9,191 results match your criteria Ephelides Freckles


Coating white shrimp (Litopenaeus vannamei) with edible fully deacetylated chitosan incorporated with clove essential oil and kojic acid improves preservation during cold storage.

Int J Biol Macromol 2020 Jun 28. Epub 2020 Jun 28.

School of Food Science and Technology, State Key Laboratory of Food Science and Technology, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, Jiangnan University, Lihu Road 1800, Wuxi 214122, Jiangsu, PR China.

The effect of fully deacetylated chitosan (FDCH) edible coating combined with kojic acid (KA) and clove essential oil (CEO) as natural preservatives was investigated on the shelf-life of white prawn shrimp (Litopenaeus vannamei) during 15 days at cold storage. The results indicated that FDCH:KA:CEO coating significantly inhibited the increase in total aerobic plate count, total volatile basic nitrogen content and pH of shrimp in comparison with the control. Moreover, compared with the control, the changes of total colour difference (ΔE values) and melanosis were significantly retarded, and the texture parameters and sensory scores were significantly improved in shrimp treated by FDCH:KA:CEO suggesting that there is a synergistic effect between FDCH, KA, and CEO. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2020.06.248DOI Listing

Q-Switched Nd:YAG (532 nm) Laser Versus Intra-Dermal Tranexamic Acid for Treatment of Facial Ephelides: A Split Face, Randomized, Comparative Trial.

Lasers Surg Med 2020 Jun 26. Epub 2020 Jun 26.

Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt.

Background And Objectives: To compare the efficacy and safety of intradermal injection of tranexamic acid (TXA) versus Q switched (QS) KTP (532 nm) in the treatment of facial ephelides.

Study Design/materials And Methods: A randomized comparative split-face study included a total of 30 female patients with bilateral facial ephelides. One cheek was treated by intra-dermal TXA injections and the other was treated by QS-KTP (532 nm). Read More

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http://dx.doi.org/10.1002/lsm.23291DOI Listing

Impact of Riehl's melanosis on quality of life in Korean patients: A cross-sectional comparative study.

J Dermatol 2020 Jun 26. Epub 2020 Jun 26.

Department of Dermatology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

The prevalence of Riehl's melanosis in Korea is increasing. However, little is known about the psychosocial burden of patients with Riehl's melanosis. This study was aimed to examine the level of psychosocial impact of Riehl's melanosis. Read More

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http://dx.doi.org/10.1111/1346-8138.15382DOI Listing

Identification of rhein as the metabolite responsible for toxicity of rhubarb anthraquinones.

Food Chem 2020 Jun 18;331:127363. Epub 2020 Jun 18.

Key Laboratory of Resource Biology and Modern Biotechnology in Western China, Ministry of Education, Northwest University, Xi'an 710069, China; Biomedicine Key Laboratory of Shaanxi Province, Northwest University, 710069 Xi'an, China. Electronic address:

Rhubarb is a popular food in Europe with laxative properties attributed to anthraquinones. Long term usage of rhubarb anthraquinones has been linked to colonic toxicity, including the formation of melanosis coli, which is associated with increased risk of colon cancer. The major purgative anthraquinone in rhubarb is thought to be sennoside A, which is metabolised by colonic microflora. Read More

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http://dx.doi.org/10.1016/j.foodchem.2020.127363DOI Listing

Treatment of henna-induced Riehl's melanosis with a 755-nm picosecond alexandrite laser.

Lasers Med Sci 2020 Jun 23. Epub 2020 Jun 23.

Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, Japan.

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http://dx.doi.org/10.1007/s10103-020-03077-0DOI Listing

The diagnostic conundrum of Riehl melanosis and other facial pigmentary disorders: a case report with overlapping clinical, dermoscopic, and histopathological features.

Acta Dermatovenerol Alp Pannonica Adriat 2020 Jun;29(2):81-83

Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Riehl melanosis (RM) is a form of pigmented contact dermatitis that often poses a diagnostic challenge due to overlaps in its clinical, dermoscopic, and histopathological features with other pigmentary disorders. This report highlights significant findings and the proper approach for diagnosis. We present the case of a 47-year-old female with progressive facial hyperpigmentation (irregular, blotchy, grayish patches on the forehead, cheeks, and around the mouth) that acknowledged applying a lightening product before her complaint. Read More

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Becker Melanosis.

