11,212 results match your criteria Epilepsia[Journal]


Indoleamine 2,3-dioxygenase 1 deletion promotes Theiler's virus-induced seizures in C57BL/6J mice.

Epilepsia 2019 Feb 15. Epub 2019 Feb 15.

Department of Animal Sciences, College of Agricultural, Consumer, and Environmental Sciences, Urbana, Illinois.

Objective: Viral encephalitis increases the risk for developing seizures and epilepsy. Indoleamine 2,3-dioxygenase 1 (Ido1) is induced by inflammatory cytokines and functions to metabolize tryptophan to kynurenine. Kynurenine can be further metabolized to produce kynurenic acid and the N-methyl-d-aspartate receptor agonist quinolinic acid (QuinA). Read More

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http://dx.doi.org/10.1111/epi.14675DOI Listing
February 2019

The effect of medial pulvinar stimulation on temporal lobe seizures.

Epilepsia 2019 Feb 14. Epub 2019 Feb 14.

Clinical Neurophysiology and Epileptology Department, Timone Hospital, Assitance Publique Hôpitaux de Marseille, Marseille, France.

We investigated the effect of electrical stimulation of the medial pulvinar (PuM) in terms of its effect on temporal lobe seizures. Eight patients with drug-resistant temporal lobe epilepsy undergoing stereoelectroencephalographic exploration were included. All had at least one electrode exploring the PuM. Read More

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http://dx.doi.org/10.1111/epi.14677DOI Listing
February 2019

Ventilatory response to CO in patients with epilepsy.

Epilepsia 2019 Feb 12. Epub 2019 Feb 12.

Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, Iowa.

Objective: Severe periictal respiratory depression is thought to be linked to risk of sudden unexpected death in epilepsy (SUDEP) but its determinants are largely unknown. Interindividual differences in the interictal ventilatory response to CO (hypercapnic ventilatory response [HCVR] or central respiratory CO chemosensitivity) may identify patients who are at increased risk for severe periictal hypoventilation. HCVR has not been studied previously in patients with epilepsy; therefore we evaluated a method to measure it at bedside in an epilepsy monitoring unit (EMU) and examined its relationship to postictal hypercapnia following generalized convulsive seizures (GCSs). Read More

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http://dx.doi.org/10.1111/epi.14660DOI Listing
February 2019

Curcumin reduces development of seizurelike events in the hippocampal-entorhinal cortex slice culture model for epileptogenesis.

Epilepsia 2019 Feb 12. Epub 2019 Feb 12.

Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands.

Objective: Inhibition of the mammalian target of rapamycin (mTOR) pathway could be antiepileptogenic in temporal lobe epilepsy (TLE), possibly via anti-inflammatory actions. We studied effects of the mTOR inhibitor rapamycin and the anti-inflammatory compound curcumin-also reported to inhibit the mTOR pathway-on epileptogenesis and inflammation in an in vitro organotypic hippocampal-entorhinal cortex slice culture model.

Methods: Brain slices containing hippocampus and entorhinal cortex were obtained from 6-day-old rat pups and maintained in culture for up to 3 weeks. Read More

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http://dx.doi.org/10.1111/epi.14667DOI Listing
February 2019

Risk analysis of hemorrhage in stereo-electroencephalography procedures.

Epilepsia 2019 Feb 12. Epub 2019 Feb 12.

Epilepsy Center, Neurological Institute, Cleveland Clinic, Cleveland, Ohio.

Objective: To examine the true incidence of hemorrhage related to stereo-electroencephalography (SEEG) procedures. To analyze risk factors associated with the presence of different types of hemorrhage in SEEG procedures.

Methods: This was a retrospective, single-center observational study examining every SEEG implantation performed at our center from 2009 to 2017. Read More

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http://dx.doi.org/10.1111/epi.14668DOI Listing
February 2019

Functional MRI and direct cortical stimulation: Prediction of postoperative language decline.

Epilepsia 2019 Feb 11. Epub 2019 Feb 11.

Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland.

Objective: To assess the ability of functional MRI (fMRI) to predict postoperative language decline compared to direct cortical stimulation (DCS) in epilepsy surgery patients.

Methods: In this prospective case series, 17 patients with drug-resistant epilepsy had intracranial monitoring and resection from 2012 to 2016 with 1-year follow-up. All patients completed preoperative language fMRI, mapping with DCS of subdural electrodes, pre- and postoperative neuropsychological testing for language function, and resection. Read More

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http://doi.wiley.com/10.1111/epi.14666
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http://dx.doi.org/10.1111/epi.14666DOI Listing
February 2019
2 Reads

Cannabidiol in patients with Lennox-Gastaut syndrome: Interim analysis of an open-label extension study.

Epilepsia 2019 Feb 11. Epub 2019 Feb 11.

GW Research Ltd, Cambridge, UK.

