1,451 results match your criteria Epilepsy Currents [Journal]


Treatment Works, So Who's Afraid of PNES?

Authors:
Jay Salpekar

Epilepsy Curr 2019 Mar-Apr;19(2):1535759719841354

Adherence With Psychotherapy and Treatment Outcomes for Psychogenic Nonepileptic Seizures Tolchin B, Dworetzky BA, Martino S, et al. Neurology. 2019;92(7):e675-e679. Read More

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http://dx.doi.org/10.1177/1535759719841354DOI Listing

High-Frequency Activity During Stereotyped Low-Frequency Events Might Help to Identify the Seizure Onset Zone.

Epilepsy Curr 2019 Mar-Apr;19(2):1535759719842236

Stereotyped high-frequency oscillations discriminate seizure onset zones and critical functional cortex in focal epilepsy. Liu S, Gurses C, Sha Z, Quach MM, Sencer A, Bebek N, et al. Brain. Read More

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http://dx.doi.org/10.1177/1535759719842236DOI Listing

A Straw Can Break a Neural Network's Back and Lead to Seizures-But Only When Delivered at the Right Time.

Epilepsy Curr 2019 Mar-Apr;19(2):115-116

Loss of Neuronal Network Resilience Precedes Seizures and Determines the Ictogenic Nature of Interictal Synaptic Perturbations Chang WC, Kudlacek J, Hlinka J, et al. Nat Neurosci. 2018; 21(12):1742-1752. Read More

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http://dx.doi.org/10.1177/1535759719835349DOI Listing
April 2019
1 Read

The Ambiguous Nature of Fast Ripples in Epilepsy Surgery.

Epilepsy Curr 2019 Mar-Apr;19(2):91-92

Removing High-Frequency Oscillations: A Prospective Multicenter Study on Seizure Outcome Jacobs J, Wu JY, Perucca P, et al. Neurology. 2018;91(11):e1040-e1052. Read More

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http://dx.doi.org/10.1177/1535759719835669DOI Listing
April 2019
4 Reads

Seizing Sequencing Data to Consider Cell and Circuit Complexity.

Epilepsy Curr 2019 Mar-Apr;19(2):124-125

Classes and Continua of Hippocampal CA1 Inhibitory Neurons Revealed by Single-Cell Transcriptomics Harris K, Hochgerner H, Skene NG, et al. PLoS Biol. 2018;16(6):e2006387. Read More

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http://dx.doi.org/10.1177/1535759719835658DOI Listing

Connecting Mind, Brain, and Seizures by Default Mode.

Authors:
Jay Salpekar

Epilepsy Curr 2019 Mar-Apr;19(2):103-104

Effective Connectivity Within the Default Mode Network in Left Temporal Lobe Epilepsy: Findings From the Epilepsy Connectome Project Cook CJ, Hwang G, Mathis J, et al. Brain Connect. 2018. Read More

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http://dx.doi.org/10.1177/1535759719837799DOI Listing
April 2019
1 Read

Cracklin' Fish Brains.

Epilepsy Curr 2019 Mar-Apr;19(2):112-114

Whole-Brain Neuronal Activity Displays Crackling Noise Dynamics Ponce-Alvarez A, Jouary A, Privat M, Deco G, Sumbre G. Neuron. 2018;100(6):1446-1459. Read More

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http://dx.doi.org/10.1177/1535759719835348DOI Listing
April 2019
1 Read

Losing Balance Over a Fatty Acid.

Authors:
Christina Gross

Epilepsy Curr 2019 Mar-Apr;19(2):129-131

Deficiency of AMPAR-Palmitoylation Aggravates Seizure Susceptibility Itoh M, Yamashita M, Kaneko M, Okuno H, Abe M, Yamazaki M, Natsume R, Yamada D, Kaizuka T, Suwa R, Sakimura K, Sekiguchi M, Wada K, Hoshino M, Mishina M, Hayashi T. J Neurosci. 2018;38(47):10220-10235. Read More

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http://journals.sagepub.com/doi/10.1177/1535759719835664
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http://dx.doi.org/10.1177/1535759719835664DOI Listing
April 2019
2 Reads

The Cost of the Second Seizure: Rethinking the Treatment Decision.

Authors:
Edward Faught

Epilepsy Curr 2019 Mar-Apr;19(2):88-90

Antiepileptic Drug Treatment After an Unprovoked First Seizure: A Decision Analysis Bao EL, Chao LY, Ni P, et al. Neurology. 2018;91(15):e1429-e1439. Read More

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http://dx.doi.org/10.1177/1535759719835367DOI Listing
April 2019
1 Read

The Dilemma of the Chicken or the Egg-What Appears First in TLE-Seizures or Morphometric Changes in the Temporal Lobe?

