143,266 results match your criteria Epilepsy & Behavior[Journal]


Using Artificial Intelligence to Identify Factors Associated with Autism Spectrum Disorder in Adolescents with Cerebral Palsy.

Neuropediatrics 2019 Apr 24. Epub 2019 Apr 24.

Department of Pediatric Orthopaedic Surgery, Lenval University Pediatric Hospital of Nice, Nice, France.

Autism spectrum disorder (ASD) is common in adolescents with cerebral palsy (CP) and there is a lack of studies applying artificial intelligence to investigate this field and this population in particular. The aim of this study is to develop and test a predictive learning model to identify factors associated with ASD in adolescents with CP. This was a multicenter controlled cohort study of 102 adolescents with CP (61 males, 41 females; mean age ± SD [standard deviation] = 16. Read More

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http://dx.doi.org/10.1055/s-0039-1685525DOI Listing

Downregulation of microRNA-200c-3p reduces damage of hippocampal neurons in epileptic rats by upregulating expression of RECK and inactivating the AKT signaling pathway.

Chem Biol Interact 2019 Apr 21. Epub 2019 Apr 21.

Department of Pediatrics, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, PR China.

Objective: The aim of this study is to investigate the role of mircoRNA-200c-3p (miR-200c-3p) on hippocampal neuron injury in epileptic rats through the regulation of the AKT signaling pathway by targeting RECK.

Methods: The epilepsy rat model was induced by intraperitoneal injection of lithium chloride-pilocarpine. Successful modeled rats were injected with miR-200c-3p inhibitors, inhibitors NC, siRNA-negative control (NC) and RECK-siRNA. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.04.027DOI Listing

Genetic Etiologies, Diagnosis, and Treatment of Tuberous Sclerosis Complex.

Annu Rev Genomics Hum Genet 2019 Apr 24. Epub 2019 Apr 24.

F.M. Kirby Neurobiology Center, Translational Neuroscience Center, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA; email:

Tuberous sclerosis complex (TSC) is an autosomal dominant disorder that affects multiple organ systems due to an inactivating variant in either or , resulting in the hyperactivation of the mechanistic target of rapamycin (mTOR) pathway. Dysregulated mTOR signaling results in increased cell growth and proliferation. Clinically, TSC patients exhibit great phenotypic variability, but the neurologic and neuropsychiatric manifestations of the disease have the greatest morbidity and mortality. Read More

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http://dx.doi.org/10.1146/annurev-genom-083118-015354DOI Listing

Childhood epilepsy with a small number of seizures may be left untreated: an international prospective study.

Epileptic Disord 2019 Apr;21(2):141-153

Department of Paediatrics, Dalhousie University and the IWK Health Centre, Halifax, Nova Scotia, Canada.

It is unknown whether treatment with antiepileptic drugs in children with epilepsy with a presumed good prognosis is always necessary. We aimed to study the course of newly diagnosed epilepsy in children with a presumed good prognosis who are managed without AED treatment. A total of 151 children (one month to 12 years of age) with two to five lifetime unprovoked seizures (excluding febrile convulsions), were followed for three years. Read More

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http://dx.doi.org/10.1684/epd.2019.1040DOI Listing

Stiripentol for the treatment of seizures in Dravet syndrome.

Expert Rev Clin Pharmacol 2019 Apr 24:1-10. Epub 2019 Apr 24.

a University of Colorado Denver Anschutz School of Medicine , Children's Hospital Colorado , Aurora , CO , USA.

Introduction: Dravet syndrome is an early childhood-onset epilepsy syndrome characterized by drug-resistant seizures, frequent episodes of status epilepticus, and the development of neurocognitive impairment. Seizure freedom in this condition is rare and there is a higher rate of sudden unexplained death in epilepsy patients (SUDEP) than other epilepsy syndromes. Stiripentol is a recently approved medication with an indication specifically for the treatment of seizures in children with Dravet syndrome. Read More

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http://dx.doi.org/10.1080/17512433.2019.1605904DOI Listing

[Epilepsy surgery for refractory neurocysticercosis-related epilepsy].

Rev Neurol 2019 May;68(9):384-388

Western University, London, Ontario, Canada.

Introduction: Neurocysticercosis is one of the most frequent causes of epilepsy worldwide, with some cases going into refractoriness. For that reason, surgical treatment should be considered, particularly lesionectomy, with or without temporal lobectomy.

Case Reports: From our series of patients with drug-resistant epilepsy from 2008 to 2018, we selected all cases with one or more lesions suggestive of neurocysticercosis who underwent epilepsy surgery. Read More

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http://dx.doi.org/10.33588/rn.6809.2018354DOI Listing

Asthma phenotypes and associated comorbidities in a large cohort of adolescents in Israel.

