11,258 results match your criteria Epilepsia[Journal]


Reproducibility of interictal spike propagation in children with refractory epilepsy.

Epilepsia 2019 Apr 21. Epub 2019 Apr 21.

School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, New York.

Objective: Interictal spikes are a characteristic feature of invasive electroencephalography (EEG) recordings in children with refractory epilepsy. Spikes frequently co-occur across multiple brain regions with discernable latencies, suggesting that spikes can propagate through distributed neural networks. The purpose of this study was to examine the long-term reproducibility of spike propagation patterns over hours to days of interictal recording. Read More

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http://dx.doi.org/10.1111/epi.14720DOI Listing

First-in-man study of ACT-709478, a novel selective triple T-type calcium channel blocker.

Epilepsia 2019 Apr 20. Epub 2019 Apr 20.

Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland.

Objective: Increased activity of T-type Ca channels is linked to idiopathic generalized epilepsies, thus blocking these channels may be a new treatment option. ACT-709478 is an orally available triple T-type Ca channel blocker. The aim of this first-in-man study was to investigate the pharmacokinetics, pharmacodynamics, tolerability, and safety of single doses of ACT-709478 in healthy subjects. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/epi.14732
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http://dx.doi.org/10.1111/epi.14732DOI Listing
April 2019
1 Read

Randomized controlled trial of motivational interviewing for psychogenic nonepileptic seizures.

Epilepsia 2019 Apr 13. Epub 2019 Apr 13.

Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Objective: We conducted a randomized controlled trial of motivational interviewing (MI) as an intervention to improve psychotherapy adherence and outcomes, including frequency of psychogenic nonepileptic seizures (PNES), quality of life, and emergency department utilization, among participants with PNES.

Methods: Sixty participants were randomized to receive either psychotherapy alone or MI plus psychotherapy. Participants and therapists were contacted at 16-week follow-up. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/epi.14728
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http://dx.doi.org/10.1111/epi.14728DOI Listing
April 2019
2 Reads

Surgical outcomes and prognostic factors of drug-resistant epilepsy secondary to encephalomalacia.

Epilepsia 2019 Apr 13. Epub 2019 Apr 13.

Beijing Key Laboratory of Epilepsy, Sanbo Brain Hospital, Capital Medical University, Beijing, China.

Objective: To evaluate long-term outcomes and prognostic factors in patients who underwent surgical resection for drug-resistant epilepsy secondary to encephalomalacia.

Methods: A total of 143 patients with drug-resistant epilepsy who underwent surgical resection with a follow-up of at least 5 years were included. Seizure outcomes were evaluated based on the International League Against Epilepsy classification. Read More

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http://dx.doi.org/10.1111/epi.14733DOI Listing

Burden and epidemiology of status epilepticus in infants, children, and adolescents: A population-based study on German health insurance data.

Epilepsia 2019 Apr 13. Epub 2019 Apr 13.

Epilepsy Center Frankfurt Rhine-Main and Department of Neurology, Goethe-University, Frankfurt am Main, Germany.

Objective: Status epilepticus (SE) is an important medical emergency condition with particularly unfavorable outcome in refractory and superrefractory SE (SRSE). The economic impact of SE and especially of SRSE in the pediatric population remains unclear. We aimed to determine the burden of illness of SE in a pediatric patient population. Read More

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http://dx.doi.org/10.1111/epi.14729DOI Listing
April 2019
1 Read

The effects of valproic acid on early pregnancy human placentas: Pilot ex vivo analysis in cultured placental villi.

Epilepsia 2019 Apr 13. Epub 2019 Apr 13.

Institute for Drug Research, School of Pharmacy, Hebrew University of Jerusalem, Jerusalem, Israel.

Valproic acid is an established structural and neurodevelopmental teratogen. Recently, we demonstrated that valproate alters the barrier function of perfused term human placentas. Here, we conducted a pilot study to evaluate the effects of subchronic valproate exposure on carrier expression in cultured placental villous explants from early human pregnancies. Read More

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http://dx.doi.org/10.1111/epi.14721DOI Listing
April 2019
1 Read

Nonadherence to treatment regimens in epilepsy from the patient's perspective and predisposing factors: Differences between intentional and unintentional lack of adherence.

Epilepsia 2019 Apr 13. Epub 2019 Apr 13.

Division of Clinical Neuroscience, The National Center for Epilepsy, Oslo University Hospital, Baerum, Norway.

Nonadherence to recommended antiepileptic drug (AED) treatment regimens can result in seizure relapse with increased health risks. Nonadherence can be unintentional (eg, patients forget to take a dose), or intentional, when patients consciously decide not to follow the agreed AED treatment regimen. We aimed to determine the extent to which Norwegian patients with epilepsy (PWEs) report taking their AED differently from prescribed, either intentionally or unintentionally, and to identify risk factors for either form of nonadherence. Read More

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http://dx.doi.org/10.1111/epi.14734DOI Listing
April 2019
1 Read

PRRT2 missense mutations cluster near C-terminus and frequently lead to protein mislocalization.

