837 results match your criteria Epidermodysplasia Verruciformis


A 23-Year Follow-Up of a Patient with Gain-of-Function IkB-Alpha Mutation and Stable Full Chimerism After Hematopoietic Stem Cell Transplantation.

J Clin Immunol 2020 Jul 2. Epub 2020 Jul 2.

University Department of Pediatrics, Unit of Immune and Infectious Diseases, Childrens' Hospital Bambino Gesù, Piazza S. Onofrio 4, Rome, Italy.

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http://dx.doi.org/10.1007/s10875-020-00780-zDOI Listing

Acquired Epidermodysplasia Verruciformis in the Setting of Renal Transplant.

Am J Dermatopathol 2020 Jun 15. Epub 2020 Jun 15.

Trillium Creek Dermatology and Surgery Center, Medina, OH.

Epidermodysplasia verruciformis (EV) is a rare dermatologic condition that is clinically characterized by flat, cutaneous, verrucous papules, pityriasis versicolor-like lesions, and similar lichenoid papules. There are 2 forms of EV: a classic inherited genodermatosis and a secondary acquired form. EV predisposes individuals to infections with certain types of human papillomavirus virus and subsequently increases the risk of cutaneous squamous cell carcinoma. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001696DOI Listing

Claudin expression profile in flat wart and cutaneous squamous cell carcinoma in epidermodysplasia verruciformis.

Sci Rep 2020 Jun 9;10(1):9268. Epub 2020 Jun 9.

Departament of Dermatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.

Epidermodysplasia verruciformis (EV) is a genodermatosis related to human beta-papillomavirus (beta-HPV), with a high risk of cutaneous squamous cell carcinoma (cSCC). Claudins are transmembrane proteins expressed in epithelia and may be altered during carcinogenesis. For a better understanding of the role of beta-HPV in cutaneous carcinogenesis, this claudin expression study was conducted on lesions of patients with and without EV. Read More

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http://dx.doi.org/10.1038/s41598-020-66065-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283482PMC

Visual Dermatology: Epidermodysplasia Verruciformis.

J Cutan Med Surg 2020 Jun 1:1203475420931775. Epub 2020 Jun 1.

72924 Department of Dermatology, Venereology, and Leprosy, R.G.Kar Medical College, Kolkata, West Bengal, India.

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http://dx.doi.org/10.1177/1203475420931775DOI Listing
June 2020
0.714 Impact Factor

Human genetic dissection of papillomavirus-driven diseases: new insight into their pathogenesis.

Authors:
Vivien Béziat

Hum Genet 2020 Jun 20;139(6-7):919-939. Epub 2020 May 20.

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) UMR-1163, Necker Hospital for Sick Children, Paris, EU, France.

Human papillomaviruses (HPVs) infect mucosal or cutaneous stratified epithelia. There are 5 genera and more than 200 types of HPV, each with a specific tropism and virulence. HPV infections are typically asymptomatic or result in benign tumors, which may be disseminated or persistent in rare cases, but a few oncogenic HPVs can cause cancers. Read More

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http://dx.doi.org/10.1007/s00439-020-02183-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291412PMC

Beta human papillomaviruses infection and skin carcinogenesis.

Rev Med Virol 2020 Mar 30:e2104. Epub 2020 Mar 30.

Department of Neurosciences, Section of Otolaryngology, University of Padova, Padova, Italy.

During the last decade, the worldwide incidence of keratinocyte carcinomas (KC) has increased significantly. They are now the most common malignancy, representing approximately 30% of all cancers. The role of ultraviolet (UV) radiation as a major environmental risk factor for skin cancers is well recognized. Read More

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http://dx.doi.org/10.1002/rmv.2104DOI Listing

["Typical" epidermodysplasia verruciformis: Identification of a molecular complex regulating keratinocyte innate immunity].

Authors:
O Dereure

Ann Dermatol Venereol 2020 Feb 14;147(2):168-169. Epub 2020 Jan 14.

