3,728 results match your criteria Epileptiform Discharges


EEG changes in patients on antipsychotic therapy: A systematic review.

Epilepsy Behav 2019 Apr 15;95:1-9. Epub 2019 Apr 15.

Department of Neuroscience, Monash Medical Centre, Clayton, Victoria, Australia; School of Clinical Sciences at Monash Health, Department of Medicine, Monash University, Melbourne, Victoria, Australia; Department of Medicine, St. Vincent's Hospital, University of Melbourne, Melbourne, Australia. Electronic address:

Objectives: The objective of the study was to characterize the electroencephalogram (EEG) changes associated with different antipsychotic medications based on the evidence from the literature.

Methods: A systematic search of the databases Medline, PsycINFO, and PubMed was conducted. The Preferred Items Reporting for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed in the construction of this systematic review. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15255050183104
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http://dx.doi.org/10.1016/j.yebeh.2019.02.005DOI Listing
April 2019
3 Reads

Sleep, oscillations, interictal discharges, and seizures in human focal epilepsy.

Neurobiol Dis 2019 Apr 11;127:545-553. Epub 2019 Apr 11.

Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.

Bidirectional interactions between sleep and epilepsy are known since antiquity, however only the introduction of the method of electroencephalography (EEG) in 1929 contributed to objectively investigate and further unravel these obvious clinical relationships. Despite the increasing evidence over the last century, certain aspects of epilepsy and sleep interactions are still incompletely or not well understood. This article discusses the influence of sleep on adult focal epilepsy as assessed objectively via EEG, and highlights new developments of the last decade regarding sleep microstructure and new markers of the epileptogenic zone such as high-frequency oscillations >80 Hz. Read More

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http://dx.doi.org/10.1016/j.nbd.2019.04.007DOI Listing
April 2019
1 Read

Music-Enhanced Analgesia and Antiseizure Activities in Animal Models of Pain and Epilepsy: Toward Preclinical Studies Supporting Development of Digital Therapeutics and Their Combinations With Pharmaceutical Drugs.

Front Neurol 2019 27;10:277. Epub 2019 Mar 27.

Department of Medicinal Chemistry, University of Utah, Salt Lake, UT, United States.

Digital therapeutics (software as a medical device) and mobile health (mHealth) technologies offer a means to deliver behavioral, psychosocial, disease self-management and music-based interventions to improve therapy outcomes for chronic diseases, including pain and epilepsy. To explore new translational opportunities in developing digital therapeutics for neurological disorders, and their integration with pharmacotherapies, we examined analgesic and antiseizure effects of specific musical compositions in mouse models of pain and epilepsy. The music playlist was created based on the modular progression of Mozart compositions for which reduction of seizures and epileptiform discharges were previously reported in people with epilepsy. Read More

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http://dx.doi.org/10.3389/fneur.2019.00277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446215PMC
March 2019
1 Read

The yield of electroencephalography in syncope.

Ideggyogy Sz 2019 Mar;72(3-4):111-114

Ankara Numune Training and Research Hospital, Neurology Department, Ankara, Turkey.

Background And Purpose: Syncope is defined as a brief transient loss of consciousness due to cerebral hypoperfusion. Although the diagnosis of syncope is based on a thorough history and examination, electroencaphalography (EEG) is also an important investigational tool in the differential diagnosis in this group of patients. In this study we aimed to identify the diagnostic value of EEG in patients with syncope. Read More

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http://dx.doi.org/10.18071/isz.72.0111DOI Listing

A Straw Can Break a Neural Network's Back and Lead to Seizures-But Only When Delivered at the Right Time.

Epilepsy Curr 2019 Mar-Apr;19(2):115-116

Loss of Neuronal Network Resilience Precedes Seizures and Determines the Ictogenic Nature of Interictal Synaptic Perturbations Chang WC, Kudlacek J, Hlinka J, et al. Nat Neurosci. 2018; 21(12):1742-1752. Read More

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http://dx.doi.org/10.1177/1535759719835349DOI Listing
April 2019
1 Read

Electroencephalographic Patterns During Routine Polysomnography in Childhood and Association With Future Epilepsy Diagnosis.

J Clin Sleep Med 2019 Apr 15;15(4):553-562. Epub 2019 Apr 15.

Department of Pediatrics, Section of Pediatric Neurology and Developmental Neuroscience, Baylor College of Medicine and Texas Children's Hospital, Houston, Texas.

Study Objectives: Evaluate the frequency of abnormal electroencephalograph (EEG) records during pediatric polysomnography (PSG) at a tertiary referral center and determine frequency with which these records may predict future seizures and a diagnosis of epilepsy.