Epilepsia 2019 Apr 13. Epub 2019 Apr 13.

Institute of Brain Science, School of Medicine, National Yang-Ming University, Taipei, Taiwan.

Objective: Variants in human PRRT2 cause paroxysmal kinesigenic dyskinesia (PKD) and other neurological disorders. Most reported variants resulting in truncating proteins failed to localize to cytoplasmic membrane. The present study identifies novel PRRT2 variants in PKD and epilepsy patients and evaluates the functional consequences of PRRT2 missense variations. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/epi.14725
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http://dx.doi.org/10.1111/epi.14725DOI Listing
April 2019
8 Reads

Epilepsy and seizures in young people with 22q11.2 deletion syndrome: Prevalence and links with other neurodevelopmental disorders.

Epilepsia 2019 Apr 11. Epub 2019 Apr 11.

Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Cardiff, UK.

Objective: The true prevalence of epileptic seizures and epilepsy in 22q11.2 deletion syndrome (22q11.2DS) is unknown, because previous studies have relied on historical medical record review. Read More

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http://dx.doi.org/10.1111/epi.14722DOI Listing
April 2019
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Determinants of IQ outcome after focal epilepsy surgery in childhood: A longitudinal case-control neuroimaging study.

Epilepsia 2019 Apr 10. Epub 2019 Apr 10.

Developmental Neurosciences Programme, Great Ormond Street Institute of Child Health, University College London, London, UK.

Objective: Intelligence quotient (IQ) outcomes after pediatric epilepsy surgery show significant individual variation. Clinical factors such as seizure cessation or antiepileptic medication discontinuation have been implicated, but do not fully account for the heterogeneity seen. Less is known about the impact of neurobiological factors, such as brain development and resection location. Read More

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http://dx.doi.org/10.1111/epi.14707DOI Listing
April 2019
1 Read

The spectrum of intermediate SCN8A-related epilepsy.

Epilepsia 2019 Apr 10. Epub 2019 Apr 10.

Department of Epilepsy Genetics and Personalized Treatment, Danish Epilepsy Center Filadelfia, Dianalund, Denmark.

Objective: Pathogenic variants in SCN8A have been associated with a wide spectrum of epilepsy phenotypes, ranging from benign familial infantile seizures (BFIS) to epileptic encephalopathies with variable severity. Furthermore, a few patients with intellectual disability (ID) or movement disorders without epilepsy have been reported. The vast majority of the published SCN8A patients suffer from severe developmental and epileptic encephalopathy (DEE). Read More

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http://dx.doi.org/10.1111/epi.14705DOI Listing
April 2019
4 Reads

Weaning from antiseizure drugs after new onset status epilepticus.

Epilepsia 2019 Apr 8. Epub 2019 Apr 8.

Department of Neurology, Mayo Clinic, Rochester, Minnesota.

Objective: In patients with status epilepticus (SE) without prior epilepsy, there are limited data on the safety of discontinuing antiseizure drugs (ASDs) after seizure control. We aimed to describe seizure recurrence when weaning from ASDs following new onset SE (NOSE).

Methods: Retrospective review of adult patients with NOSE admitted to Mayo Clinic, Rochester, Minnesota between January 1, 1990 and December 31, 2015 was performed. Read More

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http://dx.doi.org/10.1111/epi.14730DOI Listing
April 2019
1 Read

Targeted hippocampal GABA neuron ablation by Stable Substance P-saporin causes hippocampal sclerosis and chronic epilepsy in rats.

Epilepsia 2019 Apr 8. Epub 2019 Apr 8.

Neuroscience Institute, Morehouse School of Medicine, Atlanta, Georgia.

Cryptogenic temporal lobe epilepsy develops in the absence of identified brain injuries, infections, or structural malformations, and in these cases, an unidentified pre-existing abnormality may initiate febrile seizures, hippocampal sclerosis, and epilepsy. Although a role for GABAergic dysfunction in epilepsy is intuitively obvious, no causal relationship has been established. In this study, hippocampal GABA neurons were targeted for selective elimination to determine whether a focal hippocampal GABAergic defect in an otherwise normal brain can initiate cryptogenic temporal lobe epilepsy with hippocampal sclerosis. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/epi.14723
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http://dx.doi.org/10.1111/epi.14723DOI Listing
April 2019
8 Reads

Morphometric MRI findings challenge the concept of the "unaffected" hemisphere in Rasmussen encephalitis.

Epilepsia 2019 Apr 8. Epub 2019 Apr 8.

Department of Epileptology, University of Bonn Medical Center, Bonn, Germany.

Rasmussen encephalitis (RE) is an immune-mediated brain disease with progressive unihemispheric atrophy. Although it is regarded as a strictly one-sided pathology, volumetric magnetic resonance imaging (MRI) studies have revealed atrophy in the so-called unaffected hemisphere. In contrast to previous studies, we hypothesized that the contralesional hemisphere would show increased gray matter volume in response to the ipsilesional atrophy. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/epi.14702
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http://dx.doi.org/10.1111/epi.14702DOI Listing
April 2019
4 Reads

Duration of therapeutic coma and outcome of refractory status epilepticus.

