8,817 results match your criteria Ephelides Freckles


Effects of moringa leaves () extraction on quality changes and melanosis of giant freshwater prawn () during chilled storage.

Ital J Food Saf 2018 Sep 26;7(3):6846. Epub 2018 Sep 26.

Institute of Tropical Aquaculture.

An aqueous extraction of moringa () leaves were prepared as the edible coats for keeping the quality of the giant freshwater prawn (). In addition, the antioxidant properties and activity; total phenolic content (TPC), total flavonoid contents (TFC), free radical scavenging activity (DPPH), and ferric reducing antioxidant power (FRAP) of moringa leaves were also determined. The phenolic compounds and antioxidant properties in the moringa leaves are low; 16. Read More

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September 2018

Acquired diffuse slate-grey facial dyspigmentation due to henna: an unrecognized cause of pigment contact dermatitis in Korean patients.

Eur J Dermatol 2018 Oct;28(5):644-648

Department of Dermatology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Henna is a vegetable hair dye that can be used by individuals who are sensitized to oxidative dyes due to low allergenicity. The reported incidence of slate-grey facial dyspigmentation following the use of henna hair dye is extremely rare. This study aimed to identify the clinical, dermoscopic, and histopathological features of slate-grey facial dyspigmentation following the use of henna hair dye in Korean patients. Read More

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October 2018
4 Reads

Bilateral Iris Mammillations in Amblyopic Eyes without Oculodermal Melanocytosis or Neurofibromatosis.

Case Rep Ophthalmol Med 2018 29;2018:2534042. Epub 2018 Oct 29.

Department of Ophthalmology, Teikyo University School of Medicine, Tokyo 173-8605, Japan.

Purpose: Iris mammillations are related to oculodermal melanosis and iris nevi. We report a rare case of bilateral simple iris mammillations without ocular melanosis or systemic neuronal disorders.

Case Report: A healthy 10-year-old Japanese girl was found incidentally to have bilateral iris mammillations while being treated for amblyopia. Read More

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October 2018
1 Read

Clinicopathologically problematic melanocytic tumors: a case-based review.

Dermatol Pract Concept 2018 Oct 31;8(4):306-313. Epub 2018 Oct 31.

Anatomic Pathology Unit, Hospital of Macerata, Italy.

Background: In spite of recent advances in the histopathological and molecular diagnosis of melanocytic neoplasms, a certain proportion of these lesions remain a daunting challenge for both the clinician and the pathologist.

Objectives: To emphasize the importance of close collaboration between clinicians and pathologists in case of problematic melanocytic lesions.

Patients: We report and discuss 5 problematic scenarios of melanocytic lesions, including tumoral melanosis, nevoid melanoma, lentiginous melanoma, spitzoid melanoma and BAPoma that may pose diagnostic difficulties in our practice. Read More

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October 2018
1 Read

Going Viral 2019: Zika, Chikungunya, and Dengue.

Dermatol Clin 2019 Jan;37(1):95-105

Department of Dermatology, University Hospital "Dr. José E. González", Universidad Autónoma de Nuevo León, Mitras Centro, Avenida Gonzalitos y Madero S/N, Monterrey 64460, Mexico.

Chikungunya and Zika virus infections are emerging diseases in the Americas, and dengue continues to be the most prevalent arthropod-borne virus in the world. These arbovirus diseases may spread by endemic transmission or as travel-related infections and have rapidly expanded their geographic distribution secondary to vector spread. All 3 share a similar clinical picture that includes a maculopapular rash. Read More

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January 2019
14 Reads

A melanosis coli associated with a large flat adenoma of the cecum.

Clin Res Hepatol Gastroenterol 2018 Nov 14. Epub 2018 Nov 14.

Department of pathology, university hospital, 37044 Tours cedex 9, France.

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November 2018

Neurocutaneous Melanosis with Leptomeningeal Melanoma Involving Supratentorium and Infratentorium.

Cureus 2018 Sep 10;10(9):e3275. Epub 2018 Sep 10.

Radiotherapy, Christian Medical College, Vellore, IND.

