142,012 results match your criteria Epilepsy & Behavior[Journal]


A novel truncating mutation of dock7 gene with an early-onset non-encephalopathic epilepsy.

Seizure 2019 Jan 16;66:12-14. Epub 2019 Jan 16.

Marmara University, Medical Faculty, Department of Neuroradiology, Pendik, Istanbul, Turkey.

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http://dx.doi.org/10.1016/j.seizure.2019.01.010DOI Listing
January 2019

Assessing the localization accuracy and clinical utility of electric and magnetic source imaging in children with epilepsy.

Clin Neurophysiol 2019 Jan 31;130(4):491-504. Epub 2019 Jan 31.

Laboratory of Children's Brain Dynamics, Division of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Fetal-Neonatal Neuroimaging Developmental Science Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

Objective: To evaluate the accuracy and clinical utility of conventional 21-channel EEG (conv-EEG), 72-channel high-density EEG (HD-EEG) and 306-channel MEG in localizing interictal epileptiform discharges (IEDs).

Methods: Twenty-four children who underwent epilepsy surgery were studied. IEDs on conv-EEG, HD-EEG, MEG and intracranial EEG (iEEG) were localized using equivalent current dipoles and dynamical statistical parametric mapping (dSPM). Read More

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http://dx.doi.org/10.1016/j.clinph.2019.01.009DOI Listing
January 2019

Impaired prefrontal cortex-thalamus pathway in intractable temporal lobe epilepsy with aberrant executive control function: MRI evidence.

Clin Neurophysiol 2019 Jan 18;130(4):484-490. Epub 2019 Jan 18.

Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, PR China; Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, PR China. Electronic address:

Objectives: This study aimed to assess structural and functional connectivity alterations of the prefrontal cortex (PFC)-thalamus axis in individuals with unilateral intractable temporal lobe epilepsy (TLE) showing executive control function (ECF) impairment and to explore the potential mechanism.

Methods: Thirty-eight individuals with intractable left TLE and twenty-nine healthy controls (HCs) were recruited for diffusion tensor imaging (DTI) and resting-state fMRI (rs-fMRI) scanning. According to the ECF state, patients were assigned to normal and impaired ECF groups. Read More

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http://dx.doi.org/10.1016/j.clinph.2018.12.007DOI Listing
January 2019

Factors associated with early seizures after surgery of unruptured intracranial aneurysms.

Clin Neurol Neurosurg 2019 Feb 8;178:93-96. Epub 2019 Feb 8.

Department of Cerebrovascular Surgery, International Medical Center, Saitama Medical University, Hidaka, Japan. Electronic address:

Objective: The aim of the study was to better define the incidence of and risk factors for early seizures after repair of unruptured intracranial aneurysms in modern microsurgical techniques.

Patients And Methods: The medical records of 414 consecutive patients who underwent neck clipping of unruptured intracranial aneurysms in our institution over a 5-year period were retrospectively reviewed. Clinical and neuroimaging variables were analyzed to investigate putative predictors of perioperative seizures using multivariate logistic regression analysis. Read More

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http://dx.doi.org/10.1016/j.clineuro.2019.02.007DOI Listing
February 2019

Cannabis for refractory epilepsy in children: A review focusing on CDKL5 Deficiency Disorder.

Epilepsy Res 2019 Feb 5;151:31-39. Epub 2019 Feb 5.

Telethon Kids Institute, University of Western Australia, Perth, WA, Australia(2). Electronic address:

Severe paediatric epilepsies such as CDKL5 Deficiency Disorder (CDD) are extremely debilitating, largely due to the early-onset and refractory nature of the seizures. Existing treatment options are often ineffective and associated with a host of adverse effects, causing those that are affected to seek alternative treatments. Cannabis based products have attracted significant attention over recent years, primarily driven by reports of miraculous cures and a renewed public preference for 'natural' therapies, thus placing intense pressure on health professionals and the government for regulatory change. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.02.001DOI Listing
February 2019

Predictors of epilepsy presentation in unruptured brain arteriovenous malformations: a quantitative evaluation of location and radiomics features on T2 weighted imaging.

World Neurosurg 2019 Feb 13. Epub 2019 Feb 13.

Departments of Interventional Neuroradiology, Beijing Neurosurgical Institute and Beijing Tiantan Hospital, Capital Medical University, Beijing, China. Electronic address:

Objective: To explore predictors of epilepsy presentation in unruptured bAVMs with quantitative evaluation of location and radiomics features on T2 weighted imaging.

Methods: This retrospective study identified 117 patients with unruptured bAVMs. Cases were randomly split into training (n=90) and test dataset (n=27). Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.229DOI Listing
February 2019

Antiepileptic therapy approaches in KCNQ2 related epilepsy: A systematic review.

Eur J Med Genet 2019 Feb 13. Epub 2019 Feb 13.

