821 results match your criteria Epidermodysplasia Verruciformis


Multiple flat-topped scaly violaceous papules.

Dermatol Online J 2019 Mar 15;25(3). Epub 2019 Mar 15.

Texas A & M University College of Medicine, College Station, Texas.

Epidermodysplasia verruciformis (EV) is an autosomal recessive genodermatosis characterized by susceptibility to beta-genus human papillomavirus (HPV) infection. Owing to TMC6/EVER1 and TMC8/EVER2 mutations that lead to abnormal transmembrane channels in the endoplasmic reticulum involved in immunological pathways, keratinocytes cannot combat infection from non-pathogenic HPV strains. Mutations involving RHOH, MST-1, CORO1A, and IL-7 have also been associated with EV in patients without TMC6 or TMC8 mutations. Read More

View Article

Download full-text PDF

Source
March 2019
2 Reads

Cross-talk of cutaneous beta human papillomaviruses and the immune system: determinants of disease penetrance.

Philos Trans R Soc Lond B Biol Sci 2019 May;374(1773):20180287

2 Institute of Virology, Saarland University Medical Center , Kirrbergerstr. Building 47, 66421 Homburg/Saar , Germany.

Human papillomaviruses (HPVs) infect the epithelia of skin or mucosa, where they can induce hyperproliferative lesions. More than 220 different HPV types have been characterized and classified into five different genera. Mucosal high-risk HPVs are causative for cancers of the anogenital region and oropharynx. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1098/rstb.2018.0287DOI Listing
May 2019
1 Read

The Protein Tyrosine Phosphatase H1 PTPH1 Supports Proliferation of Keratinocytes and is a Target of the Human Papillomavirus Type 8 E6 Oncogene.

Cells 2019 Mar 14;8(3). Epub 2019 Mar 14.

Institute of Virology, University of Cologne, Faculty of Medicine and University Hospital of Cologne,Fürst-Pückler-Strasse 56, 50935 Cologne, Germany.

Human papillomaviruses (HPV) replicate their DNA in the suprabasal layer of the infected mucosa or skin. In order to create a suitable environment for vegetative viral DNA replication HPV delay differentiation and sustain keratinocyte proliferation that can lead to hyperplasia. The mechanism underlying cell growth stimulation is not well characterized. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cells8030244DOI Listing
March 2019
1 Read

Dermoscopic and reflectance confocal microscopic features of epidermodysplasia verruciformis.

J Dermatol 2019 Feb 25. Epub 2019 Feb 25.

Department of Pathology, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1346-8138.14824DOI Listing
February 2019
3 Reads

Inherited Interleukin 2-Inducible T-Cell (ITK) Kinase Deficiency in Siblings With Epidermodysplasia Verruciformis and Hodgkin Lymphoma.

Clin Infect Dis 2019 Feb 19. Epub 2019 Feb 19.

Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College, and Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania.

Biallelic mutations in the ITK gene cause a T-cell primary immunodeficiency with Epstein-Barr virus (EBV)-lymphoproliferative disorders. We describe a novel association of a homozygous ITK mutation with β-human papillomavirus (HPV)-positive epidermodysplasia verruciformis. Thus, loss of function in ITK can result in broad dysregulation of T-cell responses to oncogenic viruses, including β-HPV and EBV. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/cid/advance-article/doi/10.1093/cid
Publisher Site
http://dx.doi.org/10.1093/cid/ciy942DOI Listing
February 2019
6 Reads
8.886 Impact Factor

Diagnosis of epidermodysplasia verruciformis: Two cases highlighting the role of direct HPV L1 gene sequencing.

J Cutan Pathol 2019 Feb 17. Epub 2019 Feb 17.

Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota.

