4,591 results match your criteria Epilepsy Research[Journal]


Seizure control by low-intensity ultrasound in mice with temporal lobe epilepsy.

Epilepsy Res 2019 Apr 4;154:1-7. Epub 2019 Apr 4.

State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, 100875, China. Electronic address:

Background: Temporal lobe epilepsy (TLE) is the most common form of focal epilepsy. Recent studies have demonstrated that ultrasound stimulation can inhibit spontaneous recurrent seizures and improve behavioral outcomes for rodents with TLE. However, the exact underlying mechanism for inhibition of TLE via ultrasound stimulation remains unknown. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.04.002DOI Listing

Long-term safety and efficacy following conversion to eslicarbazepine acetate monotherapy in adults with focal seizures.

Epilepsy Res 2019 Mar 29;153:59-65. Epub 2019 Mar 29.

Sunovion Pharmaceuticals Inc., 84 Waterford Drive, Marlborough, MA, 01752, USA.

Objective: To assess the long-term safety and efficacy of eslicarbazepine acetate (ESL) monotherapy in adults with focal seizures (FS).

Methods: Study 050 was a long-term, multicenter, open-label (OL) safety extension of two conversion-to-ESL monotherapy studies in adults with refractory FS. After participating in Study 045 or 046, patients started on ESL 1600 mg once daily (QD) (or 1200 mg if they previously had a dose reduction), and could adjust the dose 400 mg/week to a dose between 800-2400 mg QD. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.03.018DOI Listing
March 2019
1 Read

HCN ion channels and accessory proteins in epilepsy: genetic analysis of a large cohort of patients and review of the literature.

Epilepsy Res 2019 Apr 8;153:49-58. Epub 2019 Apr 8.

Unit of Genetics of Neurodegenerative and Metabolic Diseases, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.

The Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) channels are highly expressed in the Central Nervous Systems, where they are responsible for the I current. Together with specific accessory proteins, these channels finely regulate neuronal excitability and discharge activity. In the last few years, a substantial body of evidence has been gathered showing that modifications of I can play an important role in the pathogenesis of epilepsy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09201211193015
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http://dx.doi.org/10.1016/j.eplepsyres.2019.04.004DOI Listing
April 2019
1 Read

Harmonization of pipeline for detection of HFOs in a rat model of post-traumatic epilepsy in preclinical multicenter study on post-traumatic epileptogenesis.

Epilepsy Res 2019 Mar 15. Epub 2019 Mar 15.

Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

Studies of chronic epilepsy show pathological high frequency oscillations (HFOs) are associated with brain areas capable of generating epileptic seizures. Only a few of these studies have focused on HFOs during the development of epilepsy, but results suggest pathological HFOs could be a biomarker of epileptogenesis. The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy" (EpiBioS4Rx) is a multi-center project designed to identify biomarkers of epileptogenesis after a traumatic brain injury (TBI) and evaluate treatments that could modify or prevent the development of post-traumatic epilepsy. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.03.008DOI Listing
March 2019
2 Reads

Efficacy and safety of Levetiracetam as adjunctive treatment in children with focal onset seizures: A systematic review and meta-analysis.

Epilepsy Res 2019 Apr 3;153:40-48. Epub 2019 Apr 3.

College of Pharmacy, Jinan University, Guangzhou, 510632, China; Institute of Dongguan-Jinan University, Dongguan, 523808, China; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), Jinan University, Guangzhou, 510632, China. Electronic address:

Objective: To assess the efficacy and safety of levetiracetam (LEV) as adjunctive treatment in children (0-18 years) with focal-onset seizures (FOS) with a larger dataset.

Methods: A pooled analysis would be performed for prospective clinical trials and a meta-analysis for controlled studies. Retrospectives studies were also summarized using descriptive statistics. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.04.001DOI Listing
April 2019
1 Read

Infection with HHV-6 and its role in epilepsy.

Epilepsy Res 2019 Mar 29;153:34-39. Epub 2019 Mar 29.

Center for Neuroscience, Children's National Medical Center, George Washington University, 111 Michigan Ave NW, Washington, DC 20010, USA.

Infection with Human Herpesvirus-6 (HHV-6) has been associated with different epilepsy syndromes, including febrile seizures and status epilepticus, acute symptomatic seizures secondary to encephalitis and temporal lobe epilepsy. This neurotropic DNA virus is ubiquitous and primary infection occurs in up to 80% of children by age two years. While two viral variants have been identified, HHV-6B is the one that has been primarily linked to disease in humans, including epilepsy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09201211183062
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http://dx.doi.org/10.1016/j.eplepsyres.2019.03.016DOI Listing
March 2019
3 Reads

Technology-enabled seizure detection and reporting: The epilepsy network project.

Authors:
Rupert A Page

Epilepsy Res 2019 Feb 26. Epub 2019 Feb 26.

Poole Hospital NHS Foundation Trust, Poole Hospital, Poole, BH15 2JB, UK.

