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Seizure 2019 Mar;66:104-111

Epilepsy Center, The George Washington University School of Medicine and Health Sciences, Washington, DC, United States.

Purpose: We evaluate outcome of in-home diagnostic ambulatory video-EEG monitoring (AVEM) performed on a nationwide cohort of patients over one calendar year, and we compare our findings with outcomes of inpatient adult and pediatric VEM performed during the same year at two academic epilepsy centers.

Methods: This is a retrospective cohort study. We obtained AVEM outcome data from an independent ambulatory-EEG testing facility. Read More

Front Neurol 2019 5;10:64. Epub 2019 Feb 5.

Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.

Mutations in the Potassium channel subfamily T member 1 () gene have been reported in a range of epileptic encephalopathies. Here we report the case of a 12-year-old male suffering from multiple types of epileptic seizures and cognitive decline from the age of 10. The patient had four types of epileptic seizures, including tonic seizures, atypical absence seizures, myoclonic seizures, and generalized tonic-clonic seizures. Read More

PLoS Comput Biol 2019 02 25;15(2):e1006805. Epub 2019 Feb 25.

Aix Marseille Université, Inserm, Institut de Neurosciences des Systèmes, UMR_S 1106, 13005, Marseille, France.

Information transmission in the human brain is a fundamentally dynamic network process. In partial epilepsy, this process is perturbed and highly synchronous seizures originate in a local network, the so-called epileptogenic zone (EZ), before recruiting other close or distant brain regions. We studied patient-specific brain network models of 15 drug-resistant epilepsy patients with implanted stereotactic electroencephalography (SEEG) electrodes. Read More

BMC Neurol 2019 Feb 21;19(1):30. Epub 2019 Feb 21.

Department of Pediatrics, Chinese PLA General Hospital, Beijing, 100853, People's Republic of China.

Background: Posterior reversible encephalopathy syndrome (PRES) is a complication that occurs during various diseases' treatment. Imaging examination is the gold standard for diagnosis. PRES frequently occurrence in patients with hematological malignancies results in poorer prognosis and higher mortality. Read More

Int J Pediatr Otorhinolaryngol 2019 Apr 30;119:183-184. Epub 2019 Jan 30.

Department of Otorhinolaryngology, Centro Hospitalar Vila Nova de Gaia/Espinho, Unidade 1, Serviço de Otorrinolaringologia, Pavilhão Feminino, Rua Conceição Fernandes, 4434-502, Vila Nova de Gaia, Portugal.

The authors present the case of a 5-year-old girl referred to our institution due to several episodes of nocturnal stridor with ocular retroversion and parental notion of apnea. She has been previously submitted to adenotonsillectomy. Due to symptoms worsening she was referred to our hospital. Read More

Hum Genet 2019 Feb 17;138(2):187-198. Epub 2019 Jan 17.

Oasi Research Institute-IRCCS, Troina, Italy.

Developmental and epileptic encephalopathies (DEEs) are genetically heterogenous conditions, often characterized by early onset, EEG interictal epileptiform abnormalities, polymorphous and drug-resistant seizures, and neurodevelopmental impairments. In this study, we investigated the genetic defects in two siblings who presented with severe DEE, microcephaly, spastic tetraplegia, diffuse brain hypomyelination, cerebellar atrophy, short stature, and kyphoscoliosis. Whole exome next-generation sequencing (WES) identified in both siblings a homozygous non-sense variant in the ACTL6B gene (NM_016188:c. Read More

Seizure 2019 Feb 21;65:31-41. Epub 2018 Dec 21.

National Institute of Clinical Neuroscience, Budapest, Hungary.

We overview here the new data about the epileptic spectrum disorders within the frame of perisylvian epileptic network since our first trial to synthetize knowledge about this system epilepsy (Halász et al., 2005). We found evidences for a continual features relating together syndromes constituting this spectrum disorder in several fields: in sharing genetic origin, in common perisylvian human communication circuitry, in NREM sleep related potentiation of interictal epileptiform discharges of the centro-temporal spike phenomenon and in the discharge related cognitive impairment, reflecting functional deficits in human communication abilities. Read More

Afr Health Sci 2018 Sep;18(3):837-841

Department of Pediatrics, Vardhman Mahavir Medical College and Safdarjang Hospital.