Epidermodysplasia verruciformis (EV) is a rare skin disease characterized by the development of multiple flat warts with the potential for malignant transformation. Patients are susceptible to human papillomavirus (HPV) infection that develops in a background of either a genetic or acquired immunodeficiency predisposing patients to infection with specific HPV types that are ubiquitous but generally non-pathogenic in healthy individuals. There is no standard clinical methodology for determining the causative HPV from patients with suspected EV. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cup.13444DOI Listing
February 2019
1 Read

Epidermodysplasia verruciformis in a young adult with activated PI3Kδ syndrome.

JAAD Case Rep 2019 Feb 31;5(2):195-197. Epub 2019 Jan 31.

Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jdcr.2018.10.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357544PMC
February 2019

Beta Human Papillomavirus and Associated Diseases.

Acta Cytol 2019 Jan 23;63(2):100-108. Epub 2019 Jan 23.

Infections and Cancer Biology Group, International Agency for Research on Cancer, World Health Organization, Lyon, France.

The cutaneous human papillomavirus (HPV), mostly from β- and γ-HPV genus, is ubiquitously distributed throughout the human body and may be part of the commensal flora. The association of β-HPVs and cutaneous squamous cell carcinoma (cSCC) development was initially reported in patients with the rare genetic disorder Epidermodysplasia verruciformis. Likewise, immunosuppressed organ transplant recipients have an increased susceptibility to β-HPV infections in the skin as well as to cSCC development. Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/492659
Publisher Site
http://dx.doi.org/10.1159/000492659DOI Listing
January 2019
4 Reads

Skin Cancer Associated Genodermatoses: A Literature Review.

Acta Derm Venereol 2019 Apr;99(4):360-369

Department of Dermatology and Allergy Centre, Odense University Hospital, DK-5000 Odense, Denmark.

Skin cancer has become the most common type of cancer worldwide as a result of environmental exposure and medical treatments. A small group of patients are genetically predisposed to skin cancer and this article is intended as a diagnostic tool when encountering patients with multiple skin cancer lesions. The disorders are described with clinical characteristics, genetics and management. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2340/00015555-3123DOI Listing
April 2019
12 Reads

A Novel STK4 Mutation Presenting with Juvenile Idiopathic Arthritis and Epidermodysplasia Verruciformis.

J Clin Immunol 2019 Jan 5;39(1):11-14. Epub 2019 Jan 5.

Division of Allergy and Clinical Immunology, Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s10875-018-0586-8
Publisher Site
http://dx.doi.org/10.1007/s10875-018-0586-8DOI Listing
January 2019
5 Reads

Metagenomic Discovery of 83 New Human Papillomavirus Types in Patients with Immunodeficiency.

mSphere 2018 12 12;3(6). Epub 2018 Dec 12.

Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, Maryland, USA.

Several immunodeficiencies are associated with high susceptibility to persistent and progressive human papillomavirus (HPV) infection leading to a wide range of cutaneous and mucosal lesions. However, the HPV types most commonly associated with such clinical manifestations in these patients have not been systematically defined. Here, we used virion enrichment, rolling circle amplification, and deep sequencing to identify circular DNA viruses present in skin swabs and/or wart biopsy samples from 48 patients with rare genetic immunodeficiencies, including patients with warts, hypogammaglobulinemia, infections, myelokathexis (WHIM) syndrome, or epidermodysplasia verruciformis (EV). Read More

View Article

Download full-text PDF

Source
http://msphere.asm.org/lookup/doi/10.1128/mSphereDirect.0064
Publisher Site
http://dx.doi.org/10.1128/mSphereDirect.00645-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291628PMC
December 2018
25 Reads

A CIB1 Splice-Site Founder Mutation in Families with Typical Epidermodysplasia Verruciformis.

J Invest Dermatol 2018 Nov 29. Epub 2018 Nov 29.

Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College, and Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0022202X183289
Publisher Site
http://dx.doi.org/10.1016/j.jid.2018.11.011DOI Listing
November 2018
18 Reads
7.216 Impact Factor

[Epidermodysplasia verruciformis: about a case].

Pan Afr Med J 2018 29;30:78. Epub 2018 May 29.

Hôpital Civil Tétouan, Tétouan, Maroc.