Methods: Retrospective review of all pediatric PSG reports from 2013 was performed. Demographics, medical history, indications, diagnoses, and EEG reports were collected. Read More

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http://dx.doi.org/10.5664/jcsm.7712DOI Listing
April 2019
3 Reads

Insulin attenuates epileptiform discharge-induced oxidative stress by increasing zinc-α2-glycoprotein in primary cultured cortical neurons.

Neuroreport 2019 May;30(8):580-585

Zinc-α2-glycoprotein (ZAG) is decreased in neurons of epilepsy patients and models. Either insulin or overexpressing ZAG suppresses seizure and epileptiform discharges. ZAG is known to influence insulin sensitivity of tissues, but whether insulin regulates ZAG is unknown. Read More

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http://dx.doi.org/10.1097/WNR.0000000000001250DOI Listing
May 2019
1 Read
1.644 Impact Factor

Rasmussen's Epileptogenic Encephalitis in a Tropical Country.

J Pediatr Neurosci 2018 Oct-Dec;13(4):490-495

Department of Neurology, Campus University Teaching Hospital, University of Lomé, Lomé, Togo.

Background: Encephalitis of Rasmussen is an inflammatory hemiencephalopathy of unknown etiology. It is a cause of drug-resistant epilepsy.

Aim: To report two cases of Rasmussen's encephalitis (RE) in a low-income setting. Read More

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http://dx.doi.org/10.4103/JPN.JPN_51_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413596PMC
April 2019
3 Reads

MEF2C-related epilepsy: Delineating the phenotypic spectrum from a novel mutation and literature review.

Seizure 2019 Mar 22. Epub 2019 Mar 22.

Division of Neurology, Department of Paediatrics, The Hospital for Sick Children, Toronto, ON, Canada.

Purpose: MEF2C-related epilepsy has been poorly described in the literature, despite a consistent MEF2C haploinsufficiency phenotype characterized by severe language impairment and motor delay (MIM# 613443). We aimed to delineate the spectrum of electroclinical manifestations of MEF2C-related epilepsy from an illustrative case and literature review.

Methods: A retrospective chart review of our case was performed followed by a literature review on PubMed and OMIM. Read More

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http://dx.doi.org/10.1016/j.seizure.2019.03.015DOI Listing
March 2019
2 Reads

Neuronal ceroid lipofuscinosis type-11 in an adolescent.

Brain Dev 2019 Mar 25. Epub 2019 Mar 25.

Department of Radiology, KAHER University's J N Medical College, Belgaum, India.

Neuronal ceroid lipofuscinosis (NCL) is a group of progressive neurodegenerative disorders characterized by intracellular accumulation of ceroid lipopigments. Based on gene defect of NCL-associated proteins, 14 types of NCL have been described till date. NCL type 11 was first described in 2014 in two siblings as adult-onset NCL and was found to be due to a homozygous progranulin gene mutation. Read More

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http://dx.doi.org/10.1016/j.braindev.2019.03.004DOI Listing
March 2019
1 Read

Electroencephalography in Epilepsy Evaluation.

Continuum (Minneap Minn) 2019 04;25(2):431-453

Purpose Of Review: Epilepsy is a heterogeneous disorder that is often associated with abnormal electroencephalogram (EEG) findings. This article provides an overview of common EEG findings in epileptic disorders. The physiologic basis of EEG and intracranial EEG studies is also discussed. Read More

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http://dx.doi.org/10.1212/CON.0000000000000705DOI Listing
April 2019
3 Reads

Automatic Analysis of EEGs Using Big Data and Hybrid Deep Learning Architectures.

Front Hum Neurosci 2019 12;13:76. Epub 2019 Mar 12.

The Neural Engineering Data Consortium, Temple University, Philadelphia, PA, United States.

Brain monitoring combined with automatic analysis of EEGs provides a clinical decision support tool that can reduce time to diagnosis and assist clinicians in real-time monitoring applications (e.g., neurological intensive care units). Read More

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http://dx.doi.org/10.3389/fnhum.2019.00076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423064PMC

Scalp recorded spike ripples predict seizure risk in childhood epilepsy better than spikes.

Brain 2019 Mar 25. Epub 2019 Mar 25.

Massachusetts General Hospital, Department of Neurology, Boston, MA, USA.

In the past decade, brief bursts of fast oscillations in the ripple range have been identified in the scalp EEG as a promising non-invasive biomarker for epilepsy. However, investigation and clinical application of this biomarker have been limited because standard approaches to identify these brief, low amplitude events are difficult, time consuming, and subjective. Recent studies have demonstrated that ripples co-occurring with epileptiform discharges ('spike ripple events') are easier to detect than ripples alone and have greater pathological significance. Read More

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https://academic.oup.com/brain/advance-article/doi/10.1093/b
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http://dx.doi.org/10.1093/brain/awz059DOI Listing
March 2019
15 Reads

Age-Dependent Electrocorticogram Dynamics and Epileptogenic Responsiveness in Rats Subjected to Prenatal Hypoxia.