Département de dermatologie et INSERM U1058 « Pathogénèse et contrôle des infections chroniques », université de Montpellier, 80, avenue Augustin-Fliche, 34295 Montpellier cedex 5, France. Electronic address:

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http://dx.doi.org/10.1016/j.annder.2019.12.006DOI Listing
February 2020

Progressive Flat Papules on the Extremities: Epidermodysplasia Verruciformis.

Skinmed 2019 1;17(6):410-412. Epub 2019 Nov 1.

Alaska Center for Dermatology, Anchorage, AK.

During a US military medical mission to Guatemala, a 32-year-old woman with Fitzpatrick skin type IV presented with a chief complaint of numerous white spots on her arms and legs. She had initially noticed a few white spots 25 years earlier, and stated that they had been continuously increasing in number ever since. The lesions were asymptomatic and had not been previously treated; this encounter was the first time she had ever seen a physician. Read More

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November 2019

Novel dermoscopic features of pityriasis versicolor-like macules in epidermodysplasia verruciformis.

Pediatr Dermatol 2020 Jan 23;37(1):230-232. Epub 2019 Oct 23.

IQRAA Aesthetics, Department of Dermatology, IQRAA International Hospital and Research Centre, Calicut, India.

Epidermodysplasia verruciformis (EV) manifests early in childhood as pityriasis versicolor (PV)-like macules on sun-exposed sites such as the face. These hypopigmented lesions closely resemble commoner pediatric dermatoses such as PV or pityriasis alba. In this report of two cases, we describe the distinguishing dermoscopic features of PV-like macules in EV. Read More

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http://dx.doi.org/10.1111/pde.14031DOI Listing
January 2020
1 Read
1.520 Impact Factor

Acquired epidermodysplasia verruciformis: a 10-year anniversary update.

Br J Dermatol 2020 Mar 24;182(3):790-792. Epub 2019 Nov 24.

Department of Dermatology, McGovern Medical School at UTHealth, Houston, 77030, TX, U.S.A.

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http://dx.doi.org/10.1111/bjd.18549DOI Listing
March 2020
2 Reads

Verrucous lesions in an HIV-positive man.

JAAD Case Rep 2019 Sep 3;5(9):825-827. Epub 2019 Sep 3.

Department of Dermatology, University of Maryland School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1016/j.jdcr.2019.06.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731379PMC
September 2019
2 Reads

HPV8 activates cellular gene expression mainly through Sp1/3 binding sites.

Virology 2019 09 1;535:136-143. Epub 2019 Jul 1.

Institute of Virology, University of Cologne, Faculty of Medicine and University Hospital of Cologne, Germany. Electronic address:

The human papillomavirus type 8 (HPV8) is associated with skin cancer development. The goal of this study was to investigate the effects of HPV8 oncoproteins on cellular gene expression and the identification of key regulators. We performed affymetrix microarray analyses to identify differentially expressed genes and common sequence motifs and identified Sp1/3 binding sites as being crucial. Read More

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http://dx.doi.org/10.1016/j.virol.2019.06.019DOI Listing
September 2019
7 Reads

New biomarkers of human papillomavirus infection in epidermodysplasia verruciformis.

Ann Diagn Pathol 2019 Jun 23;40:81-87. Epub 2019 Apr 23.

Cornell Medical Center, United States of America.

The cause of epidermodysplasia verruciformis is infection by human papillomavirus, usually types 5 or 8, and it exhibits a high potential for malignant transformation. The diagnostic histologic features of epidermodysplasia verruciformis are not always present and can be mimicked by non-viral diseases. The purpose of this study was to interrogate such lesions for new potential biomarkers to aid in the diagnostic accuracy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10929134193012
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http://dx.doi.org/10.1016/j.anndiagpath.2019.04.010DOI Listing
June 2019
11 Reads

Multiple flat-topped scaly violaceous papules.

Dermatol Online J 2019 Mar 15;25(3). Epub 2019 Mar 15.