Indian Pediatr 2020 Jun;57(6):597-598

Department of Dermatology, Venereology, and Leprosy, RG Kar Medical College, Kolkata, West Bengal, India.

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Melanosis of the bladder: A rare diagnosis.

Urol Case Rep 2020 Nov 27;33:101283. Epub 2020 May 27.

Urology Department, Brown University, Lifespan Health System, Providence, RI, USA.

Melanosis of the bladder is characterized by dark, velvety bladder mucosa due to melanin deposition. Less than 25 cases have been reported. We present a 45-year-old male undergoing work up for obstructive and storage irritative lower urinary tract symptoms, found to have diffuse bladder melanosis on cystoscopy with bladder biopsy, and detrusor overactivity on urodynamic study. Read More

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http://dx.doi.org/10.1016/j.eucr.2020.101283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286983PMC
November 2020

Guanine Deaminase in Human Epidermal Keratinocytes Contributes to Skin Pigmentation.

Molecules 2020 Jun 5;25(11). Epub 2020 Jun 5.

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea.

Epidermal keratinocytes are considered as the most important neighboring cells that modify melanogenesis. Our previous study used microarray to show that guanine deaminase (GDA) gene expression is highly increased in melasma lesions. Hence, we investigated the role of GDA in skin pigmentation. Read More

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http://dx.doi.org/10.3390/molecules25112637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321356PMC

Extensive Becker's Melanosis in a Checkerboard Mosaic Pattern.

Indian Dermatol Online J 2020 Mar-Apr;11(2):294-295. Epub 2020 Mar 9.

Department of Dermatology, Venereology and Leprology, R.N.T. Medical College, Udaipur, Rajasthan, India.

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http://dx.doi.org/10.4103/idoj.IDOJ_137_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247657PMC

A case of acanthosis nigricans in a HIV-infected patient.

BMC Infect Dis 2020 May 20;20(1):360. Epub 2020 May 20.

Department of Public Health and Infectious Diseases, "Sapienza" University of Rome, Rome, Italy.

Background: To date, very little information is available concerning the relationship between acanthosis nigricans (AN) and infection with human immunodeficiency virus type 1 (HIV-1).

Case Presentation: Herein, we report the case of a middle-aged man admitted for fever and progressively worsening dyspnea in the context of an opportunistic pneumonia and firstly diagnosed with acquired immunodeficiency syndrome (AIDS). At the time of diagnosis, physical examination revealed the presence of a palpable, hyperpigmented skin lesion on the left areola with surface desquamation and velvety texture consistent with AN. Read More

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http://dx.doi.org/10.1186/s12879-020-05089-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238735PMC

Maturational Hyperpigmentation: Cutaneous Marker of Metabolic Syndrome.

Dermatol Pract Concept 2020 20;10(2):e2020046. Epub 2020 Apr 20.

Cosmasure Skin Hair, Fat Management and Laser Clinic, Jabalpur, India.

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http://dx.doi.org/10.5826/dpc.1002a46DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190466PMC

Interferon Alfa-2b for Pigmented Ocular Surface Squamous Neoplasia: A Report of 8 Lesions.

Cornea 2020 Apr 29. Epub 2020 Apr 29.

Operation Eyesight Universal Institute for Eye Cancer, LV Prasad Eye Institute, Hyderabad, India.

Purpose: To study the efficacy of interferon alfa-2b (IFN-a2b) on pigmented ocular surface squamous neoplasia (p-OSSN) and assess the resolution of the pigment to the treatment.

Methods: A retrospective case series of 8 tumors in 7 patients.

Results: The mean age at diagnosis of p-OSSN was 65 years (median, 61 years; range, 51-84 years), and all patients were men. Read More

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http://dx.doi.org/10.1097/ICO.0000000000002350DOI Listing

Differential diagnosis and management of melanocytic lesions of the ocular surface

Orv Hetil 2020 04 1;161(15):563-574. Epub 2020 Apr 1.

