9,926 results match your criteria Ephelides Freckles


Central nervous system magnetic resonance imaging abnormalities and neurologic outcomes in pediatric patients with congenital nevi: A 10-year multi-institutional retrospective study.

J Am Acad Dermatol 2022 Jun 15. Epub 2022 Jun 15.

Department of Dermatology, Massachusetts General Hospital, Boston, MA; Dermatology Program, Department of Allergy and Immunology, Boston Children's Hospital, Boston, MA; Harvard Medical School, Boston, MA.

Background: High-risk congenital melanocytic nevi (CMN) are associated with abnormalities of the central nervous system, prompting MRI screening guidelines.

Objective: Describe MRI brain and spine abnormalities in children with CMN and report trends between nevus features, MRI findings, and neurologic outcomes.

Methods: Retrospective review of individuals aged ≤ 18 years with an MRI of brain and/or spine and at least 1 dermatologist-diagnosed CMN. Read More

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Esophageal Melanocytosis: report of two cases and review of a rare and misunderstood entity.

Acta Gastroenterol Belg 2022 Apr-Jun;85(2):390-392

Department of Pathology, Institut de Pathologie et de Génétique, Gosselies, Belgium.

Esophageal melanocytosis (EM) is a rare entity, which is characterized by a non-atypical melanocytic proliferation and melanin deposits in the esophageal mucosa. The confusion between the terms of melanosis and melanocytosis in the literature, the rarity of this lesion (less than 50 cases reported in the literature), its uncertain pathobiological course and the lack of experience of pathologists and gastroenterologists prompt us to draw the attention to this particular entity by reporting two cases and reviewing the literature. Magnifying endoscopy to observe intensive melanin accumulation followed by a biopsy are key for the diagnosis. Read More

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Pigmentation Control in Pregnancy-Induced Melasma: Clinical Assessment of a Non-hydroquinone, Non-retinol Pigment-Correcting Serum.

J Cosmet Dermatol 2022 Jun 16. Epub 2022 Jun 16.

Allergan Aesthetics, an AbbVie Company, Irvine, CA, USA.

Background: Melasma is an acquired disorder that results in irregular brown patches on the skin that can occur due to hormonal changes. Although pregnancy-induced melasma is usually temporary, it can become a chronic condition, with significant negative impact on quality of life (QoL).

Aims: Determine the efficacy and tolerability of a topical, non-hydroquinone, non-retinol pigment-correcting serum (LYT2) for the treatment of pregnancy-induced melasma. Read More

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The effectiveness of tomato extract on superoxide dismutase (SOD) and severity degree of patients with melasma.

Ital J Dermatol Venerol 2022 Jun;157(3):262-269

Department of Dermatovenereology, Faculty of Medicine, Diponegoro University, Semarang, Indonesia.

Background: Melasma is present in 40% of cases in Southeast Asia. The condition is often unresponsive to therapy; treatment has variable success rates, and melasma has high recurrence rates. Lycopene-rich tomato extract is needed to avoid oxidative stress due to ultraviolet rays that cause melasma through the melanogenesis pathway. Read More

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Berardinelli-Seip Congenital Lipodystrophy - A Case Report and Review of Literature.

J Coll Physicians Surg Pak 2022 Jun;32(6):817-819

Department of Medicine, Fatima Memorial Hospital, College of Medicine and Dentistry, Lahore, Pakistan.

Berardinelli-Seip Congenital Lipodystrophy (BSCL), also known as congenital generalised lipodystrophy, is a genetic disorder where there is an absolute deficiency of adipose tissue. It affects the development of adipocytes and ultimately leads to an inability to store fat in adipocytes. It is extremely rare. Read More

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Endoscopic Therapy of Small Bowel Polyps by Single-Balloon Enteroscopy in Patients with Peutz-Jeghers Syndrome.

Int J Clin Pract 2022 1;2022:7849055. Epub 2022 Feb 1.

Department of Gastroenterology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, China.

Background: Little is known about the efficacy and safety of single-balloon enteroscopy (SBE) in patients with Peutz-Jeghers syndrome (PJS). The aim of this study was to assess the efficacy and safety of SBE for the treatment of small bowel polyps in patients with PJS.

Methods: We conducted a single-center observational study, which included all patients diagnosed with PJS who underwent SBE for polypectomy between January 2018 and March 2021. Read More

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Hydroxychloroquine induced melanosis.

