1,413 results match your criteria Epilepsy Currents [Journal]


Genetics of Focal Epilepsies: What Do We Know and Where Are We Heading?

Authors:
Piero Perucca

Epilepsy Curr 2018 Nov-Dec;18(6):356-362

Senior Research Fellow, Department of Neuroscience, Central Clinical School, Monash University, Melbourne; Consultant Neurologist, Department of Neurology, The Royal Melbourne Hospital, Melbourne; Consultant Neurologist, Department of Neurology, Alfred Health, Melbourne; Honorary Senior Fellow, Melbourne Medical School, The University of Melbourne, Melbourne, VIC, Australia.

This article is based on a lecture delivered at the 2017 American Epilepsy Society Annual Meeting and provides an overview of the growing evidence supporting the strong genetic contribution to focal epilepsies. This also discusses how advances in the molecular genetics of focal epilepsies are rapidly translating to routine clinical care. Read More

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http://dx.doi.org/10.5698/1535-7597.18.6.356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278742PMC
December 2018
1 Read

A Metabolic Paradigm for Epilepsy.

Authors:
Manisha Patel

Epilepsy Curr 2018 Sep-Oct;18(5):318-322

University of Colorado, Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO.

There is a resurgence of interest in the role of metabolism in epilepsy. Long considered ancillary and acknowledged only in the context of clinical application of ketogenic diets, metabolic control of epilepsy is gaining momentum and mainstream interest among researchers. A metabolic paradigm for epilepsy rests upon known perturbations in three major interconnected metabolic nodes and therapeutic targets therefrom (i. Read More

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http://dx.doi.org/10.5698/1535-7597.18.5.318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224150PMC
November 2018
2 Reads

Let's Talk About Sex: Integrating Sex as a Biological Variable Into Epilepsy Research.

Authors:
Lia D Ernst

Epilepsy Curr 2018 Sep-Oct;18(5):292-294

OHSU Department of Neurology, Portland, OR.

There is a long history of underrepresentation of women and female animals being studied in scientific research, which has resulted in gaps in knowledge and at times, inaccurate clinical recommendations. There is a gradual shift in the mindset of the scientific community on this issue, in part related to policy changes enacted by the National Institute of Health (NIH). Sex must now be accounted for as a biological variable in both basic and clinical research. Read More

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http://dx.doi.org/10.5698/1535-7597.18.5.292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224139PMC
November 2018
9 Reads

Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs II: Treatment-resistant epilepsy: Report of the American Epilepsy Society and the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology.

Epilepsy Curr 2018 Jul-Aug;18(4):269-278

15New York University, New York City, NY.

To update the 2004 American Academy of Neurology (AAN) guideline for managing treatment-resistant (TR) epilepsy with second- and third-generation antiepileptic drugs (AEDs). 2004 criteria were used to systematically review literature (January 2003 to November 2015), classify pertinent studies according to the therapeutic rating scheme, and link recommendations to evidence strength. Forty-two articles were included. Read More

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http://dx.doi.org/10.5698/1535-7597.18.4.269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145395PMC
September 2018
5 Reads

Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs I: Treatment of new-onset epilepsy: Report of the American Epilepsy Society and the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology.

Epilepsy Curr 2018 Jul-Aug;18(4):260-268

15Department of Neurology, New York University Langone Comprehensive Epilepsy Center, New York.

To update the 2004 American Academy of Neurology (AAN) guideline for treating new-onset focal or generalized epilepsy (GE) with second- and third-generation antiepileptic drugs (AEDs). The 2004 AAN criteria was used to systematically review literature (January 2003 to November 2015), classify pertinent studies according to the therapeutic rating scheme, and link recommendations to evidence strength. Several second-generation AEDs are effective for new-onset focal epilepsy. Read More

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http://dx.doi.org/10.5698/1535-7597.18.4.260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145382PMC
September 2018
16 Reads

Modeling Pediatric Epilepsy Through iPSC-Based Technologies.

Epilepsy Curr 2018 Jul-Aug;18(4):240-245

2Assistant Professor, The Ken & Ruth Davee Department of Neurology and Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL.

In the current review, we discuss the process of modeling pediatric epileptic encephalopathies with a focus on in vitro iPSC-based technologies. We highlight the potential benefits as well as the challenges of these approaches and propose appropriate standards for the field. Read More

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http://journals.sagepub.com/doi/10.5698/1535-7597.18.4.240
Publisher Site
http://dx.doi.org/10.5698/1535-7597.18.4.240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145379PMC
September 2018
7 Reads

Psychogenic Nonepileptic Seizures (PNES) as a Network Disorder - Evidence From Neuroimaging of Functional (Psychogenic) Neurological Disorders.

Epilepsy Curr 2018 Jul-Aug;18(4):211-216

2Departments of Psychiatry and Neurology, Alpert Medical School, Brown University Director of Neuropsychiatry and Behavioral Neurology, Rhode Island Hospital.

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http://epilepsycurrents.org/doi/10.5698/1535-7597.18.4.211
Publisher Site
http://dx.doi.org/10.5698/1535-7597.18.4.211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145391PMC
September 2018
8 Reads