4,558 results match your criteria Epilepsy Research[Journal]


Medicare claims can identify post-stroke epilepsy.

Epilepsy Res 2019 Feb 8;151:40-47. Epub 2019 Feb 8.

Mongan Institute, Department of Medicine, Massachusetts General Hospital, 100 Cambridge Street, Boston, MA, 02114, USA; Department of Health Care Policy, Harvard Medical School, 677 Huntington Avenue, Boston, MA, 02115, USA. Electronic address:

Objective: There have been no validated Medicare claims-based algorithms available to identify epilepsy by discrete etiology of stroke (e.g., post-stroke epilepsy, PSE) in community-dwelling elderly individuals, despite the increasing availability of large datasets. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.02.002DOI Listing
February 2019

Cannabis for refractory epilepsy in children: A review focusing on CDKL5 Deficiency Disorder.

Epilepsy Res 2019 Feb 5;151:31-39. Epub 2019 Feb 5.

Telethon Kids Institute, University of Western Australia, Perth, WA, Australia(2). Electronic address:

Severe paediatric epilepsies such as CDKL5 Deficiency Disorder (CDD) are extremely debilitating, largely due to the early-onset and refractory nature of the seizures. Existing treatment options are often ineffective and associated with a host of adverse effects, causing those that are affected to seek alternative treatments. Cannabis based products have attracted significant attention over recent years, primarily driven by reports of miraculous cures and a renewed public preference for 'natural' therapies, thus placing intense pressure on health professionals and the government for regulatory change. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.02.001DOI Listing
February 2019
1 Read

Sustained somatostatin gene expression reverses kindling-induced increases in the number of dividing Type-1 neural stem cells in the hippocampi of behaviorally responsive rats.

Epilepsy Res 2019 Feb 11;150:78-94. Epub 2019 Jan 11.

J. Crayton Pruitt Family Department of Biomedical Engineering, USA; Department of Neuroscience, USA; McKnight Brain Institute, USA. Electronic address:

Neurogenesis persists throughout life in the hippocampi of all mammals, including humans. In the healthy hippocampus, relatively quiescent Type-1 neural stem cells (NSCs) can give rise to more proliferative Type-2a neural progenitor cells (NPCs), which generate neuronal-committed Type-2b NPCs that mature into Type-3 neuroblasts. Many Type-3 neuroblasts survive and mature into functionally integrated granule neurons over several weeks. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.01.005DOI Listing
February 2019
2 Reads

Electrical cortical stimulation for refractory focal epilepsy: A long-term follow-up study.

Epilepsy Res 2019 Jan 9;151:24-30. Epub 2019 Jan 9.

Section of Epilepsy, Department of Neurology, Chang Gung Memorial Hospital Linkou Medical Center and Chang Gung University College of Medicine, Taoyuan, Taiwan; Department of Neurology, Xiamen Changgung Hospital, China. Electronic address:

Objective: To report the long-term seizure control and safety of open-loop electrical cortical stimulation in patients with refractory focal epilepsy of diverse etiologies.

Methods: Six patients who received a therapeutic trial of cortical stimulation were included retrospectively. The frequency of seizures was recorded before and after implantation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09201211183049
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http://dx.doi.org/10.1016/j.eplepsyres.2019.01.003DOI Listing
January 2019
8 Reads
2.015 Impact Factor

Neuropsychological outcomes after resection of cortical sites with visual naming associated electrocorticographic high-gamma modulation.

Epilepsy Res 2019 Jan 29;151:17-23. Epub 2019 Jan 29.

Comprehensive Epilepsy Center, Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

Background: Language mapping with high-gamma modulation (HGM) has compared well with electrical cortical stimulation mapping (ESM). However, there is limited prospective data about its functional validity. We compared changes in neuropsychological evaluation (NPE) performed before and 1-year after epilepsy surgery, between patients with/without resection of cortical sites showing HGM during a visual naming task. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.01.011DOI Listing
January 2019
2 Reads

Strong relationship between NREM sleep, epilepsy and plastic functions - A conceptual review on the neurophysiology background.

Epilepsy Res 2019 Feb 31;150:95-105. Epub 2019 Jan 31.

National Institute of Clinical Neuroscience, Amerikai út 57. Budapest, H-1145, Hungary.

