10,896 results match your criteria Epidemiologia & Prevenzione [Journal]


Citrus fruit intake and gastric cancer: the Stomach cancer Pooling (StoP) project consortium.

Int J Cancer 2018 Dec 6. Epub 2018 Dec 6.

Department of Clinical Sciences and Community Health, Università degli Studi di Milano, 20133 Milan, Italy.

Diets rich in vegetables and fruit have been associated with reduced risk of gastric cancer, and there is suggestive evidence that citrus fruits have a protective role. This study aimed at evaluating and quantifying the association between citrus fruit consumption and gastric cancer risk. We conducted a one-stage pooled analysis including 6340 cases and 14,490 controls from 15 case-control studies from the Stomach cancer Pooling (StoP) Project consortium. Read More

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December 2018
2 Reads
5.085 Impact Factor

Methods for trustworthy nutritional recommendations NutriRECS (Nutritional Recommendations and accessible Evidence summaries Composed of Systematic reviews): a protocol.

BMC Med Res Methodol 2018 Dec 5;18(1):162. Epub 2018 Dec 5.

Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.

Background: Recent systematic reviews and editorials suggest that many organizations that produce nutritional guideline recommendations do not adhere to internationally recognized standards set forth by the Institute of Medicine (IoM), Guidelines International Network (GIN), Appraisal of Guidelines Research and Evaluation (AGREE), and Grading Recommendations, Assessment, Development and Evaluation (GRADE).

Methods: The potential solution is an independent group with content expertise and skilled in the methodology of systematic reviews and practice guidelines to produce trustworthy guideline recommendations, recommendations that are supported by publication in a top tier journal. The BMJ Rapid Recommendations project has recently demonstrated the feasibility and utility of this approach. Read More

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December 2018

The impact of the economic recession on inequalities in induced abortion in the main cities of Spain.

Eur J Public Health 2018 Nov 30. Epub 2018 Nov 30.

Dirección General de Salud Pública, Consejería de Sanidad, Madrid, Spain.

The aim of this study was to analyse the trends in socioeconomic inequalities in induced abortion during the pre-crisis and crisis periods in the postcodes of two major cities of Spain. Ecological regression model showed that rates of induced abortion tended to increase between the two pre-crisis periods, but remained stable between the second pre-crisis period and the crisis period. In addition, we observed socioeconomic inequalities in induced abortion in both cities and in all age groups, and that these inequalities persisted across the three study periods. Read More

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November 2018
1 Read

Common fetal hemoglobin variants in Lebanese patients bearing the codon 29 beta gene mutation associated with different thalassemia phenotypes.

Ann Hematol 2018 Nov 30. Epub 2018 Nov 30.

Department of Internal Medicine, American University of Beirut Medical Center, PO Box 11-0236, Beirut, 11072020, Lebanon.

Beta-thalassemia can present with a wide spectrum of phenotypes determined by the coinheritance of α-thalassemia, hereditary persistence of fetal hemoglobin, and polymorphic variants in the BCL11A, HMIP, and HBB clusters. The codon 29 (cd29) mutation in the beta gene has been associated with a broad diversity of thalassemia phenotypes, possibly through genetic modifiers determining the genotype-phenotype relationship. In this study, we evaluated the effect of 10 single nucleotide polymorphisms (SNPs) on β-thalassemia severity in a group of 21 Lebanese patients bearing the cd29 mutation. Read More

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November 2018

Green and blue spaces and physical functioning in older adults: Longitudinal analyses of the Whitehall II study.

Environ Int 2018 Nov 28. Epub 2018 Nov 28.

ISGlobal, Barcelona, Catalonia, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Catalonia, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. Electronic address:

There is increasing evidence of the health benefits of exposure to natural environments, including green and blue spaces. The association with physical functioning and its decline at older age remains to be explored. The aim of the present study was to investigate the longitudinal association between the natural environment and the decline in physical functioning in older adults. Read More

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November 2018

Plasma proprotein convertase subtilisin/kexin type 9 inhibitors and cataract risk: A systematic review and meta-analysis.

Arch Soc Esp Oftalmol 2018 Nov 29. Epub 2018 Nov 29.

Sociedad Argentina de Lípidos, Córdoba, Argentina; Facultad de Ciencias de la Salud, Universidad Nacional de Formosa, Formosa, Argentina.

Background: The marked decrease in LDL-C levels produced by the inhibitors of the plasma proprotein convertase subtilisin/kexin type 9 (iPCSK9) could be associated with an increased risk of cataracts.

Methods: A meta-analysis was performed that included randomised clinical trials controlled with iPCSK9, alone, or in combination with other lipid-lowering drugs, which reported new cases of cataracts, by searching PubMed/Medline, databases of EMBASE and Cochrane Clinical Trials. A fixed-effect model was used, and a meta-regression was carried out evaluating the relationship between intra-treatment LDL-C and the risk of developing cataracts. Read More

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November 2018

Factors associated with mortality in severe community-acquired pneumonia: A multicenter cohort study.

J Crit Care 2018 Nov 22;50:82-86. Epub 2018 Nov 22.