The traditional models of epilepsy care provision have not changed substantially in more than a century, despite rapid advances in computing, technology and materials science. One consequence of these advances has been the near universal prevalence of smartphones. Wearable devices with a complex sensor arrays are an emerging technology. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.02.016DOI Listing
February 2019
2 Reads

Lessons learned from transcutaneous vagus nerve stimulation (tVNS).

Epilepsy Res 2019 Feb 26. Epub 2019 Feb 26.

Epilepsy Center Frankfurt Rhine-Main, Dept. of Neurology, University of Frankfurt, Germany. Electronic address:

Transcutaneous vagus nerve stimulation (tVNS) is a newly developed method which intends to overcome the disadvantage of surgical implantation of the stimulation device. The tVNS device is designed to stimulate the auricular branch of the vagus nerve via a bipolar electrode attached to the skin of the left ear conch. A randomized, double-blind controlled trial assessed efficacy and safety over 20 weeks of tVNS (n=39) vs. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.02.015DOI Listing
February 2019
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Childhood-only epilepsy with generalized tonic-clonic seizures: A well-defined epileptic syndrome.

Epilepsy Res 2019 Mar 27;153:28-33. Epub 2019 Mar 27.

Department of Neurology, Hospital de Pediatría "Prof. Dr. Juan P. Garrahan", Buenos Aires, Argentina.

Purpose: The aim of this study was to analyze patients whose only manifestation of epilepsy were generalized tonic-clonic seizures (GTCS) during childhood and discuss its validity as separate syndrome of childhood.

Methods: We included children with at least two unprovoked GTCS between 3 and 11 years of age, no other seizure types at diagnosis, normal psychomotor development and neurological examination, an EEG with normal background and paroxysms of generalized spikes and waves with a frequency 2.5 Hz or above, and an unknown cause for epilepsy. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.03.017DOI Listing
March 2019
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Chronic prostatitis/chronic pelvic pain syndrome increases susceptibility to seizures in rats and alters brain levels of IL-1β and IL-6.

Epilepsy Res 2019 Mar 22;153:19-27. Epub 2019 Mar 22.

Laboratory of Neurophysiology, Institute of Medical Physiology "Richard Burian", Belgrade University Faculty of Medicine, Belgrade, Serbia. Electronic address:

Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) is a result of interplay between psychological, immune, neurological and genetic factors, manifested by variety of urological, as well as brain-related symptoms. However, its relation with brain excitability has not been addressed. herefore, our aim was to assess susceptibility to seizures in rats with CP/CPPS. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.03.014DOI Listing
March 2019
5 Reads

Effects of sinapic acid on hepatic cytochrome P450 3A2, 2C11, and intestinal P-glycoprotein on the pharmacokinetics of oral carbamazepine in rats: Potential food/herb-drug interaction.

Epilepsy Res 2019 Mar 22;153:14-18. Epub 2019 Mar 22.

Quality Assurance Unit, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.

Dietary supplements, herbal medicines, and other foods may affect the pharmacokinetics and/or pharmacodynamics of carbamazepine (CBZ), which may possibly lead to potential drug-drug/herb-drug interactions, as CBZ has a narrow therapeutic window. Sinapic acid (SA) is a bioactive phytoconstituent used as a dietary supplement for the treatment of epilepsy. This study determined the effects of SA on the pharmacokinetics of CBZ and proposed a possible interaction mechanism in twenty-four male wistar rats (180-210 g). Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.03.012DOI Listing
March 2019
2.015 Impact Factor

Effects of levetiracetam and valproic acid treatment on liver function tests, plasma free carnitine and lipid peroxidation in childhood epilepsies.

Epilepsy Res 2019 Mar 15;153:7-13. Epub 2019 Mar 15.

Ankara University Faculty of Medicine, Department of Pediatric Metabolism Cebeci Mahallesi, Cebeci Yerleşkesi, 06590 Çankaya, Mamak, Ankara, Turkey. Electronic address:

Background And Aims: The relationship between anti-epileptic usage and oxidative damage has not yet been clearly understood. In our study, we investigated oxidative stress parameters, carnitine levels, liver function tests (LFT) and their relationship in epileptic children treated with valproic acid or levetiracetam.

Method: LFTs, serum free carnitine and oxidative damage markers and their relations with each other were determined in patients who are on valproic acid or levetiracetam treatment at least for 6 months. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.03.009DOI Listing

Targeting analysis of a novel parietal approach for deep brain stimulation of the anterior nucleus of the thalamus for epilepsy.

Epilepsy Res 2019 Mar 19;153:1-6. Epub 2019 Mar 19.

