140,817 results match your criteria Epilepsy Currents [Journal]


The refractory epilepsy screening tool for Lennox-Gastaut syndrome (REST-LGS).

Epilepsy Behav 2018 Dec 8;90:148-153. Epub 2018 Dec 8.

Icahn School of Medicine at Mount Sinai Health Systems, 10 Union Square East, Suite 5G, New York, NY 10003, USA. Electronic address:

Background: The complex clinical presentation and progression of Lennox-Gastaut syndrome (LGS) can complicate the accurate diagnosis of this severe, lifelong, childhood-onset epilepsy, often resulting in suboptimal treatment. The Refractory Epilepsy Screening Tool for LGS (REST-LGS) was developed to improve the identification of patients with LGS.

Methods: Using the Modified Delphi Consensus, a group of experts developed and tested the REST-LGS Case Report Form (CRF) comprising 8 criteria (4 major, 4 minor) considered potentially indicative of LGS. Read More

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December 2018

Regression in Children with Epilepsy.

Neurosci Biobehav Rev 2018 Dec 8. Epub 2018 Dec 8.

Department of Pediatrics, Dalhousie University and the IWK Health Centre, Canada.

Regression in children with epilepsy may involve loss of cognitive abilities, failure to progress or a slowing of developmental trajectory. A few seizures do not lead to regression. Large numbers of seizures may be associated with regression but the cause is an important cofounder. Read More

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December 2018

Synthesis and characterization of novel substituted thiophene derivatives and discovery of their carbonic anhydrase and acetylcholinesterase inhibition effects.

J Biochem Mol Toxicol 2018 Dec 10:e22261. Epub 2018 Dec 10.

Department of Chemistry, Faculty of Science, Ataturk University, Erzurum, Turkey.

Novel substituted thiophene derivatives (1, 2a-e, 3, and 4) were synthesized and their structures were characterized by infrared radiation, nuclear magnetic resonance, and mass analysis. These novel substituted thiophene derivatives were effective inhibitor compounds of the carbonic anhydrase I and II isozymes (hCA I and II), and acetylcholinesterase (AChE) enzyme with K values in the range of 447.28 to 1004. Read More

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December 2018
1.925 Impact Factor

The K 7 channel activator retigabine suppresses mouse urinary bladder afferent nerve activity without affecting detrusor smooth muscle K channel currents.

J Physiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Pharmacology, University of Vermont, Burlington, VT, 05405.

Key Points Summary: K 7 channels are a family of voltage-dependent K channels expressed in many cell types, which open in response to membrane depolarization to regulate cell excitability. Drugs that target K 7 channels are used clinically to treat epilepsy. Interestingly, these drugs also cause urinary retention, but it was unclear how. Read More

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December 2018

Novel features for capturing temporal variations of rhythmic limb movement to distinguish convulsive epileptic and psychogenic nonepileptic seizures.

Epilepsia 2018 Dec 9. Epub 2018 Dec 9.

Department of Electrical and Electronic Engineering, The University of Melbourne, Melbourne, Victoria, Australia.

Objective: To investigate the characteristics of motor manifestation during convulsive epileptic and psychogenic nonepileptic seizures (PNES), captured using a wrist-worn accelerometer (ACM) device. The main goal was to find quantitative ACM features that can differentiate between convulsive epileptic and convulsive PNES.

Methods: In this study, motor data were recorded using wrist-worn ACM-based devices. Read More

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December 2018

The complexity of neuroinflammation consequent to traumatic brain injury: from research evidence to potential treatments.

Acta Neuropathol 2018 Dec 7. Epub 2018 Dec 7.

Wicking Dementia Research and Education Centre, College of Health and Medicine, University of Tasmania, Hobart, TAS, Australia.