Epilepsy Curr 2019 Mar-Apr;19(2):101-102

Abnormal Temporal Lobe Morphology in Asymptomatic Relatives of Patients With Hippocampal Sclerosis: A Replication Study Yaakub SN, Barker GJ, Carr SJ, et al. Epilepsia. 2019;60(1):e1-e5. Read More

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http://dx.doi.org/10.1177/1535759719835675DOI Listing

Subacute Encephalopathy With Seizures in Alcoholics Syndrome: A Subtype of Nonconvulsive Status Epilepticus.

Epilepsy Curr 2019 Mar-Apr;19(2):77-82

4 Department of Neurology, Johns Hopkins University School of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, MD, USA.

A recent assessment of the classification of nonconvulsive status epilepticus (NCSE) has incorporated the specific electroencephalographic (EEG) patterns on a syndromic basis. Such a clinical EEG syndromic approach may enable more accurate and expedited diagnosis of particular subtypes of NCSE so as to improve therapy. Herein, we review the characteristics of subacute encephalopathy with seizures in alcoholics syndrome, a subtype of focal NCSE occurring in chronic alcoholism with specific features, including encephalopathy, lateralized periodic discharges on the EEG, chronic microvascular ischemia on neuroimaging studies, and possible recurrence when chronic antiseizure treatment is stopped. Read More

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http://dx.doi.org/10.1177/1535759719835676DOI Listing
April 2019
2 Reads

The Theta Stone: 3 to 10 Hz Oscillations to Decipher the Human Brain Code.

Epilepsy Curr 2019 Mar-Apr;19(2):126-128

Lateralized Hippocampal Oscillations Underlie Distinct Aspects of Human Spatial Memory and Navigation Miller J, Watrous AJ, Tsitsiklis M, et al. Nat Commun. 2018;9(1):2423. Read More

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http://dx.doi.org/10.1177/1535759719835662DOI Listing

PUMILIO1 Links Epilepsy to Spinocerebellar Ataxia.

Epilepsy Curr 2019 Mar-Apr;19(2):122-123

A Mild PUM1 Mutation Is Associated With Adult-Onset Ataxia, Whereas Haploinsufficiency Causes Developmental Delay and Seizures Gennarino VA, Palmer EE, McDonell LM, et al. Cell. 2018;172(5):924-936. Read More

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http://dx.doi.org/10.1177/1535759719835354DOI Listing

Valproic Acid Leads New Neurons Down the Wrong Path.

Authors:
Steve C Danzer

Epilepsy Curr 2019 Mar-Apr;19(2):132-133

Ectopic Neurogenesis Induced by Prenatal Antiepileptic Drug Exposure Augments Seizure Susceptibility in Adult Mice Sakai A, Matsuda T, Doi H, Nagaishi Y, Kato K, Nakashima K. Proc Natl Acad Sci U S A. 2018;115(16):4270-4275. Read More

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http://dx.doi.org/10.1177/1535759719835366DOI Listing
April 2019
6 Reads

Current Controversy: Spikes, Bursts, and Synchrony in Generalized Absence Epilepsy: Unresolved Questions Regarding Thalamocortical Synchrony in Absence Epilepsy.

Authors:
John Huguenard

Epilepsy Curr 2019 Mar-Apr;19(2):105-111

1 Department of Neurology, Stanford University School of Medicine, Stanford, CA, USA.

Absence epilepsy is a disorder of thalamocortical networks. Animal models have provided detailed information regarding the core cellular, synaptic, and network features that contribute to the electroencephalogram spike and wave discharge characteristic of typical absence epilepsy. Understanding of seizure networks and dynamics is a critical step toward improving treatments, yet competing conceptual models have evolved to explain seizure initiation and propagation. Read More

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http://dx.doi.org/10.1177/1535759719835355DOI Listing

When Epilepsy Grows Up….

Authors:
Katrina Boyer

Epilepsy Curr 2019 Mar-Apr;19(2):99-100

Neurocognition in Childhood Epilepsy: Impact on Mortality and Complete Seizure Remission 50 Years Later Sillanpää M, Saarinen MM, Karrasch M, Schmidt D, Hermann BP. Epilepsia. 2019;60(1):131-138. Read More

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http://dx.doi.org/10.1177/1535759719835674DOI Listing
April 2019
2 Reads

A New Hose to Extinguish the FIRES?

