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    Loss of Pigment in Becker's Melanosis.
    Indian J Dermatol Venereol Leprol 1979 Mar-Apr;45(2):116-118
    Two male patients with Becker's melanosis are described. The observation of depigmentation and leucotrichia in the lesion in one of them is regarded extremely unusual. The histopathological features comprised of marked acanthosis, papillomatosis, increased basal pigmentation and hyalinization of dermal connective tissue. Read More

    Soft palatal melanosis, a simple predictor for neoplasia in the upper aerodigestive tract in Japanese alcoholic men.
    Cancer Sci 2017 Feb 20. Epub 2017 Feb 20.
    Department of Health Promotion, National Institute of Public Health, 2-3-6 Minami, Wako, Saitama, 351-0104, Japan.
    Soft palatal melanosis can be detected by visual inspection during routine physical examination or even personally in a mirror. The aim of this study was to evaluate the association between squamous cell neoplasia in the upper aerodigestive tract (UAT) and the soft palatal melanosis. We reviewed digitalized records of high-quality endoscopic images of the soft palate of 1786 Japanese alcoholic men who underwent endoscopic screening. Read More

    African ancestry is associated with facial melasma in women: a cross-sectional study.
    BMC Med Genet 2017 Feb 17;18(1):17. Epub 2017 Feb 17.
    Department of Dermatology, FMB-Unesp, Botucatu, SP, Brazil.
    Background: Melasma is a chronic acquired focal hypermelanosis affecting photoexposed areas, especially for women during fertile age. Several factors contribute to its development: sun exposure, sex steroids, medicines, and family history. Melanic pigmentation pathway discloses several SNPs in different populations. Read More

    [Primary malignant melanoma in the brain of a 7-month-old sheep (Ovis aries f. domestica)].
    Tierarztl Prax Ausg G Grosstiere Nutztiere 2017 Feb 15. Epub 2017 Feb 15.
    Dr. Dr. habil. Wolfram Breuer, Bayerisches Landesamt für Gesundheit und Lebensmittelsicherheit, Oberschleißheim, Veterinärstraße 2, 85764 Oberschleißheim, E-Mail:
    A case of malignant melanoma in a sheep's brain is described for the first time. In a 7-month-old sheep that had been euthanized due to ataxia, post-mortem and histopathologic examinations were performed. Both the brain and the calvarium were heavily infiltrated with neoplastic tissue. Read More

    Common Skin Conditions in Children: Neonatal Skin Lesions.
    FP Essent 2017 Feb;453:11-17
    University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.
    Skin findings during the initial month of life are ubiquitous. One study estimated that more than 95% of newborns have cutaneous findings, which often are distressing to parents but frequently are benign and self-limited. Among them are milia, cutis marmorata, congenital dermal melanocytosis, and the benign neonatal pustular eruptions (eg, benign cephalic pustulosis, erythema toxicum neonatorum, transient neonatal pustular melanosis). Read More

    Immunohistochemical profiling including beta-catenin in conjunctival melanocytic lesions.
    Exp Mol Pathol 2017 Feb 1;102(2):198-202. Epub 2017 Feb 1.
    Department of Pathology, Division of Neuropathology, University of Washington School of Medicine and Harborview Medical Center, Seattle, WA, United States. Electronic address:
    Conjunctival melanocytic lesions encompass a group of clinically diverse, benign to malignant, neoplasms that may contain overlapping histopathological features, making definitive diagnosis challenging in some cases. In this series, we compared multiple immunohistochemical (IHC) markers in 11 conjunctival nevi, 10 primary acquired melanosis (PAM) lesions, and 11 conjunctival melanomas. Immunostains included the melanocytic markers HMB-45 and Melan-A, as well as the proliferative marker Ki-67. Read More

    [Melanocytoma and meningeal melanocytosis, similar but different lesions].
    Cir Cir 2017 Jan 23. Epub 2017 Jan 23.
    Servicio de Patología, Hospital Juárez de México, Ciudad de México, México.
    Background: Meningeal melanomatosis is an extra-axial well-encapsulated malignant tumour with diffuse meningeal growth and dark coloration (due to high melanin contents), while meningeal melanocytoma is the focalized benign variant. Melanocytic lesions may be secondary to melanoma or be histologically benign, however, their diffuse nature makes them impossible to cure. Melanocytosis is a diffuse tumour that can form solitary extra-axial tumours, which invades the parenchyma and presents signs of malignancy with increased mitosis and Ki67, observed in 1 to 6% of immunopathological exams. Read More

    Clinical Features Differentiating Benign From Malignant Conjunctival Tumors in Children.
    JAMA Ophthalmol 2017 Jan 26. Epub 2017 Jan 26.
    Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.
    Importance: Conjunctival tumors in children are usually benign and rarely malignant.