Background: Although nodding syndrome is a catastrophic epileptic encephalopathy, it is reported only from Africa so far. We describe the first case from the Indian sub-continent.

Methods: A ten-year-old child who had an episode of Guillain Barre syndrome with incomplete recovery developed emaciation secondary to bulbar palsy and depression. Read More

Seizure 2019 Feb 19;65:20-24. Epub 2018 Dec 19.

University of Queensland, Brisbane, Australia; Neurology Department, Princess Alexandra Hospital, Brisbane, Australia.

Purpose: The clinical utility of EEG in cases of NMDA encephalitis is broad with many findings indicating not just epileptiform activity but also encephalopathy and potentially providing insights into pathophysiologic mechanisms of disease. We aimed to determine the frequency of different abnormalities described on EEG and their association with outcome in patients affected by NMDARE through a systematic review of all cases published.

Method: A systematic literature review of PubMed and Embase of all published cases of anti-NMDA receptor encephalitis with EEG results, was performed from inception to January 2018. Read More

Neurol Res 2019 Apr 24;41(4):298-305. Epub 2018 Dec 24.

b Department of Physiology, Faculty of Medicine , Tokat Gaziosmanpasa University , Tokat , Turkey.

Aim: Previous studies showed the existence of a relationship between epilepsy and depression. Duloxetine is a potent and selective inhibitor of serotonin and norepinephrine reuptake (SNRI) used in the treatment of the major depressive disorder. The aim of the present study was to investigate the effect of duloxetine on penicillin-induced epileptiform activity in an experimental rat model of acute partial epilepsy. Read More

Neurology 2018 Nov 9;91(22):e2078-e2088. Epub 2018 Nov 9.

From the Department of Clinical and Experimental Epilepsy (S.Z., Z.M., L.H.-H., S.K., S. Balestrini, S.M.S.) and Division of Neuropathology (Z.M., M.T.), UCL Institute of Neurology, London, UK; Clinic of Neurology (S.Z.), Department of Experimental and Clinical Medicine, Marche Polytechnic University, Ancona, Italy; Department of Pediatric Neurology and Neurological Rehabilitation (C.S., T.H., P.W., G.J.K.) and Neurosurgery Clinic and Clinic for Epilepsy Surgery (M.K.), Schön Klinik Vogtareuth; Department of Pediatrics (C.S., M.S.), Children's Hospital Augsburg, Germany; UCL Great Ormond Street Institute of Child Health (J.R.N., K.V., S.M.V., J.H.C.), London, UK; Paediatric Neurology and Neurogenetics Unit and Laboratories (D.M., R.G.), A. Meyer Children's Hospital, University of Florence, Italy; Chalfont Centre for Epilepsy (Z.M., L.H.-H., S.K., S. Balestrini, S.M.S.), Chalfont-St-Peter, Buckinghamshire, UK; CeGaT-Center for Genomics and Transcriptomics (A.P., S. Biskup), Tübingen, Germany; Neurogenetics Unit (M.L.), Department of Medical Genetics, Hospital de São João, Porto, Portugal; Department of Pediatrics and Adolescent Medicine (J.G.), University Medical Center Göttingen; Hospital for Children and Adolescents (A.M.), University Clinic Leipzig, Germany; Freiburg Medical Laboratory (M.J.), Dubai; The Danish Epilepsy Centre (R.S.M., E.G.), Dianalund; Institute for Regional Health Services (R.S.M., E.G.), University of Southern Denmark, Odense; Department of Clinical Genetics (B.S.K.), Odense University Hospital; Hans Christian Andersen Children's Hospital (L.K.H.), Odense, Denmark; Pediatric Neurology and Muscular Diseases Unit (M.S.V., P.S.), Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, and Maternal and Child Health, University of Genoa "G. Gaslini" Institute, Italy; Division of Neurology (K.L.H.), Children's Hospital of Philadelphia, PA; Department of Neurology (S.D., C.L.S.-H.), Division of Neurogenetics, Kennedy Krieger Institute, Baltimore, MD; Center for Genomic Medicine (N.H.-F.), Tohoku University; Department of Pediatrics (N.H.-F.), Tohoku University School of Medicine, Sendai, Japan; Department of Pediatrics (T.T., R.L.) and Institute of Clinical Medicine (K.O.), University of Tartu; Children's Clinic (T.T., R.L.), Department of Radiology (P.I.), and Department of Clinical Genetics, United Laboratories (K.O.), Tartu University Hospital, Estonia; Ludwig-Maximilians-University Munich (I.K.); Department of Pediatric Neurology (A.H.), Clinic Traunstein; Children's Hospital (M.K.), Dr. Horst Schmidt Klinik, Wiesbaden; Altona Children's Hospital (J.H.), Hamburg; Department of Pediatrics (C. Makowski), Technische Universität München, Germany; Department of Clinical Genetics (S.G.), Royal North Shore Hospital, St Leonards; John Hunter Children's Hospital (G.M.S.), New Lambton Heights, New South Wales, Australia; Department of Neurology (R.T.), University Hospital of Wales; Institute of Psychological Medicine and Clinical Neurosciences (R.H.T.), Cardiff University; Division of Neuroradiology (C. Micallef), National Hospital for Neurology and Neurosurgery, London; Department of Brain Repair & Rehabilitation (D.J.W.), Stroke Research Centre, UCL Institute of Neurology, London, UK; Paracelsus Medical University (G.J.K.), Salzburg, Austria; and IRCCS Stella Maris Foundation (R.G.), Pisa, Italy.

