157,630 results match your criteria Epidermal Nevus Syndrome


Basic chemical peeling-superficial and medium-depth peels.

J Am Acad Dermatol 2018 Dec 11. Epub 2018 Dec 11.

Department of Dermatology, Emory University School of Medicine, Atlanta, GA.

Chemical peeling, or chemexfoliation, has been used for centuries to improve signs of ultraviolet light-induced sun damage. Over the last 30 years, the science behind chemical peeling has evolved, increasing our understanding of the role of peeling ingredients and treatment indications. The depth of peels is directly related to improved results and to the number of complications that can occur. Read More

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December 2018
2 Reads

Single cell-produced and in vitro-assembled anti-FcRH5/CD3 T-cell dependent bispecific antibodies have similar in vitro and in vivo properties.

MAbs 2018 Dec 14. Epub 2018 Dec 14.

a Genentech, Inc ., South San Francisco , CA , USA.

Bispecific antibody production using single host cells has been a new advancement in the antibody engineering field. We previously showed comparable in vitro biological activity and in vivo mouse pharmacokinetics (PK) for two novel single cell variants (v10 and v11) and one traditional dual cell in vitro-assembled anti-human epidermal growth factor receptor 2/CD3 T-cell dependent bispecific (TDB) antibodies. Here, we extended our previous work to assess single cell-produced bispecific variants of a novel TDB against FcRH5, a B-cell lineage marker expressed on multiple myeloma (MM) tumor cells. Read More

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December 2018

EGFR-Mutant Adenocarcinomas That Transform to Small-Cell Lung Cancer and Other Neuroendocrine Carcinomas: Clinical Outcomes.

J Clin Oncol 2018 Dec 14:JCO1801585. Epub 2018 Dec 14.

1 Massachusetts General Hospital, Boston, MA.

Purpose: Approximately 3% to 10% of EGFR (epidermal growth factor receptor) -mutant non-small cell lung cancers (NSCLCs) undergo transformation to small-cell lung cancer (SCLC), but their clinical course is poorly characterized.

Methods: We retrospectively identified patients with EGFR-mutant SCLC and other high-grade neuroendocrine carcinomas seen at our eight institutions. Demographics, disease features, and outcomes were analyzed. Read More

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December 2018

Cytokine, chemokine and growth factor levels in peri-implant sulcus during wound healing and osseointegration after piezosurgical versus conventional implant site preparation: Randomized, controlled, split-mouth trial.

J Periodontol 2018 Dec 14. Epub 2018 Dec 14.

Division of Oral Diseases, Department of Dental Medicine, Karolinska Institute, Stockholm, Sweden.

Aim: To evaluate the cytokine, chemokine and growth factor levels in peri-implant sulcular fluid (PISF) during healing and osseointegration at osteotomy sites prepared either with piezosurgery (PS) or drills.

Materials And Methods: Fourteen patients having contralateral partial edentulism in the posterior maxilla were enrolled and 38 osteotomies were prepared. Implants were placed with one-stage surgery. Read More

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December 2018

Cetuximab-radiotherapy combination in the management of locally advanced cutaneous squamous cell carcinoma.

J Med Imaging Radiat Oncol 2018 Dec 14. Epub 2018 Dec 14.

Division of Medical Oncology, Department of Oncology, University of Alberta, and Cross Cancer Institute, Edmonton, Alberta, Canada.

Introduction: We report the outcomes of using a combination of cetuximab with radiation therapy (Cetux-RT) to treat a selected group of patients with locally advanced (unresectable) cutaneous squamous cell carcinoma (LA-cSCC). This study presents two-year efficacy and safety data for 8 patients with LA-cSCC treated within a single institution.

Methods: Between 2014 and 2017 a total of eight patients (seven males, one female) with LA-cSCC received curative intent treatment with Cetux-RT. Read More

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December 2018

HER2 mCRC patients with exon 20 R784G substitution mutation do not respond to the cetuximab therapy.

J Cell Physiol 2018 Dec 13. Epub 2018 Dec 13.

Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

The human epidermal growth factor 2 (HER2) gene undergoes various mutations that could alter its activity or respond to the antibody therapies. Cetuximab, a known anti-EGFR monoclonal antibody (mAB), is widely administered in metastatic colorectal cancer (mCRC) cases. Here we identified mCRC patients who did not respond to cetuximab (500 mg/m , q2w) after fluoropyrimidine/oxaliplatin regimen failure. Read More

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December 2018

Anti-psoriatic effect of myeloid-derived suppressor cells on imiquimod-induced skin inflammation in mice.