Neurocutaneous melanoma is a rare congenital syndrome associated with congenital melanocytic nevi with meningeal melanosis or melanoma. The disease is aggressive and has a high propensity for leptomeningeal metastases. We present the case history of a man with neurocutaneous melanoma managed with radical excision followed by hypofractionated adjuvant radiotherapy. Read More

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September 2018
1 Read

Evaluation of the Prevalence of Oral Mucosal Lesions in a Population of Eastern Coast of South India.

J Int Soc Prev Community Dent 2018 Sep-Oct;8(5):396-401. Epub 2018 Oct 8.

Department of Public Health Dentistry, Sibar Institute of Dental Sciences and Research, Guntur, Andhra Pradesh, India.

Objective/aim: The aim of this study is to measure the association between oral mucosal lesions (OMLs) and habit of tobacco and alcohol in the population of Guntur city, Andhra Pradesh, South India.

Material And Method: A cross-sectional study was conducted on 300 participants in Guntur city with the habit of tobacco and alcohol consumption in various forms who were selected by stratified cluster random sampling technique. Guntur city was divided into four zones, that is, North, East, South, and West; and two administrative wards were randomly selected from each zone as clusters. Read More

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October 2018
3 Reads

Extensive Vulvar Melanosis.

Actas Dermosifiliogr 2018 Oct 31. Epub 2018 Oct 31.

Departamento de Dermatología, Hospital Costa del Sol, Marbella, Málaga, España.

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October 2018
1 Read

Diffuse palmoplantar keratotic papules and melanosis.

Int J Dermatol 2019 Jan 21;58(1):e9-e10. Epub 2018 Oct 21.

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

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January 2019
1 Read

A pilot study of oral tranexamic acid and Glycyrrhizin compound in the treatment of recalcitrant Riehl's melanosis.

J Cosmet Dermatol 2018 Oct 19. Epub 2018 Oct 19.

Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China.

Background: Up till now, there is no standardized and satisfactory treatment strategy for Riehl's melanosis.

Objective: In this pilot study, we evaluated the efficacy and safety of a novel combination therapy with oral administration of tranexamic acid (TA) and Glycyrrhizin compound for recalcitrant Riehl's melanosis.

Methods: Ten patients with Riehl's melanosis were recruited in this study. Read More

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October 2018
3 Reads

Tumoral melanosis associated with combined / inhibition (dabrafenib/trametinib) in metastatic melanoma.

JAAD Case Rep 2018 Oct 10;4(9):921-923. Epub 2018 Oct 10.

Dermatology Research Centre, The University of Queensland, The University of Queensland Diamantina Institute, Brisbane, Australia.

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October 2018
1 Read

A dermatoscopic portrait of morphological changes of vulvar melanosis over time.

J Dtsch Dermatol Ges 2018 Nov 9;16(11):1372-1375. Epub 2018 Oct 9.

Unit of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, Policlinico Sant'Orsola-Malpighi, University of Bologna, Italy.

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November 2018
1 Read
1.820 Impact Factor

Neurocutaneous Melanosis with Bilateral Temporal Lobe Lesions without Leptomeningeal Enhancement: A Distinct Entity or Subtype.

J Pediatr Neurosci 2018 Jul-Sep;13(3):331-333

Department of Radiology, Command Hospital (Central Command), Lucknow Cantonment, Lucknow, Uttar Pradesh, India.

Neurocutaneous melanosis (NCM) is a rare congenital disorder. Most of the cases described in literature for this entity have involvement of the leptomeninges and other structures of brain such as brain stem, temporal lobes, and spinal meninges and no involvement of leptomeninges and presence of lesions in bilateral temporal lobes. NCM without the involvement of leptomeninges should be considered a distinct entity as the prognosis is favorable as compared to cases with leptomeningeal involvement who develop early hydrocephalus and multiple cranial nerve palsies. Read More

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October 2018
2 Reads

[Primary melanoma of the bladder. A case report].

Rev Esp Patol 2018 Oct - Dec;51(4):244-247. Epub 2018 Feb 23.

Departamento de Patología, Hospital General San Juan de Dios, Guatemala, Guatemala.

