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    1 OF 172

    Pigmentation Disorders: Diagnosis and Management.
    Am Fam Physician 2017 Dec;96(12):797-804
    Norton Audobon Hospital, Louisville, KY, USA.
    Pigmentation disorders are commonly diagnosed, evaluated, and treated in primary care practices. Typical hyperpigmentation disorders include postinflammatory hyperpigmentation, melasma, solar lentigines, ephelides (freckles), and café au lait macules. These conditions are generally benign but can be distressing to patients. Read More

    Clinical profile of 300 men with facial hypermelanosis.
    J Dermatol Case Rep 2017 Dec 1;11(2):20-24. Epub 2017 Dec 1.
    Department of Dermatology, Venereology & Leprosy, Dr. R. P. Govt. Medical College, Kangra (Tanda)-176001 (Himachal Pradesh), India.
    Background: Facial hypermelanosis is a significant cause of cosmetic disfigurement, social embarrassment and psychological morbidity affecting quality of life.

    Objective: To study clinicoepidemlogic patterns of facial hypermelanoses among men.

    Material And Methods: Medical records of all adult males presenting with facial hypermelanoses were analyzed for this retrospective cross sectional study for demographic details, duration, cosmetic usage, sun exposure, drug intake, infections, systemic or cutaneous diseases, and family history of hypermelanotic dermatosis. Read More

    [Phakomatosis pigmentovascularis cesioflammea: a case report].
    Arch Argent Pediatr 2018 Feb;116(1):e121-e124
    Servicio de Dermatología, Hospital Nacional de Pediatría "Prof. Dr. J. P. Garrahan", Ciudad Autónoma de Buenos Aires.
    Phakomatosis pigmentovascularis (PPV) is a syndrome characterized by the association of a vascular nevus with a congenital pigmented lesion (epidermal nevus, nevus spilus, and dermal melanocytosis). There are different types of PPV according to the pigmentary nevus associated with the vascular malformation. Patients may present only the cutaneous condition or have systemic manifestations, among them, trauma, neurological and ophthalmological disorders. Read More

    Mosaic NRASopathy n a child with giant melanocytic congenital naevus, epidermal hamartoma and bilateral nephroblastomatosis: clinical implication for follow-up.
    J Eur Acad Dermatol Venereol 2018 Jan 5. Epub 2018 Jan 5.
    Department of Dermatology and Pediatric Dermatology, National Reference Centre for Rare Disorders, Hôpital des enfants Pellegrin, Centre Hospitalier Universitaire du Bordeaux, Bordeaux, France.
    Various nevoid proliferations result from postzygotic mutation in genes within the RAF/RAS/MAPK pathway, supporting the term "mosaic RASopathy"(1). Giant congenital melanocytic naevus (GCMN) and neurocutaneous melanosis are rare mosaic RASopathies mainly known to be at risk for the development of melanoma and skeletal anomalies are variably recorded (2,3). This article is protected by copyright. Read More

    [A woman with hyperpigmentation and dark urine].
    Ned Tijdschr Geneeskd 2017 ;161(0):D1944
    Antoni van Leeuwenhoek Ziekenhuis, afd. Medische Oncologie, Amsterdam.
    A 54-year-old patient was evaluated because of fever shortly after she had started treatment of a BRAF-mutated melanoma with BRAF- and MEK-inhibitors. Diffuse hyperpigmentation of the skin was noted as an incidental finding. She also had darkly coloured urine. Read More

    Pigmented epithelioid melanocytoma with nodal melanosis: A rare cause of cystic cervical lymphadenopathy.
    Head Neck 2018 Jan 2. Epub 2018 Jan 2.
    Department of General Surgery, Sengkang General Hospital, Singapore.
    Background: Head and neck malignancies often present as firm, solid nodal masses. However, malignancies arising from Waldeyer's Ring may give rise to cystic lymph nodes.

    Methods: A 57-year-old man was referred for left-sided neck swelling of 2 weeks' duration. Read More

    Skin autofluorescence reflects individual seasonal UV exposure, skin photodamage and skin cancer development in organ transplant recipients.
    J Photochem Photobiol B 2018 Jan 6;178:577-583. Epub 2017 Dec 6.
    Department of Dermato-venerology, Bispebjerg University Hospital, 2400 Copenhagen, Denmark.
    Importance: Ultraviolet radiation (UVR)-induced skin cancers varies among organ transplant recipients (OTRs). To improve individual risk assessment of skin cancer, objectively quantified skin photodamage is needed.