Scand J Immunol 2018 Dec 13:e12742. Epub 2018 Dec 13.

Pharmicell Co, Ltd, 484, Dunchon-daero, Jungwon-gu, Seongnam, Gyeonggi-do, Korea.

Myeloid-derived suppressor cells (MDSCs) play an important role in controlling the immune response against cancer and in suppression of autoimmunity and allergic inflammation. However, the beneficial effects of MDSCs on the experimental mouse model of psoriasis have not been reported. Therefore, we investigated the anti-psoriatic effect of MDSCs on IMQ-induced skin inflammation in mice and explored the mechanisms involved. Read More

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December 2018
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Visible light accelerates the ultraviolet A-induced degradation of eumelanin and pheomelanin.

Pigment Cell Melanoma Res 2018 Nov 22. Epub 2018 Nov 22.

Department of Chemistry, Fujita Health University School of Health Sciences, Toyoake, Japan.

Exposure to excess ultraviolet (UV) A radiation induces the degradation/modification of both eumelanin and pheomelanin that may be deleterious to pigmented tissues. Although the spectral distribution of solar energy comprises nearly half of visible light (VL), few studies have been conducted to examine the role of VL in the photodegradation of both types of melanin, either VL alone or in combination with UVA. In this study, we examined the effects of physiological doses of VL (150 to 300 J cm ) alone or in combination with a physiological dose of UVA (20 J cm ) in normal human epidermal melanocytes. Read More

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November 2018

Epidermal Growth Factor-Releasing Radially Aligned Electrospun Nanofibrous Patches for the Regeneration of Chronic Tympanic Membrane Perforations.

Adv Healthc Mater 2018 Dec 12:e1801160. Epub 2018 Dec 12.

Department of Biosystems & Biomaterials Science and Engineering, Seoul National University, Seoul, 151-742, Republic of Korea.

Chronic tympanic membrane (TM) perforations can cause otorrhea. To date, various types of tissue engineering techniques have been applied for the regeneration of chronic TM perforations. However, the application of nanofibers with radially aligned nanostructures and the simultaneous release of growth factors have never been applied in the regeneration of chronic TM perforations. Read More

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December 2018

ZmHAK5 and ZmHAK1 function in K uptake and distribution in maize under low K conditions.

J Integr Plant Biol 2018 Dec 11. Epub 2018 Dec 11.

State Key Laboratory of Plant Physiology and Biochemistry (SKLPPB), College of Biological Sciences, China Agricultural University, Beijing 100193, China.

Potassium (K ) is an essential macronutrient for plant growth and development. Transporters from the KT/HAK/KUP family play crucial roles in K homeostasis and cell growth in various plant species. However, their physiological roles in maize are still unknown. Read More

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December 2018

PACAP through EGFR transactivation preserves human corneal endothelial integrity.

J Cell Biochem 2018 Dec 11. Epub 2018 Dec 11.

Department of Biomedical and Biotechnological Sciences, Section of Human Anatomy and Histology, University of Catania, Catania, Italy.

The corneal endothelium is composed of a single hexagonal-shaped cells layer adherent to the Descemet's membrane. The primary function of these cells is maintaining of tissue clarity by regulating its hydration. Trauma, aging or other pathologies cause their loss, counterbalanced by enlargement of survived cells unable to guarantee an efficient fluid pumping to and from the stroma. Read More

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December 2018
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Covalent Vs Non-Covalent inhibition: Tackling Drug Resistance in EGFR - A Thorough Dynamic Perspective.

Chem Biodivers 2018 Dec 11. Epub 2018 Dec 11.

University of KwaZulu-Natal, Westville, School of Health Sciences, School of Health Sciences, University of, Not Available, 4001, Durban, SOUTH AFRICA.

A persistent challenge in the treatment of non-small cell lung cancer (NSCLC) with EGFR is the emergence of drug-resistant caused by somatic mutations. The EGFR L858R/T790M double mutant (EGFRDM) was found to be the most alarming variant. Despite the development of a wide range of inhibitors, none of them could inhibit EGFRDM effectively. Read More

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December 2018

Unripe peach (Prunus persica) extract ameliorates damage from UV irradiation and improved collagen XVIII expression in 3D skin model.

J Cosmet Dermatol 2018 Dec 7. Epub 2018 Dec 7.

Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Introduction: Collagen type XVIII regulates cellular activities of adjacent cells at the dermal-epidermal junction (DEJ). To investigate its possible changes during aging, we compared its mRNA levels and protein localization in skin samples from female participants aged 20-70 years old. In addition, we evaluated the beneficial effects of unripe peach extracts in a 3D skin model. Read More

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December 2018

CT texture analysis of lung adenocarcinoma: can Radiomic features be surrogate biomarkers for EGFR mutation statuses.

Cancer Imaging 2018 Dec 14;18(1):52. Epub 2018 Dec 14.

Department of Radiology, Shenzhen People's Hospital, the Second Clinical Medical College, Jinan University, Shenzhen, 518020, Guangdong, China.

Objective: To investigate whether radiomic features can be surrogate biomarkers for epidermal growth factor receptor (EGFR) mutation statuses.

Materials And Methods: Two hundred ninety six consecutive patients, who underwent CT examinations before operation within 3 months and had EGFR mutations tested, were enrolled in this retrospective study. CT texture features were extracted using an open-source software with whole volume segmentation. Read More

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December 2018

Safety and efficacy of dermal fibroblast conditioned medium (DFCM) fortified collagen hydrogel as acellular 3D skin patch.

Drug Deliv Transl Res 2018 Dec 13. Epub 2018 Dec 13.

Tissue Engineering Centre, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaccob Latiff, Cheras, 56000, Kuala Lumpur, Malaysia.

Skin substitutes are one of the main treatments for skin loss, and a skin substitute that is readily available would be the best treatment option. However, most cell-based skin substitutes require long production times, and therefore, patients endure long waiting times. The proteins secreted from the cells and tissues play vital roles in promoting wound healing. Read More

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December 2018

Pushing and loss of elastic fibers are highly specific for melanoma and rare in melanocytic nevi.

Arch Dermatol Res 2018 Dec 13. Epub 2018 Dec 13.

Dermatology Department, Inselspital Bern University Hospital, University of Bern, Freiburgstrasse, 3010, Bern, Switzerland.

The histopathological differentiation of melanocytic nevi from malignant melanoma (MM) is based on well-known criteria, and is straightforward in the vast majority of cases. However, there are few cases of melanocytic lesions (ML), the diagnosis of which is very challenging or even impossible. Here we have studied several morphological characteristics with particular focus on elastic fibers (EF) to identify features, helpful for the distinction between nevi and MM. Read More

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December 2018
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mutation and DNA repair and synthesis genes in non-small-cell lung cancer.

Mol Clin Oncol 2018 Dec 1;9(6):689-696. Epub 2018 Oct 1.

Department of Medical Oncology, Santa Maria della Misericordia Hospital, AOU di Perugia, I-06129 Perugia, Italy.

The aim of the present study was to assess the expression of select DNA repair and synthesis genes in non-small-cell lung cancer (NSCLC) according to mutation status. ERCC1, TS, RRM1, and BRCA1 mRNA expression levels were assessed from either primary or metastatic tumor specimens of patients diagnosed with epidermal growth factor receptor () wild-type (WT) advanced NSCLC. Total RNA was isolated from paraffin-embedded tumor specimens using the RNeasy FFPE kit and automatically purified using a QiaCube instrument. Read More

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December 2018

Phospholipase A in skin biology: new insights from gene-manipulated mice and lipidomics.

Inflamm Regen 2018 7;38:31. Epub 2018 Dec 7.

1Laboratory of Microenvironmental and Metabolic Health Science, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655 Japan.

The skin represents one of the tissues that are most profoundly influenced by alterations in the quality of lipids (lipoquality). Lipids not only constitute cellular membranes, but also serve as bioactive lipid mediators and essential components of the skin barrier. Phospholipase A (PLA) enzymes supply fatty acids and lysophospholipids from membrane phospholipids, thereby variably affecting cutaneous homeostasis. Read More

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December 2018
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Significance of the epidermal growth factor receptor mutation status and differences among molecular subgroups in surgically resected lung microinvasive adenocarcinoma.

Oncol Lett 2018 Dec 2;16(6):7057-7067. Epub 2018 Oct 2.

The Gerontology Institute of Anhui Province, Anhui Provincial Hospital, The First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui 230001, P.R. China.

Lung microinvasive adenocarcinoma (MIA) is a newly-defined subtype of early stage non-small cell lung cancer (NSCLC). However, its epidermal growth factor receptor (EGFR) mutation status and clinical significance remain unclear. The present study aimed to determine EGFR mutation characteristics and identify their significance in patients with resected lung MIA. Read More

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December 2018

Co-expression network analysis of gene expression profiles of HER2 breast cancer-associated brain metastasis.

