11,435 results match your criteria Epidemiologia & Prevenzione [Journal]


Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight.

Authors:
Leanne K Küpers Claire Monnereau Gemma C Sharp Paul Yousefi Lucas A Salas Akram Ghantous Christian M Page Sarah E Reese Allen J Wilcox Darina Czamara Anne P Starling Alexei Novoloaca Samantha Lent Ritu Roy Cathrine Hoyo Carrie V Breton Catherine Allard Allan C Just Kelly M Bakulski John W Holloway Todd M Everson Cheng-Jian Xu Rae-Chi Huang Diana A van der Plaat Matthias Wielscher Simon Kebede Merid Vilhelmina Ullemar Faisal I Rezwan Jari Lahti Jenny van Dongen Sabine A S Langie Tom G Richardson Maria C Magnus Ellen A Nohr Zongli Xu Liesbeth Duijts Shanshan Zhao Weiming Zhang Michelle Plusquin Dawn L DeMeo Olivia Solomon Joosje H Heimovaara Dereje D Jima Lu Gao Mariona Bustamante Patrice Perron Robert O Wright Irva Hertz-Picciotto Hongmei Zhang Margaret R Karagas Ulrike Gehring Carmen J Marsit Lawrence J Beilin Judith M Vonk Marjo-Riitta Jarvelin Anna Bergström Anne K Örtqvist Susan Ewart Pia M Villa Sophie E Moore Gonneke Willemsen Arnout R L Standaert Siri E Håberg Thorkild I A Sørensen Jack A Taylor Katri Räikkönen Ivana V Yang Katerina Kechris Tim S Nawrot Matt J Silver Yun Yun Gong Lorenzo Richiardi Manolis Kogevinas Augusto A Litonjua Brenda Eskenazi Karen Huen Hamdi Mbarek Rachel L Maguire Terence Dwyer Martine Vrijheid Luigi Bouchard Andrea A Baccarelli Lisa A Croen Wilfried Karmaus Denise Anderson Maaike de Vries Sylvain Sebert Juha Kere Robert Karlsson Syed Hasan Arshad Esa Hämäläinen Michael N Routledge Dorret I Boomsma Andrew P Feinberg Craig J Newschaffer Eva Govarts Matthieu Moisse M Daniele Fallin Erik Melén Andrew M Prentice Eero Kajantie Catarina Almqvist Emily Oken Dana Dabelea H Marike Boezen Phillip E Melton Rosalind J Wright Gerard H Koppelman Letizia Trevisi Marie-France Hivert Jordi Sunyer Monica C Munthe-Kaas Susan K Murphy Eva Corpeleijn Joseph Wiemels Nina Holland Zdenko Herceg Elisabeth B Binder George Davey Smith Vincent W V Jaddoe Rolv T Lie Wenche Nystad Stephanie J London Debbie A Lawlor Caroline L Relton Harold Snieder Janine F Felix

Nat Commun 2019 Apr 23;10(1):1893. Epub 2019 Apr 23.

The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from -183 to 178 grams per 10% increase in methylation (P < 1.06 x 10). Read More

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http://dx.doi.org/10.1038/s41467-019-09671-3DOI Listing

Diphyllobothriidea in the north area of the Andean Patagonia: Epidemiology in urban dogs, morphometrical and molecular identification, with comments on wild carnivores.

Vet Parasitol Reg Stud Reports 2018 Dec 6;14:161-169. Epub 2018 Nov 6.

Laboratorio de Parasitología, INIBIOMA (Universidad Nacional del Comahue-CONICET), (8400) Av. Quintral 1250, San Carlos de Bariloche, Río Negro, Argentina. Electronic address:

Diphyllobothriidea are the principal agents of Diphyllobothriosis, a widespread food-borne cestodosis. Accurate identification of the species in samples is therefore crucial for diagnosis and epidemiology in wild and domestic animals, and also humans. We aim to identify at specific level the causative agent, and provide an observational, descriptive, and transversal study of the epidemiology of this zoonosis in urban dogs. Read More

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http://dx.doi.org/10.1016/j.vprsr.2018.11.001DOI Listing
December 2018

[Analysis of the evolution in the access to orphan medicines in Spain].

Gac Sanit 2019 Apr 20. Epub 2019 Apr 20.

Oblikue Consulting, S.L., Barcelona, España.

Objective: To assess the access to orphan medicines in Spain, focusing on those with an active "orphan" designation, as of 31 December 2017; and for those orphan medicines in the Spanish market, estimate the time between being assigned a National Code (NC) by the Agencia Española de Medicamentos y Productos Sanitarios (AEMPS) and being approved for launch.

Method: We used the European Commission's Public Register of orphan medicines to identify the orphan medicines authorised by the European Medicines Agency (EMA), as of 31 December 2017, while we sourced expired orphan indications from the EMA's website. Dates when NCs were assigned were sourced from the AEMPS, and commercialisation dates from Bot PLUS. Read More

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http://dx.doi.org/10.1016/j.gaceta.2019.02.008DOI Listing

Elder abuse victimization patterns: latent class analysis using perpetrators and abusive behaviours.

