24,510 results match your criteria Epididymal Tuberculosis


Research Update and Opportunity of Non-hormonal Male Contraception: Histone Demethylase KDM5B-Based Targeting.

Pharmacol Res 2018 Dec 11. Epub 2018 Dec 11.

Department of Animal Science & Technology and BET Research Institute, Chung-Ang University, Anseong, Gyeonggi-do, 17546, Republic of Korea. Electronic address:

With the continued increase in global human population, diverse contraception approaches have become increasingly essential, including non-hormonal male contraception. Non-hormonal approaches to contraception are very convenient; however, such options are limited because data regarding the identification and characterization of tissue/cell-specific targets and appropriate small molecule candidate contraceptives are lacking. Based on in-silico studies of genomics, transcriptomics, and proteomics, performed by mining datasets in PubMed, we first reviewed testis-, epididymis-, and germline cell-specific genes/proteins, with the aim of presenting evidence that many of these could become 'druggable' targets for the development of non-hormonal male contraceptives in the future. Read More

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December 2018

The serine protease testisin is present on the surface of capacitated stallion spermatozoa and interacts with key zona pellucida binding proteins.

Andrology 2018 Dec 13. Epub 2018 Dec 13.

Priority Research Centre for Reproductive Science, University of Newcastle, Callaghan, NSW, Australia.

Background And Objectives: Serine proteases are emerging as important players in the spermatozoon's acquisition of functional competence. This study aimed to characterize the serine protease testisin (PRSS21) in stallion spermatozoa, examining its surface expression, possible origins in the testis and epididymis, and changes in response to capacitation and acrosome reaction, as well as its capacity to form high molecular weight complexes and interact with other proteins.

Materials And Methods: The role of serine proteases in spontaneous capacitation and acrosome reaction of stallion spermatozoa was established using the serine protease inhibitor, AEBSF. Read More

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December 2018

Experimental exposure to gasohol impairs sperm quality with recognition of the classification pattern of exposure groups by machine learning algorithms.

Environ Sci Pollut Res Int 2018 Dec 13. Epub 2018 Dec 13.

Graduate Program in Environment and Regional Development, University of Western São Paulo - UNOESTE, Presidente Prudente, SP, 19067-175, Brazil.

Contamination caused by leakage at gas stations leads to possible exposure of the general population when in contact with contaminated water and soil. The present study aimed to evaluate the reproductive effects of exposure of adult male rats to gasohol and evaluate the performance of machine learning (ML) algorithms for pattern recognition and classification of the exposure groups. Rats were orally exposed to 0 (control), 16 (EA), 160 (EB), or 800 mg kg bw day of gasohol (EC), for 30 consecutive days. Read More

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December 2018

Evaluation of serologic testing of rams in the management of Brucella ovis in a domestic sheep flock.

J Vet Diagn Invest 2018 Dec 12:1040638718814591. Epub 2018 Dec 12.

Department of Veterinary Sciences, Wyoming State Veterinary Laboratory, University of Wyoming, Laramie, WY.

Brucella ovis is a bacterial pathogen present in most major sheep-producing regions of the world. The pathogen is associated with ram infertility, decreased ewe conception rates, and premature lambs. Twenty ELISA seropositive or indeterminate rams were culled from a B. Read More

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December 2018

[The effect of inadequate Vitamin D on sperm quality].

Zhonghua Yi Xue Za Zhi 2018 Dec;98(46):3746-3750

Center for Reproduction and Genetics, the Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215002, China.

To analyze the effect of insufficient intake of vitamin D (VD) on sperm quality and male fertility and to discuss the mechanism of the effect. VD deficiency mice were fed with VD-deficient diet and light-sheltered. The sperm motility, morphology, ultrastructure, testicular pathology, sex hormones and fertility of normal and VD-deficient mice were analyzed to investigate the effects of VD deficiency on male reproduction. Read More

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December 2018

[Retrospective analysis of factors affecting patency rates and causes of failure in use of single-armed two-suture microsurgical vasoepididymostomy].

Zhonghua Yi Xue Za Zhi 2018 Dec;98(46):3741-3745

Department of Andrology, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China.

To analyze the factors affecting the patency rate of microsurgical single-stitch longitudinal intussusception vasoepididymostomy and to explore the possible causes of failure. The clinical data of 87 patients with epididymal obstructive azoospermia who underwent microsurgical vasoepididymostomy from January 2015 to February 2018 in the First Affiliated Hospital of Fujian Medical University were analyzed retrospectively. We observed the patency rate postoperatively and evaluated several factors that possibly related to the patency rates. Read More

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December 2018

Ameliorating effect of encapsulated hepatocyte-like cells derived from umbilical cord in high mannuronic alginate scaffolds on acute liver failure in rats.