Epilepsia 2019 Apr 7. Epub 2019 Apr 7.

Department of Neurology/Epilepsy Center, University of Alabama at Birmingham, Birmingham, Alabama.

Objective: Examine the association of duration of therapeutic coma (TC) with seizure recurrence, morbidity, and mortality in refractory status epilepticus (RSE). Define an optimal window for TC that provides sustained seizure control and minimizes complications.

Methods: Retrospective, observational cohort study involving patients who presented with RSE to the University of Alabama at Birmingham or the University of California at San Francisco from 2010 to 2016. Read More

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http://dx.doi.org/10.1111/epi.14706DOI Listing

The Epilepsy Genetics Initiative: Systematic reanalysis of diagnostic exomes increases yield.

Authors:

Epilepsia 2019 Apr 5. Epub 2019 Apr 5.

Columbia University Irving Medical Center, New York, New York.

Objective: The Epilepsy Genetics Initiative (EGI) was formed in 2014 to create a centrally managed database of clinically generated exome sequence data. EGI performs systematic research-based reanalysis to identify new molecular diagnoses that were not possible at the time of initial sequencing and to aid in novel gene discovery. Herein we report on the efficacy of this approach 3 years after inception. Read More

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http://dx.doi.org/10.1111/epi.14698DOI Listing
April 2019
3 Reads

A single-center, open-label positron emission tomography study to evaluate brivaracetam and levetiracetam synaptic vesicle glycoprotein 2A binding in healthy volunteers.

Epilepsia 2019 Mar 29. Epub 2019 Mar 29.

Department of Radiology and Biomedical Imaging, Positron Emission Tomography Center, Yale University, New Haven, Connecticut.

Objective: Brivaracetam (BRV) and levetiracetam (LEV) are antiepileptic drugs that bind synaptic vesicle glycoprotein 2A (SV2A). In vitro and in vivo animal studies suggest faster brain penetration and SV2A occupancy (SO) after dosing with BRV than LEV. We evaluated human brain penetration and SO time course of BRV and LEV at therapeutically relevant doses using the SV2A positron emission tomography (PET) tracer C-UCB-J (EP0074; NCT02602860). Read More

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http://dx.doi.org/10.1111/epi.14701DOI Listing
March 2019
1 Read
4.571 Impact Factor

Critique of the 2017 epileptic seizure and epilepsy classifications.

Epilepsia 2019 Mar 28. Epub 2019 Mar 28.

Neurology Department and Grenoble Institute of Neurosciences, National Institute of Health and Medical Research U-1216, Grenoble Alpes University Hospital, Grenoble, France.

This article critiques the International League Against Epilepsy (ILAE) 2015-2017 classifications of epilepsy, epileptic seizures, and status epilepticus. It points out the following shortcomings of the ILAE classifications: (1) they mix semiological terms with epileptogenic zone terminology; (2) simple and widely accepted terminology has been replaced by complex terminology containing less information; (3) seizure evolution cannot be described in any detail; (4) in the four-level epilepsy classification, level two (epilepsy category) overlaps almost 100% with diagnostic level one (seizure type); and (5) the design of different classifications with distinct frameworks for newborns, adults, and patients in status epilepticus is confusing. The authors stress the importance of validating the new ILAE classifications and feel that the decision of Epilepsia to accept only manuscripts that use the ILAE classifications is premature and regrettable. Read More

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http://dx.doi.org/10.1111/epi.14699DOI Listing
March 2019
1 Read

Identifying patients who will not reachieve remission after breakthrough seizures.

Epilepsia 2019 Apr 22;60(4):774-782. Epub 2019 Mar 22.

Department of Biostatistics, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.

Objective: We aim to identify people with epilepsy who are unlikely to reachieve a 12-month remission within 2 years after experiencing a breakthrough seizure following an initial 12-month remission.

Methods: We apply a novel longitudinal discriminant approach to data from the Standard and New Antiepileptic Drugs study to dynamically predict the risk of a patient not achieving a second remission after a breakthrough seizure by combining both baseline covariates (collected at the time of breakthrough seizure) and follow-up data.

Results: The model classifies 83% of patients. Read More

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http://dx.doi.org/10.1111/epi.14697DOI Listing
April 2019
4 Reads

Extrasynaptic γ-aminobutyric acid type A receptor-mediated sex differences in the antiseizure activity of neurosteroids in status epilepticus and complex partial seizures.

Epilepsia 2019 Apr 20;60(4):730-743. Epub 2019 Mar 20.

Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University Health Science Center, Bryan, Texas.

Objective: Sex differences are evident in the antiseizure activity of neurosteroids; however, the potential mechanisms remain unclear. In this study, we sought to determine whether differences in target extrasynaptic δ-subunit γ-aminobutyric acid type A (GABA-A) receptor expression and function underlie the sex differences in seizure susceptibility and the antiseizure activity of neurosteroids.