Objective: To characterize the neurologic phenotypes associated with mutations and to seek genotype-phenotype correlation.

Methods: We analyzed clinical, EEG, and neuroimaging data of 44 new and 55 previously reported patients with mutations.

Results: Childhood-onset focal seizures, frequently complicated by status epilepticus and resistance to antiepileptic drugs, was the most common phenotype. Read More

Cureus 2018 Aug 13;10(8):e3134. Epub 2018 Aug 13.

Internal Medicine, Punjab Medical College Allied Hospital Faisalabad, Faisalabad, PAK.

Lennox-Gastaut syndrome is one of the rare childhood-onset epileptic encephalopathies, characterized by multiple type seizure disorder, the typical pattern on electroencephalogram and intellectual disability. Tonic-type seizures are most commonly seen in these patients. Behavioral disturbances and cognitive decline are gradual-onset and last long after the first episode of epileptiform activity. Read More

Seizure 2018 Dec 26;63:48-51. Epub 2018 Oct 26.

Department of Neurology, University of Chicago, Chicago, IL 60637, USA.

Purpose: To determine the usefulness of the first-hour sleep EEG recording in identifying interictal epileptiform discharges (IEDs) during long-term video-EEG monitoring.

Method: We retrospectively reviewed 255 consecutive patients who underwent continuous long-term video-EEG monitoring in the adult epilepsy monitoring unit (EMU) at the University of Chicago. The complete video-EEG recording was reviewed, and the occurrence of IEDs was determined for each patient. Read More

Neurosci Biobehav Rev 2018 12 28;95:406-420. Epub 2018 Oct 28.

Montreal Neurological Institute and Departments of Neurology & Neurosurgery, and of Physiology, McGill University, 3801 University Street, Montréal, PQ, H3A 2B4, Canada; Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy. Electronic address:

Theta oscillations (4-12 Hz) represent one of the most prominent physiological oscillatory activity in the mammalian EEG. They are observed in several areas of the hippocampus and in parahippocampal structures. Theta oscillations play important roles in modulating synaptic plasticity during memory and learning; moreover, they are dependent on septal cholinergic inputs. Read More

Epileptic Disord 2018 Oct;20(5):413-417

Epilepsy Center, University Hospitals Cleveland Medical Centre, Cleveland, USA, Center for SUDEP Research.

STX1B is a gene that encodes syntaxin-1B. STX1B mutations have recently been implicated in fever-associated epilepsy syndromes. However, these have not previously been reported in sleep-related hypermotor epilepsy. Read More

Am J Hum Genet 2018 Nov 18;103(5):666-678. Epub 2018 Oct 18.

