988 results match your criteria Epilepsy Sudden Unexpected Death in


National registry for sudden unexpected deaths of infants and children in England: why do we need one and do families want one?

Arch Dis Child 2019 Apr 20. Epub 2019 Apr 20.

Child and Adolescent Health, University of Bristol, Bristol, UK.

The sudden and unexpected death of an infant or child is devastating. An inability to explain why an infant or child died is difficult to accept for both families and professionals. No reliable national dataset exists to estimate precisely how many infants and children die unexpectedly each year in England. Read More

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http://dx.doi.org/10.1136/archdischild-2018-316542DOI Listing
April 2019
1 Read

Delayed maturation of GABAergic signaling in the Scn1a and Scn1b mouse models of Dravet Syndrome.

Sci Rep 2019 Apr 17;9(1):6210. Epub 2019 Apr 17.

Department of Pharmacology, University of Michigan, Ann Arbor, MI, 48109-5632, USA.

Dravet syndrome (DS) is a catastrophic developmental and epileptic encephalopathy characterized by severe, pharmacoresistant seizures and the highest risk of Sudden Unexpected Death in Epilepsy (SUDEP) of all epilepsy syndromes. Here, we investigated the time course of maturation of neuronal GABAergic signaling in the Scn1b and Scn1a mouse models of DS. We found that GABAergic signaling remains immature in both DS models, with a depolarized reversal potential for GABA-evoked currents compared to wildtype in the third postnatal week. Read More

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http://www.nature.com/articles/s41598-019-42191-0
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http://dx.doi.org/10.1038/s41598-019-42191-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470170PMC
April 2019
3 Reads

Time of Day and a Ketogenic Diet Influence Susceptibility to SUDEP in Mice.

Front Neurol 2019 29;10:278. Epub 2019 Mar 29.

Department of Neurology, University of Iowa, Iowa City, IA, United States.

Sudden unexpected death in epilepsy (SUDEP) is a major cause of mortality in patients with drug-resistant epilepsy. Most SUDEP cases occur in bed at night and are preceded by a generalized tonic-clonic seizure (GTCS). Dravet syndrome (DS) is a severe childhood-onset epilepsy commonly caused by mutations in the gene. Read More

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https://www.frontiersin.org/article/10.3389/fneur.2019.00278
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http://dx.doi.org/10.3389/fneur.2019.00278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449461PMC
March 2019
2 Reads

Cardiorespiratory profiling reveals primary breathing dysfunction in Kcna1-null mice: Implications for sudden unexpected death in epilepsy.

Neurobiol Dis 2019 Apr 8;127:502-511. Epub 2019 Apr 8.

Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences Center Shreveport, LA 71103, USA. Electronic address:

Sudden unexpected death in epilepsy (SUDEP) is the leading cause of epilepsy-related mortality, but the relative importance of underlying cardiac and respiratory mechanisms remains unclear. To illuminate the interactions between seizures, respiration, cardiac function, and sleep that contribute to SUDEP risk, here we developed a mouse epilepsy monitoring unit (EMU) to simultaneously record video, electroencephalography (EEG), electromyography (EMG), plethysmography, and electrocardiography (ECG) in a commonly used genetic model of SUDEP, the Kcna1 knockout (Kcna1) mouse. During interictal periods, Kcna1 mice exhibited an abnormal absence of post-sigh apneas and a 3-fold increase in respiratory variability. Read More

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http://dx.doi.org/10.1016/j.nbd.2019.04.006DOI Listing
April 2019
2 Reads

Music-Enhanced Analgesia and Antiseizure Activities in Animal Models of Pain and Epilepsy: Toward Preclinical Studies Supporting Development of Digital Therapeutics and Their Combinations With Pharmaceutical Drugs.

Front Neurol 2019 27;10:277. Epub 2019 Mar 27.

Department of Medicinal Chemistry, University of Utah, Salt Lake, UT, United States.

Digital therapeutics (software as a medical device) and mobile health (mHealth) technologies offer a means to deliver behavioral, psychosocial, disease self-management and music-based interventions to improve therapy outcomes for chronic diseases, including pain and epilepsy. To explore new translational opportunities in developing digital therapeutics for neurological disorders, and their integration with pharmacotherapies, we examined analgesic and antiseizure effects of specific musical compositions in mouse models of pain and epilepsy. The music playlist was created based on the modular progression of Mozart compositions for which reduction of seizures and epileptiform discharges were previously reported in people with epilepsy. Read More

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http://dx.doi.org/10.3389/fneur.2019.00277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446215PMC
March 2019
1 Read

[Postictal pulmonary oedema: a review of the literature].

Rev Neurol 2019 Apr;68(8):339-345

Pontificia Universidad Javeriana, Bogota DC, Colombia.

Introduction: Postictal neurogenic pulmonary oedema is an infrequent condition of varying severity, probably related to sudden unexpected death in epilepsy (SUDEP). It is more frequent in patients with generalised tonic-clonic seizures of long duration or with status epilepticus.