Methods: Sex differences in seizure susceptibility and protective activity of three distinct neurosteroids-allopregnanolone (AP), androstanediol (AD), and ganaxolone-were evaluated in the pilocarpine model of status epilepticus (SE) and kindling seizure test in mice. Read More

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http://dx.doi.org/10.1111/epi.14693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447432PMC
April 2019
1 Read

Neuroimaging and connectomics of drug-resistant epilepsy at multiple scales: From focal lesions to macroscale networks.

Epilepsia 2019 Apr 19;60(4):593-604. Epub 2019 Mar 19.

Multimodal Imaging and Connectome Analysis Lab, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.

Epilepsy is among the most common chronic neurologic disorders, with 30%-40% of patients having seizures despite antiepileptic drug treatment. The advent of brain imaging and network analyses has greatly improved the understanding of this condition. In particular, developments in magnetic resonance imaging (MRI) have provided measures for the noninvasive characterization and detection of lesions causing epilepsy. Read More

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http://dx.doi.org/10.1111/epi.14688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447443PMC
April 2019
1 Read

Daylight saving time transitions are not associated with increased seizure incidence.

Epilepsia 2019 Apr 19;60(4):764-773. Epub 2019 Mar 19.

Division of Epilepsy, Beth Israel Deaconess Medical Center, Harvard University, Boston, Massachusetts.

Objective: Given the known association of daylight saving time (DST) transitions with increased risk of accidents, heart attack, and stroke, we aimed to determine whether seizures, which are reportedly influenced by sleep and circadian disruption, also increased in frequency following the transition into DST.

Methods: Using Seizure Tracker's self-reported data from 12 401 individuals from 2008-2016, 932 717 seizures were assessed for changes in incidence in relation to DST transitions. Two methods of standardization-z scores and unit-scaled rate ratios (RRs)-were used to compare seizure propensities following DST transitions to other time periods. Read More

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http://dx.doi.org/10.1111/epi.14696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447440PMC
April 2019
2 Reads

Hippocampal atrophy disrupts the language network but not hemispheric language lateralization.

Epilepsia 2019 Apr 15;60(4):744-755. Epub 2019 Mar 15.

Neuroimaging Laboratory, Department of Neurology, University of Campinas, Campinas, SP, Brazil.

Objective: It is still unclear how temporal lobe epilepsy (TLE) with and without hippocampal atrophy (HA) affects cortical language distribution. We aimed to investigate the role of the hippocampus on language lateralization, activation pattern, and functional connectivity (FC) in patients with TLE.

Methods: We investigated 93 patients with TLE-divided into right HA (RHA), left HA (LHA), and negative magnetic resonance imaging (MRI) (non-HA)-and 101 controls using a semantic-language functional MRI (fMRI) task and the Boston Naming Test (BNT). Read More

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http://dx.doi.org/10.1111/epi.14694DOI Listing
April 2019
1 Read

Recent patterns of vagal nerve stimulator use in the United States: Is there a racial disparity?

Epilepsia 2019 Apr 15;60(4):756-763. Epub 2019 Mar 15.

Department of Neurology, University of California, San Francisco, San Francisco, California.

Objective: Patients with refractory epilepsy are at a high risk of complications but may not receive the same level of care across racial groups. We aimed to ascertain racial inequalities and trends in the use of a vagal nerve stimulator (VNS) among adult patients with refractory epilepsy.

Methods: A total of 24 159 adults (18 years and older) with refractory epilepsy from the National Inpatient Sample between the years 2006 and 2014 were included in this analysis. Read More

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http://dx.doi.org/10.1111/epi.14695DOI Listing
April 2019
5 Reads

Efficacy and safety of perampanel in generalized and focal to bilateral tonic-clonic seizures: A comparative study of Asian and non-Asian populations.

Epilepsia 2019 Mar;60 Suppl 1:47-59

Eisai Singapore Pte. Ltd., Singapore.

Perampanel is an approved adjunctive treatment for focal seizures with or without focal to bilateral tonic-clonic (FBTC) seizures and generalized tonic-clonic (GTC) seizures. We compared efficacy and safety of perampanel vs placebo in Asian and non-Asian populations in a post hoc analysis of pooled data from 5 randomized phase 3 studies. Patients (≥12 years old) with focal + FBTC seizures received perampanel 2, 4, 8, or 12 mg or placebo; patients with GTC seizures received perampanel 8 mg or placebo (titration: 4-6 weeks; maintenance: 13 weeks). Read More

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http://dx.doi.org/10.1111/epi.14644DOI Listing
March 2019
3 Reads
4.571 Impact Factor

A post hoc analysis of the long-term safety and efficacy of perampanel in Asian patients with epilepsy.

Epilepsia 2019 Mar;60 Suppl 1:60-67

Eisai Singapore Pte. Ltd., Singapore.