This review recounts the definitions and research evidence supporting the multifaceted roles of neuroinflammation in the injured brain following trauma. We summarise the literature fluctuating from the protective and detrimental properties that cytokines, leukocytes and glial cells play in the acute and chronic stages of TBI, including the intrinsic factors that influence cytokine responses and microglial functions relative to genetics, sex, and age. We elaborate on the pros and cons that cytokines, chemokines, and microglia play in brain repair, specifically neurogenesis, and how such conflicting roles may be harnessed therapeutically to sustain the survival of new neurons. Read More

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December 2018

The clinical and imaging features of gray matter heterotopia: a clinical analysis on 15 patients.

Neurol Sci 2018 Dec 10. Epub 2018 Dec 10.

Department of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, China.

Objective: To investigate the clinical and imaging features of gray matter heterotopia (GMH) and improve the clinicians' understanding of the disease.

Methods: A retrospective study was performed on 15 patients with GMH diagnosed at The Affiliated Hospital of Xuzhou Medical University from November 2014 to November 2016. Their clinical and imaging features are also summarized. Read More

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December 2018

Direct and Collateral Alterations of Functional Cortical Circuits in a Rat Model of Subcortical Band Heterotopia.

Cereb Cortex 2018 Dec 7. Epub 2018 Dec 7.

INMED, Aix-Marseille Université, INSERM UMR1249, Marseille, France.

Subcortical band heterotopia (SBH), also known as double-cortex syndrome, is a neuronal migration disorder characterized by an accumulation of neurons in a heterotopic band below the normotopic cortex. The majority of patients with SBH have mild to moderate intellectual disability and intractable epilepsy. However, it is still not clear how cortical networks are organized in SBH patients and how this abnormal organization contributes to improper brain function. Read More

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December 2018

Addressing Cultural Barriers to Diagnosis and Treatment of Epilepsy in Hispanic Communities.

JAMA Neurol 2018 Dec 10. Epub 2018 Dec 10.

Doctor of Medicine Program, Eastern Virginia Medical School, Norfolk, Virginia.

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December 2018

[Sudden death in epilepsy].

Rev Med Chil 2018 Aug;146(8):902-908

Liga Chilena contra la Epilepsia, Clínica Dávila, Clínica Universidad de los Andes, Santiago, Chile.

The risk of sudden unexpected death in patients with epilepsy (SUDEP), is 20 to 25 times greater than in the general population. This increased risk is seen specially in refractory epilepsy, with an incidence of 9:1,000 patients-years. Risk factors have been established based on retrospective studies, finding that the frequency of seizures, specially generalized tonic clonic seizures, is the most important one. Read More

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Differences in Neural Recovery From Acute Stress Between Cortisol Responders and Non-responders.

Front Psychiatry 2018 26;9:631. Epub 2018 Nov 26.

Research Division of Mind and Brain, Department of Psychiatry and Psychotherapy CCM, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Adaptive recovery from a stressor fosters resilience. So far, however, few studies have examined brain functional connectivity in the aftermath of stress, with inconsistent results reported. Focusing on the immediate recovery from psychosocial stress, the current study compared amygdala resting-state functional connectivity (RSFC) before and immediately after psychosocial stress between cortisol responders and non-responders. Read More

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November 2018

Syntaxin 1B Mediates Berberine's Roles in Epilepsy-Like Behavior in a Pentylenetetrazole-Induced Seizure Zebrafish Model.

Front Mol Neurosci 2018 26;11:378. Epub 2018 Nov 26.

NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Epilepsy is a neuronal dysfunction syndrome characterized by transient and diffusely abnormal discharges of neurons in the brain. Previous studies have shown that mutations in the () gene cause a familial, fever-associated epilepsy syndrome. It is unclear as to whether the gene also correlates with other stimulations such as flashing and/or mediates the effects of antiepileptic drugs. Read More

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November 2018

Inappropriate Laughter and Behaviours: How, What, and Why? Case of an Adult with Undiagnosed Gelastic Seizure with Hypothalamic Hamartoma.

Hawaii J Med Public Health 2018 Dec;77(12):319-324

John A. Burns School of Medicine, University of Hawai'i, Honolulu, HI (NLB,JCK,AS).

