9,550 results match your criteria Ephelides Freckles


Carvacrol, citral and α-terpineol essential oil incorporated biodegradable films for functional active packaging of Pacific white shrimp.

Food Chem 2021 May 30;363:130252. Epub 2021 May 30.

Department of Packaging and Materials Technology, Faculty of Agro-Industry, Kasetsart University, 50 Ngam Wong Wan Rd., Latyao, Chatuchak, Bangkok 10900, Thailand; Center for Advanced Studies for Agriculture and Food, Kasetsart University, 50 Ngam Wong Wan Rd., Latyao, Chatuchak, Bangkok 10900, Thailand. Electronic address:

Biodegradable poly(butylene adipate terephthalate) and poly(lactic acid) (PBAT/PLA) blend films compounded with carvacrol, citral and α-terpineol essential oils (EOs) were produced for food packaging via blown-film extrusion. PBAT/PLA interacted with citral and α-terpineol via hydrogen bonding and carbonyl groups. Microstructures and barrier properties against water vapor and oxygen were modified depending on types and concentrations (3% and 6%) of EOs. Read More

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Case of Rapidly Expanding Conjunctival Malignant Melanoma Initially from Primary Acquired Melanosis Diagnosed 14 Years Earlier.

Int Med Case Rep J 2021 28;14:361-364. Epub 2021 May 28.

Department of Ophthalmology, Nara Medical University, Nara, Japan.

Primary acquired melanosis (PAM) of the conjunctiva is a potentially serious melanocytic lesion that can lead to the development of a melanoma. A 60-year-old woman noticed pigmentation of the conjunctiva of her left eye for more than 10 years. She underwent excisional biopsy combined with cryotherapy and was diagnosed with PAM without atypia by intraoperative consultation. Read More

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PRAME Immunohistochemistry is Useful in the Evaluation of Conjunctival Melanomas, Nevi, and Primary Acquired Melanosis.

J Cutan Pathol 2021 Jun 4. Epub 2021 Jun 4.

Department of Surgery, Section of Ophthalmology, Geisel School of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.

Background: Many dermatopathologists find conjunctival melanocytic proliferations challenging because they are rare relative to their cutaneous counterparts and have nuanced morphology and nomenclature. PRAME immunohistochemistry has been widely adopted for distinguishing cutaneous nevi from melanoma, but limited data exist assessing its utility in evaluating conjunctival specimens. In particular, it is uncertain whether it can predict the risk of melanoma progression in primary acquired melanosis (PAM). Read More

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Inhibitory Effect of Olive Phenolic Compounds Isolated from Olive Oil By-Product on Melanosis of Shrimps.

Antioxidants (Basel) 2021 May 5;10(5). Epub 2021 May 5.

Department of Food Phytochemistry, Instituto de la Grasa (Spanish National Research Council, CSIC), Pablo Olavide University, Building 46, Ctra de Utrera km 1, 41013 Seville, Spain.

Melanosis is an unsolved problem of the crustacean industry and the cause of great loss of value. This study investigates the effect of two potent, natural antioxidants isolated from olive waste (hydroxytyrosol, HT and 3,4-dihydroxyphenylglycol, DHPG) and three novel HT-derivatives containing selenium and sulfur (dihydroxytyrosyl diselenide, -hydroxytyrosyl selenourea, and -hydroxytyrosyl thiourea) on the prevention of melanosis in Atlantic ditch shrimp () during refrigerated storage. These results clearly demonstrate the positive inhibitory effect of DHPG and dihydroxytyrosyl diselenide on delaying melanosis in vivo, although this effect was not dose dependent. Read More

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Cutaneous Manifestations of Diabetes.

Med Clin North Am 2021 Jul;105(4):681-697

Department of Dermatology, Mayo Clinic, Rochester, MN, USA. Electronic address:

Diabetes mellitus is a significant worldwide health concern and cutaneous manifestations are common. This review describes characteristic skin findings of diabetes, general skin findings related to diabetes, and findings related to diabetes treatment with a focus on clinical presentation, diagnosis, pathophysiology, epidemiology, and treatment. As the prevalence of diabetes continues to rise, cutaneous manifestations of diabetes mellitus likely will be encountered more frequently by physicians in all disciplines including dermatologists and primary care physicians. Read More

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Imaging and clinical features of neurocutaneous melanosis in the pediatric population.

Curr Med Imaging 2021 05 26. Epub 2021 May 26.

Department of Biomedical and Dental Sciences and of Morphofunctional Imaging, University of Messina, Italy.

Background: Neurocutaneous melanosis (NCM) is a rare nonfamilial phakomatosis characterized by the presence of congenital melanocytic nevi and abnormal melanocytes infiltration of the leptomeninges.