Aim: Based on a review of the literature, the aim is to describe the clinical characteristics, pathophysiology, radiological findings, treatment and prognosis of patients with postictal pulmonary oedema. Read More

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http://dx.doi.org/10.33588/rn.6808.2018356DOI Listing

Time, frequency and information domain analysis of short-term heart rate variability before and after focal and generalized seizures in epileptic children.

Physiol Meas 2019 Apr 5. Epub 2019 Apr 5.

TMO "Psychiatry", Kyiv, Ukraine, UKRAINE.

Objective: In this work we explore the potential of combining standard time and frequency domain indexes with novel information measures, to characterize pre- and post-ictal heart rate variability (HRV) in epileptic children, with the aim of differentiating focal and generalized epilepsy regarding the autonomic control mechanisms. Approach: We analyze short-term HRV in 37 children suffering from generalized or focal epilepsy, monitored 10s, 300s, 600s and 1800s both before and after seizure episodes. Nine indexes are computed in time (mean, standard deviation of normal-to-normal intervals, root mean square of the successive differences(RMSSD)), frequency (low-to-high frequency power ratio LF/HF, normalized LF and HF power) and information (entropy, conditional entropy and self-entropy) domains. Read More

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http://dx.doi.org/10.1088/1361-6579/ab16a3DOI Listing
April 2019
1 Read

The effect of seizure spread to the amygdala on respiration and onset of ictal central apnea.

J Neurosurg 2019 04 5:1-11. Epub 2019 Apr 5.

Departments of Neurology and

Objective: Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death for patients with refractory epilepsy, and there is increasing evidence for a centrally mediated respiratory depression as a pathophysiological mechanism. The brain regions responsible for a seizure’s inducing respiratory depression are unclear—the respiratory nuclei in the brainstem are thought to be involved, but involvement of forebrain structures is not yet understood. The aim of this study was to analyze intracranial EEGs in combination with the results of respiratory monitoring to investigate the relationship between seizure spread to specific mesial temporal brain regions and the onset of respiratory dysfunction and apnea. Read More

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https://thejns.org/view/journals/j-neurosurg/aop/article-10.
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http://dx.doi.org/10.3171/2019.1.JNS183157DOI Listing
April 2019
7 Reads

Interictal electrocardiographic alternations in patients with drug-resistant epilepsy.

Seizure 2018 Jul 9;69:7-10. Epub 2018 Jul 9.

Cardiopulmonary Research Center, Shaheed Beheshti University of Medical Science, Tehran, Iran.

Purpose: Previous studies suggested the possible role of autonomic dysfunction in sudden unexpected death in epilepsy (SUDEP). The aim of this study is to assess the interictal ECG alternations especially heart rate variability (HRV), as a marker of autonomic dysfunction, in patients with drug-resistant epilepsy and determine the effect of epilepsy type and duration, seizure frequency and anti-epileptic drugs (AEDs) on ECG findings.

Methods: In this comparative cross-sectional study, the interictal ECG parameters of 64 consecutive patients with drug-resistant epilepsy and the same number of age and sex-matched controls were analyzed. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.07.002DOI Listing
July 2018
2 Reads

Long-term outcome in neurostimulation of epilepsy.

Epilepsy Behav 2019 Feb 30;91:25-29. Epub 2018 Jun 30.

Epilepsy Center, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Germany. Electronic address:

For patients with pharmacoresistant focal epilepsy, neurostimulation offers nonpharmacological strategies to improve seizure control. Vagus nerve stimulation (VNS), deep brain stimulation of the anterior thalamic nuclei, and responsive neurostimulation (RNS) are approved therapies which have shown efficacy in randomized short-term trials. Controlled data from prospective studies are needed to confirm reports on stable or even increasing evidence from studies with longer follow-up and to confirm that neurostimulation may offer advantages also regarding cognitive tolerability and sudden unexpected death in epilepsy (SUDEP)-risk. Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.06.011DOI Listing
February 2019
1 Read

Impaired CO-Induced Arousal in SIDS and SUDEP.

Trends Neurosci 2019 Apr;42(4):242-250

Department of Neurology and Iowa Neuroscience Institute, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA. Electronic address:

Premature, sudden death is devastating. Certain patient populations are at greater risk to succumb to sudden death. For instance, infants under 1year of age are at risk for sudden infant death syndrome (SIDS), and patients with epilepsy are at risk for sudden unexpected death in epilepsy (SUDEP). Read More

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http://dx.doi.org/10.1016/j.tins.2019.02.002DOI Listing
April 2019
1 Read

A case of sudden unexpected death of a patient with epilepsy: Continuous electrocardiographic monitoring and autopsy results.

HeartRhythm Case Rep 2019 Mar 30;5(3):138-142. Epub 2018 Nov 30.