Semmelweis Egyetem, Budapest, Mária u. 39., 1085.

Our purpose is to summarize the actual knowledge about melanocytic lesions of the ocular surface (conjunctival nevus, primary acquired melanosis and conjunctival melanoma),especially their clinical appearance, differential diagnosis and treatment. Conjunctival nevus is the most common benign, conjunctival melanocytic lesion. Primary acquired melanosis mainly presents in middle-aged or elderly individuals, characterized by proliferation of melanocytes of the conjunctival epithelial layer. Read More

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http://dx.doi.org/10.1556/650.2020.31699DOI Listing

Serial F-FDG PET/CT findings in a patient with neurocutaneous melanosis.

Neurol Clin Pract 2020 Apr;10(2):e14-e16

Department of Pediatrics (YD, XS) and Department of Nuclear Medicine (WZ), the Affiliated Hospital of Southwest Medical University; and Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province (WZ), Luzhou, Sichuan, China.

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http://dx.doi.org/10.1212/CPJ.0000000000000700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156200PMC

Epilepsy in isolated parenchymal neurocutaneous melanosis: A systematic review.

Epilepsy Behav 2020 Jun 6;107:107061. Epub 2020 Apr 6.

Section of Pediatrics, Department of Medical Sciences, University of Ferrara, University Hospital Arcispedale Sant'Anna, Ferrara, Italy.

Purpose: Neurocutaneous melanosis (NCM) is a rare congenital syndrome characterized by giant melanocytic cutaneous nevi and melanosis within the central nervous system (CNS), often sparing leptomeninges and concentrated in the brain parenchyma. Epilepsy and neurodevelopmental abnormalities are the only complications reported in children with isolated parenchymal melanosis. A minority of patients experience drug-resistant epilepsy, and up to now, no predictors of epilepsy prognosis have been identified. Read More

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http://dx.doi.org/10.1016/j.yebeh.2020.107061DOI Listing

[A woman with a skin lesion suspected for melanoma].

Ned Tijdschr Geneeskd 2020 Feb 27;164. Epub 2020 Feb 27.

Antoni van Leeuwenhoekziekenhuis, afd. Dermatologie, Amsterdam.

We saw a 59-year-old patient who was treated with dabrafenib and trametinib because of metastatic melanoma. She had an asymptomatic, black-blue macula in the excision scar. Histopathology showed tumoral melanosis. Read More

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February 2020

Melanonychia associated with subungual follicular inclusions: report of three cases.

An Bras Dermatol 2020 Mar - Apr;95(2):217-220. Epub 2020 Feb 12.

Dermatology Service, Hospital Universitário Pedro Ernesto, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

Melanonychia is the change in the coloration of the nail plate resulting from the deposition of melanin. Among its causes are melanocytic hyperplasia, melanocytic activation and nail melanoma. Subungual follicular inclusions are histological findings of unknown etiology, possibly related to trauma. Read More

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http://dx.doi.org/10.1016/j.abd.2019.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175037PMC

Tumoral Melanosis in the Setting of Targeted Immunotherapy for Metastatic Melanoma-A Single Institutional Experience and Literature Review.

Am J Dermatopathol 2020 Mar 6. Epub 2020 Mar 6.

Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.

Background: Tumoral melanosis clinically resembles metastatic melanoma, occurs in the context of regressed disease, and requires evaluation to rule out underlying melanoma and metastatic disease. Histopathology demonstrates a nodular infiltrate of melanophages in the dermis, subcutaneous tissue, deep soft tissue, or lymph nodes in the absence of viable melanocytes. Recent limited reports of tumoral melanosis in the context of immunotherapy with ipilimumab (monoclonal antibody targeting CTLA-4) as well as nivolumab and pembrolizumab (humanized monoclonal antibodies against programmed death 1 receptor) highlight a unique presentation representative of treatment-related tumor regression and an association with a favorable clinical response. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001612DOI Listing

Conjunctival melanoma in an African American man.