Iran J Basic Med Sci 2018 Sep;21(9):928-935

Transplantation Ward, Ahvaz Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Objectives: In this study, effects of encapsulated umbilical cord stem cells (UCSCs)-derived hepatocyte-like cells (HLCs) in high mannuronic alginate scaffolds was investigated on CCl-induced acute liver failure (ALF) in rats.

Material And Methods: UCSCs were encapsulated in high mannuronic alginate scaffolds. Then the UCSCs differentiated into HLCs for treatment of CCl-induced ALF in rats. Read More

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September 2018

EGCG Reduces Obesity and White Adipose Tissue Gain Partly Through AMPK Activation in Mice.

Front Pharmacol 2018 22;9:1366. Epub 2018 Nov 22.

Key Laboratory of Puer Tea Science, Ministry of Education, Yunnan Agricultural University, Kunming, China.

(-)-Epigallocatechin-3-gallate (EGCG), which is the most abundant catechin in green tea, has many potential health benefits, including decreased weight gain and/or adipose tissue weight. Suggested mechanisms for body weight reduction by EGCG include: (1) a decrease in calorie intake and (2) activation of AMPK in liver, skeletal muscle, and white adipose tissue. However, only one study supports the AMPK hypothesis. Read More

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November 2018

Giving Birth After Fertility Sparing Treatment of Embrional Carcinoma Figo III C: Case Report and Literature Review.

Med Arch 2018 Nov;72(5):371-373

Department for Pathology, Policlinic for Laboratory Diagnostic, University Clinical Center Tuzla, Tuzla, Bosnia and Herzegovina.

Introduction: Malignant ovarian germ cell tumors (MOGCTs) account for 2-5% of all ovarian cancers and among them pure embryonal cell cancer is rare condition (1, 2, 3, 4).

Aim: To show successful pregnancy after unilateral salpingooopherectomy and chemotherapy in a girl with embryonal carcinoma of ovary (ECO).

Case Report: Patient had FIGO stage III c disease. Read More

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November 2018

Cordycepin reduces weight through regulating gut microbiota in high-fat diet-induced obese rats.

Lipids Health Dis 2018 Dec 6;17(1):276. Epub 2018 Dec 6.

Key Laboratory for Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine Jilin University, Changchun, 130062, China.

Background: An increasing number of studies have shown that obesity is the key etiological agent of cardiovascular diseases, nonalcoholic fatty liver disease, type 2 diabetes and several kinds of cancer and that gut microbiota change was one of the reasons suffering from obesity. At present, the gut microbiota has gained increased attention as a potential energy metabolism organ. Our recent study reported that cordycepin, a major bioactive component separated from Cordyceps militaris, prevented body weight gain in mice fed a high-fat diet directly acting to adipocytes, however, the effect of cordycepin regulating gut microbiota keeps unknown. Read More

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December 2018

Adipose tissue is less responsive to food restriction anti-inflammatory effects than liver, muscle, and brain in mice.

Braz J Med Biol Res 2018 Dec 10;52(1):e8150. Epub 2018 Dec 10.

Departamento de Farmacologia e Terapêutica, Universidade Estadual de Maringá, Maringá, PR, Brasil.

High caloric intake promotes chronic inflammation, insulin resistance, and chronic diseases such as type-2 diabetes, which may be prevented by food restriction (FR). The effect of FR on expression of pro-inflammatory and anti-inflammatory genes in adipose tissue, liver, muscle, and brain was compared. Male Swiss mice were submitted to FR (FR group) or had free access to food (control group) during 56 days. Read More

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December 2018

Paratesticular rhabdomyosarcoma mimicking complicated epididymal cyst.

J Cancer Res Ther 2018 Dec;14(Supplement):S1241-S1243

Department of Urology, Faculty of Medicine, Kemerburgaz University, Medical Park Bursa Hospital, Bursa, Turkey.

Paratesticular rhabdomyosarcoma (RMS) is a rare nongerm cell intrascrotal malignant tumor in children and young adult/teens resulting from the mesenchymal tissues of the tunica vaginalis, epididymis, spermatic cord, and testis. RMS accounts for approximately 7% of all genitourinary tract RMSs and 12% of all pediatric scrotal neoplasms. Patients usually present with a painless unilateral scrotal mass. Read More

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December 2018

Seasonal expressions of androgen receptor, P450arom and estrogen receptors in the epididymis of the wild ground squirrel (Citellus dauricus Brandt).