Texas A & M University College of Medicine, College Station, Texas.

Epidermodysplasia verruciformis (EV) is an autosomal recessive genodermatosis characterized by susceptibility to beta-genus human papillomavirus (HPV) infection. Owing to TMC6/EVER1 and TMC8/EVER2 mutations that lead to abnormal transmembrane channels in the endoplasmic reticulum involved in immunological pathways, keratinocytes cannot combat infection from non-pathogenic HPV strains. Mutations involving RHOH, MST-1, CORO1A, and IL-7 have also been associated with EV in patients without TMC6 or TMC8 mutations. Read More

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March 2019
34 Reads

Cross-talk of cutaneous beta human papillomaviruses and the immune system: determinants of disease penetrance.

Philos Trans R Soc Lond B Biol Sci 2019 05;374(1773):20180287

2 Institute of Virology, Saarland University Medical Center , Kirrbergerstr. Building 47, 66421 Homburg/Saar , Germany.

Human papillomaviruses (HPVs) infect the epithelia of skin or mucosa, where they can induce hyperproliferative lesions. More than 220 different HPV types have been characterized and classified into five different genera. Mucosal high-risk HPVs are causative for cancers of the anogenital region and oropharynx. Read More

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http://dx.doi.org/10.1098/rstb.2018.0287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501898PMC
May 2019
9 Reads

The Protein Tyrosine Phosphatase H1 PTPH1 Supports Proliferation of Keratinocytes and is a Target of the Human Papillomavirus Type 8 E6 Oncogene.

Cells 2019 03 14;8(3). Epub 2019 Mar 14.

Institute of Virology, University of Cologne, Faculty of Medicine and University Hospital of Cologne,Fürst-Pückler-Strasse 56, 50935 Cologne, Germany.

Human papillomaviruses (HPV) replicate their DNA in the suprabasal layer of the infected mucosa or skin. In order to create a suitable environment for vegetative viral DNA replication HPV delay differentiation and sustain keratinocyte proliferation that can lead to hyperplasia. The mechanism underlying cell growth stimulation is not well characterized. Read More

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http://dx.doi.org/10.3390/cells8030244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468676PMC
March 2019
14 Reads

Dermoscopic and reflectance confocal microscopic features of epidermodysplasia verruciformis.

J Dermatol 2019 08 25;46(8):e272-e273. Epub 2019 Feb 25.

Department of Pathology, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.

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http://dx.doi.org/10.1111/1346-8138.14824DOI Listing
August 2019
12 Reads

Inherited Interleukin 2-Inducible T-Cell (ITK) Kinase Deficiency in Siblings With Epidermodysplasia Verruciformis and Hodgkin Lymphoma.

Clin Infect Dis 2019 05;68(11):1938-1941

Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College, and Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania.

Biallelic mutations in the ITK gene cause a T-cell primary immunodeficiency with Epstein-Barr virus (EBV)-lymphoproliferative disorders. We describe a novel association of a homozygous ITK mutation with β-human papillomavirus (HPV)-positive epidermodysplasia verruciformis. Thus, loss of function in ITK can result in broad dysregulation of T-cell responses to oncogenic viruses, including β-HPV and EBV. Read More

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https://academic.oup.com/cid/advance-article/doi/10.1093/cid
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http://dx.doi.org/10.1093/cid/ciy942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317279PMC
May 2019
33 Reads
8.886 Impact Factor

Diagnosis of epidermodysplasia verruciformis: Two cases highlighting the role of direct HPV L1 gene sequencing.

J Cutan Pathol 2019 Jun 28;46(6):436-441. Epub 2019 Mar 28.

Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota.

Epidermodysplasia verruciformis (EV) is a rare skin disease characterized by the development of multiple flat warts with the potential for malignant transformation. Patients are susceptible to human papillomavirus (HPV) infection that develops in a background of either a genetic or acquired immunodeficiency predisposing patients to infection with specific HPV types that are ubiquitous but generally non-pathogenic in healthy individuals. There is no standard clinical methodology for determining the causative HPV from patients with suspected EV. Read More

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http://dx.doi.org/10.1111/cup.13444DOI Listing
June 2019
9 Reads

Epidermodysplasia verruciformis in a young adult with activated PI3Kδ syndrome.