This post hoc analysis assessed the long-term safety, tolerability, and efficacy of perampanel in Asian patients with refractory focal seizures; an additional analysis assessed the effect of perampanel on focal impaired awareness seizures (FIAS) with focal to bilateral tonic-clonic (FBTC) seizures. In this subanalysis, data from Asian patients ≥12 years of age who had focal seizures with FBTC seizures despite taking one to 3 concomitant antiepileptic drugs at baseline, and who had entered either the long-term extension phase of 3 phase-3 perampanel trials (study 307) or the 10-week extension phase of study 335, were analyzed for the effect of perampanel on duration of exposure, safety, and seizure outcomes. Of 874 Asian patients included in the analysis, 205 had previously received placebo during the double-blind phase-3 trials and 669 had previously received perampanel 2-12 mg/day; 313 had FIAS with FBTC seizures at core study baseline. Read More

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http://dx.doi.org/10.1111/epi.14645DOI Listing
March 2019
1 Read

Epilepsy in Asia.

Epilepsia 2019 Mar;60 Suppl 1:5-6

Department of Neurology, Inje University School of Medicine, Haeundae Paik Hospital, Busan, South Korea.

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http://dx.doi.org/10.1111/epi.14507DOI Listing
March 2019
2 Reads

Efficacy, safety, and tolerability of perampanel in Asian and non-Asian patients with epilepsy.

Epilepsia 2019 Mar;60 Suppl 1:37-46

Eisai Singapore Pte. Ltd., Singapore.

People of different ethnic or racial backgrounds may experience variations in pharmacokinetic and pharmacodynamic responses to drug therapies. Our post hoc analysis evaluated the efficacy, safety, and tolerability of perampanel in Asian and non-Asian populations with refractory focal seizures with or without focal to bilateral tonic-clonic (FBTC) seizures. This analysis pooled data from 4 randomized, placebo-controlled, phase-3 studies involving patients aged ≥12 years who have focal seizures with or without FBTC seizures. Read More

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http://doi.wiley.com/10.1111/epi.14642
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http://dx.doi.org/10.1111/epi.14642DOI Listing
March 2019
3 Reads

Cerebellar, limbic, and midbrain volume alterations in sudden unexpected death in epilepsy.

Epilepsia 2019 Apr 14;60(4):718-729. Epub 2019 Mar 14.

Department of Clinical and Experimental Epilepsy, University College London Institute of Neurology, London, UK.

Objective: The processes underlying sudden unexpected death in epilepsy (SUDEP) remain elusive, but centrally mediated cardiovascular or respiratory collapse is suspected. Volume changes in brain areas mediating recovery from extreme cardiorespiratory challenges may indicate failure mechanisms and allow prospective identification of SUDEP risk.

Methods: We retrospectively imaged SUDEP cases (n = 25), patients comparable for age, sex, epilepsy syndrome, localization, and disease duration who were high-risk (n = 25) or low-risk (n = 23), and age- and sex-matched healthy controls (n = 25) with identical high-resolution T1-weighted scans. Read More

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http://dx.doi.org/10.1111/epi.14689DOI Listing
April 2019
5 Reads
4.571 Impact Factor

Clinical features of sleep-related hypermotor epilepsy in relation to the seizure-onset zone: A review of 135 surgically treated cases.

Epilepsia 2019 Apr 13;60(4):707-717. Epub 2019 Mar 13.

Department of Neurosciences, Center for Epilepsy Surgery "C. Munari,", Hospital Niguarda, Milan, Italy.

Objectives: Sleep-related hypermotor epilepsy (SHE), formerly nocturnal frontal lobe epilepsy, is characterized by abrupt and typically sleep-related seizures with motor patterns of variable complexity and duration. They seizures arise more frequently in the frontal lobe than in the extrafrontal regions but identifying the seizure onset-zone (SOZ) may be challenging. In this study, we aimed to describe the clinical features of both frontal and extrafrontal SHE, focusing on ictal semiologic patterns in order to increase diagnostic accuracy. Read More

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http://doi.wiley.com/10.1111/epi.14690
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http://dx.doi.org/10.1111/epi.14690DOI Listing
April 2019
10 Reads

A universal automated tool for reliable detection of seizures in rodent models of acquired and genetic epilepsy.

Epilepsia 2019 Apr 13;60(4):783-791. Epub 2019 Mar 13.

Departments of Neuroscience and Medicine, Central Clinical School, Monash University, Melbourne, Victoria, Australia.

Objective: Prolonged electroencephalographic (EEG) monitoring in chronic epilepsy rodent models has become an important tool in preclinical drug development of new therapies, in particular those for antiepileptogenesis, disease modification, and treating drug-resistant epilepsy. We have developed an easy-to-use, reliable, computational tool for automated detection of electrographic seizures from prolonged EEG recordings in rodent models of epilepsy.

Methods: We applied a novel method based on advanced time-frequency analysis that detects EEG episodes with excessive activity in certain frequency bands. Read More

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http://dx.doi.org/10.1111/epi.14691DOI Listing
April 2019
1 Read

Antioxidant treatment after epileptogenesis onset prevents comorbidities in rats sensitized by a past stressful event.

Epilepsia 2019 Apr 13;60(4):648-655. Epub 2019 Mar 13.

INSERM, INS, Inst Neurosci Syst, Aix Marseille University, Marseille, France.