Division of Pediatric Neurology, Developmental Medicine and Social Pediatrics, Dr. von Haunersches Children's Hospital, LMU Munich, Lindwurmstraße4, 80337, Munich, Germany; Comprehensive Epilepsy Center for Children, Adolescents and Adults, LMU Munich, Lindwurmstraße 4, 80337, Munich, Germany. Electronic address:

Background: KCNQ2 related disorders comprise both benign seizure disorders and early onset epileptic encephalopathies. Especially within the latter group, patients suffer from refractory seizures to standard antiepileptic drugs and developmental delay. Besides the hope of personalized medical approaches to treat the recently unraveled large amount of genetic channelopathies, there are sparse systematic data on treatment responses in KCNQ2 related epilepsy in larger cohorts. Read More

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http://dx.doi.org/10.1016/j.ejmg.2019.02.001DOI Listing
February 2019

Validity of a rapid and simple fluorometric tripeptidyl peptidase 1 (TPP1) assay using dried blood specimens to diagnose CLN2 disease.

Clin Chim Acta 2019 Feb 13. Epub 2019 Feb 13.

Metabolic Laboratory, Center of Diagnostics, Hamburg, Germany; NCL Clinic, Department of Pediatrics, University Medical Center Eppendorf, Hamburg, Germany. Electronic address:

Purpose: CLN2 disease is a genetic disorder caused by dysfunction of the lysosomal enzyme tripeptidyl peptidase 1 (TPP1) that belongs to the neuronal ceroid lipofuscinoses (NCL) and leads to epilepsy, dementia, and death in young persons. CLN2 disease has recently become treatable by enzyme replacement, which can only be effective when the disease is diagnosed early. We have investigated the reliability of a test for TPP1 deficiency in dried blood specimens (DBS) to detect CLN2 disease. Read More

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http://dx.doi.org/10.1016/j.cca.2019.02.010DOI Listing
February 2019

Risk factors and control of seizures in 778 Chinese patients undergoing initial resection of supratentorial meningiomas.

Neurosurg Rev 2019 Feb 15. Epub 2019 Feb 15.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing, 100070, China.

This retrospective study explored the risk factors for the occurrence of seizures in the pre- and postoperative period in patients undergoing supratentorial meningiomas surgery to investigate those who are likely to benefit from prophylactic antiepileptic drugs (AEDs). We reviewed the medical records of 778 supratentorial meningiomas patients who were operated at our institution between 2011 and 2012. A total of 100 (12. Read More

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http://dx.doi.org/10.1007/s10143-019-01085-5DOI Listing
February 2019

Nightmare disorder and REM sleep behavior disorder in inflammatory arthritis: Possibility beyond neurodegeneration.

Brain Behav 2019 Feb 15:e01230. Epub 2019 Feb 15.

Department of Biomedical and NeuroMotor Sciences (DiBiNeM), University of Bologna, Bologna, Italy.

Objectives: To investigate the prevalence of REM sleep behavior disorder (RBD) in patients with inflammatory arthritis (IA) to ascertain if RBD could be an internal red flag signaling a fluctuating state of inflammation based on the theory of "protoconsciousness".

Materials & Methods: One hundred and three patients with a confirmed diagnosis of IA were consecutively recruited. The patients underwent general (IA activity, functional status, laboratory tests) and neurological evaluations. Read More

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http://dx.doi.org/10.1002/brb3.1230DOI Listing
February 2019

Indoleamine 2,3-dioxygenase 1 deletion promotes Theiler's virus-induced seizures in C57BL/6J mice.

Epilepsia 2019 Feb 15. Epub 2019 Feb 15.

Department of Animal Sciences, College of Agricultural, Consumer, and Environmental Sciences, Urbana, Illinois.

Objective: Viral encephalitis increases the risk for developing seizures and epilepsy. Indoleamine 2,3-dioxygenase 1 (Ido1) is induced by inflammatory cytokines and functions to metabolize tryptophan to kynurenine. Kynurenine can be further metabolized to produce kynurenic acid and the N-methyl-d-aspartate receptor agonist quinolinic acid (QuinA). Read More

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http://dx.doi.org/10.1111/epi.14675DOI Listing
February 2019

EEG and MEG source imaging for epilepsy surgery - A sobering 22-year interim report.

Authors:
Chris Plummer

Clin Neurophysiol 2019 Feb 10. Epub 2019 Feb 10.

Centre for Neurosciences and Neurological Research, St Vincent's Hospital, Melbourne, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.clinph.2019.02.001DOI Listing
February 2019

Inhibitory effects of glucagon-like peptide-1 receptor on epilepsy.

Biochem Biophys Res Commun 2019 Feb 12. Epub 2019 Feb 12.

Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Number 1, Youyi Road Yuzhong District, 400042, Chongqing, China. Electronic address:

Glucagon-like peptide-1 (GLP-1) and its receptor, GLP-1R, are valuable tools in the therapy of type 2 diabetes mellitus. Although GLP-1R stimulation is also potentially applicable to neurological disorders, few investigators have evaluated its beneficial effects in neurological disease models. Thus, we aimed to look into the antiepileptic effects of GLP-1R on epilepsy and its underlying mechanisms. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.02.028DOI Listing
February 2019

Music Therapy and Other Music-Based Interventions in Pediatric Health Care: An Overview.

Medicines (Basel) 2019 Feb 14;6(1). Epub 2019 Feb 14.

Department of Music Therapy, University of Music and Performing Arts Vienna, 1030 Vienna, Austria.

In pediatric health care, non-pharmacological interventions such as music therapy have promising potential to complement traditional medical treatment options in order to facilitate recovery and well-being. Music therapy and other music-based interventions are increasingly applied in the clinical treatment of children and adolescents in many countries world-wide. The purpose of this overview is to examine the evidence regarding the effectiveness of music therapy and other music-based interventions as applied in pediatric health care. Read More

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http://dx.doi.org/10.3390/medicines6010025DOI Listing
February 2019

Quality of life and psychological dysfunction in traumatized and nontraumatized patients with psychogenic nonepileptic seizures (PNES).

Epilepsy Behav 2019 Feb 12;92:341-344. Epub 2019 Feb 12.

CAPHRI School for Public Health and Primary Care, Department of Health Services Research, Maastricht University, Maastricht, the Netherlands; Centre for Economic Evaluation, Trimbos Institute, Netherlands Institute of Mental Health and Addiction, Utrecht, the Netherlands.

Objectives: Psychogenic nonepileptic seizures (PNES) have the appearance of epileptic seizures, yet show no epileptiform discharges in the brain. The quality of life (QOL) in patients with PNES is reportedly low and trauma eems to be a relevant risk factor. The objective of this study was to examine the difference between measures of (epilepsy-specific) QOL (Quality of Life in Epilepsy Inventory; QOLIE-31p) and psychological dysfunction (trauma symptom inventory; TSI) between patients with diagnosed PNES with self-reported trauma and those without self-reported trauma. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15255050183095
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http://dx.doi.org/10.1016/j.yebeh.2019.01.024DOI Listing
February 2019
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Lestaurtinib (CEP-701) modulates the effects of early life hypoxic seizures on cognitive and emotional behaviors in immature rats.

Epilepsy Behav 2019 Feb 12;92:332-340. Epub 2019 Feb 12.

Department of Anatomy, Cell biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut, Lebanon; Division of Child Neurology, Department of Pediatric and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon. Electronic address:

Hypoxic encephalopathy of the newborn is a major cause of long-term neurological sequelae. We have previously shown that CEP-701 (lestaurtinib), a drug with an established safety profile in children, attenuates short-term hyperexcitability and tropomyosin-related kinase B (TrkB) receptor activation in a well-established rat model of early life hypoxic seizures (HS). Here, we investigated the potential long-term neuroprotective effects of a post-HS transient CEP-701 treatment. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.01.023DOI Listing
February 2019

Widespread interictal epileptic discharge more likely than focal discharges to unveil the seizure onset zone in EEG-fMRI.

Clin Neurophysiol 2019 Jan 30;130(4):429-438. Epub 2019 Jan 30.

Montreal Neurological Institute and Hospital, McGill University, Canada.

Objective: We hypothesized that the number of interictal epileptic discharges (IEDs) during scan and their spatial extent are contributing factors in obtaining appropriate activations that reveal the seizure onset zone (SOZ) in EEG-fMRI.

Methods: 157 IED types, each corresponding to one EEG scalp distribution, in 64 consecutive EEG-fMRI studies from 64 patients with refractory localization-related epilepsy were reviewed. To determine reliable activation, we used the threshold corresponding to corrected whole-brain topological false discovery rate (FDR). Read More

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http://dx.doi.org/10.1016/j.clinph.2018.12.014DOI Listing
January 2019

Epileptic seizure detection using cross-bispectrum of electroencephalogram signal.

Seizure 2019 Feb 4;66:4-11. Epub 2019 Feb 4.

Hakim Sabzevari University, Sabzevar 397, Iran. Electronic address:

Purpose: The automatic detection of epileptic seizures in EEG data from extended recordings can make an important contribution to the diagnosis of epilepsy as it can efficiently reduce the workload of medical staff.

Methods: This paper describes how features based on cross-bispectrum can help with the detection of epileptic seizure activity in EEG data. Features were extracted from multi-channel intracranial EEG (iEEG) data from the Freiburg iEEG recordings of 21 patients with focal epilepsy. Read More

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http://dx.doi.org/10.1016/j.seizure.2019.02.001DOI Listing
February 2019

Chronic mild hypoxia promotes hippocampal neurogenesis involving Notch1 signaling in epileptic rats.

Brain Res 2019 Feb 12. Epub 2019 Feb 12.