J Asthma 2019 Apr 24:1-14. Epub 2019 Apr 24.

a Medical Corps, IDF , Israel.

Objectives: Asthma is a multifactorial, heterogeneous, complex and common chronic respiratory disease driven by diverse mechanisms. Although asthma presents various clinical forms with different levels of severity, it is unclear whether asthma severities are a consequence of disease management or varied etiologies. We sought to investigate this question. Read More

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http://dx.doi.org/10.1080/02770903.2019.1604743DOI Listing

Focal stimulation of the sheep motor cortex with a chronically implanted minimally invasive electrode array mounted on an endovascular stent.

Nat Biomed Eng 2018 Dec 3;2(12):907-914. Epub 2018 Dec 3.

Vascular Bionics Laboratory, Department of Medicine (Royal Melbourne Hospital), University of Melbourne, Parkville, Victoria, Australia.

Direct electrical stimulation of the brain can alleviate symptoms associated with Parkinson's disease, depression, epilepsy and other neurological disorders. However, access to the brain requires invasive procedures, such as the removal of a portion of the skull or the drilling of a burr hole. Also, electrode implantation into tissue can cause inflammatory tissue responses and brain trauma, and lead to device failure. Read More

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http://dx.doi.org/10.1038/s41551-018-0321-zDOI Listing
December 2018

Impaired cortico-striatal excitatory transmission triggers epilepsy.

Nat Commun 2019 Apr 23;10(1):1917. Epub 2019 Apr 23.

Laboratory for Neurogenetics, RIKEN Center for Brain Science, Wako, Saitama, 351-0198, Japan.

STXBP1 and SCN2A gene mutations are observed in patients with epilepsies, although the circuit basis remains elusive. Here, we show that mice with haplodeficiency for these genes exhibit absence seizures with spike-and-wave discharges (SWDs) initiated by reduced cortical excitatory transmission into the striatum. Mice deficient for Stxbp1 or Scn2a in cortico-striatal but not cortico-thalamic neurons reproduce SWDs. Read More

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http://dx.doi.org/10.1038/s41467-019-09954-9DOI Listing

SIRT3 mediates hippocampal synaptic adaptations to intermittent fasting and ameliorates deficits in APP mutant mice.

Nat Commun 2019 Apr 23;10(1):1886. Epub 2019 Apr 23.

Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD, 21224, USA.

Intermittent food deprivation (fasting, IF) improves mood and cognition and protects neurons against excitotoxic degeneration in animal models of epilepsy and Alzheimer's disease (AD). The mechanisms by which neuronal networks adapt to IF and how such adaptations impact neuropathological processes are unknown. We show that hippocampal neuronal networks adapt to IF by enhancing GABAergic tone, which is associated with reduced anxiety-like behaviors and improved hippocampus-dependent memory. Read More

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http://www.nature.com/articles/s41467-019-09897-1
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http://dx.doi.org/10.1038/s41467-019-09897-1DOI Listing
April 2019
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Antagonizing increased miR-135a levels at the chronic stage of experimental TLE reduces spontaneous recurrent seizures.

J Neurosci 2019 Apr 23. Epub 2019 Apr 23.

Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, 3584 CG Utrecht, The Netherlands.

Mesial Temporal Lobe Epilepsy (mTLE) is a chronic neurological disease characterized by recurrent seizures. The anti-epileptic drugs currently available to treat mTLE are ineffective in one-third of patients and lack disease-modifying effects. MicroRNAs (miRNAs), a class of small non-coding RNAs which control gene expression at the post-transcriptional level, play a key role in the pathogenesis of mTLE and other epilepsies. Read More

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http://dx.doi.org/10.1523/JNEUROSCI.3014-18.2019DOI Listing

A small molecular compound selectively activates K2P channel TASK-3 by acting at two distant clusters of residues.

Mol Pharmacol 2019 Apr 23. Epub 2019 Apr 23.

Shanghai Institute of Materia Medica, Chinese Academy of Sciences;

TASK-3 channel is a member of the K2P family that important for the maintenance of the resting membrane potential. Previous studies have demonstrated that TASK-3 channel was involved in several physiological and pathological processes including sleep/wake control, cognition and epilepsy. However, there is still a lack of selective pharmacological tools of TASK-3 currently, which limits the further research of channel function. Read More

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http://dx.doi.org/10.1124/mol.118.115303DOI Listing

Abnormal visual sensitivity in eyelid myoclonia with absences: Evidence from electrocortical connectivity and non-linear quantitative analysis of EEG signal.