Division of Genetic Medicine, University of Washington, Seattle, WA 98195, USA. Electronic address:

Developmental and epileptic encephalopathies (DEEs) are severe neurodevelopmental disorders often beginning in infancy or early childhood that are characterized by intractable seizures, abundant epileptiform activity on EEG, and developmental impairment or regression. CACNA1E is highly expressed in the central nervous system and encodes the α-subunit of the voltage-gated Ca2.3 channel, which conducts high voltage-activated R-type calcium currents that initiate synaptic transmission. Read More

PLoS One 2018 19;13(10):e0206095. Epub 2018 Oct 19.

Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Objectives: To investigate the long-term postoperative outcomes and predictive factors associated with poor surgical outcomes in mesial temporal lobe epilepsy (MTLE).

Materials And Methods: We enrolled patients with MTLE who underwent resective surgery at single university-affiliated hospital. Surgical outcomes were determined using a modified Engel classification at the 2nd and 5th years after surgery and the last time of follow-up. Read More

Epilepsia 2018 11 19;59(11):2019-2034. Epub 2018 Oct 19.

Neuroscience Institute, Morehouse School of Medicine, Atlanta, Georgia.

Objective: To determine when spontaneous granule cell epileptiform discharges first occur after hippocampal injury, and to identify the postinjury "latent" period as either a "silent" gestational state of epileptogenesis or a subtle epileptic state in gradual transition to a more obvious epileptic state.

Methods: Nonconvulsive status epilepticus evoked by perforant path stimulation in urethane-sedated rats produced selective and extensive hippocampal injury and a "latent" period that preceded the onset of the first clinically obvious epileptic seizures. Continuous granule cell layer depth recording and video monitoring assessed the time course of granule cell hyperexcitability and the onset/offset times of spontaneous epileptiform discharges and behavioral seizures. Read More

Epilepsia 2018 11 17;59(11):2035-2048. Epub 2018 Oct 17.

Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah.

Objective: Approximately 30% of patients with epilepsy are refractory to existing antiseizure drugs (ASDs). Given that the properties of the central nervous systems of these patients are likely to be altered due to their epilepsy, tissues from rodents that have undergone epileptogenesis might provide a therapeutically relevant disease substrate for identifying compounds capable of attenuating pharmacoresistant seizures. To facilitate the development of such a model, this study describes the effects of classical glutamate receptor antagonists and 20 ASDs on recurrent epileptiform discharges (REDs) in brain slices derived from the kainate-induced status epilepticus model of temporal lobe epilepsy (KA-rats). Read More

J Clin Neurosci 2018 Dec 13;58:201-203. Epub 2018 Oct 13.

Epilepsy Center, Department of Neurology, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, United States.

Ictal gaze deviation and oculogyric crisis (OGC) can show identical clinical manifestations. We report a case of repeated drug induced OGCs in a 38 year old patient with secondary progressive multiple sclerosis. He was referred to our center for treatment of "intractable" epilepsy manifesting as episodic eye and head deviations with apparent unresponsiveness. Read More

J Vet Intern Med 2018 Nov 16;32(6):2037-2044. Epub 2018 Oct 16.

Department of Internal Medicine and Clinic for Horses, Dogs and Cats, The Faculty of Veterinary Medicine, Wrocław University of Environmental and Life Sciences, Wrocław, Poland.

Background: In humans, temporal lobe epilepsy (TLE), is a type of focal epilepsy occurring mainly in the mesial TLE (mTLE), commonly associated with hippocampal sclerosis (HS).

Objectives: According to recent studies, TLE might also occur in dogs and could be associated with hippocampal atrophy (HA)/HS. To date, hippocampal lesions have not been correlated with electroencephalographic (EEG) findings in epileptic dogs. Read More

J Craniofac Surg 2018 Nov;29(8):2195-2197

Department of Plastic, Reconstructive and Aesthetic Surgery and Hacettepe Cleft and Craniofacial Center.

Accompanying neurologic disorders directly affect psychosocial development of cleft lip and/or cleft palate (CLP) patients and make it difficult for their family to look after them properly. The aim of this study was to investigate the diversity and the incidence of additional neurologic malformations in children with CLP and to evaluate their effects on cleft care. All patients who applied to our Cleft and Craniofacial Center between July 2014 and July 2017 were included in the study. Read More

J Neurosci Rural Pract 2018 Oct-Dec;9(4):478-486

Department of Medicine, University of Cartagena, Cartagena de Indias, Colombia.