JAAD Case Rep 2019 Feb 31;5(2):195-197. Epub 2019 Jan 31.

Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama.

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http://dx.doi.org/10.1016/j.jdcr.2018.10.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357544PMC
February 2019
8 Reads

Beta Human Papillomavirus and Associated Diseases.

Acta Cytol 2019 23;63(2):100-108. Epub 2019 Jan 23.

Infections and Cancer Biology Group, International Agency for Research on Cancer, World Health Organization, Lyon, France.

The cutaneous human papillomavirus (HPV), mostly from β- and γ-HPV genus, is ubiquitously distributed throughout the human body and may be part of the commensal flora. The association of β-HPVs and cutaneous squamous cell carcinoma (cSCC) development was initially reported in patients with the rare genetic disorder Epidermodysplasia verruciformis. Likewise, immunosuppressed organ transplant recipients have an increased susceptibility to β-HPV infections in the skin as well as to cSCC development. Read More

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https://www.karger.com/Article/FullText/492659
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http://dx.doi.org/10.1159/000492659DOI Listing
May 2019
12 Reads

Skin Cancer Associated Genodermatoses: A Literature Review.

Acta Derm Venereol 2019 Apr;99(4):360-369

Department of Dermatology and Allergy Centre, Odense University Hospital, DK-5000 Odense, Denmark.

Skin cancer has become the most common type of cancer worldwide as a result of environmental exposure and medical treatments. A small group of patients are genetically predisposed to skin cancer and this article is intended as a diagnostic tool when encountering patients with multiple skin cancer lesions. The disorders are described with clinical characteristics, genetics and management. Read More

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http://dx.doi.org/10.2340/00015555-3123DOI Listing
April 2019
37 Reads

A Novel STK4 Mutation Presenting with Juvenile Idiopathic Arthritis and Epidermodysplasia Verruciformis.

J Clin Immunol 2019 01 5;39(1):11-14. Epub 2019 Jan 5.

Division of Allergy and Clinical Immunology, Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran.

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http://link.springer.com/10.1007/s10875-018-0586-8
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http://dx.doi.org/10.1007/s10875-018-0586-8DOI Listing
January 2019
19 Reads

Metagenomic Discovery of 83 New Human Papillomavirus Types in Patients with Immunodeficiency.

mSphere 2018 12 12;3(6). Epub 2018 Dec 12.

Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, Maryland, USA.

Several immunodeficiencies are associated with high susceptibility to persistent and progressive human papillomavirus (HPV) infection leading to a wide range of cutaneous and mucosal lesions. However, the HPV types most commonly associated with such clinical manifestations in these patients have not been systematically defined. Here, we used virion enrichment, rolling circle amplification, and deep sequencing to identify circular DNA viruses present in skin swabs and/or wart biopsy samples from 48 patients with rare genetic immunodeficiencies, including patients with warts, hypogammaglobulinemia, infections, myelokathexis (WHIM) syndrome, or epidermodysplasia verruciformis (EV). Read More

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http://msphere.asm.org/lookup/doi/10.1128/mSphereDirect.0064
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http://dx.doi.org/10.1128/mSphereDirect.00645-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291628PMC
December 2018
59 Reads

A CIB1 Splice-Site Founder Mutation in Families with Typical Epidermodysplasia Verruciformis.

J Invest Dermatol 2019 05 29;139(5):1195-1198. Epub 2018 Nov 29.

Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College, and Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X183289
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http://dx.doi.org/10.1016/j.jid.2018.11.011DOI Listing
May 2019
44 Reads
7.216 Impact Factor

[Epidermodysplasia verruciformis: about a case].