Objective & Methods: This paper shows the importance of early diagnosis and the most important imaging features of the disease on CT and MR scans. PubMed database was searched from January 1972 to September 2020. Read More

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Use of Hyaluronic acid fillers in treatment of peri ocular melanosis induced by shadow effect of tear trough deformity: Anatomical considerations, patient satisfaction and management of complications.

J Cosmet Dermatol 2021 May 24. Epub 2021 May 24.

Department of Dermatology and STD, VMMC and Safdarjung Hospital, Delhi, India.

Background: Periocular melanosis (POM) due to shadow effect of tear trough deformity (TT )does not respond to the conventional treatment modalities. Hyaluronic acid(HA) fillers are a favourable treatment modality . This area is a high-risk for injectables due to its unique anatomy . Read More

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Giant cerebriform melanocytic nevus of the scalp: A case report.

Clin Case Rep 2021 May 5;9(5):e03807. Epub 2021 May 5.

School of Medicine Isfahan University of Medical Sciences Isfahan Iran.

Giant melanocytic nevus is a rare condition caused by benign proliferation of melanocytes. There is a slight risk of malignancy in these lesions which should be noticed especially when they become larger. GCMN can be removed by plastic surgery. Read More

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Bilateral idiopathic choroidal hyperpigmentation.

Eur J Ophthalmol 2021 May 20:11206721211019573. Epub 2021 May 20.

Medical Retina and Vitreoretinal Surgery, University of Pittsburgh School of Medicine, Pittsburg, PA, USA.

Purpose: To report a series of cases showing bilateral circumpapillary hyperpigmentation on routine fundus examination.

Methods: In this observational case series, three patients showing bilateral circumpapillary hyperpigmentation on routine fundus examination were included. Multimodal retinal imaging was done for these cases. Read More

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Clinical and Histopathological Features of Corneal Primary Acquired Melanosis and Melanoma.

Ocul Oncol Pathol 2021 Mar 21;7(2):103-107. Epub 2021 Jan 21.

Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA.

Aim: The aim of this study is to describe the clinical and pathologic features of corneal primary acquired melanosis (PAM) and melanoma.

Methods: We describe 3 cases in total: two cases of corneal melanomas and 1 case of corneal PAM. The eyes were processed routinely for histopathological examination. Read More

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Assessment of Patients with Periorbital Melanosis for Hyperinsulinemia and Insulin Resistance.

Indian Dermatol Online J 2021 Mar-Apr;12(2):244-249. Epub 2021 Mar 2.

Department of Dermatology, Jawaharlal Institute of Post Graduate Medical Education and Research, Puducherry, India.

Background: Periorbital melanosis (PM) is one of the most common dermatological condition seen in routine practice. Several cutaneous markers such as acanthosis nigricans have been associated with insulin resistance (IR). However, the association of PM with IR needs to be substantiated. Read More

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Cerebellar amelanotic melanoma can mimic cerebellar abscess in a pediatric case of neurocutaneous melanosis.

Clin Case Rep 2021 Apr 12;9(4):1999-2006. Epub 2021 Feb 12.

Department of Biomedical and Dental Sciences and of Morphofunctional Imaging University of Messina Messina Italy.

Neurocutaneous melanosis (NCM) is a rare phakomatosis that may be associated with intracerebral masses. The differential diagnosis of intracerebral masses in NCM is often challenging and should include pigmented and nonpigmented lesions. Read More

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Inhibition of β-Catenin Activity Abolishes LKB1 Loss-Driven Pancreatic Cystadenoma in Mice.

Int J Mol Sci 2021 Apr 28;22(9). Epub 2021 Apr 28.

Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung 804, Taiwan.

Pancreatic cancer (PC) is the seventh leading cause of cancer death worldwide, and remains one of our most recalcitrant and dismal diseases. In contrast to many other malignancies, there has not been a significant improvement in patient survival over the past decade. Despite advances in our understanding of the genetic alterations associated with this disease, an incomplete understanding of the underlying biology and lack of suitable animal models have hampered efforts to develop more effective therapies. Read More

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Novel Insights into Diagnosis, Biology and Treatment of Primary Diffuse Leptomeningeal Melanomatosis.

J Pers Med 2021 Apr 12;11(4). Epub 2021 Apr 12.

Department of Pediatrics and Adolescent Medicine and Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria.

Primary diffuse leptomeningeal melanomatosis (PDLMM) is an extremely rare and aggressive cancer type for which best treatment strategies remain to be elucidated. Herein, we present current and prospective diagnostic strategies and treatment management of PDLMM. Against the background of an extensive literature review of published PDLMM cases and currently employed therapeutic strategies, we present an illustrative case of a pediatric patient suffering from PDLMM. Read More

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Melanocyte Colonization and Pigmentation of Breast Carcinoma: Description of Two Pathological Cases and Review of Literature.