The aim of this review is to summarize and discuss the strong bond between NREM sleep and epilepsy underlain by the shared link and effect on brain plasticity. Beyond the seizure occurrence rate, sleep relatedness may manifest in the enhancement of interictal epileptic discharges (spikes and pathological ripples). The number of the discharges as well as their propagation increase during NREM sleep, unmasking the epileptic network that is hidden during wakefulness. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2018.11.008DOI Listing
February 2019

Harmonization of lateral fluid-percussion injury model production and post-injury monitoring in a preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis.

Epilepsy Res 2019 Jan 18;151:7-16. Epub 2019 Jan 18.

A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Finland.

Multi-center preclinical studies can facilitate the discovery of biomarkers of antiepileptogenesis and thus facilitate the diagnosis and treatment development of patients at risk of developing post-traumatic epilepsy. However, these studies are often limited by the difficulty in harmonizing experimental protocols between laboratories. Here, we assess whether the production of traumatic brain injury (TBI) using the lateral fluid-percussion injury (FPI) in adult male Sprague-Dawley rats (12 weeks at the time of injury) was harmonized between three laboratories - located in the University of Eastern Finland (UEF), Monash University in Melbourne, Australia (Melbourne) and The University of California, Los Angeles, USA (UCLA). Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.01.006DOI Listing
January 2019

Preface - Practical and theoretical considerations for performing a multi-center preclinical biomarker discovery study of post-traumatic epileptogenesis: lessons learned from the EpiBioS4Rx consortium.

Epilepsy Res 2019 Jan 18. Epub 2019 Jan 18.

Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, United States.

The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) is a NINDS funded Center-Without-Walls international study aimed at preventing epileptogenesis after traumatic brain injury (TBI). One objective of EpiBioS4Rx relates to preclinical biomarker discovery for post-traumatic epilepsy. In order to perform a statistically appropriately powered biomarker discovery study, EpiBioS4Rx has made a rigorous attempt to harmonize the preclinical procedures performed at the three EpiBioS4Rx centers, located in Finland, Australia, and the USA. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.01.007DOI Listing
January 2019
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Protective effects of lycopene on kainic acid-induced seizures.

Epilepsy Res 2019 Jan 17;151:1-6. Epub 2019 Jan 17.

School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, China.

Lycopene (LCP) is a carotenoid that protects against many diseases by alleviating oxidative stress. However, the effect of LCP on epileptic seizures has not been examined well in previous studies. In the current work, we employed kainic acid (KA) to induce experimental epileptic seizures in mice, and investigated the function of LCP during this process. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.01.010DOI Listing
January 2019
1 Read

Genetic testing in a cohort of patients with potential epilepsy with myoclonic-atonic seizures.

Epilepsy Res 2019 Feb 14;150:70-77. Epub 2019 Jan 14.

University of Colorado Denver, Department of Pediatrics, Section of Neurology, United States.

Epilepsy with myoclonic-atonic seizures (EMAS) accounts for 1-2% of all childhood-onset epilepsies. EMAS has been shown to have an underlying genetic component, however the genetics of this disorder is not yet well understood. The purpose of this study was to review genetic testing results for a cohort of EMAS patients. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.01.008DOI Listing
February 2019
2 Reads

Sudden unexpected death in GEFS+ families with sodium channel pathogenic variants.

Epilepsy Res 2019 Feb 14;150:66-69. Epub 2019 Jan 14.

Research Institute of the McGill University Health Center, 2155 Guy Street, Montreal, PQ, H3H 2L9, Canada; Department of Pediatrics, Division of Child Neurology, Montreal Children's Hospital, McGill University Health Centre, 1001 Boulevard Décarie, Montreal, PQ, H4A 3J1, Canada.

We aimed to describe families with genetic epilepsy with febrile seizures plus (GEFS+) in which individuals suffered sudden unexpected death. The Epilepsy Pharmacogenomics Research Database was reviewed for GEFS + families in which at least one individual had suffered sudden death, and two families were identified. In Family A, five males had febrile seizures and one girl had febrile seizures plus. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.01.009DOI Listing
February 2019
3 Reads

Cognitive, behavioural and sleep-related adverse effects on introduction of levetiracetam versus oxcarbazepine for epilepsy.

Epilepsy Res 2019 Feb 8;150:58-65. Epub 2019 Jan 8.

Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.

Objective: There is limited literature on cognitive, behaviour and sleep-related adverse effects of levetiracetam and oxcarbazepine among adult epilepsy patients, except for what is available from the initial efficacy trials. This study was initiated with the aim to evaluate the incidence and prevalence of various cognitive, behaviour and sleep-related adverse effects of levetiracetam versus oxcarbazepine among people with epilepsy.