Background And Objectives: Statins are inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, used for the management of hypercholesterolemia and related atherosclerotic diseases. Several studies have indicated the neuroprotective effects of statins on several neuropathological conditions. However, the role of these medications in epilepsy is still unclear. Read More

Epilepsy Behav 2018 10 28;87:173-179. Epub 2018 Sep 28.

Epilepsy Center, Department of Neurology, University Hospital Erlangen, Erlangen, Germany.

Introduction: Afterdischarges (ADs) are a common and unwanted byproduct of direct cortical stimulation during invasive electroencephalography (EEG) recordings. Brief pulse stimulation (BPS) can sometimes terminate ADs. This study investigated AD characteristics and their relevance for emergence of stimulation seizures. Read More

Drug Des Devel Ther 2018 11;12:2945-2958. Epub 2018 Sep 11.

Department of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China,

Background: Chronic temporal lobe epilepsy (cTLE) is the most common intractable epilepsy. Recent studies have shown that saikosaponin A (SSa) could inhibit epileptiform discharges induced by 4 action potentials and selectively increase the transient inactivating K currents (). However, the mechanisms of SSa on remain unclear. Read More

Proc Natl Acad Sci U S A 2018 10 17;115(40):10166-10171. Epub 2018 Sep 17.

Department of Neuroscience, Physiology and Pharmacology, University College London, London, WC1E 6BT, United Kingdom;

The type 2 K/Cl cotransporter (KCC2) allows neurons to maintain low intracellular levels of Cl, a prerequisite for efficient synaptic inhibition. Reductions in KCC2 activity are evident in epilepsy; however, whether these deficits directly contribute to the underlying pathophysiology remains controversial. To address this issue, we created knock-in mice in which threonines 906 and 1007 within KCC2 have been mutated to alanines (KCC2-T906A/T1007A), which prevents its phospho-dependent inactivation. Read More

Neuroimage Clin 2018 5;20:674-684. Epub 2018 Sep 5.

Department of Medical Physics and Biomedical Engineering, University College London, UK.

Electrical Impedance Tomography (EIT) is an emerging medical imaging technique which can produce tomographic images of internal impedance changes within an object using non-penetrating surface electrodes. It has previously been used to image impedance changes due to neuronal depolarisation during evoked potentials in the rat somatosensory cortex with a resolution of 2 ms and <200 μm, using an epicortical electrode array. The purpose of this work was to use this technique to elucidate the intracortical spatiotemporal trajectory of ictal spike-and-wave discharges (SWDs), induced by electrical stimulation in an acute rat model of epilepsy, throughout the cerebral cortex. Read More

Seizure 2018 Oct 27;61:214-220. Epub 2018 Aug 27.

Department of Neurology, Oslo University Hospital - Rikshospitalet, PO Box 4950 Nydalen, 0424 Oslo, Norway; Faculty of Medicine, University of Oslo, PO Box 1072 Blindern, 0316 Oslo, Norway. Electronic address:

Purpose: The congenital long QT-syndrome (cLQTS) is characterized by ventricular arrhythmias, syncope and sudden cardiac death. Many LQTS genes are also expressed in the brain and emerging evidence suggest that cardiac channelopathies can also cause epilepsy. The aim of the study is to explore evidence of epilepsy and/or EEG abnormalities in a cohort with a genotyped diagnosis of LQT1 or LQT2. Read More

Medicina (B Aires) 2018;78 Suppl 2:18-24

Cátedra de Neuropediatría, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.

A febrile seizure occurs in association with fever in a child aged 6 to 60 months, without central nervous system infection or other known cause of acute seizures in a child without a prior history of afebrile seizures. Febrile seizures occur in about 2-5% of children. Central nervous system infections should be considered in patients with febrile seizures, even though the frequency of this possibility is low, especially when patients do not return to baseline. Read More

Medicina (B Aires) 2018;78 Suppl 2:6-11

Unidad de Epilepsia, Sección de Neuropediatría, Hospital Infantil Universitario Niño Jesús, Madrid, España. E-mail:

Paroxysmal episodes are one of the most common neurological disorders in children. It is important to distinguish between paroxysmal non-epileptic events, symptomatic seizures, febrile seizures, and unprovoked seizures. Patient's history is the key to proper diagnosis in most of the cases. Read More

BMC Neurosci 2018 09 5;19(1):51. Epub 2018 Sep 5.

Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Cra 24 No 63C-69, Bogotá, Colombia.

Adipose tissue is a dynamic organ with different effects on the body. Many of these effects are mediated by leptin, a hormone strongly involved in regulation of feeding and energy metabolism. It has an important role as a mediator of neuronal excitatory activity and higher brain functions. Read More

Zhonghua Er Ke Za Zhi 2018 Sep;56(9):667-673

Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.

To summarize the clinical features of TBC1D24 gene mutations associated with epilepsy. All the patients with TBC1D24 gene compound heterozygous mutations were retrospectively collected at the Pediatric Department of Peking University First Hospital from March 2015 to July 2017, and the features of clinical manifestations, electroencephalogram, and neuroimaging were analyzed. Eighteen cases with TBC1D24 gene compound heterozygous mutations were included. Read More

Epilepsia 2018 10 26;59(10):1919-1930. Epub 2018 Aug 26.

INSERM, UMR1249, INMED, Aix-Marseille University, Marseille, France.

Objective: The epilepsy-aphasia spectrum (EAS) is a heterogeneous group of age-dependent childhood disorders characterized by sleep-activated discharges associated with infrequent seizures and language, cognitive, and behavioral deficits. Defects in the GRIN2A gene, encoding a subunit of glutamate-gated N-methyl-d-aspartate (NMDA) receptors, represent the most important cause of EAS identified so far. Neocortical or thalamic lesions were detected in a subset of severe EAS disorders, and more subtle anomalies were reported in patients with so-called "benign" phenotypes. Read More

Neurosci Bull 2018 Dec 20;34(6):1007-1016. Epub 2018 Aug 20.

Department of Neurology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.

Exploring the transition from inter-ictal to ictal epileptiform discharges (IDs) and how GABA receptor-mediated action affects the onset of IDs will enrich our understanding of epileptogenesis and epilepsy treatment. We used Mg-free artificial cerebrospinal fluid (ACSF) to induce epileptiform discharges in juvenile mouse hippocampal slices and used a micro-electrode array to record the discharges. After the slices were exposed to Mg-free ACSF for 10 min-20 min, synchronous recurrent seizure-like events were recorded across the slices, and each event evolved from inter-ictal epileptiform discharges (IIDs) to pre-ictal epileptiform discharges (PIDs), and then to IDs. Read More

Zhongguo Dang Dai Er Ke Za Zhi 2018 Aug;20(8):652-657

Department of Neurology, Affiliated Children's Hospital of Capital Institute of Pediatrics, Beijing 100020, China.

Supernumerary marker chromosome 15 is a rare chromosome abnormality. This paper reports the clinical diagnosis and treatment, as well as genetic defects, of a child with supernumerary marker chromosome 15. The patient was a 9. Read More

BMC Neurol 2018 Aug 13;18(1):110. Epub 2018 Aug 13.

Department of Neurosurgery, Xuan Wu Hospital, Capital Medical University, No 45, Changchun Street, Xicheng District, Beijing, 100053, China.

Background: Seizures arising from the precuneus are rare, and few studies have aimed at characterizing the clinical presentation of such seizures within the anatomic context of the frontoparietal circuits. We aimed to characterize the electrophysiological properties and clinical features of seizures arising from the precuneus based on data from stereoelectroencephalography (SEEG).

Methods: The present retrospective study included 10 patients with medically intractable epilepsy, all of whom were diagnosed with precuneal epilepsy via stereoelectroencephalography (SEEG) at Yuquan Hospital and Xuan Wu Hospital between 2014 and 2016. Read More

Epilepsy Behav 2018 10 8;87:152-158. Epub 2018 Aug 8.

Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Camperdown, Australia; ARC Centre of Excellence in Cognition and Its Disorders, Sydney Medical School, The University of Sydney, Sydney, Australia.