Gen Comp Endocrinol 2019 Jan 25;270:131-138. Epub 2018 Oct 25.

College of Biological Sciences and Technology, Beijing Forestry University, Beijing 100083, PR China. Electronic address:

The aim of this study was to investigate the seasonal expressions of androgen receptor (AR), estrogen receptors alpha and beta (ERα and ERβ) and aromatase cytochrome P450 (P450arom) in the epididymis of the wild ground squirrel. Histologically, the epididymis was with larger duct diameter and cell population during the breeding season. AR was presented in the peritubular smooth muscle cells and epithelial cells in the whole epididymis with stronger staining in the breeding period. Read More

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January 2019
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Dual targeting of Nur77 and AMPKα by isoalantolactone inhibits adipogenesis in vitro and decreases body fat mass in vivo.

Int J Obes (Lond) 2018 Dec 11. Epub 2018 Dec 11.

Department of Food Science and Technology, Keimyung University, Daegu, 42601, Republic of Korea.

Background: Suppression of adipogenesis has been considered as a potential target for the prevention and treatment of obesity and associated metabolic disorders, and the nuclear receptor 4A1 (NR4A1/Nur77) and AMPKα are known to play important roles during early and intermediate stages of adipogenesis. Therefore, we hypothesized that dual targeting Nur77 and AMPKα would show strong inhibitory effect on adipogenesis.

Methods: We screened a herbal medicine-based small molecule library to identify novel natural compounds dual targeting Nur77 and AMPKα, and the antiadipogenic effects and mechanisms of action of a "hit" compound were studied in 3T3-L1 cells. Read More

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December 2018

IRX5 regulates adipocyte amyloid precursor protein and mitochondrial respiration in obesity.

Int J Obes (Lond) 2018 Dec 11. Epub 2018 Dec 11.

KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, 5020, Bergen, Norway.

Objective: A causal obesity risk variant in the FTO locus was recently shown to inhibit adipocyte thermogenesis via increased adipose expression of the homeobox transcription factors IRX3 and IRX5. However, causal effects of IRX5 on fat storage remain to be shown in vivo, and discovery of downstream mediators may open new therapeutic avenues.

Methods: 17 WT and 13 Irx5 knockout (KO) mice were fed low-fat control (Ctr) or high-fat (HF) diet for 10 weeks. Read More

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December 2018
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Metabolomic Analysis of Diet-Induced Obese Mice Supplemented with Eicosapentaenoic Acid.

Exp Clin Endocrinol Diabetes 2018 Dec 10. Epub 2018 Dec 10.

Department of Metabolic Medicine, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka, Japan.

Eicosapentaenoic acid (EPA) is an omega-3 fatty acid with anti-inflammatory effects. To determine the effects of EPA on metabolic pathways in obese adipose tissues and liver, mice were fed normal chow diet (NCD), high-fat diet (HFD), or 3% EPA-containing high fat diet (HFD+EPA) for 8 weeks. Metabolomic analysis was performed using epididymal adipose tissues (epi WAT) and liver. Read More

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December 2018
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Liraglutide induces beige fat development and promotes mitochondrial function in diet induced obesity mice partially through AMPK-SIRT-1-PGC1-α cell signaling pathway.

Endocrine 2018 Dec 9. Epub 2018 Dec 9.

Department of Physician Assistant, College of Health Professions, Central Michigan University MI, Mount Pleasant, MI, 48859, USA.

Purpose: Glucagon like peptide-1 (GLP-1) is produced to induce postprandial insulin secretion. Liraglutide, a full agonist of the GLP-1 receptor, has a protective effect on weight gain in obese subjects. Brown adipose tissue plays a major role in the control of energy balance and is known to be involved in the weight loss regulated by liraglutide. Read More

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December 2018

A Rare Scrotal Tumor: Epididymal Cavernous Hemangioma.

Case Rep Urol 2018 6;2018:4259563. Epub 2018 Nov 6.

Urology Department, La Rabta Hospital, Tunis, Tunisia.

Introduction: Paratesticular tumors are rarely observed among scrotal neoplasm. Various types of benign lesions are described. Cavernous hemangioma belongs to uncommon epididymal benign tumors. Read More

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November 2018
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The depot-specific and essential roles of CBP/p300 in regulating adipose plasticity.

J Endocrinol 2019 Feb;240(2):257-269

Naomi Berrie Diabetes Center, Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.