Department of Neurosurgery, Mayo Clinic, Rochester, MN, USA. Electronic address:

Purpose: Deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) is a promising treatment for refractory epilepsy; however, it remains challenging to successfully target the ANT. The results of Medtronic Registry for Epilepsy (MORE) supported a frontal transventricular(TV) compared to frontal extraventricular (EV) lead trajectory for ANT DBS may have better coverage of the ANT. Here we report the safety and targeting efficacy of a novel, posterior parietal extraventricular (PEV) approach to the ANT. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.03.010DOI Listing
March 2019
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Transition from status epilepticus to interictal spiking in a rodent model of mesial temporal epilepsy.

Epilepsy Res 2019 05 11;152:73-76. Epub 2019 Mar 11.

Montreal Neurological Institute and Departments of Neurology & Neurosurgery, and of Physiology, McGill University, 3801 University Street, Montréal, H3A 2B4, QC, Canada. Electronic address:

Status epilepticus (SE) is a serious, life-threatening condition requiring immediate care to prevent neuronal injury and long-term functional deficits. SE is modeled in rodents by systemic injection of chemoconvulsants such as pilocarpine, which induces EEG and behavioral activities similar to what seen in humans. Combined injection of diazepam and ketamine is commonly used to terminate SE in rodents but, to date, no study has analysed the EEG activity and behavior during SE and after diazepam + ketamine administration. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.03.005DOI Listing
May 2019
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A summary of data presented at the XIV conference on new antiepileptic drug and devices (EILAT XIV).

Epilepsy Res 2019 Mar 11. Epub 2019 Mar 11.

Department of Pharmacy, School of Pharmacy, University of Washington, Seattle, WA, USA.

The Fourteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIV) took place in Madrid, Spain from May 13th to 16th 2018. Again, presentations on new medical devices and neuromodulation and discussions on device-related regulatory aspects were included in the programme. The virtual special issue on "neuromodulation" summarises the presentations focusing firstly, on the pre-clinical developments and the difficulties of clinical trial designs for neuromodulatory therapies, including vagus nerve stimulation (VNS) and Brain-Responsive Neurostimulation (RNS), and the use of transcutaneous vagus nerve stimulation (tVNS) as a potential screening tool for determining the efficacy of neuromodulatory treatments in individual patients; secondly, on wearable devices for seizure monitoring through indices of peripheral sympathetic nervous activity, the use of such devices in combination with biofeedback for the treatment of epilepsy, and its potential for improving epilepsy specialist services, particularly in remote areas. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.03.002DOI Listing

Proliferation of NG2 cells in the epileptic hippocampus.

Epilepsy Res 2019 05 12;152:67-72. Epub 2019 Mar 12.

Radiation Physiology Laboratory, Singapore Nuclear Research and Safety Initiative (SNRSI), National University of Singapore, 1 CREATE Way #04-01, CREATE Tower, 138602, Singapore. Electronic address:

NG2 cells are oligodendrocyte progenitor cells, and have been shown to receive synaptic input from pyramidal neurons to generate action potentials. Whether any change of these cells occurs after status epilepticus (SE) and subsequent temporal lobe epilepsy remains unknown. In the present study, the expression of NG2 was investigated in the mouse hippocampus after pilocarpine-induced status epilepticus (PISE). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09201211183051
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http://dx.doi.org/10.1016/j.eplepsyres.2019.03.006DOI Listing
May 2019
3 Reads

Frontal lobe dysfunction as a predictor of depression and anxiety following temporal lobe epilepsy surgery.

Epilepsy Res 2019 05 19;152:59-66. Epub 2019 Mar 19.

Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, London, United Kingdom; The National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom. Electronic address:

Objective: Predictors of psychiatric outcome following TLE surgery have proved elusive and represent a current challenge in the practice of TLE surgery. This prospective study investigated whether frontal lobe dysfunction is predictive of poorer psychiatric outcomes.

Methods: Forty-nine unilateral TLE surgical patients were assessed using the Beck Depression Inventory-Fast Screen (BDI-FS) and Beck Anxiety Inventory (BAI) preoperatively and 6 and 12 months postoperatively. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.03.003DOI Listing

Association between ambient air pollution and hospital admission for epilepsy in Eastern China.

Epilepsy Res 2019 05 25;152:52-58. Epub 2019 Feb 25.

Medical Informatics Center, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100191, China; Department of Epidemiology and Biostatistics, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100191, China. Electronic address:

Background: We aimed to study the short-term association between air pollutants and hospitalization for epilepsy in 47 hospitals from 10 cities in eastern China.

Method: We identified hospital epilepsy admissions in 2014 and 2015. A conditional Poisson regression model was used to examine the association between air pollutants and hospital admission, with temperature and relative humidity adjusted using the natural spline (ns) function. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09201211183029
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http://dx.doi.org/10.1016/j.eplepsyres.2019.02.012DOI Listing
May 2019
2 Reads

Effective connectivity analysis of iEEG and accurate localization of the epileptogenic focus at the onset of operculo-insular seizures.

Epilepsy Res 2019 05 11;152:42-51. Epub 2019 Mar 11.

Polystim Neurotech Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada.