BMC Geriatr 2019 Apr 23;19(1):117. Epub 2019 Apr 23.

Departamento de Educação e Psicologia, Universidade de Aveiro, Aveiro, Portugal.

Background: Research on elder abuse has defined it as a multidimensional construct that encompasses a set of different abusive behaviours, victims, perpetrators and settings. The array of possible elder abuse configurations is difficult to capture. This study sought to identify victimization patterns that represent distinct elder abuse configurations based on specific abusive behaviours and on the relationship with the perpetrator; it also sought to determine the association between these latent classes with victims' characteristics. Read More

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http://dx.doi.org/10.1186/s12877-019-1111-5DOI Listing

Altered Glycemic Control Associated With Polymorphisms in the SLC22A1 (OCT1) Gene in a Mexican Population With Type 2 Diabetes Mellitus Treated With Metformin: A Cohort Study.

J Clin Pharmacol 2019 Apr 23. Epub 2019 Apr 23.

Unidad de Investigación Médica en Bioquímica, Hospital de Especialidades "Bernardo Sepúlveda," Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México.

The organic cation transporters OCT1 and OCT2 and the multidrug and toxin extrusion transporter MATE1, encoded by the SLC22A1, SLC22A2, and SLC47A1 genes, respectively, are responsible for the absorption of metformin in enterocytes, hepatocytes, and kidney cells. The aim of this study was to evaluate whether genetic variations in the SLC22A1, SLC22A2, and SLC47A1 genes could be associated with an altered response to metformin in patients with type 2 diabetes mellitus. A cohort study was conducted in 308 individuals with a diagnosis of type 2 diabetes mellitus of less than 3 years and who had metformin monotherapy. Read More

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http://dx.doi.org/10.1002/jcph.1425DOI Listing

Aging with multiple sclerosis: prevalence and profile of cognitive impairment.

Neurol Sci 2019 Apr 23. Epub 2019 Apr 23.

Department NEUROFARBA, Section Neurosciences, University of Florence, Largo Brambilla 3, 50134, Florence, Italy.

Background: The increase in life expectancy of patients with multiple sclerosis (MS) requires a better knowledge of disease features in the older patients group.

Objective: To describe the prevalence and profile of cognitive impairment (CI) in older patients with MS and perform a comparison with younger patients.

Methods: Patients were consecutively recruited for 6 months. Read More

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http://dx.doi.org/10.1007/s10072-019-03875-7DOI Listing

Socioeconomic position and exposure to multiple environmental chemical contaminants in six European mother-child cohorts.

Int J Hyg Environ Health 2019 Apr 19. Epub 2019 Apr 19.

ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Spain. Electronic address:

Background: Human exposure to environmental chemical contaminants at critical periods of development can lead to lifelong health consequences. Traditionally, socioeconomically disadvantaged groups are thought to experience higher contaminant exposures; however, this relationship may not hold for all contaminants.

Methods: Using data from six European birth cohorts (1301 mother-child pairs), we determined biomarkers of exposure to 41 contaminants in biological samples from children (6-12 years) and their mothers during pregnancy, including organochlorine compounds (OCs), polybrominated diphenyl ethers (PBDEs), per- and polyfluoroalkyl substances (PFASs), metals, phthalate metabolites, phenols, and organophosphate (OP) pesticide metabolites. Read More

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http://dx.doi.org/10.1016/j.ijheh.2019.04.002DOI Listing

First Evidence of Antibodies Against Lloviu Virus in Schreiber's Bent-Winged Insectivorous Bats Demonstrate a Wide Circulation of the Virus in Spain.

Viruses 2019 Apr 19;11(4). Epub 2019 Apr 19.

Arbovirus and Imported Viral Diseases Laboratory, National Centre of Microbiology, Majadahonda, 28220 Madrid, Spain.

Although Lloviu virus (LLOV) was discovered in the carcasses of insectivorous Schreiber's Bent-winged bats in the caves of Northern Spain in 2002, its infectivity and pathogenicity remain unclear. We examined the seroprevalence of LLOV in potentially exposed Schreiber's Bent-winged bats ( = 60), common serotine bats ( = 10) as controls, and humans ( = 22) using an immunoblot assay. We found antibodies against LLOV GP in all of Schreiber's Bent-winged bats serum pools, but not in any of the common serotine bats and human pools tested. Read More

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http://dx.doi.org/10.3390/v11040360DOI Listing

Geographic dissemination of endovascular stroke thrombectomy in Catalonia within the 2011-2015 period.

Eur Stroke J 2017 Jun 27;2(2):163-170. Epub 2017 Feb 27.

Stroke Programme, Agency for Health Quality and Assessment of Catalonia, Spain.

