11,160 results match your criteria Epilepsia[Journal]


Cannabis-based products for pediatric epilepsy: A systematic review.

Epilepsia 2018 Dec 4. Epub 2018 Dec 4.

School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada.

Objective: To assess the benefits and harms of cannabis-based products for pediatric epilepsy.

Methods: We identified in this living systematic review randomized controlled trials (RCTs) and nonrandomized studies (NRSs) involving children with epilepsy treated with cannabis-based products. We searched MEDLINE, Embase, PsycINFO, Cochrane Library, and gray literature (April 25, 2018). Read More

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December 2018
1 Read

Diagnostic and prognostic value of noninvasive long-term video-electroencephalographic monitoring in epilepsy surgery: A systematic review and meta-analysis from the E-PILEPSY consortium.

Epilepsia 2018 Dec 22;59(12):2272-2283. Epub 2018 Nov 22.

Department of Neurology, Christian-Doppler-Klinik, Paracelsus Medical University, Salzburg, Austria.

Objective: The European Union-funded E-PILEPSY network (now continuing within the European Reference Network for rare and complex epilepsies [EpiCARE]) aims to harmonize and optimize presurgical diagnostic procedures by creating and implementing evidence-based guidelines across Europe. The present study evaluates the current evidence on the diagnostic accuracy of long-term video-electroencephalographic monitoring (LTM) in identifying the epileptogenic zone in epilepsy surgery candidates.

Methods: MEDLINE, Embase, CENTRAL, and ClinicalTrials. Read More

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December 2018
1 Read

Erratum.

Authors:

Epilepsia 2018 Dec 19;59(12):2344. Epub 2018 Nov 19.

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December 2018

Temporal trends and patterns in carbamazepine use, related severe cutaneous adverse reactions, and HLA-B*15:02 screening: A nationwide study.

Epilepsia 2018 Dec 26;59(12):2325-2339. Epub 2018 Nov 26.

Graduate Institute of Clinical Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan.

Objective: After discovering the association between the HLA-B*15:02 allele and carbamazepine-related severe cutaneous adverse reactions (SCARs), particularly in Southeastern Asian populations, clinical strategies to prevent carbamazepine-related SCARs have changed. We aimed to investigate 10-year trends in carbamazepine use and carbamazepine-related SCARs and to examine the patterns and determinants of HLA-B*15:02 screening in Taiwan.

Methods: A nationwide study was performed using Taiwan's National Health Insurance Research Database. Read More

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December 2018
1 Read

Alterations in the hippocampal-thalamic pathway underlying secondarily generalized tonic-clonic seizures in mesial temporal lobe epilepsy: A diffusion tensor imaging study.

Epilepsia 2018 Nov 26. Epub 2018 Nov 26.

Department of Neurology, Epilepsy Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Objective: The epileptogenic network underlying secondarily generalized tonic-clonic seizures (sGTCS) in mesial temporal lobe epilepsy (mTLE) is not well understood. Here, we investigated alterations in the probabilistic hippocampal-thalamic pathway (pHTP) underlying sGTCS using diffusion tensor imaging and resting-state functional magnetic resonance imaging in a cohort of TLE patients with hippocampal sclerosis (HS).

Methods: We consecutively recruited 51 unilateral TLE-HS patients (26 with and 25 without sGTCS) and 22 healthy controls. Read More

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November 2018
10 Reads

Homomeric Kv7.2 current suppression is a common feature in KCNQ2 epileptic encephalopathy.

Epilepsia 2018 Nov 26. Epub 2018 Nov 26.

Biofisika Institute, The Spanish National Research Council/University of the Basque Country, Leioa, Spain.

Objective: To gain insight into the mechanisms underlying KCNQ2 encephalopathy by examining the electrophysiologic properties of mutant Kv7.2 channels in different multimeric configurations.

Methods: We analyzed the genotype-phenotype relationship in 4 patients with KCNQ2 encephalopathy and performed electrophysiologic analysis of M-currents mediated by homomeric Kv7. Read More

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November 2018
3 Reads

Epidemiology of status epilepticus in adults: A population-based study on incidence, causes, and outcomes.