Objective: Patients with Lennox-Gastaut syndrome (LGS) who completed 1 of 2 randomized, double-blind, placebo-controlled trials of add-on cannabidiol (CBD) (GWPCARE3, NCT02224560 or GWPCARE4, NCT02224690) were invited to enroll in an open-label extension (OLE) study evaluating the long-term safety and efficacy of CBD (GWPCARE5, NCT02224573). Herein we present an interim analysis of the safety, efficacy, and patient-reported outcomes from this trial.

Methods: Patients received a pharmaceutical formulation of highly purified CBD oral solution (Epidiolex; 100 mg/mL), titrated from 2. Read More

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http://dx.doi.org/10.1111/epi.14670DOI Listing
February 2019
1 Read

A mouse model of seizures in anti-N-methyl-d-aspartate receptor encephalitis.

Epilepsia 2019 Feb 11. Epub 2019 Feb 11.

Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia.

Objective: Seizures develop in 80% of patients with anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis, and these represent a major cause of morbidity and mortality. Anti-NMDAR antibodies have been linked to memory loss in encephalitis; however, their role in seizures has not been established. We determined whether anti-NMDAR antibodies from autoimmune encephalitis patients are pathogenic for seizures. Read More

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http://dx.doi.org/10.1111/epi.14662DOI Listing
February 2019
1 Read

fMRI prediction of naming change after adult temporal lobe epilepsy surgery: Activation matters.

Epilepsia 2019 Feb 11. Epub 2019 Feb 11.

Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland.

Objective: We aimed to predict language deficits after epilepsy surgery. In addition to evaluating surgical factors examined previously, we determined the impact of the extent of functional magnetic resonance imaging (fMRI) activation that was resected on naming ability.

Method: Thirty-five adults (mean age 37. Read More

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http://dx.doi.org/10.1111/epi.14656DOI Listing
February 2019

Development of information sharing in language neocortex in childhood-onset drug-resistant epilepsy.

Epilepsia 2019 Feb 11. Epub 2019 Feb 11.

Division of Neurology, Comprehensive Epilepsy Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Objective: We studied age-related dynamics of information sharing among cortical language regions with electrocorticographic high-gamma modulation during picture-naming and story-listening tasks.

Methods: Seventeen epilepsy patients aged 4-19 years, undergoing extraoperative monitoring with left-hemispheric subdural electrodes, were included. Mutual information (MI), a nondirectional measure of shared information, between 16 pairs of cortical regions of interest, was computed from trial-averaged 70-150 Hz power modulations during language tasks. Read More

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http://dx.doi.org/10.1111/epi.14661DOI Listing
February 2019

Sensorimotor network hypersynchrony as an endophenotype in families with genetic generalized epilepsy: A resting-state functional magnetic resonance imaging study.

Epilepsia 2019 Feb 7. Epub 2019 Feb 7.

Department of Basic and Clinical Neuroscience, Institute of Psychiatry Psychology and Neuroscience, King's College London, London, UK.

Recent evidence suggests that three specific brain networks show state-dependent levels of synchronization before, during, and after episodes of generalized spike-wave discharges (GSW) in patients with genetic generalized epilepsy (GGE). Here, we investigate whether synchronization in these networks differs between patients with GGE (n = 13), their unaffected first-degree relatives (n = 17), and healthy controls (n = 18). All subjects underwent two 10-minute simultaneous electroencephalographic-functional magnetic resonance imaging (fMRI) recordings without GSW. Read More

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http://dx.doi.org/10.1111/epi.14663DOI Listing
February 2019

Antibody Prevalence in Epilepsy and Encephalopathy score: Increased specificity and applicability.

Epilepsia 2019 Feb;60(2):367-369

Department of Neurology, Mayo Clinic, Rochester, Minnesota.

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http://dx.doi.org/10.1111/epi.14649DOI Listing
February 2019

Effect of monoamine reuptake inhibition and α blockade on respiratory arrest and death following electroshock-induced seizures in mice.

Epilepsia 2019 Feb 5. Epub 2019 Feb 5.

The Iowa Neuroscience Institute, University of Iowa, Iowa City, Iowa.

Objective: Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in patients with refractory epilepsy. Although the mechanisms for SUDEP are incompletely understood, seizure-induced respiratory arrest (S-IRA) has been strongly and consistently implicated. A body of evidence indicates that serotonin (5-HT), a modulator of breathing, plays a critical role in SUDEP. Read More

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http://dx.doi.org/10.1111/epi.14652DOI Listing
February 2019

Risk factors for injury in a community-treated cohort of patients with epilepsy in Australia.

Epilepsia 2019 Feb 5. Epub 2019 Feb 5.

Department of Medicine, University of Melbourne, St Vincent's Hospital Melbourne, Melbourne, Victoria, Australia.