Dev Neurosci 2019 Mar 22:1-11. Epub 2019 Mar 22.

I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Saint Petersburg, Russian Federation,

Using electrocorticogram (ECoG) analysis, we compared age-related dynamics of general neuronal activity and convulsive epileptiform responsiveness induced by intracortical microinjections of 4-aminopyridine (4-AP) in control Wistar rats and those subjected to prenatal hypoxia (Hx; E14; 7% O2, 3 h). The studies were carried out in three age periods roughly corresponding to childhood (P20-27), adolescence (P30-45), and adulthood (P90-120). It was found that in the process of postnatal development of the control rats, the peak of the ECoG power spectrum density (PSD) of the theta rhythm during wakefulness shifted from the low to the higher frequency, while in the Hx rats this shift had the opposite direction. Read More

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http://dx.doi.org/10.1159/000497224DOI Listing

Effect of short-term transcutaneous trigeminal nerve stimulation on EEG activity in drug-resistant epilepsy.

J Neurol Sci 2019 May 14;400:90-96. Epub 2019 Mar 14.

Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy. Electronic address:

Background: Transcutaneous trigeminal nerve stimulation (TNS) has antiepileptic effects in patients with drug-resistant epilepsy (DRE). However, whether and how TNS is able to modulate the electroencephalogram (EEG) background activity in patients with DRE is still unknown.

Objectives: To investigate the effect of short-term TNS on EEG background activity in DRE by qualitative and quantitative analyses. Read More

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http://dx.doi.org/10.1016/j.jns.2019.03.004DOI Listing
May 2019
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Seizures in patents with primary central nervous system lymphoma: Prevalence and associated features.

J Neurol Sci 2019 May 14;400:34-38. Epub 2019 Mar 14.

Department of Neurology, Medical University of South Carolina, Charleston, SC, USA.

Objective: Primary central nervous system (CNS) lymphoma (PCNSL) is a rare, aggressive, yet highly chemosensitive form of non-Hodgkin lymphoma which is associated with significant morbidity. Very little is known about the long-term risk for and features of seizures associated with this condition.

Methods: We performed a retrospective and longitudinal analysis of 36 patients with pathologically and radiographically confirmed primary CNS lymphoma to evaluate the incidence, prevalence and features associated with seizures. Read More

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http://dx.doi.org/10.1016/j.jns.2019.03.011DOI Listing
May 2019
2 Reads

Optimum recording time of routine electroencephalogram for adults with epilepsy

Turk J Med Sci 2019 04 18;49(2):635-638. Epub 2019 Apr 18.

Background/aim: This study aimed to reveal the optimum recording time of routine electroencephalogram (EEG) for adults with epilepsy.

Materials And Methods: In this clinical observational study we investigated features of paroxysms that emerged in EEGs recorded for 45 min in adults with epilepsy.

Results: Paroxysms were detected in 38. Read More

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http://dx.doi.org/10.3906/sag-1810-117DOI Listing

Epileptological aspects of juvenile neuronal ceroid lipofuscinosis (CLN3 disease) through the lifespan.

Epilepsy Behav 2019 Mar 15;94:59-64. Epub 2019 Mar 15.

Department of Neurology and Clinical Neurophysiology, St. Olav's University Hospital, Trondheim, Norway; Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.

Purpose: Juvenile neuronal ceroid lipofuscinosis (CLN3 disease) is the most common neurodegenerative disorder in childhood with survival until young adult age. Visual loss is followed by epilepsy, cognitive, neuropsychiatric, and motor symptoms. We have studied the evolution of electroencephalographic (EEG) and seizure characteristics. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.02.020DOI Listing
March 2019
1 Read

Levetiracetam versus carbamazepine in treatment of rolandic epilepsy.

Epilepsy Behav 2019 Mar 15;94:1-8. Epub 2019 Mar 15.

Cobel Darou, Tehran, Iran. Electronic address:

Purpose: The aim of the current study was to systematically review the literature to compare the efficacy of levetiracetam (LEV) with that of carbamazepine (CBZ) to control seizures and reduce the burden of interictal epileptiform discharges in children with rolandic epilepsy (RE) and also to compare their tolerability.

Methods: We searched the electronic database PubMed on January 9, 2019 for original articles that included the following English-language search terms in the title: "Rolandic epilepsy" OR "benign childhood epilepsy with centrotemporal spikes" since 2000. We concentrated our review on three main areas: 1. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.02.009DOI Listing
March 2019
1 Read

7,8-Dihydroxyflavone potentiates ongoing epileptiform activity in mice brain slices.