Fat remodeling has been extensively explored through protein deacetylation, but not yet acetylation, as a viable therapeutic approach in the management of obesity and related metabolic disorders. Here, we investigated the functions of key acetyltransferases CBP/p300 in adipose remodeling and their physiological effects by generating adipose-specific deletion of CBP (Cbp-AKO), p300 (p300-AKO) and double-knockout (Cbp/p300-AKO) models. We demonstrated that Cbp-AKO exhibited marked brown remodeling of inguinal WAT (iWAT) but not epididymal WAT (eWAT) after cold exposure and that this pattern was exaggerated in diet-induced obesity (DIO). Read More

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February 2019

Pravastatin attenuates testicular damage induced by doxorubicin - a stereological and histopatological study.

J Basic Clin Physiol Pharmacol 2018 Dec 11. Epub 2018 Dec 11.

Cellular and Molecular Research Center, Department of Anatomical Sciences, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background The aim of this study is to investigate the effects of pravastatin (PS) against doxorubicin (DOX)-induced testicular toxicity. Methods A total of 24 healthy male Sprague-Dawley rats were equally divided into four groups. Group I received normal saline, Group II received PS (20 mg/kg b. Read More

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December 2018

The contribution and perspectives of proteomics to uncover ovarian cancer tumor markers.

Transl Res 2018 Nov 20. Epub 2018 Nov 20.

Department of Biochemistry and Immunology, FMRP, University of São Paulo, Ribeirão Preto, SP, Brazil; Center for Cell Based Therapy, Hemotherapy Center of Ribeirão Preto, Ribeirão Preto, SP, Brazil. Electronic address:

Despite all the advances in understanding the mechanisms involved in ovarian cancer (OC) development, many aspects still need to be unraveled and understood. Tumor markers (TMs) are of special interest in this disease. Some aspects of clinical management of OC might be improved by the use of validated TMs, such as differentiating subtypes, defining the most appropriate treatment, monitoring the course of the disease, or predicting clinical outcome. Read More

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November 2018

Ethylene dimethane sulfonate (EDS) ablation of Leydig cells in adult rat depletes testosterone resulting in epididymal sperm granuloma: Testosterone replacement prevents granuloma formation.

Reprod Biol 2018 Dec 5. Epub 2018 Dec 5.

Department of Biology, Texas Woman's University, Denton, Texas, USA. Electronic address:

Sperm granuloma may develop in the epididymis following vasectomy or chemical insults. Inflammation due to sperm granuloma causes abdominal and scrotal pain. Prolonged and persistent inflammation in the epididymis due to sperm granuloma may lead to infertility. Read More

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December 2018

Update on the cellular and molecular aspects of cystic fibrosis transmembrane conductance regulator (CFTR) and male fertility.

Morphologie 2018 Dec 4. Epub 2018 Dec 4.

Département de gynécologie obstétrique et reproduction humaine - CECOS, CHU de Rennes, 16, boulevard de Bulgarie, 35000 Rennes, France; Inserm, université Rennes, EHESP, Irset (Instiut de recherche en santé,environnement et travail)-UMR_S1085, 35000 Rennes, France; Université de Rennes 1, 2, avenue du Pr Léon-Bernard, 35000 Rennes, France. Electronic address:

CFTR protein regulates electrolyte and fluid transport in almost all tissues with exocrine function, including male reproductive tract. Mutation of CFTR gene causes cystic fibrosis (CF), which affects the function of several organs, and impairs male fertility. The role of CFTR protein in different compartments of male reproductive tract (testis, epididymis, sperm) as well as an impact of CFTR mutation(s) on male fertility phenotype is discussed in relation with the choice of optimal technique for Assisted Reproductive Techniques (ART) management. Read More

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December 2018

TopBP1 deficiency impairs the localization of proteins involved in early recombination and results in meiotic chromosome defects during spermatogenesis.

Biochem Biophys Res Commun 2018 Dec 6. Epub 2018 Dec 6.

Carcinogenesis and Metastasis Research Branch, National Cancer Center, Gyeonggi, Republic of Korea; Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Gyeonggi, Republic of Korea. Electronic address:

Topoisomerase IIβ-binding protein 1 (TopBP1) is BRCT domain-containing protein that is required for DNA double-strand break (DSB) repair and DNA damage responses; however, its function during the early stage of spermatogenesis is still unclear. To investigate the physiological role of TopBP1, we have generated germ cell-specific TopBP1-depleted mouse model. TopBP1-deleted mice were infertile, showed a loss of germ cells and had meiotic defects. Read More

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December 2018

Idiopathic Pulmonary Fibrosis: Prospective, Case-Controlled Study of Natural History and Circulating Biomarkers.

