896 results match your criteria Epidermodysplasia Verruciformis

RG2-VLP: a Vaccine Designed to Broadly Protect against Anogenital and Skin Human Papillomaviruses Causing Human Cancer.

J Virol 2022 Jun 15:e0056622. Epub 2022 Jun 15.

Department of Pathology, Johns Hopkins Universitygrid.21107.35, Baltimore, Maryland, USA.

The family of human papillomaviruses (HPV) includes over 400 genotypes. Genus α genotypes generally infect the anogenital mucosa, and a subset of these HPV are a necessary, but not sufficient, cause of cervical cancer. Of the 13 high-risk (HR) and 11 intermediate-risk (IR) HPV associated with cervical cancer, genotypes 16 and 18 cause 50% and 20% of cases, respectively, whereas HPV16 dominates in other anogenital and oropharyngeal cancers. Read More

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HPV-57 Verruca Vulgaris Mimicking Epidermodysplasia Verruciformis.

Am J Dermatopathol 2022 May 30. Epub 2022 May 30.

Department of Dermatology, Cook County Hospital and Health System, Department of Dermatology, Chicago, IL.

Abstract: Human papilloma virus (HPV) is the causative agent for a variety of cutaneous lesions including verruca vulgaris (VV) and epidermodysplasia verruciformis (EDV). There are more than 200 known genotypes of HPV, and specific HPV types are associated with different clinical manifestations and malignant potentials. Herein, we describe a case of a 43-year-old immunocompetent woman who presented with morphologically distinct lesions that were most consistent with EDV on clinical examination. Read More

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A novel EVER1 polymorphism of epidermodysplasia verruciformis: Homozygous TMC6 c.718del.

JAAD Case Rep 2022 May 21;23:145-146. Epub 2022 Jan 21.

Department of Pathology and Laboratory Medicine, Saskatchewan Health Authority, Saskatoon, Canada.

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High-Risk Mucosal Human Papillomavirus 16 (HPV16) E6 Protein and Cutaneous HPV5 and HPV8 E6 Proteins Employ Distinct Strategies To Interfere with Interferon Regulatory Factor 3-Mediated Beta Interferon Expression.

J Virol 2022 05 27;96(10):e0187521. Epub 2022 Apr 27.

Equipe Signalisation Nucléaire, UMR 7242, CNRS, Université de Strasbourg, Ecole Supérieure de Biotechnologie de Strasbourg (ESBS), Illkirch, France.

Persistent infection with some mucosal α-genus human papillomaviruses (HPVs; the most prevalent one being HPV16) can induce cervical carcinoma, anogenital cancers, and a subset of head and neck squamous cell carcinoma (HNSCC). Cutaneous β-genus HPVs (such as HPV5 and HPV8) associate with skin lesions that can progress into squamous cell carcinoma with sun exposure in Epidermodysplasia verruciformis patients and immunosuppressed patients. Here, we analyzed mechanisms used by E6 proteins from the α- and β-genus to inhibit the interferon-β (IFNB1) response. Read More

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Acquired epidermodysplasia verruciformis in a renal transplant patient: a case report.

Acta Dermatovenerol Alp Pannonica Adriat 2022 03;31(Suppl):S18-S20

Department of Dermatovenereology, Ljubljana University Medical Centre, Ljubljana, Slovenia.

Acquired epidermodysplasia verruciformis is a rare disease. It can develop in immunocompromised patients due to infection with human papillomaviruses. Because such patients are at high risk of developing cutaneous squamous cell carcinoma, timely diagnosis and regular monitoring of the patient is essential. Read More

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Eosinophilic homogeneous intracytoplasmic inclusion bodies: Unique viral cytopathic changes associated with epidermodysplasia verruciformis and human papillomavirus type 49.

J Cutan Pathol 2022 Jul 21;49(7):658-662. Epub 2022 Mar 21.

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Epidermodysplasia verruciformis (EDV) is a rare genodermatosis that predisposes affected individuals to persistent infection with certain types of human papillomavirus (HPV), particularly those that belong to the genus beta-HPV, including HPV-5 and HPV-8, which carry high oncogenic potential. There are three main HPV-related viral cytopathic changes in cutaneous verrucae in terms of intracytoplasmic inclusion bodies (ICBs), namely, granular, filamentous, and homogeneous type ICBs. To date, only HPV-4, HPV-60, and HPV-65 have been found in association with homogeneous ICBs. Read More

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Case Report: Altered NK Cell Compartment and Reduced CXCR4 Chemotactic Response of B Lymphocytes in an Immunodeficient Patient With HPV-Related Disease.