Epidermodysplasia verruciformis, also known as Lewandowsky-Lutz syndrome or tree man disease is a rare genetic skin disorder. It is characterized by abnormal susceptibility of the skin coating to human papillomaviruses (HPVs). It commonly affects people between the ages of 4 and 8, most often before the age of 20 years but it may exceptionally occur later. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.11604/pamj.2018.30.78.16058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191268PMC
October 2018
6 Reads

[Low-dose prophylactic oral isotretinoin treatment for 18 years in a patient with epidermodysplasia verruciformis and numerous squamous cell carcinomas].

Hautarzt 2018 Dec;69(12):1033-1038

Klinik für Hautkrankheiten und Allergologie, HELIOS Vogtland-Klinikum Plauen GmbH, Postfach 100153, 08505, Plauen, Deutschland.

Epidermodysplasia verruciformis (also known as Lewandowsky-Lutz dysplasia) is an extremely rare autosomal recessive genodermatosis, in which the skin is unusually sensitive to human papilloma viruses (HPV). It is associated with a high risk of developing non-melanocytic skin tumors. Treatment with keratolytic retinoids is currently considered to be the most effective therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00105-018-4267-6DOI Listing
December 2018
1 Read

Acquired epidermodysplasia verruciformis in setting of tumor necrosis factor-α inhibitor therapy.

JAAD Case Rep 2018 Sep 14;4(8):805-807. Epub 2018 Sep 14.

Department of Dermatology, University of Minnesota, Minneapolis, Minnesota.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jdcr.2018.05.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141641PMC
September 2018
3 Reads

A novel approach to the classification of epidermodysplasia verruciformis.

Int J Dermatol 2018 Nov 29;57(11):1344-1350. Epub 2018 Aug 29.

Department of Dermatology, University of Texas Health Science Center at Houston, Houston, TX, USA.

Background: Epidermodysplasia verruciformis (EV) is a rare genodermatosis that causes disseminated eruptions of hypo- or hyperpigmented macules and wart-like papules that can coalesce and scale. It is uniquely characterized by an increased susceptibility to specific human papillomavirus (HPV) genotypes. Classically, EV is associated with mutations of the EVER1/TMC6 and EVER2/TMC8 genes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ijd.14196DOI Listing
November 2018
4 Reads

An nonsense somatic mutation in a female with epidermodysplasia verruciformis (Tree Man Syndrome).

Clin Case Rep 2018 Aug 5;6(8):1426-1430. Epub 2018 Jun 5.

The Centre for Applied Genomics The Hospital for Sick Children Toronto ON Canada.

Epidermodysplasia verruciformis (EV) is an extremely rare hereditary skin disease characterized by an abnormal susceptibility to the human papilloma virus (HPV) with an increased risk of cutaneous malignancy. Here we report the first female severe EV case in Bangladesh, a 10-year-old girl with a nonsense somatic mutation impacting gene. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ccr3.1595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099040PMC
August 2018
14 Reads

Epidemiology and biology of cutaneous human papillomavirus.

Clinics (Sao Paulo) 2018 08 20;73(suppl 1):e489s. Epub 2018 Aug 20.

Centro de Investigação Translacional em Oncologia, Instituto do Cancer do Estado de Sao Paulo (ICESP), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.

Cutaneous human papillomaviruses (HPVs) include β- and γ-HPVs, in addition to a small fraction of α-HPVs. β-HPVs were first isolated from patients with the rare genetic disorder Epidermodysplasia verruciformis, and they are associated with the development of nonmelanoma skin cancer at sun-exposed skin sites in these individuals. Organ transplant recipients also have greater susceptibility to β-HPV infection of the skin and an increased risk of developing nonmelanoma skin cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.6061/clinics/2018/e489sDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097087PMC
August 2018
1 Read

HPV: CIB1 is for EVER and EVER.

J Exp Med 2018 Sep 1;215(9):2229-2231. Epub 2018 Aug 1.

Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD

In this issue, de Jong et al. (https://doi.org/10. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1084/jem.20181207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122965PMC
September 2018
15 Reads

The human CIB1-EVER1-EVER2 complex governs keratinocyte-intrinsic immunity to β-papillomaviruses.

J Exp Med 2018 Sep 1;215(9):2289-2310. Epub 2018 Aug 1.

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY

Patients with epidermodysplasia verruciformis (EV) and biallelic null mutations of (encoding EVER1) or (EVER2) are selectively prone to disseminated skin lesions due to keratinocyte-tropic human β-papillomaviruses (β-HPVs), which lack E5 and E8. We describe EV patients homozygous for null mutations of the gene encoding calcium- and integrin-binding protein-1 (CIB1). CIB1 is strongly expressed in the skin and cultured keratinocytes of controls but not in those of patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1084/jem.20170308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122964PMC
September 2018
30 Reads
1 Citation
12.520 Impact Factor

Epidermodysplasia Verruciformis: Genetic Heterogeneity and EVER1 and EVER2 Mutations Revealed by Genome-Wide Analysis.

J Invest Dermatol 2019 Jan 20;139(1):241-244. Epub 2018 Jul 20.

Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College and Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0022202X183236
Publisher Site
http://dx.doi.org/10.1016/j.jid.2018.07.010DOI Listing
January 2019
17 Reads
1 Citation
7.220 Impact Factor

Malignant degeneration of diffuse intertriginous flat warts in a patient with AIDS.

JAAD Case Rep 2018 Jul 7;4(6):562-564. Epub 2018 Jun 7.

Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jdcr.2018.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041375PMC
July 2018
15 Reads

Epidermodysplasia Verruciformis: Inborn Errors of Immunity to Human Beta-Papillomaviruses.

Front Microbiol 2018 12;9:1222. Epub 2018 Jun 12.

Department of Biomedicine, University Hospital of Basel, University of Basel, Basel, Switzerland.

Epidermodysplasia verruciformis (EV) is an autosomal recessive skin disorder with a phenotype conditional on human beta-papillomavirus (beta-HPV) infection. Such infections are common and asymptomatic in the general population, but in individuals with EV, they lead to the development of plane wart-like and red or brownish papules or pityriasis versicolor-like skin lesions, from childhood onwards. Most patients develop non-melanoma skin cancer (NMSC), mostly on areas of UV-exposed skin, from the twenties or thirties onwards. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmicb.2018.01222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005841PMC
June 2018
30 Reads

Characterization of a new genotype of Betapapillomavirus HPV 17 through L1, E7, E7 and LCR sequences.

Acta Virol 2018;62(2):172-178

Human papillomavirus (HPV) exhibits epithelial and mucosal tropism. HPV type 17 belongs to the Betapapillomavirus genus and molecular cloning experiments have identified two subtypes (17a and 17b) isolated from epidermodysplasia verruciformis (EV). HPV subtypes are characterized by dissimilarities from 2 to 10% at the nucleotide level from their referenced HPV. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4149/av_2018_208DOI Listing
December 2018
1 Read

Inhibition of TGF-β and NOTCH Signaling by Cutaneous Papillomaviruses.

Front Microbiol 2018 8;9:389. Epub 2018 Mar 8.

Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA, United States.

Infections with cutaneous papillomaviruses have been linked to cutaneous squamous cell carcinomas that arise in patients who suffer from a rare genetic disorder, epidermodysplasia verruciformis, or those who have experienced long-term, systemic immunosuppression following organ transplantation. The E6 proteins of the prototypical cutaneous human papillomavirus (HPV) 5 and HPV8 inhibit TGF-β and NOTCH signaling. The papillomavirus 1, MmuPV1, infects laboratory mouse strains and causes cutaneous skin warts that can progress to squamous cell carcinomas. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmicb.2018.00389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852067PMC
March 2018
3 Reads

Chronic Inflammatory Microenvironment in Epidermodysplasia Verruciformis Skin Lesions: Role of the Synergism Between HPV8 E2 and C/EBPβ to Induce Pro-Inflammatory S100A8/A9 Proteins.