Am J Ophthalmol Case Rep 2020 Jun 26;18:100641. Epub 2020 Feb 26.

University of Illinois at Chicago, Department of Ophthalmology and Visual Sciences, Chicago, IL, USA.

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http://dx.doi.org/10.1016/j.ajoc.2020.100641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049596PMC

Conjunctival Melanoma: Features and Outcomes Based on the Fitzpatrick Skin Type in 540 Patients at a Single Ocular Oncology Center.

Ophthalmic Plast Reconstr Surg 2020 Mar 2. Epub 2020 Mar 2.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, U.S.A.

Purpose: To determine the association of Fitzpatrick skin type (FST) with conjunctival melanoma.

Methods: Retrospective case series of 540 patients with conjunctival melanoma to assess clinical features and outcomes per FST.

Results: The FST was Type I (n = 126, 23%), II (n = 337, 62%), III (n = 56, 10%), IV (n = 8, 2%), V (n = 12, 2%), and VI (n = 1, <1%). Read More

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http://dx.doi.org/10.1097/IOP.0000000000001624DOI Listing

Melanogenic Properties and Expression Profiles of Melanogenic Paracrine Molecules in Riehl's Melanosis.

Int J Mol Sci 2020 Mar 2;21(5). Epub 2020 Mar 2.

Department of Dermatology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 07345, Korea.

Riehl's melanosis is a hyperpigmentary disorder that occurs predominantly on the face and neck. To date, the pathogenesis of Riehl's melanosis with regards to the melanogenic properties and paracrine melanogenic molecules has not well been studied. This study was aimed to provide a novel perspective on the pathogenesis of Riehl's melanosis by identifying the relevant paracrine melanogenic molecules in Riehl's melanosis. Read More

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http://dx.doi.org/10.3390/ijms21051695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084821PMC

Melanosis coli: A comprehensive review.

Gastroenterol Hepatol 2020 May 21;43(5):266-272. Epub 2020 Feb 21.

Department of Gastroenterology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address:

Melanosis coli (MC) is a common condition characterized by a black or brown pigment deposited in the colorectal mucosa. It is a reversible condition that is influenced by many factors, such as living habits and bowel function. However, the epidemiology and etiology of MC are still unclear. Read More

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http://dx.doi.org/10.1016/j.gastrohep.2020.01.002DOI Listing

Benign tumoral melanosis of a cervical lymph node in a child.

Int J Pediatr Otorhinolaryngol 2020 Jan 30;132:109916. Epub 2020 Jan 30.

Department of Otolaryngology, Children's Hospital Colorado, 12631 E. 17th Ave., B-205, Aurora, CO, 80045, USA.

We present a pediatric case of benign tumoral melanosis in a cervical lymph node arising from congenital pigmented lesions of the anterior neck. This is the first reported pediatric case not associated with regressed melanoma or trauma. Tumoral melanosis is a rare phenomenon which describes a pigmented lesion like melanoma; however, histology demonstrates melanin-laden macrophages without malignant cells. Read More

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http://dx.doi.org/10.1016/j.ijporl.2020.109916DOI Listing
January 2020

Primary pigmented meningeal melanocytoma originating in Meckel cave in a patient with carney complex: A case report.

Medicine (Baltimore) 2020 Jan;99(3):e18783

Neurosurgery Department, Imam Abdulrahman Bin Faisal University, King Fahd Hospital of the University, Saudi Arabia.

Rationale: Primary melanin-producing tumors are rare extra-axial neoplasms OPEN of the central nervous system. In the literature, few case reports have discussed neoplasms involving the cavernous sinus; of these, only 4 have reported on neoplasms originating in Meckel cave. The diagnostic approach, including clinical and radiological analysis, is challenging, and cytopathological assessment with a molecular basis is the best approach to discriminate between these lesions. Read More

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http://dx.doi.org/10.1097/MD.0000000000018783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220446PMC
January 2020

Global Prevalence of Tobacco Use in Adolescents and Its Adverse Oral Health Consequences.