Programa de Pós-Graduação em Clínica Médica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.; Postgraduate Program, Instituto D'Or de Pesquisa e Ensino, Rio de Janeiro, Brazil.

Objective: Describe characteristics and outcomes of CAP admitted to public ICUs in Brazil.

Methods: Retrospective cohort study in 4 Tertiary Public Hospitals in Rio de Janeiro, Brazil during 2016. Patients admitted to ICUs with a diagnosis of community-acquired pneumonia were included. Read More

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November 2018

Varicella-zoster virus clades circulating in Spain over two decades.

J Clin Virol 2018 Nov 28;110:17-21. Epub 2018 Nov 28.

Centro Nacional de Microbiología (CNM), Instituto de Salud Carlos III, Majadahonda, Spain. Electronic address:

Background: Despite childhood universal VZV immunization was introduced in 2015, there are no data on VZV clade distribution in Spain.

Objectives: To characterize the varicella-zoster virus strains circulating in Spain between 1997 and 2016.

Study Design: In this retrospective study, we determined the VZV clades in 294 patients with different pathologies (mainly encephalitis, zoster and varicella) by sequencing three fragments within ORF 22, ORF 21 and ORF 50 and, subsequently analyzing 7 relevant SNPs. Read More

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November 2018
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Pre-treatment drug resistance and HIV-1 subtypes in infants from Argentina with and without exposure to antiretroviral drugs for prevention of mother-to-child transmission.

J Antimicrob Chemother 2018 Dec 5. Epub 2018 Dec 5.

Laboratorio de Biología Celular y Retrovirus, Hospital de Pediatría "Juan P. Garrahan"-CONICET, Buenos Aires, Argentina.

Objectives: To assess the prevalence and patterns of pre-treatment HIV drug resistance (PDR) and HIV-1 subtype in infants from Argentina with exposure to different antiretroviral drugs (ARVs) for the prevention of mother-to-child transmission (PMTCT).

Patients And Methods: HIV-1 genotyping was performed in 115 infants (median age = 2.3 months) born between 2007 and 2014 to screen for drug resistance mutations (DRMs) before starting first-line ART. Read More

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December 2018
1 Read

[Association between food availability and mortality due to colorectal cancer in the Americas].

Authors:
Susana Buamden

Salud Colect 2018 Jul-Sep;14(3):579-595

Licenciada en Nutrición, Magíster en Epidemiología, Gestión y Políticas de Salud. Docente adscripta, Universidad de Buenos Aires, Ciudad autónoma de Buenos Aires, Argentina.

With the aim of describing the association between food availability and the mortality rate due to colorectal cancer in the countries of the Americas in 2010, data provided by the International Agency for Research on Cancer and the Food and Agriculture Federation were analyzed in an ecological study. Great variability was observed except in caloric supply. Food availability was abundant for calories, total fats, animal fat, red meat and alcoholic beverages. Read More

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August 2017
2 Reads

Antiprotozoal action of synthetic cinnamic acid analogs.

Rev Soc Bras Med Trop 2018 Nov-Dec;51(6):849-853

Plataforma de Bioensaios em Malária e Leishmaniose, Fundação Oswaldo Cruz, Porto Velho, RO, Brasil.

Introduction: Leishmaniasis, Chagas disease, and malaria cause morbidity globally. The drugs currently used for treatment have limitations. Activity of cinnamic acid analogs against Leishmania spp. Read More

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December 2017
2 Reads

Alterations in the lipid profiles and circulating liver enzymes in individuals infected by Schistosoma mansoni.

Rev Soc Bras Med Trop 2018 Nov-Dec;51(6):795-801

Laboratório Avançado de Saúde Pública, Instituto Gonçalo Moniz, Salvador, BA, Brasil.

Introduction: Portal hypertension and periportal fibrosis commonly occur in severe Schistosoma mansoni infection. Changes in lipid profile and elevated levels of circulating liver enzymes have also been described in infected individuals. The present study sought to assess the alterations in laboratory parameters associated with liver disorder in individuals infected by S. Read More

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Favorable responses to treatment with 5 mg Sbv/kg/day meglumine antimoniate in patients with American tegumentary leishmaniasis acquired in different Brazilian regions.

Rev Soc Bras Med Trop 2018 Nov-Dec;51(6):769-780

Fundação Oswaldo Cruz, Instituto Nacional de Infectologia Evandro Chagas, Laboratório de Pesquisa Clínica e Vigilância em Leishmanioses, Rio de Janeiro, RJ, Brasil.

Introduction: Favorable responses in American tegumentary leishmaniasis (ATL) patients to treatment with 5 mg Sbv/kg/day meglumine antimoniate (MA) has been reported in Rio de Janeiro, but little is known regarding the therapeutic response to low doses in patients from other locations.

Methods: A retrospective review of medical records was conducted to compare the therapeutic response to 5 mg Sbv/kg/day MA treatment among 36 patients who acquired ATL in Brazilian states other than Rio de Janeiro (OS group) and 72 patients from Rio de Janeiro (RJ group).