Cardiac Arrhythmia Department, National Medical Research Center for Preventive Medicine, Moscow, Russia.

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http://dx.doi.org/10.1016/j.hrcr.2018.11.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404162PMC
March 2019
1 Read

Neuroimaging of Sudden Unexpected Death in Epilepsy (SUDEP): Insights From Structural and Resting-State Functional MRI Studies.

Front Neurol 2019 5;10:185. Epub 2019 Mar 5.

Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, United Kingdom.

The elusive nature of sudden unexpected death in epilepsy (SUDEP) has led to investigations of mechanisms and identification of biomarkers of this fatal scenario that constitutes the leading cause of premature death in epilepsy. In this short review, we compile evidence from structural and functional neuroimaging that demonstrates alterations to brain structures and networks involved in central autonomic and respiratory control in SUDEP and those at elevated risk. These findings suggest that compromised central control of vital regulatory processes may contribute to SUDEP. Read More

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http://dx.doi.org/10.3389/fneur.2019.00185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413533PMC

Incidence, Recurrence, and Risk Factors for Peri-ictal Central Apnea and Sudden Unexpected Death in Epilepsy.

Front Neurol 2019 1;10:166. Epub 2019 Mar 1.

Department of Neurology, University of Texas Health Science Center at Houston, Houston, TX, United States.

Peri-ictal breathing dysfunction was proposed as a potential mechanism for SUDEP. We examined the incidence and risk factors for both ictal (ICA) and post-convulsive central apnea (PCCA) and their relationship with potential seizure severity biomarkers (i. e. Read More

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http://dx.doi.org/10.3389/fneur.2019.00166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413671PMC
March 2019
1 Read

Control of the cardiovascular and respiratory systems during sleep.

Auton Neurosci 2019 May 30;218:54-63. Epub 2019 Jan 30.

Department of Neurology, Mayo Clinic, Rochester, MN, United States of America. Electronic address:

Sleep and arousal from sleep are associated with profound changes in cardiovascular and respiratory functions. Fluctuations of arterial blood pressure (ABP), heart rate (HR), and respiration occur both during non-rapid eye movement (NREM) and REM sleep and during transitions between sleep and behavioral arousal. These changes reflect complex, state-dependent interactions among several neuronal groups in the hypothalamus and brainstem. Read More

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http://dx.doi.org/10.1016/j.autneu.2019.01.007DOI Listing
May 2019
2 Reads

Chemoreflex failure and sleep-disordered breathing in familial dysautonomia: Implications for sudden death during sleep.

Auton Neurosci 2019 May 15;218:10-15. Epub 2019 Feb 15.

Department of Neurology, Dysautonomia Center, New York University School of Medicine, New York, NY, United States of America. Electronic address:

Familial dysautonomia (Riley-Day syndrome, hereditary sensory and autonomic neuropathy type III) is a rare autosomal recessive disease characterized by impaired development of primary sensory and autonomic neurons resulting in a severe neurological phenotype, which includes arterial baroreflex and chemoreflex failure with high frequency of sleep-disordered breathing and sudden death during sleep. Although a rare disease, familial dysautonomia represents a unique template to study the interactions between sleep-disordered breathing and abnormal chemo- and baroreflex function. In patients with familial dysautonomia, ventilatory responses to hypercapnia are reduced, and to hypoxia are almost absent. Read More

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http://dx.doi.org/10.1016/j.autneu.2019.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428199PMC
May 2019
2 Reads

Sudden Unexpected Death and the Mammalian Dive Response: Catastrophic Failure of a Complex Tightly Coupled System.

Authors:
Frank F Vincenzi

Front Physiol 2019 19;10:97. Epub 2019 Feb 19.

Department of Pharmacology, University of Washington, Seattle, WA, United States.

In tightly coupled complex systems, when two or more factors or events interact in unanticipated ways, catastrophic failures of high-risk technical systems happen rarely, but quickly. Safety features are commonly built into complex systems to avoid disasters but are often part of the problem. The human body may be considered as a complex tightly coupled system at risk of rare catastrophic failure (sudden unexpected death, SUD) when certain factors or events interact. Read More

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https://www.frontiersin.org/article/10.3389/fphys.2019.00097
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http://dx.doi.org/10.3389/fphys.2019.00097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389676PMC
February 2019
3 Reads

Qualitative insights into the feelings, knowledge, and impact of SUDEP: A narrative synthesis.

Epilepsy Behav 2019 Mar 15;94:20-28. Epub 2019 Mar 15.

Bournemouth University, Faculty of Health and Social Sciences, Royal London House, Christchurch Rd., Bournemouth BH1 3LT, England, United Kingdom of Great Britain and Northern Ireland.