Neurosci Lett 2019 Mar 14;703:25-31. Epub 2019 Mar 14.

Department of Biophysics, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.

In the central nervous system, Tropomyosin-receptor-kinase B (TrkB) signaling is involved in neuronal survival, differentiation as well as in regulation of synaptic transmission and excitability. As its powerful potential to modulate neuronal functions, TrkB pathway is an attractive target for novel drugs and treatment of common neurological disorders. 7,8-Dihydroxyflavone (DHF), a TrkB receptor agonist, has similar properties with neurotrophin Brain Derived Neurotropic Factor (BDNF). Read More

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http://dx.doi.org/10.1016/j.neulet.2019.03.013DOI Listing

Inhibition of microRNA-34a Suppresses Epileptiform Discharges Through Regulating Notch Signaling and Apoptosis in Cultured Hippocampal Neurons.

Neurochem Res 2019 Mar 15. Epub 2019 Mar 15.

Department of Pediatrics, Jinan Central Hospital, Shandong University, Number 105, Jiefang Road, Lixia District, Jinan, 250012, Shandong, China.

Epilepsy is characterized by recurrent unprovoked seizures and some seizures can cause neuronal apoptosis, which is possible to make contributions to the epilepsy phenotype, impairments in cognitive function or even epileptogenesis. Moreover, many studies have indicated that microRNA-34a (miRNA-34a) is involved in apoptosis through regulating Notch signaling. However, whether miRNA-34a participates in neuronal apoptosis after seizures remain unclear. Read More

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http://dx.doi.org/10.1007/s11064-019-02772-xDOI Listing
March 2019
2.593 Impact Factor

Investigating the Effect of Short Term Responsive VNS Therapy on Sleep Quality Using Automatic Sleep Staging.

IEEE Trans Biomed Eng 2019 Mar 8. Epub 2019 Mar 8.

Objective: The goal of this work is to objectively evaluate the effectiveness of responsive (or closed-loop) Vagus nerve stimulation (VNS) therapy in sleep quality in patients with medically refractory epilepsy.

Methods: Using quantitative features obtained from electroencephalography (EEG), we first developed a new automatic sleep-staging framework that consists of a multi-class support vector machine (SVM) classification based on a decision tree approach. To train and evaluate the performance of the framework, we used polysomnographic data of 23 healthy subjects from the PhysioBank database where the sleep stages have been visually annotated. Read More

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http://dx.doi.org/10.1109/TBME.2019.2903987DOI Listing
March 2019
2 Reads

Long-term prognosis of epilepsy in patients with cerebral palsy.

Dev Med Child Neurol 2019 Mar 10. Epub 2019 Mar 10.

Division of Child Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University, Yonago, Japan.

Aim: To assess the long-term natural course and prognosis of epilepsy in patients with cerebral palsy (CP).

Method: We retrospectively collected data for 72 patients (36 males, 36 females) with CP who had epilepsy who visited our institutions between 1980 and 2015. The data from medical records, electroencephalography (EEG), and neuroimaging findings were reviewed. Read More

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http://dx.doi.org/10.1111/dmcn.14188DOI Listing
March 2019
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Diagnostic Yield of 2-Hour EEG Is Similar With 30-Minute EEG in Patients With a Normal 30-Minute EEG.

J Clin Neurophysiol 2019 Feb 27. Epub 2019 Feb 27.

Department of Neurology and Neurotherapeutics, University of Texas Southwestern, Dallas, U.S.A.

Purpose: Current literature suggests that longer duration of EEG recording increases the yield of detecting interictal epileptiform discharges. However, optimal duration for a repeat study in patients with initially normal 30-minute EEG is not clear. Thus, the purpose of this study is to determine whether a 2-hour EEG has a diagnostic advantage over a routine 30-minute EEG in detecting epileptiform abnormalities in patients who had a first normal 30-minute EEG. Read More

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http://dx.doi.org/10.1097/WNP.0000000000000567DOI Listing
February 2019

Continuous EEG Monitoring-The Neurologist's Crystal Ball.

Authors:
Aatif M Husain

Epilepsy Curr 2019 Jan 30;19(1):24-26. Epub 2019 Jan 30.

Time to Epileptiform Activity and EEG Background Recovery Are Independent Predictors After Cardiac Arrest Westhall E, Rose I, Rundgren M, Bro-Jeppesen J, Kjaergaard J, Hassager C, Lindehammar H, Horn J, Ullen S, Nielsen N, Friberg H, Cronberg T. Clin Neurophysiol. 2018;129:1660-1668. Read More

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http://dx.doi.org/10.1177/1535759718822037DOI Listing
January 2019
2 Reads

Muscle spasm-induced exothermia in dystonic cerebral palsy: uncommon and frequently misdiagnosed condition.