Recognition of insular epilepsy may sometimes be challenging due to the rapid speed at which insular seizures can spread throughout the cortex via extensive connections to surrounding cortices. The spectrum weighted adaptive directed transfer function, a multivariate causality-based effective connectivity measure, was applied to intracranial electroencephalography recordings to identify generators of seizure activity. A non-parametric test based on surrogate data testing was used to validate statistical significance of causal relations. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.02.006DOI Listing

Sustained elevation of cerebrospinal fluid glucose and lactate after a single seizure does not parallel with mitochondria energy production.

Epilepsy Res 2019 05 11;152:35-41. Epub 2019 Mar 11.

Programa de Pós-graduação em Ciências Biológicas, Bioquímica, Laboratório de Neurotrauma e Biomarcadores, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. Electronic address:

Generalized seizures trigger excessive neuronal firing that imposes large demands on the brain glucose/lactate availability and utilization, which synchronization requires an integral mitochondrial oxidative capability. We investigated whether a single convulsive crisis affects brain glucose/lactate availability and mitochondrial energy production. Adult male Wistar rats received a single injection of pentylentetrazol (PTZ, 60 mg/kg, i. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09201211183064
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http://dx.doi.org/10.1016/j.eplepsyres.2019.03.007DOI Listing
May 2019
4 Reads

AQB-565 shows promise in preclinical testing in the model of epileptic spasms during infancy: Head-to-head comparison with ACTH.

Epilepsy Res 2019 05 11;152:31-34. Epub 2019 Mar 11.

Department of Cell Biology & Anatomy, New York Medical College School of Medicine, Valhalla, NY, 10595, USA; Department of Neurology, New York Medical College School of Medicine, Valhalla, NY, 10595, USA; Department of Pediatrics, New York Medical College School of Medicine, Valhalla, NY, 10595, USA. Electronic address:

Epileptic spasms during infancy (infantile spasms) represent a serious treatment and social problem despite their rare occurrence. Current treatments include hormonal therapy (adrenocorticotropin-ACTH or corticosteroids) or vigabatrin (per se or in the combination). These treatments are partially effective and with potentially significant adverse effects. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09201211193004
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http://dx.doi.org/10.1016/j.eplepsyres.2019.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450730PMC
May 2019
7 Reads

Identifying mutations in epilepsy genes: Impact on treatment selection.

Epilepsy Res 2019 05 4;152:18-30. Epub 2019 Mar 4.

Division of Clinical and Experimental Pharmacology, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy; Clinical Trial Center, IRCCS Mondino Foundation, Pavia, Italy.

The last decade saw impressive advances not only in the discovery of gene mutations causing epilepsy, but also in unraveling the molecular mechanisms underlying the clinical manifestations of the disease. Increasing evidence is emerging that understanding these mechanisms is relevant for selection of the most appropriate treatment in the affected individual(s). The present article discusses the therapeutic implications of epilepsy-causing variants affecting a broad range of targets, from ion channels to genes controlling cellular metabolism and cell signaling pathways. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.03.001DOI Listing
May 2019
5 Reads

Longitudinal change of cardiac electrical and autonomic function and potential risk factors in children with dravet syndrome.

Epilepsy Res 2019 05 28;152:11-17. Epub 2019 Feb 28.

Department of Pediatrics, Kosin University Gospel Hospital, Kosin University, Busan, Republic of Korea.

Purpose: This study aimed to investigate cardiac electrical and autonomic function, the longitudinal changes, and the associated risk factors in children with Dravet syndrome (DS).

Methods: Twenty-four children with DS (11 boys, 13 girls; mean age, 7.2 ± 2. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09201211183061
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http://dx.doi.org/10.1016/j.eplepsyres.2019.02.018DOI Listing
May 2019
3 Reads

Historical trend toward improved long-term outcome in childhood absence epilepsy.

Epilepsy Res 2019 05 25;152:7-10. Epub 2019 Feb 25.

Department of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut, 06520, USA; Department of Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut, 06520, USA; Department of Neurosurgery, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut, 06520, USA. Electronic address:

We retrospectively analyzed published studies to investigate historical trends in outcome of childhood absence epilepsy (CAE). We included patients based on onset of absence seizures in childhood, 3 Hz bilateral spike-wave discharges on EEG, and availability of seizure-free outcome data. The primary endpoint was seizure-freedom off medications by study publication year. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.02.013DOI Listing

Perampanel-induced weight gain depends on level of intellectual disability and its serum concentration.

Epilepsy Res 2019 05 25;152:1-6. Epub 2019 Feb 25.

North Tohoku Epilepsy Center, Minato Hospital, Hachinohe, Aomori, Japan.

Background: Body weight (BW) gain may be induced by perampanel (PER) administration, similar to the well-known adverse effects of valproic acid and gabapentin. Intellectual disability (ID) and serum PER concentration may be risk factors of BW gain.