Results: One course of 5 mg Sbv/kg/day MA cured 72. Read More

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December 2017
1 Read

What is the importance of vaccine hesitancy in the drop of vaccination coverage in Brazil?

Rev Saude Publica 2018 Nov 29;52:96. Epub 2018 Nov 29.

Universidade de São Paulo. Faculdade de Saúde Pública. Departamento de Epidemiologia. São Paulo, SP, Brasil.

The successful Programa Nacional de Imunizações do Brasil (Brazilian National Immunization Program) has been experiencing a major challenge with regard to vaccination coverage for children, which has been dropping. Several aspects are related, but certainly vaccine hesitancy has been strengthening itself as one of the main concerns of Brazilian public administrators and researchers. Vaccine hesitancy is the delay in acceptance or refusal despite having the recommended vaccines available in health services, being a phenomenon that varies over time, over location and over types of vaccines. Read More

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November 2018
1 Read

[Health-related out-of-pocket expenses in older peruvian adults: analysis of the national household survey on living conditions and poverty 2017].

Rev Peru Med Exp Salud Publica 2018 Jul-Sep;35(3):390-399

Departamento de Epidemiología Clínica y Bioestadística, Facultad de Medicina, Pontificia Universidad Javeriana. Bogotá, Colombia.

Objectives: . To estimate out-of-pocket spending on health (GBS) and identify its associated factors in Peruvian older adults.

Materials And Methods. Read More

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[Reply: on the evaluation of post- traumatic stress disorder in individuals affected by el niño].

Rev Peru Med Exp Salud Publica 2018 Jul-Sep;35(3):541

Oficina de Inteligencia Sanitaria, Hospital Nacional Almanzor Aguinaga Asenjo EsSalud. Chiclayo, Perú.

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September 2018

Prevalence of physically active adolescents in Brazilian capitals: National Adolescent School-based Health Survey 2012 and 2015.

Rev Bras Epidemiol 2018 Nov 29;21(suppl 1):e180012. Epub 2018 Nov 29.

Observatório de Saúde Urbana de Belo Horizonte, Faculdade de Medicina, Universidade Federal de Minas Gerais - Belo Horizonte (MG), Brasil.

Objective: To compare the prevalence of physically active adolescents living in Brazilian capitals, using 2012 and 2015 National Adolescent School-based Health Survey.

Method: The sample consisted of 61,145 (2012) and 51,192 (2015) adolescents who were residents in 27 Brazilian capitals and were attending the 9th year of elementary school. The globally estimated physical activity indicator with the cutoff point of 300 minutes or more per week was used to determine the prevalence of physically active adolescents in both surveys. Read More

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November 2018
2 Reads

Prevalence and factors associated with illicit drug use throughout life: National School Health Survey 2015.

Rev Bras Epidemiol 2018 Nov 29;21(suppl 1):e180007. Epub 2018 Nov 29.

Escola de Enfermagem, Universidade Federal de Minas Gerais - Belo Horizonte (MG), Brasil.

Introduction: The use of illicit drugs is a public health concern. This paper describes the prevalence and factors associated with the use of illicit drugs throughout life among 9th grade students attending public and private schools in daylight period in Brazil.

Method: Data from the Brazilian Adolescent School-based Health Survey (PeNSE) were analyzed. Read More

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November 2018
3 Reads

Risk and protection factors for chronic noncommunicable diseases in adolescents in Brazilian capitals.

Rev Bras Epidemiol 2018 Nov 29;21(suppl 1):e180002. Epub 2018 Nov 29.

Departamento de Vigilância de Doenças e Agravos não Transmissíveis e Promoção da Saúde, Ministério da Saúde - Brasília (DF), Brasil.

Objective: To analyze trend estimates on the prevalence of risk and protective behaviors for chronic noncommunicable diseases in adolescents, according to data from the National School Health Survey in 2009, 2012 and 2015.

Methods: Data from the three cross-sectional studies in Brazilian capitals and the Federal District were used. In total, 173,310 adolescents enrolled in the ninth grade of elementary school were interviewed, with average age of 14 years. Read More

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November 2018

Neutrophils, eosinophils, and mast cells in the intestinal wall of dogs naturally infected with Leishmania infantum.

Rev Bras Parasitol Vet 2018 Oct-Dec;27(4):430-438

Departamento de Biologia e Ciência Animal, Faculdade de Engenharia de Ilha Solteira - FEIS, Universidade Estadual Paulista - UNESP, Ilha Solteira, SP, Brasil.

Visceral leishmaniasis (VL) is a disease caused by the protozoa Leishmania infantum and can cause an inflammatory reaction in the gastrointestinal tract, however the role of granulocytic cells (neutrophils, eosinophils, and mast cells) in the intestine of dogs infected is not fully understood. We performed a quantitative analysis these cells in the intestinal wall of dogs with canine visceral leishmaniasis (CVL). Twenty dogs were assigned to one of three groups: group 1 (G1, n=8), dogs with CVL and L. Read More

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April 2018
2 Reads

Reply to comment on the article "HIV/AIDS Mortality in Brazil, 2000-2015: Are there reasons for concern?