Front Immunol 2022 26;13:799564. Epub 2022 Jan 26.

Pediatric Immunopathology and Allergology Unit, Policlinico Tor Vergata, University of Tor Vergata, Rome, Italy.

The study of inborn errors of immunity (IEI) provides unique opportunities to elucidate the microbiome and pathogenic mechanisms related to severe viral infection. Several immunological and genetic anomalies may contribute to the susceptibility to develop Human Papillomavirus (HPV) pathogenesis. They include different acquired immunodeficiencies, or mutations underlying epidermodysplasia verruciformis (EV) syndrome and multiple IEI. Read More

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Epidermodysplasia verruciformis mimicking pityriasis versicolor.

Pediatr Investig 2021 Dec 16;5(4):325-326. Epub 2021 Aug 16.

Department of Dermatology Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing China.

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December 2021

Diffuse skin-colored papules in a child.

JAAD Case Rep 2022 Jan 7;19:7-9. Epub 2021 Nov 7.

Department of Pathology and Laboratory Medicine, Saskatchewan Health Authority, Labrador and Saskatoon, Saskatchewan, Canada.

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January 2022

Recalcitrant Warts, Epidermodysplasia Verruciformis, and the Tree-Man Syndrome: Phenotypic Spectrum of Cutaneous Human Papillomavirus Infections at the Intersection of Genetic Variability of Viral and Human Genomes.

J Invest Dermatol 2022 May 27;142(5):1265-1269. Epub 2021 Nov 27.

Department of Dermatology & Cutaneous Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA; Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. Electronic address:

Human papillomavirus (HPV) infections can cause common warts, which usually resolve spontaneously or become recalcitrant, resistant to multiple treatments. In rare cases, they transform into cutaneous giant horns resulting in the tree-man syndrome (TMS). Defective β-HPVs can cause flat warts in epidermodysplasia verruciformis (EV), a genetic disorder. Read More

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Multicentric Castleman disease in a DOCK8-deficient patient with Orf virus infection.

Pediatr Allergy Immunol 2022 01 18;33(1):e13666. Epub 2021 Nov 18.

Division of Pediatric Oncology, Department of Pediatrics, Hacettepe University, Ankara, Turkey.

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January 2022

Recurrent fungating tumor and a chronic rash in an immunosuppressed transgender patient: a case of Buschke-Lowenstein condyloma and epidermodysplasia verruciformis.

Dermatol Online J 2021 Aug 15;27(8). Epub 2021 Aug 15.

Department of Dermatology, Penn State Hershey Medical Center, Hershey, PA.

A transgender female in her 40s with history of HIV and testicular cancer status post-genital X-irradiation presented with a perianal mass and pruritic rash across her chest. Physical examination revealed a bulky, verrucous tumor protruding outward from the anus involving the medial buttocks. Examination of the chest and arms showed numerous guttate, pink, flat-topped papules coalescing into plaques. Read More

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Tattoo-Associated Viral Infections: A Review.

Philip R Cohen

Clin Cosmet Investig Dermatol 2021 23;14:1529-1540. Epub 2021 Oct 23.

Department of Dermatology, University of California, Davis Medical Center, Sacramento, CA, USA.

Tattoos, a decorative form of body art, are produced by inoculating pigment into the dermis. Tattoo-associated viral infections can be cutaneous and localized to the tattoo ink; however, viral pathogens acquired during inoculation can cause systemic disease. A comprehensive review of the literature only reveals a limited number of published reports regarding patients with tattoo-associated cutaneous viral lesions. Read More

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October 2021

Acquired epidermodysplasia verruciformis (AEV) in three children after cardiac transplantation: A case series and review of the literature.

Pediatr Dermatol 2021 Nov 20;38(6):1541-1545. Epub 2021 Oct 20.

Department of Dermatology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.

Acquired epidermodysplasia verruciformis (AEV) describes epidermodysplasia verruciformis developing in an immunocompromised host. There is limited information in the literature regarding AEV in the pediatric population; of the patients reported, most patients described had HIV, with only two reported cases of children who developed AEV post-transplantation. This case series describes three pediatric patients who developed AEV on immunosuppressant therapy following cardiac transplantation. Read More

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November 2021

Verruca Vulgaris Occurring on a Tattoo: Case Report and Review of Tattoo-Associated Human Papillomavirus Infections.