Purpose: This study investigated how ID and serum PER concentration are associated with PER-induced BW gain. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.02.011DOI Listing
May 2019
1 Read

Brain-responsive neurostimulation for epilepsy (RNS System).

Epilepsy Res 2019 Feb 20. Epub 2019 Feb 20.

NeuroPace, Inc., Mountain View, CA, United States; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, United States.

Controlled clinical trials in adults with medically intractable focal seizures treated with the RNS System demonstrate that closed-loop responsive neurostimulation to the seizure focus reduces the frequency of disabling seizures, is well tolerated, and is acceptably safe. Seizure reductions begin with initiation of treatment and continue over time, reaching median reductions of 75% after 9 years of treatment. Treatment with responsive cortical stimulation is also associated with improvement in quality of life and cognitive function related to the functional area being treated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09201211183057
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http://dx.doi.org/10.1016/j.eplepsyres.2019.02.003DOI Listing
February 2019
5 Reads

Multimodal wrist-worn devices for seizure detection and advancing research: Focus on the Empatica wristbands.

Epilepsy Res 2019 Feb 27. Epub 2019 Feb 27.

Empatica, Milan, Italy; Empatica, Cambridge, MA, USA; MIT Media Lab, Massachusetts Institute of Technology, Cambridge, MA, USA.

Wearable automated seizure detection devices offer a high potential to improve seizure management, through continuous ambulatory monitoring, accurate seizure counts, and real-time alerts for prompt intervention. More importantly, these devices can be a life-saving help for people with a higher risk of sudden unexpected death in epilepsy (SUDEP), especially in case of generalized tonic-clonic seizures (GTCS). The Embrace and E4 wristbands (Empatica) are the first commercially available multimodal wristbands that were designed to sense the physiological hallmarks of ongoing GTCS: while Embrace only embeds a machine learning-based detection algorithm, both E4 and Embrace devices are equipped with motion (accelerometers, ACC) and electrodermal activity (EDA) sensors and both the devices received medical clearance (E4 from EU CE, Embrace from EU CE and US FDA). Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.02.007DOI Listing
February 2019
6 Reads

Increased expression of DOC2A in human and rat temporal lobe epilepsy.

Epilepsy Res 2019 03 25;151:78-84. Epub 2019 Feb 25.

Department of Neurology, Chongqing Traditional Chinese Medicine Hospital, 6Panxizhi Road, Chongqing 400021, China. Electronic address:

Temporal lobe epilepsy (TLE) is the most common form of intractable epilepsy. Currently, the molecular mechanisms underlying epileptogenesis in TLE remain elusive; however, synaptic transmission may play an important role in the pathogenesis of epilepsy. Synaptic transmission is regulated by diverse mechanisms, including presynaptic modulators of synaptic vesicle formation and release, modulators of neurotransmission and distinct Ca sensors. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09201211183044
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http://dx.doi.org/10.1016/j.eplepsyres.2019.02.008DOI Listing
March 2019
7 Reads

Brand-to-generic oxcarbazepine switch - A prospective observational study.

Epilepsy Res 2019 03 27;151:75-77. Epub 2019 Feb 27.

Dept. of Neurology, Jagiellonian University Medical College, Krakow, Poland.

Purpose: To determine the clinical outcomes of brand-to- generic oxcarbazepine (OXC) switch in patients with epilepsy.

Methods: This prospective observational study included 103 patients treated with OXC in the tertiary outpatient epilepsy clinic. In 2016 the price of the brand-name OXC in Poland increased by 10 times in comparison to the generic products. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.02.017DOI Listing
March 2019
4 Reads

Deficiency of urokinase-type plasminogen activator and its receptor affects social behavior and increases seizure susceptibility.

Epilepsy Res 2019 03 25;151:67-74. Epub 2019 Feb 25.

Epilepsy Research Laboratory, A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, PO Box 1627, FI-70211 Kuopio, Finland. Electronic address:

Extracellular proteolysis initiated by the binding of urokinase-type plasminogen activator (uPA) to its receptor (uPAR) regulates the development of inhibitory neuronal circuits in the cerebral cortex and tissue remodeling after epileptogenic brain injury. To study the function of different components of the uPA-uPAR system on behavior and epileptogenesis, and to complement our previous studies on naïve and injured mice deficient in the uPA-encoding gene Plau or the uPAR-encoding gene Plaur, we analyzed the behavioral phenotype, seizure susceptibility, and perineuronal nets surrounding parvalbumin-positive inhibitory interneurons in Plau and Plaur (double knockout dKO) mice. In a climbing test, dKO mice showed reduced interest towards the environment as compared with Wt mice (p < 0. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.02.009DOI Listing
March 2019
3 Reads

Network pharmacology for antiepileptogenesis: Tolerability and neuroprotective effects of novel multitargeted combination treatments in nonepileptic vs. post-status epilepticus mice.

Epilepsy Res 2019 03 25;151:48-66. Epub 2019 Feb 25.

Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, 30559 Hannover, Germany; Center for Systems Neuroscience, 30559 Hannover, Germany. Electronic address:

Network-based approaches in drug discovery comprise both development of novel drugs interacting with multiple targets and repositioning of drugs with known targets to form novel drug combinations that interact with cellular or molecular networks whose function is disturbed in a disease. Epilepsy is a complex network phenomenon that, as yet, cannot be prevented or cured. We recently proposed multitargeted, network-based approaches to prevent epileptogenesis by combinations of clinically available drugs chosen to impact diverse epileptogenic processes. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.02.010DOI Listing

30 years of vagus nerve stimulation trials in epilepsy: Do we need neuromodulation-specific trial designs?

Epilepsy Res 2019 Feb 20. Epub 2019 Feb 20.

Laboratory for Clinical and Experimental Neurophysiology, Neurobiology and Neuropsychology, Department of Neurology, Ghent University, Ghent, Belgium.

Neuromodulation therapies represent an important treatment arm for patients with drug-resistant epilepsy (DRE) who are not candidates for resective surgery. Vagus nerve stimulation (VNS) - the neurostimulation modality in focus in this review - was the first available neuromodulatory therapy for DRE and was followed by anterior thalamic deep brain stimulation (ANT-DBS) and responsive neurostimulation (RNS). Although no comparative trials of these treatments have been performed, published data and clinical experience suggest comparable effectiveness. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09201211183057
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http://dx.doi.org/10.1016/j.eplepsyres.2019.02.004DOI Listing
February 2019
9 Reads
2.015 Impact Factor

Autonomic biofeedback therapy in epilepsy.

Authors:
Yoko Nagai

Epilepsy Res 2019 Feb 20. Epub 2019 Feb 20.

Trafford Centre, Brighton and Sussex Medical School, University of Sussex, Falmer, Brighton, BN1 9RR, United Kingdom. Electronic address:

Pharmacological intervention is a mainstay for treatment of epilepsy. However, a third of patients with epilepsy remain drug resistant. Behavioural treatments such as biofeedback training can be potential effective alternative interventions for drug resistant epilepsy. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.02.005DOI Listing
February 2019
3 Reads

Medicare claims can identify post-stroke epilepsy.

Epilepsy Res 2019 03 8;151:40-47. Epub 2019 Feb 8.

Mongan Institute, Department of Medicine, Massachusetts General Hospital, 100 Cambridge Street, Boston, MA, 02114, USA; Department of Health Care Policy, Harvard Medical School, 677 Huntington Avenue, Boston, MA, 02115, USA. Electronic address:

Objective: There have been no validated Medicare claims-based algorithms available to identify epilepsy by discrete etiology of stroke (e.g., post-stroke epilepsy, PSE) in community-dwelling elderly individuals, despite the increasing availability of large datasets. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.02.002DOI Listing

Cannabis for refractory epilepsy in children: A review focusing on CDKL5 Deficiency Disorder.

Epilepsy Res 2019 03 5;151:31-39. Epub 2019 Feb 5.

Telethon Kids Institute, University of Western Australia, Perth, WA, Australia(2). Electronic address:

Severe paediatric epilepsies such as CDKL5 Deficiency Disorder (CDD) are extremely debilitating, largely due to the early-onset and refractory nature of the seizures. Existing treatment options are often ineffective and associated with a host of adverse effects, causing those that are affected to seek alternative treatments. Cannabis based products have attracted significant attention over recent years, primarily driven by reports of miraculous cures and a renewed public preference for 'natural' therapies, thus placing intense pressure on health professionals and the government for regulatory change. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.02.001DOI Listing
March 2019
3 Reads

Sustained somatostatin gene expression reverses kindling-induced increases in the number of dividing Type-1 neural stem cells in the hippocampi of behaviorally responsive rats.

Epilepsy Res 2019 02 11;150:78-94. Epub 2019 Jan 11.

J. Crayton Pruitt Family Department of Biomedical Engineering, USA; Department of Neuroscience, USA; McKnight Brain Institute, USA. Electronic address:

Neurogenesis persists throughout life in the hippocampi of all mammals, including humans. In the healthy hippocampus, relatively quiescent Type-1 neural stem cells (NSCs) can give rise to more proliferative Type-2a neural progenitor cells (NPCs), which generate neuronal-committed Type-2b NPCs that mature into Type-3 neuroblasts. Many Type-3 neuroblasts survive and mature into functionally integrated granule neurons over several weeks. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.01.005DOI Listing
February 2019
2 Reads

Electrical cortical stimulation for refractory focal epilepsy: A long-term follow-up study.

Epilepsy Res 2019 03 9;151:24-30. Epub 2019 Jan 9.

Section of Epilepsy, Department of Neurology, Chang Gung Memorial Hospital Linkou Medical Center and Chang Gung University College of Medicine, Taoyuan, Taiwan; Department of Neurology, Xiamen Changgung Hospital, China. Electronic address:

Objective: To report the long-term seizure control and safety of open-loop electrical cortical stimulation in patients with refractory focal epilepsy of diverse etiologies.