    Objective: To evaluate clinical features of conjunctival tumors in children by comparing benign tumors with their malignant counterparts.

    Design, Setting, And Participants: This retrospective case series reviewed 806 cases of conjunctival tumor in children (aged <21 years) who were evaluated at a tertiary referral center between November 1, 1975, and July 1, 2015. Read More

    Primary cerebral malignant melanoma: A case report with literature review.
    Medicine (Baltimore) 2017 Jan;96(4):e5805
    aDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University bDepartment of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Dongcheng District, Beijing, P. R. China cDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Harvard University, Boston, MA dDepartment of Neurovascular Surgery, Chinese Armed Police General Hospital, Haidian District eDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Xuanwu District, Beijing, P. R. China.
    Primary intracranial melanomas are uncommon and constitute approximately 1% of all melanoma cases and 0.07% of all brain tumors. In nature, these primary melanomas are very aggressive and can spread to other organs. Read More

    Congenital Melanocytic Nevus Syndrome: A Case Series.
    Actas Dermosifiliogr 2017 Jan 19. Epub 2017 Jan 19.
    Servicio de Anatomía Patológica, Complejo Hospitalario de Toledo, Toledo, España.
    Congenital melanocytic nevus syndrome (CMNS) is the result of an abnormal proliferation of melanocytes in the skin and central nervous system caused by progenitor-cell mutations during embryonic development. Mutations in the NRAS gene have been detected in many of these cells. We present 5 cases of giant congenital melanocytic nevus, 3 of them associated with CMNS; NRAS gene mutation was studied in these 3 patients. Read More

    Nasal mucosal melanosis may act as a harbinger of melanoma: A case report.
    Allergy Rhinol (Providence) 2016 Jan;7(3):164-167
    Background: The progression from a benign pigmented lesion on the skin to cutaneous melanoma is better understood, and it could be presumed that a similar progression occurs with mucosal lesions. However, to our knowledge, there has never been documentation of melanosis transforming into melanoma over time.

    Objective: To describe a transformation of a mucosal melanosis into melanoma. Read More

    Clinical management of Candida albicans keratomycosis in a bottlenose dolphin (Tursiops truncatus).
    Vet Ophthalmol 2017 Jan 11. Epub 2017 Jan 11.
    U.S. Navy Marine Mammal Program, Space and Naval Warfare Systems Center Pacific, San Diego, CA, 92152, USA.
    Objective: Corneal ulceration secondary to trauma commonly affects marine mammals, often with opportunistic secondary bacterial or fungal infections. This report characterizes the combined use of auriculopalpebral and ophthalmic nerve blocks, adipose-derived stem cells, and subconjunctival injections for successful treatment of corneal trauma and infection in dolphins.

    Animal Studied: An 11-year-old, female bottlenose dolphin (Tursiops truncatus) presented with bilateral diffuse corneal opacities, which progressed to keratomycosis caused by Candida albicans. Read More

    Golden Needle Mushroom: A Culinary Medicine with Evidenced-Based Biological Activities and Health Promoting Properties.
    Front Pharmacol 2016 7;7:474. Epub 2016 Dec 7.
    Division of Genetics and Molecular Biology, Faculty of Science, Institute of Biological Sciences, University of Malaya Kuala Lumpur, Malaysia.
    Flammulina velutipes (enoki, velvet shank, golden needle mushroom or winter mushroom), one of the main edible mushrooms on the market, has long been recognized for its nutritional value and delicious taste. In recent decades, research has expanded beyond detailing its nutritional composition and delved into the biological activities and potential health benefits of its constituents. Many bioactive constituents from a range of families have been isolated from different parts of the mushroom, including carbohydrates, protein, lipids, glycoproteins, phenols, and sesquiterpenes. Read More

    A clinical, histologic, and follow-up study of genital melanosis in men and women.
    J Am Acad Dermatol 2016 Dec 13. Epub 2016 Dec 13.
    Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois; Robert H. Lurie Cancer Center, Northwestern University, Chicago, Illinois. Electronic address:
    Background: Genital melanosis may clinically mimic melanoma. Little is known about the potential risk for genital and nongenital melanoma in these patients.