Methods: The study was conducted in two parts: part A was a cross-sectional study, and part B was a longitudinal study. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.01.004DOI Listing
February 2019
7 Reads

Harmonization of pipeline for preclinical multicenter MRI biomarker discovery in a rat model of post-traumatic epileptogenesis.

Epilepsy Res 2019 Feb 7;150:46-57. Epub 2019 Jan 7.

A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, FIN-70211 Kuopio, Finland.

Preclinical imaging studies of posttraumatic epileptogenesis (PTE) have largely been proof-of-concept studies with limited animal numbers, and thus lack the statistical power for biomarker discovery. Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) is a pioneering multicenter trial investigating preclinical imaging biomarkers of PTE. EpiBios4Rx faced the issue of harmonizing the magnetic resonance imaging (MRI) procedures and imaging data metrics prior to its execution. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.01.001DOI Listing
February 2019
3 Reads

Pharmacokinetic evaluation of vigabatrin dose for the treatment of refractory focal seizures in children using adult and pediatric data.

Epilepsy Res 2019 Feb 7;150:38-45. Epub 2019 Jan 7.

INSERM U1129, Paris, France; Paris Descartes University, CEA, Gif-sur-Yvette, France; Service de Pharmacologie, Hôpital Européen Georges Pompidou, 20 rue Leblanc, 75015 Paris, France. Electronic address:

Vigabatrin is indicated as adjunctive therapy for refractory focal seizures. For children, European recommendations indicate maintenance doses varying from 30 to 100 mg/kg/day for this indication. Since cumulated dose was associated with retinal toxicity, it is essential to administrate the lowest effective dose to patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09201211183031
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http://dx.doi.org/10.1016/j.eplepsyres.2019.01.002DOI Listing
February 2019
7 Reads

Corrigendum to "Lithium affects rat hippocampal electrophysiology and epileptic seizures in a dose dependent manner" [Epilepsy Res. 146 (2018) 112-120].

Epilepsy Res 2019 Feb 11;150:107-108. Epub 2019 Jan 11.

Department of Neurology, Institute of Neurological Diseases, Affiliated Hospital of North Sichuan Medical College, 63 Wenhua Road, Nanchong 637000, China. Electronic address:

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http://dx.doi.org/10.1016/j.eplepsyres.2018.12.002DOI Listing
February 2019
2 Reads

Conductive gel bridge sensor for motion tracking in simultaneous EEG-fMRI recordings.

Epilepsy Res 2019 01 17;149:117-122. Epub 2018 Dec 17.

Sagol Brain Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

EEG-fMRI allows the localization of the hemodynamic correlates of neural activity and has been shown to be useful as a diagnostic tool in pre-surgical evaluation of refractory epilepsy. However, EEG recordings may be highly contaminated by artifacts induced by movements inside the magnetic field thus rendering the scan difficult for interpretation. Existing methods for motion correction require additional equipment or hardware modification. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09201211183027
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http://dx.doi.org/10.1016/j.eplepsyres.2018.12.008DOI Listing
January 2019
3 Reads

Levodropropizine suppresses seizure activity in rats with pentylenetetrazol-induced epilepsy.

Epilepsy Res 2019 Feb 29;150:32-37. Epub 2018 Dec 29.

Department of Physiology, Faculty of Medicine, Bilim University, Istanbul, Turkey. Electronic address:

Background: Millions of individuals worldwide suffer from epilepsy, and up to 25% of patients have seizures that are resistant to currently available antiepileptic drugs. Hence, there continues to be a need for more seizure medications that are effective yet tolerable. Levodropropizine (LVDP) is an established antitussive drug that, based on preclinical data, may also have antiepileptic activity. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09201211183039
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http://dx.doi.org/10.1016/j.eplepsyres.2018.12.011DOI Listing
February 2019
4 Reads

High-frequency oscillations and spikes running down after SEEG-guided thermocoagulations in the epileptogenic network of periventricular nodular heterotopia.

Epilepsy Res 2019 Feb 15;150:27-31. Epub 2018 Dec 15.