Front Microbiol 2018 7;9:392. Epub 2018 Mar 7.

Institute of Virology, Saarland University Medical Center, Homburg, Germany.

Persistent genus β-HPV (human papillomavirus) infection is a major co-factor for non-melanoma skin cancer in patients suffering from the inherited skin disease epidermodysplasia verruciformis (EV). Malignant EV lesions are particularly associated with HPV type 5 or 8. There is clinical and molecular evidence that HPV8 actively suppresses epithelial immunosurveillance by interfering with the recruitment of Langerhans cells, which may favor viral persistence. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmicb.2018.00392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845987PMC
March 2018
44 Reads
3.941 Impact Factor

Identification and characterization of two novel Gammapapillomavirus genomes in skin of an immunosuppressed Epidermodysplasia Verruciformis patient.

Virus Res 2018 04 8;249:66-68. Epub 2018 Mar 8.

Infections and Cancer Biology Group, International Agency for Research on Cancer, Lyon, France. Electronic address:

Two novel human gamma-papillomavirus genomes (HPV_MTS3, and HPV_MTS4) were isolated from the skin of an immunosuppressed, late-onset Epidermodysplasia Verruciformis patient and fully cloned. The L1 open reading frames of HPV_MTS3 and HPV_MTS4 were 77% and 91% identical to their closest HPV full genome isolates w18c39 and EV03c60, which belong to the species gamma-22and gamma-7 of the genus Gammapapillomavirus, respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.virusres.2018.03.003DOI Listing
April 2018
15 Reads

Cutaneous squamous cell carcinoma with epidermodysplasia verruciformis-like features in a patient with Schimke immune-osseous dysplasia.

J Cutan Pathol 2018 06 3;45(6):465-467. Epub 2018 Apr 3.

Department of Dermatology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/cup.13139
Publisher Site
http://dx.doi.org/10.1111/cup.13139DOI Listing
June 2018
12 Reads

Zinc and Skin Disorders.

Nutrients 2018 Feb 11;10(2). Epub 2018 Feb 11.

Department of Dermatology, Faculty of Medicine, University of Yamanashi, Yamanashi 409-3898, Japan.

The skin is the third most zinc (Zn)-abundant tissue in the body. The skin consists of the epidermis, dermis, and subcutaneous tissue, and each fraction is composed of various types of cells. Firstly, we review the physiological functions of Zn and Zn transporters in these cells. Read More

View Article

Download full-text PDF

Source
http://www.mdpi.com/2072-6643/10/2/199
Publisher Site
http://dx.doi.org/10.3390/nu10020199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852775PMC
February 2018
9 Reads

[Cutaneous infections: Pathologist's role in unusual or atypical situations].

Ann Pathol 2018 Feb 26;38(1):20-30. Epub 2017 Dec 26.

Département de pathologie, groupe hospitalier Henri-Mondor, AP-HP, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil, France. Electronic address:

In infectious pathology, the gold standard consists of the detection of the pathogen within the sample. Identification of the pathogen is often difficult despite the presence of few and inexpensive tools, such, as special stain, immunohistochemistry, or in situ hybridization specific of the pathogen. In infectious pathology, there are morphological signs, which can guide us towards an etiology. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.annpat.2017.10.016DOI Listing
February 2018

Epidermodysplasia verruciformis in an adult patient with a germline Interleukin-2 inducible T-Cell Kinase mutation and lymphoma: the case of inherited versus acquired.

J Eur Acad Dermatol Venereol 2018 Jun 8;32(6):e240-e241. Epub 2018 Jan 8.

Dermatology Department, Hôpital Saint Louis, 1 avenue Claude Vellefaux, 75010, Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jdv.14756DOI Listing
June 2018
6 Reads

Loss of Genome Fidelity: Beta HPVs and the DNA Damage Response.

Front Microbiol 2017 15;8:2250. Epub 2017 Nov 15.

