be detected only intracranially. Next-generation on-scalp magnetencephalography (MEG) sensors aim to retrieve information unavailable to conventional non-invasive brain imaging techniques. Read More

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http://dx.doi.org/10.1016/j.clinph.2020.03.041DOI Listing

Hypnagogic Frontal EEG Bursts in Children: Epileptic or Not?

Authors:
Anita N Datta

J Clin Neurophysiol 2020 May 28. Epub 2020 May 28.

Division of Neurology, Department of Pediatrics, BC Children's Hospital, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.

Purpose: Various EEG patterns emerge in drowsiness. Intermittent bilateral midfrontal slowing (BFS) and hypnogogic frontal predominant sharply contoured waveforms (HFSC), maximal at (Fz, F3-4, and Fp1-2), are often encountered. These do not meet the criteria for epileptiform discharges. Read More

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http://dx.doi.org/10.1097/WNP.0000000000000722DOI Listing

Evaluation of a new wireless technique for continuous electroencephalography monitoring in neurological intensive care patients.

J Clin Monit Comput 2020 Jun 2. Epub 2020 Jun 2.

Department of Anesthesiology, Johannes Gutenberg Universitaet, Universitaetsmedizin Mainz, Langenbeckstrasse 1, 55131, Mainz, Germany.

A novel wireless eight-channel electroencephalography (EEG) headset specially developed for ICUs was tested in regard of comparability with standard 10/20 EEG systems. The continuous EEG (cEEG) derivations via CerebAir EEG headset (Nihon Kohden Europe, Rosbach, Germany) and internationally standardized 10/20 reference EEGs as the diagnostic standard were performed in a mixed collective on a neurointensive care unit (neuro-ICU). The derivations were verified for comparability in detection of EEG background activity, epileptiform discharges, and seizure patterns. Read More

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http://dx.doi.org/10.1007/s10877-020-00533-8DOI Listing

Partial Activation of TrkB Receptors Corrects Interneuronal Calcium Channel Dysfunction and Reduces Epileptogenic Activity in Neocortex following Injury.

Cereb Cortex 2020 Jun 3. Epub 2020 Jun 3.

Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305-5122, USA.

Decreased GABAergic inhibition due to dysfunction of inhibitory interneurons plays an important role in post-traumatic epileptogenesis. Reduced N-current Ca2+ channel function in GABAergic terminals contributes to interneuronal abnormalities and neural circuit hyperexcitability in the partial neocortical isolation (undercut, UC) model of post-traumatic epileptogenesis. Because brain-derived neurotrophic factor (BDNF) supports the development and maintenance of interneurons, we hypothesized that the activation of BDNF tropomyosin kinase B (TrkB) receptors by a small molecule, TrkB partial agonist, PTX BD4-3 (BD), would correct N channel abnormalities and enhance inhibitory synaptic transmission in UC cortex. Read More

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http://dx.doi.org/10.1093/cercor/bhz254DOI Listing

A three-dimensional micro-electrode array for in-vitro neuronal interfacing.

J Neural Eng 2020 Jul 3;17(3):036033. Epub 2020 Jul 3.

Department of Electrical and Electronic Engineering (DIEE), University of Cagliari, Via Marengo 3, 09123, Cagliari, Italy. Author to whom any correspondence should be addressed.

Objective: In this paper, we report on the development of an easy-to-fabricate three-dimensional Micro-Electrode Array (3D-MEA) specifically designed for brain-on-a-dish applications.

Approach: The proposed device consists of pillar-shaped gold microelectrodes realized by electroplating directly on top of a standard MEA, making this approach highly versatile and convenient for batch fabrication. Moreover, with this simple technique, it is possible to obtain electrodes with a height of more than 100 µm onto different kind of substrates, ranging from glass to flexible plastic ones. Read More

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http://dx.doi.org/10.1088/1741-2552/ab9844DOI Listing

EEG-based classification of epilepsy and PNES: EEG microstate and functional brain network features.