Oncol Lett 2018 Dec 10;16(6):7008-7019. Epub 2018 Oct 10.

Department of Breast Surgery, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430079, P.R. China.

Brain metastasis occurs in ~30% of patients with breast cancer, and patients with human epidermal growth factor receptor 2 (HER2) breast cancer have a particularly high frequency of brain metastasis. Weighted gene co-expression network analysis was conducted to identify the hub differentially expressed genes from patients with HER2 breast cancer between brain metastases and primary tumors. The potential candidate genes were investigated in another set of patient samples to confirm their relevance. Read More

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December 2018

Differential expression of PMCA2 mRNA isoforms in a cohort of Spanish patients with breast tumor types.

Oncol Lett 2018 Dec 2;16(6):6950-6959. Epub 2018 Oct 2.

Department of Basic Biomedical Sciences, Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid, Villaviciosa de Odón, Madrid 28670, Spain.

The present study examined the mRNA expression levels of different isoforms of the plasma membrane calcium ATPase 2 (PMCA2) gene generated by alternative splicing at the first intracellular loop (site A) and C-terminal region (site C) in 85 human breast cancer tumor and 69 adjacent non-tumor tissues. Associations were identified between the expression of PMCA2 splice isoforms and the following clinical variables: Estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) status, tumor size, staging and histological classification, and lymph node status. Transcripts including splice site A or splice site C were amplified by reverse transcription-quantitative polymerase chain reaction using PMCA2 isoform-specific primers. Read More

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December 2018
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Bone marrow-derived epithelial cells and hair follicle stem cells contribute to development of chronic cutaneous neoplasms.

Nat Commun 2018 Dec 13;9(1):5293. Epub 2018 Dec 13.

Department of Pathology and Cell Biology, Columbia University, New York, 10032, NY, USA.

We used allogeneic bone marrow transplantation (BMT) and a mouse multistage cutaneous carcinogenesis model to probe recruitment of bone marrow-derived epithelial cells (BMDECs) in skin tumors initiated with the carcinogen, dimethylbenz[a]anthracene (DMBA), and promoted with 12-O-tetradecanolyphorbol-13-acetate (TPA). BMDECs clustered in the lesional epithelium, expressed cytokeratins, proliferated, and stratified. We detected cytokeratin induction in plastic-adherent bone marrow cells (BMCs) cultured in the presence of filter-separated keratinocytes (KCs) and bone morphogenetic protein 5 (BMP5). Read More

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December 2018

Metastatic Bulk Independently Predicts Outcomes for EGFR Precision Targeting in Colorectal Cancer.

J Natl Compr Canc Netw 2018 Dec;16(12):1442-1450

Division of Hematology and Oncology, Department of Medicine; University of Wisconsin Carbone Cancer Center; Department of Oncology, McArdle Laboratory for Cancer Research; and Departments of Biostatistics and Medical Informatics, Statistics, and Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin.

Molecular profiles guide the clinical management of metastatic colorectal cancer (mCRC), particularly related to the use of anti-epidermal growth factor receptor (EGFR) antibodies. Tumor sidedness has also been implicated in resistance to these therapies, but has largely been studied in the first-line setting. We examined the role of tumor sidedness and disease bulk in predicting clinical outcomes to anti-EGFR therapy in the treatment-refractory setting. Read More

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December 2018

RSL Class Ⅱ Transcription Factors Guide the Nuclear Localization of RHL1 to Regulate Root Hair Development.

Plant Physiol 2018 Dec 13. Epub 2018 Dec 13.

Kyung Hee University CITY: Yongin STATE: Gyeonggi-do POSTAL_CODE: 17104 Korea (South), Republic Of

Root hairs are important for absorption of nutrients and water from the rhizosphere. The ROOT HAIR DEFECTIVE-SIX LIKE (RSL) Class Ⅱ family of transcription factors is expressed preferentially in root hairs and has a conserved role in root hair development in land plants. We functionally characterized the seven members of the RSL Class II subfamily in the rice (Oryza sativa) genome. Read More

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December 2018

Relapsed and De Novo Metastatic HER2-positive Breast Cancer Treated With Trastuzumab: Tumor Genotypes and Clinical Measures Associated With Patient Outcome.

Clin Breast Cancer 2018 Nov 5. Epub 2018 Nov 5.

Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, Thessaloniki, Greece; Aristotle University of Thessaloniki, Thessaloniki, Greece.

Background: We examined tumor genotype characteristics of human epidermal growth factor receptor 2 (HER2)-positive relapsed (R-) and de novo (dn-) metastatic breast cancer (MBC) in trastuzumab-treated patients who were previously not exposed to this agent.