Open Access Maced J Med Sci 2019 Nov 11;7(21):3659-3666. Epub 2019 Oct 11.

Department of Preventive Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

Background: Smoking is associated with various systemic conditions and contributes to a huge financial burden to economies around the world.

Aim: The study aimed to evaluate global data about the prevalence of tobacco use among male and female adolescents and to discuss smoking-related oral complications.

Methods: The prevalence data of tobacco use among adolescents (13-15 years) was retrieved from the World Health Organization (Global Health Observatory). Read More

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http://dx.doi.org/10.3889/oamjms.2019.542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986508PMC
November 2019

Histopathological Features of Riehl Melanosis.

Am J Dermatopathol 2020 Feb;42(2):117-121

Department of Dermatology, Ajou University School of Medicine, Suwon, Korea.

Histological features of Riehl melanosis have rarely been compared between lesional and perilesional normal skin and have not been precisely described using quantitative or immunohistochemical analysis or electron microscopic findings. To investigate the histopathological and immunohistochemical features of lesional and perilesional normal skin of patients with Riehl melanosis, we retrospectively evaluated the electronic medical records and skin biopsy specimens of 48 patients with Riehl melanosis. In addition, electron microscopy was performed on 1 case. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001515DOI Listing
February 2020

Association between anthraquinone laxatives and colorectal cancer: protocol for a systematic review and meta-analysis.

Syst Rev 2020 01 24;9(1):19. Epub 2020 Jan 24.

Research and Innovation Center in Phytotherapy and Integrated Medicine CERFIT, Referring Center for Phytotherapy, Tuscany Region, Careggi University Hospital, Florence, Italy.

Introduction: Products containing anthraquinones (AQ) are mainly used as laxatives and have several biological effects. Long-term use of AQ laxatives is associated with an increased risk of serious adverse events (AEs), such as colorectal cancer (CRC). We will systematically synthesize the evidence on the potential association between the use of AQ laxatives and the risk of CRC. Read More

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http://dx.doi.org/10.1186/s13643-020-1280-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6979293PMC
January 2020

Successful Treatment of Riehl's Melanosis With Mid-Fluence Q-Switched Nd:YAG 1064-nm Laser.

Lasers Surg Med 2020 Jan 17. Epub 2020 Jan 17.

Department of Dermatology, Gangnam Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, 211 Eonjuro, Gangnam-gu, Seoul, 06273, Korea.

Background And Objectives: Riehl's melanosis is a chronic acquired hyperpigmentation disorder that causes significant cosmetic problems for patients with this condition. Several treatment options, including low-fluence Q-switched Nd:YAG (QSNY) 1064-nm laser treatment, have been attempted with inconsistent results. We aimed to investigate the beneficial effect of mid-fluence QSNY 1064-nm laser in the treatment of Riehl's melanosis. Read More

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http://dx.doi.org/10.1002/lsm.23214DOI Listing
January 2020

Ferulic acid 12% peel: An innovative peel for constitutional type of periorbital melanosis-Comparing clinical efficacy and safety with 20% glycolic peel and 15% lactic peel.

J Cosmet Dermatol 2020 Jan 16. Epub 2020 Jan 16.

Department of Dermatology, Venereology and Leprology, Pt B. D. Sharma, University of Health Sciences, Rohtak, Haryana, India.

Background: Periorbital hyperpigmentation (POH) is a very common, yet unexplored aesthetic condition. Topical therapy is mainstay of treatment which includes chemical peels and other depigmenting agents.

Aims: To compare clinical efficacy, safety, and tolerability of 20% glycolic acid peels, 15% lactic acid peels, and 12% ferulic acid peels in the treatment of constitutional type of periorbital hyperpigmentation in Indian patients. Read More

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http://dx.doi.org/10.1111/jocd.13292DOI Listing
January 2020

A pigmented lesion on the eye.

BMJ 2020 01 9;368:l6810. Epub 2020 Jan 9.

Department of Ophthalmology & Visual Sciences, W K Kellogg Eye Center, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1136/bmj.l6810DOI Listing
January 2020

Outcomes and measurement instruments used in congenital melanocytic naevi research: A systematic review.