Seizure 2019 Apr 10;69:118-124. Epub 2019 Apr 10.

Department "G.F. Ingrassia", Section of Neurosciences, University of Catania, Via S. Sofia 78, 95123 Catania, Italy. Electronic address:

Purpose: Eyelid myoclonia with absences (EMA) is an epileptic syndrome characterized by eyelid myoclonia with or without absences, eyes closure-induced EEG paroxysms and photosensitivity. Pathophysiological mechanisms of visual sensitivity in EMA are not-fully understood. The objective of the present study was to analyze the electrophysiological dynamics implicated in the visual sensitivity in patients with EMA. Read More

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http://dx.doi.org/10.1016/j.seizure.2019.04.007DOI Listing

Nose-to-brain delivery of levetiracetam after intranasal administration to mice.

Int J Pharm 2019 Apr 20. Epub 2019 Apr 20.

Laboratory of Pharmacology, Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal; CIBIT - Coimbra Institute for Biomedical Imaging and Translational Research, University of Coimbra, Coimbra, Portugal. Electronic address:

Despite being one of the most commonly prescribed antiepileptic drugs, levetiracetam is marketed in oral and intravenous dosage forms, which are associated to drug-drug interactions and drug-resistant epilepsy (DRE). The purpose of the present study was to assess the potential of the intranasal route to deliver levetiracetam into the brain, due to the particular anatomical features of the nasal cavity. After development and characterization of the drug formulation, a thermoreversible gel loaded with levetiracetam was administered to CD-1 male mice by intranasal route and its pharmacokinetics compared to those observed after intravenous administration. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.04.047DOI Listing

[Clinical and imaging features of cerebral infarction in children].

Zhongguo Dang Dai Er Ke Za Zhi 2019 Apr;21(4):354-358

Department of Radiology, Shengjing Hospital of China Medical University, Shenyang 110004, China.

Objective: To summarize and analyze the etiology, clinical manifestations and imaging features of children with cerebral infarction.

Methods: A retrospective analysis was performed for the clinical data of 54 children with cerebral infarction, including etiology, clinical manifestations, distribution of infarcts, type of infarcts and clinical outcome.

Results: Of the 54 children, 93% had a clear cause, among whom 46% had the coexistence of multiple factors, and the top three causes were infection (54%), vascular disease (40%) and trauma (26%). Read More

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[A clinical analysis of electrical status epilepticus during sleep in children and a follow-up study of methylprednisolone pulse therapy].

Zhongguo Dang Dai Er Ke Za Zhi 2019 Apr;21(4):348-353

Department of Pediatrics, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221000, China.

Objective: To study the clinical features of electrical status epilepticus during sleep (ESES) in children, as well as the clinical effect of methylprednisolone pulse therapy in children with ESES.

Methods: A retrospective analysis was performed using the clinical data of 78 children with ESES. Among these children, 56 children who had had the failure of antiepileptic drugs were treated with methylprednisolone pulse therapy at a dose of 15-20 mg/(kg·d) for three courses. Read More

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Clinical Presentation and Outcome in Autoimmune Encephalitis Associated With N-Type Voltage-Gated Calcium Channels in Children.

J Child Neurol 2019 Apr 23:883073819840448. Epub 2019 Apr 23.

3 Northeast Epilepsy Group, Hackensack, NJ, USA.

Objective: We present the diagnostic and clinical course of the first multicenter case series of pediatric patients with autoimmune encephalitis associated with N-type voltage-gated calcium channel antibodies.

Methods: Data from 2 university hospitals were retrospectively reviewed and records of 3 patients with autoimmune encephalitis associated with N-type voltage-gated calcium channel antibodies were evaluated.

Results: The 3 pediatric patients (all female) had symptoms that spanned the clinical spectrum. Read More

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http://dx.doi.org/10.1177/0883073819840448DOI Listing

The incremental value of neuropsychological assessment: a critical review.

Authors:
Jacobus Donders

Clin Neuropsychol 2019 Apr 23:1-32. Epub 2019 Apr 23.

a Department of Psychology , Mary Free Bed Rehabilitation Hospital , Grand Rapids , MI , USA.

Objective: The purpose of this critical review was to evaluate the current state of research regarding the incremental value of neuropsychological assessment in clinical practice, above and beyond what can be accounted for on the basis of demographic, medical, and other diagnostic variables. The focus was on neurological and other medical conditions across the lifespan where there is known risk for presence or future development of cognitive impairment.