Primary melanoma of the urinary bladder is rare. We report a case of a 58-year-old woman, who presented with a 4 month history of dysuria and hematuria. A biopsy indicated a diagnosis of invasive melanoma and a partial cystectomy was performed. Read More

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February 2018
2 Reads

Effect of layer-by-layer antimicrobial edible coating of alginate and chitosan with grapefruit seed extract for shelf-life extension of shrimp (Litopenaeus vannamei) stored at 4 °C.

Int J Biol Macromol 2018 Dec 26;120(Pt B):1468-1473. Epub 2018 Sep 26.

Department of Food and Nutrition, Kookmin University, Seoul 136-702, Republic of Korea. Electronic address:

The effect of a layer-by-layer (LbL) electrostatic deposition coating of alginate and chitosan with grapefruit seed extract was investigated on the shelf life of shrimp (Litopenaeus vannamei) stored for 15 days under refrigeration (4 °C). The shrimp were periodically analyzed for changes in microbiological parameters (total aerobic mesophilic bacteria and total aerobic psychrotrophic bacteria counts), chemical parameters, melanosis, and sensory characteristics. The chitosan-alginate coating had the advantage of reducing the bacterial count by 2 log CFU in combination with the antimicrobial activity of the grapefruit seed extract. Read More

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December 2018

Approach to Skin Lightening in Patients With Melasma.

Authors:
Philip R Cohen

J Drugs Dermatol 2018 Sep;17(9):1018

I read with interest the informative article by Spencer et al1 that describes the efficacious use as a novel skin lightening agent (LumaPro-C) for the treatment of patients with melasma. Read More

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September 2018
2 Reads

A Randomized, Double-Blind, Placebo-Controlled, Split-Face Study of the Efficacy of Topical Epidermal Growth Factor for the Treatment of Melasma.

J Drugs Dermatol 2018 Sep;17(9):970-973

Introduction: Melasma is a condition in which patients develop symmetric, reticulated, hyperpigmented macules and patches on the face which is thought to be the result of ultraviolet (UV) exposure and hormonal influences, although the pathogenesis is not completely understood. The topical application of epidermal growth factor has been used as a whitening agent, moisturizer, and an aid for wound healing. In this study, we explore the efficacy of topical EGF in the treatment of melasma. Read More

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September 2018
32 Reads

Unilateral retinoblastoma with contralateral isolated choroidal Melanocytosis: case report of an unexpected presentation.

BMC Ophthalmol 2018 Sep 17;18(1):251. Epub 2018 Sep 17.

Department of Ophthalmology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

Background: Congenital ocular melanocytosis has been shown to be extremely uncommon in studies of numerous infants and children with retinoblastoma and disorders such as retinopathy of prematurity.

Case Presentation: A 33-month-old Caucasian boy presented with a solid white predominantly endophytic retinoblastoma filling most of the nasal aspect of the fundus and extensive vitreous seeding. Fundus exam of the contralateral eye showed a broad-based flat melanotic area of the choroid extending from the subfoveal region to the ora serrata temporally. Read More

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September 2018
1 Read

The Largest Mass Poisoning in History: Arsenic Contamination of Well Water in Bangladesh.

Skinmed 2018 1;16(4):265-267. Epub 2018 Jul 1.

From the Department of Dermatology, SUNY Downstate Medical Center at Brooklyn, Brooklyn, New York, NY.

Arsenic is a naturally occurring compound that is widely distributed in trace quantities in the environment. Levels toxic to humans have been found contaminating certain regions of the world and their groundwater, leading to deleterious effects. In fact, an estimated 150 million people are affected by arsenic contamination worldwide. Read More

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Shunt Surgery for Neurocutaneous Melanosis with Hydrocephalus: Case Report and Review of the Literature.

World Neurosurg 2018 Dec 8;120:583-589.e3. Epub 2018 Sep 8.

Section of Neurosurgery, Department of Neurosciences, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Philippines. Electronic address:

Background: Neurocutaneous melanosis is a rare phakomatosis characterized by large or multiple pigmented nevi and melanosis of the leptomeninges. It is often complicated by hydrocephalus due to melanotic deposits interfering with cerebrospinal fluid reabsorption in the basal cisterns or causing foraminal or aqueductal obstruction. In 10% of cases, it will be associated with the Dandy-Walker complex. Read More

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December 2018
4 Reads

Tumoral Melanosis Arising on a Mycosis Fungoides Plaque

Balkan Med J 2018 11 11;35(6):447-448. Epub 2018 Sep 11.