Philip R Cohen

Cureus 2021 Aug 30;13(8):e17575. Epub 2021 Aug 30.

Dermatology, University of California, Davis Medical Center, Sacramento, USA.

Cutaneous infections can occur on tattoos. Tattoo-associated viral infections can be caused by human papillomavirus. A verruca vulgaris developed on the tattoo of a 44-year-old woman; the viral lesion appeared 21 years after she received the tattoo and had been increasing in size during the prior five years. Read More

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Efflorescence of acquired epidermodysplasia verruciformis due to immune reconstitution inflammatory syndrome-like mechanisms following anti-HPV vaccination in a HIV-positive patient.

Int J STD AIDS 2022 01 11;33(1):94-96. Epub 2021 Oct 11.

Department of Medical Sciences, Dermatology Clinic and Surgical Pathology Section, 9314University of Turin, Torino, Italy.

Epidermodysplasia verruciformis (EV) is a rare cutaneous pre-cancerous condition characterized by presence of flat, scaly macules, verruca-like papillomatous papules, seborrheic keratosis-like lesions, and pink-red pityriasis versicolor-like macules. The disease is caused by abnormal susceptibility to certain specific beta-HPV subtypes, most commonly 5 and 8. Classic EV is genetically determined, but in immunocompromised individuals, an acquired form can occur. Read More

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January 2022

Lepromatous leprosy in a case of epidermodysplasia verruciformis - A coincidence or a result of defective cell-mediated immunity?

Int J Mycobacteriol 2021 Apr-Jun;10(2):210-213

Department of Dermatology, Base Hospital, Lucknow, Uttar Pradesh, India.

Epidermodysplasia verruciformis (EDV) is a rare, autosomal recessive, genetic disorder of immune dysregulation characterized by increased susceptibility to cutaneous human papilloma virus infections. It was first described by Lewandowsky and Lutz in 1922 as a form of epidermal nevus. Its association with skin cancers was proposed by Sullivan and Ellis in 1939. Read More

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October 2021

Human genetic and immunological dissection of papillomavirus-driven diseases: new insights into their pathogenesis.

Curr Opin Virol 2021 12 21;51:9-15. Epub 2021 Sep 21.

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) UMR-1163, Necker Hospital for Sick Children, Paris, France; University of Paris, Imagine Institute, Paris, France; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, USA.

Human papillomaviruses (HPVs) are responsible for cutaneous and mucosal lesions. Persistent HPV infection remains a leading cause of uterine cancer in women, but also of cutaneous squamous cell carcinoma in patients with epidermodysplasia verruciformis (EV), and of rare and devastating benign tumors, such as 'tree-man' syndrome. HPV infections are usually asymptomatic or benign in the general population. Read More

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December 2021

Epidermodysplasia verruciformis in Mohs micrographic surgery.

JAAD Case Rep 2021 Oct 18;16:41-43. Epub 2021 Aug 18.

Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia.

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October 2021

Case of epidermodysplasia verruciformis with a novel mutation of TMC8.

J Dermatol 2021 Nov 29;48(11):e568-e569. Epub 2021 Aug 29.

Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

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November 2021

Defects of the Innate Immune System and Related Immune Deficiencies.

Clin Rev Allergy Immunol 2021 Aug 21. Epub 2021 Aug 21.

Division of Pediatric Immunology, Allergy, and Rheumatology, Joe DiMaggio Children's Hospital, 1311 N 35th Ave, Suite 220, 33021, Hollywood, FL, USA.

The innate immune system is the host's first line of defense against pathogens. Toll-like receptors (TLRs) are pattern recognition receptors that mediate recognition of pathogen-associated molecular patterns. TLRs also activate signaling transduction pathways involved in host defense, inflammation, development, and the production of inflammatory cytokines. Read More

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TMC8 mutation in a Turkish family with epidermodysplasia verruciformis including laryngeal papilloma and recurrent skin carcinoma.

J Cosmet Dermatol 2022 May 20;21(5):2263-2267. Epub 2021 Aug 20.

Pediatric Immunology Department, Hacettepe University Faculty of Medicine, Ankara, Turkey.