Introduction: Endovascular thrombectomy was recently established as a new standard of care in acute ischemic stroke patients with large artery occlusions. Using small area health statistics, we sought to assess dissemination of endovascular thrombectomy in Catalonia throughout the period 2011-2015.

Patients And Methods: We used registry data to identify all endovascular thrombectomies for acute ischemic stroke performed in Catalonia within the study period. Read More

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http://dx.doi.org/10.1177/2396987317696376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453208PMC

Influence of the Urban Exposome on Birth Weight.

Environ Health Perspect 2019 Apr;127(4):47007

4 Team of environmental epidemiology applied to reproduction and respiratory health, Institut national de la santé et de la recherche médicale (Inserm, National Institute of Health & Medical Research), Institute for Advanced Biosciences (IAB), CNRS, Université Grenoble Alpes , Grenoble, France.

Background: The exposome is defined as the totality of environmental exposures from conception onwards. It calls for providing a holistic view of environmental exposures and their effects on human health by evaluating multiple environmental exposures simultaneously during critical periods of life.

Objective: We evaluated the association of the urban exposome with birth weight. Read More

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http://dx.doi.org/10.1289/EHP3971DOI Listing

Sociodemographic factors associated with secondhand smoke exposure and smoking rules in homes with children.

Eur J Public Health 2019 Apr 22. Epub 2019 Apr 22.

Agència de Salut Pública de Barcelona, Servei d'Avaluació i Mètodes d'Intervenció, Barcelona, Spain.

Background: This study aims to identify sociodemographic characteristics associated with secondhand smoke (SHS) exposure and the adoption of smoking bans in homes with children in Spain.

Methods: We performed, in 2016, a cross-sectional study to a representative sample of Spanish households with children under 12 years old. We administered a telephone survey to the parents asking about smoking patterns at home, children's SHS exposure and sociodemographic characteristics. Read More

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https://academic.oup.com/eurpub/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/eurpub/ckz054DOI Listing
April 2019
1 Read

Influenza A H1N1 Community-Acquired Pneumonia: Characteristics and Risk Factors-A Case-Control Study.

Can Respir J 2019 17;2019:4301039. Epub 2019 Mar 17.

Service of Pneumology, University Clinical Hospital of Santiago de Compostela, Santiago de Compostela, Spain.

Introduction: Influenza A H1N1 community-acquired pneumonia (CAP) is a quite frequent respiratory disease. Despite being considered more serious than other CAPs, there are very few studies comparing its characteristics with noninfluenza CAP. We aim to establish the differences between pneumonia due to H1N1 virus and pneumonia not caused by H1N1 influenza virus and to determine the probability that a pneumonia is due to an H1N1 virus infection based on the most relevant variables. Read More

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http://dx.doi.org/10.1155/2019/4301039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441515PMC

Consumption of Meat, Fish, Dairy Products, Eggs and Risk of Ischemic Heart Disease: A Prospective Study of 7198 Incident Cases Among 409,885 Participants in the Pan-European EPIC Cohort.

Circulation 2019 Apr 22. Epub 2019 Apr 22.

MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

Background: There is uncertainty about the relevance of animal foods to the etiology of ischemic heart disease (IHD). We examined meat, fish, dairy products and eggs and risk for IHD in the pan-European EPIC cohort.

Methods: A prospective study of 409,885 men and women in nine European countries. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.038813DOI Listing

Children Born to Mothers with Rash During Zika Virus Epidemic in Brazil: First 18 Months of Life.

J Trop Pediatr 2019 Apr 21. Epub 2019 Apr 21.

Faculdade de Medicina, Universidade Federal Fluminense, RJ 24.033-900, Brazil.

Objective: To better understand the clinical spectrum and course of congenital Zika syndrome (CZS) during the first 18 months of life of children whose mothers had rash during pregnancy.

Methods: This longitudinal observational study evaluated the clinical progress from birth until 18 months of life of children of mothers who developed rash during or up to 3 months before gestation. Maternal rash occurred from November 2015 to May 2017. Read More

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https://academic.oup.com/tropej/advance-article/doi/10.1093/
Publisher Site
http://dx.doi.org/10.1093/tropej/fmz019DOI Listing
April 2019
1 Read

The Combined Use of Pleural Fluid Parameters Improves Diagnostic Accuracy in Complicated Pleural Infection/Empyema.

Arch Bronconeumol 2019 Apr 17. Epub 2019 Apr 17.

Servicio de Neumología, Complejo Hospitalario Clínico Universitario de Santiago de Compostela, Grupo Interdisciplinar de Investigación en Neumología. Instituto de Investigaciones Sanitarias de Santiago (IDIS), Santiago de Compostela, A Coruña, España.

Introduction: Identifying infectious pleural effusions (IPE) that will progress to complicated infection or empyema is challenging. The purpose of this study was to determine whether a model based on multiple biochemical parameters in pleural fluid can predict which IPEs will produce empyema.