BMJ Case Rep 2019 Mar 4;12(3). Epub 2019 Mar 4.

Department of Medicine, Section of Hypertension, University of the Philippines - Philippine General Hospital, Manila, Philippines.

A known cerebral palsy young man presented with prolonged bouts of generalised body movements associated with high-grade fever without any localising signs of infection, requiring multiple hospital admissions over several months. All septic work-ups, including a lumbar puncture, were negative. Serum chemistry was consistent with rhabdomyolysis. Read More

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http://dx.doi.org/10.1136/bcr-2018-227488DOI Listing
March 2019
5 Reads

Slit Ventricle Syndrome Leads to a 10-year history of Repetitive Transient Central Herniation Masquerading as Seizures: A Hydrocephalus Case Report.

World Neurosurg 2019 Mar 1. Epub 2019 Mar 1.

University of Wisconsin Hospital and Clinics, Neurosurgery Department. Madison, Wisconsin.

Background: Slit-ventricle syndrome (SVS) is a recognized complication of ventricular shunt malfunction, resulting in cyclical symptoms without ventricular dilatation. We present a case of SVS with transient, repetitive, and progressive signs of brainstem herniation evidenced by pupillary dilatation, posturing, and unresponsiveness, with diffuse voltage attenuation on EEG.

Case Description: 32-year-old female with history of hydrocephalus and VP shunt placement at 9 months of age. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.02.106DOI Listing
March 2019
2 Reads

Low-intensity ultrasound suppresses low-Mg-induced epileptiform discharges in juvenile mouse hippocampal slices.

J Neural Eng 2019 Feb 28;16(3):036006. Epub 2019 Feb 28.

School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, People's Republic of China.

Objective: It has been shown that low-intensity ultrasound (LIUS) can suppress seizures in some laboratory studies. However, the mechanism of the suppression effect of LIUS remains unclear. The goal of this study is to investigate the modulation effects of focused LIUS on epileptiform discharges in mouse hippocampal slices as well as the underlying mechanism. Read More

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http://iopscience.iop.org/article/10.1088/1741-2552/ab0b9a
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http://dx.doi.org/10.1088/1741-2552/ab0b9aDOI Listing
February 2019
5 Reads

Atypical Interictal Epileptiform Discharges in Electroencephalography.

J Epilepsy Res 2018 Dec 31;8(2):55-60. Epub 2018 Dec 31.

King Khalid Hospital (KKH), Hail, Saudi Arabia.

Background And Purpose: A great deal of attention has been focused on "typical" interictal epileptiform discharges (IEDs) in the electroencephalography (EEG) literature. However, there is a paucity of data on "atypical" IEDs, namely, positive sharp waves (PSWs), focal triphasic sharp waves and spikes (FTSWs), sharp slow waves (SSWs), bifid spikes, and "notched" delta. In this present study, we sought to address the pathophysiology, characteristics, and diagnostic significance of "atypical" IEDs in clinical neuroscience. Read More

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http://j-epilepsy.org/journal/view.php?doi=10.14581/jer.1800
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http://dx.doi.org/10.14581/jer.18009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374539PMC
December 2018
3 Reads

Interictal and ictal source localization for epilepsy surgery using high-density EEG with MEG: a prospective long-term study.

Brain 2019 Apr;142(4):932-951

School of Health Sciences, Swinburne University of Technology, Hawthorn, Australia.

Drug-resistant focal epilepsy is a major clinical problem and surgery is under-used. Better non-invasive techniques for epileptogenic zone localization are needed when MRI shows no lesion or an extensive lesion. The problem is interictal and ictal localization before propagation from the epileptogenic zone. Read More

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http://dx.doi.org/10.1093/brain/awz015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459284PMC
April 2019
1 Read

Quinidine Therapy for Lennox-Gastaut Syndrome With Mutation. A Case Report and Literature Review.

Front Neurol 2019 5;10:64. Epub 2019 Feb 5.

Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.

Mutations in the Potassium channel subfamily T member 1 () gene have been reported in a range of epileptic encephalopathies. Here we report the case of a 12-year-old male suffering from multiple types of epileptic seizures and cognitive decline from the age of 10. The patient had four types of epileptic seizures, including tonic seizures, atypical absence seizures, myoclonic seizures, and generalized tonic-clonic seizures. Read More

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http://dx.doi.org/10.3389/fneur.2019.00064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370615PMC
February 2019
2 Reads

Controlling seizure propagation in large-scale brain networks.

PLoS Comput Biol 2019 02 25;15(2):e1006805. Epub 2019 Feb 25.

Aix Marseille Université, Inserm, Institut de Neurosciences des Systèmes, UMR_S 1106, 13005, Marseille, France.

