Diagnostics (Basel) 2020 Jul 9;10(7). Epub 2020 Jul 9.
Department of Molecular Sciences, "Iuliu Hațieganu" University of Medicine and Pharmacy Cluj, 6, Pasteur St., 400349 Cluj-Napoca, Romania.
The PI3K/AKT/mTOR signaling pathway is significantly activated in rheumatoid arthritis. In addition, somatic activating mutations of the PI3K/AKT/mTOR pathway may result in -related overgrowth spectrum diseases, including CLOVES (Congenital Lipomatous Overgrowth, Vascular malformation, Epidermal nevi, Skeletal abnormalities/Scoliosis) syndrome. We describe the case of a young female patient, with anti-citrullinated peptide antibodies-positive rheumatoid arthritis, referred for persistent finger pain and stiffness. Read More