Disturbed sleep can negatively affect overnight memory retention as well as new learning the subsequent day. In healthy participants, positive associations between memory performance and sleep characteristics (e.g. Read More

Neurol Sci 2018 Nov 9;39(11):1977-1980. Epub 2018 Aug 9.

Department of Pediatrics, Division of Child Neurology, Ege University Faculty of Medicine, Bornova, 35100, Izmir, Turkey.

Epileptic encephalopathies are a group of disorders in which epileptiform abnormalities cause progressive deterioration in cerebral function. Genetic causes have been described in several of the epileptic encephalopathies, and many previously unknown genes have been identified. WW domain-containing oxidoreductase (WWOX) has recently been implicated in autosomal recessive spinocerebellar ataxia type 12 (SCAR12) and severe early-onset epileptic encephalopathy. Read More

Pharmacol Rep 2018 Oct 14;70(5):885-889. Epub 2018 Mar 14.

Department of Biology, Faculty of Science, Erciyes University, Kayseri, Turkey. Electronic address:

Background: The most common headache associated with epilepsy occurs after seizure activity and is called a postictal headache. Therefore, the objective of this study was to investigate the effects of low and high doses acetylsalicylic acid (aspirin) on a penicillin-induced experimental epilepsy model.

Methods: Adult male Wistar rats (n = 28, weighing 220 ± 40 g) were used in the experiments. Read More

Med Sci Monit 2018 Aug 4;24:5405-5411. Epub 2018 Aug 4.

Division of Pediatric Neurology, Department of Pediatrics, University Hospital Centre Zagreb, Zagreb, Croatia.

BACKGROUND The aim of this study was to assess sleep architecture and respiration during sleep in children with intractable epileptic encephalopathies using overnight video-polysomnography (V-PSG). MATERIAL AND METHODS Between 2015 to 2017 overnight V-PSG recordings were made for 31 children (22 boys and 9 girls) with intractable epileptic encephalopathy with a mean age of 6.78±3. Read More

Res Rep Trop Med 2018 24;9:89-93. Epub 2018 May 24.

Department of Pediatrics and Child Health, College of Health Sciences, Makerere University, Kampala, Uganda.

Nodding syndrome is an enigmatic neuropsychiatric and epileptiform disorder associated with psychomotor, mental, and physical growth retardation. The disorder affects otherwise previously normal children aged 3-18 years, with a slight preponderance for the male child. Nodding syndrome has been described in rural regions of some low-income countries in sub-Saharan Africa including northern Uganda, South Sudan, and a mountainous region of southern Tanzania. Read More

Physiol Meas 2018 08 20;39(8):085003. Epub 2018 Aug 20.

Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom.

Objective: Electrical impedance tomography (EIT) can be used to image impedance changes associated with epileptiform activity and so holds therapeutic potential for improving presurgical localisation of the ictal onset zone in patients with treatment-resistant epilepsy. There are two principal impedance changes which occur during seizures that may be imaged with EIT: (a) a fast, transient impedance decrease over milliseconds due to hypersynchronous neuronal depolarisation in individual ictal discharges; and (b) a larger, slow impedance increase caused by cell swelling over the course of the seizure. The magnitude of these signals is highly dependent on the carrier frequency of applied current used for obtaining impedance measurements. Read More

Epilepsy Behav 2018 09 19;86:157-162. Epub 2018 Jul 19.

"La Sapienza" University, Department of Pediatrics, Child Neurology Division, Italy. Electronic address:

Introduction: Rolandic epilepsy, also known as benign childhood epilepsy with centrotemporal spikes (BECTS), is one of the most common epileptic syndromes in previously healthy children. Despite what was known about the benignity of this syndrome, there is always more evidence about the involvement of the cognitive functions with different deficits in several domains to be investigated.

Aim Of The Study: The aim of our study was to describe prognostic electroencephalogram (EEG) pattern of an adverse cognitive development to recognize patients at higher risk of lasting cognitive deficits that could need antiepileptic drugs (AEDs) or an improved neurocognitive therapy. Read More

Seizure 2018 Aug 28;60:198-204. Epub 2018 Jun 28.

Mellen Center for Multiple Sclerosis, Cleveland Clinic Foundation, Cleveland, OH, USA.