    Objectives: We measured personal UVR-exposure dose in OTRs and assessed the relation between individual UVR exposure, skin cancer and objectively measured photodamage in terms of skin autofluorescence, pigmentation, and black light-evaluated solar lentigines. Read More

    Diffuse cutaneous melanosis: rare complication of metastatic melanoma.
    An Bras Dermatol 2017 ;92(5 Suppl 1):62-64
    Private practice - Brasília (DF), Brazil.
    Diffuse cutaneous melanosis is a rare complication of metastatic melanoma related to a worse prognosis. There are few cases reported in the literature. Its pathogenesis has not been completely elucidated, although studies have suggested certain mechanisms for its occurrence. Read More

    A novel germline mutation (c.A527G) in STK11 gene causes Peutz-Jeghers syndrome in a Chinese girl: A case report.
    Medicine (Baltimore) 2017 Dec;96(49):e8591
    aDepartment of Medical Genetics, Naval Medical University, Shanghai 200433, ChinabHebei North University, Zhangjiakou, Hebei Province, ChinacDepartment of Gastroenterology, Airforce General Hospital of PLA, Beijing, China.
    Rationale: Peutz-Jeghers syndrome (PJS) is a Mendelian autosomal dominant disease caused by mutations in the tumor suppressor gene, serine/threonine kinase 11 (STK11). The features of this syndrome include gastrointestinal (GI) hamartomas, melanin spots on the lips and the extremities, and an increased risk of developing cancer. Early onset of disease is often characterized by mucocutaneous pigmentation and intussusception due to GI polyps in childhood. Read More

    A giant and extensive solitary Peutz-Jeghers-type polyp in the antrum of stomach: Case report.
    Medicine (Baltimore) 2017 Dec;96(49):e8466
    aDepartment of Gastroenterology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, ChinabDepartment of Gastroenterology, Xi'an Children's Hospital, Xi'an, Shaanxi, China.
    Rationale: A solitary Peutz-Jeghers-type polyp is a hamartomatous polyp which without either mucocutaneous pigmentation or a family history of Peutz-Jeghers syndrome (PJS). It can occur in all of the gastrointestinal tract, but it is extremely rare in the stomach.

    Patient Concerns: A 53-year-old man was admitted to the local hospital with left upper abdominal pain lasting 2 weeks. Read More

    Hyperpigmentation of the hard palate mucosa in a patient with chronic myeloid leukaemia taking imatinib.
    Maxillofac Plast Reconstr Surg 2017 Dec 5;39(1):37. Epub 2017 Dec 5.
    Maxillo-Facial and Dental Unit, Fondazione Ca' Granda IRCCS Ospedale Maggiore Policlinico, University of Milan, Via Commenda 10, 20122 Milan, Italy.
    Background: Imatinib mesylate is an inhibitor of the tyrosine kinase Bcr-Abl and a first-line treatment for Philadelphia chromosome-positive chronic myeloid leukaemia (CML). Dermatological side effects include superficial oedema, pustular eruption, lichenoid reactions, erythroderma, and skin rash. Depigmentation of the skin and/or mucosa is uncommon, and hyperpigmentation is rare. Read More

    Treatment of Melasma and Post-Inflammatory Hyperpigmentation by a Picosecond 755-nm Alexandrite Laser in Asian Patients.
    Ann Dermatol 2017 Dec 30;29(6):779-781. Epub 2017 Oct 30.
    Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
    The picosecond lasers have shown to effectively treat tattoo pigments that are intractable to previous multiple Q-switched (QS) laser treatments. Therefore we hypothesized that a picosecond laser would show better efficacy with minimal adverse events in the treatment of melasma and post-inflammatory hyperpigmentation (PIH) that are difficult to treat with conventional QS lasers. Two patients with melasma and one patient with PIH were treated with a Picosecond 755-nm Alexandrite Laser (Cyanosure, USA). Read More

    Genetic determinants of freckle occurrence in the Spanish population: Towards ephelides prediction from human DNA samples.
    Forensic Sci Int Genet 2018 Mar 23;33:38-47. Epub 2017 Nov 23.
    Department of Medicine, Jaume I University of Castellon, Ave. Sos Baynat, 12071, Castellon, Spain. Electronic address:
    Prediction of human pigmentation traits, one of the most differentiable externally visible characteristics among individuals, from biological samples represents a useful tool in the field of forensic DNA phenotyping. In spite of freckling being a relatively common pigmentation characteristic in Europeans, little is known about the genetic basis of this largely genetically determined phenotype in southern European populations. In this work, we explored the predictive capacity of eight freckle and sunlight sensitivity-related genes in 458 individuals (266 non-freckled controls and 192 freckled cases) from Spain. Read More