Epilepsia 2018 Nov 26. Epub 2018 Nov 26.

Department of Public Health, Health Services Research and Health Technology Assessment, UMIT - University for Health Sciences, Medical Informatics and Technology, Hall in Tirol, Austria.

Objective: In 2015, the International League Against Epilepsy (ILAE) proposed a new definition of status epilepticus (SE): 5 minutes of ongoing seizure activity to diagnose convulsive SE (CSE, ie, bilateral tonic-clonic SE) and 10 minutes for focal SE and absence SE, rather than the earlier criterion of 30 minutes. Based on semiology, several types of SE with prominent motor phenomena at any time (including CSE) were distinguished from those without (ie, nonconvulsive SE, NCSE). We present the first population-based incidence study applying the new 2015 ILAE definition and classification of SE and report the impact of the evolution of semiology and level of consciousness (LOC) on outcome. Read More

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November 2018

Commentary on Nóbrega-Jr et al. "Mesial temporal lobe epilepsy with hippocampal sclerosis is infrequently associated with neuronal antibodies".

Authors:
Niels Hansen

Epilepsia 2018 Dec 19;59(12):2340-2341. Epub 2018 Nov 19.

Department of Epileptology, University of Bonn, Bonn, Germany.

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December 2018
1 Read

Defining the electroclinical phenotype and outcome of PCDH19-related epilepsy: A multicenter study.

Epilepsia 2018 Dec 19;59(12):2260-2271. Epub 2018 Nov 19.

Neurology Unit, Department of Neuroscience, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Objective: PCDH19-related epilepsy is an epileptic syndrome with infantile onset, characterized by clustered and fever-induced seizures, often associated with intellectual disability (ID) and autistic features. The aim of this study was to analyze a large cohort of patients with PCDH19-related epilepsy and better define the epileptic phenotype, genotype-phenotype correlations, and related outcome-predicting factors.

Methods: We retrospectively collected genetic, clinical, and electroencephalogram (EEG) data of 61 patients with PCDH19-related epilepsy followed at 15 epilepsy centers. Read More

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December 2018
9 Reads

High long-term mortality after incident status epilepticus in adults: Results from a population-based study.

Epilepsia 2018 Nov 13. Epub 2018 Nov 13.

Department of Neurology, Odense University Hospital, Odense, Denmark.

Objective: To determine annual incidence, etiology, severity, and short- and long-term mortality of first-time, nonanoxic status epilepticus (SE) in adults in a population-based retrospective cohort study.

Methods: We systematically identified all episodes of SE in the year 2014 on the island of Funen. Patients with SE due to anoxia, patients with recurrent SE, and patients <18 years old were excluded. Read More

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November 2018
1 Read

The epidemiology of drug-resistant epilepsy: A systematic review and meta-analysis.

Epilepsia 2018 Dec 13;59(12):2179-2193. Epub 2018 Nov 13.

Refractory Epilepsy Unit, Neurology Service, Hospital Universitario y Politécnico La Fe, Valencia, Spain.

Objective: The definition of drug-resistant epilepsy (DRE) affects case identification and treatment, and impacts prevalence or incidence estimates and health burden estimation in epidemiology. The objective of this systematic review is to evaluate the consistency between definitions of DRE in the literature and the official definition in the International League Against Epilepsy (ILAE) guidelines, and to estimate the incidence, prevalence, and risk factors for DRE.

Methods: MEDLINE and EMBASE were searched for observational studies of DRE published between January 1980 and July 2015. Read More

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December 2018
3 Reads

The repertoire of seizure onset patterns in human focal epilepsies: Determinants and prognostic values.

Epilepsia 2018 Nov 13. Epub 2018 Nov 13.

Epileptology Department, National Institute of Health and Medical Research, Institute of System Neuroscience, Timone Hospital, Public Assistance Hospitals of Marseille, Aix-Marseille University, Marseille, France.