Authors:
Nicolas Gaspard

Epilepsy Curr 2019 Mar-Apr;19(2):86-87

Tocilizumab Treatment for New Onset Refractory Status Epilepticus Jun JS, Lee ST, Kim R, Chu K, Lee SK. Ann Neurol. 2018;84(6):940-945. Read More

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http://dx.doi.org/10.1177/1535759719835363DOI Listing

Don't Fear the Reefer-Evidence Mounts for Plant-Based Cannabidiol as Treatment for Epilepsy.

Authors:
M Scott Perry

Epilepsy Curr 2019 Mar-Apr;19(2):93-95

Effect of Cannabidiol on Drop Seizures in the Lennox-Gastaut Syndrome Devinsky O, Patel AD, Cross JH, et al; GWPCARE3 Study Group. N Engl J Med. 2018;378:1888-1897. Read More

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http://dx.doi.org/10.1177/1535759719835671DOI Listing
April 2019
7 Reads

Making Rash Decisions in Epilepsy: Evaluating Hypersensitivity Reactions to Anti-seizure Medications.

Epilepsy Curr 2019 Mar-Apr;19(2):96-98

The Frequency and Clinical Features of Hypersensitivity Reactions to Antiepileptic Drugs in Children: A Prospective Study Guvenir H, Dibek Misirlioglu E, Civelek E. J Allergy Clin Immunol Pract. 2018;6(6):2043-2050. Read More

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http://dx.doi.org/10.1177/1535759719835672DOI Listing
April 2019
1 Read

Comparative Risk of Major Congenital Malformations With 8 Different Antiepileptic Drugs: A Prospective Cohort Study of the EURAP Registry.

Authors:
David G Vossler

Epilepsy Curr 2019 Mar-Apr;19(2):83-85

Teratogenesis of 8 Antiepileptic Drugs in Multinational Experience Tomson T, Battino D, Bonizzoni E, Craig J, Lindhout D, Perucca E, Sabers A, Thomas SV, Vajda F for the EURAP Study Group. Lancet Neurol. 2018;17(6):530-538. Read More

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http://dx.doi.org/10.1177/1535759719835353DOI Listing
April 2019
1 Read

Are the Breaks Breaking Down?

Authors:
Laura A Ewell

Epilepsy Curr 2019 Mar-Apr;19(2):117-118

Altered Hippocampal Interneuron Activity Precedes Ictal Onset Miri ML, Vinck M, Pant R, Cardin JA. Elife. 2018;7. Read More

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http://dx.doi.org/10.1177/1535759719835350DOI Listing
April 2019
2 Reads

Fast-Spiking Interneurons Exposed in Tumor-Associated Epilepsy.

Authors:
Jamie Maguire

Epilepsy Curr 2019 Mar-Apr;19(2):119-121

Perineuronal Nets Decrease Membrane Capacitance of Peritumoral Fast Spiking Interneurons in a Model of Epilepsy Tewari BP, Chaunsali L, Campbell SL, Patel DC, Goode AE, and Sontheimer H. Nat Commun. 2018;9(1):4724. Read More

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http://dx.doi.org/10.1177/1535759719835351DOI Listing
April 2019
2 Reads

One-Hit Wonders and 2-Hit Tubers: A Second-Hit to TSC2 Causes Tuber-Like Cells in Spheroids.

Epilepsy Curr 2019 Jan 31;19(1):49-50. Epub 2019 Jan 31.

Genetically Engineered Human Cortical Spheroid Models of Tuberous Sclerosis Blair JD, Hockemeyer D, Bateup HS. Nat Med. 2018;24(10):1568-1578. Read More

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http://dx.doi.org/10.1177/1535759718822036DOI Listing
January 2019

Continuous EEG Monitoring-The Neurologist's Crystal Ball.

Authors:
Aatif M Husain

Epilepsy Curr 2019 Jan 30;19(1):24-26. Epub 2019 Jan 30.

Time to Epileptiform Activity and EEG Background Recovery Are Independent Predictors After Cardiac Arrest Westhall E, Rose I, Rundgren M, Bro-Jeppesen J, Kjaergaard J, Hassager C, Lindehammar H, Horn J, Ullen S, Nielsen N, Friberg H, Cronberg T. Clin Neurophysiol. 2018;129:1660-1668. Read More

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http://dx.doi.org/10.1177/1535759718822037DOI Listing
January 2019
2 Reads

Dravet Syndrome: A Developmental and Epileptic Encephalopathy.

