4,451 results match your criteria Epileptiform Discharges

Safety and efficacy of cathodal transcranial direct current stimulation in patients with Lennox Gastaut Syndrome: An open-label, prospective, single-center, single-blinded, pilot study.

Seizure 2022 Jun 17;100:44-50. Epub 2022 Jun 17.

Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.

Purpose: Lennox-Gastaut Syndrome (SLG) is a severe form of childhood refractory epilepsy. Only one pilot study has been conducted using cathodal transcranial direct current stimulation (c-tDCs; 2mAx30minx5days) in LGS with promising results (-99% seizure reduction at 5 days). Our aim was to explore and replicate the efficacy and safety of 10 daily sessions of c-tDCs in SLG. Read More

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Omitting Hyperventilation in Electroencephalogram during the COVID-19 Pandemic May Reduce Interictal Epileptiform Discharges in Patients with Juvenile Myoclonic Epilepsy.

Brain Sci 2022 Jun 11;12(6). Epub 2022 Jun 11.

Comprehensive Epilepsy Center, Seirei Hamamatsu General Hospital, 2-12-12 Sumiyoshi, Nakaku, Hamamatsu 430-8558, Shizuoka, Japan.

Background: To prevent the spread of coronavirus disease 2019 (COVID-19), hyperventilation (HV) activation has been avoided in electroencephalograms (EEGs) since April 2020. The influence of omitting HV in EEG on epilepsy diagnosis remains uncertain for patients with epilepsies other than child absence epilepsy. We hypothesized that EEGs with HV would show more interictal epileptiform discharges (IEDs) than EEGs without HV in patients with juvenile myoclonic epilepsy (JME). Read More

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Prolongation of cortical sleep spindles during hippocampal interictal epileptiform discharges in epilepsy patients.

Epilepsia 2022 Jun 20. Epub 2022 Jun 20.

Dept of Neurology, National Institute of Mental Health, Budapest, Hungary.

Objective: Memory deficits are frequent among patients with epilepsies affecting the temporal lobe. Hippocampal interictal epileptic discharges (hIED), the presumed epileptic exaggeration of sharp wave-ripples (SWR) are known to contribute to memory dysfunctions, but the potential underlying mechanism is unknown. The precise temporal coordination between hippocampal SWRs and corticothalamic spindles during sleep is critical for memory consolidation. Read More

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Acute Disseminated Encephalomyelitis After SARS-CoV-2 Vaccination.

Am J Case Rep 2022 Jun 19;23:e936574. Epub 2022 Jun 19.

Department of Neurology, Northeast Georgia Medical Center, Gainesville, GA, USA.

BACKGROUND Acute disseminated encephalomyelitis (ADEM) is a disorder of the central nervous system which has been associated with preceding infection as well as vaccinations. We present a case of a 61-year-old woman with ADEM after receiving her initial vaccination for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This case highlights management of this acute condition. Read More

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Impact of high-density EEG in presurgical evaluation for refractory epilepsy patients.

Clin Neurol Neurosurg 2022 Jun 11;219:107336. Epub 2022 Jun 11.

Stanford University Department of Neurology and Neurological Sciences, Palo Alto, CA 94304, USA.

Objective: Electrical source localization (ESI) can help to identify the seizure onset zone or propagation zone, but it is unclear how dipole localization techniques influence surgical planning.

Methods: Patients who received a high density (HD)-EEG from 7/2014-7/2019 at Stanford were included if they met the following inclusion criteria: (1) adequate epileptiform discharges were recorded for source localization analysis, (2) underwent surgical treatment, which was at least 6 months before the survey. Interictal ESI was performed with the LORETA method on age matched MRIs. Read More

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An Investigation into the Correlation of Scalp Electrophysiological Findings with Preoperative Clinical and Imaging Findings in Patients with Focal Cortical Dysplasia.

Turk Neurosurg 2021 Dec 22. Epub 2021 Dec 22.