Division of Biology, Kansas State University, Manhattan, KS, United States.

While the role of genus alpha human papillomaviruses in the tumorigenesis and tumor maintenance of anogenital and oropharyngeal cancers is well-established, the role of genus beta human papilloviruses (β-HPVs) in non-melanoma skin cancers (NMSCs) is less certain. Persistent β-HPV infections cause NMSCs in sun-exposed skin of people with a rare genetic disorder, epidermodysplasia verruciformis. However, β-HPV infections in people without epidermodysplasia verruciformis are typically transient. Read More

View Article

Download full-text PDF

Source
http://journal.frontiersin.org/article/10.3389/fmicb.2017.02
Publisher Site
http://dx.doi.org/10.3389/fmicb.2017.02250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5694782PMC
November 2017
4 Reads

HPV8-E6 Interferes with Syntenin-2 Expression through Deregulation of Differentiation, Methylation and Phosphatidylinositide-Kinase Dependent Mechanisms.

Front Microbiol 2017 8;8:1724. Epub 2017 Sep 8.

Institute of Virology, University of CologneCologne, Germany.

The E6 oncoproteins of high-risk human papillomaviruses (HPV) of genus alpha contain a short peptide sequence at the carboxy-terminus, the PDZ binding domain, with which they interact with the corresponding PDZ domain of cellular proteins. Interestingly, E6 proteins from papillomaviruses of genus beta (betaPV) do not encode a comparable PDZ binding domain. Irrespective of this fact, we previously showed that the E6 protein of HPV8 (betaPV type) could circumvent this deficit by targeting the PDZ protein Syntenin-2 through transcriptional repression (Lazic et al. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmicb.2017.01724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609557PMC
September 2017
9 Reads

Epidermodysplasia verruciformis: three case reports and a brief review.

Acta Dermatovenerol Alp Pannonica Adriat 2017 09;26(3):59-61

Department of Dermatology, Safdarjung Hospital, New Delhi, India.

Epidermodyplasia verruciformis (EV) is a rare heritable disease that is characterized by an increased susceptibility to infection with specific human papillomavirus (HPV) types due to a defect in cell-mediated immune response to HPV infection. Widespread infection with HPV is responsible for the development of wart-like lesions and pityriasis versicolor-like spots. These individuals have a lifelong risk of developing cutaneous malignancies, especially Bowen's disease and squamous cell carcinoma, mainly in sun-exposed parts. Read More

View Article

Download full-text PDF

Source
September 2017
3 Reads

Immunopathogenesis of HPV-Associated Cancers and Prospects for Immunotherapy.

Authors:
Sigrun Smola

Viruses 2017 09 12;9(9). Epub 2017 Sep 12.

Institute of Virology, Saarland University Medical Center, 66421 Homburg/Saar, Germany.

Human papillomavirus (HPV) infection is a causative factor for various cancers of the anogenital region and oropharynx, and is supposed to play an important cofactor role for skin carcinogenesis. Evasion from immunosurveillance favors viral persistence. However, there is evidence that the mere presence of oncogenic HPV is not sufficient for malignant progression and that additional tumor-promoting steps are required. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/v9090254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618020PMC
September 2017
4 Reads

Case of diffuse panbronchiolitis developed in a patient with epidermodysplasia verruciformis.

J Dermatol 2017 Dec 24;44(12):e363-e364. Epub 2017 Aug 24.

Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1346-8138.14007DOI Listing
December 2017
18 Reads

Combined immunodeficiency with EBV positive B cell lymphoma and epidermodysplasia verruciformis due to a novel homozygous mutation in RASGRP1.

Clin Immunol 2017 10 16;183:142-144. Epub 2017 Aug 16.

Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States. Electronic address:

RASGRP1 is a guanine-nucleotide-exchange factor essential for MAP-kinase mediated signaling in lymphocytes. We report the second case of RASGRP1 deficiency in a patient with a homozygous nonsense mutation in the catalytic domain of the protein. The patient had epidermodysplasia verruciformis, suggesting a clinically important intrinsic T cell function defect. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clim.2017.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673555PMC
October 2017
28 Reads

Benign and malignant hybrid adnexal tumors in a patient with epidermodysplasia verruciformis.