Diagnostics (Basel) 2021 Apr 15;11(4). Epub 2021 Apr 15.

Unità di Ginecopatologia e Patologia Mammaria, Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli 8, 00168 Roma, Italy.

Colonization of breast carcinoma by non-neoplastic melanocytes of epidermal origin was first described by Azzopardi and Eusebi in 1977. We herein report two cases on the exceptional clinical and pathological features of this phenomenon in a 66-year-old and a 51-year-old patients. The pathogenesis is not fully understood, but a disrupted basement membrane and the role of tumoral growth factors are considered essential. Read More

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Exploratory Study of Epidermis, Basement Membrane Zone, Upper Dermis Alterations and Wnt Pathway Activation in Melasma Compared to Adjacent and Retroauricular Skin.

Ann Dermatol 2020 Apr 11;32(2):101-108. Epub 2020 Mar 11.

Department of Dermatology and Radioterapy, Botucatu School of Medicine, São Paulo State University, Botucatu, Brazil.

Background: Melasma is a chronic acquired focal hypermelanosis which pathogenesis has not been fully elucidated. Classical pathophysiologic studies have analysed the affected and perilesional areas, but little is known about the status of sun-protected skin, which is subjected to the same endogenous and genetic factors.

Objective: To assess the histological characteristics of melasma compared to adjacent and retroauricular skin. Read More

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The Role of Patch Testing with Indian Cosmetic Series in Patients with Facial Pigmented Contact Dermatitis in India.

Indian J Dermatol 2021 Jan-Feb;66(1):81-86

Department of Dermatology, Calcutta National Medical College, Kolkata, West Bengal, India.

Background: Pigmented contact dermatitis (PCD) is a non-eczematoid variant of contact dermatitis, mainly characterised by hyperpigmentation. It occurs due to contact with a low amount of allergen over a long duration of time. PCD is frequently seen in Indians but is often misdiagnosed or underdiagnosed because of the asymptomatic nature of the entity. Read More

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Adopting low-shot deep learning for the detection of conjunctival melanoma using ocular surface images.

Comput Methods Programs Biomed 2021 Jun 3;205:106086. Epub 2021 Apr 3.

B&VIIT Eye Center, Seoul, South Korea; VISUWORKS, Seoul, South Korea.

Background And Objective: The purpose of the present study was to investigate low-shot deep learning models applied to conjunctival melanoma detection using a small dataset with ocular surface images.

Methods: A dataset was composed of anonymized images of four classes; conjunctival melanoma (136), nevus or melanosis (93), pterygium (75), and normal conjunctiva (94). Before training involving conventional deep learning models, two generative adversarial networks (GANs) were constructed to augment the training dataset for low-shot learning. Read More

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The Histogenetic Model of Melanoma in the Modern Era of Personalized Medicine.

Acta Dermatovenerol Croat 2020 Dec;28(7):236-237

Prof. Luca Roncati, MD, DMLS, PhD , Polyclinic Hospital, Largo del Pozzo 71 - 41124 , Modena (MO), Italy;

Malignant melanoma (M) can be defined, quite simply, as a malignant neoplasm derived from melanocytes; however, there is great histological and, consequently, clinical variability from case to case (1). In order to try to overcome this intrinsic difficulty, various classification systems have been proposed over the years; as part of this effort, the World Health Organization (WHO) introduced its famous classification about half a century ago (2). Currently, the International Classification of Diseases for Oncology (ICD-O), provided by the WHO International Agency for Research on Cancer (IARC), distinguishes the in situ forms from invasive ones, recognizing four main morphological subtypes: nodular M, superficial spreading M, lentigo maligna M, and acral lentiginous M (3). Read More

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December 2020

Histopathological Variability and Concomitant Lesions in Pterygium in a Large Case Series.

J Ophthalmol 2021 19;2021:6623794. Epub 2021 Mar 19.

The MUHC-McGill University Ocular Pathology & Translational Research Laboratory, McGill University, Montreal, Quebec, Canada.

Pterygium is a common lesion consisting of fleshy conjunctival growth extending towards the cornea. There is no documented risk of malignant transformation; however, concomitant disease is not rare, and its link to sunlight exposure indicates a risk of other malignancies. The purpose of our study is to describe histopathological features of resected pterygiums and to recognize patients at risk of other conjunctival diseases. Read More

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Video image of genital melanosis provides strong evidence to support identification of a sexual offender.

Forensic Sci Med Pathol 2021 Apr 5. Epub 2021 Apr 5.

Department of Legal Medicine, Kyorin University School of Medicine, Tokyo, Japan.

A man in his thirties was suspected of committing a sexual offense against a young girl. A video on his mobile telephone provided the only evidence. Photographs obtained from the video showed male genitalia in two views, with the penis in both views exhibiting unique pigmentation. Read More

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Halophytes as a potential source of melanosis-inhibiting compounds. Mechanism of inhibition of a characterized polyphenol extract of purslane (Portulaca oleracea).