Department of Pathology, Ankara University School of Medicine, Ankara, Turkey

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November 2018
5 Reads

A global consensus statement on ashy dermatosis, erythema dyschromicum perstans, lichen planus pigmentosus, idiopathic eruptive macular pigmentation, and Riehl's melanosis.

Int J Dermatol 2018 Sep 3. Epub 2018 Sep 3.

Department of Dermatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Ashy dermatosis (AD), lichen planus pigmentosus (LPP), erythema dyschromicum perstans (EDP), and idiopathic eruptive macular pigmentation are several acquired macular hyperpigmentation disorders of uncertain etiology described in literature. Most of the published studies on these disorders are not exactly comparable, as there are no clear definitions and different regions in the world describe similar conditions under different names. A consensus on the terminology of various morphologies of acquired macular pigmentation of uncertain etiology was a long-felt need. Read More

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September 2018
18 Reads
1.230 Impact Factor

Effect of Chamuang (Garcinia cowaRoxb.) leaf extract on inhibition of melanosis and quality changes of Pacific white shrimp during refrigerated storage.

Food Chem 2019 Jan 21;270:554-561. Epub 2018 Jul 21.

Department of Food Technology, Faculty of Agro-Industry, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand.

Inhibition of Pacific white shrimp polyphenoloxidase (PPO) with Chamuang leaf extract (CLE) was studied. CLE was rich in polyphenolic glycosides, in which chrysoeriol 6-C-glucoside-8-C-arabinopyranoside and 2-feruloyl-l-sinapoylgentiobiose were dominant. It also contained organic acids including hydroxycitric acid and oxalosuccinic acid. Read More

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January 2019
1 Read
3.391 Impact Factor

NRAS mutated diffuse leptomeningeal melanomatosis in an adult patient with a brief review of the so-called "forme fruste" of neurocutaneous melanosis.

Brain Tumor Pathol 2018 Oct 25;35(4):217-223. Epub 2018 Aug 25.

Pathology Unit, Department of Pathology and Diagnostics, University and Hospital Trust of Verona, Verona, Italy.

Primary melanocytic tumors of central nervous system represent rare tumors arising from melanocytes of the leptomeninges. These neoplasms include focal forms like melanocytoma and primary malignant melanoma and diffuse forms like leptomeningeal melanocytosis and primary leptomeningeal melanomatosis. The clinical diagnosis remains challenging, with clinical and radiologic features overlapping with other more common diseases. Read More

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October 2018
6 Reads

Primary Acquired Melanosis Treated with Combination Interferon and Retinoic Acid.

Ophthalmology 2018 Dec 17;125(12):1994-1996. Epub 2018 Aug 17.

Department of Ophthalmology, Prince of Wales, Randwick, Australia; Ophthalmic Surgeons, Randwick, Sydney, Australia; The University of New South Wales, Sydney, Australia.

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December 2018

Seborrheic melanosis and dermoscopy: Lumping better than splitting.

Indian J Dermatol Venereol Leprol 2018 Sep-Oct;84(5):585-587

First Department of Dermatology, Aristotle University, Thessaloniki, Greece.

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August 2018
1 Read

Comparable efficacy of adapalene 0.3% gel and tretinoin 0.05% cream as treatment for cutaneous photoaging.

Eur J Dermatol 2018 Jun;28(3):343-350

Associate professor, Department of Dermatology, FMB-Unesp, São Paulo Brazil.

Background: Adapalene has been previously evaluated as a treatment for actinic keratosis (AK) and solar lentigines and shown to improve signs of photoaging.

Objectives: To evaluate whether adapalene 0.3% gel is non-inferior to tretinoin 0. Read More

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June 2018
10 Reads

New insights into neurocutaneous melanosis.

Pediatr Radiol 2018 Nov 3;48(12):1786-1796. Epub 2018 Aug 3.

Neuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, 505 Parnassus Ave., San Francisco, CA, 94143-0628, USA.