Istanbul University, Istanbul Faculty of Medicine, Departments of Neurology and Clinical Neurophysiology, Istanbul, Turkey.

Aim: In this study, patients who had epilepsy surgery and pathologically proven focal cortical dysplasia (FCD) were retrospectively evaluated to classify and discuss electroencephalography (EEG) findings in different pathological subtypes.

Material And Methods: This study included 19 refractory epilepsy patients who underwent surgery between 1999 and 2017 in the Istanbul Faculty of Medicine. Demographic data, preoperative examinations, scalp video EEGs, and postoperative outcomes were evaluated retrospectively. Read More

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December 2021


J Eng Res (Ponta Grossa) 2022 ;2(8)

Center for Collaborative Research in Health, Disparities - RCMI Program, University of Puerto Rico Medical Sciences, Campus, San Juan, Puerto Rico.

The brain is made up of billions of neurons, which control all actions performed by us. In epilepsy, the pattern order of brain signals is altered, causing epileptiform discharges in an individual's brain. Approximately 1% of the world population has epilepsy and, therefore, there is a need for studies that can help in the diagnosis and treatment of this disorder. Read More

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January 2022

Comparison of Electroencephalography in Patients With Seizures Caused by Neurosyphilis and Viral Encephalitis.

Front Neurol 2022 27;13:879643. Epub 2022 May 27.

Department of Neurology, Zhongshan Hospital, Xiamen University, Xiamen, China.

Background: Neurosyphilis (NS) lacks specificity in clinical and imaging features, and patients are frequently misdiagnosed as viral encephalitis when they present with seizures. This study aimed to compare electroencephalography (EEG) in patients with seizures resulting from the two diseases and provide guidance for differential diagnosis.

Methods: A retrospective study on patients diagnosed with neurosyphilis and viral encephalitis with seizures in the Department of Neurology, Zhongshan Hospital, Xiamen University from 2012 to 2020. Read More

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Temporal lobe interictal spikes disrupt encoding and retrieval of verbal memory: a subregion analysis.

Epilepsia 2022 Jun 16. Epub 2022 Jun 16.

Department of Neurology, Thomas Jefferson University, Philadelphia.

Objective: The medial temporal lobe (MTL) encodes and recalls memories and can be a predominant site for interictal spikes (IS) in patients with focal epilepsy. It is unclear if memory deficits are due to IS in the MTL producing a transient decline. Here, we investigated whether IS in the MTL subregions and lateral temporal cortex impact episodic memory encoding and recall. Read More

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[Possibilities of complex rehabilitation of young children with epilepsy and movement disorders].

Vopr Kurortol Fizioter Lech Fiz Kult 2022 ;99(3):25-31

Separate structural subdivision of the Russian Children's Clinical Hospital Federal State Autonomous Educational Institution of Higher Education Pirogov Russian National Research Medical University of the Ministry of Health of Russia, Moscow, Russia.

Epilepsy is a chronic disease characterized by recurrent, mostly unprovoked seizures with impaired motor, autonomic, mental or mental functions that occur as a result of excessive neuronal discharges in the gray matter of the cerebral cortex. The problem of the activity of medical rehabilitation for epilepsy in the professional community remains debatable, despite the obviousness of the arguments and judgments presented.

Purpose Of The Study: Development of an effective and safe complex for the rehabilitation of young children with epilepsy, accompanied by impaired movement function. Read More

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Late-Onset Lennox-Gastaut Syndrome with Chromosome 15q Duplication in Sisters.

J Neurosci Rural Pract 2022 Apr 8;13(2):348-350. Epub 2022 Mar 8.

Department of Neurology and Neurosurgery, Federal University of São Paulo (UNIFESP), São Paulo-SP, Brazil.

Our study reports two nontwin sisters with late-onset Lennox-Gastaut syndrome and chromosome 15q duplication, showing the evolution, symptoms, diagnosis, and treatment of these patients, with the aim of increasing knowledge about this extremely rare association. They had a variety of generalized seizures types, intellectual disability, electroencephalogram with generalized epileptiform discharges less than 3 Hz, dysmorphisms, and genetic studies with the presence of duplicated chromosome 15. Cases reported here may be related to chromosomal changes inherited from their asymptomatic mother. Read More

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High incidence of epileptiform activity in adults undergoing extracorporeal membrane oxygenation.