J Plast Reconstr Aesthet Surg 2020 Apr 28;73(4):703-715. Epub 2019 Nov 28.

Department of Dermatology, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands.

Background: Congenital melanocytic naevi (CMN) can have a great impact on patients' lives due to the remarkable appearance and the risk of developing melanoma and neurocutaneous melanosis. Comparison of treatment efficacy is currently hindered by the lack of standard and uniform outcome reporting; this impedes guidance on optimal management policy. To address this, we aim to perform the first step in developing a core outcome set. Read More

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http://dx.doi.org/10.1016/j.bjps.2019.11.023DOI Listing

Inhibition of melanosis and microbial growth in Pacific white shrimp (Litopenaeus vannamei) using high CO modified atmosphere packaging.

Food Chem 2020 May 26;312:126114. Epub 2019 Dec 26.

Department of Packaging and Materials Technology, Faculty of Agro-Industry, Kasetsart University, Bangkok 10900, Thailand; Center for Advanced Studies for Agriculture and Food, Kasetsart University, Bangkok 10900, Thailand. Electronic address:

Preserving quality of crustaceans requires efficient modified atmosphere packaging (MAP). Effects of CO (20%-80%) on quality and melanosis in chilled Pacific white shrimp (Litopenaeus vannamei) under O concentrations of 5 and 15% were investigated. Increased headspace CO and lipid oxidation contributed to loss of firmness due to protein degradation. Read More

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http://dx.doi.org/10.1016/j.foodchem.2019.126114DOI Listing

Standardization of organoid culture for evaluation of melanogenesis induced by UVB, UVA and visible light.

An Bras Dermatol 2020 Jan - Feb;95(1):46-51. Epub 2019 Dec 6.

Department of Dermatology and Radiotherapy, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu, SP, Brazil. Electronic address:

Background: Organoid cultures are primary cultures that maintain architectural characteristics and the relationships between cells, as well as the extracellular matrix. They are alternatives for pathophysiological or therapeutic investigation rather than animal and in vitro tests.

Objective: Development of a cutaneous organoid culture model, aiming at the study of radiation-induced melanogenesis. Read More

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http://dx.doi.org/10.1016/j.abd.2019.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058865PMC

The color of skin: brown diseases of the skin, nails, and mucosa.

Clin Dermatol 2019 Sep - Oct;37(5):487-506. Epub 2019 Jul 23.

Department of Dermatology, Cerrahpaşa Medical Faculty, Istanbul University-Cerrahpaşa, Istanbul, Turkey.

Brown diseases comprise disorders leading to hyperpigmentation in skin and nails. Melasma is an acquired skin disorder that is characterized by brownish macules that typically occur on the face. Schamberg disease, also known as progressive pigmented purpura, is characterized by brown pigmentation with pepper spots on their edges. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2019.07.007DOI Listing

The color of skin: black diseases of the skin, nails, and mucosa.

Clin Dermatol 2019 Sep - Oct;37(5):447-467. Epub 2019 Aug 17.

Department of Dermatology, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania, USA.

Gradations in skin color are a consequence of differing amounts of melanin and their varying distribution. Although many darkly pigmented skin lesions are melanocytic and can be attributed to melanin content, the color of a black lesion can also be due to blood, necrotic tissue, or exogenous pigment. The source, pattern, and distribution of the color in black lesions usually offer important insight into its etiology. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2019.08.003DOI Listing

Lifetime UVR Dose and Skin Cancer Risk, Determined by Their Common Relation to Solar Lentigines.

Anticancer Res 2020 Jan;40(1):557-564

Department of Dermatology, Research Department D92, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.

Background/aim: Ultraviolet radiation (UVR) causes solar lentigines (SL) and skin cancer (SC) in humans. The association between measured lifetime UVR dose and SC has not been investigated. This study investigated this relation through their common relationship to SL. Read More

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http://dx.doi.org/10.21873/anticanres.13985DOI Listing
January 2020

Oncologic and visual outcomes after postoperative proton therapy of localized conjunctival melanomas.