Methods: A prospective study was performed of all cases of IPEs treated in our unit. Read More

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http://dx.doi.org/10.1016/j.arbres.2019.02.025DOI Listing

Role of Leptin in the Association Between Body Adiposity and Persistent Asthma: A Longitudinal Study.

Obesity (Silver Spring) 2019 Apr 20. Epub 2019 Apr 20.

VIMA: Aging and Chronic Diseases, Epidemiological and Public Health Approaches, INSERM U1168, Villejuif, France.

Objective: Obesity is a likely risk factor for asthma. However, underlying mechanisms by which obesity affects asthma activity remain poorly understood. This study aimed to investigate the role of leptin, an adipocyte-derived proinflammatory protein, as a mediator in the association between body adiposity (assessed using BMI, waist circumference, and body fat percentage) and persistent asthma. Read More

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http://dx.doi.org/10.1002/oby.22466DOI Listing
April 2019
1 Read
3.734 Impact Factor

Anthropogenic Effects on Natural Mammalian Populations: Correlation Between Telomere Length and Coal Exposure.

Sci Rep 2019 Apr 19;9(1):6325. Epub 2019 Apr 19.

Department of Genetics, Federal University of Rio Grande do Sul, C.P. 15053, 91501-970, Porto Alegre, RS, Brazil.

The Candiota coal mine in Rio Grande do Sul (RS) is one of the largest in Brazil. Coal is a fossil fuel that causes environmental impacts from its extraction to combustion due to the release of different agents, such as polycyclic aromatic hydrocarbons (PAH) and heavy metals. Ctenomys torquatus are herbivorous and subterranean rodents that dig tunnels with their paws and teeth and can be exposed to coal through contaminated food. Read More

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http://www.nature.com/articles/s41598-019-42804-8
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http://dx.doi.org/10.1038/s41598-019-42804-8DOI Listing
April 2019
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Comparison of Risk of Osteoporotic Fracture in Denosumab vs Alendronate Treatment Within 3 Years of Initiation.

JAMA Netw Open 2019 Apr 5;2(4):e192416. Epub 2019 Apr 5.

Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.

Importance: Head-to-head randomized clinical trials showed greater efficacy of denosumab vs alendronate in improving bone mineral density. Although there is an association of changes in bone mineral density with reductions in fracture risk, the magnitude of the association is not well established.

Objective: To compare the risk of hip and any fracture in patients treated with denosumab and alendronate in routine practice settings. Read More

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http://jamanetworkopen.jamanetwork.com/article.aspx?doi=10.1
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http://dx.doi.org/10.1001/jamanetworkopen.2019.2416DOI Listing
April 2019
1 Read

Recent advances in managing/understanding the metabolic syndrome.

F1000Res 2019 3;8. Epub 2019 Apr 3.

Unidad de Investigación en Enfermedades Metabólicas, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, 14008, Mexico.

The metabolic syndrome (MetS) concept gathers in a single entity a set of metabolic abnormalities that have in common a close relationship with ectopic deposit of lipids, insulin resistance, and chronic low-grade inflammation. It is a valuable teaching tool to help health professionals to understand and integrate the consequences of lipotoxicity and the adverse metabolic consequences of insulin resistance. Also, it is useful to identify subjects with a high risk for having incident type 2 diabetes. Read More

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https://f1000research.com/articles/8-370/v1
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http://dx.doi.org/10.12688/f1000research.17122.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449786PMC
April 2019
1 Read

Diverse Large HIV-1 Non-subtype B Clusters Are Spreading Among Men Who Have Sex With Men in Spain.

Front Microbiol 2019 3;10:655. Epub 2019 Apr 3.

HIV Biology and Variability Unit, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain.

In Western Europe, the HIV-1 epidemic among men who have sex with men (MSM) is dominated by subtype B. However, recently, other genetic forms have been reported to circulate in this population, as evidenced by their grouping in clusters predominantly comprising European individuals. Here we describe four large HIV-1 non-subtype B clusters spreading among MSM in Spain. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457325PMC

[Influence of diagnostic pathway on clinical and non-conventional therapies use in women with breast cancer of the cohort DAMA].

Gac Sanit 2019 Apr 15. Epub 2019 Apr 15.

Agència de Salut Pública de Barcelona, Barcelona, España; CIBER de Epidemiología y Salud Pública (CIBERESP), España; Institut de Recerca Biomèdica Sant Pau, Barcelona, España.

Objective: To describe and analyze the characteristics of breast cancer tumours according to the diagnostic pathway. We analyse the adverse effects of the treatments and the use of unconventional therapies in order to alleviate them.

Method: Descriptive design nested in a mixed cohort (Cohort DAMA). Read More

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http://dx.doi.org/10.1016/j.gaceta.2019.02.006DOI Listing

Correction to: Evaluation of the mortality registry in Ecuador (2001-2013) - social and geographical inequalities in completeness and quality.