Department of Neurology, Key Laboratory of Neurology of Hebei Province, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, People's Republic of China. Electronic address:

Cognitive impairment is one of the most common and disabling co-morbidities of epilepsy. It is therefore imperative to find novel treatment approaches to rescue cognitive function among epilepsy patients. Adult neurogenesis is strongly implicated in cognitive function, and mild hypoxia is known to promote the proliferation and differentiation of both embryonic and adult neural stem cells (NSCs). Read More

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http://dx.doi.org/10.1016/j.brainres.2019.02.011DOI Listing
February 2019

Neuroimmunology - The Past, Present and Future.

Clin Exp Immunol 2019 Feb 15. Epub 2019 Feb 15.

Department of Pathology, Amsterdam UMC, VUmc site, Amsterdam, The Netherlands.

Neuroimmunology as a separate discipline has its roots in the fields of neurology, neuroscience and immunology. Early studies of the brain by Golgi and Cajal, the detailed clinical and neuropathology studies of Charcot, and Thompson's seminal paper on graft acceptance in the central nervous system kindled a now rapidly expanding research area with the aim of understanding pathological mechanisms of inflammatory components of neurological disorders. Whilst neuroimmunologists originally focussed on classical neuroinflammatory disorders such as multiple sclerosis and infections, there is strong evidence to suggest that the immune response contributes to genetic white matter disorders, epilepsy, neurodegenerative diseases, neuropsychiatric disorders, peripheral nervous system and neuro-oncological conditions, as well as ageing. Read More

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http://doi.wiley.com/10.1111/cei.13279
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http://dx.doi.org/10.1111/cei.13279DOI Listing
February 2019
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Reduced resilience of brain gray matter networks in idiopathic generalized epilepsy: A graph-theoretical analysis.

PLoS One 2019 15;14(2):e0212494. Epub 2019 Feb 15.

Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, Tokyo, Japan.

Purpose: The pathophysiology of idiopathic generalized epilepsy (IGE) is still unclear, but graph theory may help to understand it. Here, we examined the graph-theoretical findings of the gray matter network in IGE using anatomical covariance methods.

Materials And Methods: We recruited 33 patients with IGE and 35 age- and sex-matched healthy controls. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212494PLOS
February 2019

ICU Survivors Have a Substantial Higher Risk of Developing New Chronic Conditions Compared to a Population-Based Control Group.

Crit Care Med 2019 Mar;47(3):324-330

National Intensive Care Evaluation (NICE) foundation, Amsterdam, The Netherlands.

Objectives: To describe the types and prevalence of chronic conditions in an ICU population and a population-based control group during the year before ICU admission and to quantify the risk of developing new chronic conditions in ICU patients compared with the control group.

Design: We conducted a retrospective cohort study, combining a national health insurance claims database and a national quality registry for ICUs. Claims data in the timeframe 2012-2014 were combined with clinical data of patients who had been admitted to an ICU during 2013. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003576DOI Listing

DEPDC5 mutation and familial focal epilepsy with variable foci: genotype and phenotype of a family.

Epileptic Disord 2019 Feb 15. Epub 2019 Feb 15.

Division of Neuropediatrics, Italian Hospital of Buenos Aires, CABA.

Familial focal epilepsy with variable foci is a relatively rare autosomal disease with an unclear incidence, which is characterized by focal seizures arising from different cortical regions in different family members. We describe three members of a two-generation Argentine family with familial focal epilepsy with variable foci syndrome and a DEPDC5 gene mutation. The mean onset age was nine years old. Read More

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http://dx.doi.org/10.1684/epd.2019.1025DOI Listing
February 2019

EEG of asymptomatic first-degree relatives of patients with juvenile myoclonic, childhood absence and rolandic epilepsy: a systematic review and meta-analysis.

Epileptic Disord 2019 Feb 15. Epub 2019 Feb 15.

Program in Genetics and Genome Biology, The Hospital for Sick Children, Institute of Medical Science, University of Toronto, Toronto, Division of Neurology, Department of Pediatrics, University of Texas Southwestern, Dallas, USA.

Rolandic (RE), childhood absence (CAE) and juvenile myoclonic (JME) epilepsy encompass centrotemporal sharp waves, 3-Hz spike waves and >3-Hz spike or polyspike waves, respectively. Evidence abounds for genetic roles in all three syndromes, yet involved genes for the vast majority of patients remain unknown. It has long been proposed that while each disease is genetically complex, its specific EEG trait may represent a genetically simpler endophenotype. Read More

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http://dx.doi.org/10.1684/epd.2019.1024DOI Listing
February 2019

Focal visual status epilepticus.

Epileptic Disord 2019 Feb 15. Epub 2019 Feb 15.

Department for Clinical Neurophysiology, University Medical Center Göttingen, Göttingen, Germany.