J Cutan Pathol 2017 Nov 4;44(11):969-973. Epub 2017 Sep 4.

Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts.

Epidermodysplasia verruciformis (EV) is a genodermatosis characterized by overgrowth of flat warts, pityriasis versicolor-like lesions and an increased propensity for developing cutaneous squamous cell carcinomas due to abnormal susceptibility to infection with beta-human papilloma viruses. Adnexal tumors are not typically associated with EV. Here we report a spectrum of hybrid adnexal tumors with divergent eccrine and folliculosebaceous differentiation, and cytologic features ranging from benign to frankly atypical, in a patient with inherited EV. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cup.13022DOI Listing
November 2017
5 Reads

Plasmacytoid dendritic cells and type I interferon in the immunological response against warts.

Clin Exp Dermatol 2017 Dec 24;42(8):857-862. Epub 2017 Jul 24.

Dermatology Department, American University of Beirut Medical Center, Beirut, Lebanon.

Background: Plasmacytoid dendritic cells (pDCs) are the most potent producers of type I interferons (IFNs), and are involved in the pathogenesis of several cutaneous infectious (especially viral), inflammatory/autoimmune and neoplastic entities. Their role in the pathogenesis and regression of human papilloma virus (HPV)-induced skin lesions has not been well studied.

Aim: To investigate pDC occurrence and activity in HPV-induced skin lesions, including inflamed and uninflamed warts as well as epidermodysplasia verruciformis (EDV)-associated lesions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ced.13187DOI Listing
December 2017
3 Reads

A case of acquired epidermodysplasia verruciformis in a renal transplant recipient clearing with multimodal treatment including HPV (Gardasil) vaccination.

Australas J Dermatol 2018 May 17;59(2):147-148. Epub 2017 Jul 17.

Skin and Cancer Foundation Inc., Melbourne, Victoria, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ajd.12684DOI Listing
May 2018
8 Reads

Epidermodysplasia Verruciformis-like HPV Infection of the Vulva in Immunosuppressed Women.

Int J Gynecol Pathol 2018 May;37(3):233-238

Departments of Obstetrics and Gynecology and Pathology, Bangkok Hospital, Bangkok, Thailand (N.P.) Department of Obstetrics and Gynecology, Division of Gynecologic Oncology (S.F.) Division of Dermatopathology (S.R.G., A.C.L.) Department of Pathology, Division of Women's and Perinatal Pathology, Brigham and Women's Hospital, Boston, MA (C.P.C.) Laboratory of Experimental Pathology, GIGA-Cancer, Liege, Belgium (M.H.).

The vast majority of vulvar human papilloma virus infections are produced by α human papilloma viruses and consist of exophytic or flat warts and classic or "usual" vulvar intraepithelial neoplasia. This report details 2 examples of epidermodysplasia verruciformis-like lesions of the vulva in women who were immunosuppressed. The most consistent morphologic feature was the presence of abnormal mature keratinocytes with large pale open nuclei with small nucleoli and eosinophilic cytoplasm, situated in the upper epithelial layers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PGP.0000000000000417DOI Listing
May 2018
14 Reads
1.630 Impact Factor

Acquired Epidermodysplasia Verruciformis and Its Relationship to Immunosuppressive Therapy: Report of a Case and Review of the Literature.

J Drugs Dermatol 2017 Jul;16(7):701-704

Introduction: Epidermodysplasia verruciformis (EV) is a rare inherited dermatosis characterized by increased susceptibility to human papilloma virus infection. Acquired EV occurs in patients with compromised cell-mediated immunity, such as patients with HIV and transplant recipients. Optimal management of acquired EV has not yet been established, as cases are rare and are due to a variety of underlying conditions. Read More

View Article

Download full-text PDF

Source
July 2017
24 Reads

A novel homozygous DOCK8 mutation associated with unusual coexistence of gross molluscum contagiosum and epidermodysplasia verruciformis in a DOCK8 deficiency patient.