Gelastic seizures (GS) are a rare form of epilepsy characterized by inappropriate, uncontrolled laughter. They are highly associated with abnormal cognitive development and behavioral problems in patients. Research has shown that GS can originate from hypothalamic hamartomas (HH), non- neoplastic masses consisting of gray matter with large and small neurons interspersed with glial nuclei. Read More

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December 2018

Gastrodin exerts robust neuroprotection in the postischemic brain via its protective effect against Zn-toxicity and its anti-oxidative effects in astrocytes.

Anim Cells Syst (Seoul) 2018 30;22(6):429-437. Epub 2018 Nov 30.

Department of Anatomy, Inha University School of Medicine, Incheon, Republic of Korea.

Gastrodin (GAS) is a predominant bioactive constituent of the Chinese herbal medicine Tianma ( Blume). Many authors have reported GAS has the beneficial effect on diverse diseases of the CNS, including epilepsy, Alzheimer's disease, Parkinson's disease, and cerebral ischemia. Here, we report GAS exhibited a robust neuroprotective effect in an Sprague-Dawley rat model of stroke (transient middle cerebral artery occlusion, tMCAO), and show that the underlying molecular mechanism involves its protective effect against Zn-toxicity and its anti-oxidative effects in astrocytes. Read More

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November 2018

Editorial: New Directions in the Management of Status Epilepticus.

Front Neurol 2018 23;9:994. Epub 2018 Nov 23.

Department of Neuroscience and Experimental Therapeutics, Texas A&M University College of Medicine, Bryan, TX, United States.

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November 2018

Prevalence of childhood and adolescence epilepsy in Upper Egypt (desert areas).

Egypt J Neurol Psychiatr Neurosurg 2018 9;54(1):34. Epub 2018 Nov 9.

2Department of Neurology, Minia University, Minya, Egypt.

Background: A high prevalence of epilepsy in children is frequently found in developing countries.

Objective: This study aimed to determine the prevalence and clinical pattern of childhood and adolescence epilepsy in Upper Egypt.

Methods: This is a door-to-door study conducted on all inhabitants < 18 years in Al Kharga district and Al Qusier city (36,195 subjects). Read More

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November 2018

Improvement in Obsessive-Compulsive Disorder Following Right Anterior Temporal Lobectomy and Amygdalohippocampectomy in a Patient with Refractory Temporal Lobe Epilepsy with Right Mesial Temporal Sclerosis.

Ann Indian Acad Neurol 2018 Oct-Dec;21(4):321-324

Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.

There are reports of co-occurrence of obsessive-compulsive disorder (OCD) in patients with temporal lobe epilepsy (TLE). We present a report of a patient with refractory TLE due to hippocampal sclerosis with concomitant OCD on pharmacotherapy for both. She underwent surgery for standard anterior temporal lobectomy with amygdalohippocampectomy and reported improvement in obsessive-compulsive symptoms subsequently. Read More

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December 2018

Epidemiological Survey of Neurological Diseases in a Tribal Population Cluster in Gujarat.

Ann Indian Acad Neurol 2018 Oct-Dec;21(4):294-299

Psychologist, Neurology Foundation, Mumbai, Maharashtra, India.

Background: There are few community-based neuroepidemiological studies based in tribal communities. This cross-sectional community-based study explored the prevalence rates of neurological disorders in the tribal region of Kaparada in Gujarat.

Methodology: A two-stage methodology was used. Read More

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December 2018

Prevalence of Epilepsy and its Association with Exposure to : A Community Based, Case-control Study from Rural Northern India.

Ann Indian Acad Neurol 2018 Oct-Dec;21(4):263-269

Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, Punjab, India.

Objectives: Many community-based and hospital-based studies across the world have yielded contradictory results regarding association of positive serology and epilepsy. The present study was planned to analyze disease burden of epilepsy in rural community of North India and its association with exposure to in this part of the world.

Methods: A door-to-door screening survey was carried out in the rural community using a validated questionnaire for epilepsy by trained field workers, which was finally confirmed by trained neurologists. Read More

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December 2018

Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies.