Epilepsy Curr 2019 Jan 30;19(1):51-53. Epub 2019 Jan 30.

Selective Nav1.1 Activation Rescues Dravet Syndrome Mice From Seizures and Premature Death Richards KL, Milligan CJ, Richardson RJ, Jancovski N, Grunnet M, Jacobson LH, Undheim EAB, Mobli M, Chow CY, Herzig V, Csoti A, Panyi G, Reid CA, King GF, Petrou S. PNAS. Read More

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http://dx.doi.org/10.1177/1535759718822038DOI Listing
January 2019
15 Reads

The Space-Time Continuum of Cortical Dysplasia.

Authors:
Laura A Jansen

Epilepsy Curr 2019 Jan 30;19(1):54-56. Epub 2019 Jan 30.

Somatic Mutations Activating the mTOR Pathway in Dorsal Telencephalic Progenitors Cause a Continuum of Cortical Dysplasias D'Gama AM, Woodworth MB, Hossain AA, Bizzotto S, Hatem NE, LaCoursiere CM, Najm I, Ying Z, Yang E, Barkovich AJ, Kwiatkowski DJ, Vinters HV, Madsen JR, Mathern GW, Blümcke I, Poduri A, Walsh CA. Cell Rep. 2017;21:3754-3766. Read More

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http://dx.doi.org/10.1177/1535759718822039DOI Listing
January 2019
10 Reads

Seizures, Nonepileptic Events, Trauma, Anxiety, or All of the Above.

Authors:
Jay Salpekar

Epilepsy Curr 2019 Jan 30;19(1):29-30. Epub 2019 Jan 30.

Psychiatric Comorbidity and Traumatic Brain Injury Attribution in Patients With Psychogenic Nonepileptic or Epileptic Seizures: A Multicenter Study of US Veterans Salinsky M, Rutecki P, Parko K, Goy E, Storzbach D, O'Neil M, Binder L, Joos S. Epilepsia. 2018. Read More

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http://dx.doi.org/10.1177/1535759718822842DOI Listing
January 2019
3 Reads

Understanding the Cognitive Side Effects of Antiepileptic Drugs: Can Functional Imaging Be Helpful?

Authors:
William B Barr

Epilepsy Curr 2019 Jan 30;19(1):22-23. Epub 2019 Jan 30.

Effects of Carbamazepine and Lamotrigine on Functional Magnetic Resonance Imaging Cognitive Networks Xiao F, Caciagli L, Wandschneider B, Sander JW, Sidhu M, Winston G, Burdett J, Trimmel K, Hill A, Vollmar C, Vos SB, Ourselin S, Thompson PJ, Zhou D, Duncan JS, Koepp MJ. Epilepsia. 2018;59:1362-1371. Read More

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http://dx.doi.org/10.1177/1535759718822032DOI Listing
January 2019
3 Reads

Double agent mTOR.

Authors:
Steve C Danzer

Epilepsy Curr 2019 Jan 30;19(1):44-46. Epub 2019 Jan 30.

Remodeled Cortical Inhibition Prevents Motor Seizures in Generalized Epilepsy Jiang X, Lupien-Meilleur A, Tazerart S, Lachance M, Samarova E, Araya R, Lacaille JC, Rossignol E. Ann Neurol. 2018 Sep;84(3):436-451. Read More

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http://dx.doi.org/10.1177/1535759718822033DOI Listing
January 2019
3 Reads

Are Seizure Detection Devices Ready for Prime Time?

Authors:
Paul C Van Ness

Epilepsy Curr 2019 Jan 15;19(1):36-37. Epub 2019 Feb 15.

Standards for testing and clinical validation of seizure detection Beniczky S, Ryvlin P. Epilepsia. 2018;59(S1):9-13. Read More

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http://dx.doi.org/10.1177/1535759719827430DOI Listing
January 2019
4 Reads

Perceptions in PNES: A Bidirectional Problem.

Epilepsy Curr 2019 Jan 30;19(1):31-32. Epub 2019 Jan 30.

Health Care Practitioners' Perceptions of Psychogenic Nonepileptic Seizures: A Systematic Review of Qualitative and Quantitative Studies Rawlings GH, Reuber M. Epilepsia. 2018;59(6):1109-1123. Read More

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http://dx.doi.org/10.1177/1535759718823798DOI Listing
January 2019
2 Reads

THAR SHE BLOWS! The Search for the Great Spermine Whale of Carbamazepine Resistance.