Chest 2018 Dec;154(6):1359-1370

Immunology and Inflammation Therapeutic Area, Sanofi R&D, Paris, France.

Background: Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease with 3 to 5 years' survival. Although FVC is used to assess disease progression and treatment response, identifying predictive circulating blood biomarkers could help identify specific biologic pathways for treatment. An international, prospective, noninterventional, case-controlled, 52-week study was therefore conducted to identify a clinical and biomarker baseline profile predictive of longitudinal disease behavior. Read More

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December 2018

Lipophagy contributes to long-term storage of spermatozoa in the epididymis of the Chinese soft-shelled turtle Pelodiscus sinensis.

Reprod Fertil Dev 2018 Dec 10. Epub 2018 Dec 10.

Spermatozoa are known to be stored in the epididymis of the Chinese soft-shelled turtle Pelodiscus sinensis for long periods after spermiation from the testes, but the molecular mechanisms underlying this storage are largely unknown. In this study, epididymal spermatozoa were investigated to determine the potential molecular mechanism for long-term sperm storage in P. sinensis. Read More

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December 2018
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Lack of NWC protein (c11orf74 homolog) in murine spermatogenesis results in reduced sperm competitiveness and impaired ability to fertilize egg cells in vitro.

PLoS One 2018 6;13(12):e0208649. Epub 2018 Dec 6.

Laboratory of Molecular and Cellular Immunology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland.

NWC is an uncharacterised protein containing three strongly conserved domains not found in any other known protein. Previously, we reported that the NWC protein is detected in cells in the germinal layer in murine testes (strain: C57BL/6), and its knockout results in no obvious phenotype. We determined the NWC expression pattern during spermatogenesis, and found this protein in spermatocytes and round spermatids, but not in epididymal sperm. Read More

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December 2018
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Phyllanthus emblica leaf extract ameliorates testicular damage in rats with chronic stress.

J Zhejiang Univ Sci B 2018 Dec.;19(12):948-959

Department of Anatomy, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.

Stress affects the male reproductive system and can cause sub-fertility or infertility. Although Phyllanthus emblica L. (PE) extract has been shown to have high antioxidant capacity and protective properties in damaged tissue, the preventive effects of PE extract on testicular function from stress-related impairment have never been demonstrated. Read More

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December 2018
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Brucella canis infection in a young dog with epididymitis and orchitis.

Schweiz Arch Tierheilkd 2018 Dec;160(12):743-748

Institute of Veterinary Bacteriology, Vetsuisse Faculty, University of Zurich.

Introduction: The following case report describes the clinical and diagnostic procedure for suspected brucellosis infection in a dog. A 21 month old intact male Border Collie was presented with an enlarged right testicle and epididymis. The dog was imported to Switzerland from Germany at the age of three months, but was never abroad since then. Read More

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December 2018
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Down-regulation of steroidogenesis-related genes and its accompanying fertility decline in streptozotocin-induced diabetic male rats: ameliorative effect of metformin.

Andrology 2018 Dec 4. Epub 2018 Dec 4.

Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia.

Background: Metformin has long been used for glycemic control in diabetic state. Recently, other benefits of metformin beyond blood glucose regulation have emerged.

Objectives: To investigate the effect of metformin on the expression of testicular steroidogenesis-related genes, spermatogenesis, and fertility of male diabetic rats. Read More

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December 2018
2 Reads

The antioxidant activity of steamed ginger and its protective effects on obesity induced by high-fat diet in C57BL/6J mice.

Nutr Res Pract 2018 Dec 30;12(6):503-511. Epub 2018 Nov 30.

Department of Food Science and Human Nutrition, Chonbuk National University and Obesity Research Center, 567 Baekje-daero, Dukjin-gu, Jeonju, Jeonbuk 54896, Korea.

Background/objectives: Ginger, a root vegetable, is known to have antioxidant and antiobesity effects. Preparation, such as by steaming, can affect the chemical composition of prepared root vegetables or herbs and can change their functional activities. In the present study, we investigated the protective effects of steamed ginger against oxidative stress and steatosis in C57BL/6J mice fed a high-fat diet. Read More

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December 2018
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Coating rice with mulberry leaves rich in deoxynojirimycin ameliorates hyperglycemia and dyslipidemia in C57BL/KsJ mice.

Nutr Res Pract 2018 Dec 13;12(6):469-478. Epub 2018 Sep 13.