Objective: In this study, we seek to analyze the determinants of the intracranial electroencephalography seizure onset pattern (SOP) and the impact of the SOP in predicting postsurgical seizure outcome.

Methods: To this end, we analyzed 820 seizures from 252 consecutive patients explored by stereo-electroencephalography (total of 2148 electrodes), including various forms of focal refractory epilepsies. We used a reproducible method combining visual and time-frequency analyses. Read More

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November 2018

Corpus callosum low-frequency stimulation suppresses seizures in an acute rat model of focal cortical seizures.

Epilepsia 2018 Dec 13;59(12):2219-2230. Epub 2018 Nov 13.

Department of Biomedical Engineering, Neural Engineering Center, Case Western Reserve University, Cleveland, Ohio.

Objective: Low-frequency fiber-tract stimulation has been shown to be effective in treating mesial temporal lobe epilepsies through activation of the hippocampal commissure in rodents and human patients. The corpus callosum is a major pathway connecting the two hemispheres of the brain; however, few experiments have documented corpus callosum stimulation. The objective is to determine the efficacy of corpus callosum stimulation at low frequencies to suppress cortical seizures. Read More

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December 2018
1 Read

Cognitive outcomes following epilepsy in infancy: A longitudinal community-based study.

Epilepsia 2018 Dec 5;59(12):2240-2248. Epub 2018 Nov 5.

University College London Great Ormond Street Institute of Child Health, London, UK.

Objective: Onset of epilepsy before 2 years of age is associated with poor cognitive outcome; however, the natural course of the range of epilepsies that occur at this age is unknown. The aim of this prospective community-based study was to investigate the neuropsychological development of infants with newly diagnosed epilepsy longitudinally and to identify the clinical factors that predict long-term impairment.

Methods: Sixty-six infants <24 months of age were enrolled in the baseline phase of this study; 40 were seen again at 1-year follow-up and 40 at 3-year follow-up. Read More

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December 2018
5 Reads

Surgical and developmental outcomes of corpus callosotomy for West syndrome in patients without MRI lesions.

Epilepsia 2018 Dec 5;59(12):2231-2239. Epub 2018 Nov 5.

Department of Neurosurgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

Objective: This retrospective study was designed to assess the impact of corpus callosotomy (CC) in patients with intractable West syndrome (WS) without lesions on magnetic resonance imaging (MRI).

Methods: This study involved 56 patients with WS who underwent CC between January 2000 and December 2014. Seizure outcomes and changes in psychomotor development were analyzed. Read More

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December 2018
2 Reads

Stevens-Johnson syndrome and toxic epidermal necrolysis with antiepileptic drugs: An analysis of the US Food and Drug Administration Adverse Event Reporting System.

Epilepsia 2018 Dec 5;59(12):2318-2324. Epub 2018 Nov 5.

University of Rhode Island College of Pharmacy, Kingston, Rhode Island.

Objective: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare and potentially fatal adverse skin reactions that are most commonly triggered by certain medications. One class of medications that has been highly associated with SJS/TEN reactions is antiepileptic drugs (AEDs). We sought to quantify the risk of SJS/TEN associated with AEDs as a class, as well as individual AEDs, in the United States. Read More

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December 2018
2 Reads

Hot water epilepsy and SYN1 variants.

Epilepsia 2018 Nov;59(11):2162-2163

Child Neuropsychiatric Unit, Epilepsy Center, San Paolo Hospital, Department of Health Sciences, University of Milan, Milan, Italy.

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November 2018
4.570 Impact Factor

Corrigendum.

Authors:

Epilepsia 2018 Nov;59(11):2166

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November 2018

Corrigendum.

Authors:

Epilepsia 2018 Nov;59(11):2167

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November 2018

Diagnostic accuracy of functional magnetic resonance imaging, Wada test, magnetoencephalography, and functional transcranial Doppler sonography for memory and language outcome after epilepsy surgery: A systematic review.