Information transmission in the human brain is a fundamentally dynamic network process. In partial epilepsy, this process is perturbed and highly synchronous seizures originate in a local network, the so-called epileptogenic zone (EZ), before recruiting other close or distant brain regions. We studied patient-specific brain network models of 15 drug-resistant epilepsy patients with implanted stereotactic electroencephalography (SEEG) electrodes. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1006805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405161PMC
February 2019
1 Read

Reassessing the impact of intraoperative electrocorticography on postoperative outcome of patients undergoing standard temporal lobectomy for MRI-negative temporal lobe epilepsy.

J Neurosurg 2019 Feb 22:1-10. Epub 2019 Feb 22.

Departments of2Neurologic Surgery.

OBJECTIVEAlmost 30% of the patients with suspected temporal lobe epilepsy (TLE) have normal results on MRI. Success rates for resection of MRI-negative TLE are less favorable, ranging from 36% to 76%. Herein the authors describe the impact of intraoperative electrocorticography (ECoG) augmented by opioid activation and its effect on postoperative seizure outcome. Read More

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http://dx.doi.org/10.3171/2018.11.JNS182124DOI Listing
February 2019
3 Reads

Establishment and utility assessment of posterior reversible encephalopathy syndrome early warning scoring (PEWS) scale establishment and utility assessment of PEWS scale.

BMC Neurol 2019 Feb 21;19(1):30. Epub 2019 Feb 21.

Department of Pediatrics, Chinese PLA General Hospital, Beijing, 100853, People's Republic of China.

Background: Posterior reversible encephalopathy syndrome (PRES) is a complication that occurs during various diseases' treatment. Imaging examination is the gold standard for diagnosis. PRES frequently occurrence in patients with hematological malignancies results in poorer prognosis and higher mortality. Read More

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http://dx.doi.org/10.1186/s12883-019-1247-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385440PMC
February 2019
3 Reads

Transplanting GABAergic Neurons Differentiated from NSCs into Hippocampus Inhibits Seizures and Epileptiform Discharges in Pilocarpine-Induced Temporal Lobe Epilepsy Model.

World Neurosurg 2019 Feb 18. Epub 2019 Feb 18.

Neurology Affiliated Hospital of Guizhou Medical University, Guizhou, Guiyang City, China, 550004. Electronic address:

Objective: This study aimed to explore whether intra-hippocampal transplantation of GABAergic neurons generated in vitro ameliorated seizures and epileptiform discharges via increasing GABA-associated inhibition mediated by the addition of new GABAergic neurons.

Methods: NSCs isolated from newborn rats were induced and differentiated into GABAergic neurons. A total of 36 Pilocarpine-induced pharmacoresistant epileptic rats were divided into three groups: PBS group, NSCs group, and GABAergic neurons group (GABA group), with an additional ten normal rats used (NRC group). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193035
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http://dx.doi.org/10.1016/j.wneu.2019.01.245DOI Listing
February 2019
7 Reads
2.417 Impact Factor

Beta oscillations in the sensorimotor cortex correlate with disease and remission in benign epilepsy with centrotemporal spikes.

Brain Behav 2019 Mar 20;9(3):e01237. Epub 2019 Feb 20.

Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts.

Introduction: Benign epilepsy with centrotemporal spikes (BECTS) is a common form of childhood epilepsy with the majority of those afflicted remitting during their early teenage years. Seizures arise from the lower half of the sensorimotor cortex of the brain (e.g. Read More

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http://doi.wiley.com/10.1002/brb3.1237
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http://dx.doi.org/10.1002/brb3.1237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422718PMC
March 2019
8 Reads

Brain metabolism modulates neuronal excitability in a mouse model of pyruvate dehydrogenase deficiency.

Sci Transl Med 2019 Feb;11(480)

Rare Brain Disorders Program, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Glucose is the ultimate substrate for most brain activities that use carbon, including synthesis of the neurotransmitters glutamate and γ-aminobutyric acid via mitochondrial tricarboxylic acid (TCA) cycle. Brain metabolism and neuronal excitability are thus interdependent. However, the principles that govern their relationship are not always intuitive because heritable defects of brain glucose metabolism are associated with the paradoxical coexistence, in the same individual, of episodic neuronal hyperexcitation (seizures) with reduced basal cerebral electrical activity. Read More

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http://dx.doi.org/10.1126/scitranslmed.aan0457DOI Listing
February 2019

Neuronal spiking activity highlights a gradient of epileptogenicity in human tuberous sclerosis lesions.

Clin Neurophysiol 2019 Apr 30;130(4):537-547. Epub 2019 Jan 30.