Objective: There remains a paucity of knowledge regarding specific epilepsy-related risk factors for accidents and injuries in people with epilepsy. Injury studies in people with epilepsy are overrepresented, with tertiary based populations that are prone to bias from severe disease. This study aims to assess the contribution of epilepsy-related risk factors to injuries in a community-based cohort. Read More

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http://dx.doi.org/10.1111/epi.14659DOI Listing
February 2019
9 Reads

Replication, reanalysis, and gene expression: ME2 and genetic generalized epilepsy.

Epilepsia 2019 Feb 4. Epub 2019 Feb 4.

The Research Institute at Nationwide Children's Hospital, Nationwide Children's Hospital, Columbus, Ohio.

Objective: Genetic generalized epilepsy (GGE) consists of epileptic syndromes with overlapping symptoms and is considered to be largely genetic. Previous cosegregation and association studies have pointed to malic enzyme 2 (ME2) as a candidate susceptibility gene for adolescent-onset GGE. In this article, we present new evidence supporting ME2's involvement in GGE. Read More

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http://dx.doi.org/10.1111/epi.14654DOI Listing
February 2019

No evidence for a BRD2 promoter hypermethylation in blood leukocytes of Europeans with juvenile myoclonic epilepsy.

Epilepsia 2019 Feb 4. Epub 2019 Feb 4.

Cologne Center for Genomics, University of Cologne, Cologne, Germany.

Juvenile myoclonic epilepsy (JME) is a common syndrome of genetic generalized epilepsies (GGEs). Linkage and association studies suggest that the gene encoding the bromodomain-containing protein 2 (BRD2) may increase risk of JME. The present methylation and association study followed up a recent report highlighting that the BRD2 promoter CpG island (CpG76) is differentially hypermethylated in lymphoblastoid cells from Caucasian patients with JME compared to patients with other GGE subtypes and unaffected relatives. Read More

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http://dx.doi.org/10.1111/epi.14657DOI Listing
February 2019
1 Read

Fenfluramine, a serotonin-releasing drug, prevents seizure-induced respiratory arrest and is anticonvulsant in the DBA/1 mouse model of SUDEP.

Epilepsia 2019 Feb 4. Epub 2019 Feb 4.

Departments of Pharmacology and Neurology, Southern Illinois University School of Medicine, Springfield, Illinois.

Objective: Prevention of sudden unexpected death in epilepsy (SUDEP) is a critical goal for epilepsy therapy. The DBA/1 mouse model of SUDEP exhibits an elevated susceptibility to seizure-induced death in response to electroconvulsive shock, hyperthermia, convulsant drug, and acoustic stimulation. The serotonin hypothesis of SUDEP is based on findings that treatments which modify serotonergic function significantly alter susceptibility to seizure-induced sudden death in several epilepsy models, including DBA/1 mice. Read More

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http://dx.doi.org/10.1111/epi.14658DOI Listing
February 2019
2 Reads

Four-dimensional functional cortical maps of visual and auditory language: Intracranial recording.

Epilepsia 2019 Feb 1;60(2):255-267. Epub 2019 Feb 1.

Department of Pediatrics, Detroit Medical Center, Children's Hospital of Michigan, Wayne State University, Detroit, Michigan.

Objective: The strength of presurgical language mapping using electrocorticography (ECoG) is its outstanding signal fidelity and temporal resolution, but the weakness includes limited spatial sampling at an individual patient level. By averaging naming-related high-gamma activity at nonepileptic regions across a large number of patients, we provided the functional cortical atlases animating the neural dynamics supporting visual-object and auditory-description naming at the whole brain level.

Methods: We studied 79 patients who underwent extraoperative ECoG recording as epilepsy presurgical evaluation, and generated time-frequency plots and animation videos delineating the dynamics of naming-related high-gamma activity at 70-110 Hz. Read More

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http://doi.wiley.com/10.1111/epi.14648
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http://dx.doi.org/10.1111/epi.14648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365188PMC
February 2019
2 Reads

Spectrum of neurodevelopmental disease associated with the GNAO1 guanosine triphosphate-binding region.

Epilepsia 2019 Jan 25. Epub 2019 Jan 25.

Epilepsy Genetics Program, Department of Neurology, Boston Children's Hospital, Boston, Massachusetts.

Objective: To characterize the phenotypic spectrum associated with GNAO1 variants and establish genotype-protein structure-phenotype relationships.

Methods: We evaluated the phenotypes of 14 patients with GNAO1 variants, analyzed their variants for potential pathogenicity, and mapped them, along with those in the literature, on a three-dimensional structural protein model.

Results: The 14 patients in our cohort, including one sibling pair, had 13 distinct, heterozygous GNAO1 variants classified as pathogenic or likely pathogenic. Read More

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http://dx.doi.org/10.1111/epi.14653DOI Listing
January 2019
1 Read

Medication treatment for attention-deficit/hyperactivity disorder and the risk of acute seizures in individuals with epilepsy.