Materials And Methods: We analyzed genotypes obtained upon deep sequencing from 113 HER2-positive primary tumors from 69 patients with R-MBC and 44 patients with dn-MBC.

Results: Mutations were observed in 90 (79. Read More

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November 2018

Epidermal growth factor receptor and podocin predict nephropathy progression in type 2 diabetic patients through interaction with the autophagy influencer ULK-1.

J Diabetes Complications 2018 Nov 22. Epub 2018 Nov 22.

Biochemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. Electronic address:

Aims: Diabetic nephropathy (DN) that progress to end stage renal failure is a serious health problem. Autophagy is involved in DN pathogenesis. Finding renal prognostic biomarkers can help in the future renal status prevision. Read More

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November 2018

ErbB2-driven downregulation of the transcription factor Irf6 in breast epithelial cells is required for their 3D growth.

Breast Cancer Res 2018 Dec 13;20(1):151. Epub 2018 Dec 13.

Department of Pediatrics, Dalhousie University, Halifax, NS, Canada.

Background: The ability of solid tumor cells to resist anoikis, apoptosis triggered by cell detachment from the extracellular matrix (ECM), is thought to be critical for 3D tumor growth. ErbB2/Her2 oncoprotein is often overproduced by breast tumor cells and blocks their anoikis by partially understood mechanisms. In our effort to understand them better, we observed that detachment of nonmalignant human breast epithelial cells from the ECM upregulates the transcription factor Irf6. Read More

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December 2018

Metformin regulates atrial SK2 and SK3 expression through inhibiting the PKC/ERK signaling pathway in type 2 diabetic rats.

BMC Cardiovasc Disord 2018 Dec 13;18(1):236. Epub 2018 Dec 13.

Department of Cardiology, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang, 110004, People's Republic of China.

Background: Our previous study showed that metformin regulates the mRNA and protein levels of type 2 small conductance calcium-activated potassium channel (SK2) and type 3 small conductance calcium-activated potassium channels (SK3) in atrial tissue as well as the ion current of atrial myocytes in rats with type 2 diabetes mellitus (T2DM), but the underlying signaling mechanism is unknown. This study aimed to investigate whether metformin regulates atrial SK2 and SK3 protein expression in T2DM rats though the protein kinase C (PKC)/extracellular signal-regulated kinase (ERK) signaling pathway.

Methods: A T2DM rat model was established using a high-fat and high-sugar diet combined with a low-dose intraperitoneal injection of streptozotocin (STZ). Read More

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December 2018

Identification of lipids of the stratum corneum by high performance thin layer chromatography and mass spectrometry.

Eur J Mass Spectrom (Chichester) 2018 Dec 13:1469066718815380. Epub 2018 Dec 13.

3 Pierre Fabre Dermo-cosmétique, Pharmacology Unit, Toulouse, France.

The stratum corneum, the outermost layer of the epidermis, is the most important skin barrier against exogenous physical and chemical effects, in addition to protecting against dehydration. Ceramides are integral parts of the intercellular lipid lamellae of the stratum corneum and play an important role in the barrier function of mammalian skin. Ceramides are sphingolipids consisting of sphingoid bases linked to fatty acids by an amide bond. Read More

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December 2018

Melanogenesis Inhibitors from the Rhizoma of Ligusticum Sinense in B16-F10 Melanoma Cells In Vitro and Zebrafish In Vivo.

Int J Mol Sci 2018 Dec 11;19(12). Epub 2018 Dec 11.

School of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan.

The rhizoma of , a Chinese medicinal plant, has long been used as a cosmetic for the whitening and hydrating of the skin in ancient China. In order to investigate the antimelanogenic components of the rhizoma of , we performed an antimelanogenesis assay-guided purification using semi-preparative HPLC accompanied with spectroscopic analysis to determine the active components. Based on the bioassay-guided method, 24 compounds were isolated and identified from the ethyl acetate layer of methanolic extracts of , and among these, 5-[3-(4-hydroxy-3-methoxyphenyl)allyl]ferulic acid () and -4-pentylcyclohex-3-ene-1,2-diol () were new compounds. Read More

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December 2018

Upregulation of Long Non-Coding RNA DRAIC Correlates with Adverse Features of Breast Cancer.

Noncoding RNA 2018 Dec 11;4(4). Epub 2018 Dec 11.

Department of Genetics and Cell Biology, College of Life Sciences, Nankai University, Tianjin 300071, China.