Centre de Recherche Cerveau et Cognition, Université de Toulouse, Université Paul Sabatier Toulouse, Toulouse F-31330, France; Centre National de la Recherche Scientifique, CerCo, UMR 5549, Toulouse F-31052, France.

Objective: The mechanisms underlying epileptogenicity in tuberous sclerosis complex (TSC) are poorly understood.

Methods: We analysed neuronal spiking activity (84 neurons), fast ripples (FRs), local field potentials and intracranial electroencephalogram during interictal epileptiform discharges (IEDs) in the tuber and perituber of a patient using novel hybrid electrodes equipped with tetrodes.

Results: IEDs were recorded in the tuber and perituber. Read More

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http://dx.doi.org/10.1016/j.clinph.2018.12.013DOI Listing
April 2019
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Alternative Diagnosis of Epilepsy in Children Without Epileptiform Discharges Using Deep Convolutional Neural Networks.

Int J Neural Syst 2019 Jan 8:1850060. Epub 2019 Jan 8.

§ Department of Computer and Communication, National Pingtung University, 51 Min Sheng East Road, Pingtung, 90003, Taiwan.

Numerous nonepileptic paroxysmal events, such as syncope and psychogenic nonepileptic seizures, may imitate seizures and impede diagnosis. Misdiagnosis can lead to mistreatment, affecting patients' lives considerably. Electroencephalography is commonly used for diagnosing epilepsy. Read More

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https://www.worldscientific.com/doi/abs/10.1142/S01290657185
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http://dx.doi.org/10.1142/S0129065718500600DOI Listing
January 2019
4 Reads

Can continual interictal epileptiform discharges cause persistent memory disturbances?

Psychogeriatrics 2019 Feb 18. Epub 2019 Feb 18.

Department of Psychiatry, Shinjuku Shinkei Clinic, Tokyo, Japan.

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http://dx.doi.org/10.1111/psyg.12429DOI Listing
February 2019

Epilepsy, depression, and growth hormone.

Epilepsy Behav 2019 Feb 14. Epub 2019 Feb 14.

Clinical and Translational Science Center, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, United States of America.

Depression affects a large proportion of patients with epilepsy, and is likely due in part to biological mechanism. Hormonal dysregulation due to the disruptive effects of seizures and interictal epileptiform discharges on the hypothalamic-pituitary-adrenal axis likely contributes to high rates of depression in epilepsy. This paper reviews the largely unexplored role of neuroendocrine factors in epilepsy-related depression, focusing on Growth Hormone (GH). Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.01.022DOI Listing
February 2019
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Assessing the localization accuracy and clinical utility of electric and magnetic source imaging in children with epilepsy.

Clin Neurophysiol 2019 Apr 31;130(4):491-504. Epub 2019 Jan 31.

Laboratory of Children's Brain Dynamics, Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Fetal-Neonatal Neuroimaging Developmental Science Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

Objective: To evaluate the accuracy and clinical utility of conventional 21-channel EEG (conv-EEG), 72-channel high-density EEG (HD-EEG) and 306-channel MEG in localizing interictal epileptiform discharges (IEDs).

Methods: Twenty-four children who underwent epilepsy surgery were studied. IEDs on conv-EEG, HD-EEG, MEG and intracranial EEG (iEEG) were localized using equivalent current dipoles and dynamical statistical parametric mapping (dSPM). Read More

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http://dx.doi.org/10.1016/j.clinph.2019.01.009DOI Listing
April 2019
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Quality of life and psychological dysfunction in traumatized and nontraumatized patients with psychogenic nonepileptic seizures (PNES).

Epilepsy Behav 2019 Mar 13;92:341-344. Epub 2019 Feb 13.

CAPHRI School for Public Health and Primary Care, Department of Health Services Research, Maastricht University, Maastricht, the Netherlands; Centre for Economic Evaluation, Trimbos Institute, Netherlands Institute of Mental Health and Addiction, Utrecht, the Netherlands.

Objectives: Psychogenic nonepileptic seizures (PNES) have the appearance of epileptic seizures, yet show no epileptiform discharges in the brain. The quality of life (QOL) in patients with PNES is reportedly low and trauma eems to be a relevant risk factor. The objective of this study was to examine the difference between measures of (epilepsy-specific) QOL (Quality of Life in Epilepsy Inventory; QOLIE-31p) and psychological dysfunction (trauma symptom inventory; TSI) between patients with diagnosed PNES with self-reported trauma and those without self-reported trauma. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15255050183095
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http://dx.doi.org/10.1016/j.yebeh.2019.01.024DOI Listing
March 2019
6 Reads
2.257 Impact Factor

Functional brain connectivity in electrical status epilepticus in sleep.

Epileptic Disord 2019 Feb;21(1):55-64

Department of Neurological Sciences, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.

