866 results match your criteria Epidermodysplasia Verruciformis


ALA-PDT successfully treated multiple cSCC in situ and AK in a patient with Epidermodysplasia verruciformis.

Photodiagnosis Photodyn Ther 2021 Jun 11:102395. Epub 2021 Jun 11.

Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address:

5-aminolaevulinic acid photodynamic therapy (ALA-PDT) has emerged as a non-invasive treatment modality for premalignant and malignant skin lesions. It has the advantage of better tolerance and providing better cosmetic outcomes than conventional treatment methods. Herein, we report a patient who suffered from multiple cutaneous squamous cell carcinoma (cSCC) in situ and actinic keratosis (AK) scattered in the body's sun-exposed areas, which had led him to undergo multiple surgical resections since the age of 16. Read More

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Successful treatment of upper-left eyelid squamous cell carcinoma in an epidermodysplasia verruciformis patient by ALA-PDT/holmium laser combination therapy.

Photodiagnosis Photodyn Ther 2021 Apr 2;34:102277. Epub 2021 Apr 2.

Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address:

Epidermodysplasia verruciformis (EV) is a rare autosomal recessive disorder. Individuals with EV are more susceptible to the development of cutaneous neoplasia in sun-exposed regions. This disease should be closely observed for cutaneous squamous cell carcinoma (cSCC) or pre-cancerous lesions - if neoplasia is found, it should be removed. Read More

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Epidermodysplasia verruciformis: report of two patients with autosomal dominant inheritance.

Dermatol Online J 2021 Feb 15;27(2). Epub 2021 Feb 15.

Department of Dermatology, University of São Paulo Medical School, São Paulo/SP.

Epidermodysplasia verruciformis is a rare genodermatosis associated with mutations in the EVER1/TMC6 and EVER2/TMC8 genes. The inheritance is considered to be autosomal recessive, but reports suggesting an autosomal dominant inheritance indicate disease genetic heterogeneity. Its onset occurs in early childhood and presents as a combination of pityriasis versicolor-like, flat wart-like and seborrheic keratosis-like lesions, with a potential for malignant transformation, mainly squamous cell carcinoma. Read More

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February 2021

Utility of the Human Papillomavirus Vaccination in Management of HPV-associated Cutaneous Lesions.

Skin Therapy Lett 2021 Mar;26(2):6-8

Virginia Tech Carilion School of Medicine; Roanoke, VA, USA.

Human papillomavirus (HPV)-induced cutaneous disease is a common complaint for patients presenting for dermatology evaluation. Infection by HPV is the major etiologic factor in the development of cutaneous warts, epidermodysplasia verruciformis, and possibly a subset of cutaneous squamous cell carcinoma. Carcinoma of the genitourinary tract, most notably cervical carcinoma, is the most severe manifestation of infection with specific serotypes of HPV. Read More

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Epidermodysplasia Verruciformis After Hematopoietic Stem Cell Transplantation in a Patient With Severe Combined Immunodeficiency Syndrome.

Am J Dermatopathol 2021 May;43(5):e65-e67

Pathology, Hacettepe University, School of Medicine, Ankara, Turkey.

Abstract: Epidermodysplasia verruciformis (EV) is a rare dermatologic disorder that is characterized by skin-colored-to-light brown flat, discrete or confluent papules resembling verruca plana. EV is divided into 2 forms: a classical genetic form and an acquired form. Classical genetic EV is caused by mutations in EVER1 and EVER2 genes. Read More

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One patient, two rare diseases: coexistence of epidermodysplasia verruciformis and Merkel cell carcinoma.

Pol Arch Intern Med 2021 03 11;131(3):295-296. Epub 2021 Feb 11.

Department of Dermatology, Jagiellonian University Medical College, Kraków, Poland

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Acquired epidermodysplasia verruciformis in renal-transplant recipients.

Clin Case Rep 2020 Dec 20;8(12):2678-2681. Epub 2020 Aug 20.

Department of Dermatology Charles Nicolle Hospital Tunis Tunisia.

Acquired epidermodysplasia verruciformis in renal-transplant recipients is associated with a high risk for developing squamous cell carcinoma. An accurate diagnosis and a regular monitoring in this high-risk population must be stressed. Read More

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December 2020

Cervical dysplasia in a patient with inherited epidermodysplasia verruciformis-A mere coincidence?

J Cutan Pathol 2021 Jun 22;48(6):763-770. Epub 2020 Dec 22.

Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.

Epidermodysplasia verruciformis (EV) is a rare inherited or acquired genodermatosis caused by increased susceptibility to infection by the beta subtypes of human papillomavirus (HPV). The co-occurrence of EV with high-risk (HR) HPV infection leading to cervical dysplasia is unreported in the literature to date. We report a patient with inherited EV who developed extensive anogenital and cervical dysplasia linked to concurrent HR-HPV infection. Read More

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Next-Generation Sequencing Identifies a Homozygous Nonsense p.Tyr370* Mutation of the TMC6 Gene in a Mexican Pedigree with Epidermodysplasia Verruciformis.

Rev Invest Clin 2020 Dec 1. Epub 2020 Dec 1.