Background: Neurocutaneous melanosis is a rare disorder in which children with large cutaneous melanotic nevi have associated melanosis in the brain. Although many affected children have structurally normal brains, some have associated developmental disorders or brain anomalies.

Objectives: To determine the range of extent of brain melanosis as assessed by magnetic resonance imaging (MRI) and to investigate the frequency and types of associated brain anomalies. Read More

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November 2018
3 Reads

Resolution of conjunctival melanoma with topical interferon alpha 2b in a patient with mitomycin C intolerance.

Arch Soc Esp Oftalmol 2018 Nov 30;93(11):558-561. Epub 2018 Jul 30.

Unidad de Oculoplástica, Hospital General, Granollers, España.

Objective: To describe the clinical and histological resolution of a case of an inexcisable conjunctival melanoma using topical interferon alpha 2b (INFα2b) in a patient with mitomycin C (MMC) intolerance.

Case Report: Conjunctival melanoma is a rare, but potentially sight- and life-threatening, tumour. In cases of multiple lesions, or when surgical excision is not possible, topical combination chemotherapy with MMC and INFα2b has been described as first line therapy. Read More

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November 2018
1 Read

Malignant Acanthosis nigricans associated with early diagnosis of liver cancer.

An Bras Dermatol 2018 Jul-Aug;93(4):616-617

Discipline of Dermatology, Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto (SP), Brazil.

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August 2018
5 Reads

A Study of Clinicopathological Correlation of Periorbital Hyperpigmentation.

Indian Dermatol Online J 2018 Jul-Aug;9(4):245-249

Department of Dermatology, T. N. M. C. and B.Y.L. Nair Ch. Hospital, Mumbai, Maharashtra, India.

Context: "Dark circles" are esthetic concerns that can affect individuals of any age, gender, or race. They can be familial, physiological, or associated with various medical illnesses.

Aim: To study the clinicopathological correlation of periorbital hyperpigmentation. Read More

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LKB1 deficiency in T cells promotes the development of gastrointestinal polyposis.

Science 2018 07;361(6400):406-411

Goodman Cancer Research Centre, McGill University, Montreal, Quebec H3A 1A3, Canada.

Germline mutations in , which encodes the tumor suppressor liver kinase B1 (LKB1), promote Peutz-Jeghers syndrome (PJS), a cancer predisposition syndrome characterized by the development of gastrointestinal (GI) polyps. Here, we report that heterozygous deletion of in T cells (LT mice) is sufficient to promote GI polyposis. Polyps from LT mice, mice, and human PJS patients display hallmarks of chronic inflammation, marked by inflammatory immune-cell infiltration, signal transducer and activator of transcription 3 (STAT3) activation, and increased expression of inflammatory factors associated with cancer progression [interleukin 6 (IL-6), IL-11, and CXCL2]. Read More

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July 2018
1 Read

A Sweet Discovery.

Gastroenterology 2018 11 19;155(5):e13-e14. Epub 2018 Jul 19.

Endoscopy Unit, Department of Upper Abdominal Diseases, Karolinska University Hospital & Karolinska Institute, Stockholm, Sweden.

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November 2018
2 Reads

Optimizing q-switched lasers for melasma and acquired dermal melanoses.

Indian J Dermatol Venereol Leprol 2018 Jul 16. Epub 2018 Jul 16.

Department of Dermatology, Skin and Laser Clinic, Hyderabad, Telangana, India.

The Q-switched Nd:YAG laser is an established modality of treatment for epidermal and dermal pigmented lesions. The dual wavelengths of 1064nm and 532nm are suited for the darker skin tones encountered in India. Though this laser has become the one of choice for conditions such as nevus of Ota, Hori's nevus and tattoos, its role in the management of melasma and other acquired dermal melanoses is not clear. Read More

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July 2018
2 Reads

Port-wine stain as a clue for two rare coexisting entities.

BMJ Case Rep 2018 Jul 13;2018. Epub 2018 Jul 13.

Department of Dermatovenereology, Hospital de Braga, Braga, Portugal.