Rev Bras Epidemiol 2018 Dec 3;21:e180023. Epub 2018 Dec 3.

Grupo de Pesquisas em Epidemiologia e Avaliação em Saúde, Departamento de Medicina Preventiva e Social, Faculdade de Medicina, Universidade Federal de Minas Gerais - Belo Horizonte (MG), Brasil.

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December 2018

Nyssorhynchus dunhami: bionomics and natural infection by Plasmodium falciparum and P. vivax in the Peruvian Amazon.

Mem Inst Oswaldo Cruz 2018 Dec 3;113(12):e180380. Epub 2018 Dec 3.

University at Albany, State University of New York, School of Public Health, Department of Biomedical Sciences, Albany, NY, USA.

BACKGROUND Nyssorhynchus dunhami, a member of the Nuneztovari Complex, has been collected in Brazil, Colombia, and Peru and described as zoophilic. Although to date Ny. dunhami has not been documented to be naturally infected by Plasmodium, it is frequently misidentified as other Oswaldoi subgroup species that are local or regional malaria vectors. Read More

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December 2018
1 Read

Diffusing Capacity of the Lung for Carbon Monoxide in Mexican/Latino Children: Quality Control and Reference Values.

Ann Am Thorac Soc 2018 Dec 5. Epub 2018 Dec 5.

Medica Sur Clinic & Foundation, Mexico City, Tlalpan, Mexico.

Rationale: Single breath diffusing capacity of the lung for carbon monoxide (DLCOsb) evaluates gas exchange; however, the quality of maneuvers performed by children has not been evaluated, and reference values for young people living at moderate altitudes are not well established.

Objectives: 1) to determine whether DLCOsb maneuvers performed by a pediatric population would meet 2017 ERS/ATS quality control standards; and 2) to report normal DLCOsb values for Mexican/Latino children and adolescents living at moderate altitudes.

Methods: This study involved healthy young people aged 4-20 years from the metropolitan area of Mexico City (2,240 m above sea level) recruited in schools from July 2014 to August 2017. Read More

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December 2018

Differences in the relation between bone mineral content and lean body mass according to gender and reproductive status by age ranges.

J Bone Miner Metab 2018 Dec 4. Epub 2018 Dec 4.

Unidad Académica en Investigación Epidemiológica, Centro de Investigación en Políticas, Población y Salud, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico.

The present study aims: (1) to explore the influence of lean mass (LM) on bone mineral content (BMC), (2) to investigate the pubertal influences on the BMC-LM relation, and (3) to perform Z-score charts of BMC-LM relation, stratified by gender and reproductive status categorized by age ranges. A cross-sectional analysis was conducted using 4001 healthy subjects between 7 and 90 years participating in the Health Workers Cohort Study. Of these, 720 participants were ≤ 19 years, 2417 were women ≥ 20 years, and 864 were men ≥ 20 years. Read More

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December 2018
2 Reads

Hot springs as sources of infection: An environment overlooked by public health practitioners.

J Infect Public Health 2018 Dec 1. Epub 2018 Dec 1.

Hospital Regional de Duitama, Duitama, Boyacá, Colombia. Electronic address:

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December 2018

Losses to follow-up of HIV-infected people in the Spanish VACH cohort over the period between 2013 and 2014: The importance of sociodemographic factors.

Enferm Infecc Microbiol Clin 2018 Dec 1. Epub 2018 Dec 1.

Servicio de Enfermedades Infecciosas, Hospital Universitario de Basurto, Bilbao, Vizcaya, España.

Objective: To determine the proportion of people infected by HIV or AIDS under follow-up in the VACH Cohort in 2012 who were lost to follow-up from 2013 to 2014, and to establish the sociodemographic features relating to this loss.

Methods: We considered subjects with less than one recorded consultation per year studied to be lost to follow-up. We built logistic regression models to calculate the odds ratios (OR) and their 95% confidence intervals (95% CI), of the variables relating to loss to follow-up. Read More

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December 2018
1 Read

Distinctive Expression and Amplification of Genes at 11q13 in Relation to HPV Status with Impact on Survival in Head and Neck Cancer Patients.

J Clin Med 2018 Dec 1;7(12). Epub 2018 Dec 1.

Department of Otolaryngology, Hospital Universitario Central de Asturias and Instituto de Investigación Sanitaria del Principado de Asturias, Instituto Universitario de Oncología del Principado de Asturias, University of Oviedo, 33011 Oviedo, Spain.

Clear differences have been established between head and neck squamous cell carcinomas (HNSCC) depending on human papillomavirus (HPV) infection status. This study specifically investigated the status of the , and genes mapping at the 11q13 amplicon in relation to the HPV status in HNSCC patients. CTTN, CCND1 and ANO1 protein expression and gene amplification were respectively analyzed by immunohistochemistry and real-time PCR in a homogeneous cohort of 392 surgically treated HNSCC patients. Read More

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December 2018

Progress in the elimination of hepatitis C virus infection: A population-based cohort study in Spain.

PLoS One 2018 4;13(12):e0208554. Epub 2018 Dec 4.

Instituto de Salud Pública de Navarra-IdiSNA, Pamplona, Spain.