Reumatol Clin (Engl Ed) 2022 Jun-Jul;18(6):377-378

Rheumatology Department, Centro Hospitalar de Vila Nova de Gaia e Espinho, Vila Nova de Gaia, Portugal.

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[The 495th case: young female-hyperandrogenemia-severe insulin resistance].

Zhonghua Nei Ke Za Zhi 2022 Jun;61(6):703-707

State Key Laboratory of Complex Severe and Rare Diseases, Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

A 22-year-old female has complained of hirsutism, acanthosis nigricans, enlarged clitoris, and menstrual disorders since puberty. Laboratory examinations revealed hyperandrogenemia. Severe insulin resistance and diabetes were found during hospitalization in our hospital. Read More

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Maintenance Outcomes of the Children's Healthy Living Program on Overweight, Obesity, and Acanthosis Nigricans Among Young Children in the US-Affiliated Pacific Region: A Randomized Clinical Trial.

JAMA Netw Open 2022 Jun 1;5(6):e2214802. Epub 2022 Jun 1.

Department of Human Nutrition, Food and Animal Sciences, College of Tropical Agriculture and Human Resources, University of Hawai'i at Mānoa, Honolulu.

Importance: Few obesity prevention trials among children have demonstrated sustainable outcomes in the long term.

Objectives: To sustain a community-wide decrease in the prevalence of overweight and obesity among young children in the US-affiliated Pacific region.

Design, Setting, And Participants: In the Children's Healthy Living community-randomized clinical trial, hierarchical modeling comparing the change in intervention and control communities accounted for community randomization (community clustering with jurisdictions), and adjusted for the age and sex distribution of the assessed children in a cross-sectional design. Read More

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Continuing Medical Education Questions: June 2022.

Authors:
Akwi W Asombang

Am J Gastroenterol 2022 Jun 17;117(6):844. Epub 2022 Feb 17.

Massachusetts General Hospital, Boston, Massachusetts.

Article Title: Diagnosis and Management of Cancer Risk in the Gastrointestinal Hamartomatous Polyposis Syndromes: Recommendations From the US Multi-Society Task Force on Colorectal Cancer. Read More

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Dermoscopy as an efficient aid to diagnose pigmentary and vascular component of periorbital melanosis: A cross-sectional study.

J Cosmet Dermatol 2022 Jun 4. Epub 2022 Jun 4.

Department of Dermatology, AIIMS, Raipur, India.

Introduction: Periorbital melanosis (POM) has a significant impact on quality of life. There is a dearth of literature regarding POM, especially in Asian population. Accurate classification of POM is contributory to the choice of therapy. Read More

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Melanosis coli: A factor not associated with histological progression of colorectal polyps.

J Dig Dis 2022 Jun 4. Epub 2022 Jun 4.

Department of Gastroenterology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.

Objective: The association of melanosis coli (MC) with increased colorectal polyp detection rate (PDR) is causal or simply because dark background making detection of polyps more easily remains to be studied. This retrospective study was conducted to research the association of MC with colorectal polyps.

Methods: 1104 MC patients with 2208 controls (matched by age, gender, bowel preparation quality) and 490 MC polyps with 980 controls (matched by age, gender, size and location of polyps) were enrolled. Read More

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Light Brown and Pink Macule on the Upper Arm.

Cutis 2022 02;109(2):87-97

HCA Healthcare/University of South Florida Morsani College of Medicine, Graduate Medical Education, Largo Medical Center.

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February 2022

A rare cause of mechanical intestinal obstruction due to small bowel intussusception: 'A solitary Peutz-Jeghers type hamartomatous polyp'.

Ulus Travma Acil Cerrahi Derg 2022 Jun;28(6):879-883

Department of General Surgery, Trakya University Faculty of Medicine, Edirne-Turkey.

Peutz-Jeghers Syndrome (PJS) is a rare autosomal dominant disorder which is characterized by hyperpigmentation in mucocutaneous membranes and hamartomatous polyps in the gastrointestinal tract (GIT). Common complications reported in patients with PSJ are bleeding and mechanical intestinal obstruction due to the hamartomatous polyps. There is also an increased risk of gastrointestinal and extra-intestinal malignancies in patients with PJS. Read More

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Topical Treatments for Melasma and Their Mechanism of Action.