Phakomatosis pigmentovascularis (PPV) is an uncommon dermatosis characterised by the presence of both pigmentary and vascular abnormalities. Its pathogenesis is not elucidated, and the prognosis is mainly determined by the presence of extracutaneous manifestations, such as Klippel-Trenaunay syndrome (KTS), that is defined by the triad of a port-wine stain (PWS), anomalous veins and progressive overgrowth of the affected extremity. Herein, we report a case of an adult patient, who presented with a large PWS, nevus of Ota, ocular melanosis, and limb hypertrophy and varicosities. Read More

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July 2018
3 Reads

Aggressive melanoma in an infant with congenital melanocytic nevus syndrome and multiple, NRAS and BRAF mutation-negative nodules.

Pediatr Dermatol 2018 Sep 12;35(5):e281-e285. Epub 2018 Jul 12.

Faculty of Medicine, University of Oslo, Oslo, Norway.

We report the case of a newborn boy with multinodular NRAS and BRAF mutation-negative congenital melanocytic nevi and cerebral lesions compatible with congenital intraparenchymal melanosis. Histopathology from skin lesions showed atypical nodular melanocytic proliferation with marked melanocytic atypia and a large number of mitoses and apoptosis, indicating aggressive proliferation. The child developed several new subcutaneous tumors and multiple internal lesions, which were confirmed to be metastases, and died at 5 months of age. Read More

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September 2018
9 Reads

The Dual PI3K/mToR Inhibitor Omipalisib/GSK2126458 Inhibits Clonogenic Growth in Oncogenically-transformed Cells from Neurocutaneous Melanocytosis.

Cancer Genomics Proteomics 2018 Jul-Aug;15(4):239-248

Department of Pathology, Children's Hospital of Pittsburgh, Pittsburgh, PA, U.S.A.

Background: Omipalisib has been found to affect the viability of cancer cells. However, its effect on clonogenicity - a feature of cancer stem cells, is not clear. Cells isolated from neurocutaneous melanocytosis (NCM) patients' lesions grow clonogenically. Read More

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November 2018
3 Reads
1.862 Impact Factor

Diagnostic features of acquired dermal melanocytosis of the face and extremities.

Clin Exp Dermatol 2018 Oct 27;43(7):806-809. Epub 2018 Jun 27.

Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

Acquired dermal melanocytosis of the face and extremities (ADMFE) is an unusual form of acquired dermal melanocytosis (ADM). In this paper, we report a case of ADMFE and review the published literature. Our review highlights several clinical differences between ADMFE and ADM: (i) more frequent involvement of the nasal alae in ADMFE than in ADM, (ii) less frequent involvement of the cheeks in ADMFE than in ADM, (iii) limbs affected in all cases of ADMFE but in few cases of ADM, and (iv) frequent involvement of conjunctiva and/or gingiva in ADMFE but very rare involvement in ADM. Read More

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October 2018
1 Read

Neurocutaneous melanosis presenting with hydrocephalus and malignant transformation: case-based update.

Childs Nerv Syst 2018 Aug 12;34(8):1471-1477. Epub 2018 Jun 12.

University Hospital of Wales, Cardiff, UK.

Introduction: Neurocutaneous melanosis (NCM) is a sporadic condition characterised by congenital melanocytic nevi and melanocytic thickening of the leptomeninges. It is believed to result from congenital dysplasia of melanin-producing cells within the skin and leptomeninges. The management of cutaneous manifestations remains controversial; for neurological manifestations, outcome remains poor even with the use of radiotherapy and chemotherapy. Read More

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August 2018
6 Reads

Pigmented lesions of the oral mucosa: A cross-sectional study of 458 histopathological specimens.

Oral Dis 2018 Nov 10;24(8):1484-1491. Epub 2018 Jul 10.

Department of Oral Pathology and Surgery, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Objectives: To evaluate clinical, demographic, and histopathological characteristics of pigmented lesions of the oral mucosa.

Materials And Methods: A cross-sectional study was conducted over a 64-year period. Information was collected from medical charts, and all archived histopathological specimens with diagnoses of any pigmented lesion were retrieved. Read More

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November 2018
2 Reads

Cutaneous manifestations in Egyptian children with beta-thalassemia major: Relationship with serum ferritin, thyroid profile, and treatment modalities.