Brain Inform 2020 May 29;7(1). Epub 2020 May 29.

Department of Mathematics and Computer Science, Eindhoven University of Technology, TU/e, P.O.Box: 513, 5600MB, Eindhoven, NL, The Netherlands.

Epilepsy and psychogenic non-epileptic seizures (PNES) often show over-lap in symptoms, especially at an early disease stage. During a PNES, the electrical activity of the brain remains normal but in case of an epileptic seizure the brain will show epileptiform discharges on the electroencephalogram (EEG). In many cases an accurate diagnosis can only be achieved after a long-term video monitoring combined with EEG recording which is quite expensive and time-consuming. Read More

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http://dx.doi.org/10.1186/s40708-020-00107-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260313PMC

Differential early effects of traumatic brain injury on spike-wave discharges in Sprague-Dawley rats.

Neurosci Res 2020 May 24. Epub 2020 May 24.

Laboratory of Functional Biochemistry of the Nervous System, Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, 5A Butlerov Str., 117485 Moscow, Russia; Moscow Research and Clinical Center for Neuropsychiatry of the Healthcare Department of Moscow, 43 Donskaya Str., 115419 Moscow, Russia. Electronic address:

Unprovoked seizures in the late period of traumatic brain injury (TBI) occur in almost 20% of humans and experimental animals, psychiatric comorbidities being common in both situations. The aim of the study was to evaluate epileptiform activity in the early period of TBI induced by lateral fluid percussion brain injury in adult male Srague-Dawley rats and to reveal potential behavioral and pathomorphological correlates of early electrophysiological alterations. One week after TBI the group of animals was remarkably heterogeneous regarding the incidence of bifrontal 7-Hz spikes and spike-wave discharges (SWDs). Read More

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http://dx.doi.org/10.1016/j.neures.2020.05.005DOI Listing

Epilepsy and Its Interaction With Sleep and Circadian Rhythm.

Front Neurol 2020 8;11:327. Epub 2020 May 8.

Department of Neurology, Epilepsy Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Growing evidence shows the bidirectional interactions between sleep, circadian rhythm, and epilepsy. Comprehending how these interact with each other may help to advance our understanding of the pathophysiology of epilepsy and develop new treatment strategies to improve seizure control by reducing the medication side effects and the risks associated with seizures. In this review, we present the overview of different temporal patterns of interictal epileptiform discharges and epileptic seizures over a period of 24 consecutive hours. Read More

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http://dx.doi.org/10.3389/fneur.2020.00327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225332PMC

Spreading Depolarization Facilitates the Transition of Neuronal Burst Firing from Interictal to Ictal State.

Neuroscience 2020 May 23. Epub 2020 May 23.

Epilepsy Research Center, Westfälische Wilhelms-Universität Münster, Germany; Department of Neurosurgery, Westfälische Wilhelms-Universität Münster, Germany; Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran; Department of Neurology and Institute of Translational Neurology, Westfälische Wilhelms-Universität Münster, Germany; Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

The transition of neuronal burst firing from the interictal to ictal state contributes to seizure initiation in human temporal lobe epilepsy. The low-Mg model of seizure is characterized by initial spontaneous interictal bursting events, which later developed into ictaform discharges. Both experimental and clinical studies point to a complex link between spreading depolarization (SD) and epileptiform field potentials (EFP), including SD-induced epileptic seizures. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2020.05.029DOI Listing

Safe and sound: Meta-analyzing the Mozart effect on epilepsy.

Clin Neurophysiol 2020 Jul 30;131(7):1610-1620. Epub 2020 Apr 30.

EPILAB - Epilepsy and Clinical Neurophysiology Laboratory, Department of Developmental Neuroscience, IRCCS Stella Maris Foundation, Pisa, Italy. Electronic address:

Objective: The use of music-based neuro-stimulation for treating seizures and interictal epileptiform discharges (IED) (the so-called "Mozart effect") remains a controversial issue. We have conducted an updated meta-analysis in order to systematically review literature evidence and provide further insights about the role of the Mozart effect in epilepsy.