Department of Food and Nutrition, Chosun University, 309 Pilmun-daero, Dong-gu, Gwangju 61452, Korea.

Background/objectives: Mulberry leaf (ML) has been shown to have an inhibitory effect on α-glucosidase, and suppresses postprandial hyperglycemia, which may be related to its deoxynojirimycin (DNJ) content. This study was conducted to investigate the hypoglycemic and dyslipidemic effects of rice coated with ML rich in DNJ in a type 2 diabetes mouse model.

Materials/methods: The mice were divided into four groups (n = 8 each): non-diabetic normal control (NC); diabetic control (DM-C), fed with 10% polished rice powder (DM-R); and fed with 10% polished rice powder coated with DNJ-rich ML (DM-DNJR). Read More

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December 2018
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Making new biomarkers a reality: the case of serum human epididymis protein 4.

Clin Chem Lab Med 2018 Dec 4. Epub 2018 Dec 4.

Department of Biomedical and Clinical Sciences "Luigi Sacco", University of Milan, Milan, Italy.

Background Measurement of human epididymis protein 4 (HE4) in serum has recently been proposed for clinical use in the framework of ovarian cancer (OvCa). We sought to retrace the translational phase and the clinical implementation steps boosting HE4's clinical value and discuss the effects of its introduction on the diagnostic and management pathways. Methods Meta-analyses of running evidence have preliminarily suggested that HE4 may overcome carbohydrate antigen 125 (CA125) in identifying OvCa, showing however several gaps that need to be considered, i. Read More

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December 2018
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Case report of inguinal metastasis of epididymal malignant mesothelioma.

Int Urol Nephrol 2018 Dec 3. Epub 2018 Dec 3.

Department of Urology, The Second Affiliated Hospital of Zhejiang University, NO. 88 Jiefang Road, 310009, Hangzhou, China.

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December 2018
2 Reads

Arsenic aggravated reproductive toxicity in male rats exposed to lead during the perinatal period.

Toxicol Res (Camb) 2018 Nov 9;7(6):1191-1204. Epub 2018 Aug 9.

Department of Zoology , Sri Venkateswara University , Tirupati - 517502 , India . Email: ; ; Tel: +91-9247593000.

The aim of this study was to assess the reproductive toxic effects of arsenic on adult Wistar rats exposed to lead during the perinatal period. The pregnant rats were allowed access to tap water containing 819 mg of lead (Pb) per L or without Pb from conception until weaning. Litter size, survival rate and developmental milestones of the pups delivered by Pb exposed dams were comparable to those of the control rats. Read More

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November 2018
2 Reads

Impaired male fertility and abnormal epididymal epithelium differentiation in mice lacking CRISP1 and CRISP4.

Sci Rep 2018 Dec 3;8(1):17531. Epub 2018 Dec 3.

Instituto de Biología y Medicina Experimental (IByME-CONICET), Buenos Aires, C1428ADN, Argentina.

Epididymal Cysteine Rich Secretory Proteins 1 and 4 (CRISP1 and CRISP4) associate with sperm during maturation and play different roles in fertilization. However, males lacking each of these molecules individually are fertile, suggesting compensatory mechanisms between these homologous proteins. Based on this, in the present work, we generated double CRISP1/CRISP4 knockout (DKO) mice and examined their reproductive phenotype. Read More

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December 2018

Seasonal expressions of luteinising hormone receptor, follicle-stimulating hormone receptor and prolactin receptor in the epididymis of the male wild ground squirrel (Spermophilus dauricus).

Reprod Fertil Dev 2018 Dec 4. Epub 2018 Dec 4.

Luteinising hormone (LH), follicle-stimulating hormone (FSH) and prolactin (PRL) are pituitary-derived hormones and mediate their functions through LH receptor (LHR), FSH receptor (FSHR) and PRL receptor (PRLR) respectively. This study aimed to investigate the seasonal expression patterns of LHR, FSHR and PRLR in the epididymis of the male wild ground squirrel during the breeding and non-breeding seasons. Histologically, principal cells, basal cells, cilia and mature spermatozoa were found in the lumen of caput, corpus and cauda epididymidis in the breeding season, whereas in the non-breeding season, cilia and basal cells were rarely found and the epididymidal duct was devoid of spermatozoa. Read More

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December 2018
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Developmental origins of transgenerational sperm DNA methylation epimutations following ancestral DDT exposure.

Dev Biol 2018 Nov 27. Epub 2018 Nov 27.

Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, WA 99164-4236, USA. Electronic address:

Epigenetic alterations in the germline can be triggered by a number of different environmental factors from diet to toxicants. These environmentally induced germline changes can promote the epigenetic transgenerational inheritance of disease and phenotypic variation. In previous studies, the pesticide DDT was shown to promote the transgenerational inheritance of sperm differential DNA methylation regions (DMRs), also called epimutations, which can in part mediate this epigenetic inheritance. Read More

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November 2018
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Troglitazone activates TRPV1 and causes deacetylation of PPARγ in 3T3-L1 cells.

Biochim Biophys Acta Mol Basis Dis 2018 Nov 26;1865(2):445-453. Epub 2018 Nov 26.

Molecular Signaling Laboratory, School of Pharmacy, University of Wyoming, Laramie, WY 82071, United States of America. Electronic address:

Published research suggests that activation of transient receptor potential vanilloid subfamily 1 (TRPV1) enhances the expression and deacetylation of peroxisome proliferator-activated receptor gamma (PPARγ) to cause browning of white adipose tissue. Here, we show that TRPV1 activation by capsaicin significantly prevents high fat diet-induced obesity in mice. This is associated with an increase in the expression and deacetylation of PPARγ in the epididymal fat of these mice. Read More

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November 2018
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Leptin decreases circulating inflammatory IL-6 and MCP-1 in mice.

Biofactors 2018 Nov 29. Epub 2018 Nov 29.

Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany.

Leptin influences inflammation and immune response. Dose-dependent effects of leptin on biomarkers of inflammation have not been studied in vivo, so far. Leptin-deficient low-density lipoprotein receptor (LDLR) knockout (LDLR ;ob/ob) female mice were treated with three different leptin doses or saline for 12 weeks. Read More

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November 2018
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Insights into a Possible Mechanism Underlying the Connection of Carbendazim-Induced Lipid Metabolism Disorder and Gut Microbiota Dysbiosis in Mice.

Toxicol Sci 2018 Dec;166(2):382-393

Department of Biotechnology, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China.

Carbendazim (CBZ), a systemic, broad-spectrum benzimidazole fungicide, is widely used to control fungal diseases and has been regarded as an endocrine disruptor that causes mammalian toxicity in different target organs. Here, we discovered that chronic administrations of CBZ at 0.2, 1, and 5 mg/kg body weight for 14 weeks not only changed the composition of gut microbiota but also induced significant increases in body, liver, and epididymal fat weight in mice. Read More

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December 2018

Chlorella vulgaris ameliorates testicular toxicity induced by deltamethrin in male rats via modulating oxidative stress.

Andrologia 2018 Nov 29:e13214. Epub 2018 Nov 29.

Department of Pharmacology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.

This study was carried out to investigate the potential effects of Chlorella vulgaris (CV) on testicular function and oxidant/antioxidant status in normal and deltamethrin-intoxicated rats. Forty adult male rats were drenched either with normal saline, CV (50 mg/kg), deltamethrin (DM) (3 mg/kg), or CV combined with DM, daily for 8 weeks. At the end of the protocol, the epididymal sperm quality was evaluated and the testicular superoxide dismutase (SOD), catalase enzyme (CAT) and malondialdehyde (MDA), and the serum testosterone levels were estimated. Read More

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November 2018
2 Reads

Ectopic Organogenesis after Allotransplantation of Freshly Removed or Cryopreserved Neonatal Testicle under the Renal Capsule in Rats.

Bull Exp Biol Med 2018 Dec 28;166(2):268-273. Epub 2018 Nov 28.

All-Russian Institute of Scientific and Technical Information, Russian Academy of Sciences, Moscow, Russia.

In experiments on white outbred male rats, a freshly removed (20 experiments) or cryopreserved (10 experiments) testicle from newborn rats (1-2 days after birth) was transplanted under the renal capsule after bilateral orchiectomy. In all experiments with transplantation of freshly removed testicle, it was engrafted. In 3 months, histological examination revealed the formation of mature seminiferous tubules, but spermatogenesis was blocked at the stage of spermatogonia; groups of proliferating Leydig cells in the loose connective tissue between the tubules were also seen. Read More

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December 2018
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The protective effect of neonatal oral administration of oleanolic acid against the subsequent development of fructose-induced metabolic dysfunction in male and female rats.

Nutr Metab (Lond) 2018 20;15:82. Epub 2018 Nov 20.

1School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parktown, Johannesburg, 2193 South Africa.