    Objective: In this retrospective cohort study, we analyzed clinical and histologic data from patients with genital melanosis to better characterize these lesions and the risk they confer for genital and nongenital melanoma. Read More

    Mosaic NRAS Q61R mutation in a child with giant congenital melanocytic naevus, epidermal naevus syndrome and hypophosphataemic rickets.
    Clin Exp Dermatol 2017 Jan 30;42(1):75-79. Epub 2016 Nov 30.
    Department of Paediatric Dermatology, Birmingham Children's Hospital NHS Foundation Trust, Birmingham, UK.
    The association of hypophosphataemic rickets with verrucous epidermal naevus (EN) and elevated fibroblast growth factor 23 levels is known as cutaneous-skeletal hypophosphataemia syndrome (CSHS), and can be caused by somatic activating mutations in RAS genes. We report a unique patient with CSHS associated with giant congenital melanocytic naevus (CMN), neurocutaneous melanosis and EN syndrome, manifesting as facial linear sebaceous naevus, developmental delay and ocular dermoids. An activating mutation Q61R in the NRAS gene was found in affected skin and ocular tissue but not blood, implying that the disparate manifestations are due to a multilineage activating mutation (mosaic RASopathy). Read More

    Early diagnosis of genital mucosal melanoma: how good are our dermoscopic criteria?
    Dermatol Pract Concept 2016 Oct 31;6(4):43-46. Epub 2016 Oct 31.
    Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
    Background: There are limited studies on the dermoscopic features of mucosal melanoma, particularly early-stage lesions. Described criteria include the presence of blue, gray, or white colors, with a reported sensitivity of 100%. It is unclear if these features will aid in the detection of early mucosal melanoma or improve diagnostic accuracy compared to naked-eye examination alone. Read More

    Giant melanocytic nevi with neurocutaneous melanosis masquerading as neurofibromas.
    J Pediatr Neurosci 2016 Jul-Sep;11(3):258-260
    Department of Neuroradiology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
    Neurocutaneous melanosis is congenital melanocytic nevus with neurological manifestations. We report a 4-year-old female child presenting with hyperpigmented and nodular skin lesion associated with developmental delay and convulsions. The child had multiple brownish-black nevi on the face and chest and giant melanocytic nevi on thoraco-abdomen, back, and gluteal region. Read More

    Theoretical review of the treatment of pigmented lesions in Asian skin.
    Laser Ther 2016 Oct;25(3):179-184
    Department of Plastic Surgery, Tokai University.
    Asian skin has a higher epidermal melanin content, making it more likely to develop adverse pigmentary reactions following laser surgery. The nanosecond lasers are the gold standard for the treatment of pigmented lesions, but the risk of complications, such as post-inflammatory hyperpigmentation, is increased in dark-skinned patients. Intense Pulsed Light (IPL) or long-pulsed lasers are available for treating superficial pigmented lesions, and fewer complications are seen when using these devices compared to the nanosecond lasers. Read More

    Melanoma-Associated Spongiform Scleropathy in Oculodermal Melanocytosis with Primary Orbital Melanoma.
    Ocul Oncol Pathol 2016 Oct 16;2(4):276-279. Epub 2016 Jul 16.
    Department of Ophthalmology, Morsani College of Medicine, University of South Florida, Tampa, Fla., USA; Department of Pathology and Cell Biology, Morsani College of Medicine, University of South Florida, Tampa, Fla., USA.
    Purpose: To describe spongiform scleropathy in a patient with oculodermal melanosis and without evidence of uveal melanoma.

    Methods: Clinical-pathological correlation conducted in compliance with HIPPA (Health Insurance Privacy and Portability Act) regulations.

    Results: Melanoma-associated spongiform scleropathy was an incidental finding in an 87-year-old woman with oculodermal melanocytosis treated for primary orbital melanoma. Read More

    Adenoma Detection is Increased in the Setting of Melanosis Coli.
    J Clin Gastroenterol 2016 Nov 4. Epub 2016 Nov 4.
    *Department of Medicine, Division of Digestive and Liver Diseases, Columbia University College of Physicians and Surgeons †Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY.
    Goals: To compare the adenoma detection rate (ADR) during colonoscopy in patients with melanosis coli against matched controls without melanosis.