Method: Eligible investigations were group studies that had been published after 01/01/2000 in English in peer-reviewed journals and that had used standardized neuropsychological measures and reported on objective outcome criterion variables. Read More

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http://dx.doi.org/10.1080/13854046.2019.1575471DOI Listing

Use of Cannabidiol in the Treatment of Epilepsy: Efficacy and Security in Clinical Trials.

Molecules 2019 Apr 12;24(8). Epub 2019 Apr 12.

IRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy.

Cannabidiol (CBD) is one of the cannabinoids with non-psychotropic action, extracted from . CBD is a terpenophenol and it has received a great scientific interest thanks to its medical applications. This compound showed efficacy as anti-seizure, antipsychotic, neuroprotective, antidepressant and anxiolytic. Read More

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http://dx.doi.org/10.3390/molecules24081459DOI Listing

Assessment of cognitive profile as a prodromal marker of the evolution of REM sleep Behavior Disorder.

Sleep 2019 Apr 23. Epub 2019 Apr 23.

Unit of Sleep Medicine and Epilepsy, IRCCS Mondino Foundation, Pavia, Italy.

Study Objectives: To search for a specific neuropsychological profile in idiopathic REM sleep Behavior Disorder (iRBD), able to predict the onset of neurodegenerative disorders.

Methods: In a longitudinal follow-up study of 63 consecutive iRBD patients (follow-up duration 6.7± 3. Read More

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http://dx.doi.org/10.1093/sleep/zsz103DOI Listing

Evidence of a Clinically Significant Drug-Drug Interaction between Cannabidiol and Tacrolimus.

Am J Transplant 2019 Apr 23. Epub 2019 Apr 23.

Division of Nephrology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

Cannabidiol (CBD), a major purified non-psychoactive component of cannabis with anticonvulsant properties, was approved by the Food and Drug Administration in June 2018 as an adjuvant treatment for refractory epilepsy (Epidiolex; GW Pharmaceuticals). CBD is metabolized by CYP3A4 and CYP2C19 with a growing body of evidence suggesting it is also a potent inhibitor of these pathways. We report for the first time a significant drug-drug interaction between the purified CBD product and tacrolimus. Read More

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http://dx.doi.org/10.1111/ajt.15398DOI Listing

Sleepwalking and Sleep Paralysis: Prevalence in Colombian Families With Genetic Generalized Epilepsy.

J Child Neurol 2019 Apr 23:883073819842422. Epub 2019 Apr 23.

1 Grupo Mapeo Genético, Facultad de Medicina, Universidad de Antioquia, Medellin-Colombia.

Background: Sleep deprivation commonly increases seizure frequency in patients with genetic generalized epilepsy, though it is unknown whether there is an increased prevalence of sleepwalking or sleep paralysis in genetic generalized epilepsy patients. Establishing this could provide insights into the bio-mechanisms or genetic architecture of both disorders. The aim of this study was to determine the prevalence of sleepwalking and sleep paralysis in a cohort of patients with genetic generalized epilepsy and their relatives in extended families. Read More

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http://dx.doi.org/10.1177/0883073819842422DOI Listing

Treatment Works, So Who's Afraid of PNES?

Authors:
Jay Salpekar

Epilepsy Curr 2019 Mar-Apr;19(2):1535759719841354

Adherence With Psychotherapy and Treatment Outcomes for Psychogenic Nonepileptic Seizures Tolchin B, Dworetzky BA, Martino S, et al. Neurology. 2019;92(7):e675-e679. Read More

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http://dx.doi.org/10.1177/1535759719841354DOI Listing

High-Frequency Activity During Stereotyped Low-Frequency Events Might Help to Identify the Seizure Onset Zone.

Epilepsy Curr 2019 Mar-Apr;19(2):1535759719842236

Stereotyped high-frequency oscillations discriminate seizure onset zones and critical functional cortex in focal epilepsy. Liu S, Gurses C, Sha Z, Quach MM, Sencer A, Bebek N, et al. Brain. Read More

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http://dx.doi.org/10.1177/1535759719842236DOI Listing

Concomitance of benign epilepsy with centrotemporal spikes and childhood absence epilepsy: an unusual case.

Neurol Sci 2019 Apr 23. Epub 2019 Apr 23.

Department of Internal Medicine, Sanggye Paik Hospital, College of Medicine, Inje University, Seoul, Republic of Korea.

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http://dx.doi.org/10.1007/s10072-019-03893-5DOI Listing

Correlation between EEG during AED withdrawal and epilepsy recurrence: a meta-analysis.