Epilepsia 2018 Dec 30;59(12):2305-2317. Epub 2018 Oct 30.

Department of Neurology, Christian Doppler Medical Center, Paracelsus Medical University, Salzburg, Austria.

Objective: The European Union-funded E-PILEPSY project was launched to develop guidelines and recommendations for epilepsy surgery. In this systematic review, we aimed to assess the diagnostic accuracy of functional magnetic resonance imaging (fMRI), Wada test, magnetoencephalography (MEG), and functional transcranial Doppler sonography (fTCD) for memory and language decline after surgery.

Methods: The literature search was conducted using PubMed, Embase, and CENTRAL. Read More

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December 2018
2 Reads

Subcentimeter epilepsy surgery targets by resting state functional magnetic resonance imaging can improve outcomes in hypothalamic hamartoma.

Epilepsia 2018 Dec 30;59(12):2284-2295. Epub 2018 Oct 30.

Department of Pediatric Neurosurgery, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas.

Objective: The purpose of this study is to investigate the outcomes of epilepsy surgery targeting the subcentimeter-sized resting state functional magnetic resonance imaging (rs-fMRI) epileptogenic onset zone (EZ) in hypothalamic hamartoma (HH).

Methods: Fifty-one children with HH-related intractable epilepsy received anatomical MRI-guided stereotactic laser ablation (SLA) procedures. Fifteen of these children were control subjects (CS) not guided by rs-fMRI. Read More

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December 2018
10 Reads

Interregional metabolic connectivity of 2-deoxy-2[ F]fluoro-D-glucose positron emission tomography in vagus nerve stimulation for pediatric patients with epilepsy: A retrospective cross-sectional study.

Epilepsia 2018 Dec 28;59(12):2249-2259. Epub 2018 Oct 28.

Division of Pediatric Neurology, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, Korea.

Objective: With the recognition of epilepsy as a network disease that disrupts the organizing ability of resting-state brain networks, vagus nerve stimulation (VNS) may control epileptic seizures through modulation of functional connectivity. We evaluated preoperative 2-deoxy-2[ F]fluoro-D-glucose (FDG) positron emission tomography (PET) in VNS-implanted pediatric patients with refractory epilepsy to analyze the metabolic connectivity of patients and its prognostic role in seizure control.

Methods: Preoperative PET data of 66 VNS pediatric patients who were followed up for a minimum of 1 year after the procedure were collected for the study. Read More

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December 2018
8 Reads

Imaging biomarkers of behavioral impairments: A pilot micro-positron emission tomographic study in a rat electrical post-status epilepticus model.

Epilepsia 2018 Dec 28;59(12):2194-2205. Epub 2018 Oct 28.

Institute of Pharmacology, Toxicology, and Pharmacy, Ludwig Maximilian University of Munich, Munich, Germany.

Objective: In patients with epilepsy, psychiatric comorbidities can significantly affect the disease course and quality of life. Detecting and recognizing these comorbidities is central in determining an optimal treatment plan. One promising tool in detecting biomarkers for psychiatric comorbidities in epilepsy is positron emission tomography (PET). Read More

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December 2018
5 Reads

Soman-induced status epilepticus, epileptogenesis, and neuropathology in carboxylesterase knockout mice treated with midazolam.

Epilepsia 2018 Dec 25;59(12):2206-2218. Epub 2018 Oct 25.

US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland.

Objective: Exposure to chemical warfare nerve agents (CWNAs), such as soman (GD), can induce status epilepticus (SE) that becomes refractory to benzodiazepines when treatment is delayed, leading to increased risk of epileptogenesis, severe neuropathology, and long-term behavioral and cognitive deficits. Rodent models, widely used to evaluate novel medical countermeasures (MCMs) against CWNA exposure, normally express plasma carboxylesterase, an enzyme involved in the metabolism of certain organophosphorus compounds. To better predict the efficacy of novel MCMs against CWNA exposure in human casualties, it is crucial to use appropriate animal models that mirror the human condition. Read More

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December 2018
3 Reads

Progress report on new antiepileptic drugs: A summary of the Fourteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIV). I. Drugs in preclinical and early clinical development.