(also known as and ), is a long non-coding RNA associated with several types of cancer including prostate cancer, lung cancer, and breast cancer. Its expression is elevated in tumor tissues compared to adjacent benign tissues in breast cancer patients and is regulated by estrogen treatment in breast cancer cells. In addition, expression analysis of in more than 100 cell lines showed that expression is high in luminal and basal subtypes compared to claudin low subtype, suggesting a prognostic value of expression in breast cancer. Read More

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December 2018

Topical Application of JAK1/JAK2 Inhibitor Momelotinib Exhibits Significant Anti-Inflammatory Responses in DNCB-Induced Atopic Dermatitis Model Mice.

Int J Mol Sci 2018 Dec 10;19(12). Epub 2018 Dec 10.

Division of Dermatology, Department of Clinical Medicine, Medical College of Yanbian University, Yanji 133000, China.

Atopic dermatitis (AD) is a chronic recurrent skin disease dominated by T-helper 2 inflammation. Momelotinib (MMB) is a novel JAK1/JAK2 inhibitor suppressing the signal transduction of multiple pro-inflammatory cytokines. Recent studies indicated that JAK inhibitor could play a therapeutic role in AD disease. Read More

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December 2018
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Transporter and Lysosomal Mediated (Multi)drug Resistance to Tyrosine Kinase Inhibitors and Potential Strategies to Overcome Resistance.

Cancers (Basel) 2018 Dec 10;10(12). Epub 2018 Dec 10.

Laboratory Medical Oncology, Amsterdam UMC, VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands.

Tyrosine kinase inhibitors are a class of chemotherapeutic drugs that target specific protein kinases. These tyrosine kinase inhibitors constitute a relatively new class of drugs which target for instance Bcr-Abl, Epidermal Growth Factor Receptor (EGFR) and Vascular Endothelial Growth Factor Receptor (VEGFR). Despite some initial successes, the overall therapeutic benefit of tyrosine kinase inhibitors in the clinic has been mixed. Read More

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December 2018

Regulation of EGFR Endocytosis by CBL During Mitosis.

Cells 2018 Dec 7;7(12). Epub 2018 Dec 7.

Department of Medical Genetics and Signal Transduction Research Group, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2H7, Canada.

The overactivation of epidermal growth factor (EGF) receptor (EGFR) is implicated in various cancers. Endocytosis plays an important role in EGFR-mediated cell signaling. We previously found that EGFR endocytosis during mitosis is mediated differently from interphase. Read More

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December 2018

Reversal of resistance to chemotherapy following anti-programmed cell death-1 immunotherapy in metastatic lung adenocarcinoma: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13427

Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, Henan, China.

Rationale: For metastatic non-small cell lung cancer with no epidermal growth factor receptor mutations or anaplastic lymphoma kinase gene rearrangements, programmed cell death-1 (PD-1) blockade is preferentially recommended post first-line chemotherapy. However, still many patients do not respond to these agents. After development of resistance to PD-1 blockade, further evaluation of chemotherapy regimen will be necessary. Read More

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December 2018

Multiinstitutional prospective observational study of stereotactic radiosurgery for patients with multiple brain metastases from non-small cell lung cancer (JLGK0901 study-NSCLC).

Authors:

J Neurosurg 2018 Dec;129(Suppl1):86-94

OBJECTIVEPrevious Japanese Leksell Gamma Knife Society studies (JLGK0901) demonstrated the noninferiority of stereotactic radiosurgery (SRS) alone as the initial treatment for patients with 5-10 brain metastases (BMs) compared with those with 2-4 BMs in terms of overall survival and most secondary endpoints. The authors studied the aforementioned treatment outcomes in a subset of patients with BMs from non-small cell lung cancer (NSCLC).METHODSPatients with initially diagnosed BMs treated with SRS alone were enrolled in this prospective observational study. Read More

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December 2018
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MicroRNAs as a drug resistance mechanism to targeted therapies in EGFR-mutated NSCLC: Current implications and future directions.

Drug Resist Updat 2018 Nov 28;42:1-11. Epub 2018 Nov 28.