Background: Consumption of fructose-rich diets has been implicated in the increasing global prevalence of metabolic syndrome (MetS). Interventions during periods of early ontogenic developmental plasticity can cause epigenetic changes which program metabolism for positive or negative health benefits later in life. The phytochemical oleanolic acid (OA) possesses anti-diabetic and anti-obesity effects. Read More

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November 2018
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Peroxiredoxin 6: The Protector of Male Fertility.

Antioxidants (Basel) 2018 Nov 24;7(12). Epub 2018 Nov 24.

Departments of Surgery (Urology Division) and Pharmacology and Therapeutics, Faculty of Medicine, McGill University and the Research Institute, McGill University Health Centre, Montréal, QC H4A 3J1, Canada.

The spermatozoon is a terminal cell with the unique purpose of delivering the paternal genome to the oocyte during fertilization. Once spermatozoa enter into the female reproductive tract, they count on only the antioxidant protection that they received during spermatogenesis and epididymal maturation. Peroxiredoxins (PRDXs), particularly PRDX6, are important players in the antioxidant protection and regulation of reactive oxygen species (ROS) levels in spermatozoa. Read More

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November 2018
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Comparison of the characteristics of chinchilla epidydimal semen after collection, storage at 5°C and cryopreservation.

Reprod Domest Anim 2018 Nov;53 Suppl 3:29-36

Department of Reproduction and Clinic of Farm Animals, Wrocław University of Environmental and Life Sciences, Wrocław, Poland.

The aim of the study was to compare the characteristics of chinchilla epididymal sperm: fresh, stored at liquid state and cryopreserved. Epididymal spermatozoa obtained from 11 males were assessed for subjective motility, concentration, motility parameters measured by CASA, viability, morphology, membrane integrity, acrosome integrity, mitochondrial potential, lipid peroxidation, chromatin structure, apoptotic changes and capacitation. Then half of the spermatozoa were stored at 5°C for 30 hr, and the second half was cryopreserved. Read More

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November 2018
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Prevascularization of collagen-glycosaminoglycan scaffolds: stromal vascular fraction versus adipose tissue-derived microvascular fragments.

J Biol Eng 2018 13;12:24. Epub 2018 Nov 13.

1Institute for Clinical & Experimental Surgery, Saarland University, 66421 Homburg/Saar, Germany.

Background: The seeding of scaffolds with the stromal vascular fraction (SVF) of adipose tissue is a common prevascularization strategy in tissue engineering. Alternatively, adipose tissue-derived microvascular fragments (ad-MVF) may serve as vascularization units. In contrast to SVF single cells, they represent a mixture of intact arteriolar, capillary and venular vessel segments. Read More

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November 2018

Late ascended testes: is non-orthotopic gubernacular insertion a confirmation of an alternative embryological etiology?

J Pediatr Urol 2018 Oct 25. Epub 2018 Oct 25.

Department of Urology, Ghent University Hospital, Ghent, Belgium. Electronic address:

Introduction: Re-ascended testes account for a proportion of all undescended testes (UDTs); one main hypothesis relating to their etiology relates to a patent processus vaginalis peritonei. The aim was to investigate gubernacular insertion points in boys with late ascended testis as a possible guide to an alternative embryological etiology.

Patients And Methods: Patients with proven ascended testes were recruited from four different pediatric urology centers between May 2016 and September 2017. Read More

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October 2018
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Development of a standard protocol for quantitative polymerase chain reaction to detect adenovirus 36, which is associated with obesity.

Acta Virol 2018 ;62(4):350-359

It has been previously reported that adenovirus 36 (Ad36) infection is associated with obesity in humans and other animals. However, there is no clinically available standard protocol to detect Ad36 DNA. In this study, we developed a method for quantitative and rapid detection of Ad36 DNA. Read More

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January 2018

Royal jelly protection on flunixin meglumine-induced spermiotoxicity and testicular degeneration in mice.

Pol J Vet Sci 2018 Sep;21(3):497-506

Department of Pathology, Faculty of Veterinary Medicine, Harran University, Sanliurfa 63300, Turkey.

Current study was designed to investigate the protective effects of royal jelly on Flunixin me- glumine (FM)-induced spermiotoxicity related to sperm concentration, abnormal spermatozoa count and histopathological changes in mice testis. The subjects were divided into five groups according to FM and/or royal jelly intake: Control group; group 1, FM alone (25 mg/kg, im); group 2, combination of FM (25 mg/kg, im) and royal jelly (200 mg/kg, oral); group 3, FM alone (50 mg/kg, im); and group 4, combination of FM (50 mg/kg, im) and royal jelly (200 mg/kg, oral). The animals were fed once daily for 15 days and they were sacrificed last day. Read More

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September 2018
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