People with epilepsy (PWE) have a two- to threefold increased chance of premature death due to the condition. Interested in exploring the first-person perspective on this topic, we conducted a narrative synthesis to present the qualitative insight of PWE, their family, friends, and healthcare providers (HCPs) in relation to epilepsy-related death. A comprehensive electronic search of all peer-reviewed qualitative studies was conducted through databases using relevant keywords and Medical Subject Headings (MeSH) terms. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.02.015DOI Listing

Cerebellar, limbic, and midbrain volume alterations in sudden unexpected death in epilepsy.

Epilepsia 2019 Apr 14;60(4):718-729. Epub 2019 Mar 14.

Department of Clinical and Experimental Epilepsy, University College London Institute of Neurology, London, UK.

Objective: The processes underlying sudden unexpected death in epilepsy (SUDEP) remain elusive, but centrally mediated cardiovascular or respiratory collapse is suspected. Volume changes in brain areas mediating recovery from extreme cardiorespiratory challenges may indicate failure mechanisms and allow prospective identification of SUDEP risk.

Methods: We retrospectively imaged SUDEP cases (n = 25), patients comparable for age, sex, epilepsy syndrome, localization, and disease duration who were high-risk (n = 25) or low-risk (n = 23), and age- and sex-matched healthy controls (n = 25) with identical high-resolution T1-weighted scans. Read More

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http://dx.doi.org/10.1111/epi.14689DOI Listing
April 2019
5 Reads
4.571 Impact Factor

Exome sequencing identifies molecular diagnosis in children with drug-resistant epilepsy.

Epilepsia Open 2019 Mar 6;4(1):63-72. Epub 2018 Dec 6.

Department of Paediatrics & Adolescent Medicine LKS Faculty of Medicine The University of Hong Kong Hong Kong SAR China.

Objective: Early onset drug-resistant epilepsy is a neurologic disorder in which 2 antiepileptic drugs fail to maintain the seizure-free status of the patient. Heterogeneous clinical presentations make the diagnosis challenging. We aim to identify the underlying genetic causes of a pediatric cohort with drug-resistant epilepsy and evaluate whether the findings can provide information on patient management. Read More

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http://dx.doi.org/10.1002/epi4.12282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398105PMC
March 2019
4 Reads

Multimodal wrist-worn devices for seizure detection and advancing research: Focus on the Empatica wristbands.

Epilepsy Res 2019 Feb 27. Epub 2019 Feb 27.

Empatica, Milan, Italy; Empatica, Cambridge, MA, USA; MIT Media Lab, Massachusetts Institute of Technology, Cambridge, MA, USA.

Wearable automated seizure detection devices offer a high potential to improve seizure management, through continuous ambulatory monitoring, accurate seizure counts, and real-time alerts for prompt intervention. More importantly, these devices can be a life-saving help for people with a higher risk of sudden unexpected death in epilepsy (SUDEP), especially in case of generalized tonic-clonic seizures (GTCS). The Embrace and E4 wristbands (Empatica) are the first commercially available multimodal wristbands that were designed to sense the physiological hallmarks of ongoing GTCS: while Embrace only embeds a machine learning-based detection algorithm, both E4 and Embrace devices are equipped with motion (accelerometers, ACC) and electrodermal activity (EDA) sensors and both the devices received medical clearance (E4 from EU CE, Embrace from EU CE and US FDA). Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.02.007DOI Listing
February 2019
6 Reads

Are Seizure Detection Devices Ready for Prime Time?

Authors:
Paul C Van Ness

Epilepsy Curr 2019 Jan 15;19(1):36-37. Epub 2019 Feb 15.

Standards for testing and clinical validation of seizure detection Beniczky S, Ryvlin P. Epilepsia. 2018;59(S1):9-13. Read More

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http://dx.doi.org/10.1177/1535759719827430DOI Listing
January 2019
4 Reads

The Insula and Its Epilepsies.

Epilepsy Curr 2019 Jan 31;19(1):11-21. Epub 2019 Jan 31.

8 Northwell Health, Great Neck, NY, USA.

Insular seizures are great mimickers of seizures originating elsewhere in the brain. The insula is a highly connected brain structure. Seizures may only become clinically evident after ictal activity propagates out of the insula with semiology that reflects the propagation pattern. Read More

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http://dx.doi.org/10.1177/1535759718822847DOI Listing
January 2019
5 Reads

Risk Factors for Sudden Unexpected Death in Epilepsy (SUDEP) and Their Mitigation.

Curr Treat Options Neurol 2019 Feb 13;21(2). Epub 2019 Feb 13.

Division of Neurology, Department of Paediatrics, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada.

Purpose Of Review: People with epilepsy have an increased risk of mortality when compared to the general population. Sudden unexpected death in epilepsy (SUDEP) is the most common cause of epilepsy-related death in children and adults. The purpose of this review is to discuss SUDEP, with an emphasis on SUDEP risk factors, their mitigation and prevention. Read More

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http://link.springer.com/10.1007/s11940-019-0547-4
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http://dx.doi.org/10.1007/s11940-019-0547-4DOI Listing
February 2019
4 Reads

Ventilatory response to CO in patients with epilepsy.