Epilepsia 2018 Oct;59(10):1811-1841

Department of Pharmacy, School of Pharmacy, University of Washington, Seattle, Washington.

The Fourteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIV) took place in Madrid, Spain, on May 13-16, 2018 and was attended by 168 delegates from 28 countries. The conference provided a forum for professionals involved in basic science, clinical research, regulatory affairs, and clinical care to meet and discuss the latest advances related to discovery and development of drugs and devices aimed at improving the management of people with epilepsy. This progress report provides a summary of findings on investigational compounds for which data from preclinical or early (phase I) clinical studies were presented. Read More

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October 2018
8 Reads

Erratum.

Authors:

Epilepsia 2018 Oct;59(10):2004

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October 2018

Response to "Screening for depression in youth with epilepsy: The NDDI-E-Y".

Epilepsia 2018 Oct;59(10):2000-2001

College of Nursing, Medical University of South Carolina, Charleston, South Carolina.

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October 2018
3 Reads

Progress report on new antiepileptic drugs: A summary of the Fourteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIV). II. Drugs in more advanced clinical development.

Epilepsia 2018 Oct;59(10):1842-1866

Department of Pharmacy, School of Pharmacy, University of Washington, Seattle, Washington.

The Fourteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIV) took place in Madrid, Spain, on May 13-16, 2018 and was attended by 168 delegates from 28 countries. The conference provided a forum for professionals involved in basic science, clinical research, regulatory affairs, and clinical care to meet and discuss the latest advances related to discovery and development of drugs and devices aimed at improving the management of people with epilepsy. This progress report provides a summary of findings on investigational compounds for which data from both preclinical studies and studies in patients were presented. Read More

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October 2018
7 Reads

Screening for depression in youth with epilepsy: The NDDI-E-Y.

Epilepsia 2018 Oct;59(10):1999-2000

Aix-Marseille University, INSERM, INS, Inst Neurosci Syst, Marseille, France.

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October 2018
5 Reads

Pharmacokinetics of clobazam oral soluble film.

Epilepsia 2018 Nov 24;59(11):2153-2161. Epub 2018 Oct 24.

Aquestive Therapeutics, Inc, Warren, New Jersey.

Objective: Clobazam oral soluble film (COSF) is a novel dosage form under development for the adjunctive treatment of seizures associated with Lennox-Gastaut syndrome. The present study was undertaken to assess the pharmacokinetics of clobazam administered as single doses of COSF 20 and 10 mg compared with clobazam tablets (CTAB) 20 and 10 mg in healthy adults. A secondary objective was to assess the safety and tolerability of single doses of COSF 20 and 10 mg. Read More

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November 2018
4 Reads

Stereo-electroencephalography-guided radiofrequency thermocoagulation in patients with focal epilepsy: A systematic review and meta-analysis.

Epilepsia 2018 Dec 21;59(12):2296-2304. Epub 2018 Oct 21.

Faculty of Medicine Claude Bernard, University of Lyon, Lyon, France.

Objective: Despite the increasing number of studies reporting results of stereo-electroencephalography (SEEG)-guided radiofrequency-thermocoagulation (SEEG-guided RF-TC) in the treatment of patients with drug-resistant focal epilepsy, the exact efficacy of this approach remains unclear. The seizure-freedom rate varies greatly across studies and the factors associated with efficacy have not been formally investigated.

Methods: All prospective or retrospective studies reporting efficacy and/or safety of SEEG-guided RF-TC in patients with drug-resistant focal epilepsy were included. Read More

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December 2018
3 Reads

Heart rate variability measurement in epilepsy: How can we move from research to clinical practice?

Epilepsia 2018 Dec 21;59(12):2169-2178. Epub 2018 Oct 21.

Department of Medicine, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia.