J Clin Aesthet Dermatol 2022 May;15(5):19-28

Dr. González is with Mount Sinai Hospital in New York, New York.

Objective: We conducted a review of topical agents currently used in melasma, discussing their mechanism of action, efficacy, safety, and tolerability, with an update on newer treatments.

Methods: A systematic review from PubMed database was performed, using PRISMA guidelines. The search was limited to English and Spanish studies that were double or single blinded, prospective, controlled or randomized clinical trials, reviews of literature, and meta-analysis studies. Read More

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[Diagnostic utility of colonoscopy and histological evaluation in the study of patients with chronic diarrhea].

Rev Gastroenterol Peru 2021 Oct-Dec;41(4):221-226

Clínica Colsanitas. Bogotá, Colombia.

Introduction: Patients with chronic diarrhea often undergo colonoscopy evaluation, however, the performance of biopsies or ileoscopy remains controversial.

Objective: To evaluate the usefulness of colonoscopy plus biopsies in the study of patients with chronic diarrhea.

Materials And Methods: We retrospectively reviewed patients with chronic diarrhea who underwent colonoscopy between 2015 and 2019. Read More

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The peppered moth Biston betularia.

Curr Biol 2022 May;32(10):R447-R448

Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Henry Wellcome Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK. Electronic address:

Hannah Rowland and colleagues introduce the peppered moth whose industrial melanism was an early evidence for evolution. Read More

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Phlorotannins-bioactivity and extraction perspectives.

J Appl Phycol 2022 May 17:1-13. Epub 2022 May 17.

ICAR-Central Institute of Fisheries Technology (CIFT), Cochin-29, Cochin, India.

Phlorotannins, a seaweed based class of polyphenolic compounds, have proven to possess potential bioactivities such as antioxidant, antimicrobial, anti-allergic, anti-diabetic, anti-inflammatory, anti-cancerous, neuroprotection etc. These bioactivities have further increased demand globally and sustainable techniques such as supercritical fluid extraction, microwave assisted extraction, enzyme assisted extraction, extraction using deep eutectic solvents etc. are being explored currently for production of phlorotannin-rich extracts. Read More

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A Delphi consensus on the nomenclature and diagnosis of lichen planus pigmentosus and related entities.

Indian J Dermatol Venereol Leprol 2022 Apr 4:1-6. Epub 2022 Apr 4.

Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Background: Although well known in clinical practice, research in lichen planus pigmentosus and related dermal pigmentary diseases is restricted due to lack of consensus on nomenclature and disease definition.

Aims And Objectives: Delphi exercise to define and categorise acquired dermal pigmentary diseases.

Methods: Core areas were identified including disease definition, etiopathogenesis, risk factors, clinical features, diagnostic methods, treatment modalities and outcome measures. Read More

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[The role of metformin in the treatment of dermatological diseases: A narrative review].

Aten Primaria 2022 Jun 12;54(6):102354. Epub 2022 May 12.

Health Research Group GIIS100 of Health Research Institute IIS Aragón, Zaragoza, España; Servicio de Dermatología y Venereología, Hospital Clínico Universitario Miguel Servet, Zaragoza, España.

Objetive: To review and discuss the current evidence of the use of metformin as a therapeutic tool in frequent skin diseases.

Design: Original article. Qualitative research. Read More

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[A case of Peutz-Jeghers syndrome that developed triple cancers during the course].

Nihon Shokakibyo Gakkai Zasshi 2022 ;119(5):446-451

Department of Gastroenterology and Hepatology, Okayama University Hospital.

At the time of colon polyp follow-up, a 46-year-old Japanese woman with a history of invagination, colon polyps, cervical cancer, and breast cancer was suspected of Peutz-Jeghers syndrome and referred. Multiple polyposes of the jejunum were discovered by capsule endoscopy and double-balloon endoscopy, and the resected specimen was diagnosed with hamartoma. During the follow-up, advanced pancreatic cancer-derived from IPMN developed. Read More

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Lung cancer as a predominant feature in a patient with Peutz-Jeghers syndrome: Case report.

Thorac Cancer 2022 Jun 11;13(12):1862-1865. Epub 2022 May 11.

Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, Thessaloniki, Greece.