Background: The World Health Organization set targets to eliminate hepatitis C virus (HCV) infection through detection and treatment of all cases by 2030. This study aimed to describe the progress and difficulties in the elimination of HCV infection in Navarra, Spain.

Methods: Using electronic healthcare databases, we performed a population-based prospective cohort study to describe changes in the prevalence of diagnosed active HCV infection at the beginning of 2015 and the end of 2017, the rate of new diagnoses and the rate of post-treatment viral clearance (PTVC) during this period. Read More

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December 2018

Composition and Vertical Stratification of Phlebotomine Sand Fly Fauna and the Molecular Detection of Leishmania in Forested Areas in Rondônia State Municipalities, Western Amazon, Brazil.

Vector Borne Zoonotic Dis 2018 Dec 4. Epub 2018 Dec 4.

1 Laboratório de Entomologia, Fundação Oswaldo Cruz - Fiocruz Rondônia, Porto Velho, Rondônia, Brazil .

This study examined sand fly diversity and the natural infection of sand flies by Leishmania in three localities in Rondônia State: Santo Antônio and São Vicente farm, which are anthropized environments, and the Jamari FLONA, which has not been anthropized. Sand flies were collected in canopies and at ground level using CDC light traps and BG-Sentinel CO traps. Female sand flies were grouped into pools that were subjected to DNA extraction and the samples were subjected to PCR to detect and identify Leishmania. Read More

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December 2018
1 Read

Quality of clinical practice guidelines about red blood cell transfusion.

J Evid Based Med 2018 Dec 3. Epub 2018 Dec 3.

Iberomerican Cochrane Centre, Clinical Epidemiology and Public Health Department, Institute of Biomedical Research (IIB Sant Pau), CIBER de Epidemiología y Salud Pública (CIBERESP), Spain.

Background: Red blood cell (RBC) transfusions are essential in health care. The quality of recommendations included in clinical practice guidelines (CPG), regarding this intervention, has not been systematically evaluated. This paper systematically assessed CPGs for RBC-transfusion, to appraise their methodological quality, to explore changes in quality over time, and to assess the consistency of the hemoglobin threshold (HT) recommendations. Read More

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December 2018
1 Read

Discovery of common and rare genetic risk variants for colorectal cancer.

Authors:
Jeroen R Huyghe Stephanie A Bien Tabitha A Harrison Hyun Min Kang Sai Chen Stephanie L Schmit David V Conti Conghui Qu Jihyoun Jeon Christopher K Edlund Peyton Greenside Michael Wainberg Fredrick R Schumacher Joshua D Smith David M Levine Sarah C Nelson Nasa A Sinnott-Armstrong Demetrius Albanes M Henar Alonso Kristin Anderson Coral Arnau-Collell Volker Arndt Christina Bamia Barbara L Banbury John A Baron Sonja I Berndt Stéphane Bézieau D Timothy Bishop Juergen Boehm Heiner Boeing Hermann Brenner Stefanie Brezina Stephan Buch Daniel D Buchanan Andrea Burnett-Hartman Katja Butterbach Bette J Caan Peter T Campbell Christopher S Carlson Sergi Castellví-Bel Andrew T Chan Jenny Chang-Claude Stephen J Chanock Maria-Dolores Chirlaque Sang Hee Cho Charles M Connolly Amanda J Cross Katarina Cuk Keith R Curtis Albert de la Chapelle Kimberly F Doheny David Duggan Douglas F Easton Sjoerd G Elias Faye Elliott Dallas R English Edith J M Feskens Jane C Figueiredo Rocky Fischer Liesel M FitzGerald David Forman Manish Gala Steven Gallinger W James Gauderman Graham G Giles Elizabeth Gillanders Jian Gong Phyllis J Goodman William M Grady John S Grove Andrea Gsur Marc J Gunter Robert W Haile Jochen Hampe Heather Hampel Sophia Harlid Richard B Hayes Philipp Hofer Michael Hoffmeister John L Hopper Wan-Ling Hsu Wen-Yi Huang Thomas J Hudson David J Hunter Gemma Ibañez-Sanz Gregory E Idos Roxann Ingersoll Rebecca D Jackson Eric J Jacobs Mark A Jenkins Amit D Joshi Corinne E Joshu Temitope O Keku Timothy J Key Hyeong Rok Kim Emiko Kobayashi Laurence N Kolonel Charles Kooperberg Tilman Kühn Sébastien Küry Sun-Seog Kweon Susanna C Larsson Cecelia A Laurie Loic Le Marchand Suzanne M Leal Soo Chin Lee Flavio Lejbkowicz Mathieu Lemire Christopher I Li Li Li Wolfgang Lieb Yi Lin Annika Lindblom Noralane M Lindor Hua Ling Tin L Louie Satu Männistö Sanford D Markowitz Vicente Martín Giovanna Masala Caroline E McNeil Marilena Melas Roger L Milne Lorena Moreno Neil Murphy Robin Myte Alessio Naccarati Polly A Newcomb Kenneth Offit Shuji Ogino N Charlotte Onland-Moret Barbara Pardini Patrick S Parfrey Rachel Pearlman Vittorio Perduca Paul D P Pharoah Mila Pinchev Elizabeth A Platz Ross L Prentice Elizabeth Pugh Leon Raskin Gad Rennert Hedy S Rennert Elio Riboli Miguel Rodríguez-Barranco Jane Romm Lori C Sakoda Clemens Schafmayer Robert E Schoen Daniela Seminara Mitul Shah Tameka Shelford Min-Ho Shin Katerina Shulman Sabina Sieri Martha L Slattery Melissa C Southey Zsofia K Stadler Christa Stegmaier Yu-Ru Su Catherine M Tangen Stephen N Thibodeau Duncan C Thomas Sushma S Thomas Amanda E Toland Antonia Trichopoulou Cornelia M Ulrich David J Van Den Berg Franzel J B van Duijnhoven Bethany Van Guelpen Henk van Kranen Joseph Vijai Kala Visvanathan Pavel Vodicka Ludmila Vodickova Veronika Vymetalkova Korbinian Weigl Stephanie J Weinstein Emily White Aung Ko Win C Roland Wolf Alicja Wolk Michael O Woods Anna H Wu Syed H Zaidi Brent W Zanke Qing Zhang Wei Zheng Peter C Scacheri John D Potter Michael C Bassik Anshul Kundaje Graham Casey Victor Moreno Goncalo R Abecasis Deborah A Nickerson Stephen B Gruber Li Hsu Ulrike Peters