Department of Medical Oncology, Amsterdam University Medical Center, VU University, 1081 HV Amsterdam, the Netherlands; Cancer Pharmacology Lab, AIRC Start-Up Unit, University of Pisa and Fondazione Pisana per la Scienza, 56100 Pisa, Italy. Electronic address:

The introduction of EGFR-tyrosine kinase inhibitors (TKIs) has revolutionized the treatment and prognosis of non-small cell lung cancer (NSCLC) patients harboring epidermal growth factor receptor (EGFR) mutations. However, these patients display disease progression driven by the onset of acquired mechanisms of drug resistance that limit the efficacy of EGFR-TKI to no longer than one year. Moreover, a small fraction of EGFR-mutated NSCLC patients does not benefit from this targeted treatment due to primary (i. Read More

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November 2018

A20 and ABIN1 suppression of a keratinocyte inflammatory program with a shared single cell expression signature in diverse human rashes.

J Invest Dermatol 2018 Dec 10. Epub 2018 Dec 10.

Department of Dermatology, UCSF and Veterans Affairs Medical Center, San Francisco, California, USA. Electronic address:

Genetic variation in the NFκB inhibitors, ABIN1 and A20, increase risk for psoriasis. While critical for hematopoietic immune cell function, these genes are believed to additionally inhibit psoriasis by dampening inflammatory signaling in keratinocytes. We dissected ABIN1 and A20's regulatory role in human keratinocyte inflammation using an RNA-seq based comparative genomic approach. Read More

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December 2018

Direct visualization of single-molecule membrane protein interactions in living cells.

PLoS Biol 2018 Dec 13;16(12):e2006660. Epub 2018 Dec 13.

Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea.

Interactions between membrane proteins are poorly understood despite their importance in cell signaling and drug development. Here, we present a co-immunoimmobilization assay (Co-II) enabling the direct observation of membrane protein interactions in single living cells that overcomes the limitations of currently prevalent proximity-based indirect methods. Using Co-II, we investigated the transient homodimerizations of epidermal growth factor receptor (EGFR) and beta-2 adrenergic receptor (β2-AR) in living cells, revealing the differential regulation of these receptors' dimerizations by molecular conformations and microenvironment in a plasma membrane. Read More

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December 2018

Detection and Analysis of the Hedgehog Signaling Pathway-Related Long Non-Coding RNA (lncRNA) Expression Profiles in Keloid.

Med Sci Monit 2018 Dec 13;24:9032-9044. Epub 2018 Dec 13.

Institute of Burns, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China (mainland).

BACKGROUND Hedgehog (Hh) signaling pathway-related genes have important roles in several physiological and disease processes that involve cell proliferation. Long non-coding region RNAs (lncRNAs) have a regulatory role on gene expression. Keloid is characterized by excessive proliferation of scar tissue following trauma. Read More

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December 2018

HSP70 Inhibitors Reduce The Osteoblast Migration By Epidermal Growth Factor.

Curr Mol Med 2018 Dec 12. Epub 2018 Dec 12.

Department of Pharmacology, Gifu University Graduate School of Medicine, Gifu. Japan.

Background: We have recently reported that epidermal growth factor (EGF) induces migration of osteoblast-like MC3T3-E1 cells through the activation of p44/p42 mitogen-activated protein (MAP) kinase, p38 MAP kinase, stress-activated protein kinase/ c-Jun N-terminal kinase (SAPK/JNK) and Akt. Furthermore, we demonstrated that heat shock protein 70 (HSP70) down-regulates the transforming growth factor-β-stimulated vascular endothelial growth factor synthesis via suppression of p38 MAP kinase in osteoblast-like MC3T3-E1 cells. However, the exact role of HSP70 underlying osteoblast migration is not fully elucidated. Read More

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December 2018

Wearable All-Solid-State Potentiometric Microneedle Patch for Intradermal Potassium Detection.

Anal Chem 2018 Dec 13. Epub 2018 Dec 13.

A new analytical all-solid-state platform for intradermal potentiometric detection of potassium in interstitial fluid is presented here. Solid microneedles are modified with different coatings and polymeric membranes to prepare both the potassium-selective electrode and reference electrode needed for the potentiometric readout. These microneedle-based electrodes are then fixed in an epidermal patch suitable for insertion into the skin. Read More

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December 2018

Losartan inhibits EGFR transactivation in vascular smooth muscle cells

Turk J Med Sci 2018 12 12;48(6):1364-1371. Epub 2018 Dec 12.

Department of Biochemistry, School of Medicine, Akdeniz University, Antalya, Turkey

Background/aim: Angiotensin II (Ang II)-induced molecular signaling pathways play a significant role in the progression of cardiovascular diseases, including hypertension and atherosclerosis. In addition to the well-known effects of Ang II, it may activate epidermal growth factor receptor (EGFR) in a process known as transactivation, which contributes to vascular pathologies. The aim of this study was to determine whether losartan could reduce EGFR transactivation induced by Ang II. Read More

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December 2018

Biolistic Transformation of Cotton Zygotic Embryo Meristem.