Department of Genetics-Research Unit, Institute of Ophthalmology "Conde de Valenciana", Mexico City; Department of Biochemistry, Faculty of Medicine, UNAM, Mexico City, Mexico.

Epidermodysplasia verruciformis (EV) is a rare genodermatosis characterized by abnormal susceptibility to infection with b-genotype human papillomavirus (HPV) and a particular propensity to develop cutaneous malignancies. Clinical manifestations include flat, scaly, reddish hypo- and hyperpigmented macules, verruca-like papillomatous lesions, seborrheic keratosis- like lesions, and pink-red pityriasis versicolor-like lesions. Read More

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December 2020

Epidermodysplasia verruciformis with plane warts over lower abdomen and genitals.

Indian J Sex Transm Dis AIDS 2020 Jan-Jun;41(1):105-107. Epub 2020 Jun 18.

Department of Dermatology and Venereology, Pramukshwami Medical College, Karamsad, Gujarat, India.

Epidermodysplasia verruciformis (EDV) may clinically vary from pityriasis versicolor-like macules to wart-like flat papules, psoriasiform red papules, or pigmented keratotic lesions resembling seborrheic keratosis. Sun-exposed areas are commonly affected with genital areas rarely involved. It is associated with more than 30 human papillomaviruses (HPVs). Read More

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[Epidermodysplasia verruciformis].

Hautarzt 2020 Jul;71(Suppl 1):47-49

Klinik und Poliklinik für Dermatologie und Allergologie, Klinikum der Universität München, LMU München, Frauenlobstr. 9-11, 80337, München, Deutschland.

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Human Papillomavirus (HPV)-Associated Squamous Cell Carcinoma In situ With Positive p16 and Ki-67 Immunohistochemical Stains in a Young Immunocompetent Patient.

Cureus 2020 Aug 11;12(8):e9673. Epub 2020 Aug 11.

Dermatology, Honor Health/Affiliated Dermatology, Scottsdale, USA.

There is an oncogenic role of human papillomavirus (HPV) in the development of premalignant and malignant skin cancers, especially squamous cell carcinomas (SCCs). Some of the major risk factors for SCC include older age, fair skin types, immunosuppression, ultraviolet radiation (UVR), history of epidermodysplasia verruciformis (EV), and co-carcinogenesis by the HPV. Our case report exemplifies a unique case of a low-risk, 34-year-old female who developed an HPV-associated squamous cell carcinoma in situ (SCCIS) on her left palmar hand, despite having none of the contributing risk factors. Read More

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Human Papillomaviruses and Skin Cancer.

Authors:
Sigrun Smola

Adv Exp Med Biol 2020 ;1268:195-209

Institute of Virology Saarland University Medical Center, Homburg/Saar, Germany.

Human papillomaviruses (HPVs) infect squamous epithelia and can induce hyperproliferative lesions. More than 220 different HPV types have been characterized and classified into five different genera. While mucosal high-risk HPVs have a well-established causal role in anogenital carcinogenesis, the biology of cutaneous HPVs is less well understood. Read More

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September 2020

Gene expression is stable in a complete CIB1 knockout keratinocyte model.

Sci Rep 2020 09 11;10(1):14952. Epub 2020 Sep 11.

Department of Biomedicine, University of Basel and University Hospital Basel, Basel, Switzerland.

Epidermodysplasia verruciformis (EV) is a genodermatosis characterized by the inability of keratinocytes to control cutaneous β-HPV infection and a high risk for non-melanoma skin cancer (NMSC). Bi-allelic loss of function variants in TMC6, TMC8, and CIB1 predispose to EV. The correlation between these proteins and β-HPV infection is unclear. Read More

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September 2020

Expression of a TMC6-TMC8-CIB1 heterotrimeric complex in lymphocytes is regulated by each of the components.

J Biol Chem 2020 11 11;295(47):16086-16099. Epub 2020 Sep 11.

Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA. Electronic address:

The genes encode a set of homologous transmembrane proteins whose functions are not well understood. Biallelic mutations in either or are detected in more than half of cases of the pre-malignant skin disease epidermodysplasia verruciformis (EV). It is controversial whether EV induced by mutations in TMC6 or TMC8 originates from keratinocyte or lymphocyte defects. Read More

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November 2020

Severe Epidermodysplasia Verruciformis.

Authors:
Wei Liu Dong-Lai Ma

Mayo Clin Proc 2020 09;95(9):2035

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, National Clinical Research Center for Skin and Immune Diseases, Beijing, China. Electronic address:

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September 2020

Epidermodysplasia Verruciformis: A Rare Case Report.

Cureus 2020 Jul 7;12(7):e9046. Epub 2020 Jul 7.

Dermatology, Derma Clinic, Riyadh, SAU.

Epidermodysplasia verruciformis (EV) is an uncommon disorder that is transmitted in an autosomal recessive manner. It is characterized by increased susceptibility to human papillomavirus (HPV) infection, which presents with hypo- or hyperpigmented macular lesions, pityriasis versicolor-like lesions, and an early tendency to transform into skin cancer. We present a case of a 36-year-old female with complaints of asymptomatic, multiform lesions over the face, neck, chest, and upper arms. Read More

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Erythematous plaques on a tattoo.