    Background: Melanosis coli is a colonoscopic finding in which the colon wall appears darkly pigmented, most often due to extended laxative use, and is considered benign. The pigmentation spares adenomas, which should therefore be more readily detectable in melanosis coli. Read More

    Neurocutaneous Melanosis Presenting as Cavernous Hemangioma Persistent Abdominal Pain.
    J Craniofac Surg 2016 Oct 27. Epub 2016 Oct 27.
    *Department of Neurosurgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai †Department of Neurosurgery, Longyan First Hospital Affiliated to Fujian Medical University, Longyan, China.
    Neurocutaneous melanosis (NCM) is a rare congenital syndrome characterized by the presence of multiple congenital melanocytic nevi and the proliferation of melanocytes in the central nervous system. The authors present a 9-year-old Chinese boy whose clinical manifestations are intermittent headache for 2 months and persistent abdominal pain for 10 days. 3D-reconstruction computed tomography angiography image, digital subtraction angiography, and magnetic resonance imaging plus angiography (MRI+MRA) examinations results suggested that cavernoma at left frontal lobe potentially associated with hemorrhage. Read More

    A Rare Disease of the Digestive Tract: Esophageal Melanosis.
    Gastroenterology Res 2016 Jun 18;9(2-3):56-60. Epub 2016 Jun 18.
    General Surgery Department, Medical Faculty, Istanbul University, Capa, Istanbul, Turkey.
    Esophageal melanosis which is characterized by melanocytic proliferation in the squamous epithelium of the esophagus and melanin accumulatin of esophageal mucosa (EM) is a rare disease of the digestive system. Although esophageal melanosis is considered to be a benign disease, its etiology is not cleared and has been reported to be the precursor lesion of esophageal primary melanomas. In this report, we aimed to note esophageal melanosis in a 55-year-old female case who applied to our clinic with difficulty in swallowing, burning behind the breastbone in the stomach, heartburn, indigestion, and pain in the upper abdomen after endoscopic and pathologic evaluation. Read More

    [The clinical and histopathological analysis of 2 053 cases of conjunctival neoplasms].
    Zhonghua Yan Ke Za Zhi 2016 Oct;52(10):738-744
    Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing TongRen Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Lab., Beijing 100005, China.
    Objective: We aimed to identify and describe the clinical and histopathologic characteristics of conjunctival neoplasms. Methods: Retrospective case series study. We collected and analyzed the clinical and histopathologic data of the conjunctival neoplastic specimens including the age, gender, and histopathologic diagnosis of all patients obtained from Beijing Tongren Eye Center between October 2003 and October 2015. Read More

    Eruptive Facial Postinflammatory Lentigo: Clinical and Dermatoscopic Features.
    Am J Dermatopathol 2016 Nov;38(11):813-819
    *Department of Dermatology, Clínica Alemana de Santiago, Chile; †Melanoma Unit, Department of Dermatology, Hospital Clinic of Barcelona, Barcelona, Spain; ‡Department of Pathology, Clínica Alemana de Santiago, Chile; §Department of Medicine, Hospital de Carabineros de Chile, Chile; and ¶Department of Dermatology, Universidad del Desarrollo, Chile.
    The face has not been considered a common site of fixed drug eruption, and the authors lack dermatoscopic studies of this condition on the subject. The authors sought to characterize clinical and dermatoscopic features of 8 cases of an eruptive facial postinflammatory lentigo. The authors conducted a retrospective review of 8 cases with similar clinical and dermatoscopic findings seen from 2 medical centers in 2 countries during 2010-2014. Read More

    [Woman 19-old with hirsutism, obesity and acanthosis nigricans].
    Pol Merkur Lekarski 2016 Sep;41(243):141-144
    Medical University of Warsaw, Poland: Student's Scientific Circle "Endocrinus", Department of Internal Medicine and Endocrinology.
    19-year-old hirsute woman with obesity, skin lesions with features of acanthosis nigricans around neck, armpits, thoracic cage and wrists escalating for couple of months, elevated testosterone and insulin plasma levels was admitted to hospital to perform diagnostic approach. The final diagnosis was hyperandrogenism-insulin resistance-acanthosis nigricans syndrome (HAIR-AN syndrome), considered as a subtype of policystic ovary syndrome (PCOS) and impaired glucose tolerance. HAIR-AN is characterized by coexistence of: hyperandrogenism (HA), insulin resistance (IR) and acanthosis nigricans (AN). Read More