Epileptic visual auras are elementary to complex and sometimes occur as colourful visual phenomena located close to or within the central part of the contralateral hemi-field. They typically last from seconds to a few minutes, which discriminates them from the usually longer-lasting visual auras (5-30 minutes) of patients suffering from migraine. We present an adult patient with occipital lobe epilepsy whose visual aura under epilepsy monitoring lasted for more than 30 minutes with almost no propagation, demonstrating a rare, but remarkable, sustained local epileptic network activity associated with resection of an occipital arterio-venous malformation. Read More

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http://dx.doi.org/10.1684/epd.2019.1034DOI Listing
February 2019

Berardinelli-Seip syndrome and progressive myoclonus epilepsy.

Epileptic Disord 2019 Feb 15. Epub 2019 Feb 15.

Child Neurology and Psychiatry Unit, "Regina Montis Regalis" Hospital, Mondovì.

Berardinelli-Seip syndrome, or congenital generalized lipodystrophy type 2 (CGL2), is characterized by a lack of subcutaneous adipose tissue and precocious metabolic syndrome with insulin resistance, resulting in diabetes, dyslipidaemia, hepatic steatosis, cardiomyopathy, and acanthosis nigricans. Most reported mutations are associated with mild, non-progressive neurological impairment. We describe the clinical and EEG data of a patient with progressive myoclonus epilepsy (PME), CGL2, and progressive neurological impairment, carrying a homozygous BSCL2 nonsense mutation. Read More

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http://dx.doi.org/10.1684/epd.2019.1038DOI Listing
February 2019

A Rasmussen encephalitis, autoimmune encephalitis, and mitochondrial disease mimicker: expanding the DNM1L-associated intractable epilepsy and encephalopathy phenotype.

Epileptic Disord 2019 Feb 15. Epub 2019 Feb 15.

Department of Pediatric Epilepsy, Beaumont Health, Royal Oak, MI 48073.

Dynamin-1-like protein (DNM1L) gene variants have been linked to childhood refractory epilepsy, developmental delay, encephalopathy, microcephaly, and progressive diffuse cerebral atrophy. However, only a few cases have been reported in the literature and there is still a limited amount of information about the symptomatology and pathophysiology associated with pathogenic variants of DNM1L. We report a 10-year-old girl with a one-year history of mild learning disorder and absence seizures who presented with new-onset focal status epilepticus which progressed to severe encephalopathy and asymmetric hemispheric cerebral atrophy. Read More

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http://dx.doi.org/10.1684/epd.2019.1036DOI Listing
February 2019

Advancing health equity through cross-cutting approaches to health-related stigma.

BMC Med 2019 Feb 15;17(1):40. Epub 2019 Feb 15.

Uganda Youth Coalition on Adolescent Sexual Reproductive Health Rights and HIV, Kampala, Uganda.

Health-related stigma remains a major barrier to improving health and well-being for vulnerable populations around the world. This collection on stigma research and global health emerged largely as a result of a 2017 meeting on the "The Science of Stigma Reduction" sponsored by the US National Institutes of Health (NIH). An overwhelming consensus at the meeting was reached. Read More

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http://dx.doi.org/10.1186/s12916-019-1282-0DOI Listing
February 2019

Collaboration of Care for Women with Epilepsy in their Reproductive Years.

J Womens Health (Larchmt) 2019 Feb 15. Epub 2019 Feb 15.

2 New York University School of Medicine, New York, New York.

Over half a million women of childbearing age have epilepsy, many of which will require family planning care at some point in their reproductive years. Matters relating to contraception, pregnancy, fertility, and sexual functioning are all impacted to varying degrees by the use of antiepileptic drugs (AEDs) to treat epilepsy and require active management by a woman's neurologist. It is important that a woman's obstetrician/gynecologist (OBGYN) and internist are aware of the way in which their care may be related to her epilepsy care and how this can be successfully comanaged with her neurologist. Read More

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http://dx.doi.org/10.1089/jwh.2018.7506DOI Listing
February 2019

[Social representations of epilepsy and therapeutic routes of parents of epileptic children in Abidjan].

Sante Publique 2018 September October;30(5):703-712

Purpose: The present study examines the influence of representations of childhood epilepsies in their generalized form on the therapy courses of parents seeking treatment for their epileptic children.

Methods: The approach used is retrospective, quantitative and qualitative. The data collection was done through the analysis of the medical records of 81 children diagnosed with epilepsy and treated at the Abidjan Infant Guidance Center over a period of 18 months (January 2015 to June 2016), and a semi-directive interview administered to their parents who came with them for their medical follow-up. Read More

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http://dx.doi.org/10.3917/spub.186.0703DOI Listing
February 2019

New insights into human lysine degradation pathways with relevance to pyridoxine dependent epilepsy due to antiquitin deficiency.

J Inherit Metab Dis 2019 Feb 14. Epub 2019 Feb 14.

Division of Child Neurology, University Children's Hospital Zurich, Zurich, Switzerland.