Epilepsia 2019 Feb 25;60(2):284-293. Epub 2019 Jan 25.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Objective: Attention-deficit/hyperactivity disorder (ADHD) affects 10%-30% of individuals with epilepsy, yet concerns remain regarding the safety of ADHD medication in this group. The objective of this study was to examine the risk of acute seizures associated with ADHD medication in individuals with epilepsy.

Methods: A total of 21 557 individuals with a seizure history born between 1987 and 2003 were identified from Swedish population registers. Read More

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http://dx.doi.org/10.1111/epi.14640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365170PMC
February 2019
4.571 Impact Factor

Taurine potentiates the anticonvulsive effect of the GABA agonist muscimol and pentobarbital in the immature mouse hippocampus.

Epilepsia 2019 Jan 25. Epub 2019 Jan 25.

Institute of Physiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

Objective: The high incidence of epileptic seizures in neonates and their frequent refractoriness to pharmacologic therapies require identification of new therapeutical options. Therefore, we investigated whether the modulatory effect of taurine on γ-aminobutyric acid (GABA) receptors can enhance the anticonvulsive potential of the GABA receptor agonist muscimol and of the barbiturate pentobarbital.

Methods: We performed field potential recordings in in toto hippocampus preparations of immature (postnatal days 4-7) C57Bl/6 mouse pups. Read More

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http://dx.doi.org/10.1111/epi.14651DOI Listing
January 2019

Correction of medication nonadherence results in better seizure outcomes than dose escalation in a novel preclinical epilepsy model of adherence.

Epilepsia 2019 Jan 22. Epub 2019 Jan 22.

Department of Pharmacy, School of Pharmacy, University of Washington, Seattle, Washington.

Objective: Medication nonadherence directly contributes to poor seizure control. A lack of emphasis on correcting poor adherence and failures in patient adherence can result in unwarranted alterations to a patient's drug regimen. We have modeled nonadherent patients in an animal model of epilepsy to study how alterations to pharmacotherapy, made without consideration of a patient's adherence, result in changes to seizure control. Read More

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http://doi.wiley.com/10.1111/epi.14655
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http://dx.doi.org/10.1111/epi.14655DOI Listing
January 2019
2 Reads

Drug repurposing for Dravet syndrome in scn1Lab mutant zebrafish.

Epilepsia 2019 Feb 20;60(2):e8-e13. Epub 2019 Jan 20.

Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, Leuven, Belgium.

Dravet syndrome (DS) is a severe genetic epileptic encephalopathy with onset during the first year of life. Zebrafish models recapitulating human diseases are often used as drug discovery platforms, but also for drug repurposing testing. It was recently shown that pharmacological modulation of three serotonergic (5-HT) receptors (5-HT , 5-HT , 5-HT ) exerts antiseizure effects in a zebrafish scn1Lab mutant model of DS. Read More

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http://dx.doi.org/10.1111/epi.14647DOI Listing
February 2019
1 Read

Fifty years' follow-up of childhood epilepsy: Medical outcome, morbidity, and medication.

Epilepsia 2019 Jan 20. Epub 2019 Jan 20.

Faculty of Medicine and Health, Department of Pediatrics, Örebro University, Örebro, Sweden.

Objective: To describe the long-term prognosis of childhood epilepsy, with special emphasis on seizure remission, relapse, medication, associated neurologic impairment, mortality rate, and cause of death.

Methods: A prospective longitudinal study on a population-based total cohort of 195 children with epileptic seizures in 1962-1964. Data were collected from medical records and a questionnaire. Read More

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http://dx.doi.org/10.1111/epi.14643DOI Listing
January 2019
6 Reads

Real-time effects of interictal spikes on hippocampus and amygdala functional connectivity in unilateral temporal lobe epilepsy: An EEG-fMRI study.

Epilepsia 2019 Feb 17;60(2):246-254. Epub 2019 Jan 17.

Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Objective: To explore the real-time effects of interictal epileptiform discharges (IEDs) on hippocampus and amygdala functional connectivity (FC) in unilateral temporal lobe epilepsy (TLE).

Methods: Patients with unilateral TLE were recruited and underwent simultaneous electroencephalography-functional magnetic resonance imaging (EEG-fMRI) scanning. Simultaneous EEG was used to define the prespike (10 s before spike) and postspike (10 s after spike) periods. Read More

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http://doi.wiley.com/10.1111/epi.14646
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http://dx.doi.org/10.1111/epi.14646DOI Listing
February 2019
6 Reads
4.571 Impact Factor

Referral to evaluation for epilepsy surgery: Reluctance by epileptologists and patients.

Epilepsia 2019 Feb 17;60(2):211-219. Epub 2019 Jan 17.