Clin Neurophysiol 2022 May 6;140:4-11. Epub 2022 May 6.

Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA. Electronic address:

Objective: The prevalence of seizures and other types of epileptiform brain activity in patients undergoing extracorporeal membrane oxygenation (ECMO) is unknown. We aimed to estimate the prevalence of seizures and ictal-interictal continuum patterns in patients undergoing electroencephalography (EEG) during ECMO.

Methods: Retrospective review of a prospective ECMO registry from 2011-2018 in a university-affiliated academic hospital. Read More

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Connectivity Mapping Using a Novel Loss-of-Function Zebrafish Epilepsy Model as a Powerful Strategy for Anti-epileptic Drug Discovery.

Front Mol Neurosci 2022 24;15:881933. Epub 2022 May 24.

Laboratory for Molecular Biodiscovery, KU Leuven, Leuven, Belgium.

Synaptic vesicle glycoprotein 2A (SV2A) regulates action potential-dependent neurotransmitter release and is commonly known as the primary binding site of an approved anti-epileptic drug, levetiracetam. Although several rodent knockout models have demonstrated the importance of SV2A for functional neurotransmission, its precise physiological function and role in epilepsy pathophysiology remains to be elucidated. Here, we present a novel knockout model in zebrafish, a vertebrate with complementary advantages to rodents. Read More

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-Related Epilepsy: Novel Mutations and Rare Phenotypes.

Front Mol Neurosci 2022 19;15:826183. Epub 2022 May 19.

Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.

Objectives: To expand the genotypes and phenotypes of sodium voltage-gated channel alpha subunit 1 (SCN1A)-related epilepsy.

Methods: We retrospectively collected the clinical and genetic information of 22 epilepsy patients (10 males, 12 females; mean: 9.2 ± 3. Read More

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[Clinical features of epilepsy in 5 children with Mowat-Wilson syndrome].

Y Ju T Y Ji

Zhonghua Er Ke Za Zhi 2022 Jun;60(6):578-582

Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.

To summarize and investigate the clinical characters of epilepsy in children with Mowat-Wilson syndrome (MWS), thus to improve the understanding of this disease. Clinical characters of epilepsy episodes in 5 children with MWS admitted to Department of Pediatrics, Peking University First Hospital from June to December 2020 were retrospectively reviewed. Clinical data including onset age of seizures, clinical features, characters of electroencephalogram (EEG), magnetic resonance imaging (MRI) findings, results of ZEB2 gene testing and responses to the anti-seizure medications (ASM) were summarized. Read More

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Typical absence status epilepticus in older people: syndromic delineation.

Epileptic Disord 2022 Jun;24(3):1-6

Objective We describe the clinical, electroencephalograph^ and neuroimaging findings of older patients with typical absence status epilepticus (ASE). Methods This investigation was a retrospective analysis of prospectively collected consecutive patients between January 2011 and October 2021. All patients ≥60 years with impairment of awareness and continuous generalized, rhythmic, synchronous and symmetric epileptiform discharges and normal background on video-electroencephalogram (vEEG) were included. Read More

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Epileptiform events and kainate receptor activity changes considerably during entorhinal cortex development, an ex vivo study.

Dev Neurosci 2022 May 31. Epub 2022 May 31.

Epilepsy is a commonly diagnosed neurological disease, which often develops already in childhood. The prominent feature of this dysfunction is the strong, unprovoked hypersynchronous neuronal activity of the brain, especially in the cortex, which appears in recurrent seizures. Previous studies indicated potential modulatory role of kainate types of glutamate receptors in this mechanism. Read More

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Continuous Video Electroencephalography (EEG) for Event Characterization in Critically Ill Children.