Epilepsia 2019 Mar 12;60(3):508-517. Epub 2019 Feb 12.

Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, Iowa.

Objective: Severe periictal respiratory depression is thought to be linked to risk of sudden unexpected death in epilepsy (SUDEP) but its determinants are largely unknown. Interindividual differences in the interictal ventilatory response to CO (hypercapnic ventilatory response [HCVR] or central respiratory CO chemosensitivity) may identify patients who are at increased risk for severe periictal hypoventilation. HCVR has not been studied previously in patients with epilepsy; therefore we evaluated a method to measure it at bedside in an epilepsy monitoring unit (EMU) and examined its relationship to postictal hypercapnia following generalized convulsive seizures (GCSs). Read More

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http://dx.doi.org/10.1111/epi.14660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401234PMC
March 2019
3 Reads

Parental perspectives on provider adherence to AAN epilepsy quality measures in rural and urban tertiary care centers.

Epilepsy Behav 2019 Mar 4;92:256-259. Epub 2019 Feb 4.

Children's National Health System, Center for Neuroscience, 111 Michigan Avenue NW, Washington, DC 10010, USA. Electronic address:

Several American Academy of Neurology (AAN) epilepsy practice guidelines recommend conversations that neurologists should have with patients and their parents. We sought to determine whether parents of pediatric patients with epilepsy had knowledge of epilepsy quality measures (EQMs) and whether they recalled having discussions with their child's neurologist about each of the EQM. Surveys were distributed to parents at five clinic sites associated with epilepsy centers in Washington, DC and Charlottesville, Virginia. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.01.009DOI Listing
March 2019
2 Reads

Effect of monoamine reuptake inhibition and α blockade on respiratory arrest and death following electroshock-induced seizures in mice.

Epilepsia 2019 Mar 5;60(3):495-507. Epub 2019 Feb 5.

The Iowa Neuroscience Institute, University of Iowa, Iowa City, Iowa.

Objective: Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in patients with refractory epilepsy. Although the mechanisms for SUDEP are incompletely understood, seizure-induced respiratory arrest (S-IRA) has been strongly and consistently implicated. A body of evidence indicates that serotonin (5-HT), a modulator of breathing, plays a critical role in SUDEP. Read More

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http://dx.doi.org/10.1111/epi.14652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467066PMC

Fenfluramine, a serotonin-releasing drug, prevents seizure-induced respiratory arrest and is anticonvulsant in the DBA/1 mouse model of SUDEP.

Epilepsia 2019 Mar 4;60(3):485-494. Epub 2019 Feb 4.

Departments of Pharmacology and Neurology, Southern Illinois University School of Medicine, Springfield, Illinois.

Objective: Prevention of sudden unexpected death in epilepsy (SUDEP) is a critical goal for epilepsy therapy. The DBA/1 mouse model of SUDEP exhibits an elevated susceptibility to seizure-induced death in response to electroconvulsive shock, hyperthermia, convulsant drug, and acoustic stimulation. The serotonin hypothesis of SUDEP is based on findings that treatments which modify serotonergic function significantly alter susceptibility to seizure-induced sudden death in several epilepsy models, including DBA/1 mice. Read More

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http://dx.doi.org/10.1111/epi.14658DOI Listing
March 2019
3 Reads

Epilepsy and Sleep-Related Breathing Disturbances.

Chest 2019 Jan 31. Epub 2019 Jan 31.

Cleveland Clinic Sleep Disorders Center, Cleveland, OH. Electronic address:

Epilepsy is the fourth most common neurologic disorde in the United States, affecting over 2.2 million people. Epilepsy is associated with a number of medical and psychiatric comorbidities, higher health-care use and cost, and substantial economic burden. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00123692193006
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http://dx.doi.org/10.1016/j.chest.2019.01.016DOI Listing
January 2019
9 Reads

Are there mortality risks for patients with epilepsy who use cannabis treatments as monotherapy?

Epilepsy Behav Case Rep 2019 3;11:52-53. Epub 2018 Dec 3.

Swedish Epilepsy Center, 550 17th Ave suite 540, Seattle, WA 98122, USA.

Mortality associated with cannabis used for treatment of epilepsy is not well documented. We discuss two fatalities in the setting of epilepsy and self-determined therapy with cannabis (SDTC). One patient had probable sudden unexpected death in epilepsy, the second death was due to seizure-associated drowning. Read More

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http://dx.doi.org/10.1016/j.ebcr.2018.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348695PMC
December 2018
2 Reads

Risks and predictive biomarkers of sudden unexpected death in epilepsy patient.

Curr Opin Neurol 2019 Apr;32(2):205-212

NINDS Center for SUDEP Research and Texas Comprehensive Epilepsy Center, University of Texas Houston Health Sciences Center, Houston, Texas, USA.