Epilepsy-Center Berlin-Brandenburg, Department of Neurology, Charité-Universitätsmedizin Berlin, Berlin, Germany.

Objective: Despite the obvious advantages of resective surgery in patients with drug-resistant focal epilepsy, namely high probability of seizure freedom, decreased mortality, and increased quality of life, referral rates from physicians and approval rates by patients for presurgical assessment remain constantly low.

Methods: In the outpatient clinics of a tertiary epilepsy center, checklists were implemented asking treating epileptologists whether they recommended presurgical evaluation with noninvasive video-electroencephalographic monitoring to adult patients with drug-resistant focal epilepsy and asking respective patients whether they followed this recommendation.

Results: Of 185 eligible patients, 80 (43%) were recommended presurgical evaluation by their epileptologists, and 24 (30%) of these patients consented. Read More

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http://dx.doi.org/10.1111/epi.14641DOI Listing
February 2019
9 Reads

Safety and effectiveness of stereotactic laser ablation for epileptogenic cerebral cavernous malformations.

Epilepsia 2019 Feb 17;60(2):220-232. Epub 2019 Jan 17.

Department of Neurological Surgery, Emory University School of Medicine, Atlanta, Georgia.

Objective: Magnetic resonance (MR) thermography-guided laser interstitial thermal therapy, or stereotactic laser ablation (SLA), is a minimally invasive alternative to open surgery for focal epilepsy caused by cerebral cavernous malformations (CCMs). We examined the safety and effectiveness of SLA of epileptogenic CCMs.

Methods: We retrospectively analyzed 19 consecutive patients who presented with focal seizures associated with a CCM. Read More

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http://doi.wiley.com/10.1111/epi.14634
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http://dx.doi.org/10.1111/epi.14634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365175PMC
February 2019
8 Reads

Blood markers of cardiac stress after generalized convulsive seizures.

Epilepsia 2019 Feb 15;60(2):201-210. Epub 2019 Jan 15.

Department of Epileptology, University Hospital Bonn, Bonn, Germany.

Objective: Generalized convulsive seizures (GCS) are associated with high demands on the cardiovascular system, thereby facilitating cardiac complications. To investigate occurrence, influencing factors, and extent of cardiac stress or injury, the alterations and time course of the latest generation of cardiac blood markers were investigated after documented GCS.

Methods: Adult patients with refractory epilepsy who underwent video-electroencephalography (EEG) monitoring along with simultaneous one-lead electrocardiography (ECG) recordings were included. Read More

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http://doi.wiley.com/10.1111/epi.14637
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http://dx.doi.org/10.1111/epi.14637DOI Listing
February 2019
3 Reads

Prevalence and trajectories of depressive symptoms among mothers of children with newly diagnosed epilepsy: A longitudinal 10-year study.

Epilepsia 2019 Feb 15;60(2):358-366. Epub 2019 Jan 15.

Department of Epidemiology and Biostatistics, Western University, London, Ontario, Canada.

Objective: Parental depression significantly impacts children's health and well-being. This study aimed to (1) estimate the prevalence of depressive symptoms, at six time points, among mothers over the first 10 years after their child was diagnosed with epilepsy; (2) identify trajectories of maternal depressive symptoms over time; and (3) identify baseline factors associated with each trajectory.

Methods: Data came from the Health-Related Quality of Life in Children with Epilepsy Study (HERQULES), a Canada-wide prospective cohort study. Read More

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http://dx.doi.org/10.1111/epi.14638DOI Listing
February 2019
2 Reads

Tonic electromyographic activity following bilateral tonic-clonic seizures is associated with periictal respiratory dysfunction and postictal generalized EEG suppression.

Epilepsia 2019 Feb 10;60(2):268-274. Epub 2019 Jan 10.

Department of Neurology, University of California Davis, Davis, California.

Objective: No biomarkers reliably predict risk for sudden unexpected death in epilepsy (SUDEP). Postictal generalized electroencephalography (EEG) suppression (PGES) is a possible biomarker for SUDEP risk. However, its utility in predicting SUDEP remains uncertain. Read More

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http://dx.doi.org/10.1111/epi.14632DOI Listing
February 2019
2 Reads

Comparative efficacy of valnoctamide and sec-butylpropylacetamide (SPD) in terminating nerve agent-induced seizures in pediatric rats.

Epilepsia 2019 Feb 7;60(2):315-321. Epub 2019 Jan 7.

Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.

Objectives: Children and adults are likely to be among the casualties in a civilian nerve agent exposure. This study evaluated the efficacy of valnoctamide (racemic-VCD), sec-butylpropylacetamide (racemic-SPD), and phenobarbital for stopping nerve agent seizures in both immature and adult rats.

Methods: Female and male postnatal day (PND) 21, 28, and 70 (adult) rats, previously implanted with electroencephalography (EEG) electrodes were exposed to seizure-inducing doses of the nerve agents sarin or VX and EEG was recorded continuously. Read More

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http://dx.doi.org/10.1111/epi.14630DOI Listing
February 2019
3 Reads

Corrigendum.