The vast majority of primary immunodeficiencies (PIDs) occur due to the defects in cells originating from hematopoietic stem cells, while in some PIDs, there are defects in various genes responsible for non-leucocyte immune response such as seen in epidermodysplasia verruciformis (EV). EV caused by the mutations in TMC6, TMC8, and CIB1 genes is called "typical." "Atypical" EV may develop in patients with primary immunodeficiencies originating from hematopoietic stem cells, which include severe T-cell failure, caused by inactivating biallelic mutations of STK4, RHOH, CORO1A, ITK, TPP2, DCLRE1C, LCK, RASGRP1, or DOCK8 genes. Read More

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Acquired epidermodysplasia verruciformis: clinical presentation and treatment update.

Int J Dermatol 2021 Aug 17. Epub 2021 Aug 17.

Department of Dermatology, McGovern Medical School at UTHealth, Houston, Texas, USA.

Acquired epidermodysplasia verruciformis (AEV) is a form of epidermodysplasia verruciformis (EV) that is most commonly found in immunocompromised or immunosuppressed patients. EV is commonly associated with human papillomavirus (HPV), which is often found in EV and AEV lesions. Clinical presentation of AEV in patients with organ transplantation, HIV+, congenital HIV+, hematological diseases, and other iatrogenic immunosuppression are reviewed. Read More

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Identification and Splicing Characterization of Novel and Variants Associated With Epidermodysplasia Verruciformis in Three Chinese Families.

Front Genet 2021 27;12:712275. Epub 2021 Jul 27.

McKusick-Zhang Center for Genetic Medicine, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China.

: Epidermodysplasia verruciformis (EV) is a rare genodermatosis characterized by abnormal susceptibility to human beta papillomavirus infections and a particular propensity to develop non-melanoma skin cancers (NMSCs). The majority of EV cases are caused by biallelic null variants in , , and . This study aimed to identify disease-causing variants in three Chinese families with EV and to elucidate their molecular pathogenesis. Read More

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Acquired epidermodysplasia verruciformis or generalized verrucosis? A clinical and virological comparative study.

J Dermatol 2021 Sep 2;48(9):1414-1418. Epub 2021 Jul 2.

Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Few articles have described the difference between epidermodysplasia verruciformis (EV) and generalized verrucosis (GV). This study aimed to analyze the clinical findings and virology of the two diseases. The study enrolled patients diagnosed with EV and GV by clinical and histopathological findings. Read More

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September 2021

Mixed Bacteriophage MS2-L2 VLPs Elicit Long-Lasting Protective Antibodies against HPV Pseudovirus 51.

Viruses 2021 06 10;13(6). Epub 2021 Jun 10.

Department of Biological Sciences, Michigan Technological University, Houghton, MI 49931, USA.

Three prophylactic vaccines are approved to protect against HPV infections. These vaccines are highly immunogenic. The most recent HPV vaccine, Gardasil-9, protects against HPV types associated with ~90% of cervical cancer (worldwide). Read More

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ALA-PDT successfully treated multiple cSCC in situ and AK in a patient with Epidermodysplasia verruciformis.

Photodiagnosis Photodyn Ther 2021 Sep 11;35:102395. Epub 2021 Jun 11.

Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China. Electronic address:

5-aminolaevulinic acid photodynamic therapy (ALA-PDT) has emerged as a non-invasive treatment modality for premalignant and malignant skin lesions. It has the advantage of better tolerance and providing better cosmetic outcomes than conventional treatment methods. Herein, we report a patient who suffered from multiple cutaneous squamous cell carcinoma (cSCC) in situ and actinic keratosis (AK) scattered in the body's sun-exposed areas, which had led him to undergo multiple surgical resections since the age of 16. Read More

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September 2021

Successful treatment of upper-left eyelid squamous cell carcinoma in an epidermodysplasia verruciformis patient by ALA-PDT/holmium laser combination therapy.

Photodiagnosis Photodyn Ther 2021 Jun 2;34:102277. Epub 2021 Apr 2.

Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address:

Epidermodysplasia verruciformis (EV) is a rare autosomal recessive disorder. Individuals with EV are more susceptible to the development of cutaneous neoplasia in sun-exposed regions. This disease should be closely observed for cutaneous squamous cell carcinoma (cSCC) or pre-cancerous lesions - if neoplasia is found, it should be removed. Read More

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