Epilepsy Curr 2019 Jan 30;19(1):59-61. Epub 2019 Jan 30.

Polyamine Modulation of Anticonvulsant Drug Response: A Potential Mechanism Contributing to Pharmacoresistance in Chronic Epilepsy Beckonert NM, Opitz T, Pitsch J, Soares da Silva P, Beck H. J Neurosci. 2018;38(24):5596-5605. Read More

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http://dx.doi.org/10.1177/1535759718822034DOI Listing
January 2019

From DREADD to Treatment in Temporal Lobe Epilepsy.

Epilepsy Curr 2019 Jan 30;19(1):47-48. Epub 2019 Jan 30.

Pharmaco-Genetic Therapeutics Targeting Parvalbumin Neurons Attenuate Temporal Lobe Epilepsy Wang Y, Liang J, Chen L, Shen Y, Zhao J, Xu C, Wu X, Cheng H, Ying X, Guo Y, Wang S, Zhou Y, Wang Y, Chen Z. Neurobiol Dis. 2018;117:149-60. Read More

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http://dx.doi.org/10.1177/1535759718822035DOI Listing
January 2019
5 Reads

The Insula and Its Epilepsies.

Epilepsy Curr 2019 Jan 31;19(1):11-21. Epub 2019 Jan 31.

8 Northwell Health, Great Neck, NY, USA.

Insular seizures are great mimickers of seizures originating elsewhere in the brain. The insula is a highly connected brain structure. Seizures may only become clinically evident after ictal activity propagates out of the insula with semiology that reflects the propagation pattern. Read More

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http://dx.doi.org/10.1177/1535759718822847DOI Listing
January 2019
5 Reads

"Are We There Yet?" Quest for Treatment of Refractory Epilepsy.

Authors:
Libor Velíšek

Epilepsy Curr 2019 Jan 12;19(1):57-58. Epub 2019 Feb 12.

Biochemical Autoregulatory Gene Therapy for Focal Epilepsy Lieb A, Qiu Y, Dixon CL, Heller JP, Walker MC, Schorge S, Kullmann DM. Nat Med. 2018;24:1324-1329. Read More

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http://dx.doi.org/10.1177/1535759718822843DOI Listing
January 2019
3 Reads

A Matter of Genes: The Hurdles of Gene Therapy for Epilepsy.

Epilepsy Curr 2019 Jan 12;19(1):38-43. Epub 2019 Feb 12.

1 Department of Medical Sciences and National Institute of Neuroscience, University of Ferrara, Ferrara, Italy.

Gene therapy has recently advanced to the level of standard of care for several diseases. However, its application to neurological disorders is still in the experimental phase. In this review, we discuss recent advancements in the field that provide optimism on the possibility to have first-in-human studies for gene therapy of some forms of epilepsy in the not so distant future. Read More

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http://dx.doi.org/10.1177/1535759718822846DOI Listing
January 2019
3 Reads

Seize the Day for a Day With No Seizures: Modifiable Midlife Risk Factors Identified.

Epilepsy Curr 2019 Jan 30;19(1):27-28. Epub 2019 Jan 30.

Association Between Midlife Risk Factors and Late-Onset Epilepsy: Results From the Atherosclerosis Risk in Communities Study Johnson EL, Krauss GL, Lee AK, Schneider ALC, Dearborn JL, Kucharska-Newton AM, Huang J, Alonso A, Gottesman RF. JAMA Neurol. 2018 Jul 23 [Epub ahead of print] Importance: The incidence of epilepsy is higher in older age than at any other period of life. Read More

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http://dx.doi.org/10.1177/1535759718822041DOI Listing
January 2019
3 Reads

Medications for Early Life Epilepsy: Evidence Versus Experience?

Epilepsy Curr 2019 Jan 29;19(1):33-35. Epub 2019 Jan 29.

Comparative Effectiveness of Levetiracetam vs Phenobarbital for Infantile Epilepsy Grinspan ZM, Shellhaas RA, Coryell J, Sullivan JE, Wirrell EC, Mytinger JR, Gaillard WD, Kossoff EH, Valencia I, Knupp KG, Wusthoff C, Keator C, Ryan N, Loddenkemper T, Chu CJ, Novotny EJ Jr, Millichap J, Berg AT. JAMA Pediatr. 2018 Apr 1;172(4):352-360. Read More

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http://dx.doi.org/10.1177/1535759718822130DOI Listing
January 2019
4 Reads