Aix Marseille University, Institut de Neurosciences des Systèmes, Inserm, U1106, Marseille, France; Aix Marseille University, Service de Neurophysiologie Clinique, Hôpital Timone, Marseille, France. Electronic address:

Objective: Epilepsy associated with periventricular nodular heterotopia (PNH) is characterized by complex relationships between the heterotopic and the normotopic cortex during the interictal state and at seizure onset. High-frequency oscillations (HFO) have been proposed as a marker of epileptogenicity that might reflect disease activity. The effects of thermocoagulations on epileptogenicity in this context remain unknown. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2018.12.006DOI Listing
February 2019
2 Reads

Curcumin's antiepileptic effect, and alterations in Na1.1 and Na1.6 expression in iron-induced epilepsy.

Epilepsy Res 2019 Feb 15;150:7-16. Epub 2018 Dec 15.

Neurobiology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, 110067, India. Electronic address:

The present study was carried out to evaluate: the antiepileptic effect of dietary curcumin, and the effect of epileptic state and curcumin on the molecular expression of voltage-activated Na channel subtypes Na1.1 and Na1.6 in the iron-induced experimental epilepsy in the rat. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2018.12.007DOI Listing
February 2019
2 Reads
2.015 Impact Factor

Informatics tools to assess the success of procedural harmonization in preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis.

Epilepsy Res 2019 Feb 27;150:17-26. Epub 2018 Dec 27.

A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.

The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) is a National Institutes for Neurological Diseases and Stoke funded Centers-Without-Walls international multidisciplinary study aimed at preventing epileptogenesis. The preclinical biomarker discovery in EpiBios4Rx applies a multicenter study design to allow the number of animals that are required for adequate statistical power for the analysis to be studied in an efficient manner. Further, the use of multiple centers mimics the clinical trial situation, and therefore potentially the chance of successful clinical translation of the outcomes of the study. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2018.12.010DOI Listing
February 2019
1 Read

Corrigendum to "The effect of serum levetiracetam concentrations on therapeutic response and IL1-beta concentration in patients with epilepsy" [Epilepsy Res. 148 (2018) 17-22].

Epilepsy Res 2019 Feb 28;150:106. Epub 2018 Dec 28.

Department of Medical Pharmacology, School of Medicine, University of Marmara, Istanbul, Turkey. Electronic address:

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http://dx.doi.org/10.1016/j.eplepsyres.2018.12.004DOI Listing
February 2019
2 Reads

Focal epilepsy without interictal spikes on scalp EEG: A common finding of uncertain significance.

Epilepsy Res 2019 Feb 24;150:1-6. Epub 2018 Dec 24.

Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. Electronic address:

Objective: Interictal epileptiform discharges (IEDs) are important to identify the epileptogenic zone and to define epileptic syndromes. However, not all patients show IEDs on scalp EEG. We evaluate the likelihood of not findings spikes on prolonged Video-EEG Monitoring (VEM) in patients with focal epilepsy, and explore clinical correlates. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09201211183050
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http://dx.doi.org/10.1016/j.eplepsyres.2018.12.009DOI Listing
February 2019
41 Reads
2.015 Impact Factor

Vitamin D protects against hippocampal apoptosis related with seizures induced by kainic acid and pentylenetetrazol in rats.

Epilepsy Res 2019 01 15;149:107-116. Epub 2018 Dec 15.

Department of Pediatric Neurology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.

Objectives: The hippocampus is susceptible to damage in patients with epilepsy and in animals with seizures caused by excitotoxic agents. The effect of vitamin D on hippocampal apoptosis related with seizures has not been reported. However, epileptic patients have an increased risk of hypovitaminosis D which is most likely due to the effects of antiepileptic drugs. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2018.12.005DOI Listing
January 2019
1 Read

Potential protein-binding displacement interactions with perampanel: An in vitro analysis.

Epilepsy Res 2019 01 12;149:102-106. Epub 2018 Dec 12.

Drug Metabolism and Pharmacokinetics, Eisai Co., Ltd., 5-1-3 Tokodai, Tsukuba, Ibaraki 300-2635, Japan.

Plasma protein binding and effects on volume of distribution and pharmacologically active, circulating-drug concentrations are complex issues. Protein-binding displacement often underlies drug-drug interactions. Perampanel is a once-daily oral anti-seizure drug for focal seizures and primary generalized tonic-clonic seizures. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09201211183045
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http://dx.doi.org/10.1016/j.eplepsyres.2018.12.003DOI Listing
January 2019
22 Reads

Harmonization of pipeline for preclinical multicenter plasma protein and miRNA biomarker discovery in a rat model of post-traumatic epileptogenesis.

