J Autoimmun 2020 12 4;115:102528. Epub 2020 Aug 4.
Department of Dermatology, Allergy, and Venereology, University of Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany; Center for Research on Inflammation of the Skin (CRIS), University of Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany. Electronic address:
Autoimmune diseases are defined by an immune response against a specific autoantigen, driven by antigen-specific T cells or antibodies. While the mechanisms resolving brief episodes of acute inflammation elicited by microbial components or tissue injury are well understood, the mechanisms resolving tissue inflammation in autoimmune diseases are still largely elusive. We have, therefore, addressed the mechanisms of resolution in IgG-mediated autoimmune diseases using a mouse model of the pemphigoid disease "bullous pemphigoid-like epidermolysis bullosa acquisita" (BP-like EBA) as prototypical example. Read More