Radiat Oncol 2019 Dec 27;14(1):239. Epub 2019 Dec 27.

Department of Ophthalmology, Pasteur 2 Teaching Hospital, Nice, France.

Introduction: conjunctival melanomas have high local relapse rates. Oncologic and visual outcomes can be improved with proton therapy and no-touch surgery.

Material And Methods: a monocentric retrospective study of consecutive patients treated with surgery and proton therapy for conjunctival melanoma was conducted. Read More

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http://dx.doi.org/10.1186/s13014-019-1426-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935064PMC
December 2019

The Role of Stem Cell Factor in Hyperpigmented Skin Lesions.

Asian Pac J Cancer Prev 2019 Dec 1;20(12):3723-3728. Epub 2019 Dec 1.

Department of Pharmacology, Faculty of Medicine, Tanta University, Tanta, Egypt.

Background: Skin hyperpigmentation usually results from an increased number, or activity, of melanocytes. The degree of pigmentation of skin depends on the amount and type of melanin, degree of skin vascularity, presence of carotene, and thickness of the stratum corneum. Common causes of hyperpigmentation include post-inflammatory hyperpigmentation, melasma, solar lentigines, ephelides (freckles), and café-au-lait macules. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.12.3723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173358PMC
December 2019

Esophageal melanosis with eosinophilic esophagitis.

Gastrointest Endosc 2020 May 18;91(5):1203-1204. Epub 2019 Dec 18.

Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.

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http://dx.doi.org/10.1016/j.gie.2019.12.006DOI Listing

Immunohistochemical analysis of benign and malignant melanocytic lesions of the conjunctiva using double-staining.

Can J Ophthalmol 2019 12 14;54(6):699-707. Epub 2019 Jun 14.

Department of Ophthalmology, The Ottawa Hospital, University of Ottawa, Ottawa, Ont.; Department of Pathology, The Ottawa Hospital, University of Ottawa, Ottawa, Ont.

Objective: To implement a double-staining technique to identify the most sensitive and specific combinations of melanoma antigen recognized by T cells (Melan-A), microphthalmia-associated transcription factor (MITF), human melanoma black 45 (HMB45), and Ki67 aiming to assist in the diagnosis of atypical melanocytic conjunctival lesions that are more prone to malignant progression.

Methods: Eight specimens of conjunctival melanoma and of primary acquired melanosis with moderate to severe atypia were double-immunostained with a combination of a cytoplasmic marker (anti-Melan-A or anti-HMB45), and a nuclear marker (anti-MITF or anti-Ki67). Eight specimens of normal conjunctiva and of conjunctival nevi served as controls. Read More

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http://dx.doi.org/10.1016/j.jcjo.2019.03.015DOI Listing
December 2019

[Peutz-Jeghers syndrome and cancer:a retrospective study in 14 Japanese patients with Peutz-Jeghers syndrome].

Nihon Shokakibyo Gakkai Zasshi 2019 ;116(12):1015-1021

Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences.

We retrospectively investigated 14 Japanese patients with Peutz-Jeghers (PJ) syndrome who were treated in six hospitals to determine the prevalence of cancer in Japanese patients with PJ syndrome. The study included seven males and seven females. The mean age at the time of diagnosis of PJ syndrome was 28. Read More

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http://dx.doi.org/10.11405/nisshoshi.116.1015DOI Listing
December 2019

Retrospective study on melanosis coli as risk factor of colorectal neoplasm: a 3-year colonoscopic finding in Zhuhai Hospital, China.

Int J Colorectal Dis 2020 Feb 10;35(2):213-222. Epub 2019 Dec 10.

Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, China.

Background: Melanosis coli (MC) is a colonoscopic finding in which the colonic mucosa appears darkly pigmented than usual and generally caused by extended anthranoid laxative use.