Epilepsy Res 2019 01 26;149:92-101. Epub 2018 Nov 26.

A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.

The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) is an international, multicenter, multidisciplinary study aimed at preventing epileptogenesis (EpiBioS4Rx: https://epibios.loni.usc. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2018.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326854PMC
January 2019
5 Reads

Intravenous brivaracetam in status epilepticus: Correlation between loading dose, plasma levels and clinical response.

Epilepsy Res 2019 01 3;149:88-91. Epub 2018 Dec 3.

Department of Clinical Neurosciences, Neurology Service, University Hospital (CHUV) and Faculty of Biology and Medicine of Lausanne, Switzerland. Electronic address:

Brivaracetam is available in intravenous formulation, and its favourable pharmacokinetic profile makes it a promising agent in the treatment of status epilepticus (SE). Its availability as an intravenous formulation and its favourable pharmacokinetic profile make it a promising agent in the treatment of status epilepticus. Our aim was to assess the correlation between BRV exposure and clinical response. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2018.12.001DOI Listing
January 2019
1 Read

Age-dependent semiology of frontal lobe seizures.

Epilepsy Res 2019 01 23;149:83-87. Epub 2018 Oct 23.

Epilepsy Center, University Medical Center, University of Freiburg, Germany; Faculty of Medicine, University of Freiburg, Germany. Electronic address:

Introduction: Frontal lobe epilepsy is the second most frequent origin of focal epilepsy. Various studies have discussed localizing aspects of ictal signs in frontal lobe epilepsy; the effect of age on semiological manifestations has, however, not been analyzed so far.

Material And Methods: We retrospectively analyzed video-documented semiological signs in a cohort of 122 consecutive patients aged 0-70 years (mean age: 24. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09201211183040
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http://dx.doi.org/10.1016/j.eplepsyres.2018.10.007DOI Listing
January 2019
16 Reads

Inhibitory effects of chronic administration of vitamin D on pentylenetetrazole-induced seizures in mice.

Epilepsy Res 2019 01 28;149:76-82. Epub 2018 Nov 28.

Physiology Research Center, Kashan University of Medical Sciences, Kashan, Iran; Department of Pharmacology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran. Electronic address:

Vitamin D as a neuroactive steroid hormone plays an important role in the nervous system. Recent clinical and experimental studies have shown an association between vitamin D-related disorders and epilepsy. Therefore, this study was designed to examine the effects of chronic administration of vitamin D on pentylenetetrazole (PTZ)-induced seizure in mice. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2018.11.011DOI Listing
January 2019
2 Reads

Yield of laboratory testing in pediatric ketogenic diet patients: Critical assessment of abnormal results and impact on clinical care.

Epilepsy Res 2019 01 16;149:70-75. Epub 2018 Nov 16.

Children's Hospital of Colorado- Dietary Division, United States.

Objectives: To retrospectively assess the incidence of high beta hydroxybutyrate, low bicarbonate (BIC), high acyl carnitine, low selenium, low magnesium, low zinc, low phosphorus, in a cohort of supplemented patients treated with the ketogenic diet (KD) for medically intractable epilepsy. To analyze effect of age, duration of exposure to KD, type of KD, and route of KD intake on lab abnormalities. To analyze the incidence of clinically actionable results, resulting in medical interventions based on abnormal results and to analyze costs of testing. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2018.11.007DOI Listing
January 2019
3 Reads

Antiepileptic drug treatment during pregnancy and delivery in women with epilepsy-A retrospective single center study.

Epilepsy Res 2019 01 20;149:66-69. Epub 2018 Nov 20.

Department of Neurology, Rabin Medical Center - Beilinson Hospital, Petach Tikva, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:

Purpose: Antiepileptic drugs (AED) are among the most common teratogenic drugs prescribed to women of childbearing age. During pregnancy, the risk of seizures has to be weight against the use of AED treatment. Primary goal was to observe and describe AED treatment policy and its changes during an eleven-year period at our third referral center. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2018.11.010DOI Listing
January 2019
2 Reads

The molecular hallmarks of epigenetic effects mediated by antiepileptic drugs.

Epilepsy Res 2019 01 16;149:53-65. Epub 2018 Nov 16.