    Sanger sequencing in exonic regions of STK11 gene uncovers a novel de-novo germline mutation (c.962_963delCC) associated with Peutz-Jeghers syndrome and elevated cancer risk: case report of a Chinese patient.
    BMC Med Genet 2017 11 15;18(1):130. Epub 2017 Nov 15.
    Department of Medical Genetics, Naval Medical University, 800 Xiangyin Rd, Shanghai, 200433, China.
    Background: Peutz-Jeghers syndrome (PJS) is caused by mutations in the tumor suppressor gene, STK11, and is characterized by gastrointestinal hamartomas, melanin spots on the lips and the extremities, and an increased risk of developing cancer.

    Case Presentation: We reported an isolated PJS patient who died of colon cancer, whose blood sample was collected together with all the available family members'. The entire coding region of the STK11 gene was amplified by PCR and analyzed by Sanger sequencing, through which, a novel mutation, c. Read More

    Keratinocyte Sonic Hedgehog Upregulation Drives the Development of Giant Congenital Nevi via Paracrine Endothelin-1 Secretion.
    J Invest Dermatol 2017 Nov 11. Epub 2017 Nov 11.
    Drug Discovery Group, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia. Electronic address:
    Giant congenital nevi are associated with clinical complications such as neurocutaneous melanosis and melanoma. Virtually nothing is known about why some individuals develop these lesions. We previously identified the sonic hedgehog (Shh) pathway regulator Cdon as a candidate nevus modifier gene. Read More

    Melanosis coli: Harmless pigmentation? A case-control retrospective study of 657 cases.
    PLoS One 2017 31;12(10):e0186668. Epub 2017 Oct 31.
    Department of Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China.
    Backgrounds And Aims: The association of melanosis coli with the development of colorectal polyps remains uncertain.

    Methods: From a total of 18263 patients who had received colonoscopy in our hospital, 219 with melanosis coli cases and 438 controls matched by age and sex (at 1:2 ratio) were included in this study. The association of incidence, number, location, and pathology of colorectal neoplasm with grades and distribution of melanosis coli were analyzed. Read More

    Conjunctival changes in different clinical variants of early pseudoexfoliation.
    Int Ophthalmol 2017 Oct 30. Epub 2017 Oct 30.
    Glaucoma Diagnostic Service, LV Prasad Eye Institute, Patia, Bhubaneswar, Odisha, 751024, India.
    Purpose: To evaluate the conjunctival signs in different forms of pseudoexfoliation (PXF) syndrome to identify signs predicting early forms of the disease.

    Methods: This observational study included patients with newly diagnosed PXF screened in the outpatient department of glaucoma services. Slit lamp photographs were captured in low and high magnification after full dilatation, and details like melanotic pigmentation, vascularity and tortuosity of vessels, scarring if any, presence of pterygium and actinic changes along with basal Schirmer's test were analysed. Read More

    Benefits of Urologic-Dermatologic Consultations for the Diagnosis of Cutaneous Penile Lesions: A Prospective Study.
    Clin Genitourin Cancer 2017 Oct 5. Epub 2017 Oct 5.
    Department of Urology, Angers University Hospital, Angers, France.
    Introduction: We evaluated the benefits of a specialized consultation created in 2014 for cutaneous penile lesions.

    Materials And Methods: We performed a descriptive prospective study evaluating all patients sent for a monthly urologic-dermatologic consultation at a French university hospital from September 2014 to September 2015 for cutaneous penile lesions. All patients evaluated were included. Read More

    Morphologic and Elemental Analysis of Primary Melanosis of the Dentate Nucleus: Review and Correlation With Neuromelanin.
    J Neuropathol Exp Neurol 2017 Nov;76(11):949-956
    Department of Pathology, School of Medicine, University of South Florida-Morsani, Tampa, Florida; Medical College of Georgia, Augusta University, Augusta, Georgia.
    Primary melanosis of the dentate nucleus is a rarely described entity with neither known cause nor definitive clinicopathologic correlation. We revisit this previously reported phenomenon by presenting one such case with a review of the pathology as well as additional investigations including elemental analysis by energy-dispersive X-ray, immunohistochemistry and electron microscopy. The lesion presented macroscopically as a sharply defined, black pigmentation that was restricted to the dentate nucleus of the cerebellum. Read More

    Dermoscopy and patch testing in patients with lichen planus pigmentosus on face: A cross-sectional observational study in fifty Indian patients.
    Indian J Dermatol Venereol Leprol 2017 Nov-Dec;83(6):656-662
    Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.
    Background: Lichen planus pigmentosus (LPP) is a common cause of facial melanosis in the dark-skinned population. At present, information on dermoscopy and patch testing in LPP is limited.