J Eur Acad Dermatol Venereol 2017 Nov 3;31(11):e504-e505. Epub 2017 Jul 3.

Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jdv.14344DOI Listing
November 2017
4 Reads

Novel TMC8 splice site mutation in epidermodysplasia verruciformis and review of HPV infections in patients with the disease.

J Eur Acad Dermatol Venereol 2017 Oct 4;31(10):1722-1726. Epub 2017 Aug 4.

Department of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland.

Background: Epidermodysplasia verruciformis (EV) is a genodermatosis leading to infections with cutaneous HPV, persistent plane warts and a high rate of non-melanoma skin cancer (NMSC). Biallelic loss-of-function mutations in TMC6 and TMC8 are known to be causative.

Objective: The aim of this study was to report EV-causing mutations in four patients with EV and to give an overview of all described patients with EV. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jdv.14431DOI Listing
October 2017
4 Reads

Identification of C/EBPα as a novel target of the HPV8 E6 protein regulating miR-203 in human keratinocytes.

PLoS Pathog 2017 Jun 22;13(6):e1006406. Epub 2017 Jun 22.

Institute of Virology, Saarland University, Homburg/Saar, Germany.

Patients suffering from Epidermodysplasia verruciformis (EV), a rare inherited skin disease, display a particular susceptibility to persistent infection with cutaneous genus beta-human papillomavirus (beta-HPV), such as HPV type 8. They have a high risk to develop non-melanoma skin cancer at sun-exposed sites. In various models evidence is emerging that cutaneous HPV E6 proteins disturb epidermal homeostasis and support carcinogenesis, however, the underlying mechanisms are not fully understood as yet. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1006406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481020PMC
June 2017
49 Reads

Acquired epidermodysplasia verruciformis occurring in a renal transplant recipient.

Cutis 2017 May;99(5):E9-E12

Department of Dermatology, Geisinger Medical Center, Danville, Pennsylvania, USA.

Acquired epidermodysplasia verruciformis (EDV) is a rare condition occurring in patients with depressed cellular immunity, particularly individuals with human immunodeficiency virus (HIV). Acquired EDV is less commonly reported in recipients of stem cell or solid organ transplantation. This condition typically manifests within 5 years of initial immunosuppression and can present as multiple hypopigmented to red, tinea versicolor-like macules or as multiple verrucous, flat-topped papules distributed over the trunk, arms, and legs. Read More

View Article

Download full-text PDF

Source
May 2017
43 Reads

A misdiagnosed infection mimicking "tree man disease".

PLoS Negl Trop Dis 2017 06 15;11(6):e0005543. Epub 2017 Jun 15.

Department of Dermatology, Hospital Raja Perempuan Zainab II, Kota Bharu, Kelantan, Malaysia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pntd.0005543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472256PMC
June 2017
7 Reads

HPV8 Field Cancerization in a Transgenic Mouse Model Is due to Lrig1+ Keratinocyte Stem Cell Expansion.

J Invest Dermatol 2017 10 6;137(10):2208-2216. Epub 2017 Jun 6.

European Cancer Stem Cell Research Institute, School of Biosciences, Cardiff University, Cardiff, UK. Electronic address:

β-Human papillomaviruses (HPVs) cause near ubiquitous latent skin infection within long-lived hair follicle (HF) keratinocyte stem cells. In patients with epidermodysplasia verruciformis, β-HPV viral replication is associated with skin keratosis and cutaneous squamous cell carcinoma. To determine the role of HF keratinocyte stem cells in β-HPV-induced skin carcinogenesis, we utilized a transgenic mouse model in which the keratin 14 promoter drives expression of the entire HPV8 early region (HPV8tg). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jid.2017.04.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613749PMC
October 2017
64 Reads