Methods: Following the "Preferred Reporting Items for Systematic Reviews and Meta-Analyses" (PRISMA) guidelines, we searched three bibliographic databases from their date of inception to January 2020. Read More

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http://dx.doi.org/10.1016/j.clinph.2020.03.039DOI Listing

Predictors of drug-resistance in epilepsy with auditory features.

Epilepsy Res 2020 Aug 11;164:106353. Epub 2020 May 11.

Department of Neurology, West China Hospital, Sichuan University, No. 37 Guoxue Road, Chengdu 610041, Sichuan Province, China. Electronic address:

Objective: To investigate predictors of drug-resistance in epilepsy with auditory features (EAF).

Methods: Drug-resistant epilepsy (DRE) was defined according to International League Against Epilepsy guidelines. For univariate analysis, the chi-squared, Fisher's exact, and Mann-Whitney test were used. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2020.106353DOI Listing

Epilepsy and Electroencephalographic Abnormalities in SATB2-Associated Syndrome.

Pediatr Neurol 2020 Apr 13. Epub 2020 Apr 13.

Section of Genetics and Metabolism, Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas. Electronic address:

Background: Seizures are an under-reported feature of the SATB2-associated syndrome phenotype. We describe the electroencephalographic findings and seizure semiology and treatment in a population of individuals with SATB2-associated syndrome.

Methods: We performed a retrospective review of 101 individuals with SATB2-associated syndrome who were reported to have had a previous electroencephalographic study to identify those who had at least one reported abnormal result. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2020.04.006DOI Listing

Prolonged prophylactic effects of gabapentin on status epilepticus-induced neocortical injury.

Neurobiol Dis 2020 May 19;142:104949. Epub 2020 May 19.

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

Long-term consequences of status epilepticus (SE) occur in a significant proportion of those who survive the acute episode. We developed an in vivo model of acute focal neocortical SE (FSE) to study long-term effects on local cortical structure and function and potential strategies to mitigate adverse consequences of SE. An acute 2 h episode of FSE was induced in anesthetized mice by epidural application of gabazine +4-aminopyridine over sensorimotor neocortex. Read More

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http://dx.doi.org/10.1016/j.nbd.2020.104949DOI Listing

Does Early Recognition of Treatment Failure and Changing Anti-Epilepsy Medication Regimen Improve Short-Term Seizure Remission Rates In Childhood Absence Epilepsy?

Acta Neurol Taiwan 2020 Jun;29(2):46-53

Comprehensive Epilepsy Program, Department of Neurology, Southern California Permanente Medical Center, Anaheim, California, USA.

Purpose: To study the role of early serial EEGs in improving seizure freedom rates after initiation of ethosuximide or valproic acid for childhood absence epilepsy.

Methods: Retrospective data analysis study of AED naive patients with childhood absence epilepsy undergoing treatment at the community-based epilepsy clinic. Due to small sample size Fisher's exact test was used to determine two-tailed p value at less than 0. Read More

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Electroclinical Findings of Epileptic Encephalopathy.

J Pediatr Neurosci 2020 Jan-Mar;15(1):29-33. Epub 2020 Mar 18.

Child Neurology Section, Department of Pediatrics, University of Arkansas for Medical Sciences (UAMS), Little Rock, AR, USA.

Introduction: Early-onset epileptic encephalopathies are among the most severe early-onset epilepsies, leading to progressive neurodegeneration. An increasing number of novel genetic causes continue to be uncovered as the primary etiology.

Results: We report a girl infant of Semitic (Saudi Arabian) descent who presented with multifocal seizures and later developed intractable infantile spasms and myoclonic seizures. Read More

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http://dx.doi.org/10.4103/JPN.JPN_10_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227754PMC

Abolishing spontaneous epileptiform activity in human brain tissue through AMPA receptor inhibition.