Cutis 2020 Jun;105(6):E35-E37

Division of Dermatology, University of Kansas Medical Center, Kansas City, USA.

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Acquired Human Papilloma Virus Type 6-Associated Epidermodysplasia Verruciformis in a Patient With Systemic Lupus Erythematosus.

Am J Dermatopathol 2020 Nov;42(11):e156-e158

Department of Anatomical Pathology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.

Although historically known as a genetic disorder, epidermodysplasia verruciformis (EV) might be acquired in patients with a noninherited defective cell-mediated immunity. This article reports a case of EV in a patient with systemic lupus erythematosus and a history of 3 years immunosuppressive methylprednisolone treatment. The microscopic features of the skin biopsy showed morphologic changes of the keratinocytes characteristic of human papilloma virus (HPV) infections and immunoreactivity to p16. Read More

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November 2020

The Clinical Implication of Incidental Epidermodysplasia Verruciformis.

Am J Dermatopathol 2021 Feb;43(2):156-158

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia.

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February 2021

A 23-Year Follow-Up of a Patient with Gain-of-Function IkB-Alpha Mutation and Stable Full Chimerism After Hematopoietic Stem Cell Transplantation.

J Clin Immunol 2020 08 2;40(6):927-933. Epub 2020 Jul 2.

University Department of Pediatrics, Unit of Immune and Infectious Diseases, Childrens' Hospital Bambino Gesù, Piazza S. Onofrio 4, Rome, Italy.

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Acquired Epidermodysplasia Verruciformis in the Setting of Renal Transplant.

Am J Dermatopathol 2021 Jan;43(1):71-74

Trillium Creek Dermatology and Surgery Center, Medina, OH.

Abstract: Epidermodysplasia verruciformis (EV) is a rare dermatologic condition that is clinically characterized by flat, cutaneous, verrucous papules, pityriasis versicolor-like lesions, and similar lichenoid papules. There are 2 forms of EV: a classic inherited genodermatosis and a secondary acquired form. EV predisposes individuals to infections with certain types of human papillomavirus virus and subsequently increases the risk of cutaneous squamous cell carcinoma. Read More

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January 2021

Claudin expression profile in flat wart and cutaneous squamous cell carcinoma in epidermodysplasia verruciformis.

Sci Rep 2020 06 9;10(1):9268. Epub 2020 Jun 9.

Departament of Dermatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.

Epidermodysplasia verruciformis (EV) is a genodermatosis related to human beta-papillomavirus (beta-HPV), with a high risk of cutaneous squamous cell carcinoma (cSCC). Claudins are transmembrane proteins expressed in epithelia and may be altered during carcinogenesis. For a better understanding of the role of beta-HPV in cutaneous carcinogenesis, this claudin expression study was conducted on lesions of patients with and without EV. Read More

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Visual Dermatology: Epidermodysplasia Verruciformis.

J Cutan Med Surg 2020 Jun 1:1203475420931775. Epub 2020 Jun 1.

72924 Department of Dermatology, Venereology, and Leprosy, R.G.Kar Medical College, Kolkata, West Bengal, India.

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Human genetic dissection of papillomavirus-driven diseases: new insight into their pathogenesis.

Authors:
Vivien Béziat

Hum Genet 2020 Jun 20;139(6-7):919-939. Epub 2020 May 20.

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) UMR-1163, Necker Hospital for Sick Children, Paris, EU, France.

Human papillomaviruses (HPVs) infect mucosal or cutaneous stratified epithelia. There are 5 genera and more than 200 types of HPV, each with a specific tropism and virulence. HPV infections are typically asymptomatic or result in benign tumors, which may be disseminated or persistent in rare cases, but a few oncogenic HPVs can cause cancers. Read More

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Beta human papillomaviruses infection and skin carcinogenesis.

Rev Med Virol 2020 07 30;30(4):e2104. Epub 2020 Mar 30.

Department of Neurosciences, Section of Otolaryngology, University of Padova, Padova, Italy.

During the last decade, the worldwide incidence of keratinocyte carcinomas (KC) has increased significantly. They are now the most common malignancy, representing approximately 30% of all cancers. The role of ultraviolet (UV) radiation as a major environmental risk factor for skin cancers is well recognized. Read More

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Innumerable hypopigmented skin lesions in a 12-year-old girl with congenital HIV infection.

Pediatr Dermatol 2020 Jan;37(1):e20-e22

Department of Dermatology, School of Medicine, Yale University, New Haven, CT, USA.

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January 2020

["Typical" epidermodysplasia verruciformis: Identification of a molecular complex regulating keratinocyte innate immunity].

Authors:
O Dereure

Ann Dermatol Venereol 2020 Feb 14;147(2):168-169. Epub 2020 Jan 14.

Département de dermatologie et INSERM U1058 « Pathogénèse et contrôle des infections chroniques », université de Montpellier, 80, avenue Augustin-Fliche, 34295 Montpellier cedex 5, France. Electronic address:

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February 2020