Background: Deficiency of antiquitin (ATQ), an enzyme involved in lysine degradation, is the major cause of vitamin B dependent epilepsy. Accumulation of the potentially neurotoxic α-aminoadipic semialdehyde (AASA) may contribute to frequently associated developmental delay. AASA is formed by α-aminoadipic semialdehyde synthase (AASS) via the saccharopine pathway of lysine degradation, or, as has been postulated, by the pipecolic acid (PA) pathway, and then converted to α-aminoadipic acid (AAA) by ATQ. Read More

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http://dx.doi.org/10.1002/jimd.12076DOI Listing
February 2019

The effect of medial pulvinar stimulation on temporal lobe seizures.

Epilepsia 2019 Feb 14. Epub 2019 Feb 14.

Clinical Neurophysiology and Epileptology Department, Timone Hospital, Assitance Publique Hôpitaux de Marseille, Marseille, France.

We investigated the effect of electrical stimulation of the medial pulvinar (PuM) in terms of its effect on temporal lobe seizures. Eight patients with drug-resistant temporal lobe epilepsy undergoing stereoelectroencephalographic exploration were included. All had at least one electrode exploring the PuM. Read More

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http://dx.doi.org/10.1111/epi.14677DOI Listing
February 2019

A case of ictal burst-suppression.

Epilepsy Behav Case Rep 2019 26;11:73-76. Epub 2018 Nov 26.

Department of Neurology, University of Tennessee Health Science Center, TN, USA.

"Burst-suppression" pattern consists of complete attenuation of background between bursts of mixed frequencies, variable morphology and waveforms. It is a subgroup of periodic patterns seen in severe cerebral damage, anesthesia or prematurity. Here, we present a 46-year-old woman with post-anoxic encephalopathy on cooling protocol with two electrographically similar patterns of burst-suppression (one with a clinical ictal correlate of isolated eye movements), as well as three electroclinical seizures. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22133232183010
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http://dx.doi.org/10.1016/j.ebcr.2018.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360329PMC
November 2018
1 Read

Self-Management in Epilepsy Care: Untapped Opportunities.

Fed Pract 2018 Apr;35(Suppl 3):S10-S16

is a Nurse Practitioner at the Epilepsy Center of Excellence VA Puget Sound Health Care System in Seattle, Washington. is Regional Administrative Director, Southeast Epilepsy Centers of Excellence, Durham VAMC in North Carolina and an Assistant Professor at Liberty University in Lynchburg, Virginia. is the Director at the Epilepsy Centers of Excellence at Hunter Holmes McGuire Veterans Administration Medical Center and Professor at Virginia Commonwealth University, both in Richmond. is an Associate Professor at University of California, San Francisco and a Staff Physician at the Epilepsy Center of Excellence at the San Francisco VA Medical Center in California.

Constant accessibility, rapid scalability, and modest costs make digital and mobile epilepsy self-management platforms an attractive alternative to resource-intensive in-person programs. Read More

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Nonadherence to Antiepileptic Medications: Still a Major Issue to be Addressed in the Management of Epilepsy.

J Neurosci Rural Pract 2019 Jan-Mar;10(1):106-112

Department of Neurology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam 34212, Kingdom of Saudi Arabia.

Context: Medication nonadherence is a significant barrier in achieving seizure freedom in patients with epilepsy. There is a deficiency of data about the reasons for nonadherence in Saudi population.

Aims: The aim of this study is to prove the existence of nonadherence to antiepileptic drugs (AEDs) in patients with epilepsy and identify the responsible factors. Read More

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http://dx.doi.org/10.4103/jnrp.jnrp_136_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337980PMC
February 2019

Regional specificity of cortico-thalamic coupling strength and directionality during waxing and waning of spike and wave discharges.

Sci Rep 2019 Feb 14;9(1):2100. Epub 2019 Feb 14.

Institute of Physiology I, Westfälische Wilhelms-Universität Münster, Münster, Germany.

Spike-wave discharges (SWDs) on the EEG during absence epilepsy are waxing and waning stages of corticothalamic hypersynchrony. While the somatosensory cortex contains an epileptic focus, the role of thalamic nuclei in SWD generation is debated. Here we assess the contribution of distinct thalamic nuclei through multiple-site unit recordings in a genetic rat model of absence epilepsy and cross-correlation analysis, revealing coupling strength and directionality of neuronal activity at high temporal resolution. Read More

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http://dx.doi.org/10.1038/s41598-018-37985-7DOI Listing
February 2019

Pins and PNES: Systematic content analysis of Pinterest for information on psychogenic nonepileptic seizures (PNES).

Epilepsy Behav 2019 Feb 11. Epub 2019 Feb 11.

Department of Psychiatry, Cleveland Clinic, United States of America.