    Objectives: To describe dermoscopic findings and study the role of patch testing in patients with LPP on the face. Read More

    A 23-Nucleotide Deletion in STK11 Gene Causes Peutz-Jeghers Syndrome and Malignancy in a Chinese Patient Without a Positive Family History.
    Dig Dis Sci 2017 11 6;62(11):3014-3020. Epub 2017 Oct 6.
    Department of Medical Genetics, Naval Medical University, 800 Xiangyin Rd., Shanghai, 200433, China.
    Background And Aims: Peutz-Jeghers syndrome (PJS) is an autosomal-dominant genetic disease caused by mutations in the tumor suppressor gene, STK11, which is characterized by gastrointestinal hamartomas, melanin spots on the lips and the extremities, and an increased risk of developing both gastrointestinal and extraintestinal malignancies.

    Methods And Results: We treated a PJS patient without a positive family history, who possessed typical clinical manifestations including polyp canceration. In order to explore the genotype of this patient, blood samples were collected from all the available family members. Read More

    Treatment of Freckles Using a Fractional Nonablative 2940nm Erb:YAG Laser in a Series of Asian Patients.
    J Clin Aesthet Dermatol 2017 Aug 1;10(8):28-30. Epub 2017 Aug 1.
    Dr. Tian is with Singapore General Hospital, Singapore.
    The purpose of this study was to demonstrate a novel, effective, and safe way to utilize the Erb:YAG laser to clear freckles in Type III/IV Asian skin.This was a prospective study.The setting was a Singapore-based clinic. Read More

    Urothelial melanosis of the bladder.
    Can J Urol 2017 Oct;24(5):9035-9037
    Division of Urology, University of Connecticut Health Center, Farmington, Connecticut, USA.
    Urothelial melanosis is a rare finding characterized by abnormal pigmentation noted on cystoscopic evaluation and histologically defined by melanin deposition in the urothelium. Although generally considered benign, few cases of urothelial melanosis have been reported in the literature and the risk of recurrence or progression remains largely unknown. Four cases associated with urothelial cell carcinoma have been previously described. Read More

    Dermatoscopic evaluation and histopathological correlation of acquired dermal macular hyperpigmentation.
    Int J Dermatol 2017 Dec 3;56(12):1395-1399. Epub 2017 Oct 3.
    Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
    Background: Acquired dermal macular hyperpigmentation (ADMH) is a hypernym encompassing Riehl's melanosis, lichen planus pigmentosus, and ashy dermatoses that show significant clinicopathological overlap. We sought to describe the dermatoscopic features of ADMH and correlate them with histopathological findings.

    Methods: This was a prospective observational study performed in two phases. Read More

    Surgical amniotic membrane transplantation after conjunctival and limbal tumor excision.
    Arq Bras Oftalmol 2017 Jul-Aug;80(4):242-246
    Department of Ophthalmology, Ankara Training and Research Hospital, Ankara, Turkey.
    Purpose:: To evaluate the clinical results of patients treated by amniotic membrane transplantation (AMT) following excision of conjunctival and limbal tumors.

    Methods:: A total of 14 eyes of 14 patients who underwent AMT after total lesion-free tumor excision and perilesional cryotherapy were evaluated.

    Results:: The excised tumors comprised 7 conjunctival intraepithelial neoplasia, 5 conjunctival nevus, 1 primary acquired melanosis, and 1 squamous cell carcinoma. Read More

    Penile Melanosis Associated with Lichen Sclerosus et Atrophicus: First Description in the Medical Literature.
    Open Access Maced J Med Sci 2017 Aug 10;5(5):692-693. Epub 2017 Aug 10.
    Medical Institute of Ministry of Interior (MVR), Department of Dermatology and Dermatologic Surgery, Generel Skobelev 79, 1606 Sofia, Bulgaria.
    We present a 74-year-old male patient with 3-years history of visible discoloration of the glans penis, without subjective complaints. Histopathological examination after incision biopsy revealed a moderate increase in the number of melanocytes in the basal layer with irregular distribution, without melanocytic nests, melanophages in the superficial dermis, and subepidermal sclerosus. No cytologic atypia of melanocytes was detectable. Read More