Popul Health Metr 2019 Apr 18;17(1). Epub 2019 Apr 18.

Agència de Salut Pública de Barcelona, Plaça Lesseps 1, 08023, Barcelona, Catalonia, Spain.

Following the publication of this article [1], the authors reported a typesetting error in Table 1 that caused the columns of the table to be ordered incorrectly, and a typographical error in a sentence in the Conclusions section. Read More

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http://dx.doi.org/10.1186/s12963-019-0185-9DOI Listing

Tuberculosis care for migrant patients in Portugal: a mixed methods study with primary healthcare providers.

BMC Health Serv Res 2019 Apr 18;19(1):233. Epub 2019 Apr 18.

Global Health and Tropical Medicine, GHTM, Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, UNL, Rua da Junqueira 100, 1349-008, Lisbon, Portugal.

Background: Tuberculosis (TB) is still a major global health problem. The increasing number of cases observed among foreign-born populations contrasts with the decreasing trends observed in later years in some high-income countries. Healthcare providers are key interveners in the control of TB and HIV-TB infections. Read More

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http://dx.doi.org/10.1186/s12913-019-4050-0DOI Listing

Seroprevalence of Neospora caninum and Toxoplasma gondii in dogs from an urban area of North-eastern Brazil: a spatial approach.

Rev Soc Bras Med Trop 2019 Apr 11;52:e20180440. Epub 2019 Apr 11.

Unidade Acadêmica de Garanhuns, Universidade Federal Rural de Pernambuco, Garanhuns, PE, Brasil.

Introduction: The present study aimed to assess the seroprevalence and spatial distribution of Neospora caninum and Toxoplasma gondii in dogs.

Methods: Blood samples (n = 241) were collected and analyzed for the presence of anti-N. caninum and anti-T. Read More

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http://dx.doi.org/10.1590/0037-8682-0440-2018DOI Listing

Cost-effectiveness analysis of diagnostic-therapeutic strategies for visceral leishmaniasis in Brazil.

Rev Soc Bras Med Trop 2019 Apr 11;52:e20180272. Epub 2019 Apr 11.

Instituto de Avaliação de Tecnologia em Saúde, Porto Alegre, RS, Brasil.

Introduction: Visceral leishmaniasis (VL) is fatal if not diagnosed and treated. This study aimed to estimate the cost-effectiveness of diagnostic-therapeutic alternatives for VL in Brazil.

Methods: A decision model estimated the life expectancy and costs of six diagnostic-therapeutic strategies. Read More

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http://dx.doi.org/10.1590/0037-8682-0272-2018DOI Listing

Workshop for priority-setting in Aedes aegypti control interventions in Latin America and the Caribbean: a policy dialogue.

Cad Saude Publica 2019 8;35(4):e00092918. Epub 2019 Apr 8.

Hospital Prof. Dr. Juan P. Garrahan, Buenos Aires, Argentina.

This article presents the results of a dialogue between decision-makers and experts in Latin America and the Caribbean on priority-setting for interventions and studies on Aedes aegypti control. The article is part of a project that included a systematic review of mosquito control strategies and a qualitative study with key informants from the region. Using a collective deliberative process assisted by the results of the above-mentioned projects, a list of priorities was developed by consensus for the implementation of vector control strategies and the development of key regional research lines. Read More

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http://dx.doi.org/10.1590/0102-311X00092918DOI Listing

A Computer Application to Predict Adverse Events in the Short-Term Evolution of Patients With Exacerbation of Chronic Obstructive Pulmonary Disease.

JMIR Med Inform 2019 04 17;7(2):e10773. Epub 2019 Apr 17.

Red de Investigación en Servicios Sanitarios en Enfermedades Crónicas, Galdakao, Spain.

Background: Chronic obstructive pulmonary disease (COPD) is a common chronic disease. Exacerbations of COPD (eCOPD) contribute to the worsening of the disease and the patient's evolution. There are some clinical prediction rules that may help to stratify patients with eCOPD by their risk of poor evolution or adverse events. Read More

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http://dx.doi.org/10.2196/10773DOI Listing
April 2019
1 Read

Pre-marital predictors of marital violence in the WHO World Mental Health (WMH) Surveys.

Soc Psychiatry Psychiatr Epidemiol 2019 Apr 16. Epub 2019 Apr 16.

Department of Behavioral Medicine and Psychiatry, School of Medicine, West Virginia University, 64 Medical Center Drive, Morgantown, WV, 26506, USA.

Purpose: Intimate partner violence (IPV) is a pervasive public health problem. Existing research has focused on reports from victims and few studies have considered pre-marital factors. The main objective of this study was to identify pre-marital predictors of IPV in the current marriage using information obtained from husbands and wives. Read More

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http://link.springer.com/10.1007/s00127-019-01703-z
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http://dx.doi.org/10.1007/s00127-019-01703-zDOI Listing
April 2019
1 Read

Household food insecurity and socio-demographic determinants in young adults: findings from a Portuguese population-based sample.