Objective: Unresolved past stressful events can induce a state of vulnerability to epilepsy and comorbidities. Using an experimental model of stress-induced vulnerability to depression, we tested whether an antioxidant treatment applied after the onset of epileptogenesis was disease modifying and could prevent the occurrence of comorbidities.

Methods: We used social defeat (SD) to trigger a state of vulnerability in half of the SD-exposed population of rats. Read More

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http://dx.doi.org/10.1111/epi.14692DOI Listing
April 2019
1 Read

Diagnostic implications of genetic copy number variation in epilepsy plus.

Epilepsia 2019 Apr 13;60(4):689-706. Epub 2019 Mar 13.

Pediatric Neurology, Neurogenetics and Neurobiology Unit and Laboratories, Neuroscience Department, A Meyer Children's Hospital, University of Florence, Florence, Italy.

Objective: Copy number variations (CNVs) represent a significant genetic risk for several neurodevelopmental disorders including epilepsy. As knowledge increases, reanalysis of existing data is essential. Reliable estimates of the contribution of CNVs to epilepsies from sizeable populations are not available. Read More

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http://dx.doi.org/10.1111/epi.14683DOI Listing
April 2019
10 Reads

Validated outcome of treatment changes according to International League Against Epilepsy criteria in adults with drug-resistant focal epilepsy.

Epilepsia 2019 Mar 13. Epub 2019 Mar 13.

Clinical Pharmacology Unit, Department of Internal Medicine and Therapeutics, University of Pavia and Clinical Trial Center, IRCCS Mondino Foundation, Pavia, Italy.

Objective: Although many studies have attempted to describe treatment outcomes in patients with drug-resistant epilepsy, results are often limited by the adoption of nonhomogeneous criteria and different definitions of seizure freedom. We sought to evaluate treatment outcomes with a newly administered antiepileptic drug (AED) in a large population of adults with drug-resistant focal epilepsy according to the International League Against Epilepsy (ILAE) outcome criteria.

Methods: This is a multicenter, observational, prospective study of 1053 patients with focal epilepsy diagnosed as drug-resistant by the investigators. Read More

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http://dx.doi.org/10.1111/epi.14685DOI Listing
March 2019
2 Reads

The spectrum of neuroimaging findings in febrile infection-related epilepsy syndrome (FIRES): A literature review.

Epilepsia 2019 Apr 10;60(4):585-592. Epub 2019 Mar 10.

Department of Radiology, Great Ormond Street Hospital for Children, London, UK.

Febrile infection-related epilepsy syndrome (FIRES) is a rare severe epileptic syndrome occurring in previously healthy children and characterized by refractory status epilepticus (SE) following a febrile illness. Brain imaging findings in affected patients have been reported in few case series and some case reports. This article is a comprehensive review of the magnetic resonance imaging (MRI) characteristics in all reported patients with a diagnosis of FIRES, describing the findings in the acute and chronic phases of the disease, and discussing possible pathogenesis and radiologic differential diagnoses. Read More

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http://dx.doi.org/10.1111/epi.14684DOI Listing
April 2019
1 Read

Anxiety and depression symptoms disrupt resting state connectivity in patients with genetic generalized epilepsies.

Epilepsia 2019 Apr 10;60(4):679-688. Epub 2019 Mar 10.

Laboratory of Neuroimaging, University of Campinas, Campinas, Brazil.

Objective: To analyze the lifetime trajectories in genetic generalized epilepsies (GGEs) and investigate the impact of symptoms of anxiety and depression on resting state functional connectivity (FC).

Methods: Seventy-four GGE patients were classified according to the pharmacological response as seizure-free (12 patients), pharmacoresistant (PhR; 14 patients), and fluctuating (FL; 48 patients). Fifty-four subjects completed both the Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI), and 38 also underwent 3-T resting state functional magnetic resonance imaging. Read More

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http://doi.wiley.com/10.1111/epi.14687
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http://dx.doi.org/10.1111/epi.14687DOI Listing
April 2019
4 Reads

Psychological long-term outcome in patients with psychogenic nonepileptic seizures.

Epilepsia 2019 Apr 5;60(4):669-678. Epub 2019 Mar 5.

Department of Neurology, Epilepsy Center, University Hospital Erlangen, Erlangen, Germany.

Objective: To examine the long-term outcome of psychological status, personality, and health-related quality of life (HRQoL) in patients with psychogenic nonepileptic seizures (PNES) and to define predictors of favorable outcome of cessation of PNES.

Method: Patients diagnosed with PNES during video-electroencephalography (EEG) monitoring at the Erlangen Epilepsy Center were contacted 1-16 years after communicating the diagnosis. Follow-up information from each participant was obtained by interview (PNES outcome) and by self-reported questionnaires of psychological symptoms (Beck Depression Inventory-II, Symptom Checklist-90-Standard, Dissociative Symptoms questionnaire), personality traits (Freiburg Personality Inventory-Revised), and HRQoL (36-Item Short Form Health Survey). Read More

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http://dx.doi.org/10.1111/epi.14682DOI Listing

Erratum.