Authors:

Nat Commun 2018 Dec 10;9(1):5269. Epub 2018 Dec 10.

The epilepsies affect around 65 million people worldwide and have a substantial missing heritability component. We report a genome-wide mega-analysis involving 15,212 individuals with epilepsy and 29,677 controls, which reveals 16 genome-wide significant loci, of which 11 are novel. Using various prioritization criteria, we pinpoint the 21 most likely epilepsy genes at these loci, with the majority in genetic generalized epilepsies. Read More

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December 2018

Novel Use of Responsive Neurostimulation (RNS System) in the Treatment of Super Refractory Status Epilepticus.

J Clin Neurophysiol 2018 Dec 6. Epub 2018 Dec 6.

Departments of Neurology and.

There are very few randomized controlled trials studying treatment of super refractory status epilepticus (SE), despite estimated occurrence in about 15% of SE cases and its association with high morbidity and mortality rates. Small case series and case reports have described use of neurostimulation, including vagal nerve stimulation, transcranial magnetic stimulation, and deep brain stimulation, to treat super refractory SE when medical interventions have failed. To our knowledge, this is the first reported case of responsive neurostimulation being used to successfully treat a case of super refractory SE. Read More

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December 2018

[DEPDC5, a new key to understand various epilepsies].

Authors:
Saeko Ishida

Nihon Yakurigaku Zasshi 2018 ;152(6):281-285

Laboratory of Molecular Neuroscience, Medical Research Institute (MRI), Tokyo Medical and Dental University (TMDU).

Epilepsy is one of the most frequent neurological disorders characterized by spontaneous and recurrent seizures. Most seizures last for the lifetime and the patients require long term therapies. However, about 30% of the patients are refractory to antiepileptic drugs. Read More

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January 2018

[Function of synaptic vesicle protein 2A (SV2A) as a novel therapeutic target for epilepsy].

Nihon Yakurigaku Zasshi 2018 ;152(6):275-280

Department of Pharmacology, Osaka University of Pharmaceutical Sciences.

Epilepsy is a chronic neurologic disease characterized by recurrent seizures, affecting nearly 1% of the population. Synaptic vesicle protein 2A (SV2A) is a membrane protein specifically expressed in synaptic vesicles and is now implicated in the pathogenesis of epileptic disorders. This is because 1) Sv2a-knockout mice exhibit severe seizures, 2) SV2A serves as a specific binding site for certain antiepileptics (e. Read More

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January 2018

[Epileptogenesis mediated by glial cells].

Nihon Yakurigaku Zasshi 2018 ;152(6):268-274

Department of Pediatrics, Interdisciplinary Graduate School of Medicine, University of Yamanashi.

Epilepsy is one of the most common diseases of the central nervous system. Many epilepsies are controllable because of the existence of different antiepileptic drugs with multiple mechanisms of action. However, about 30% of epilepsy is so-called refractory epilepsy in which existing drugs do not show enough therapeutic effects. Read More

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January 2018

Cortical stimulation for treatment of neurological disorders of hyperexcitability: a role of homeostatic plasticity.

Neural Regen Res 2019 Jan;14(1):34-38

Department of Anatomy and Cell Biology, Department of Neurological Surgery, Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA.

Hyperexcitability of neural network is a key neurophysiological mechanism in several neurological disorders including epilepsy, neuropathic pain, and tinnitus. Although standard paradigm of pharmacological management of them is to suppress this hyperexcitability, such as having been exemplified by the use of certain antiepileptic drugs, their frequent refractoriness to drug treatment suggests likely different pathophysiological mechanism. Because the pathogenesis in these disorders exhibits a transition from an initial activity loss after injury or sensory deprivation to subsequent hyperexcitability and paroxysmal discharges, this process can be regarded as a process of functional compensation similar to homeostatic plasticity regulation, in which a set level of activity in neural network is maintained after injury-induced activity loss through enhanced network excitability. Read More

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January 2019

The electroclinical features of idiopathic generalized epilepsy patients presenting with fixation-off sensitivity.