Int J Public Health 2019 Apr 16. Epub 2019 Apr 16.

EPIUnit - Instituto de Saúde Pública, Universidade do Porto, Rua das Taipas, nº 135, 4050-600, Porto, Portugal.

Objectives: This study evaluated the prevalence and the socio-demographic determinants of food insecurity among young adults at a time of economic crisis recovery.

Methods: A cross-sectional study including 954 young adults (26 years old) from the EPITeen cohort (Porto, Portugal) was conducted. Food security status was evaluated using the US Household Food Security Survey Module: Six-Item Short Form. Read More

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http://dx.doi.org/10.1007/s00038-019-01243-yDOI Listing

A Review of Defined Oxidative Balance Scores Relative to Their Components and Impact on Health Outcomes.

Nutrients 2019 Apr 3;11(4). Epub 2019 Apr 3.

Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain.

Oxidative Balance Scores (OBSs) are tools that have emerged to evaluate the global balance of individuals' oxidation-reduction status. The aim was to compare OBSs available in the literature regarding their characteristics and associations with chronic diseases in epidemiological studies. Studies that developed OBSs were searched in PubMed until August 2018. Read More

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http://dx.doi.org/10.3390/nu11040774DOI Listing
April 2019
1 Read

Concentrations of bisphenol A and parabens in socks for infants and young children in Spain and their hormone-like activities.

Environ Int 2019 Apr 12;127:592-600. Epub 2019 Apr 12.

Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Granada E-18012, Spain; CIBER de Epidemiología y Salud Pública (CIBERESP), Granada E-18071, Spain; Centro de Investigación Biomédica (CIBM), Universidad de Granada, Granada E-18016, Spain; Departamento de Radiología y Medicina Física, Facultad de Medicina, Universidad de Granada, Granada E-18016, Spain; Unidad de Gestión Clínica de Medicina Nuclear, Hospital Universitario San Cecilio, Granada E-18016, Spain. Electronic address:

Background: Little information is available on the content of bisphenol A (BPA) and other endocrine-disrupting chemicals (EDCs) such as parabens in infant textiles and clothes.

Objectives: 1) To determine the concentrations of BPA and parabens in socks for infants and young children purchased in Spain, 2) to assess the (anti-)estrogenicity and (anti-)androgenicity of extracts from the socks, and 3) to estimate dermal exposure doses to these chemicals.

Methods: Thirty-two pairs of socks for infants and young children (1-48 months) were purchased from 3 stores in Granada (Spain). Read More

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http://dx.doi.org/10.1016/j.envint.2019.04.013DOI Listing
April 2019
1 Read

Osteoarticular infections: Blood as a determinant factor in the isolation of Kingella kingae.

J Microbiol Methods 2019 Apr 12;161:8-11. Epub 2019 Apr 12.

Servei de Microbiologia, Hospital Sant Joan de Déu, Barcelona, Spain. Electronic address:

We assessed the capacity of Kingella kingae to grow in blood culture bottles (BCB), taking into account the concentrations of the microorganism and blood in the culture medium. An initial suspension (McFarland 0.5) of 32 strains of K. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01677012193027
Publisher Site
http://dx.doi.org/10.1016/j.mimet.2019.04.009DOI Listing
April 2019
2 Reads

Supplementation with micronutrients and schistosomiasis: systematic review and meta-analysis.

Pathog Glob Health 2019 Apr 14:1-8. Epub 2019 Apr 14.

a Área de Medicina Preventiva y Salud Pública, Departamento de Medicina Preventiva y Salud Pública, Ciencias de la Alimentación, Toxicología y Medicina Legal, Facultad de Farmacia , Universitat de Valencia , Burjasot, Valencia , Spain.

Schistosomiasis is a parasitic disease caused by helminths of the genus Schistosoma with two presentations; one intestinal and another urinary; which depend on the specie of Schistosoma. One of the species that can produce intestinal schistosomiasis is Schistosoma mansoni, and the specie that produces urinary schistosomiasis is Schistosoma haematobium. Infection can be aggravated by a deficient nutritional status, which negatively impacts the immune system and increases susceptibility to infection. Read More

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http://dx.doi.org/10.1080/20477724.2019.1603902DOI Listing
April 2019
2 Reads

Social Profile of Patients Admitted for COPD Exacerbations. A Gender Analysis.

Arch Bronconeumol 2019 Apr 11. Epub 2019 Apr 11.

Grupo NeumoVigo I+i. Instituto de Investigación Sanitaria Galicia Sur (IISGS). Servicio de Neumología, Hospital Álvaro Cunqueiro, Vigo, Pontevedra, España. Electronic address:

Objective: To describe and compare from a gender perspective the social profile of patients admitted to a respiratory unit for COPD exacerbations (COPDE).