Peutz-Jeghers syndrome (PJS) is characterized by mucocutaneous pigmentation and gastrointestinal hamartomatous polyposis, which can lead to intussusception. PJS patients face high lifetime risks for various cancer types, with the majority of patients being diagnosed with tumors along the gastrointestinal tract. Herein, we present the case of a 34-year-old man who carried a germline STK11 pathogenic variant, while lacking the cardinal features of PJS syndrome. Read More

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Neurosurgical management of patients with neurocutaneous melanosis: a systematic review.

Neurosurg Focus 2022 05;52(5):E8

2Department of Neurological Surgery, Rutgers New Jersey Medical School, Newark, New Jersey.

Objective: Neurocutaneous melanocytosis (NCM), also referred to as neurocutaneous melanosis, is a rare neurocutaneous disorder characterized by excess melanocytic proliferation in the skin, leptomeninges, and cranial parenchyma. NCM most often presents in pediatric patients within the first 2 years of life and is associated with high mortality due to proliferation of melanocytes in the brain. Prognosis is poor, as patients typically die within 3 years of symptom onset. Read More

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Rapid quality deterioration of harpiosquillid mantis shrimp () during iced storage.

J Food Sci Technol 2022 May 9;59(5):1812-1822. Epub 2021 Jul 9.

International Center of Excellence in Seafood Science and Innovation, Faculty of Agro-Industry, Prince of Songkla University, Hat Yai, Songkhla, 90110 Thailand.

Changes in physicochemical, textural, microbial, and sensory quality of harpiosquillid mantis shrimp () (HMS) during 10 days of iced storage were studied. Weight and cooking losses were increased during storage (p < 0.05). Read More

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Application of the Kvaal method with cone beam for the determination of a local formula for the age estimation of adult African melanoderma subject, Côte d'Ivoire.

J Forensic Odontostomatol 2022 Apr 30;1(40):2-11. Epub 2022 Apr 30.

Department of Public Health and forensic odontology, UFR Odonto-Stomatologie, University of Félix Houphouët Boigny, Abidjan, Côte d'Ivoire.

Background: Age estimation by invasive dental methods is a destructive, costly and time-consuming approach, whereas, age estimation methods using dental radiographs are simple, non-destructive and provide reliable information. Age estimation by the Kvaal radiographic method has proven to be a reliable method, but possible ethnic variations may limit its uses in other populations. The objective of this study was to reproduce the original Kvaal method with CBCT for the estimation of the age of the adult melano-African subject in Côte d'Ivoire, in order to propose an age estimation formula, specific to our study population, by taking into account the measurements of tooth and pulp ratios. Read More

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Diagnosis and Management of Cancer Risk in the Gastrointestinal Hamartomatous Polyposis Syndromes: Recommendations From the US Multi-Society Task Force on Colorectal Cancer.

Gastroenterology 2022 Jun 26;162(7):2063-2085. Epub 2022 Apr 26.

Veterans Affairs Medical Center, White River Junction, Vermont; Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.

The gastrointestinal hamartomatous polyposis syndromes are rare, autosomal dominant disorders associated with an increased risk of benign and malignant intestinal and extraintestinal tumors. They include Peutz-Jeghers syndrome, juvenile polyposis syndrome, the PTEN hamartoma tumor syndrome (including Cowden's syndrome and Bannayan-Riley-Ruvalcaba syndrome), and hereditary mixed polyposis syndrome. Diagnoses are based on clinical criteria and, in some cases, confirmed by demonstrating the presence of a germline pathogenic variant. Read More

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Diagnosis and management of cancer risk in the gastrointestinal hamartomatous polyposis syndromes: recommendations from the U.S. Multi-Society Task Force on Colorectal Cancer.

Gastrointest Endosc 2022 Jun 26;95(6):1025-1047. Epub 2022 Apr 26.

Veterans Affairs Medical Center, White River Junction, Vermont; Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.

The gastrointestinal hamartomatous polyposis syndromes are rare, autosomal dominant disorders associated with an increased risk of benign and malignant intestinal and extraintestinal tumors. They include Peutz-Jeghers syndrome, juvenile polyposis syndrome, the PTEN hamartoma tumor syndrome (including Cowden's syndrome and Bannayan-Riley-Ruvalcaba syndrome), and hereditary mixed polyposis syndrome. Diagnoses are based on clinical criteria and, in some cases, confirmed by demonstrating the presence of a germline pathogenic variant. Read More

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