Neurol Sci 2019 Apr 22. Epub 2019 Apr 22.

Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.

To assess the risk of epilepsy recurrence after withdrawal from antiepileptic drugs (AEDs), researchers extensively studied recurrence-related risk factors, including electroencephalogram (EEG) during AED withdrawal. The relationship between EEG and epilepsy recurrence is controversial. We used meta-analysis to determine the correlation between EEG during AED withdrawal and epilepsy recurrence. Read More

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http://dx.doi.org/10.1007/s10072-019-03855-xDOI Listing

Risk factors associated with epilepsy development in children with cerebral palsy.

Childs Nerv Syst 2019 Apr 22. Epub 2019 Apr 22.

Cerrahpasa Faculty of Medicine, Department of Pediatric Neurology, Istanbul University, Istanbul, Turkey.

Objectives: Epilepsy is one of the most common and important comorbidity among patients with cerebral palsy (CP). The purpose of this study was to determine the risk factors predicting the development of epilepsy considering prenatal, perinatal, and natal characteristics; associated impairments; and cranial imaging findings in our patient population with cerebral palsy at a tertiary center in Istanbul, Turkey.

Methods: This retrospective study consisted of 234 children aged between 3 and 18 years of age. Read More

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http://link.springer.com/10.1007/s00381-019-04152-w
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http://dx.doi.org/10.1007/s00381-019-04152-wDOI Listing
April 2019
1 Read

Familial association of genetic generalised epilepsy with limb-girdle muscular dystrophy through a mutation in .

Epilepsy Behav Case Rep 2019 21;11:122-124. Epub 2019 Mar 21.

Hospital Clínico Universitario Lozano Blesa, Avda. San Juan Bosco 15, 50009 Zaragoza, Spain.

•We present a family that includes members with phenotypes of generalized epilepsy and limb-girdle muscular dystrophy.•Subjects with heterozygous mutation developed epilepsy; a subject with homozygous mutation developed limb-girdle dystrophy.•Mutations in CAPN3 may play a role in the complex genetics of genetic generalized epilepsies. Read More

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http://dx.doi.org/10.1016/j.ebcr.2019.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460322PMC

Asymptomatic carotid acute dissection following focal status epilepticus.

Epilepsy Behav Case Rep 2019 17;11:120-121. Epub 2019 Mar 17.

Department of Neuroscience, Imaging and Clinical Sciences, University G. d'Annunzio of Chieti-Pescara, Italy.

•CAD is one of the most important predisposing factors of cerebral ischaemia in young adults.•Focal motor seizures with the involvement of the neck may represent a risk condition of developing CAD•A heightened awareness for CAD should be recommended in patients affected by epilepsy, carotid dopplers may confirm the clinical suspicion in case of significant neck trauma associated with seizures. Read More

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http://dx.doi.org/10.1016/j.ebcr.2019.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460323PMC

Anticonvulsant Effects of Dingxian Pill in Pentylenetetrazol-Kindled Rats.

Evid Based Complement Alternat Med 2019 18;2019:4534167. Epub 2019 Mar 18.

Central Laboratory, Department of Neurology and Neurosurgery, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Dingxian pill has been used as an antiepilepsy agent in China from ancient to modern times, of which the concrete pharmacological characterization and the underlying molecular mechanism remain unclear. The present study was undertaken to investigate them by animal behavior, electroencephalogram (EEG), Morris water maze, immunohistochemistry, transcriptomics, and real-time PCR. In our results, the treatment of Dingxian pill dose-dependently inhibited PTZ-induced seizure-like behavior and reduced the seizure grades, LFP power spectral density, and brain wave of the epileptiform EEG component induced by PTZ. Read More

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http://dx.doi.org/10.1155/2019/4534167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442303PMC

Threshold for maximal electroshock seizures (MEST) at three developmental stages in young mice.

Zool Res 2019 May 28;40(3):231-235. Epub 2019 Mar 28.

Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming Yunnan 650500, China.

Early brain development after birth is extremely dynamic, suggesting that potential functional changes occur during this period. In this study, the maximal electroshock seizure threshold (MEST) was used to explore the electrophysiological variation among three developmental stages in young mice (no more than 5 weeks old). The induced electroshock seizure (ES) behavior of early postnatal mice (1-2-weeks old) differed from that during weaning (3 weeks old) and early puberty (4-5-weeks old). Read More

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http://dx.doi.org/10.24272/j.issn.2095-8137.2019.038DOI Listing

Epilepsy surgery in children: no further threat to theory of mind.