Authors:

Epilepsia 2019 Jan 6;60(1):187. Epub 2018 Dec 6.

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http://dx.doi.org/10.1111/epi.14617DOI Listing
January 2019
1 Read

Seizure-induced microvascular injury is associated with impaired neurovascular coupling and blood-brain barrier dysfunction.

Epilepsia 2019 Feb 4;60(2):322-336. Epub 2019 Jan 4.

Department of Medical Neuroscience, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.

Objective: Blood-brain barrier (BBB) impairment, redistribution of pericytes, and disturbances in cerebral blood flow may contribute to the increased seizure propensity and neurological comorbidities associated with epilepsy. However, despite the growing evidence of postictal disturbances in microcirculation, it is not known how recurrent seizures influence pericytic membrane currents and subsequent vasodilation.

Methods: Here, we investigated successive changes in capillary neurovascular coupling and BBB integrity during recurrent seizures induced by 4-aminopyridine or low-Mg conditions. Read More

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http://dx.doi.org/10.1111/epi.14631DOI Listing
February 2019
3 Reads

Spontaneous epileptiform activity in a rat model of bilateral subcortical band heterotopia.

Epilepsia 2019 Feb 30;60(2):337-348. Epub 2018 Dec 30.

Neurobiology Institute of the Mediterranean (INMED), Aix-Marseille University, French National Institute of Health and Medical Research (INSERM) UMR1249, Marseille, France.

Objective: Malformations of cortical development are common causes of intellectual disability and epilepsy, yet there is a crucial lack of relevant preclinical models associating seizures and cortical malformations. Here, we describe a novel rat model with bilateral subcortical band heterotopia (SBH) and examine whether this model develops spontaneous epileptic seizures.

Methods: To generate bilateral SBH in rats, we combined RNAi-mediated knockdown of Dcx and in utero electroporation with a tripolar electrode configuration enabling simultaneous transfection of the two brain hemispheres. Read More

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http://dx.doi.org/10.1111/epi.14633DOI Listing
February 2019
1 Read

Cannabidiol reduces seizures and associated behavioral comorbidities in a range of animal seizure and epilepsy models.

Epilepsia 2019 Feb 26;60(2):303-314. Epub 2018 Dec 26.

School of Pharmacy, University of Reading, Reading, United Kingdom.

Objective: Epilepsy is a progressive neurological disease characterized by recurrent seizures and behavioral comorbidities. We investigated the antiseizure effect of cannabidiol (CBD) in a battery of acute seizure models. Additionally, we defined the disease-modifying potential of chronic oral administration of CBD on associated comorbidities in the reduced intensity status epilepticus-spontaneous recurrent seizures (RISE-SRS) model of temporal lobe epilepsy (TLE). Read More

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http://dx.doi.org/10.1111/epi.14629DOI Listing
February 2019
2 Reads

Localization yield and seizure outcome in patients undergoing bilateral SEEG exploration.

Epilepsia 2019 Jan 26;60(1):107-120. Epub 2018 Dec 26.

Epilepsy Center, Cleveland Clinic Foundation, Cleveland, Ohio.

Objective: We aimed to determine the rates and predictors of resection and seizure freedom after bilateral stereo-electroencephalography (SEEG) implantation.

Methods: We reviewed 184 patients who underwent bilateral SEEG implantation (2009-2015). Noninvasive and invasive evaluation findings were collected. Read More

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http://doi.wiley.com/10.1111/epi.14624
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http://dx.doi.org/10.1111/epi.14624DOI Listing
January 2019
23 Reads

Illness severity scoring in status epilepticus-When STESS meets APACHE II, SAPS II, and SOFA.

Epilepsia 2019 Feb 25;60(2):189-200. Epub 2018 Dec 25.

Clinic for Intensive Care Medicine, University Hospital Basel, Basel, Switzerland.

Objective: To characterize a critically ill cohort with status epilepticus (SE) by the illness severity scoring systems SAPS II (Simplified Acute Physiology Score II), APACHE II (Acute Physiology and Chronic Health Evaluation II), and SOFA (Sequential Organ Failure Assessment), and to compare their performance with the STESS (Status Epilepticus Severity Score) for outcome prediction.

Methods: The prospective cohort study was carried out at the University Hospital Basel, a Swiss tertiary academic medical care center. Consecutive adult SE patients hospitalized in the intensive care units from 2011 to 2016 were included. Read More

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http://doi.wiley.com/10.1111/epi.14623
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http://dx.doi.org/10.1111/epi.14623DOI Listing
February 2019
8 Reads
4.571 Impact Factor

Do neurologists agree in diagnosing drug resistance in adults with focal epilepsy?