Epileptic Disord 2018 Dec 10. Epub 2018 Dec 10.

Epilepsy and Sleep Disorders Unit, Department of Neurology, The Fourth Military Medical University, Xi'an, 710032, China.

To determine the electroclinical features of fixation-off sensitivity (FOS) in patients with idiopathic generalized epilepsy (IGE). We searched the EEG database using the terms "fixation-off sensitivity" and "idiopathic generalized epilepsy" over a four-year period from March 2014 to April 2018 in the Xijing Hospital, Xi'an, China. FOS was evaluated according to the technique proposed by Panayiotopoulos. Read More

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December 2018

De novo absence status epilepticus in three paediatric patients: a new idiopathic epilepsy syndrome?

Epileptic Disord 2018 Dec 10. Epub 2018 Dec 10.

Hospital de Pediatría "La madre y el Niño", Formosa, Argentina.

Absence status epilepticus (ASE) is a prolonged generalized absence seizure that usually lasts for hours and can even last for days. The main symptom is the altered content of consciousness while the patient may be alert and partly responsive. We describe the electroclinical features, treatment, and evolution of three paediatric patients with de novo ASE with an excellent response to valproic acid (VPA). Read More

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December 2018

Hemiconvulsion-Hemiplegia-Epilepsy in a girl with cobalamin C deficiency.

Epileptic Disord 2018 Dec 10. Epub 2018 Dec 10.

Division of Neurology, Department of Pediatrics, Montreal Children's Hospital, McGill University,, Department of Neurology and Neurosurgery, McGill University,, Research Institute of the McGill University Health Centre.

Hemiconvulsion-Hemiplegia-Epilepsy initially involves an infantile presentation of febrile focal motor status epilepticus, with subsequent hemiplegia of the initially affected side. Months to years later, affected children go on to develop a chronic epilepsy with recurrent focal seizures which are often refractory to treatment. This uncommon paediatric epilepsy syndrome is poorly understood, with only a very small minority of cases associated with an underlying genetic or metabolic abnormality. Read More

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December 2018

A new home for the Genetic Literacy series.

Epileptic Disord 2018 Dec 10. Epub 2018 Dec 10.

Department of Neurology, University of California, San Francisco, California, USA.

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December 2018

Intractable apnoeic seizures in a child with a deletion typically associated with Williams syndrome.

Epileptic Disord 2018 Dec 10. Epub 2018 Dec 10.

Division of Pediatric Neurology, Department of Pediatrics, The Hospital for Sick Children, Toronto.

Williams-Beuren syndrome is rarely associated with epilepsy. One previously reported case showed an association with apnoeic seizures while a few other cases showed an association with infantile epileptic spasms and generalized and focal seizures. We report the case of a 13-month-old boy with a deletion typically associated with Williams-Beuren syndrome, who presented with isolated apnoeic seizures which were refractory to multiple antiepileptic drugs but partially responsive to the ketogenic diet. Read More

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December 2018

Improved decision-making and psychophysiological responses in mesial temporal lobe epilepsy after anterior temporal lobectomy.

Epileptic Disord 2018 Dec 10. Epub 2018 Dec 10.

Istanbul University, Cerrahpaşa Faculty of Medicine, Department of Neurology.

The somatic marker hypothesis is an influential model of human decision-making postulating that somatic feedback to the brain enhances decision-making in ambiguous circumstances, i.e. when the probabilities of various outcomes are unknown. Read More

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December 2018

Faciobrachial dystonic seizures expressed as epileptic spasms, followed by focal seizures in anti-LGI1 encephalitis: a video-polygraphic study.

Epileptic Disord 2018 Dec 10. Epub 2018 Dec 10.

Epilepsy Centre - Clinic of Nervous System Diseases, Riuniti Hospital, Foggia, Italy.