Pinterest is a visual search based, the fourth largest social networking site in the U.S. with 81% of its users being women. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.01.020DOI Listing
February 2019

Syncope after administration of epidural analgesia in an obstetric patient with a vagus nerve stimulator.

Authors:
J E Tang J B Hyman

Int J Obstet Anesth 2019 Jan 6. Epub 2019 Jan 6.

Department of Anesthesiology, Perioperative and Pain Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place Box 1010, New York, NY 10029, United States. Electronic address:

Vagus nerve stimulation (VNS) is an adjunctive therapy for medically refractory epilepsy and depression. Vagus nerve stimulation is generally well-tolerated, but cardiac arrhythmias or asystole are rare complications that have been reported. This case report describes an obstetric patient who received epidural analgesia and subsequently experienced two episodes of syncope synchronous with stimulation from her VNS device. Read More

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http://dx.doi.org/10.1016/j.ijoa.2018.12.011DOI Listing
January 2019

The Health Stigma and Discrimination Framework: a global, crosscutting framework to inform research, intervention development, and policy on health-related stigmas.

BMC Med 2019 Feb 15;17(1):31. Epub 2019 Feb 15.

Yale University, New Haven, CT, USA.

Stigma is a well-documented barrier to health seeking behavior, engagement in care and adherence to treatment across a range of health conditions globally. In order to halt the stigmatization process and mitigate the harmful consequences of health-related stigma (i.e. Read More

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http://dx.doi.org/10.1186/s12916-019-1271-3DOI Listing
February 2019

A scoping review of health-related stigma outcomes for high-burden diseases in low- and middle-income countries.

BMC Med 2019 Feb 15;17(1):17. Epub 2019 Feb 15.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD, 21205, USA.

Background: Stigma is associated with health conditions that drive disease burden in low- and middle-income countries (LMICs), including HIV, tuberculosis, mental health problems, epilepsy, and substance use disorders. However, the literature discussing the relationship between stigma and health outcomes is largely fragmented within disease-specific siloes, thus limiting the identification of common moderators or mechanisms through which stigma potentiates adverse health outcomes as well as the development of broadly relevant stigma mitigation interventions.

Methods: We conducted a scoping review to provide a critical overview of the breadth of research on stigma for each of the five aforementioned conditions in LMICs, including their methodological strengths and limitations. Read More

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http://dx.doi.org/10.1186/s12916-019-1250-8DOI Listing
February 2019

Pediatric Epilepsy Mechanisms: Expanding the Paradigm of Excitation/Inhibition Imbalance.

Children (Basel) 2019 Feb 5;6(2). Epub 2019 Feb 5.

Division of Pediatric Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

Mechanisms underlying seizures and epilepsy have traditionally been considered to involve abnormalities of ion channels or synaptic function. Those considerations gave rise to the excitation/inhibition (E/I) imbalance theory, whereby increased excitation, decreased inhibition, or both favor a hyperexcitable state and an increased propensity for seizure generation and epileptogenesis. Several recent findings warrant reconsideration and expansion of the E/I hypothesis: novel genetic mutations have been identified that do not overtly affect E/I balance; neurotransmitters may exert paradoxical effects, especially during development; anti-seizure medications do not necessarily work by decreasing excitation or increasing inhibition; and metabolic factors participate in the regulation of neuronal and network excitability. Read More

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http://dx.doi.org/10.3390/children6020023DOI Listing
February 2019

HLA-G allelic distribution in Sardinian children with Autism spectrum disorders: A replication study.

Brain Behav Immun 2019 Feb 11. Epub 2019 Feb 11.

IRCCS Fondazione Don Carlo Gnocchi, Milano, Italy; Pathophysiology and Transplantation, University of Milano, Milano, Italy.

Recent results show that in mainland Italian children with Autism spectrum disorder (ASD), HLA-G coding alleles distribution is skewed and an association between HLA-G*01:05N and ASD is present. Herein, in an independent cohort of Sardinian ASD (sASD) children and their relatives, we verify whether HLA-G allele association with ASD could be confirmed in this genetically peculiar insular population. One hundred children with a diagnosis of ASD, born in Sardinia and of Sardinian descent, 91 of their mothers, and 40 of their healthy siblings were enrolled. Read More

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http://dx.doi.org/10.1016/j.bbi.2019.02.003DOI Listing
February 2019

Etiology, seizure type, and prognosis of epileptic seizures in the emergency department.

Epilepsy Behav 2019 Feb 11;92:327-331. Epub 2019 Feb 11.

Epilepsy Unit, Neurology Department, Vall d'Hebron Hospital, Passeig Vall d'Hebron 119-121, 08035 Barcelona, Spain. Electronic address:

Epileptic seizures are a common reason for emergency department (ED) admittance. We aimed to describe the etiological distribution of epileptic seizures and the relationships between etiology and semiology in patients admitted to the emergency room, and to identify early prognostic factors for recurrence and mortality.