Pan Afr Med J 2018 29;30:78. Epub 2018 May 29.

Hôpital Civil Tétouan, Tétouan, Maroc.

Epidermodysplasia verruciformis, also known as Lewandowsky-Lutz syndrome or tree man disease is a rare genetic skin disorder. It is characterized by abnormal susceptibility of the skin coating to human papillomaviruses (HPVs). It commonly affects people between the ages of 4 and 8, most often before the age of 20 years but it may exceptionally occur later. Read More

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http://dx.doi.org/10.11604/pamj.2018.30.78.16058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191268PMC
October 2018
12 Reads

[Low-dose prophylactic oral isotretinoin treatment for 18 years in a patient with epidermodysplasia verruciformis and numerous squamous cell carcinomas].

Hautarzt 2018 Dec;69(12):1033-1038

Klinik für Hautkrankheiten und Allergologie, HELIOS Vogtland-Klinikum Plauen GmbH, Postfach 100153, 08505, Plauen, Deutschland.

Epidermodysplasia verruciformis (also known as Lewandowsky-Lutz dysplasia) is an extremely rare autosomal recessive genodermatosis, in which the skin is unusually sensitive to human papilloma viruses (HPV). It is associated with a high risk of developing non-melanocytic skin tumors. Treatment with keratolytic retinoids is currently considered to be the most effective therapy. Read More

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http://dx.doi.org/10.1007/s00105-018-4267-6DOI Listing
December 2018
10 Reads

Acquired epidermodysplasia verruciformis in setting of tumor necrosis factor-α inhibitor therapy.

JAAD Case Rep 2018 Sep 14;4(8):805-807. Epub 2018 Sep 14.

Department of Dermatology, University of Minnesota, Minneapolis, Minnesota.

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http://dx.doi.org/10.1016/j.jdcr.2018.05.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141641PMC
September 2018
11 Reads

A novel approach to the classification of epidermodysplasia verruciformis.

Int J Dermatol 2018 Nov 29;57(11):1344-1350. Epub 2018 Aug 29.

Department of Dermatology, University of Texas Health Science Center at Houston, Houston, TX, USA.

Background: Epidermodysplasia verruciformis (EV) is a rare genodermatosis that causes disseminated eruptions of hypo- or hyperpigmented macules and wart-like papules that can coalesce and scale. It is uniquely characterized by an increased susceptibility to specific human papillomavirus (HPV) genotypes. Classically, EV is associated with mutations of the EVER1/TMC6 and EVER2/TMC8 genes. Read More

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http://dx.doi.org/10.1111/ijd.14196DOI Listing
November 2018
15 Reads

An nonsense somatic mutation in a female with epidermodysplasia verruciformis (Tree Man Syndrome).

Clin Case Rep 2018 Aug 5;6(8):1426-1430. Epub 2018 Jun 5.

The Centre for Applied Genomics The Hospital for Sick Children Toronto ON Canada.

Epidermodysplasia verruciformis (EV) is an extremely rare hereditary skin disease characterized by an abnormal susceptibility to the human papilloma virus (HPV) with an increased risk of cutaneous malignancy. Here we report the first female severe EV case in Bangladesh, a 10-year-old girl with a nonsense somatic mutation impacting gene. Read More

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http://dx.doi.org/10.1002/ccr3.1595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099040PMC
August 2018
42 Reads

Epidemiology and biology of cutaneous human papillomavirus.

Clinics (Sao Paulo) 2018 08 20;73(suppl 1):e489s. Epub 2018 Aug 20.

Centro de Investigação Translacional em Oncologia, Instituto do Cancer do Estado de Sao Paulo (ICESP), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.

Cutaneous human papillomaviruses (HPVs) include β- and γ-HPVs, in addition to a small fraction of α-HPVs. β-HPVs were first isolated from patients with the rare genetic disorder Epidermodysplasia verruciformis, and they are associated with the development of nonmelanoma skin cancer at sun-exposed skin sites in these individuals. Organ transplant recipients also have greater susceptibility to β-HPV infection of the skin and an increased risk of developing nonmelanoma skin cancer. Read More

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http://dx.doi.org/10.6061/clinics/2018/e489sDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097087PMC
August 2018
7 Reads

HPV: CIB1 is for EVER and EVER.