    Combination of Q-Switched Nd:YAG and Fractional Erbium:YAG Lasers in Treatment of Melasma: A Randomized Controlled Clinical Trial.
    J Lasers Med Sci 2017 8;8(1):1-6. Epub 2017 Jan 8.
    Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.
    Ablative and nonablative lasers have been used to treat melasma. We aimed to assess and compare the combining Q-switched Nd:YAG laser (QSNYL) and fractional erbium:YAG laser (FEYL) with QSNYL alone in treatment of melasma.This randomized controlled clinical trial was performed in our Research Center during 2013-2014. Read More

    Outcome Analyses of 15,189 Screenings Via Colonoscopy.
    Surg Laparosc Endosc Percutan Tech 2017 Oct;27(5):400-403
    Departments of *Gastroenterology †Trauma and Orthopaedics, The Second Hospital of Shandong University, Shandong Province, Peoples Republic of China.
    Purpose: This study investigated the detection rates of common colorectal diseases during colonoscopy procedures to provide reference for clinical diagnoses in China.

    Methods: A total of 15,189 participants, who underwent total colonoscopy, were studied. We analyzed the detection rates of common colorectal diseases in different sex, age, and decade groups. Read More

    [Current Therapies in Superficial Malignant Tumors].
    Klin Monbl Augenheilkd 2017 Sep 12. Epub 2017 Sep 12.
    Zentrum für Augenheilkunde, Universitätsklinikum Essen, Essen.
    This article is a review of diagnostic and therapeutic possibilities in common epibulbar malignant tumors, such as basal cell carcinoma, conjunctival lymphoma, squamous cell carcinoma and conjunctival melanoma. Most importantly, for every tumor patient there is a detailed anamnesis, split lamp examination and photo documentation. Further regular controls after therapy are required due to the risk of recurrences. Read More

    Systemic BRAF/MEK Inhibitors as a Potential Treatment Option in Metastatic Conjunctival Melanoma.
    Ocul Oncol Pathol 2017 Jul 8;3(2):133-141. Epub 2016 Dec 8.
    Department of Ophthalmology, University of Cologne, Cologne, Germany.
    Aim: In this review, we outline similarities between conjunctival and skin melanoma as well as the effectiveness of combined BRAF/MEK inhibition in melanoma, and discuss the applicability of these agents in conjunctival melanoma.

    Methods: The study provides a PubMed literature review.

    Results: Conjunctival melanoma and skin melanoma are genetically and phenotypically related. Read More

    Oral melanoma and other pigmentations: when to biopsy?
    J Eur Acad Dermatol Venereol 2018 Feb 14;32(2):209-214. Epub 2017 Sep 14.
    Dermatology, Department of Experimental Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
    Oral pigmentations (OPs) are often neglected, although a meticulous examination of the oral cavity is important not only in the diagnosis of oral melanoma, but also for the detection of important clinical findings that may indicate the presence of a systemic disease. OPs may be classified into two major groups on the basis of their clinical appearance: focal and diffuse pigmentations, even though this distinction may not appear so limpid in some cases. The former include amalgam tattoo, melanocytic nevi, melanoacanthoma and melanosis, while the latter include physiological/racial pigmentations, smoker's melanosis, drug-induced hyperpigmentations, postinflammatory hyperpigmentations and OPs associated with systemic diseases. Read More

    Peppered and rare - Gastric and Duodenal Pseudomelanosis: A case series.
    Pak J Med Sci 2017 May-Jun;33(3):757-760
    Michael Demyen, Department of Gastroenterology and Hepatology, Rutgers University, Newark, NJ, USA.
    Upper Gastrointestinal (GI) pseudomelanosis is an uncommon entity characterized by endoscopic visualization of speckled dark mucosal pigmentation. While described in the rectum and colon, 'melanosis' or more aptly 'pseudomelanosis' is rare in the duodenum and exceedingly rare in the stomach. Five cases of pseudomelanosis were encountered at our department. Read More

    A Retrospective Study, an Initial Lesion of Primary Malignant Melanoma of the Esophagus Revealed by Endoscopy.
    Intern Med 2017 Aug 1;56(16):2133-2137. Epub 2017 Aug 1.
    Department of Gastroenterology, Akita University Graduate School of Medicine, Japan.
    A 66-year-old man presented to his previous physician with epigastric discomfort in 2014. He was then referred to our hospital due to suspected primary malignant melanoma of the esophagus (PMME). A biopsy showed atypical cells containing melanin granules. Read More