Food Chem 2021 Sep 23;355:129649. Epub 2021 Mar 23.

Institute of Food Science, Technology and Nutrition (CSIC), 10 José Antonio Novais St, 28040 Madrid, Spain. Electronic address:

The market value of crustaceans depreciates during storage due to the appearance of melanosis caused by polyphenol oxidases. Sulfite derivatives are used as melanosis-inhibiting agents, but their unhealthy effects make it preferable to replace them with natural preservatives. In this work, a crude enzymatic extract from whiteleg shrimp (Penaeus vannamei) was characterized and used to test the diphenol oxidase-inhibiting activity of polyphenol extracts of five underutilized halophyte plants, namely crystalline ice plant, seaside arrowgrass, purslane, sea fennel, and seashore aster. Read More

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September 2021

Intestinal obstruction with oral pigmentation: a clue to Peutz-Jeghers syndrome.

BMJ Case Rep 2021 Apr 1;14(4). Epub 2021 Apr 1.

General Surgery, All India Institute of Medical Sciences, Bhubaneswar, India.

Peutz-Jeghers syndrome (PJS) is an autosomal dominant disorder, which manifests as mucocutaneous hyperpigmentation and, intestinal and extraintestinal polyps. The classic triad of abdominal pain, mass and jam-like stools are not found commonly. On clinical examination, a strong suspicion of PJS should be made if patients below 18 years, present with mucocutaneous hyperpigmentation and intestinal obstruction. Read More

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Conjunctival melanoma: outcomes based on tumour origin in 629 patients at a single ocular oncology centre.

Eye (Lond) 2021 Mar 26. Epub 2021 Mar 26.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.

Purpose: To investigate clinical features and outcomes of conjunctival melanoma classified by tumour origin.

Methods: Retrospective review of conjunctival melanoma patients at a single ocular oncology centre between April 18, 1974 and September 9, 2019. Lesions were divided into three tumour origin groups (primary acquired melanosis [PAM], nevus, and de novo) and clinical features and outcomes were compared. Read More

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[Melanocytic Tumors].

No Shinkei Geka 2021 Mar;49(2):389-394

Department of Translational Research, Brain Research Institute, Niigata University.

Primary melanocytic neoplasms of the central nervous system(CNS)presumably arise from leptomeningeal melanocytes that are derived from the neural crest. Melanocytic neoplasms associated with neurocutaneous melanosis likely derive from melanocyte precursor cells that reach the CNS after somatic mutations, mostly, of the . They should be distinguished from other melanotic tumors involving the CNS, including metastatic melanoma and other primary tumors that undergo melanization, such as melanocytic schwannomas, medulloblastomas, paragangliomas, and various gliomas, because these lesions require different patient workups and therapy. Read More

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Acinar Melanosis of the Bartholin Gland: A Report of 3 Cases.

Int J Gynecol Pathol 2021 Mar 15. Epub 2021 Mar 15.

Scripps Memorial Hospital, Encinitas (K.M.K.) Scripps Memorial Hospital, La Jolla (L.C.) Scripps Clinic Pathology, La Jolla (P.M.G.), California Department of Paediatrics, Monash University (A.M.) Monash Pathology, Monash Medical Centre (A.M., B.K.), Clayton, Victoria, Australia.

Melanocytic pigmentation occurs in multiple sites in the lower female genital tract, but is rare within benign cysts of the vulva. We report 3 patients with multiloculated cystic lesions of the vulvar vestibule exhibiting prominent melanocytic pigmentation. The current cases differ from a previous report of melanosis in a Bartholin gland cyst in that the population of melanocytes occupies the acinar structures of the gland, rather than a squamous-lined surface. Read More

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Non-Peutz-Jeghers syndrome-associated ovarian sex cord tumor with annular tubules treated by radiotherapy: a case report and literature review.

J Int Med Res 2021 Mar;49(3):300060521996563

Department of Radiation Oncology, The First Hospital of Jilin University, Changchun, China.

There are no standard treatment options for metastatic and recurrent non-Peutz-Jeghers syndrome (PJS)-associated sex cord tumor with annular tubules (SCTAT). The effects of chemotherapy and/or radiotherapy are still not well-defined. Herein, we present a case of a metastatic and recurrent non-PJS-associated SCTAT showing high serum estradiol and progesterone concentrations after surgery and chemotherapy. Read More

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Appendiceal intussusception secondary to hamartomatous polyps of Peutz-Jegher syndrome.

ANZ J Surg 2020 10;90(10):2144-2145

Department of Colorectal Surgery, Royal North Shore Hospital, Sydney, New South Wales, Australia.

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October 2020