J Exp Med 2018 09 1;215(9):2229-2231. Epub 2018 Aug 1.

Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD

In this issue, de Jong et al. (https://doi.org/10. Read More

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http://dx.doi.org/10.1084/jem.20181207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122965PMC
September 2018
31 Reads

The human CIB1-EVER1-EVER2 complex governs keratinocyte-intrinsic immunity to β-papillomaviruses.

J Exp Med 2018 09 1;215(9):2289-2310. Epub 2018 Aug 1.

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY

Patients with epidermodysplasia verruciformis (EV) and biallelic null mutations of (encoding EVER1) or (EVER2) are selectively prone to disseminated skin lesions due to keratinocyte-tropic human β-papillomaviruses (β-HPVs), which lack E5 and E8. We describe EV patients homozygous for null mutations of the gene encoding calcium- and integrin-binding protein-1 (CIB1). CIB1 is strongly expressed in the skin and cultured keratinocytes of controls but not in those of patients. Read More

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http://dx.doi.org/10.1084/jem.20170308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122964PMC
September 2018
44 Reads
1 Citation
12.520 Impact Factor

Epidermodysplasia Verruciformis: Genetic Heterogeneity and EVER1 and EVER2 Mutations Revealed by Genome-Wide Analysis.

J Invest Dermatol 2019 01 20;139(1):241-244. Epub 2018 Jul 20.

Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College and Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X183236
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http://dx.doi.org/10.1016/j.jid.2018.07.010DOI Listing
January 2019
33 Reads
1 Citation
7.220 Impact Factor

Malignant degeneration of diffuse intertriginous flat warts in a patient with AIDS.

JAAD Case Rep 2018 Jul 7;4(6):562-564. Epub 2018 Jun 7.

Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1016/j.jdcr.2018.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041375PMC
July 2018
27 Reads

Epidermodysplasia Verruciformis: Inborn Errors of Immunity to Human Beta-Papillomaviruses.

Front Microbiol 2018 12;9:1222. Epub 2018 Jun 12.

Department of Biomedicine, University Hospital of Basel, University of Basel, Basel, Switzerland.

Epidermodysplasia verruciformis (EV) is an autosomal recessive skin disorder with a phenotype conditional on human beta-papillomavirus (beta-HPV) infection. Such infections are common and asymptomatic in the general population, but in individuals with EV, they lead to the development of plane wart-like and red or brownish papules or pityriasis versicolor-like skin lesions, from childhood onwards. Most patients develop non-melanoma skin cancer (NMSC), mostly on areas of UV-exposed skin, from the twenties or thirties onwards. Read More

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http://dx.doi.org/10.3389/fmicb.2018.01222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005841PMC
June 2018
48 Reads

Characterization of a new genotype of Betapapillomavirus HPV 17 through L1, E7, E7 and LCR sequences.

Acta Virol 2018;62(2):172-178

Human papillomavirus (HPV) exhibits epithelial and mucosal tropism. HPV type 17 belongs to the Betapapillomavirus genus and molecular cloning experiments have identified two subtypes (17a and 17b) isolated from epidermodysplasia verruciformis (EV). HPV subtypes are characterized by dissimilarities from 2 to 10% at the nucleotide level from their referenced HPV. Read More

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http://dx.doi.org/10.4149/av_2018_208DOI Listing
December 2018
5 Reads

Inhibition of TGF-β and NOTCH Signaling by Cutaneous Papillomaviruses.

Front Microbiol 2018 8;9:389. Epub 2018 Mar 8.

Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA, United States.

