In vitro and in vivo models to investigate the pathomechanisms and novel treatments for pemphigoid diseases.
Exp Dermatol 2017 Aug 20. Epub 2017 Aug 20.
Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Pemphigoid diseases (PD) are a subgroup of rare acute or chronic autoimmune skin disorders characterized and caused by autoantibodies directed against distinct structural components of the dermal-epidermal junction. Binding of autoantibodies to their targets leads to the formation of blisters and erosions in patients. PDs comprise eight disorders for which the molecular target antigens have been identified. Read More