Methods: Six patients who received a therapeutic trial of cortical stimulation were included retrospectively. The frequency of seizures was recorded before and after implantation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09201211183049
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http://dx.doi.org/10.1016/j.eplepsyres.2019.01.003DOI Listing
March 2019
14 Reads
2.015 Impact Factor

Neuropsychological outcomes after resection of cortical sites with visual naming associated electrocorticographic high-gamma modulation.

Epilepsy Res 2019 03 29;151:17-23. Epub 2019 Jan 29.

Comprehensive Epilepsy Center, Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

Background: Language mapping with high-gamma modulation (HGM) has compared well with electrical cortical stimulation mapping (ESM). However, there is limited prospective data about its functional validity. We compared changes in neuropsychological evaluation (NPE) performed before and 1-year after epilepsy surgery, between patients with/without resection of cortical sites showing HGM during a visual naming task. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.01.011DOI Listing
March 2019
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Strong relationship between NREM sleep, epilepsy and plastic functions - A conceptual review on the neurophysiology background.

Epilepsy Res 2019 02 31;150:95-105. Epub 2019 Jan 31.

National Institute of Clinical Neuroscience, Amerikai út 57. Budapest, H-1145, Hungary.

The aim of this review is to summarize and discuss the strong bond between NREM sleep and epilepsy underlain by the shared link and effect on brain plasticity. Beyond the seizure occurrence rate, sleep relatedness may manifest in the enhancement of interictal epileptic discharges (spikes and pathological ripples). The number of the discharges as well as their propagation increase during NREM sleep, unmasking the epileptic network that is hidden during wakefulness. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2018.11.008DOI Listing
February 2019
2.015 Impact Factor

Harmonization of lateral fluid-percussion injury model production and post-injury monitoring in a preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis.

Epilepsy Res 2019 03 18;151:7-16. Epub 2019 Jan 18.

A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Finland.

Multi-center preclinical studies can facilitate the discovery of biomarkers of antiepileptogenesis and thus facilitate the diagnosis and treatment development of patients at risk of developing post-traumatic epilepsy. However, these studies are often limited by the difficulty in harmonizing experimental protocols between laboratories. Here, we assess whether the production of traumatic brain injury (TBI) using the lateral fluid-percussion injury (FPI) in adult male Sprague-Dawley rats (12 weeks at the time of injury) was harmonized between three laboratories - located in the University of Eastern Finland (UEF), Monash University in Melbourne, Australia (Melbourne) and The University of California, Los Angeles, USA (UCLA). Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.01.006DOI Listing

Preface - Practical and theoretical considerations for performing a multi-center preclinical biomarker discovery study of post-traumatic epileptogenesis: lessons learned from the EpiBioS4Rx consortium.

Epilepsy Res 2019 Jan 18. Epub 2019 Jan 18.

Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, United States.

The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) is a NINDS funded Center-Without-Walls international study aimed at preventing epileptogenesis after traumatic brain injury (TBI). One objective of EpiBioS4Rx relates to preclinical biomarker discovery for post-traumatic epilepsy. In order to perform a statistically appropriately powered biomarker discovery study, EpiBioS4Rx has made a rigorous attempt to harmonize the preclinical procedures performed at the three EpiBioS4Rx centers, located in Finland, Australia, and the USA. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.01.007DOI Listing
January 2019
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Protective effects of lycopene on kainic acid-induced seizures.

Epilepsy Res 2019 03 17;151:1-6. Epub 2019 Jan 17.

School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, China.

Lycopene (LCP) is a carotenoid that protects against many diseases by alleviating oxidative stress. However, the effect of LCP on epileptic seizures has not been examined well in previous studies. In the current work, we employed kainic acid (KA) to induce experimental epileptic seizures in mice, and investigated the function of LCP during this process. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.01.010DOI Listing
March 2019
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Genetic testing in a cohort of patients with potential epilepsy with myoclonic-atonic seizures.

Epilepsy Res 2019 02 14;150:70-77. Epub 2019 Jan 14.

University of Colorado Denver, Department of Pediatrics, Section of Neurology, United States.

Epilepsy with myoclonic-atonic seizures (EMAS) accounts for 1-2% of all childhood-onset epilepsies. EMAS has been shown to have an underlying genetic component, however the genetics of this disorder is not yet well understood. The purpose of this study was to review genetic testing results for a cohort of EMAS patients. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.01.008DOI Listing
February 2019
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Sudden unexpected death in GEFS+ families with sodium channel pathogenic variants.

Epilepsy Res 2019 02 14;150:66-69. Epub 2019 Jan 14.