J Child Neurol 2022 Jun 29;37(7):562-567. Epub 2022 May 29.

Division of Epilepsy and Neurophysiology, 1862Boston Children's Hospital, Boston, MA, USA.

Objective: To determine features of paroxysmal events and background electroencephalographic (EEG) abnormalities associated with electroclinical seizures in critically ill children who undergo continuous video EEG to characterize clinical events.

Methods: This is a prospective study of critically ill children from July 2016 to October 2018. Non-neonates with continuous video EEG indication to characterize a clinical event were included. Read More

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Wernicke Encephalopathy Mimicking MELAS.

Josef Finsterer

Medicina (Kaunas) 2022 May 13;58(5). Epub 2022 May 13.

Neurology & Neurophysiology Center, Postfach 20, 1180 Vienna, Austria.

Objectives: a stroke-like lesion, the morphological equivalent of a stroke-like episode and the hallmark of mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome, have not been reported as manifestations of thiamine deficiency.

Case Report: a 62-year-old man with a history of chronic alcoholism was admitted after a series of epileptic seizures. Upon waking up from the coma, he presented with disorientation, confusion, confabulation, psychomotor agitation, aggressiveness, right hemianopsia, aphasia, and right hemineglect over weeks. Read More

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La Crosse Virus Neuroinvasive Disease in Children: A Contemporary Analysis of Clinical/Neurobehavioral Outcomes and Predictors of Disease Severity.

Clin Infect Dis 2022 May 24. Epub 2022 May 24.

Department of Pediatrics, Nationwide Children's Hospital and The Ohio State University, Columbus, OH, USA.

Background: La Crosse virus (LACV) is the most common neuroinvasive arboviral infection in children in the United States. However, data regarding predictors of disease severity and neurologic outcome are limited. Additionally, long-term neurologic and neurobehavioral outcomes remain relatively sparse. Read More

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Case 302: Supratentorial Lymphocytic Inflammation with Parenchymal Perivascular Enhancement Responsive to Steroids.

Radiology 2022 06;303(3):726-730

From the Department of Radiology, Neuroradiology Section, University of Arkansas for Medical Sciences, Little Rock, Ark (S.V.); Department of Clinical Imaging, Hamad General Hospital (L.A.), and Department of Neuroradiology, Neuroscience Institute (M.A., A.H.E.B.), Hamad Medical, PO Box 3050, Alsadd, Doha, Qatar; and Department of Clinical Radiology, Weill Cornell Medicine, Doha, Qatar (A.H.E.B.).

History: Part one of this case appeared 4 months previously and may contain larger images. A 21-year-old immunocompetent man who was a long-term resident of Qatar presented to the emergency department with recurrent episodes of unprovoked generalized tonic-clonic seizures lasting 2-3 minutes that spontaneously resolved and were associated with postictal confusion. The patient also had progressive mild diplopia, intermittent dizziness, and numbness in the left arm over the course of 3 months. Read More

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Long-term changes in electroencephalogram findings in a girl with a nonsense SMC1A variant: A case report.

Brain Dev 2022 May 16. Epub 2022 May 16.

Department of Mental Retardation and Birth Defect Research, NCNP, Kodaira, Tokyo, Japan; Medical Genome Center, NCNP, Kodaira, Tokyo, Japan.

Introduction: Pathogenic truncating variants in SMC1A, which is located on chromosome Xp11.2, are known to cause infantile-onset epilepsy and severe intellectual disability in girls. Several studies have reported a correlation between SMC1A truncations and seizure clustering; however, the associated electroencephalogram (EEG) patterns remain largely unknown. Read More

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Salzburg consensus criteria are associated with long-term outcome after non-convulsive status epilepticus.

Seizure 2022 Jul 10;99:28-35. Epub 2022 May 10.

Research Unit for Neurology, Odense University Hospital, Odense, Denmark; University of Southern Denmark, Odense, Denmark. Electronic address:

Purpose: To investigate differences in long-term survival and short-term neurological deficits in adult patients fulfilling either sub-criterion of the Salzburg Consensus Criteria (SC) for non-convulsive status epilepticus (NCSE).