Ann Clin Transl Neurol 2020 Jun 19;7(6):883-890. Epub 2020 May 19.

Aston Neuroscience Institute, School of Life and Health Sciences, Aston University, Birmingham, UK.

Objective: The amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) is increasingly recognized as a therapeutic target in drug-refractory pediatric epilepsy. Perampanel (PER) is a non-competitive AMPAR antagonist, and pre-clinical studies have shown the AMPAR-mediated anticonvulsant effects of decanoic acid (DEC), a major medium-chain fatty acid provided in the medium-chain triglyceride ketogenic diet.

Methods: Using brain tissue resected from children with intractable epilepsy, we recorded the effects of PER and DEC in vitro. Read More

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http://dx.doi.org/10.1002/acn3.51030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318092PMC

Congruence and Discrepancy of Interictal and Ictal EEG With MRI Lesions in Pediatric Epilepsies.

Clin EEG Neurosci 2020 May 18:1550059420921712. Epub 2020 May 18.

Ludwig Maximilians University (LMU) Munich, Epilepsy Center, Munich, Germany.

. To evaluate the congruence or discrepancy of the localization of magnetic resonance imaging (MRI) lesions with interictal epileptiform discharges (IEDs) or epileptic seizure patterns (ESPs) in surface EEG in lesional pediatric epilepsy patients. . Read More

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http://dx.doi.org/10.1177/1550059420921712DOI Listing

EEG in fitness to drive evaluations in people with epilepsy - Considerable variations across Europe.

Seizure 2020 Jul 30;79:56-60. Epub 2020 Apr 30.

Division of Clinical Neuroscience, National Centre for Epilepsy, Oslo University Hospital, Norway.

Purpose: Epilepsy patients consider driving issues to be one of their most serious concerns. Ideally, decisions regarding fitness to drive should be based upon thorough evaluations by specialists in epilepsy care. In 2009, an EU directive was published aiming to harmonize evaluation practices within European countries, but, despite these recommendations, whether all epileptologists use the same criteria is unclear. Read More

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http://dx.doi.org/10.1016/j.seizure.2020.04.013DOI Listing

Neuronal injury and death following focal mild brain injury: The role of network excitability and seizure.

Iran J Basic Med Sci 2020 Jan;23(1):63-70

Faculty of Pharmacy, Department of Toxicology, Tehran University of Medical Sciences, Tehran, Iran.

Objectives: While traumatic brain injury (TBI) is a predisposing factor for development of post-traumatic epilepsy (PTE), the occurrence of seizures following brain trauma can infuriate adverse consequences of brain injury. However, the effect of seizures in epileptogenesis after mild TBI cannot yet be accurately confirmed. This study was designed to investigate the histopathological and molecular modifications induced by seizures on traumatized brain. Read More

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http://dx.doi.org/10.22038/IJBMS.2019.37558.8932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206845PMC
January 2020

Accuracy and spatial properties of distributed magnetic source imaging techniques in the investigation of focal epilepsy patients.

Hum Brain Mapp 2020 May 9. Epub 2020 May 9.

Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.

Source localization of interictal epileptiform discharges (IEDs) is clinically useful in the presurgical workup of epilepsy patients. We aimed to compare the performance of four different distributed magnetic source imaging (dMSI) approaches: Minimum norm estimate (MNE), dynamic statistical parametric mapping (dSPM), standardized low-resolution electromagnetic tomography (sLORETA), and coherent maximum entropy on the mean (cMEM). We also evaluated whether a simple average of maps obtained from multiple inverse solutions (Ave) can improve localization accuracy. Read More

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http://dx.doi.org/10.1002/hbm.24994DOI Listing
May 2020
5.969 Impact Factor

An Overview of the Electroencephalographic (EEG) Features of Epilepsy with Eyelid Myoclonia (Jeavons Syndrome).

Neurodiagn J 2020 Jun 5;60(2):113-127. Epub 2020 May 5.

Epilepsy Center, Neurological Institute, Cleveland Clinic , Cleveland, Ohio.