Epileptic Disord 2019 Apr;21(2):166-176

Brain Center Rudolf Magnus, Departments of Child Neurology and Neurosurgery, University Medical Center Utrecht.

To investigate whether theory of mind (ToM), an important requirement for adaptive social functioning, is different between children with pharmacologically refractory epilepsy who undergo epilepsy surgery and healthy control children, whether ToM is affected by epilepsy surgery in these children, and whether ToM is associated with demographic or epilepsy variables. The "ToM storybooks", a psychometrically sound ToM instrument designed for children, was administered shortly before and 0.5, one and two years after surgery as part of a neuropsychological assessment. Read More

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http://dx.doi.org/10.1684/epd.2019.1053DOI Listing
April 2019
1 Read

Multinodular and vacuolating neuronal tumour of the cerebrum: a rare neuroimaging incidentaloma or a potentially treatable cause of focal epilepsy?

Epileptic Disord 2019 Apr;21(2):209-214

Clinic of Neurology.

Multinodular and vacuolating neuronal tumour (MVNT) of the cerebrum is a relatively new, well defined histopathological and neuroradiological entity, in many cases associated with an early adult-onset epilepsy. These lesions have an indolent course and resemble both malformative and neoplastic processes, combining a focal developmental anomaly and a low-grade tumour. Herein, we report a case of a 48-year-old female patient with left temporal lobe epilepsy associated with MVNT. Read More

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http://dx.doi.org/10.1684/epd.2019.1045DOI Listing

Epilepsy: a cross-sectional study of paediatricians and general practitioners on their experiences, knowledge and handling of the disease.

Epileptic Disord 2019 Apr;21(2):197-205

University Hospital for Children and Adolescents, Centre for Paediatric Research, Leipzig, University Hospital for Children and Adolescents, Neuropaediatrics, Rostock, Germany.

Epilepsy is a life-changing disease, and patients with epilepsy may face a number of issues. Paediatricians and general practitioners are often the first to be asked for advice. This cross-sectional study was performed to gain information on the knowledge and experiences of paediatricians and general practitioners on epilepsy. Read More

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http://dx.doi.org/10.1684/epd.2019.1048DOI Listing

Semiology of hyperkinetic seizures of frontal versus temporal lobe origin.

Epileptic Disord 2019 Apr;21(2):154-165

National Epilepsy Center, NHO Shizuoka Institute of Epilepsy and Neurological Disorders, Urushiyama, Aoi-ku, Shizuoka.

Hyperkinetic seizures are usually associated with frontal lobe epilepsy. However, some patients have hyperkinetic seizures of temporal lobe origin. The semiological differences in hyperkinetic seizures between frontal and temporal lobe epilepsy have not been well studied. Read More

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http://dx.doi.org/10.1684/epd.2019.1047DOI Listing

Frequency of post-stroke electroencephalographic epileptiform activity - a systematic review and meta-analysis of observational studies.

Eur Stroke J 2017 Dec 13;2(4):361-368. Epub 2017 Sep 13.

Faculty of Medicine, University of Lisbon, Lisboa, Portugal.

Introduction: Cerebrovascular diseases are the most frequent risk factor for epilepsy in the elderly, and epileptic phenomenon following stroke is known to worsen the prognosis. Although electroencephalography is the gold standard epilepsy biomarker, it is rarely used in post-stroke studies, and the frequency of post-stroke epileptiform activity is still uncertain.

Patients And Methods: We analysed studies indexed to MEDLINE, Embase, Web of Science, PsycINFO and OpenGrey (up to March 2015), reporting post-stroke electroencephalographic epileptiform activity frequency in adults. Read More

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http://dx.doi.org/10.1177/2396987317731004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453191PMC
December 2017

European Stroke Organisation guidelines for the management of post-stroke seizures and epilepsy.

Eur Stroke J 2017 Jun 19;2(2):103-115. Epub 2017 Apr 19.

Department of Neurology, Bispebjerg Hospital and University of Copenhagen, Copenhagen, Denmark.

Background: Following stroke, acute symptomatic seizures (manifestation within seven days) and epilepsy, i.e. occurrence of at least one unprovoked seizure (manifestation after more than seven days), are reported in 3-6% and up to 12% of patients, respectively. Read More

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http://dx.doi.org/10.1177/2396987317705536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453212PMC

Association between poststroke epilepsy and death: A nationwide cohort study.

Eur Stroke J 2016 Dec 8;1(4):272-278. Epub 2016 Sep 8.

Department of Neuroscience, Uppsala University, Sweden.