Research Institute of the McGill University Health Center, 2155 Guy Street, Montreal, PQ, H3H 2L9, Canada; Department of Pediatrics, Division of Child Neurology, Montreal Children's Hospital, McGill University Health Centre, 1001 Boulevard Décarie, Montreal, PQ, H4A 3J1, Canada.

We aimed to describe families with genetic epilepsy with febrile seizures plus (GEFS+) in which individuals suffered sudden unexpected death. The Epilepsy Pharmacogenomics Research Database was reviewed for GEFS + families in which at least one individual had suffered sudden death, and two families were identified. In Family A, five males had febrile seizures and one girl had febrile seizures plus. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.01.009DOI Listing
February 2019
5 Reads

Cognitive, behavioural and sleep-related adverse effects on introduction of levetiracetam versus oxcarbazepine for epilepsy.

Epilepsy Res 2019 02 8;150:58-65. Epub 2019 Jan 8.

Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.

Objective: There is limited literature on cognitive, behaviour and sleep-related adverse effects of levetiracetam and oxcarbazepine among adult epilepsy patients, except for what is available from the initial efficacy trials. This study was initiated with the aim to evaluate the incidence and prevalence of various cognitive, behaviour and sleep-related adverse effects of levetiracetam versus oxcarbazepine among people with epilepsy.

Methods: The study was conducted in two parts: part A was a cross-sectional study, and part B was a longitudinal study. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.01.004DOI Listing
February 2019
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Harmonization of pipeline for preclinical multicenter MRI biomarker discovery in a rat model of post-traumatic epileptogenesis.

Epilepsy Res 2019 02 7;150:46-57. Epub 2019 Jan 7.

A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, FIN-70211 Kuopio, Finland.

Preclinical imaging studies of posttraumatic epileptogenesis (PTE) have largely been proof-of-concept studies with limited animal numbers, and thus lack the statistical power for biomarker discovery. Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) is a pioneering multicenter trial investigating preclinical imaging biomarkers of PTE. EpiBios4Rx faced the issue of harmonizing the magnetic resonance imaging (MRI) procedures and imaging data metrics prior to its execution. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.01.001DOI Listing
February 2019
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Pharmacokinetic evaluation of vigabatrin dose for the treatment of refractory focal seizures in children using adult and pediatric data.

Epilepsy Res 2019 02 7;150:38-45. Epub 2019 Jan 7.

INSERM U1129, Paris, France; Paris Descartes University, CEA, Gif-sur-Yvette, France; Service de Pharmacologie, Hôpital Européen Georges Pompidou, 20 rue Leblanc, 75015 Paris, France. Electronic address:

Vigabatrin is indicated as adjunctive therapy for refractory focal seizures. For children, European recommendations indicate maintenance doses varying from 30 to 100 mg/kg/day for this indication. Since cumulated dose was associated with retinal toxicity, it is essential to administrate the lowest effective dose to patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09201211183031
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http://dx.doi.org/10.1016/j.eplepsyres.2019.01.002DOI Listing
February 2019
14 Reads

Corrigendum to "Lithium affects rat hippocampal electrophysiology and epileptic seizures in a dose dependent manner" [Epilepsy Res. 146 (2018) 112-120].

Epilepsy Res 2019 02 11;150:107-108. Epub 2019 Jan 11.

Department of Neurology, Institute of Neurological Diseases, Affiliated Hospital of North Sichuan Medical College, 63 Wenhua Road, Nanchong 637000, China. Electronic address:

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http://dx.doi.org/10.1016/j.eplepsyres.2018.12.002DOI Listing
February 2019
4 Reads

Conductive gel bridge sensor for motion tracking in simultaneous EEG-fMRI recordings.

Epilepsy Res 2019 01 17;149:117-122. Epub 2018 Dec 17.

Sagol Brain Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

EEG-fMRI allows the localization of the hemodynamic correlates of neural activity and has been shown to be useful as a diagnostic tool in pre-surgical evaluation of refractory epilepsy. However, EEG recordings may be highly contaminated by artifacts induced by movements inside the magnetic field thus rendering the scan difficult for interpretation. Existing methods for motion correction require additional equipment or hardware modification. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09201211183027
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http://dx.doi.org/10.1016/j.eplepsyres.2018.12.008DOI Listing
January 2019
3 Reads

Levodropropizine suppresses seizure activity in rats with pentylenetetrazol-induced epilepsy.

Epilepsy Res 2019 02 29;150:32-37. Epub 2018 Dec 29.

Department of Physiology, Faculty of Medicine, Bilim University, Istanbul, Turkey. Electronic address:

Background: Millions of individuals worldwide suffer from epilepsy, and up to 25% of patients have seizures that are resistant to currently available antiepileptic drugs. Hence, there continues to be a need for more seizure medications that are effective yet tolerable. Levodropropizine (LVDP) is an established antitussive drug that, based on preclinical data, may also have antiepileptic activity. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09201211183039
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http://dx.doi.org/10.1016/j.eplepsyres.2018.12.011DOI Listing
February 2019
5 Reads