Authors:

Epilepsia 2019 Mar 1;60(3):584. Epub 2019 Feb 1.

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http://dx.doi.org/10.1111/epi.14672DOI Listing

Schizophrenia is a later-onset feature of PCDH19 Girls Clustering Epilepsy.

Epilepsia 2019 Mar 3;60(3):429-440. Epub 2019 Mar 3.

Division of Neurology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.

Objective: To investigate the occurrence of psychosis and serious behavioral problems in females with protocadherin 19 gene (PCDH19) pathogenic variants.

Methods: We evaluated whether psychosis and serious behavioral problems had occurred in 60 females (age 2-75 years) with PCDH19 pathogenic variants belonging to 35 families. Patients were identified from epilepsy genetics databases in Australia, New Zealand, the United States, and Canada. Read More

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http://doi.wiley.com/10.1111/epi.14678
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http://dx.doi.org/10.1111/epi.14678DOI Listing
March 2019
8 Reads

Effect of carbamazepine on spontaneous recurrent seizures recorded from the dentate gyrus in rats with kainate-induced epilepsy.

Epilepsia 2019 Apr 27;60(4):636-647. Epub 2019 Feb 27.

Departments of Physiology and Neurosurgery, University of Utah School of Medicine, Salt Lake City, Utah.

Objective: Animal models of chronic epilepsy with spontaneous recurrent seizures (SRSs) may be useful in the discovery and mechanistic analyses of antiseizure drugs (ASDs). Carbamazepine (CBZ), a widely used ASD with a well-defined mechanism, was analyzed in this proof-of-principle study to determine how a traditional ASD affects the properties of SRSs.

Methods: The effects of CBZ on electrographic SRSs recorded from the dentate gyrus were studied in freely behaving rats using a repeated, low-dose kainate model of acquired epilepsy with a repeated-measures, crossover protocol. Read More

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http://dx.doi.org/10.1111/epi.14680DOI Listing
April 2019
1 Read

Transient use of a systemic adenosine kinase inhibitor attenuates epilepsy development in mice.

Epilepsia 2019 Apr 27;60(4):615-625. Epub 2019 Feb 27.

RS Dow Neurobiology Laboratories, Portland, Oregon.

Objective: Over one-third of all patients with epilepsy are refractory to treatment and there is an urgent need to develop new drugs that can prevent the development and progression of epilepsy. Epileptogenesis is characterized by distinct histopathologic and biochemical changes, which include astrogliosis and increased expression of the adenosine-metabolizing enzyme adenosine kinase (ADK; EC 2.7. Read More

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http://doi.wiley.com/10.1111/epi.14674
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http://dx.doi.org/10.1111/epi.14674DOI Listing
April 2019
8 Reads

Effects of an epilepsy-specific Internet intervention (Emyna) on depression: Results of the ENCODE randomized controlled trial.

Epilepsia 2019 Apr 25;60(4):656-668. Epub 2019 Feb 25.

Department of Clinical Psychology, Helmut Schmidt University, Hamburg, Germany.

Objective: Depression and anxiety are highly prevalent among people with epilepsy (PwE) but often remain unrecognized and treated inadequately. Effective psychosocial treatments such as cognitive behavioral therapy (CBT) are rarely available to most PwE, which is one reason electronically delivered CBT (eCBT) is regarded as promising. This study examined an eCBT intervention, termed Emyna, that was tailored to suit the needs of PwE. Read More

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http://dx.doi.org/10.1111/epi.14673DOI Listing
April 2019
12 Reads
4.571 Impact Factor

Efficacy and tolerability of the ketogenic diet versus high-dose adrenocorticotropic hormone for infantile spasms: A single-center parallel-cohort randomized controlled trial.

Epilepsia 2019 Mar 23;60(3):441-451. Epub 2019 Feb 23.

Department of Pediatrics and Adolescent Health, Medical University of Vienna, Vienna, Austria.

Objective: To compare the efficacy and safety of the ketogenic diet (KD) with standard adrenocorticotropic hormone (ACTH) treatment in infants with West syndrome.

Methods: In this parallel-cohort (PC) randomized controlled trial (RCT), infants were randomly allocated to KD or high-dose ACTH. Those who could not be randomized were followed in a PC. Read More

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http://dx.doi.org/10.1111/epi.14679DOI Listing
March 2019
1 Read

Response to antiseizure medications in neonates with acute symptomatic seizures.

Epilepsia 2019 Mar 20;60(3):e20-e24. Epub 2019 Feb 20.

Department of Pediatrics, University of Michigan, Ann Arbor, Michigan.

In a prospective cohort of 534 neonates with acute symptomatic seizures, 66% had incomplete response to the initial loading dose of antiseizure medication (ASM). Treatment response did not differ by gestational age, sex, medication, or dose. The risk of incomplete response was highest for seizures due to intracranial hemorrhage and lowest for hypoxic-ischemic encephalopathy, although the difference was not significant after adjusting for high seizure burden and therapeutic hypothermia treatment. Read More

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http://dx.doi.org/10.1111/epi.14671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443409PMC
March 2019
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A rational, multispectral mapping algorithm for primary motor cortex: A primary step before cortical stimulation.