    Comparative proteomic analysis of melanosis coli with colon cancer.
    Oncol Rep 2016 Dec 17;36(6):3700-3706. Epub 2016 Oct 17.
    Department of Gastroenterology, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan 471003, P.R. China.
    The present study aimed to investigate the proteomic difference between melanosis coli (MC) alone and melanosis coli with colon cancer (MCCC). Protein expression in patients with different diseases was analyzed using two-dimensional gel electrophoresis and matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF/TOF-MS). A total of 14 protein differences with a confidence level of >95% were found. Read More

    Conjunctival Tumors in 5002 Cases. Comparative Analysis of Benign Versus Malignant Counterparts. The 2016 James D. Allen Lecture.
    Am J Ophthalmol 2017 Jan 8;173:106-133. Epub 2016 Oct 8.
    Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.
    Purpose: To evaluate frequency of conjunctival tumors in all ages and compare benign vs malignant counterparts.

    Design: Retrospective series.

    Methods: setting: Tertiary referral center. Read More

    An Orbital Malignant Melanoma Arising in Cellular Blue Nevus in a Patient with Nevus of Ota.
    Cureus 2016 Jul 18;8(7):e698. Epub 2016 Jul 18.
    Medical Eye Associates, University of Central Florida College of Medicine.
    Melanomas arising from orbital melanocytic proliferations are exceedingly rare. Many questions remain regarding their development and malignant transformation. We report on a 45-year-old Caucasian woman with a nevus of Ota that presented with visual disturbances involving her right eye and was found to have a biopsy-proven cellular blue nevus in the orbital space. Read More

    Downregulation of melanogenesis: drug discovery and therapeutic options.
    Drug Discov Today 2017 Feb 28;22(2):282-298. Epub 2016 Sep 28.
    College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon 34134, South Korea.
    Melanin, primarily responsible in humans for hair, eye and skin pigmentation, is produced by melanocytes through a process called melanogenesis. However, the abnormal accumulation of melanin causes dermatological problems such as café-au-lait macules ephelides (freckles), solar lentigo (age spots) and melasma, as well as cancer and vitiligo. Hence the regulation of melanogenesis is very important for treating hyperpigmentary disorders. Read More

    Multifocal melanocytoma of the posterior fossa and subcutaneous scalp in the absence of neurocutaneous melanosis.
    Surg Neurol Int 2016 1;7(Suppl 23):S591-5. Epub 2016 Sep 1.
    Department of Neurosurgery, Saint Louis University, Saint Louis, Missouri, USA.
    Background: Primary leptomeningeal melanocytic neoplasms of the central nervous system are rare. Multifocal lesions typically occur in the setting of cutaneous melanosis. We present the first report of a posterior fossa melanocytoma and subcutaneous melanocytoma of intermediate grade in the absence of cutaneous melanosis. Read More

    Correlation of Lipid Profile and Risk of Developing Type 2 Diabetes Mellitus in 10-14 Year Old Children.
    Cell Physiol Biochem 2016 19;39(5):1695-1704. Epub 2016 Sep 19.
    Department of Pediatrics, University of North Texas Health Science Center, Fort Worth, TX, USA.
    Background/aims: The role of lipid profile in predicting the risk of Type 2 diabetes mellitus (T2DM) in children is not clearly established. Our aim is to screen non-diabetic children aged 10-14 years for risk of developing T2DM and evaluate the association of abnormal lipids and socioeconomic status (SES).