Departamento de Farmacobiología, Centro de Investigaciones y Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV), México. Electronic address:

Epilepsy is associated with several epigenetic changes, such as DNA methylation, histone modification, and alterations in the synthesis and functioning of non-coding RNAs (ncRNAs). Paradoxically, antiepileptic drugs (AEDs) that are widely used to control epilepsy may also induce epigenetic modifications and alter the structure of chromatin. As a consequence, changes in the expression of various factors involved in the pathology of epilepsy may positively or negatively affect the course of the disease. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09201211183017
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http://dx.doi.org/10.1016/j.eplepsyres.2018.11.006DOI Listing
January 2019
9 Reads

Ictal onset patterns of subdural intracranial electroencephalogram in children: How helpful for predicting epilepsy surgery outcome?

Epilepsy Res 2019 01 28;149:44-52. Epub 2018 Oct 28.

Department of Neurology, Division of Child Neurology, New York-Presbyterian Hospital/ Columbia University College of Physicians and Surgeons, 180 Fort Washington Avenue, New York, New York, USA. Electronic address:

Aims: We aimed to classify ictal onset patterns (IOPs) in pediatric patients undergoing intracranial electroencephalography (IEEG) to guide surgery for refractory epilepsy. We aimed to determine if morphology of IOPs can predict surgical outcome.

Materials And Methods: We performed a retrospective review of pediatric patients who underwent epilepsy surgery guided by subdural IEEG from 2007 to 2016. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2018.10.008DOI Listing
January 2019
3 Reads

Resting state functional connectivity patterns associated with pharmacological treatment resistance in temporal lobe epilepsy.

Epilepsy Res 2019 01 17;149:37-43. Epub 2018 Nov 17.

Laboratory of Neural Systems, The Rockefeller University, New York, NY, USA. Electronic address:

There are no functional imaging based biomarkers for pharmacological treatment response in temporal lobe epilepsy (TLE). In this study, we investigated whether there is an association between resting state functional brain connectivity (RsFC) and seizure control in TLE. We screened a large database containing resting state functional magnetic resonance imaging (Rs-fMRI) data from 286 epilepsy patients. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2018.11.002DOI Listing
January 2019
11 Reads

Corrigendum to "Vitamin D status in children with epilepsy treated with levetiracetam monotherapy", [Epilepsy Res. 148 (2018) 116].

Epilepsy Res 2019 01 22;149:123. Epub 2018 Nov 22.

Second Department of Pediatrics, National and Kapodistrian University of Athens, "Panagiotis and Aglaia Kyriakou" Children's Hospital Athens, Greece.

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http://dx.doi.org/10.1016/j.eplepsyres.2018.11.005DOI Listing
January 2019
1 Read

Beyond depression: The impact of executive functioning on quality of life in patients with temporal lobe epilepsy.

Epilepsy Res 2019 01 13;149:30-36. Epub 2018 Nov 13.

San Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA; Center for Multimodal Imaging and Genetics, University of California, San Diego, CA, USA; UCSD Comphrensive Epilepsy Center, San Diego, CA, USA; Department of Psychiatry, University of California, San Diego, CA, USA. Electronic address:

Objective: Individuals with temporal lobe epilepsy (TLE) often experience diminished quality of life (QoL). Although comorbid depression is one of the most recognized predictors of poor QoL in TLE, impairments in verbal memory (VM) and executive functioning (EF), have also been identified as risk factors, independent of other biological and psychosocial factors. In this study, we examine the contribution of depression, VM, and EF to QoL in 52 well-characterized medically-refractory TLE patients. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2018.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326842PMC
January 2019
1 Read

Higher transcription alleles of the MAOA-uVNTR polymorphism are associated with higher seizure frequency in temporal lobe epilepsy.

Epilepsy Res 2019 01 12;149:26-29. Epub 2018 Nov 12.

Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil; Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil. Electronic address:

Background: There is evidence of an imbalance in the neuromodulatory system mediated by serotonin (5-HT) in patients with drug-resistant temporal lobe epilepsy (TLE). This study analyzed the monoamine oxidase A promoter variable number of tandem repeats (MAOA-uVNTR) polymorphism in patients with temporal lobe epilepsy with hippocampal sclerosis (TLE-HS). Therefore, we assessed the association between this genetic variant and seizure predisposition and severity in patients with TLE-HS. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2018.11.003DOI Listing
January 2019
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Timing and selection of first antiseizure medication in patients with pediatric status epilepticus.

Epilepsy Res 2019 01 1;149:21-25. Epub 2018 Nov 1.