Authors:
K Rajasekaran

Methods Mol Biol 2019 ;1902:35-45

Southern Regional Research Center, USDA-ARS, New Orleans, LA, USA.

Biolistic transformation of cotton (Gossypium hirsutum L.) meristems, isolated from mature seed, is detailed in this report. A commercially available, helium-driven biolistic device (Bio-Rad PDS1000/He ) was used to bombard gold particles coated with a marker gene (uidA or "GUS") into the shoot meristem. Read More

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January 2019

Microbiota in cancer development and treatment.

J Cancer Res Clin Oncol 2018 Dec 12. Epub 2018 Dec 12.

Department of Bioinformatics and Biotechnology, International Islamic University, Islamabad, Pakistan.

Purpose: Human microbiota comprises of a variety of organisms ranging from bacterial species to viruses, fungi, and protozoa which are present on the epidermal and mucosal barriers of the body. It plays a key role in health and survival of the host by regulation of the systemic functions. Its apparent functions in modulation of the host immune system, inducing carcinogenesis and regulation of the response to the cancer therapy through a variety of mechanisms such as bacterial dysbiosis, production of genotoxins, pathobionts, and disruption of the host metabolism are increasingly becoming evident. Read More

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December 2018

Curcumin attenuates hyperglycemia-driven EGF-induced invasive and migratory abilities of pancreatic cancer via suppression of the ERK and AKT pathways.

Oncol Rep 2018 Oct 30. Epub 2018 Oct 30.

Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi 710061, P.R. China.

The relationship between diabetes mellitus and pancreatic cancer is complex. Diabetes has been postulated to be both an independent risk factor and a consequence of pancreatic cancer. Our previous study confirmed that curcumin plays a vital role in inhibiting the epithelial-mesenchymal transition of pancreatic cancer cells. Read More

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October 2018

The application of prostate specific membrane antigen in CART‑cell therapy for treatment of prostate carcinoma (Review).

Oncol Rep 2018 Oct 1. Epub 2018 Oct 1.

Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China.

Adoptive cell transfer (ACT) is an emerging immunotherapy technique that restricts tumor growth and invasion in cancer patients. Among the different types of ACT, chimeric antigen receptor (CAR)T‑cell therapy is considered to be the most advanced and a potentially powerful technique for the treatment of cancer in clinical trials. The primary aim of CART‑cell therapy is to destroy cancer cells and therefore, it serves an important role in tumor immunotherapy. Read More

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October 2018

Correlation of IL-1 and HB-EGF with endometrial receptivity.

Exp Ther Med 2018 Dec 9;16(6):5130-5136. Epub 2018 Oct 9.

Department of Clinical Laboratory, Yantai Yuhuangding Hospital, Yantai, Shandong 264000, P.R. China.

Fluctuations of interleukin-1β (IL-1β) and heparin-binding epidermal growth factor (HB-EGF) in endometrial receptivity were detected. Seventy-two patients receiving fertilization-embryo transfer (IVF-ET) for the first time in Yantaishan Hospital from July 2015 to September 2015 due to infertility were selected. The serum and follicular fluid of patients in ovulation-promoting cycle were collected; the levels of IL-1β and HB-EGF in serum and follicular fluid were detected via enzyme-linked immunosorbent assay (ELISA), and the levels of serum estradiol (E2), progesterone (P), follicle stimulating hormone (FSH) and luteinizing hormone (LH) were detected. Read More

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December 2018

Phase Ib/II single-arm trial evaluating the combination of everolimus, lapatinib and capecitabine for the treatment of HER2-positive breast cancer with brain metastases (TRIO-US B-09).

Ther Adv Med Oncol 2018 9;10:1758835918807339. Epub 2018 Nov 9.

University of California, Los Angeles, Los Angeles, CA, USA.

Background: Improving outcomes for patients with human epidermal growth factor 2-positive (HER2+) central nervous system (CNS) metastases remains an unmet clinical need. This trial evaluated a novel combination of everolimus, lapatinib and capecitabine for this disease.

Methods: Patients with trastuzumab-pretreated, HER2+ breast cancer brain metastasis without prior therapy with a mammalian target of rapamycin (mTOR) inhibitor were eligible. Read More

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November 2018

[AN UPDATE ON DIAGNOSIS AND MANAGEMENT OF DRUG ALLERGY].

Authors:
Michiko Aihara

Arerugi 2018 ;67(10):1399-1404

Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine.

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January 2018