Epilepsy with eyelid myoclonia or Jeavons Syndrome is a unique idiopathic generalized epilepsy with onset in childhood. It is characterized by eyelid myoclonia which may be associated with absence seizures, eyelid closure-induced epileptiform discharges and/or seizures and photosensitivity. It is frequently underrecognized and misdiagnosed because it may be mistaken for some other type of generalized epilepsy or facial tic disorder. Read More

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http://dx.doi.org/10.1080/21646821.2020.1750879DOI Listing

[New applications of conventional EEG analysis].

Ideggyogy Sz 2020 Mar;73(3-4):99-110

Debreceni Egyetem, Kenézy Gyula Egyetemi Kórház, Neurológiai Osztály, Debrecen.

Neurophysiological research suggests that the so-called "standard" EEG analysis has been confronted with new diagnostic challenges. The findings mainly concern the occurrence, the neurophysiological and clinical significance of epileptiform EEG discharges in several neurological and psychiatric disorders. In addition to well-known interictal and ictal discharges, a growing number of recently recognized epileptiform phenomena have been described. Read More

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http://dx.doi.org/10.18071/isz.73.0099DOI Listing

Quantitative EEG Findings in Patients With Psychogenic Nonepileptic Seizures.

Clin EEG Neurosci 2020 May 4:1550059420918756. Epub 2020 May 4.

Department of Psychology, Uskudar University, Istanbul, Turkey.

. Psychogenic nonepileptic seizures (PNES), is one of the clinical manifestations of conversion disorder that epileptiform discharges do not accompany. Factors capable of increasing susceptibility to these seizures have not been adequately investigated yet. Read More

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http://dx.doi.org/10.1177/1550059420918756DOI Listing

Tablet-based electroencephalography diagnostics for patients with epilepsy in the West African Republic of Guinea.

Eur J Neurol 2020 May 2. Epub 2020 May 2.

Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.

Background And Purpose: Epilepsy is most common in lower-income settings where access to electroencephalography (EEG) is generally poor. A low-cost tablet-based EEG device may be valuable, but the quality and reproducibility of the EEG output are not established.

Methods: Tablet-based EEG was deployed in a heterogeneous epilepsy cohort in the Republic of Guinea (2018-2019), consisting of a tablet wirelessly connected to a 14-electrode cap. Read More

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http://dx.doi.org/10.1111/ene.14291DOI Listing
May 2020
4.055 Impact Factor

Critical slowing down as a biomarker for seizure susceptibility.

Nat Commun 2020 May 1;11(1):2172. Epub 2020 May 1.

Seer Medical, Melbourne, Australia.

The human brain has the capacity to rapidly change state, and in epilepsy these state changes can be catastrophic, resulting in loss of consciousness, injury and even death. Theoretical interpretations considering the brain as a dynamical system suggest that prior to a seizure, recorded brain signals may exhibit critical slowing down, a warning signal preceding many critical transitions in dynamical systems. Using long-term intracranial electroencephalography (iEEG) recordings from fourteen patients with focal epilepsy, we monitored key signatures of critical slowing down prior to seizures. Read More

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http://dx.doi.org/10.1038/s41467-020-15908-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195436PMC

Pathogenic variants in gene identified by clinical whole-genome sequencing.

Cold Spring Harb Mol Case Stud 2020 Jun 12;6(3). Epub 2020 Jun 12.

Center for Pediatric Genomic Medicine, Children's Mercy Hospital, Kansas City, Missouri 64108, USA.

Status epilepticus is not rare in critically ill intensive care unit patients, but its diagnosis is often delayed or missed. The mortality for convulsive status epilepticus is dependent on the underlying aetiologies and the age of the patients and thus varies from study to study. In this context, effective molecular diagnosis in a pediatric patient with a genetically heterogeneous phenotype is essential. Read More

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http://dx.doi.org/10.1101/mcs.a003970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304362PMC

Lateralized Rhythmic Delta Activity Synchronous with Hippocampal Epileptiform Discharges on Intracranial EEG.