Division of Child Neurology, Children's National Health System, Washington, DC, United States. Electronic address:

Objective: Pediatric status epilepticus (SE) may be associated with significant morbidity. We sought to evaluate timing and selection of antiseizure medications (ASM) in patients presenting in SE to a pediatric emergency department (ED). We hypothesized that delays in initial treatment are associated with longer overall duration of SE. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2018.10.014DOI Listing
January 2019
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Changing effect of GABA B receptor antagonist CGP46381 after status epilepticus in immature rats.

Epilepsy Res 2019 01 2;149:17-20. Epub 2018 Nov 2.

Department of Developmental Epileptology, Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic. Electronic address:

Possible proconvulsant action of GABA receptor antagonist CGP46381 was studied 3 and 13 days after status epilepticus elicited in 12-day-old rats. GABAA-dependent activity was tested by pentylenetetrazol administration and found different in 15-day-old rats after status epiolepticus but not in the older group. The interaction of the two GABAergic systems should be studied in detail. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2018.11.001DOI Listing
January 2019
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Modeling and simulation for the evaluation of dose adaptation rules of intravenous lacosamide in children.

Epilepsy Res 2019 01 26;149:13-16. Epub 2018 Oct 26.

UCB Pharma, Chemin du Foriest, 1420, Braine-l'Alleud, Belgium. Electronic address:

A combined adult and pediatric population pharmacokinetic model including covariate effects was developed; simulations were subsequently performed to guide intravenous pediatric dosing adaptations. Two pharmacokinetic trials with sparse blood sampling were conducted in children with epilepsy and two trials in healthy adults with serial blood sampling. Lacosamide plasma concentration-time data were available from 43 healthy adults (18-45 years of age; body weight 50-101 kg; n = 1735 concentration vs time records), and from 79 children with epilepsy (6 months-17 years of age; body weight 6-76 kg; n = 402 concentration vs time records), with 14, 22, 25 and 18 participants in age groups <2 years, 2 to <6 years, 6 to <12 years and 12 to <18 years, respectively. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09201211183025
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http://dx.doi.org/10.1016/j.eplepsyres.2018.10.011DOI Listing
January 2019
5 Reads
2.015 Impact Factor

Vitamin D status in children with epilepsy treated with levetiracetam monotherapy.

Epilepsy Res 2018 12;148:116

Second Department of Pediatrics, National and Kapodistrian University of Athens, "Panagiotis and Aglaia Kyriakou" Children's Hospital, Athens, Greece.

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https://linkinghub.elsevier.com/retrieve/pii/S09201211183044
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http://dx.doi.org/10.1016/j.eplepsyres.2018.09.003DOI Listing
December 2018
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Optimal recording duration of ambulatory EEG (aEEG).

Epilepsy Res 2019 01 3;149:9-12. Epub 2018 Aug 3.

Adult Stanford Comprehensive Epilepsy Center, United States.

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http://dx.doi.org/10.1016/j.eplepsyres.2018.07.025DOI Listing
January 2019
2 Reads

Seizures in tuberculous meningitis.

Epilepsy Res 2018 12 25;148:90-95. Epub 2018 Oct 25.

Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.

Objective: We report the frequency of seizure, its possible mechanisms and effect of seizure on the outcome of tuberculous meningitis (TBM).

Methods: Seventy-nine patients with TBM admitted during 2014-2017 were evaluated. The seizures were categorized as per International League Against Epilepsy as well as into early (within 1 month of meningitis) and late (>1 month) seizure. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2018.10.005DOI Listing
December 2018
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Development of propagated discharge and behavioral arrest in hippocampal and amygdala-kindled animals.

Epilepsy Res 2018 12 24;148:78-89. Epub 2018 Oct 24.

Institute of Medical Science, University of Toronto, Toronto, Canada; Department of Pharmacology & Toxicology, University of Toronto, Toronto, Canada.

Patients with focal temporal lobe seizures often experience transient episodes of impaired awareness with behavioral arrest, but the precise mechanism remains unknown. The Network Inhibition Hypothesis attributes these deficits to a loss of cholinergic input to the cortex. This is presumed to result from increased activation of inhibitory regions that suppress subcortical arousal, giving rise to cortical delta wave activity. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2018.10.010DOI Listing
December 2018
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Transient and permanent arterial occlusions modeling poststroke epilepsy in aging rats.

Epilepsy Res 2018 12 26;148:69-77. Epub 2018 Oct 26.