    Occupational Argyria of the Nasal Mucosa.
    Head Neck Pathol 2017 Aug 4. Epub 2017 Aug 4.
    Otorhyniloaryngology Unit, Civitanova Marche General Hospital, Civitanova Marche, Italy.
    A biopsy specimen from the nasal mucosa of a 37-year-old man disclosed a subepithelial accumulation of black granules mainly running parallel to the surface in the absence of any inflammatory infiltrate. Since the mucosal pigment was negative with Perls' stain and resisted to melanin bleach, an exogenous pigmentation was suspected. The biopsy specimen had been taken because of a diffuse steel-blue pigmentation of the nasal mucosa, incidentally discovered during routine clinical examination. Read More

    Vulvar Neoplasms, Benign and Malignant.
    Obstet Gynecol Clin North Am 2017 Sep;44(3):339-352
    Bethesda Dermpath Laboratory, 1730 Elton Road, Suite 11, Silver Spring, MD 20903, USA; Anne Arundel Dermatology, Towson, MD 21204, USA; Pathology, Johns Hopkins University, 4940 Bayview Medical Center, Eastern Avenue, Baltimore, MD 21224, USA. Electronic address:
    Cutaneous vulvar neoplasms are commonly encountered at gynecology visits, with 2% of women having a benign vulvar melanocytic nevus and 10% to 12% of nevi being vulvar. High-grade squamous intraepithelial lesions (vulvar intraepithelial neoplasia 2 or 3) occurs in 5 per 100,000 women, with increasing incidence in the past 30 years. The recognition of these lesions and differentiation between benign, premalignant, and malignant stages are crucial for adequate diagnosis, clinical monitoring, and treatment. Read More

    Effect of chitosan-carvacrol coating on the quality of Pacific white shrimp during iced storage as affected by caprylic acid.
    Int J Biol Macromol 2018 Jan 1;106:123-129. Epub 2017 Aug 1.
    College of Food and Medicine, Zhejiang Ocean University, Zhoushan 316022, China; Key Laboratory of Health Risk Factors for Seafood of Zhejiang Province, Zhejiang Ocean University, Zhoushan 316022, China. Electronic address:
    This study aimed to investigate the effect of chitosan-carvacrol coating with or without caprylic acid (CAP) on the quality of Pacific white shrimp (Litopenaeus vannamei) during 10days of iced storage. The result showed that chitosan-carvacrol coating significantly inhibited the increase in total aerobic plate count (TPC), pH and total volatile basic nitrogen content (TVB-N) of shrimp in comparison with the control. Chitosan-carvacrol coating also delayed the melanosis formation and changes of ΔE values, and improved the texture and sensory properties of shrimp. Read More

    Gingival Pigmentation Affected by Smoking among Different Age Groups: A Quantitative Analysis of Gingival Pigmentation Using Clinical Oral Photographs.
    Int J Environ Res Public Health 2017 Aug 4;14(8). Epub 2017 Aug 4.
    Section of Geriatric Dentistry, Department of General Dentistry, Fukuoka Dental College, Fukuoka 814-0193, Japan.
    The presence of any age-related differences in gingival pigmentation associated with smoking, particularly in a young population, remains to be fully investigated. The purpose of this study was to determine the age-related differences in smoking gingival pigmentation. Gingival pigmentation was analyzed using the gingival melanosis record (GMR) and Hedin's classification with frontal oral photographs taken at 16 dental offices in Japan. Read More

    Influence of Repeated Senna Laxative Use on Skin Barrier Function in Mice.
    Ann Dermatol 2017 Aug 21;29(4):414-421. Epub 2017 Jun 21.
    Department of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, Mie, Japan.
    Background: Senna, one of the major stimulant laxatives, is widely used for treating constipation. Chronic senna use has been reported to be associated with colonic disorders such as melanosis coli and/or epithelial hyperplasia. However, there is no obvious information on the influence of chronic senna use on organs except for the intestine. Read More

    Bioconcentration and Metabolism of Emodin in Zebrafish Eleutheroembryos.
    Front Pharmacol 2017 11;8:453. Epub 2017 Jul 11.
    School of Pharmaceutical Sciences, Sun Yat-sen UniversityGuangzhou, China.
    Emodin is a major active anthraquinone of various herbal laxatives, which can exert many pharmacological effects. However, chronic use of anthranoid laxatives, even at low dosages, may cause melanosis coli (MC). It has been suggested that the accumulation of anthraquinones is a risk factor in the MC process. Read More

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