Our objective was to critically evaluate the literature surrounding heart rate variability (HRV) in people with epilepsy and to make recommendations as to how future research could be directed to facilitate and accelerate integration into clinical practice. We reviewed relevant HRV publications including those involving human subjects with seizures. HRV has been studied in patients with epilepsy for more than 30 years and, overall, patients with epilepsy display altered interictal HRV, suggesting a shift in autonomic balance toward sympathetic dominance. Read More

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December 2018

Guideline-based and bioinformatic reassessment of lesion-associated gene and variant pathogenicity in focal human epilepsies.

Epilepsia 2018 Nov 20;59(11):2145-2152. Epub 2018 Oct 20.

Cologne Center for Genomics, University of Cologne, Cologne, Germany.

Objective: Increasing availability of surgically resected brain tissue from patients with focal epilepsy and focal cortical dysplasia or low-grade glioneuronal tumors has fostered large-scale genetic examination. However, assessment of pathogenicity of germ line and somatic variants remains difficult. Here, we present a state-of-the-art evaluation of reported genes and variants associated with epileptic brain lesions. Read More

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November 2018
1 Read

No latency to dentate granule cell epileptogenesis in experimental temporal lobe epilepsy with hippocampal sclerosis.

Epilepsia 2018 Nov 19;59(11):2019-2034. Epub 2018 Oct 19.

Neuroscience Institute, Morehouse School of Medicine, Atlanta, Georgia.

Objective: To determine when spontaneous granule cell epileptiform discharges first occur after hippocampal injury, and to identify the postinjury "latent" period as either a "silent" gestational state of epileptogenesis or a subtle epileptic state in gradual transition to a more obvious epileptic state.

Methods: Nonconvulsive status epilepticus evoked by perforant path stimulation in urethane-sedated rats produced selective and extensive hippocampal injury and a "latent" period that preceded the onset of the first clinically obvious epileptic seizures. Continuous granule cell layer depth recording and video monitoring assessed the time course of granule cell hyperexcitability and the onset/offset times of spontaneous epileptiform discharges and behavioral seizures. Read More

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November 2018
3 Reads

Epilepsy surgery in Panama: Establishment of a successful hybrid program as a model for small middle-income countries.

Epilepsia 2018 Nov 19;59(11):2137-2144. Epub 2018 Oct 19.

Division of Pediatric Neurosurgery, Department of Surgery, Texas Children's Hospital and Department of Neurosurgery, Baylor College of Medicine, Houston, Texas.

Objective: The majority of the 65 million people worldwide with epilepsy live in low- and middle-income countries. Many of these countries have inadequate resources to serve the large patient population affected by epilepsy. Panama is a middle-income country that currently has only 2 facilities that can provide basic epilepsy services and no epilepsy surgery services. Read More

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November 2018
2 Reads

Recurrent epileptiform discharges in the medial entorhinal cortex of kainate-treated rats are differentially sensitive to antiseizure drugs.

Epilepsia 2018 Nov 17;59(11):2035-2048. Epub 2018 Oct 17.

Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah.

Objective: Approximately 30% of patients with epilepsy are refractory to existing antiseizure drugs (ASDs). Given that the properties of the central nervous systems of these patients are likely to be altered due to their epilepsy, tissues from rodents that have undergone epileptogenesis might provide a therapeutically relevant disease substrate for identifying compounds capable of attenuating pharmacoresistant seizures. To facilitate the development of such a model, this study describes the effects of classical glutamate receptor antagonists and 20 ASDs on recurrent epileptiform discharges (REDs) in brain slices derived from the kainate-induced status epilepticus model of temporal lobe epilepsy (KA-rats). Read More

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November 2018
1 Read

Abnormal temporal lobe morphology in asymptomatic relatives of patients with hippocampal sclerosis: A replication study.

Epilepsia 2018 Oct 15. Epub 2018 Oct 15.