Epilepsia 2019 Jan 25;60(1):175-183. Epub 2018 Dec 25.

Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia and Clinical Trial Center, IRCCS Mondino Foundation, Pavia, Italy.

Objective: To evaluate interrater agreement in categorizing treatment outcomes and drug responsiveness status according to the International League Against Epilepsy (ILAE) definition of drug-resistant epilepsy.

Methods: A total of 1053 adults with focal epilepsy considered by the investigators to meet ILAE criteria for drug resistance were enrolled consecutively at 43 centers and followed up prospectively for 18-34 months. Treatment outcomes for all antiepileptic drugs (AEDs) used up to enrollment (retrospective assessment), and on an AED newly introduced at enrollment, were categorized by individual investigators and by 2 rotating members of a 16-member expert panel (EP) that reviewed the patient records independently. Read More

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http://doi.wiley.com/10.1111/epi.14622
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http://dx.doi.org/10.1111/epi.14622DOI Listing
January 2019
7 Reads

Long-term cannabidiol treatment in patients with Dravet syndrome: An open-label extension trial.

Epilepsia 2019 Feb 23;60(2):294-302. Epub 2018 Dec 23.

GW Research Ltd, Cambridge, UK.

Objective: Add-on cannabidiol (CBD) significantly reduced seizures associated with Dravet syndrome (DS) in a randomized, double-blind, placebo-controlled trial: GWPCARE1 Part B (NCT02091375). Patients who completed GWPCARE1 Part A (NCT02091206) or Part B, or a second placebo-controlled trial, GWPCARE2 (NCT02224703), were invited to enroll in a long-term open-label extension trial, GWPCARE5 (NCT02224573). We present an interim analysis of the safety, efficacy, and patient-reported outcomes from GWPCARE5. Read More

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http://dx.doi.org/10.1111/epi.14628DOI Listing
February 2019
2 Reads

Medical health care utilization cost of patients presenting with psychogenic nonepileptic seizures.

Epilepsia 2019 Feb 21;60(2):349-357. Epub 2018 Dec 21.

Department of Neurology, Monash Medical Centre, Clayton, Victoria, Australia.

Objective: To investigate the health care utilization cost of patients presenting with psychogenic nonepileptic seizures (PNES) to a tertiary hospital in Australia.

Methods: This is a retrospective analysis of adult patients with PNES based on video-electroencephalographic confirmation over a 5-year period. We used an itemized list to collect detailed health care utilization data. Read More

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http://dx.doi.org/10.1111/epi.14625DOI Listing
February 2019
2 Reads

Infections and risk of epilepsy in children and young adults: A nationwide study.

Epilepsia 2019 Feb 21;60(2):275-283. Epub 2018 Dec 21.

Department of Neurology, Aarhus University Hospital, Aarhus, Denmark.

Objective: The development of epilepsy has been linked to infections of the central nervous system, but recently also to infections and inflammation outside of the central nervous system. Thus we investigated the association between infections and the risk of subsequent epilepsy.

Methods: This was a Danish nationwide population-based cohort study comprising a total of 1 938 555 individuals born between 1982 and 2012. Read More

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http://doi.wiley.com/10.1111/epi.14626
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http://dx.doi.org/10.1111/epi.14626DOI Listing
February 2019
7 Reads

Postictal clinical and electroencephalographic activity following intracranially recorded bilateral tonic-clonic seizures.

Epilepsia 2019 Jan 21;60(1):74-84. Epub 2018 Dec 21.

Department of Neurology, Columbia University Medical Center, New York, New York.

Objective: The dynamics of the postictal period, which may demonstrate such dramatic clinical phenomena as focal neurological deficits, prolonged coma and immobility, and even sudden death, are poorly understood. We sought to classify and characterize postictal phases of bilateral tonic-clonic seizures based on electroencephalographic (EEG) criteria and associated clinical features.

Methods: We performed a detailed electroclinical evaluation of the postictal period in a series of 31 bilateral tonic-clonic seizures in 16 patients undergoing epilepsy surgery evaluations for focal pharmacoresistant epilepsy with intracranial electrodes and time-locked video. Read More

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http://dx.doi.org/10.1111/epi.14621DOI Listing
January 2019
1 Read

Differences in pediatric and adult epilepsy surgery: A comparison at one center from 1990 to 2014.

Epilepsia 2019 Feb 21;60(2):233-245. Epub 2018 Dec 21.

Bethel Epilepsy Center, Mara Hospital, Bielefeld, Germany.

Objective: Surgical volumes at large epilepsy centers are decreasing. Pediatric cohorts, however, show a trend toward more resections and superior outcome. Differences in pediatric and adult epilepsy surgery were investigated in our cohort. Read More

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http://dx.doi.org/10.1111/epi.14627DOI Listing
February 2019
1 Read

Two main focal seizure patterns revealed by intracerebral electroencephalographic biomarker analysis.