    Methods: Data on race/ethnicity, family history, body mass index percentile, blood pressure and presence of neck pigmentation (acanthosis nigricans) were collected from 149 non-diabetic children. Read More

    Prevalence of obesity and acanthosis nigricans among young children in the children's healthy living program in the United States Affiliated Pacific.
    Medicine (Baltimore) 2016 Sep;95(37):e4711
    aUniversity of Hawaii at Manoa, Honolulu bUniversity of Alaska, Fairbanks cNorthern Marianas College, Saipan dUniversity of Guam, Mangilao.
    Estimate prevalence of obesity and acanthosis nigricans (AN) among children in United States Affiliated Pacific (USAP) jurisdictions.Cross-sectional measurement of weight, height, and AN in 5775, 2 to 8 years old in 51 communities-Hawai'i, Alaska, Commonwealth of the Northern Mariana Islands, Guam, American Samoa, Palau, Republic of the Marshall Islands (RMI), 4 Federated States of Micronesia (Pohnpei, Yap, Kosrae, Chuuk). Analyses weighted to jurisdiction-specific sex and age distributions accounting for clustering of communities within jurisdictions. Read More

    Dermoscopy in General Dermatology: A Practical Overview.
    Dermatol Ther (Heidelb) 2016 Dec 9;6(4):471-507. Epub 2016 Sep 9.
    Department of Experimental and Clinical Medicine, Institute of Dermatology, University of Udine, Udine, Italy.
    Over the last few years, dermoscopy has been shown to be a useful tool in assisting the noninvasive diagnosis of various general dermatological disorders. In this article, we sought to provide an up-to-date practical overview on the use of dermoscopy in general dermatology by analysing the dermoscopic differential diagnosis of relatively common dermatological disorders grouped according to their clinical presentation, i.e. Read More

    Resolution of Acanthosis Nigricans Following Curative Gastric Carcinoma Resection.
    Clin Ter 2016 Jul-Aug;167(4):99-100
    Minimally Invasive, Upper Gastrointestinal and Bariatric Surgery Unit, Department of Surgery, Universiti Kebangsaan Malaysia Medical Centre (UKMMC), Kuala Lumpur, Malaysia.
    We discuss a 48-year old, who presented with upper epigastrium pain associated with early satiety and significant weight loss. Physical examination revealed a thickening and darkening of skins around the skin folds, scalp, back and front of abdomen. A diagnosis of gastro-esophageal junction adenocarcinoma was confirmed by oesophagogastroduodenoscopy (OGDS) and biopsy. Read More

    Syndromic Gastric Polyps: At the Crossroads of Genetic and Environmental Cancer Predisposition.
    Adv Exp Med Biol 2016;908:347-69
    Department of Pathology, The Johns Hopkins University School of Medicine, 401 N Broadway Weinberg 2242, Baltimore, MD, 21231, USA.
    Gastric polyps occur in 1-4 % of patients undergoing gastroscopy. Although most are sporadic, some gastric polyps are part of an underlying hereditary syndrome. Gastric polyps can be seen in each of the well-known gastrointestinal polyposis syndromes, but also in Lynch syndrome and in several rare not primarily gastrointestinal syndromes. Read More

    Subcutaneous melanocytoma mimicking a lipoma: a rare presentation of a rare neoplasm with histological, immunohistochemical, cytogenetic and molecular characterization.
    J Cutan Pathol 2016 Dec 27;43(12):1186-1196. Epub 2016 Sep 27.
    Department of Pathology, Saint Louis University School of Medicine, St. Louis, MO, USA.
    Melanocytoma are the melanocytic tumors originating from leptomeningeal melanocytes. Melanocytomas are commonly seen in the central nervous system (CNS) and are often associated with neurocutaneous melanosis (NCM). However, simultaneous presentation of intra-axial and extracranial melanocytoma is a very rare event. Read More

    Molecular changes in skin pigmented lesions of the coral trout Plectropomus leopardus.
    Mar Environ Res 2016 Sep 28;120:130-5. Epub 2016 Jul 28.
    School of Biological, Biomedical and Environmental Sciences, University of Hull, Cottingham Road, Hull, HU6 7RX, United Kingdom. Electronic address:
    A high prevalence of skin pigmented lesions of 15% was recently reported in coral trout Plectropomus leopardus, a commercially important marine fish, inhabiting the Great Barrier Reef. Herein, fish were sampled at two offshore sites, characterised by high and low lesion prevalence. A transcriptomic approach using the suppressive subtractive hybridisation (SSH) method was used to analyse the differentially expressed genes between lesion and normal skin samples. Read More

    Melanocytic Nevi in Children: A Review.
    Pediatr Ann 2016 Aug;45(8):e293-8
    Common moles on the skin, known scientifically as melanocytic nevi, are seen frequently in the pediatric population. They are broadly grouped into two groups: congenital (generally present at birth or in infancy) or acquired. Congenital melanocytic nevi (CMN) are classified based on size and morphologic features. Read More

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