Purpose Of Review: The current review updates our knowledge regarding sudden unexpected death in epilepsy patient (SUDEP) risks, risk factors, and investigations of putative biomarkers based on suspected mechanisms of SUDEP.

Recent Findings: The overall incidence of SUDEP in adults with epilepsy is 1.2/1000 patient-years, with surprisingly comparable figures in children in recently published population-based studies. Read More

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http://Insights.ovid.com/crossref?an=00019052-201904000-0000
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http://dx.doi.org/10.1097/WCO.0000000000000668DOI Listing
April 2019
3 Reads

Ictal asystole with isolated syncope: A case report and literature review.

Epilepsy Behav Case Rep 2019 24;11:47-51. Epub 2018 Nov 24.

Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE 68198-8435, USA.

Ictal syncope is a rare phenomenon that occurs in association with 0.002-0.4% of seizures. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22133232183014
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http://dx.doi.org/10.1016/j.ebcr.2018.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327908PMC
November 2018
12 Reads

Fifty years' follow-up of childhood epilepsy: Medical outcome, morbidity, and medication.

Epilepsia 2019 Mar 20;60(3):381-392. Epub 2019 Jan 20.

Faculty of Medicine and Health, Department of Pediatrics, Örebro University, Örebro, Sweden.

Objective: To describe the long-term prognosis of childhood epilepsy, with special emphasis on seizure remission, relapse, medication, associated neurologic impairment, mortality rate, and cause of death.

Methods: A prospective longitudinal study on a population-based total cohort of 195 children with epileptic seizures in 1962-1964. Data were collected from medical records and a questionnaire. Read More

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http://dx.doi.org/10.1111/epi.14643DOI Listing
March 2019
17 Reads
4.571 Impact Factor

Sudden unexpected death in epilepsy: Rethinking the unthinkable.

Epilepsy Behav 2019 Jan 17. Epub 2019 Jan 17.

Krankenanstalt Rudolfstiftung, Vienna, Messerli Institute, Veterinary University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1016/j.yebeh.2019.01.002DOI Listing
January 2019
1 Read

Sudden unexpected death in GEFS+ families with sodium channel pathogenic variants.

Epilepsy Res 2019 02 14;150:66-69. Epub 2019 Jan 14.

Research Institute of the McGill University Health Center, 2155 Guy Street, Montreal, PQ, H3H 2L9, Canada; Department of Pediatrics, Division of Child Neurology, Montreal Children's Hospital, McGill University Health Centre, 1001 Boulevard Décarie, Montreal, PQ, H4A 3J1, Canada.

We aimed to describe families with genetic epilepsy with febrile seizures plus (GEFS+) in which individuals suffered sudden unexpected death. The Epilepsy Pharmacogenomics Research Database was reviewed for GEFS + families in which at least one individual had suffered sudden death, and two families were identified. In Family A, five males had febrile seizures and one girl had febrile seizures plus. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.01.009DOI Listing
February 2019
5 Reads

Effects of enalapril and losartan alone and in combination with sodium valproate on seizures, memory, and cardiac changes in rats.

Epilepsy Behav 2019 Mar 16;92:345-352. Epub 2019 Jan 16.

Translational Health Science and Technology Institute, Faridabad, Haryana, India.

Purpose: Cardiac changes accompanying seizures may be responsible for sudden unexpected death in epilepsy (SUDEP), and drugs with antiseizure and favorable cardiovascular profile could be beneficial. The effect of losartan and enalapril alone and in combination with sodium valproate on seizures, cognition, cardiac histopathology, and serum brain-derived neurotropic factor (BDNF) levels were determined.

Methods: Male "Wistar" rats (200-250 g) were administered enalapril (20 mg/kg, intraperitoneally (i. Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.12.019DOI Listing
March 2019
3 Reads

Brainstem spreading depolarization and cortical dynamics during fatal seizures in Cacna1a S218L mice.

Brain 2019 Feb;142(2):412-425

Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.

Sudden unexpected death in epilepsy (SUDEP) is a fatal complication of epilepsy in which brainstem spreading depolarization may play a pivotal role, as suggested by animal studies. However, patiotemporal details of spreading depolarization occurring in relation to fatal seizures have not been investigated. In addition, little is known about behavioural and neurophysiological features that may discriminate spontaneous fatal from non-fatal seizures. Read More

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http://dx.doi.org/10.1093/brain/awy325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351775PMC
February 2019
2 Reads

How can transition to adult care be best orchestrated for adolescents with epilepsy?

Epilepsy Behav 2019 Jan 11. Epub 2019 Jan 11.

Department of Pediatric Neurology, Hôpital Necker Enfants Malades, Université Paris Descartes, Institut Imagine (INSERM UMR 1163), Paris, France.