Methods: A retrospective observational study was conducted in adult patients consecutively attended in the emergency room with epileptic seizures over a 2-year period. Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.12.008DOI Listing
February 2019

The analysis of risk factors and survival outcome for Chinese high-grade glioma patients with epilepsy.

World Neurosurg 2019 Feb 11. Epub 2019 Feb 11.

Glioma Surgery Division, Neurological Surgery Department of Huashan Hospital, Fudan University, Shanghai, 200040, China. Electronic address:

Objective: To evaluate the risk factors of tumor related epilepsy (TRE) and the relationship between TRE and functional/survival outcomes in high-grade glioma (HGG) patients.

Method: The clinical data of 587 patients with HGG were retrospectively analyzed. Chi-square test and logistic multiple regression analysis were used to analyze factors associated with TRE. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193032
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http://dx.doi.org/10.1016/j.wneu.2019.01.213DOI Listing
February 2019
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Suppressing pro-inflammatory prostaglandin signaling attenuates excitotoxicity-associated neuronal inflammation and injury.

Neuropharmacology 2019 Feb 11. Epub 2019 Feb 11.

DepartmenSt of Pharmacology and Chemical Biology, School of Medicine, Emory University, Atlanta, GA, USA.

Glutamate receptor-mediated excitotoxicity is a common pathogenic process in many neurological conditions including epilepsy. Prolonged seizures induce elevations in extracellular glutamate that contribute to excitotoxic damage, which in turn can trigger chronic neuroinflammatory reactions, leading to secondary damage to the brain. Blocking key inflammatory pathways could prevent such secondary brain injury following the initial excitotoxic insults. Read More

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http://dx.doi.org/10.1016/j.neuropharm.2019.02.011DOI Listing
February 2019

Role of DAPK1 in neuronal cell death, survival and diseases in the nervous system.

Int J Dev Neurosci 2019 Feb 11. Epub 2019 Feb 11.

Department of Biology, College of Sciences, United Arab Emirates University, Al Ain, P.O. Box 17551, United Arab Emirates. Electronic address:

DAPK (death-associated protein kinase) is a calcium/calmodulin (Ca2+/CaM) regulated serine/threonine kinase. Structurally, it assumes a multi-domain structure and participates in various apoptotic systems which imply that it may interact with a wide range of intracellular components to exert its action. DAPK plays vital roles in pro-apoptotic, apoptotic and autophagic pathways. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07365748183027
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http://dx.doi.org/10.1016/j.ijdevneu.2019.02.003DOI Listing
February 2019
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Targeted resequencing of 358 candidate genes for autism spectrum disorder in a Chinese cohort reveals diagnostic potential and genotype-phenotype correlations.

Hum Mutat 2019 Feb 14. Epub 2019 Feb 14.

Center for Bioinformatics, State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, China.

Autism spectrum disorder (ASD) is a childhood neuropsychiatric disorder with a complex genetic architecture. The diagnostic potential of a targeted panel of ASD genes has only been evaluated in small cohorts to date and is especially understudied in the Chinese population. Here, we designed a capture panel with 358 genes (111 syndromic and 247 non-syndromic) for ASD and sequenced a Chinese cohort of 539 cases evaluated with the Autism Diagnostic Interview-Revised (ADI-R) and the Autism Diagnostic Observation Schedule (ADOS) as well as 512 controls. Read More

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http://dx.doi.org/10.1002/humu.23724DOI Listing
February 2019

Community-, facility-, and individual-level outcomes of a district mental healthcare plan in a low-resource setting in Nepal: A population-based evaluation.

PLoS Med 2019 Feb 14;16(2):e1002748. Epub 2019 Feb 14.

Centre for Global Mental Health, Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.

Background: In low-income countries, care for people with mental, neurological, and substance use (MNS) disorders is largely absent, especially in rural settings. To increase treatment coverage, integration of mental health services into community and primary healthcare settings is recommended. While this strategy is being rolled out globally, rigorous evaluation of outcomes at each stage of the service delivery pathway from detection to treatment initiation to individual outcomes of care has been missing. Read More

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http://dx.doi.org/10.1371/journal.pmed.1002748DOI Listing
February 2019

Potential public health benefits from cat eradications on islands.

PLoS Negl Trop Dis 2019 Feb 14;13(2):e0007040. Epub 2019 Feb 14.

Department of Ecology and Evolutionary Biology, University of California Santa Cruz, Santa Cruz, California, United States of America.

Cats (Felis catus) are reservoirs of several pathogens that affect humans, including Toxoplasma gondii. Infection of pregnant women with T. gondii can cause ocular and neurological lesions in newborns, and congenital toxoplasmosis has been associated with schizophrenia, epilepsy, movement disorders, and Alzheimer's disease. Read More

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http://dx.plos.org/10.1371/journal.pntd.0007040
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http://dx.doi.org/10.1371/journal.pntd.0007040DOI Listing
February 2019
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