Introduction: Poststroke epilepsy (PSE) is the most common form of acquired epilepsy after middle age. The primary aim of this study was to study the impact of PSE on prognosis. A secondary aim was to validate recent findings from smaller studies on the risk of developing PSE on a nationwide scale. Read More

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http://dx.doi.org/10.1177/2396987316669000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301246PMC
December 2016

Intelligence and memory outcomes within 10 years of childhood convulsive status epilepticus.

Epilepsy Behav 2019 Apr 18;95:18-25. Epub 2019 Apr 18.

Muir Maxwell Epilepsy Centre, University of Edinburgh, Edinburgh, UK.

Long-term intelligence and memory outcomes of children post convulsive status epilepticus (CSE) have not been systematically investigated despite evidence of short-term impairments in CSE. The present study aimed to describe intelligence and memory outcomes in children within 10 years of CSE and identify potential risk factors for adverse outcomes. In this cohort study, children originally identified by the population-based North London Convulsive Status Epilepticus in Childhood Surveillance Study (NLSTEPSS) were prospectively recruited between July 2009 and February 2013 and invited for neuropsychological assessments and magnetic resonance imaging (MRI) scans. Read More

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http://dx.doi.org/10.1016/j.yebeh.2019.03.039DOI Listing

Lower hemoglobin levels are associated with acute seizures in patients with ruptured cerebral aneurysms.

World Neurosurg 2019 Apr 19. Epub 2019 Apr 19.

Department of Neurosurgery, the First Affiliated Hospital of Fujian Medical University, Fuzhou, China. Electronic address:

Objective: We test the hypothesis that low hemoglobin levels are associated with acute seizures following aneurysmal subarachnoid hemorrhage (aSAH).

Methods: Patients with ruptured intracranial aneurysms were enrolled in the observational cohort study that prospectively collected age, sex, symptom onset, history of diabetes and hypertension, history of coronary artery disease, temperature, Hunt-Hess grade, Fisher grade, aneurysm location, hemoglobin, hematocrit, serum potassium, sodium, calcium, phosphorus, iron, and modified Rankin Scale (mRS). Acute seizures were determined as seizures within one week following aSAH. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.115DOI Listing

A novel variant m.641A>T in the mitochondrial MT-TF gene is associated with epileptic encephalopathy in adolescent.

Mitochondrion 2019 Apr 19. Epub 2019 Apr 19.

Department of Inborn Errors of Metabolism, FSBI 'Research Centre for Medical Genetics', Moscow, Russia.

We present a 14-year-old girl with loss of motor functions, tetraplegia, epilepsy and nystagmus, caused by a novel heteroplasmic m.641A>T transition in an evolutionary conserved region of mitochondrial genome, affecting the aminoacyl stem of mitochondrial tRNA-Phe. In silico prediction, respirometry, Western blot and enzymatic analyses in skin fibroblasts support the pathogenicity of the m. Read More

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http://dx.doi.org/10.1016/j.mito.2019.04.004DOI Listing

Genetic and phenotypic characteristics of SCN1A-related epilepsy in Chinese children.

Neuroreport 2019 Apr 19. Epub 2019 Apr 19.

Department of Neurology, Children's Hospital of Chongqing Medical University.

SCN1A gene mutations are associated with epilepsy and neurodevelopmental disorders. This study aimed to explore the genotype and phenotype spectrum of SCN1A gene related epilepsy. Epileptic patients who were treated in the Children's Hospital of Chongqing Medical University from January 2015 to July 2018 and identified as having SCN1A mutations by targeted next-generation sequencing were included. Read More

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http://Insights.ovid.com/crossref?an=00001756-900000000-9814
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http://dx.doi.org/10.1097/WNR.0000000000001259DOI Listing
April 2019
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Dexmedetomidine for Electrocorticography in Patients With Lennox-Gastaut Syndrome Presenting for Epilepsy Surgery: A Case Report.

A A Pract 2019 Apr 17. Epub 2019 Apr 17.

From the Division of Neuroanesthesia, Department of Anaesthesiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India.

We report the anesthetic management of 2 patients with Lennox-Gastaut syndrome presenting for respective epilepsy surgery with intraoperative electrocorticography. Electrocorticography is a useful tool to guide the localization of the epileptogenic focus for surgical resection in epilepsy surgery. Drug interactions, proconvulsant or anticonvulsant activity of the anesthetics, and anesthetic influence on intraoperative electrocorticography are the primary concerns to be addressed in these patients. Read More

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http://dx.doi.org/10.1213/XAA.0000000000001020DOI Listing
April 2019
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The Role of FDG-PET in Patients with Epilepsy Related to Periventricular Nodular Heterotopias: Diagnostic Features and Long-Term Outcome.