Methods: We retrospectively identified a cohort of patients with first-time NCSE epilepticus at Odense University Hospital from 2014 to 2017. Results of electroencephalograms at admission were dichotomized according to the SC (more than 25 epileptiform discharges/10 s was defined as the fast criterion), and groups were compared statistically through survival analysis and in a logistic regression model adjusting for established prognostic determinants in status epilepticus. Read More

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Magnetoencephalography-identified preictal spiking correlates to preictal spiking on stereotactic EEG.

Epilepsy Behav Rep 2022 24;19:100538. Epub 2022 Mar 24.

Department of Neurology, Spectrum Health, Grand Rapids, MI, United States.

Magnetoencephalography (MEG) is a noninvasive diagnostic modality that directly measures neuronal signaling by recording the magnetic field created from dendritic, intracellular, electrical currents of the neuron at the surface of the head. In clinical practice, MEG is used in the epilepsy presurgical evaluation and most commonly is an "interictal" study that can provide source localization of spike-wave discharges. However, seizures may be recorded during MEG ("ictal MEG") and mapping of these discharges may provide more accurate localization of the seizure onset zone. Read More

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Contributions of Magnetoencephalography to Understanding Mechanisms of Generalized Epilepsies: Blurring the Boundary Between Focal and Generalized Epilepsies?

Front Neurol 2022 27;13:831546. Epub 2022 Apr 27.

Department of Neurology, University of Pittsburgh Comprehensive Epilepsy Center (UPCEC), University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, United States.

According to the latest operational 2017 ILAE classification of epileptic seizures, the generalized epileptic seizure is still conceptualized as "originating at some point within and rapidly engaging, bilaterally distributed networks." In contrast, the focal epileptic seizure is defined as "." Hence, one of the main concepts of "generalized" and "focal" epilepsy comes from EEG descriptions before the era of source localization, and a presumed simultaneous bilateral onset and bi-synchrony of epileptiform discharges remains a hallmark for generalized seizures. Read More

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Sleep and Temporal Lobe Epilepsy - Associations, Mechanisms and Treatment Implications.

Front Hum Neurosci 2022 26;16:849899. Epub 2022 Apr 26.

Division of Epilepsy and Sleep Medicine, Queen's University, Kingston, ON, Canada.

In this systematic review, we aim to describe the association between temporal lobe epilepsy (TLE) and sleep, with bidirectional links in mechanisms and therapeutic aspects. Sleep stages may variably impact seizure occurrence, secondary generalization and the development, frequency and distribution of interictal epileptiform discharges. Conversely, epilepsy affects sleep micro- and macroarchitecture. Read More

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Modulation of epileptiform activity by three subgroups of GABAergic interneurons in mouse somatosensory cortex.

Epilepsy Res 2022 Jul 28;183:106937. Epub 2022 Apr 28.

Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Electronic address:

4-Aminopyridine (4-AP) induces ictal-like epileptiform discharges in a variety of brain regions. These events are associated with enhanced inhibitory and excitatory synaptic neurotransmission. The relative contribution of specific subclasses of GABAergic interneurons (INs) to epileptiform activity in the 4-AP model is not well characterized. Read More

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Acute physiologic prediction of pediatric post-traumatic epilepsy.

Epilepsy Res 2022 Jul 27;183:106935. Epub 2022 Apr 27.

Barrow Neurological Institute at Phoenix Children's Hospital, 1919 E. Thomas Road, Ambulatory Building, 3rd Floor, Phoenix, AZ 85016, USA. Electronic address:

Objective: Post-traumatic epilepsy (PTE) is a known complication of traumatic brain injury (TBI). Limited physiologic biomarkers have been investigated in relation to pediatric PTE. Our aim is to identify clinical, physiologic and neuroimaging biomarkers predictive of pediatric PTE arising during the acute care phase after injury. Read More

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