Infections with cutaneous papillomaviruses have been linked to cutaneous squamous cell carcinomas that arise in patients who suffer from a rare genetic disorder, epidermodysplasia verruciformis, or those who have experienced long-term, systemic immunosuppression following organ transplantation. The E6 proteins of the prototypical cutaneous human papillomavirus (HPV) 5 and HPV8 inhibit TGF-β and NOTCH signaling. The papillomavirus 1, MmuPV1, infects laboratory mouse strains and causes cutaneous skin warts that can progress to squamous cell carcinomas. Read More

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http://dx.doi.org/10.3389/fmicb.2018.00389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852067PMC
March 2018
14 Reads

Chronic Inflammatory Microenvironment in Epidermodysplasia Verruciformis Skin Lesions: Role of the Synergism Between HPV8 E2 and C/EBPβ to Induce Pro-Inflammatory S100A8/A9 Proteins.

Front Microbiol 2018 7;9:392. Epub 2018 Mar 7.

Institute of Virology, Saarland University Medical Center, Homburg, Germany.

Persistent genus β-HPV (human papillomavirus) infection is a major co-factor for non-melanoma skin cancer in patients suffering from the inherited skin disease epidermodysplasia verruciformis (EV). Malignant EV lesions are particularly associated with HPV type 5 or 8. There is clinical and molecular evidence that HPV8 actively suppresses epithelial immunosurveillance by interfering with the recruitment of Langerhans cells, which may favor viral persistence. Read More

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http://dx.doi.org/10.3389/fmicb.2018.00392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845987PMC
March 2018
74 Reads
3.941 Impact Factor

Identification and characterization of two novel Gammapapillomavirus genomes in skin of an immunosuppressed Epidermodysplasia Verruciformis patient.

Virus Res 2018 04 8;249:66-68. Epub 2018 Mar 8.

Infections and Cancer Biology Group, International Agency for Research on Cancer, Lyon, France. Electronic address:

Two novel human gamma-papillomavirus genomes (HPV_MTS3, and HPV_MTS4) were isolated from the skin of an immunosuppressed, late-onset Epidermodysplasia Verruciformis patient and fully cloned. The L1 open reading frames of HPV_MTS3 and HPV_MTS4 were 77% and 91% identical to their closest HPV full genome isolates w18c39 and EV03c60, which belong to the species gamma-22and gamma-7 of the genus Gammapapillomavirus, respectively. Read More

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http://dx.doi.org/10.1016/j.virusres.2018.03.003DOI Listing
April 2018
26 Reads

Cutaneous squamous cell carcinoma with epidermodysplasia verruciformis-like features in a patient with Schimke immune-osseous dysplasia.

J Cutan Pathol 2018 06 3;45(6):465-467. Epub 2018 Apr 3.

Department of Dermatology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

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http://doi.wiley.com/10.1111/cup.13139
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http://dx.doi.org/10.1111/cup.13139DOI Listing
June 2018
22 Reads

Zinc and Skin Disorders.

Nutrients 2018 Feb 11;10(2). Epub 2018 Feb 11.

Department of Dermatology, Faculty of Medicine, University of Yamanashi, Yamanashi 409-3898, Japan.

The skin is the third most zinc (Zn)-abundant tissue in the body. The skin consists of the epidermis, dermis, and subcutaneous tissue, and each fraction is composed of various types of cells. Firstly, we review the physiological functions of Zn and Zn transporters in these cells. Read More

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http://www.mdpi.com/2072-6643/10/2/199
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http://dx.doi.org/10.3390/nu10020199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852775PMC
February 2018
24 Reads

[Cutaneous infections: Pathologist's role in unusual or atypical situations].

Ann Pathol 2018 Feb 26;38(1):20-30. Epub 2017 Dec 26.