Neurology and Neuroscience Institute, Allegheny General Hospital, Allegheny Health Network, Pittsburgh, PA, 15212, United States; Neurology, Drexel University College of Medicine, Philadelphia, PA, 19102, United States; Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, 15213, United States; Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, 19129, United States. Electronic address:

The pathophysiological mechanisms of epileptogenesis following ischemic stroke in the aged brain are not well understood, largely due to limited developments in animal modeling of poststroke epilepsy (PSE). A recent study in our laboratory (Kelly et al., 2018) using transient (3 h) unilateral middle cerebral artery (MCA) and common carotid artery (CCA) occlusion (MCA/CCAo) in 4- and 20-month-old Fischer (F344) rats resulted in epileptic seizures in both age groups; age and infarction factors independently had effects on seizure frequency. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2018.10.012DOI Listing
December 2018
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Effect of acute caffeine administration on PTZ-induced seizure threshold in mice: Involvement of adenosine receptors and NO-cGMP signaling pathway.

Epilepsy Res 2019 01 29;149:1-8. Epub 2018 Oct 29.

Physiology Research Center, Kashan University of Medical Sciences, Kashan, Iran; Department of Physiology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran. Electronic address:

Purpose: Caffeine is a non-selective antagonist of A and A adenosine receptors (ARs). In this regard, nitric oxide (NO) is partly involved in the central effects of caffeine. In this study, we examined the effect of acute caffeine administration on pentylenetetrazole (PTZ)-induced seizure threshold by focusing on ARs, ARs, and NO-cGMP signaling pathway. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2018.10.013DOI Listing
January 2019
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Inequalities in the utilisation of epilepsy surgery for adults and children in Canada.

Epilepsy Res 2018 12 21;148:63-68. Epub 2018 Oct 21.

Centre hospitalier de l'Université de Montréal Research Centre, Montreal, QC, Canada; Department of Neurosciences, Université de Montréal, Montreal, QC, Canada. Electronic address:

Background: Epilepsy surgery is likely underutilised. Our goal was to study the utilisation of epilepsy surgery in the general population, using Canada as a model of a high-income country with universal medical coverage.

Methods: We systematically identified all epilepsy surgery centres in Canada that were active in 2015. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09201211183033
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http://dx.doi.org/10.1016/j.eplepsyres.2018.10.006DOI Listing
December 2018
25 Reads

Decision-making in patient s with epilepsy: A systematic review and meta-analysis.

Epilepsy Res 2018 12 22;148:55-62. Epub 2018 Oct 22.

Department of Neurology, West China Hospital, Sichuan University, Chengdu, China. Electronic address:

Objective: Decision-making (DM) is an essential ability in everyday life. Some studies have reported DM deficits in patients with epilepsy. However, the reliability of the conclusions was limited by small sample sizes and inconsistent results. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09201211183041
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http://dx.doi.org/10.1016/j.eplepsyres.2018.10.009DOI Listing
December 2018
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Invasive monitoring after resection of epileptogenic neocortical lesions in multistaged epilepsy surgery in children.

Epilepsy Res 2018 12 19;148:48-54. Epub 2018 Sep 19.

Division of Pediatric Neurosurgery, Department of Surgery, Texas Children's Hospital and Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.

Objective: Incomplete resection of neocortical epileptogenic foci correlates with failed epilepsy surgery in children. We often treat patients with neocortical epilepsy with a staged approach using invasive monitoring to localize the focus, resect the seizure onset zone, and, in select cases, post-resection invasive monitoring (PRM). We report the technique and the outcomes of children treated with staged surgery including PRM. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09201211173063
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http://dx.doi.org/10.1016/j.eplepsyres.2018.09.001DOI Listing
December 2018
16 Reads

Benefits of additional cardiologic examination in patients admitted for differential diagnosis to the Epilepsy Center Bethel.

Epilepsy Res 2018 12 16;148:44-47. Epub 2018 Oct 16.

Epilepsy Center Bethel, Krankenhaus Mara, Bielefeld, Germany.

Additional cardiologic examination for syncope is used for patients admitted for diagnostic reasons in the Epilepsy Center Bethel if, after epileptologic examination, the etiology of seizures remains uncertain and a cardiologic etiology is suspected. Therefore, we retrospectively analyzed all patient data from the diagnostic department between 02/2011 and 07/2015 to evaluate the benefits to patients of additional cardiologic examination for syncope. 78 out of 1567 patients underwent additional cardiologic examination for syncope. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2018.10.004DOI Listing
December 2018
3 Reads