Epilepsia 2019 Jan 22;60(1):96-106. Epub 2018 Nov 22.

Claudio Munari Epilepsy Surgery Center, Niguarda Hospital, Milan, Italy.

Objective: Long-term recording with intracerebral electrodes is commonly utilized to identify brain areas responsible for seizure generation (epileptogenic zone) and to tailor therapeutic surgical resections in patients with focal drug-resistant epilepsy. This invasive diagnostic procedure generates a wealth of data that contribute to understanding human epilepsy. We analyze intracerebral signals to identify and classify focal ictal patterns. Read More

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http://doi.wiley.com/10.1111/epi.14610
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http://dx.doi.org/10.1111/epi.14610DOI Listing
January 2019
7 Reads

Prolonged status epilepticus: Early recognition and prediction of full recovery in a 12-year cohort.

Epilepsia 2019 Jan 22;60(1):42-52. Epub 2018 Nov 22.

Department of Neurology, University Hospital Basel, Basel, Switzerland.

Objectives: Early identification of patients who are at risk of prolonged status epilepticus (SE) and patients with high chances of full recovery despite prolonged SE may urge clinicians to intensify treatment rather than to withdraw care. We aimed to develop prediction models based on readily available clinical parameters to predict prolonged SE at seizure onset and to identify patients with high chances for full recovery.

Methods: From 2005 to 2016, all adult SE patients treated at the University Hospital Basel, a Swiss medical care center, were included. Read More

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http://dx.doi.org/10.1111/epi.14603DOI Listing
January 2019
5 Reads
4.571 Impact Factor

Postictal electroencephalographic (EEG) suppression: A stereo-EEG study of 100 focal to bilateral tonic-clonic seizures.

Epilepsia 2019 Jan 22;60(1):63-73. Epub 2018 Nov 22.

Inserm, INS, Brain Dynamics Institute, Aix Marseille University, Marseille, France.

Objectives: We aimed to describe intracerebral aspects of postictal generalized electroencephalography suppression (PGES) following focal to bilateral tonic-clonic ("secondarily generalized tonic-clonic") seizures (GTCS) recorded using stereoelectroencephalographic (SEEG), and to correlate these with electroclinical features.

Methods: Three independent observers scored semiologic and SEEG features. Patient and epilepsy characteristics were collected. Read More

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http://doi.wiley.com/10.1111/epi.14601
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http://dx.doi.org/10.1111/epi.14601DOI Listing
January 2019
6 Reads

Neurocognition in childhood epilepsy: Impact on mortality and complete seizure remission 50 years later.

Epilepsia 2019 Jan 22;60(1):131-138. Epub 2018 Nov 22.

Department of Neurology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin.

Objective: To study associations of the severity of impairment in childhood neurocognition (NC) with long-term mortality and complete seizure remission.

Methods: A population-based cohort of 245 subjects with childhood onset epilepsy was followed up for 50 years (median = 45, range = 2-50). Childhood NC before age 18 years was assessed as a combination of formal intelligence quotient scores and functional criteria (school achievement, working history, and psychoneurological development). Read More

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http://dx.doi.org/10.1111/epi.14606DOI Listing
January 2019
2 Reads

Diagnostic exome sequencing in 100 consecutive patients with both epilepsy and intellectual disability.

Epilepsia 2019 Jan 7;60(1):155-164. Epub 2018 Dec 7.

Department of Human Genetics, Maastricht University Medical Center, Maastricht, The Netherlands.

Objective: Epilepsy is highly prevalent among patients with intellectual disability (ID), and seizure control is often difficult. Identification of the underlying etiology in this patient group is important for daily clinical care. We assessed the diagnostic yield of whole exome sequencing (WES). Read More

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http://dx.doi.org/10.1111/epi.14618DOI Listing
January 2019
2 Reads

Quantitative analysis and EEG markers of KCNT1 epilepsy of infancy with migrating focal seizures.

Epilepsia 2019 Jan 7;60(1):20-32. Epub 2018 Dec 7.

INSERM Unit U1129 Infantile Epilepsies and Brain Plasticity, University Paris Descartes, Sorbonne Paris Cité, Paris, France.

Objective: We aimed to characterize epilepsy of infancy with migrating focal seizures (EIMFS), a rare, severe early onset developmental epilepsy related to KCNT1 mutation, and to define specific electroencephalography (EEG) markers using EEG quantitative analysis. The ultimate goal would be to improve early diagnosis and to better understand seizure onset and propagation of EIMFS as compared to other early onset developmental epilepsy.

Methods: EEG of 7 EIMFS patients with KCNT1 mutations (115 seizures) and 17 patients with other early onset epilepsies (30 seizures) was included in this study. Read More

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http://dx.doi.org/10.1111/epi.14605DOI Listing
January 2019
2 Reads