The origin of faciobrachial dystonic seizures in anti-LGI1 encephalitis is controversial due to a lack of neurophysiological characterization. We report a 68-year-old man with subacute anterograde memory loss and involuntary faciobrachial movements. Video-polygraphic recordings disclosed repetitive events characterized by sudden, short contraction of the upper limbs and ipsilateral hemiface. Read More

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December 2018

Epileptology of the first tonic-clonic seizure in adults and prediction of seizure recurrence.

Epileptic Disord 2018 Dec 10. Epub 2018 Dec 10.

Department of Clinical Neurophysiology and Epilepsy, Guy's & St Thomas' NHS Foundation Trust and Institute of Psychiatry, Psychology & Neuroscience, Division of Neuroscience, King's College London, UK.

The risk of seizure recurrence after a first unprovoked seizure is influenced by certain risk factors. To understand their effect in people with early diagnosed new epilepsy, we assessed the risk of recurrence of focal to bilateral tonic-clonic or generalized tonic-clonic seizures and the associated factors in a clinically well-characterized cohort of adults with a first unprovoked tonic-clonic seizure. We prospectively studied 150 consecutive adults with a first unprovoked tonic-clonic seizure and full clinical, EEG, and brain imaging assessment within the first four weeks. Read More

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December 2018

Early and long-term electroclinical features of patients with epilepsy and PCDH19 mutation.

Epileptic Disord 2018 Dec 10. Epub 2018 Dec 10.

Pediatric Neurology Department, Centre de Référence des Épilepsies Rares, Necker Enfants Malades Hospital, Paris, Inserm U1129, Paris; University Paris Descartes; CEA, Gif sur Yvette.

Protocadherin 19 (PCDH19) mutations have been identified in epilepsy in females with mental retardation as well as patients with a "Dravet-like" phenotype. We aimed to elucidate the electroclinical phenotype associated with PCDH19 mutation, which is currently difficult to identify at onset leading to a delay in diagnosis. We retrospectively reviewed clinical and EEG data for 13 consecutive patients with PCDH19 mutations or deletions diagnosed at our centers from 2009 to 2011, and followed these patients into adolescence and adulthood. Read More

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December 2018

Juvenile absence epilepsy relapsing as recurrent absence status, mimicking transient global amnesia, in an elderly patient.

Epileptic Disord 2018 Dec 10. Epub 2018 Dec 10.

IRCCS Institute of Neurological Sciences, Bologna, Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.

We describe a 68-year-old woman who had typical absence seizures since 14 years of age. The absences were refractory to treatment and persisted into adulthood, with no seizure-free periods until seizure control at 59 years of age. After six years of being seizure-free, she presented with an episode characterized by mental confusion, abnormal behaviour, and amnesia, lasting for several hours. Read More

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December 2018

Measurement equivalence of the short-form Quality of Life in Childhood Epilepsy Questionnaire (QOLCE-16).

Epilepsy Behav 2018 Dec 7;90:142-147. Epub 2018 Dec 7.

Department of Paediatrics, Western University, Canada; Department of Epidemiology and Biostatistics, Western University, Canada; Children's Health Research Institute, Lawson Health Research Institute, London, Ontario, Canada.

Objective: The aim of this study was to assess measurement equivalence in the 16-item short-form Quality of Life in Childhood Epilepsy Questionnaire (QOLCE-16) across age, sex, and time in a sample of children with newly diagnosed epilepsy.

Methods: Data came from 373 children participating in the Health-related Quality of Life in Children with Epilepsy Study (HERQULES), a multicenter prospective cohort study. Measurement equivalence was assessed using multigroup confirmatory factor analysis methods. Read More

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December 2018

Circulating levels of adipokines are altered in patients with temporal lobe epilepsy.

Epilepsy Behav 2018 Dec 7;90:137-141. Epub 2018 Dec 7.

Laboratório Interdisciplinar de Investigação Médica, Medical School, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil; Neuropsychiatry Program, Department of Psychiatry and Behavioral Sciences, School of Medicine, University of Texas Health Science Center at Houston, TX, United States.