Methodology: A cross-sectional study in patients with serious COPDE in which demographic, clinical, and social data (economic situation, care, dependency for basic and instrumental activities, social risk, caregiver overload, use of social services) were collected using questionnaires and indices such as Barthel, Lawton-Brody, Zarit, Barber, and Gijón. A descriptive analysis was made of patients' social and healthcare situation, compared on the basis of gender. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03002896193012
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http://dx.doi.org/10.1016/j.arbres.2019.03.009DOI Listing
April 2019
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Reasons for noncompliance with the national guidelines for initial antiretroviral therapy of HIV-infected patients in Spain, 2010-2015.

Enferm Infecc Microbiol Clin 2019 Apr 11. Epub 2019 Apr 11.

Centro Nacional de Epidemiología, Instituto de Salud Carlos III, Madrid, Spain.

Introduction: Our aims were to investigate the adherence to national guidelines of initial antiretroviral therapy (ART) in the Spanish multicenter CoRIS cohort during the years 2010-2015, to identify the reasons for the prescription of nonrecommended treatments, and to explore the role of institutional constraints to guideline compliance.

Methods: ART regimens were classified as recommended, alternative or nonrecommended according to the guidelines. Physicians were asked the reasons for prescribing nonrecommended regimens. Read More

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http://dx.doi.org/10.1016/j.eimc.2019.02.007DOI Listing

[Differential impact and heterogeneous needs. A peer-led training program for improving chronic patients' health status and health behaviors].

Aten Primaria 2019 Apr 11. Epub 2019 Apr 11.

Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, España; Escuela Andaluza de Salud Pública, Granada, España; Instituto de Investigación Biosanitaria de Granada, Granada, España.

Objective: To measure the impact of the peer-led training for chronic patients on their health status and behaviors.

Design: Descriptive, transversal pretest and posttest quantitative approach.

Placement: Andalusia. Read More

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http://dx.doi.org/10.1016/j.aprim.2018.09.020DOI Listing
April 2019
2 Reads

Smoking Impairs the Immunomodulatory Capacity of Lung Resident Mesenchymal Stem Cells in COPD.

Am J Respir Cell Mol Biol 2019 Apr 12. Epub 2019 Apr 12.

Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain ;

Tobacco smoking is the main environmental risk factor of Chronic Obstructive Pulmonary Disease (COPD), but not all smokers develop the disease. A population of lung resident mesenchymal stem cells (LR-MSC) exist in healthy lungs, but how tobacco smoking affects them and their role in COPD have not been assessed yet. Using a sphere based culture technique, LR-MSC were isolated from lung tissue obtained from non-smokers, current and former smokers with and without COPD (n=53). Read More

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https://www.atsjournals.org/doi/10.1165/rcmb.2018-0351OC
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http://dx.doi.org/10.1165/rcmb.2018-0351OCDOI Listing
April 2019
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Cumulative Prognostic Score Predicting Mortality in Patients Older Than 80 Years Admitted to the ICU.

J Am Geriatr Soc 2019 Apr 12. Epub 2019 Apr 12.

Assistance Publique - Hôpitaux de Paris, Hôpital Saint-Antoine, Service de Réanimation Médicale, Paris, France.

Objectives: To develop a scoring system model that predicts mortality within 30 days of admission of patients older than 80 years admitted to intensive care units (ICUs).

Design: Prospective cohort study.

Setting: A total of 306 ICUs from 24 European countries. Read More

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http://dx.doi.org/10.1111/jgs.15888DOI Listing
April 2019
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Ultrasonographic 'soft' markers for the detection of rectosigmoid endometriosis.

Ultrasound Obstet Gynecol 2019 Apr 11. Epub 2019 Apr 11.

Department of Obstetrics and Gynecology, Clínica Universidad de Navarra, School of Medicine, University of Navarra, Pamplona, Spain.

Objectives: Due to the reported high sensitivity and specificity of ultrasound in the detection rate of rectosigmoid (RS) endometriosis when performed by an ultrasonographic (US) expert, this test should be considered a gold standard comparable to laparoscopy. No information is available regarding US soft markers in this disease. The aim of this study was to evaluate the use of US soft markers as "first level" examination in the suspicion of RS endometriosis. Read More

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http://dx.doi.org/10.1002/uog.20289DOI Listing
April 2019
2 Reads

Traffic noise and respiratory diseases: is there evidence?

Arch Bronconeumol 2019 Apr 7. Epub 2019 Apr 7.

Departamento de Epidemiología y Bioestadística, Escuela Nacional de Sanidad, Instituto de Salud Carlos III, Madrid, España. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03002896193011
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http://dx.doi.org/10.1016/j.arbres.2019.03.005DOI Listing
April 2019
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Association between site of infection and in-hospital mortality in patients with sepsis admitted to emergency departments of tertiary hospitals in Medellin, Colombia.