Nat Genet 2018 Dec 3. Epub 2018 Dec 3.

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence variants and Haplotype Reference Consortium panel variants into genome-wide association study data, and tested for association in 34,869 cases and 29,051 controls. Findings were followed up in an additional 23,262 cases and 38,296 controls. We discovered a strongly protective 0. Read More

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December 2018
3 Reads
29.352 Impact Factor

Infections with Mycobacterium chimaera and open chest surgery. An unresolved problem.

Med Clin (Barc) 2018 Nov 30. Epub 2018 Nov 30.

Servicio de Medicina Preventiva y Epidemiología, Hospital Universitario Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, España.

Mycobacterium chimaera (M. chimaera) is a non-tuberculous mycobacterium of the Mycobacterium avium complex. Between 2013 and April 2018, more than 140 cases of severe infection have been identified, all of them in patients who had undergone cardiothoracic surgery with extracorporeal circulation. Read More

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November 2018

Risk prediction for estrogen receptor-specific breast cancers in two large prospective cohorts.

Breast Cancer Res 2018 Dec 3;20(1):147. Epub 2018 Dec 3.

Nutritional Methodology and Biostatistics Group, Nutrition and Metabolism Section, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372, Lyon Cedex 08, France.

Background: Few published breast cancer (BC) risk prediction models consider the heterogeneity of predictor variables between estrogen-receptor positive (ER+) and negative (ER-) tumors. Using data from two large cohorts, we examined whether modeling this heterogeneity could improve prediction.

Methods: We built two models, for ER+ (Model) and ER- tumors (Model), respectively, in 281,330 women (51% postmenopausal at recruitment) from the European Prospective Investigation into Cancer and Nutrition cohort. Read More

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December 2018

The National Institutes of Health Patient-Reported Outcomes Measurement Information System (PROMIS): a view from the UK.

Patient Relat Outcome Meas 2018 24;9:345-352. Epub 2018 Oct 24.

Health Services and Policy Research Group, University of Exeter Medical School, Exeter, UK,

The interest in patient-reported outcome measures (PROMs) continues to increase as recognition of their potential utility rises in an effort to make health systems more patient-centered. The US National Institutes of Health (NIH) Patient-Reported Outcomes Measurement Information System (PROMIS) has used state of the art psychometric and statistical techniques to create a universal PROMs language, with potential application across the whole spectrum of health conditions, languages, and geographic locations. PROMIS offers a versatile platform where specific health domains are assessed using both standardized short forms and computerized adaptive tests, which are automatically tailored to individual patients. Read More

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October 2018

Oral benign neoplasms: A retrospective study of 790 patients over a 14-year period.

Acta Otorrinolaringol Esp 2018 Nov 26. Epub 2018 Nov 26.

Postgraduate Program in Oral Pathology, Federal University of Rio Grande do Norte, Natal, RN, Brazil.

Introduction And Objective: Oral benign neoplasms (OBNs) exhibit some features that can guide the professionals to the correct diagnosis and best treatment. Through retrospective studies, medical records can be reviewed to better describe a given population and, furthermore, help clinicians in routine practice. In this context, the objective of this paper was to analyze the cases of OBNs of an oral pathology referral department, from 2003 to 2017, in order to better understand their epidemiological and clinicopathological characteristics. Read More

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November 2018
1 Read

"Contribution of the clinical information to the accuracy of the minimally invasive and the complete diagnostic autopsy".

Hum Pathol 2018 Nov 26. Epub 2018 Nov 26.

Department of Pathology, Maputo, Central Hospital, 1100 Maputo, Mozambique; Faculty of Medicine, Eduardo Mondlane University, 1100 Maputo, Mozambique.