Objective: A persistent low-grade inflammatory state has been described in patients with temporal lobe epilepsy (TLE) in the interictal period. Adipokines are cytokines produced by the adipose tissue that can influence inflammatory response. The purpose of this study was to evaluate the plasma levels of adipokines in patients with TLE in comparison with controls. Read More

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December 2018

High risk of anxiety and depression in caregivers of adult patients with epilepsy and its negative impact on patients' quality of life.

Epilepsy Behav 2018 Dec 7;90:132-136. Epub 2018 Dec 7.

Department of Neurology, Zhengzhou University People's Hospital, Henan Province, Zhengzhou 450003, China.

Objective: The objective of this study was to assess the anxiety and depression of caregivers of adult patients with epilepsy (PWE) and evaluate its effect on patient quality of life (QOL).

Method: One hundred sixty pairs of adult PWE and their caregivers were enrolled in our study. Quality of life in adult PWE was evaluated with the Quality of Life in Epilepsy Inventory-31 scale (QOLIE-31). Read More

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December 2018

Brivaracetam in adults with drug-resistant epilepsy and psychiatric comorbidities.

Epilepsy Behav 2018 Dec 7;90:129-131. Epub 2018 Dec 7.

Atkinson Morley Regional Neuroscience Centre, St George's University Hospitals NHS Foundation Trust, London, UK; Institute of Medical and Biomedical Education, St George's University of London, UK. Electronic address:

This is a case series of 25 patients with drug-resistant epilepsy and psychiatric comorbidities who started on brivaracetam (BRV) at St George's University Hospitals and Frimley Health in London. Median BRV dose was 150 mg for a median follow-up period of 8 months. Twenty had focal epilepsy, four had generalized epilepsies, and one had unclassified epilepsy; 76% had mood disorders (either depression or bipolar disorder), 12% intellectual disabilities with autism spectrum disorder and challenging behavior, and 12% psychoses. Read More

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December 2018

Psychosocial complications in juvenile myoclonic epilepsy.

Epilepsy Behav 2018 Dec 7;90:122-128. Epub 2018 Dec 7.

Department of Neurology, Drammen Hospital, Vestre Viken Hospital Trust, Drammen, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

Juvenile myoclonic epilepsy (JME) constitutes about 10% of all epilepsies. Because of executive dysfunction, people with JME may be prone to impulsivity and risk-taking behavior. Our aim was to investigate whether psychosocial issues associated with impulsivity are more prominent in people with JME than in those with other types of genetic generalized epilepsy (GGE). Read More

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December 2018

Risk factors for the use of antiepileptic drugs in patients with psychogenic nonepileptic seizures.

Epilepsy Behav 2018 Dec 7;90:119-121. Epub 2018 Dec 7.

Neuroscience Research Center, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.

Purpose: The aim of this study was to investigate the frequency of antiepileptic drug (AED) use in patients with psychogenic nonepileptic seizures (PNES) and to characterize the patients' historical risk factors that may be associated with such a practice.

Methods: In this retrospective database study, all patients with PNES, who were investigated at Shiraz Comprehensive Epilepsy Center at Shiraz University of Medical Sciences, from 2008 to 2018, were studied. Patients with concomitant epilepsy or abnormal Electroencephalogram (EEG) were not included. Read More

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December 2018

Executive functioning phenotypes in youth with epilepsy.

Epilepsy Behav 2018 Dec 7;90:112-118. Epub 2018 Dec 7.

Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., Cincinnati, OH 45229-3039, United States of America; University of Cincinnati, College of Medicine, United States of America.

Objective: The objectives of this study were to identify executive functioning (EF) phenotypes in youth with epilepsy and to examine whether phenotypes differ on psychosocial and medical outcomes (i.e., absence/presence of seizures in the past three months), health-related quality of life (HRQOL), and emotional and behavioral functioning. Read More

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December 2018

Intravenous brivaracetam in status epilepticus: Correlation between loading dose, plasma levels and clinical response.