Epilepsia 2019 Mar 20;60(3):547-559. Epub 2019 Feb 20.

Department of Epilepsy, Movement Disorders, and Physiology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Objective: For future artificial intelligence-based brain mapping, development of a rational and safe scoring system for a brain motor mapping algorithm using electrocorticography (ECoG score), which contains various spectral, purely intrinsic brain activities, is necessary for either before or in the absence of electrical cortical stimulation (ECS).

Methods: We evaluated 1114 electrodes of 10 consecutive focal epilepsy patients who underwent subdural electrode implantation before epilepsy surgery at Kyoto University Hospital during 2011-2017. Data from ECoG-based mapping (bandpass filter of 0. Read More

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http://doi.wiley.com/10.1111/epi.14669
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http://dx.doi.org/10.1111/epi.14669DOI Listing
March 2019
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Starting ketamine for neuroprotection earlier than its current use as an anesthetic/antiepileptic drug late in refractory status epilepticus.

Epilepsia 2019 Mar 19;60(3):373-380. Epub 2019 Feb 19.

Neurology Department, VA Greater Los Angeles Healthcare System, Sepulveda Ambulatory Care Center and Nursing Home, North Hills, California.

Ketamine is currently being used as an anesthetic/antiepileptic drug in refractory status epilepticus. To validate its use, 2 clinical trials are recruiting patients. However, preclinical studies of its use in chemically induced status epilepticus in rodents have shown that it is remarkably neuroprotective, through N-methyl-d-aspartate-receptor blockade, even when given after the onset of status epilepticus. Read More

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http://dx.doi.org/10.1111/epi.14676DOI Listing

Indoleamine 2,3-dioxygenase 1 deletion promotes Theiler's virus-induced seizures in C57BL/6J mice.

Epilepsia 2019 Apr 15;60(4):626-635. Epub 2019 Feb 15.

Department of Animal Sciences, College of Agricultural, Consumer, and Environmental Sciences, Urbana, Illinois.

Objective: Viral encephalitis increases the risk for developing seizures and epilepsy. Indoleamine 2,3-dioxygenase 1 (Ido1) is induced by inflammatory cytokines and functions to metabolize tryptophan to kynurenine. Kynurenine can be further metabolized to produce kynurenic acid and the N-methyl-d-aspartate receptor agonist quinolinic acid (QuinA). Read More

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http://dx.doi.org/10.1111/epi.14675DOI Listing
April 2019
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The effect of medial pulvinar stimulation on temporal lobe seizures.

Epilepsia 2019 Apr 14;60(4):e25-e30. Epub 2019 Feb 14.

Clinical Neurophysiology and Epileptology Department, Timone Hospital, Assitance Publique Hôpitaux de Marseille, Marseille, France.

We investigated the effect of electrical stimulation of the medial pulvinar (PuM) in terms of its effect on temporal lobe seizures. Eight patients with drug-resistant temporal lobe epilepsy undergoing stereoelectroencephalographic exploration were included. All had at least one electrode exploring the PuM. Read More

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http://dx.doi.org/10.1111/epi.14677DOI Listing
April 2019
1 Read

Ventilatory response to CO in patients with epilepsy.

Epilepsia 2019 Mar 12;60(3):508-517. Epub 2019 Feb 12.

Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, Iowa.

Objective: Severe periictal respiratory depression is thought to be linked to risk of sudden unexpected death in epilepsy (SUDEP) but its determinants are largely unknown. Interindividual differences in the interictal ventilatory response to CO (hypercapnic ventilatory response [HCVR] or central respiratory CO chemosensitivity) may identify patients who are at increased risk for severe periictal hypoventilation. HCVR has not been studied previously in patients with epilepsy; therefore we evaluated a method to measure it at bedside in an epilepsy monitoring unit (EMU) and examined its relationship to postictal hypercapnia following generalized convulsive seizures (GCSs). Read More

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http://dx.doi.org/10.1111/epi.14660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401234PMC
March 2019
3 Reads

Curcumin reduces development of seizurelike events in the hippocampal-entorhinal cortex slice culture model for epileptogenesis.

Epilepsia 2019 Apr 12;60(4):605-614. Epub 2019 Feb 12.

Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands.

Objective: Inhibition of the mammalian target of rapamycin (mTOR) pathway could be antiepileptogenic in temporal lobe epilepsy (TLE), possibly via anti-inflammatory actions. We studied effects of the mTOR inhibitor rapamycin and the anti-inflammatory compound curcumin-also reported to inhibit the mTOR pathway-on epileptogenesis and inflammation in an in vitro organotypic hippocampal-entorhinal cortex slice culture model.

Methods: Brain slices containing hippocampus and entorhinal cortex were obtained from 6-day-old rat pups and maintained in culture for up to 3 weeks. Read More

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http://dx.doi.org/10.1111/epi.14667DOI Listing
April 2019
1 Read