Purpose: We sought to characterize the electroclinical features of seizures associated with autoimmune encephalitis and their relevance to outcome.

Methods: 19 patients with seizures and autoimmune encephalitis were identified from a database of 100 patients (2008-2017) with autoimmune neurological disorders. Clinical and electroclinical characteristics were collected. Read More

J Clin Neurophysiol 2018 Sep;35(5):375-380

School of Computing, Clemson University, Clemson, South Carolina, U.S.A.

Objective: The goal of the study was to measure the performance of academic and private practice (PP) neurologists in detecting interictal epileptiform discharges in routine scalp EEG recordings.

Methods: Thirty-five EEG scorers (EEGers) participated (19 academic and 16 PP) and marked the location of ETs in 200 30-second EEG segments using a web-based EEG annotation system. All participants provided board certification status, years of Epilepsy Fellowship Training (EFT), and years in practice. Read More

Epilepsia 2018 08 15;59(8):1577-1582. Epub 2018 Jul 15.

Epilepsy Center, Department of Neurology, University Hospital, Ludwig-Maximilians-University, Munich, Germany.

Objective: To evaluate the necessity of recording ictal electroencephalography (EEG) in patients with temporal lobe epilepsy (TLE) considered for resective surgery who have unilateral temporal interictal epileptiform discharges (IEDs) and concordant ipsitemporal magnetic resonance imaging (MRI) pathology. To calculate the necessary number of recorded EEG seizure patterns (ESPs) to achieve adequate lateralization probability.

Methods: In a retrospective analysis, the localization and lateralization of interictal and ictal EEG of 304 patients with lesional TLE were analyzed. Read More

Epilepsy Res 2018 09 28;145:145-152. Epub 2018 Jun 28.

Center for Global Health - Tumbes, Universidad Peruana Cayetano Heredia, Lima, Peru; Cysticercosis Unit, Department of Transmissible Diseases, Instituto Nacional de Ciencias Neurologicas, Lima, Peru; Department of Microbiology, School of Sciences, Universidad Peruana Cayetano Heredia, Lima, Peru.

Objective: Discordances between imaging findings of parenchymal neurocysticercosis and seizure expression have been reported, and as such the possibility that neurocysticercosis and seizures may frequently coexist by chance has been raised. In this study, we evaluate the topographic relationship between seizure foci based on semiology and electroencephalography with the location of parenchymal neurocysticercotic lesions.

Methods: Seizure information, neuroimaging (computed tomography and magnetic resonance imaging [MRI]) and electroencephalographic data from three randomized clinical trials of individuals with parenchymal neurocysticercosis and focal seizures were analyzed. Read More

J Clin Neurophysiol 2018 Nov;35(6):454-462

Pediatric Epilepsy Unit, Division of Child and Adolescent Neurology, Children's Memorial Hermann Hospital, Houston, Texas, U.S.A.

Purpose: Magnetoencephalography (MEG) is often incorporated into the presurgical work-up of children with pharmacoresistant epilepsy. There is growing literature on its role in improving selection for epilepsy surgery, particularly when brain MRI is "non-lesional" or in patients with recurrence or intractable seizures after epilepsy surgery. There are, however, no reports on the extrapolation of its role in the presurgical decision-making process of infants. Read More

J Neuroinflammation 2018 Jul 11;15(1):203. Epub 2018 Jul 11.

Instituto de Farmacologia e Neurociências, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.

Background: Epilepsy is a prevalent neurological disorder worldwide. It is characterized by an enduring predisposition to generate seizures and its development is accompanied by alterations in many cellular processes. Organotypic slice cultures represent a multicellular environment with the potential to assess biological mechanisms, and they are used as a starting point for refining molecules for in vivo studies. Read More

Seizure 2018 Aug 28;60:139-143. Epub 2018 Jun 28.

Department of Neurology, GIPMER, New Delhi, India.

Purpose: To study modulation of epileptiform EEG discharges in patients with JME.

Method: 50 subjects with JME underwent a sleep deprived EEG recording along with conventional provocative methods and testing with cognitive tasks (CTs). Both categories of tests were evaluated for their effect on occurrence of IEDs. Read More