Eur Neurol 2020 Apr 28:1-3. Epub 2020 Apr 28.

EEG & Epilepsy Unit, Division of Neurology, Department of Clinical Neurosciences, Geneva University Hospitals, Geneva, Switzerland.

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http://dx.doi.org/10.1159/000507394DOI Listing

REM-sleep related hypermotor seizures: Video documentation and ictal source imaging.

Brain Dev 2020 Aug 25;42(7):503-507. Epub 2020 Apr 25.

Department of Clinical Neurophysiology, Danish Epilepsy Centre, Dianalund, Denmark; Department of Clinical Neurophysiology, Aarhus University Hospital and Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.

Introduction: Rapid eye movement (REM) sleep has an inhibitory effect on epileptiform EEG discharges, and seizures occur extremely rarely in REM sleep.

Case Study: We present the case and video recordings of a 10-year-old boy, with sleep-related hypermotor seizures starting from REM sleep, identified from videoEEG recordings. The semiology comprised intense fear, tachycardia, tachypnea, followed by hypermotor manifestations. Read More

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http://dx.doi.org/10.1016/j.braindev.2020.04.003DOI Listing

Epileptiform discharges: Are we still defining them?

Neurology 2020 May 22;94(20):862-863. Epub 2020 Apr 22.

From the Department of Neurology (W.O.T.), Mayo Clinic, Jacksonville, FL; and Department of Pediatrics (R.A.S.), University of Michigan, Ann Arbor, MI.

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http://dx.doi.org/10.1212/WNL.0000000000009432DOI Listing

Criteria for defining interictal epileptiform discharges in EEG: A clinical validation study.

Neurology 2020 May 22;94(20):e2139-e2147. Epub 2020 Apr 22.

From the Department of Clinical Neurophysiology (M.A.K., L.D., V.S.H., H.T., S.B.), Aarhus University Hospital, Aarhus, Denmark; Department of Neurosurgery (P.G.L.), Rikshospitalet, Oslo University Hospital, Norway; Department of Neurosurgery (S.R.), University Hospital Erlangen, Germany; Department of Neurosurgery (S.R.), University Hospital Halle (Saale), Germany; Epilepsy Center Bethel (R.S.), Mara Hospital, Bielefeld, Germany; Krembil Brain Institute (R.W.), Toronto Western Hospital, University of Toronto, Canada; Department of Biostatistics (B.M.B.), Aarhus University, Denmark; Department of Research (M.S.), BESA GmbH, Gräfelfing, Germany; Department of Clinical Neurophysiology (S.B.), Danish Epilepsy Centre, Dianalund, Denmark; and Department of Clinical Medicine (S.B.), Aarhus University, Denmark.

Objective: To define and validate criteria for accurate identification of EEG interictal epileptiform discharges (IEDs) using (1) the 6 sensor space criteria proposed by the International Federation of Clinical Neurophysiology (IFCN) and (2) a novel source space method. Criteria yielding high specificity are needed because EEG over-reading is a common cause of epilepsy misdiagnosis.

Methods: Seven raters reviewed EEG sharp transients from 100 patients with and without epilepsy (diagnosed definitively by video-EEG recording of habitual events). Read More

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http://dx.doi.org/10.1212/WNL.0000000000009439DOI Listing

Electropositive seizures and non-convulsive status epilepticus in a critically ill patient with prior skull defect.

Epileptic Disord 2020 Apr;22(2):219-223

University of Ottawa, Ottawa, Canada.

Epileptiform discharges captured on routine scalp EEG typically carry a surface negative dipole. We present a patient whose continuous EEG recording in the intensive care setting captured frequent electropositive non-convulsive seizures. Epileptiform discharges with positive polarity are common in the pediatric population but have rarely been reported in adult patients. Read More

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http://dx.doi.org/10.1684/epd.2020.1147DOI Listing