Electrical status epilepticus in sleep (ESES) is an age-related, self-limited epileptic encephalopathy. The syndrome is characterized by cognitive and behavioral abnormalities and a specific EEG pattern of continuous spikes and waves during slow-wave sleep. While spikes and sharp waves are known to result in transient cognitive impairment during learning and memory tasks performed during the waking state, the effect of epileptiform discharges during sleep on cognition and behavior is unclear. Read More

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http://dx.doi.org/10.1684/epd.2019.1027DOI Listing
February 2019
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Source localization of epileptiform discharges in childhood absence epilepsy using a distributed source model: a standardized, low-resolution, brain electromagnetic tomography (sLORETA) study.

Neurol Sci 2019 May 12;40(5):993-1000. Epub 2019 Feb 12.

Department of Internal Medicine, Sanggye Paik Hospital, College of Medicine, Inje University, Seoul, Republic of Korea.

Localizing the source of epileptiform discharges in generalized epilepsy has been controversial for the past few decades. Recent neuroimaging studies have shown that epileptiform discharges in generalized epilepsy can be localized to a particular region. Childhood absence epilepsy (CAE) is the most common generalized epilepsy in childhood and is considered the prototype of idiopathic generalized epilepsy (IGE). Read More

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http://dx.doi.org/10.1007/s10072-019-03751-4DOI Listing
May 2019
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The Detection of the Negative Effects of Interictal Epileptiform Discharges on Cognition: An Event-Related Potential Study.

J Nerv Ment Dis 2019 Mar;207(3):209-216

Department of Neurology, Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, Jilin, People's Republic of China.

Evidence from a neuropsychological test revealed that interictal epileptiform discharges (IEDs) may have significant impact on cognitive performance. Sometimes, neuropsychological tests may not be sensitive to detection of mild cognitive changes. We applied P300 and mismatch negativity (MMN) to detect mild cognitive changes caused by small amount of IEDs. Read More

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http://dx.doi.org/10.1097/NMD.0000000000000945DOI Listing
March 2019
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Stridor as initial presentation of rolandic epilepsy.

Int J Pediatr Otorhinolaryngol 2019 Apr 30;119:183-184. Epub 2019 Jan 30.

Department of Otorhinolaryngology, Centro Hospitalar Vila Nova de Gaia/Espinho, Unidade 1, Serviço de Otorrinolaringologia, Pavilhão Feminino, Rua Conceição Fernandes, 4434-502, Vila Nova de Gaia, Portugal.

The authors present the case of a 5-year-old girl referred to our institution due to several episodes of nocturnal stridor with ocular retroversion and parental notion of apnea. She has been previously submitted to adenotonsillectomy. Due to symptoms worsening she was referred to our hospital. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01655876193005
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http://dx.doi.org/10.1016/j.ijporl.2019.01.040DOI Listing
April 2019
11 Reads

Inhibition and oscillations in the human brain tissue in vitro.

Neurobiol Dis 2019 May 8;125:198-210. Epub 2019 Feb 8.

Clinical Neurophysiology Department, Pitie-Salpetriere Hospital, Sorbonne Université, APHP, Paris 75013, France; Neuroglial Interactions in Cerebral Physiopathology, Center for Interdisciplinary Research in Biology, Collège de France, CNRS UMR 7241, INSERM U1050, Labex Memolife, PSL Research University, Paris 75005, France. Electronic address:

Oscillations represent basic operational modes of the human brain. They reflect local field potential activity generated by the laminar arrangement of cell-type specific microcircuits interacting brain-wide under the influence of neuromodulators, endogenous processes and cognitive demands. Under neuropathological conditions, the spatiotemporal structure of physiological brain oscillations is disrupted as recorded by electroencephalography and event-relate potentials. Read More

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http://dx.doi.org/10.1016/j.nbd.2019.02.006DOI Listing
May 2019
2 Reads

Delayed creatine supplementation counteracts reduction of GABAergic function and protects against seizures susceptibility after traumatic brain injury in rats.

Prog Neuropsychopharmacol Biol Psychiatry 2019 Feb 8;92:328-338. Epub 2019 Feb 8.

Programa de Pós-Graduação em Farmacologia, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil; Programa de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil; Laboratório de Bioquímica do Exercício, Programa de Pós-Graduação em Educação Física, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil. Electronic address:

Traumatic brain injury (TBI) is a devastating disease frequently followed by behavioral disabilities including post-traumatic epilepsy (PTE). Although reasonable progress in understanding its pathophysiology has been made, treatment of PTE is still limited. Several studies have shown the neuroprotective effect of creatine in different models of brain pathology, but its effects on PTE is not elucidated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02785846183081
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http://dx.doi.org/10.1016/j.pnpbp.2019.02.004DOI Listing
February 2019
6 Reads