Although autopsy diagnosis includes routinely, a thorough evaluation of all available pathological results and also of any available clinical data, the contribution of this clinical information to the diagnostic yield of the autopsy has not been analyzed. We aimed to determine to which degree the use of clinical data improves the diagnostic accuracy of the complete diagnostic autopsy (CDA) and the minimally invasive autopsy (MIA), a simplified pathological postmortem procedure designed for low-income sites. 264 coupled MIA and CDA procedures (112 adults, 57 maternal deaths, 54 children and 41 neonates) were performed at the Maputo hospital, Mozambique. Read More

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November 2018
1 Read
2.769 Impact Factor

Gender differences in common mental disorders: a comparison of social risk factors across four European welfare regimes.

Eur J Public Health 2018 Nov 28. Epub 2018 Nov 28.

Ecole des Hautes Etudes en Santé Publique (EHESP), EA4057 Paris Descartes University, Paris, France.

Background: Decreasing gender differences in mental health are found largely in countries in which the roles of men and women have improved in terms of opportunities for employment, education, child care and other indicators of increasing gender equality. In this study, we examine how European welfare regimes influence this association between mental health and the social roles that men and women occupy.

Methods: The EU-World Mental Health data are used, which covers the general population in 10 European countries (n = 37 289); Countries were grouped into four welfare regions: Liberal regime (Northern Ireland), Bismarckian regime (Belgium, Germany, the Netherlands and France), Southern regime (Spain, Italy, Portugal) and Central-Eastern regime (Romania and Bulgaria). Read More

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November 2018

Helicobacter pylori seroprevalence in Spain: influence of adult and childhood sociodemographic factors.

Eur J Cancer Prev 2018 Nov 26. Epub 2018 Nov 26.

Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública, CIBERESP).

Helicobacter pylori (H. pylori) chronic infection causes severe digestive diseases, including gastric cancer, and certain strains entail a higher risk. Risk factors for this infection are still not fully understood. Read More

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November 2018
2 Reads

Impact of patient and public involvement on enrolment and retention in clinical trials: systematic review and meta-analysis.

BMJ 2018 Nov 28;363:k4738. Epub 2018 Nov 28.

Oxford Academic Health Science Network, Oxford, UK.

Objective: To investigate the impact of patient and public involvement (PPI) on rates of enrolment and retention in clinical trials and explore how this varies with the context and nature of PPI.

Design: Systematic review and meta-analysis.

Data Sources: Ten electronic databases, including Medline, INVOLVE Evidence Library, and clinical trial registries. Read More

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November 2018

Geometric morphometry of the head in sand flies (Diptera: Psychodidae: Phlebotominae), an alternative approach to taxonomy studies.

Zootaxa 2018 Oct 26;4504(4):566-576. Epub 2018 Oct 26.

Departamento de Epidemiologia, Faculdade de Saúde Pública, Universidade de São Paulo, São Paulo, SP, Brasil, 01246-904. Laboratório Interdisciplinar de Vigilância Entomológica em Diptera e Hemiptera, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Av. Brasil, 4365, Manguinhos, Rio de Janeiro, RJ, Brasil, 21040-360. Grupo de Estudos em Leishmanioses/Coleção de Flebotomíneos (FIOCRUZ/COLFLEB), Instituto René Rachou, Fundação Oswaldo Cruz, Av. Augusto de Lima, 1715, Barro Preto, Belo Horizonte, MG, Brasil, 30190-009..

Almost 30% of female American sand flies are morphologically indistinguishable from one another. These females belong to species-complexes or groups with closely related species, making species-level identification difficult or even impossible. This fact has implications for public health since several of these groups include species which are vectors of human pathogens. Read More

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October 2018

The association between dengue immunoglobulin G titres with previous clinical dengue infection and white cell counts in Cuban children: A population-based study.

PLoS One 2018 28;13(11):e0207391. Epub 2018 Nov 28.

Nottingham NIHR Biomedical Research Unit, Division of Epidemiology and Public Health, University of Nottingham, Clinical Sciences Building, City Hospital, Nottingham, United Kingdom.

Background: The prevalence of dengue infection is increasing globally. There are few prospective population-based surveillance studies of the immunological and inflammatory consequences of exposure to dengue virus in young children.

Objective: To study the association between serologically confirmed prior medical diagnosis of dengue infection and blood measures of systemic inflammation with dengue virus immunoglobulin G levels. Read More

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November 2018

Implication of violence against women on not performing the cytopathologic test.

Rev Saude Publica 2018 Nov 23;52:89. Epub 2018 Nov 23.

Universidade Federal de Pelotas. Departamento de Nutrição. Programa de Pós-Graduação em Epidemiologia. Pelotas, RS, Brasil.

Objective: To analyze the association between intimate partner violence and not performing the cytopathologic test in the last three years.

Methods: It is a transversal study, performed in 26 health units in the city of Vitória, state Espírito Santo, from march to September 2014. The sample was constituted by 106 primary care female users, aging from 30 to 59 years-old. Read More

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November 2018

Human visceral leishmaniasis and relationship with vector and canine control measures.