Objective evidence is limited for the value of transition programs for youth with chronic illness moving from pediatric to adult care; however, such programs intuitively "make sense". We describe the strengths and weaknesses of a variety of transition programs from around the world for adolescents with epilepsy. Consequences of poorly organized transition beyond suboptimal seizure control may include an increased risk of sudden unexpected death in epilepsy (SUDEP), poor psychological and social outcome, and inadequate management of comorbidities. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15255050183102
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http://dx.doi.org/10.1016/j.yebeh.2018.12.015DOI Listing
January 2019
30 Reads

Limbic and paralimbic structures driving ictal central apnea.

Neurology 2019 Feb 11;92(7):e655-e669. Epub 2019 Jan 11.

From the Epilepsy Center (N.L., J.P.H., J.P.M., S.L.), University Hospitals Cleveland Medical Center, OH; Department of Neurobiology and the Brain Research Institute (R.M.H.), University of California, Los Angeles; and NINDS Center for SUDEP Research (R.M.H., S.L.), Case Western Reserve University, Cleveland, OH.

Objective: To precisely identify cortical regions that modulate breathing, and delineate a network of cortical structures that underpin ictal central apnea (ICA) during epileptic seizures.

Methods: We electrically stimulated multiple cortical structures in patients undergoing stereotactic EEG (SEEG) evaluation before epilepsy surgery. Structures investigated were orbitofrontal cortex, anterior and posterior cingulate and subcallosal gyri, insula, hippocampus, parahippocampal gyrus, amygdala, temporo-polar cortex, antero-mesial fusiform gyrus, and lateral and basal temporal cortices. Read More

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http://dx.doi.org/10.1212/WNL.0000000000006920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382368PMC
February 2019
1 Read

Tonic electromyographic activity following bilateral tonic-clonic seizures is associated with periictal respiratory dysfunction and postictal generalized EEG suppression.

Epilepsia 2019 Feb 10;60(2):268-274. Epub 2019 Jan 10.

Department of Neurology, University of California Davis, Davis, California.

Objective: No biomarkers reliably predict risk for sudden unexpected death in epilepsy (SUDEP). Postictal generalized electroencephalography (EEG) suppression (PGES) is a possible biomarker for SUDEP risk. However, its utility in predicting SUDEP remains uncertain. Read More

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http://dx.doi.org/10.1111/epi.14632DOI Listing
February 2019
3 Reads

Dead in the Night: Sleep-Wake and Time-Of-Day Influences on Sudden Unexpected Death in Epilepsy.

Front Neurol 2018 11;9:1079. Epub 2018 Dec 11.

Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, IA, United States.

Sudden unexpected death in epilepsy (SUDEP) is the leading cause of epilepsy-related death in patients with refractory epilepsy. Convergent lines of evidence suggest that SUDEP occurs due to seizure induced perturbation of respiratory, cardiac, and electrocerebral function as well as potential predisposing factors. It is consistently observed that SUDEP happens more during the night and the early hours of the morning. Read More

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http://dx.doi.org/10.3389/fneur.2018.01079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297781PMC
December 2018

Impact of repeated kindled seizures on heart rate rhythms, heart rate variability, and locomotor activity in rats.

Epilepsy Behav 2019 Mar 3;92:36-44. Epub 2019 Jan 3.

Institute of Pharmacology, Toxicology and Pharmacy, Ludwig-Maximilians-University (LMU), Munich, Germany. Electronic address:

Although an impact of epilepsy on circadian rhythmicity is well-recognized, there are profound gaps in our understanding of the influence of seizures on diurnal rhythms. The effect on activity levels and heart rate is of particular interest as it might contribute to the disease burden. The kindling model with telemetric transmitter implants provides excellent opportunities to study the consequences of focal and generalized seizures under standardized conditions. Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.11.034DOI Listing

Decreasing SUDEP incidence in a tertiary epilepsy center between 1981 and 2016: Effects of better patient supervision.

Epilepsy Behav 2019 Mar 21;92:1-4. Epub 2018 Dec 21.

Gesellschaft für Epilepsieforschung, Maraweg 21, D-33617 Bielefeld, Germany. Electronic address:

Objective: The objective of this study was to investigate the incidence of sudden unexpected death in epilepsy (SUDEP) in a tertiary epilepsy center in the years 1981-2016 with an emphasis on patient supervision and nursing intervention in different departments.

Methods: We identified 14 SUDEP cases (probable, definite, definite plus). Patient-years (PY) and incidence were calculated for the periods of six years for the general epileptology wards (adults and children) and, in addition, for the epilepsy monitoring unit (EMU) since 1990. Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.11.019DOI Listing

Postconvulsive central apnea and asystole: A risk marker for sudden unexpected death in epilepsy (SUDEP)?

Neurology 2019 Jan 19;92(3):115-116. Epub 2018 Dec 19.