Rev Bras Ter Intensiva 2019 Jan-Mar;31(1):47-56

Grupo Académico de Epidemiología Clínica, Universidad de Antioquia - Medellín, Colombia.

Objective: To determine the association between the primary site of infection and in-hospital mortality as the main outcome, or the need for admission to the intensive care unit as a secondary outcome, in patients with sepsis admitted to the emergency department.

Methods: This was a secondary analysis of a multicenter prospective cohort. Patients included in the study were older than 18 years with a diagnosis of severe sepsis or septic shock who were admitted to the emergency departments of three tertiary care hospitals. Read More

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http://dx.doi.org/10.5935/0103-507X.20190011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443304PMC
August 2018
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Mediation analysis of the alcohol-postmenopausal breast cancer relationship by sex hormones in the EPIC Cohort.

Int J Cancer 2019 Apr 10. Epub 2019 Apr 10.

Nutritional Methodology and Biostatistics Group, International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, 69008 Lyon, France.

Alcohol consumption is associated with higher risk of breast cancer (BC); however, the biological mechanisms underlying this association are not fully elucidated, particularly the extent to which this relationship is mediated by sex hormone levels. Circulating concentrations of estradiol, testosterone, their free fractions and sex-hormone binding globulin (SHBG), were examined in 430 incident BC cases and 645 matched controls among alcohol-consuming postmenopausal women nested within the European Prospective Investigation into Cancer and Nutrition. Mediation analysis was applied to assess whether individual hormone levels mediated the relationship between alcohol intake and BC risk. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.32324
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http://dx.doi.org/10.1002/ijc.32324DOI Listing
April 2019
5 Reads

Communication and health education in communities experiencing asbestos risk and health impacts in Italy.

Ann Ist Super Sanita 2019 Jan-Mar;55(1):70-79

Dipartimento Ambiente e Salute, Istituto Superiore di Sanità, Rome, Italy - WHO Collaborating Centre for Environmental Health in Contaminated Sites, Istituto Superiore di Sanità,Rome, Italy.

Introduction: Numerous municipalities in Italy currently experience asbestos health impact, in particular excesses of pleural mesothelioma incidence and mortality. This paper presents an integrated analysis of epidemiological studies and communication actions in affected municipalities to highlight how communication has been implemented depending on health impact evidence and involvement of local stakeholders.

Methodology: Four case studies are identified concerning industrial and natural sources of asbestos exposure having different diseases burden. Read More

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http://dx.doi.org/10.4415/ANN_19_01_14DOI Listing
April 2019
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Hospital discharge diagnoses in patients with positive blood cultures in an Italian academic hospital.

Ann Ist Super Sanita 2019 Jan-Mar;55(1):19-25

SOC Microbiologia, Azienda Sanitaria Universitaria Integrata di Udine, Udine, Italy.

Objective: To assess the sensitivity of hospital discharge diagnoses for identifying sepsis in patients with blood culture confirmation.

Methods: A cross-sectional study was conducted at the Italian 1000-bed University Hospital of Udine. The administrative databases of the Hospital were used as the source of information. Read More

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http://dx.doi.org/10.4415/ANN_19_01_05DOI Listing

Exome sequencing identifies germline variants in DIS3 in familial multiple myeloma.

Leukemia 2019 Apr 9. Epub 2019 Apr 9.

ProfilExpert, Lyon, France.

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http://dx.doi.org/10.1038/s41375-019-0452-6DOI Listing
April 2019
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10.431 Impact Factor

Sepsis in the emergency department: key points, controversies, and proposals for improvements in Latin America.

Emergencias 2019 Abr;31(2):123-135

Sociedad Mexicana de Medicina de Emergencia A.C., México. Unidad de Cuidados Intensivos Adultos. Hospital Juárez de México. México D.F., México.

En: Although infection rates and the impact of infection on hospital emergency departments (EDs) are known or can be reliably estimated, the incidence and prevalence of sepsis vary in relation to which definitions or registers used. Sepsis is also well known to be under-diagnosed by physicians in general and by ED physicians in particular. Over half of sepsis cases are community-acquired, and 50% to 60% of patients in intensive care units (ICUs) with sepsis or septic shock are admitted directly from the ED. Read More

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April 2019
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Medication overdoses: changes over time.

Emergencias 2019 Abr;31(2):107-110

Área de Metodología de las Ciencias del Comportamiento, Departamento de Psicología de la Universitat de les Illes Balears. Grupo de Trabajo en Procedimientos Estadísticos y Psicométricos Aplicados en Ciencias de la Salud del Institut d'Investigació Sanitària de Baleares (IdiSBA), España.

Objectives: To measure cervical spine movement during removal of a motorcycle helmet by health care professionals.

Material And Methods: Observational study using biomechanical inertial sensors to detect movement in the spinal column during removal of helmets.

Results: Thirty-four emergency medicine specialists and nurses participated. Read More

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