Rev Saude Publica 2018 Nov 23;52:92. Epub 2018 Nov 23.

Universidade de São Paulo. Faculdade de Saúde Pública. Departamento de Epidemiologia. São Paulo, SP, Brasil.

Objective: Estimate the coverage of control measures of visceral leishmaniasis and relate them with the occurrence of human visceral leishmaniasis in endemic urban area.

Methods: Cases of human and canine visceral leishmaniasis were considered as study population and evaluated by a serological survey conducted in Araçatuba, state São Paulo, from 2007 to 2015. The cases of human visceral leishmaniasis were geocoded by the address of the patients and the canine disease by the address of the dogs' owners. Read More

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November 2018

Association Between Maximal Oxygen Consumption and Physical Activity and Sedentary Lifestyle in Metabolic Syndrome. Usefulness of Questionnaires.

Rev Esp Cardiol (Engl Ed) 2018 Nov 24. Epub 2018 Nov 24.

Servicio de Cardiología, Organización Sanitaria Integrada (OSI) ARABA, Hospital Universitario Araba, Vitoria-Gasteiz, Álava, Spain; Centro de Investigación Biomédica en Red de la Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain; Departamento de Medicina, Unidad Docente de Medicina, Universidad del País Vasco/Euskal Herriko Univertsitatea (UPV/EHU), Vitoria-Gasteiz, Álava, Spain. Electronic address:

Introduction And Objectives: To analyze whether variations in physical activity (PA) and sedentary behaviors are accompanied by differences in maximal oxygen consumption (VO).

Methods: We conducted a prospective cross-sectional study of 243 participants (82 women), aged 65.0±4. Read More

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November 2018

Microinvasive breast carcinoma: An analysis from ten Senonetwork Italia breast centres.

Eur J Surg Oncol 2018 Oct 16. Epub 2018 Oct 16.

Breast Unit, San Giovanni-Addolorata Hospital, Rome, Italy. Electronic address:

Background And Objectives: We studied a large series of ductal carcinoma in situ with microinvasion (MIDC) an infrequent disease whose diagnosis and management are not well defined.

Methods: 17,431 cases of breast carcinoma were treated between 2011 and 2016 by ten Italian Breast Units. Our analysis included diagnostic and clinic-pathological characteristics, surgical management, and the use of adjuvant therapies. Read More

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October 2018
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Evaluation of the angle of the anterior chamber using ultrasound biomicroscopy, gonioscopy and a Van Herick examination.

Arch Soc Esp Oftalmol 2018 Nov 24. Epub 2018 Nov 24.

Ciencias de la Visión, Universidad El Bosque, Bogotá, Colombia; Epidemiología, Universidad El Bosque, Bogotá, Colombia. Electronic address:

Objective: To compare the measurement of the angle of the anterior chamber using ultrasound biomicroscopy (UBM), gonioscopy and the Van Herick examination.

Methods: An observational comparative study was carried out between 3different methods for the estimation of the iridocorneal angle. A total of 30 subjects with open and closed angles were evaluated using UBM, gonioscopy and Van Herick. Read More

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November 2018

[Heroine, but no Superwoman. Evaluation of a peer-training activity for women with breast cancer].

Gac Sanit 2018 Nov 24. Epub 2018 Nov 24.

CIBER de Epidemiología y Salud Pública (CIBERESP), España; Escuela Andaluza de Salud Pública, Granada, España; Instituto de Investigación Biosanitaria de Granada, Granada, España.

Objective: To evaluate a peer-training intervention for women with breast cancer, from a gender perspective: to discover the results of the intervention and examine in-depth the personal experiences of patients and health professionals participating in the training activity.

Method: Mixed method multicentre design completed in 2017 in Andalusia (Spain), with a pre and post evaluation questionnaire with 102 patients, measuring life style, limitations, use of health services, communication with professionals and self-management; and content analysis of semi-structured interviews and focus groups with 21 patient-trainers and 5 health professionals, looking at experiences, needs and suggestions for improvement.

Results: The patients described a good general health status, with improvements of: diet quality (7 in pre-test to 7. Read More

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November 2018

Influenza vaccination in health-care workers: Auctoritas and potestas.

Med Clin (Barc) 2018 Nov 24. Epub 2018 Nov 24.

Servicio de Medicina Preventiva y Epidemiologia, Hospital Clínic de Barcelona, Barcelona, España; Facultad de Medicina y Ciencias de la Salud, Universidad de Barcelona, Barcelona, España.

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November 2018

Arbovirus surveillance: first dengue virus detection in local mosquitoes in Europe, Catalonia, Spain, 2015.

Euro Surveill 2018 Nov;23(47)

IRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la Universitat Autònoma de Barcelona, Bellaterra, Spain.

Dengue has emerged as the most important viral mosquito-borne disease globally. The current risk of dengue outbreaks in Europe appeared with the introduction of the vector mosquito in Mediterranean countries. Considering the increasing frequency of dengue epidemics worldwide and the movement of viraemic hosts, it is expected that new autochthonous cases will occur in the future in Europe. Read More

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November 2018