Epilepsy Res 2018 Dec 3;149:88-91. Epub 2018 Dec 3.

Department of Clinical Neurosciences, Neurology Service, University Hospital (CHUV) and Faculty of Biology and Medicine of Lausanne, Switzerland. Electronic address:

Brivaracetam is available in intravenous formulation, and its favourable pharmacokinetic profile makes it a promising agent in the treatment of status epilepticus (SE). Its availability as an intravenous formulation and its favourable pharmacokinetic profile make it a promising agent in the treatment of status epilepticus. Our aim was to assess the correlation between BRV exposure and clinical response. Read More

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December 2018

Follow-up study on Chinese children with relapsing MOG-IgG-associated central nervous system demyelination.

Mult Scler Relat Disord 2018 Dec 3;28:4-10. Epub 2018 Dec 3.

Department of Pediatrics, Peking University First Hospital, Beijing, China. Electronic address:

Background: Some studies have reported clinical features of relapsing MOG-IgG-associated CNS demyelination principally in Caucasians children. It is not clear whether Chinese children share the same phenotype.

Objective: To delineate the clinical characteristics in Chinese children with relapsing MOG-IgG-associated demyelination. Read More

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December 2018

Simultaneously recorded intracranial and scalp high frequency oscillations help identify patients with poor postsurgical seizure outcome.

Clin Neurophysiol 2018 Nov 26;130(1):128-137. Epub 2018 Nov 26.

Epilepsy Centre, Medical Center - University of Freiburg, Germany. Electronic address:

Objective: High frequency oscillations (HFO) between 80-500 Hz are markers of epileptic areas in intracranial and maybe also scalp EEG. We investigate simultaneous recordings of scalp and intracranial EEG and hypothesize that scalp HFOs provide important additional clinical information in the presurgical setting.

Methods: Spikes and HFOs were visually identified in all intracranial scalp EEG channels. Read More

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November 2018

De novo temporal intermittent rhythmic delta activity after laser interstitial thermal therapy for mesial temporal lobe epilepsy predicts poor seizure outcome.

Clin Neurophysiol 2018 Nov 26;130(1):122-127. Epub 2018 Nov 26.

Department of Neurology, Mayo Clinic, Jacksonville, FL, USA.

Objective: To evaluate EEG abnormalities, particularly development of temporal intermittent rhythmic delta activity (TIRDA) after laser interstitial thermal therapy (LITT) and assess the role of further surgery after LITT.

Methods: We retrospectively identified consecutive cases of LITT for the prevalence of post-operative TIRDA. We assessed baseline demographics, clinical variables including age of seizure onset, age at surgery, pre-operative and post-operative EEG changes. Read More

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November 2018

Emotional Reaction to viewing one's own epileptic seizure.

Seizure 2018 Nov 24;64:34-40. Epub 2018 Nov 24.

Epilepsy Center, Freiburg University Medical Center, Germany.

Purpose: If consciousness or memory are impaired during an epileptic seizure, the patient may not experience or know how his/her own seizure looks like. It is disputed, whether being confronted with own seizures may lead to emotional stress or empower patients and decrease negative psychosocial consequences. We assessed patients' reactions to watching a video of their own seizure on measures of anxiety, depression and ten emotions. Read More

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November 2018

Retention rate of first antiepileptic drug in poststroke epilepsy: A nationwide study.

Seizure 2018 Nov 23;64:29-33. Epub 2018 Nov 23.

Department of Clinical Neuroscience, Sahlgrenska Academy, University of Gothenburg and Sahlgrenska University Hospital, Sweden. Electronic address:

Purpose: To describe the retention rates of first antiepileptic drugs (AEDs) in patients with poststroke epilepsy on a nationwide scale.

Methods: The Swedish Stroke Register, which has 94% coverage and high-resolution data on stroke, comorbidities, and disability, was cross-referenced to the National Patient Register, Drug Register, and Cause-of-Death Register. Patients with onset of AED-treated epilepsy after stroke in 2005-2010 were included. Read More

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November 2018