Department of Basic & Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

We investigated gray and white matter morphology in patients with mesial temporal lobe epilepsy with hippocampal sclerosis (mTLE+HS) and first-degree asymptomatic relatives of patients with mTLE+HS. Using T1-weighted magnetic resonance imaging (MRI), we sought to replicate previously reported findings of structural surface abnormalities of the anterior temporal lobe in asymptomatic relatives of patients with mTLE+HS in an independent cohort. We performed whole-brain MRI in 19 patients with mTLE+HS, 14 first-degree asymptomatic relatives of mTLE+HS patients, and 32 healthy control participants. Read More

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October 2018
1 Read
4.570 Impact Factor

γ-Aminobutyric acid receptor alpha 1 subunit loss of function causes genetic generalized epilepsy by impairing inhibitory network neurodevelopment.

Epilepsia 2018 Nov 15;59(11):2061-2074. Epub 2018 Oct 15.

Department of Neurosciences, Research Center of the University of Montreal Hospital Center, University of Montreal, Montreal, Quebec, Canada.

Objective: In humans, mutations of the γ-aminobutyric acid receptor subunit 1 (GABRA1) cause either mild or severe generalized epilepsy. Although these epilepsy-causing mutations have been shown to disrupt the receptor activity in vitro, their in vivo consequences on brain development and activity are not known. Here, we aim at unraveling the epileptogenesis mechanisms of GABRA1 loss of function. Read More

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November 2018

Perampanel and decanoic acid show synergistic action against AMPA receptors and seizures.

Epilepsia 2018 Nov 15;59(11):e172-e178. Epub 2018 Oct 15.

Centre for Biomedical Sciences, School of Biological Sciences, Royal Holloway University of London, Egham, UK.

Perampanel is an adjunctive treatment for epilepsy that works through the direct inhibition of AMPA receptors. The same molecular mechanism has recently been shown for a fatty acid, decanoic acid, prescribed in the medium chain triglyceride ketogenic diet for the treatment of patients with drug-resistant epilepsy. Because each compound has been proposed to act through a distinct AMPA receptor binding site, we predicted that perampanel and decanoic acid would act synergistically against AMPA receptors and, consequently, seizures. Read More

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November 2018
2 Reads

A novel GABAergic dysfunction in human Dravet syndrome.

Epilepsia 2018 Nov 11;59(11):2106-2117. Epub 2018 Oct 11.

Department of Physiology and Pharmacology, Pasteur Institute-Cenci Bolognetti Foundation, Sapienza University of Rome, Rome, Italy.

Objective: Dravet syndrome is a rare neurodevelopmental disease, characterized by general cognitive impairment and severe refractory seizures. The majority of patients carry the gene mutation SCN1A, leading to a defective sodium channel that contributes to pathogenic brain excitability. A γ-aminobutyric acid (GABAergic) impairment, as in other neurodevelopmental diseases, has been proposed as an additional mechanism, suggesting that seizures could be alleviated by GABAergic therapies. Read More

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November 2018
1 Read

Effects of galanin receptor 2 and receptor 3 knockout in mouse models of acute seizures.

Epilepsia 2018 Nov 8;59(11):e166-e171. Epub 2018 Oct 8.

Department of Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.

There exists solid evidence that endogenous galanin and galanin agonists exert anticonvulsive actions mediated both by galanin 1 receptor (GAL1-R) and galanin 2 receptor (GAL2-R). We have now investigated whether depletion of the recently identified third galanin receptor, GAL3-R, and that of GAL2-R, alters the threshold to the systemically applied γ-aminobutyric acid (GABA) antagonist pentylenetetrazole (PTZ) or to intrahippocampally administered kainic acid (KA). In neither model, GAL3-KO mice differed in their latency to the first seizure, mean seizure duration, total number of seizures, or time spent in seizures compared to wild-type controls. Read More

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November 2018
1 Read
4.570 Impact Factor

Regulatory aspects of status epilepticus.

Epilepsia 2018 Oct;59 Suppl 2:128-134

Department of Neurology, Paracelsus Medical University, Christian Doppler Medical Center, Salzburg, Austria.