Pediatr Dermatol 2018 Sep 26;35(5):639-643. Epub 2018 Jun 26.

Departments of Dermatology, Venereology, and STDs, Faculty of Medicine, Fayoum University, Fayoum, Egypt.

Background: Cutaneous manifestations can be found in many patients with hematologic disorders, including thalassemia.

Methods: Patients with beta-thalassemia major attending the pediatric department of Fayoum University Hospital from April 2016 to October 2016 (n = 100) were compared with controls (n = 100). Both groups underwent detailed history evaluation, clinical examination, and laboratory investigations, including complete blood count, liver and kidney function, serum ferritin, and thyroid profile. Read More

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September 2018

Giant congenital melanocytic nevus in a Cameroonian child: a case report.

J Med Case Rep 2018 Jun 23;12(1):175. Epub 2018 Jun 23.

Department of Internal Medicine and Sub-specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon.

Background: Giant congenital melanocytic nevus is a very rare condition characterized by a large skin lesion and an increased risk of complications like neurocutaneous melanosis and malignant transformation. Reports of giant congenital melanocytic nevus are scarce in the sub-Saharan African literature and here we present a case of this disease in a Cameroonian adolescent.

Case Presentation: A 12-year-old Cameroonian girl from the "Baka" ethnic group, with no relevant family and medical histories presented with a progressively extensive brownish-black nodular hypertrophic skin lesion of approximately 45 cm, which she had had since she was 2-days old. Read More

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June 2018
9 Reads

Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.

J Periodontol 2018 Jun;89 Suppl 1:S74-S84

Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Japan.

Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i. Read More

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June 2018
27 Reads

Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.

J Clin Periodontol 2018 Jun;45 Suppl 20:S68-S77

Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Japan.

Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i. Read More

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June 2018
46 Reads

Granulomatous Tumoral Melanosis Associated With Pembrolizumab Therapy: A Mimicker of Disease Progression in Metastatic Melanoma.

Am J Dermatopathol 2018 Jul;40(7):523-526

Department of Pathology and Laboratory Medicine, University of Calgary and Calgary Laboratory Services, Calgary, Alberta, Canada.

Immune checkpoint inhibitor therapy has revolutionized the treatment of advanced melanoma, with these agents significantly improving survival for patients with metastatic disease. With the increasing use of these agents, the number of adverse reactions secondary to their use has also increased. Sarcoidosis and sarcoid-like reactions are one such immune checkpoint inhibitor-related adverse event. Read More

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July 2018
14 Reads

Development and validation of a multidimensional questionnaire for evaluating quality of life in melasma (HRQ-melasma).

An Bras Dermatol 2018 Jun;93(3):391-396

Department of Dermatology, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu, SP, Brazil.

Background: Melasma has a major impact on quality of life. MELASQoL is the only validated specific psychometric instrument to evaluate melasma QoL.

Objective: To develop and validate a multidimensional questionnaire for evaluating quality of life related to facial melasma. Read More

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June 2018
9 Reads

A novel STK11 missense mutation (c.346G > T) causing Peutz-Jeghers syndrome in a Chinese male with a negative family history.

Dig Liver Dis 2018 08 4;50(8):864-866. Epub 2018 Jun 4.

Department of Gastroenterology, Airforce General Hospital of PLA, Beijing, China. Electronic address:

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August 2018
1 Read

Evaluation of large clinically atypical vulvar pigmentation with RCM: atypical melanosis or early melanoma?

J Eur Acad Dermatol Venereol 2018 Jun 19. Epub 2018 Jun 19.

Dermatology Department, Centre Hospitalier de Lyon Sud, Hospices civils de Lyon, Université Claude Bernard Lyon 1, Pierre Bénite, France.

Background: Vulvar melanosis can occasionally be clinically challenging by mimicking an early melanoma.

Objective: To report our experience of initial evaluation and follow-up in this peculiar subset of vulvar melanosis using reflectance confocal microscopy (RCM).

Methods: We retrospectively evaluated 18 consecutive cases referred for atypical vulvar pigmentation or for which melanoma was considered and that underwent both RCM examination and histopathological assessment. Read More

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June 2018
11 Reads