J Neuroimaging 2019 Apr 22. Epub 2019 Apr 22.

Clinic of Radiology & Nuclear Medicine, University Hospital Basel, University of Basel, Basel, Switzerland.

Background And Purpose: Periventricular nodular heterotopias (PNHs) are frequently associated with drug-resistant epilepsy (DRE). Although magnetic resonance imaging (MRI) can define the morphological features of PNHs, still there is a need to assess their metabolic activity in order to provide useful information on epileptogenicity and long-term outcome. To that end, we investigated the ability of F-FDG PET to identify seizure onset zone in order to assess the metabolic activity of the ectopic neurons and to provide prognostic information on the postsurgical outcome. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jon.12620
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http://dx.doi.org/10.1111/jon.12620DOI Listing
April 2019
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Reproducibility of interictal spike propagation in children with refractory epilepsy.

Epilepsia 2019 Apr 21. Epub 2019 Apr 21.

School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, New York.

Objective: Interictal spikes are a characteristic feature of invasive electroencephalography (EEG) recordings in children with refractory epilepsy. Spikes frequently co-occur across multiple brain regions with discernable latencies, suggesting that spikes can propagate through distributed neural networks. The purpose of this study was to examine the long-term reproducibility of spike propagation patterns over hours to days of interictal recording. Read More

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http://dx.doi.org/10.1111/epi.14720DOI Listing

Age-Dependency of Levetiracetam Effects on Exocytotic GABA Release from Nerve Terminals in the Hippocampus and Cortex in Norm and After Perinatal Hypoxia.

Cell Mol Neurobiol 2019 Apr 20. Epub 2019 Apr 20.

The Department of Neurochemistry, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, 9 Leontovicha Str, Kiev, 01030, Ukraine.

Perinatal hypoxia can lead to multiple chronic neurological deficits, e.g., mental retardation, behavioral abnormalities, and epilepsy. Read More

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http://dx.doi.org/10.1007/s10571-019-00676-6DOI Listing
April 2019
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Children Born to Mothers with Rash During Zika Virus Epidemic in Brazil: First 18 Months of Life.

J Trop Pediatr 2019 Apr 21. Epub 2019 Apr 21.

Faculdade de Medicina, Universidade Federal Fluminense, RJ 24.033-900, Brazil.

Objective: To better understand the clinical spectrum and course of congenital Zika syndrome (CZS) during the first 18 months of life of children whose mothers had rash during pregnancy.

Methods: This longitudinal observational study evaluated the clinical progress from birth until 18 months of life of children of mothers who developed rash during or up to 3 months before gestation. Maternal rash occurred from November 2015 to May 2017. Read More

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https://academic.oup.com/tropej/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/tropej/fmz019DOI Listing
April 2019
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National registry for sudden unexpected deaths of infants and children in England: why do we need one and do families want one?

Arch Dis Child 2019 Apr 20. Epub 2019 Apr 20.

Child and Adolescent Health, University of Bristol, Bristol, UK.

The sudden and unexpected death of an infant or child is devastating. An inability to explain why an infant or child died is difficult to accept for both families and professionals. No reliable national dataset exists to estimate precisely how many infants and children die unexpectedly each year in England. Read More

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http://dx.doi.org/10.1136/archdischild-2018-316542DOI Listing
April 2019
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Reversible uraemic encephalopathy.

BMJ Case Rep 2019 Apr 20;12(4). Epub 2019 Apr 20.

Neurology, All India Institute of Medical Sciences, New Delhi, India.

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http://dx.doi.org/10.1136/bcr-2018-228261DOI Listing

Teratogenic potential of third-generation antiepileptic drugs: Current status and research needs.

Pharmacol Rep 2019 Jan 31;71(3):491-502. Epub 2019 Jan 31.

Neurobiology Lab, Department of Zoology, University of Allahabad, Allahabad, India. Electronic address:

The aim of this review was to scrutinize the current literature available on teratogenic safety of third-generation antiepileptic drugs (TGAEDs) considering their clinical implications and to highlight for further research need in the interest of the diseased population in general and women with epilepsy in particular. For evaluation of the teratogenic potential of TGAEDs, this review summarized the existing information on controlled clinical trials conducted by the pharmaceutical companies, case reports, scholarly articles (prospective and retrospective studies), and experimental tests carried out so far. Firstly, clinical reports have reviewed on each drug followed by non-clinical studies reported hitherto. Read More

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http://dx.doi.org/10.1016/j.pharep.2019.01.011DOI Listing
January 2019