In this article, we consider four aspects of the regulatory standing of status epilepticus and the difficulties these raise in relation to trials and licensing. These formed the basis of a discussion held at the 6th London?Innsbruck Colloquium on Status Epilepticus, held on April 6, 2017. Read More

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October 2018
1 Read

Progressive dissociation of cortical and subcortical network development in children with new-onset juvenile myoclonic epilepsy.

Epilepsia 2018 Nov 3;59(11):2086-2095. Epub 2018 Oct 3.

Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.

Objective: Structural and functional magnetic resonance imaging (MRI) studies have consistently documented cortical and subcortical abnormalities in patients with juvenile myoclonic epilepsy (JME). However, little is known about how these structural abnormalities emerge from the time of epilepsy onset and how network interactions between and within cortical and subcortical regions may diverge in youth with JME compared to typically developing children.

Methods: We examined prospective covariations of volumetric differences derived from high-resolution structural MRI during the first 2 years of epilepsy diagnosis in a group of youth with JME (n = 21) compared to healthy controls (n = 22). Read More

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November 2018
4 Reads
4.570 Impact Factor

Provocative induction of psychogenic nonepileptic seizures: Noninferiority of an induction technique without versus with placebo.

Epilepsia 2018 Nov 1;59(11):e161-e165. Epub 2018 Oct 1.

Neurology Care Line, Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas.

We aim to demonstrate, in a sufficiently powered and standardized study, that the success rate of inducing psychogenic nonepileptic seizures (PNES) without placebo (saline infusion) is noninferior to induction with placebo. The clinical data of 170 consecutive patients with suspected PNES who underwent induction with placebo from January 21, 2009 to March 31, 2013 were pair-matched with 170 consecutive patients with suspected PNES who underwent the same induction technique but without addition of placebo from April 1, 2013 to February 7, 2018 at the same center. The success rates of induction were 79. Read More

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November 2018
4 Reads

Modulation of glucocorticoid receptor in human epileptic endothelial cells impacts drug biotransformation in an in vitro blood-brain barrier model.

Epilepsia 2018 Nov 28;59(11):2049-2060. Epub 2018 Sep 28.

Epilepsy Center, Neurological Institute, Cleveland Clinic, Cleveland, Ohio.

Objective: Nuclear receptors and cytochrome P450 (CYP) regulate hepatic metabolism of several drugs. Nuclear receptors are expressed at the neurovascular unit of patients with drug-resistant epilepsy. We studied whether glucocorticoid receptor (GR) silencing or inhibition in human epileptic brain endothelial cells (EPI-ECs) functionally impacts drug bioavailability across an in vitro model of the blood-brain barrier (BBB) by CYP-multidrug transporter (multidrug resistance protein 1, MDR1) mechanisms. Read More

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November 2018

Epilepsy-predictive magnetic resonance imaging changes following experimental febrile status epilepticus: Are they translatable to the clinic?

Epilepsia 2018 Nov 6;59(11):2005-2018. Epub 2018 Sep 6.

Department of Anatomy/Neurobiology, University of California, Irvine, Irvine, California.

Objective: A subset of children with febrile status epilepticus (FSE) are at risk for development of temporal lobe epilepsy later in life. We sought a noninvasive predictive marker of those at risk that can be identified soon after FSE, within a clinically realistic timeframe.

Methods: Longitudinal T -weighted magnetic resonance imaging (T WI MRI) of rat pups at several time points after experimental FSE (eFSE) was performed on a high-field scanner followed by long-term continuous electroencephalography. Read More

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November 2018
4 Reads

Evolution and course of early life developmental encephalopathic epilepsies: Focus on Lennox-Gastaut syndrome.

Epilepsia 2018 Nov 26;59(11):2096-2105. Epub 2018 Sep 26.

Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut.

Objectives: Developmental encephalopathic epilepsies (DEEs) are characterized by refractory seizures, disability, and early death. Opportunities to improve care and outcomes focus on West syndrome/infantile spasms (WS/IS). Lennox-Gastaut syndrome (LGS) is almost as common but receives little attention. Read More

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November 2018
1 Read