From the Mayo Center for Sleep Medicine (E.K.S.L.); Departments of Neurology (E.K.S.L.) and Medicine (E.K.S.L.), Mayo Clinic and Foundation, Rochester, MN; and Department of Neurology (B.A.D.), Brigham and Women's Hospital, Boston, MA.

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http://dx.doi.org/10.1212/WNL.0000000000006765DOI Listing
January 2019
1 Read

Postconvulsive central apnea as a biomarker for sudden unexpected death in epilepsy (SUDEP).

Neurology 2019 Jan 19;92(3):e171-e182. Epub 2018 Dec 19.

From the NINDS Center for SUDEP Research (L.V., M.R.S.R., R.K.S., D.F., M.N., C.S., B.K.G., B.Z., A.Z., S.S., J.O., R.M.H., B.D., L.B., O.D., G.B.R., P.R., S.D.L.); Epilepsy Center (L.V., N.L., J.P.H., N.J.H., N.S., X.Z., V.R.-M., S.D.L.) and Division of Pulmonary, Critical Care and Sleep Medicine (K.S.), University Hospitals Cleveland Medical Center, OH; University of Iowa School of Medicine (R.K.S., B.K.G., G.B.R.), Iowa City; NYU Langone School of Medicine (D.F., O.D.), New York; Sidney Kimmel Medical College (M.N.), Thomas Jefferson University, Philadelphia, PA; Institute of Neurology (C.S., B.D.), University College London, UK; Feinberg School of Medicine (S.S.), Northwestern University, Chicago, IL; Department of Neurobiology and Brain Research Institute (J.O., R.M.H.), University of California, Los Angeles (UCLA); Department of Neurology (L.B.), Columbia University, New York, NY; and Department of Clinical Neuroscience (P.R.), Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.

Objective: To characterize peri-ictal apnea and postictal asystole in generalized convulsive seizures (GCS) of intractable epilepsy.

Methods: This was a prospective, multicenter epilepsy monitoring study of autonomic and breathing biomarkers of sudden unexpected death in epilepsy (SUDEP) in patients ≥18 years old with intractable epilepsy and monitored GCS. Video-EEG, thoracoabdominal excursions, nasal airflow, capillary oxygen saturation, and ECG were analyzed. Read More

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http://dx.doi.org/10.1212/WNL.0000000000006785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340388PMC
January 2019
18 Reads

Sudden unexpected death in epilepsy: The neuro-cardio-respiratory connection.

Seizure 2019 Jan 13;64:65-73. Epub 2018 Dec 13.

Athens University School of Medicine, Athens, Greece. Electronic address:

Sudden unexpected death in epilepsy (SUDEP) is the major cause of epilepsy-related premature mortality which targets preferentially younger people. Its etiology remains unknown. Several risk factors have been identified with generalized tonic-clonic seizures as the most important one; seizure control remains the most effective measure of prevention. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.12.007DOI Listing
January 2019
4 Reads

Sudden unexpected death with rare compound heterozygous variants in PRICKLE1.

Neurogenetics 2019 Mar 18;20(1):39-43. Epub 2018 Dec 18.

Department of Legal Medicine, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.

Progressive myoclonus epilepsy-ataxia syndrome (EPM5) is an autosomal recessive form of progressive myoclonus epilepsy that has been associated with a homozygous missense mutation in PRICKLE1. We report a 23-year-old male who died shortly after refractory convulsion and respiratory failure. Autopsy showed unilateral hippocampal malformation without significant neuronal loss or gliosis. Read More

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http://dx.doi.org/10.1007/s10048-018-0562-8DOI Listing
March 2019
1 Read

Late-onset Lennox-Gastaut syndrome: Diagnostic evaluation and outcome.

Neurol Clin Pract 2018 Oct;8(5):397-402

Department of Neurology, Mayo Clinic, Rochester, MN.

Background: We describe the clinical features and outcome in patients with late-onset Lennox-Gastaut syndrome (LGS).

Methods: Adult patients evaluated between January 1, 2000, and March 1, 2017, who presented with onset of LGS ≥10 years were identified. Data abstracted included age at seizure onset, seizure types, etiology, treatments, EEG and neuroimaging results, cerebrospinal fluid (CSF) findings, and autoimmune evaluation. Read More

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http://dx.doi.org/10.1212/CPJ.0000000000000527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276343PMC
October 2018
2 Reads

The effect of generalized seizure activity on ischemia-induced cardiac arrhythmias and myocardial injury with histopathological evaluation in anesthetized rats

Turk J Med Sci 2018 Dec 12;48(6):1293-1301. Epub 2018 Dec 12.

Department of Physiology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey

Background/aim: Epileptic seizure leads to sudden unexpected death in epilepsy (SUDEP) among affected patients. The causes of SUDEP are still unclear. The aim of this study was to research the effect of epilepsy on myocardial injury and arrhythmias during experimentally induced acute myocardial ischemia. Read More

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http://dx.doi.org/10.3906/sag-1807-99DOI Listing
December 2018