Département de pathologie, groupe hospitalier Henri-Mondor, AP-HP, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil, France. Electronic address:

In infectious pathology, the gold standard consists of the detection of the pathogen within the sample. Identification of the pathogen is often difficult despite the presence of few and inexpensive tools, such, as special stain, immunohistochemistry, or in situ hybridization specific of the pathogen. In infectious pathology, there are morphological signs, which can guide us towards an etiology. Read More

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http://dx.doi.org/10.1016/j.annpat.2017.10.016DOI Listing
February 2018
7 Reads

Epidermodysplasia verruciformis in an adult patient with a germline Interleukin-2 inducible T-Cell Kinase mutation and lymphoma: the case of inherited versus acquired.

J Eur Acad Dermatol Venereol 2018 Jun 8;32(6):e240-e241. Epub 2018 Jan 8.

Dermatology Department, Hôpital Saint Louis, 1 avenue Claude Vellefaux, 75010, Paris, France.

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http://dx.doi.org/10.1111/jdv.14756DOI Listing
June 2018
13 Reads

Loss of Genome Fidelity: Beta HPVs and the DNA Damage Response.

Front Microbiol 2017 15;8:2250. Epub 2017 Nov 15.

Division of Biology, Kansas State University, Manhattan, KS, United States.

While the role of genus alpha human papillomaviruses in the tumorigenesis and tumor maintenance of anogenital and oropharyngeal cancers is well-established, the role of genus beta human papilloviruses (β-HPVs) in non-melanoma skin cancers (NMSCs) is less certain. Persistent β-HPV infections cause NMSCs in sun-exposed skin of people with a rare genetic disorder, epidermodysplasia verruciformis. However, β-HPV infections in people without epidermodysplasia verruciformis are typically transient. Read More

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http://journal.frontiersin.org/article/10.3389/fmicb.2017.02
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http://dx.doi.org/10.3389/fmicb.2017.02250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5694782PMC
November 2017
13 Reads

HPV8-E6 Interferes with Syntenin-2 Expression through Deregulation of Differentiation, Methylation and Phosphatidylinositide-Kinase Dependent Mechanisms.

Front Microbiol 2017 8;8:1724. Epub 2017 Sep 8.

Institute of Virology, University of CologneCologne, Germany.

The E6 oncoproteins of high-risk human papillomaviruses (HPV) of genus alpha contain a short peptide sequence at the carboxy-terminus, the PDZ binding domain, with which they interact with the corresponding PDZ domain of cellular proteins. Interestingly, E6 proteins from papillomaviruses of genus beta (betaPV) do not encode a comparable PDZ binding domain. Irrespective of this fact, we previously showed that the E6 protein of HPV8 (betaPV type) could circumvent this deficit by targeting the PDZ protein Syntenin-2 through transcriptional repression (Lazic et al. Read More

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http://dx.doi.org/10.3389/fmicb.2017.01724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609557PMC
September 2017
18 Reads

[The CXCL12/CXCR4 signaling pathway in the control of human papillomavirus infection: new susceptibility factors in viral pathogenesis].

Med Sci (Paris) 2017 Aug-Sep;33(8-9):691-694. Epub 2017 Sep 18.

Inflammation, chimiokines et immunopathologie, Inserm UMR 996, Fac. de médecine-Univ Paris-Sud, Université Paris-Saclay, Clamart, France.

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http://dx.doi.org/10.1051/medsci/20173308002DOI Listing
April 2019
78 Reads

Epidermodysplasia verruciformis: three case reports and a brief review.

Acta Dermatovenerol Alp Pannonica Adriat 2017 09;26(3):59-61

Department of Dermatology, Safdarjung Hospital, New Delhi, India.

Epidermodyplasia verruciformis (EV) is a rare heritable disease that is characterized by an increased susceptibility to infection with specific human papillomavirus (HPV) types due to a defect in cell-mediated immune response to HPV infection. Widespread infection with HPV is responsible for the development of wart-like lesions and pityriasis versicolor-like spots. These individuals have a lifelong risk of developing cutaneous malignancies, especially Bowen's disease and squamous cell carcinoma, mainly in sun-exposed parts. Read More

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http://dx.doi.org/10.15570/actaapa.2017.19DOI Listing
September 2017
11 Reads