Methods: We performed a retrospective study at Zhuhai Hospital to investigate the risk of MC for CR neoplasm development. A total of 12,776 patients who underwent colonoscopy from 2013 to 2016 including 250 diagnosed with MC and 500 controls were included in this study. Read More

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http://dx.doi.org/10.1007/s00384-019-03435-7DOI Listing
February 2020

Formula optimization for melanosis-inhibitors of Pacific white shrimp () by response surface methodology.

Food Sci Biotechnol 2019 Dec 27;28(6):1687-1692. Epub 2019 Apr 27.

Shanghai Engineering Research Center of Aquatic Product Processing and Preservation, College of Food Science and Technology, Shanghai Ocean University, No. 999 Huchenghuan Road, Pudong District, Shanghai, 201306 People's Republic of China.

Melanosis is major problem of crustaceans during their rigor mortis storage. This study for the first time was designed to optimize the formula of preservatives to maintain the color feature of Pacific white shrimp using response surface methodology. A three-factors-three-levels Box-Behnken design was applied to evaluate the effect of chitosan, citric acid and l-cysteine on color features (, , and ) of Pacific white shrimp. Read More

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http://dx.doi.org/10.1007/s10068-019-00612-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859178PMC
December 2019
0.656 Impact Factor

Oral manifestation in leprosy: A cross-sectional study of 100 cases with literature review.

J Family Med Prim Care 2019 Nov 15;8(11):3689-3694. Epub 2019 Nov 15.

Department of OMFS, Maharaja Ganga Singh Dental College and Research Centre, 11 L.N.P, Hanumangarh Rd, Sri Ganganagar, Rajasthan, India.

Background: Leprosy is a chronic granulomatous disease of the peripheral nerve and muscle of upper respiratory tract. Consequence to the neighboring primary site, oral lesions have been seen in 20--60% of patient with leprosy mainly lepromatous leprosy. The lepromatous nodules may be infective and may lead to the spread of disease and hence require proper diagnosis. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_766_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881956PMC
November 2019

Peutz-Jeghers syndrome complicated with intussusception in late pregnancy.

Lancet Oncol 2019 12;20(12):e729

Department of Gastrointestinal Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, China.

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http://dx.doi.org/10.1016/S1470-2045(19)30692-8DOI Listing
December 2019

Conjunctival pigmented lesion: Clinicopathological analysis of 85 cases in Korean population.

Sci Rep 2019 12 3;9(1):18204. Epub 2019 Dec 3.

Department of Ophthalmology, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, 03080, Korea.

To evaluate histopathological characteristics of conjunctival pigmented lesions and analyze clinical features related to histologic classification in Asian population, we analyzed medical records, anterior segment photographs, and histological specimen of 85 eyes who had undergone biopsy for pigmented conjunctival lesions at Seoul National University Hospital between 1999 and 2018. Compound nevus was the most common type of conjunctival pigmented lesions (67.1%), followed by conjunctival melanocytic intraepithelial neoplasia (primary acquired melanosis)(11. Read More

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http://dx.doi.org/10.1038/s41598-019-54786-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890774PMC
December 2019

Guidelines for the management of hereditary colorectal cancer from the British Society of Gastroenterology (BSG)/Association of Coloproctology of Great Britain and Ireland (ACPGBI)/United Kingdom Cancer Genetics Group (UKCGG).

Gut 2020 03 28;69(3):411-444. Epub 2019 Nov 28.

Genetic Medicine, Central Manchester University Hospitals Foundation Trust, Manchester, UK.

Heritable factors account for approximately 35% of colorectal cancer (CRC) risk, and almost 30% of the population in the UK have a family history of CRC. The quantification of an individual's lifetime risk of gastrointestinal cancer may incorporate clinical and molecular data, and depends on accurate phenotypic assessment and genetic diagnosis. In turn this may facilitate targeted risk-reducing interventions, including endoscopic surveillance, preventative surgery and chemoprophylaxis, which provide opportunities for cancer prevention. Read More

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http://dx.doi.org/10.1136/gutjnl-2019-319915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034349PMC

Is There a Correlation between Severity of Melasma and Quality of Life?

Open Access Maced J Med Sci 2019 Aug 25;7(16):2615-2618. Epub 2019 Aug 25.

Department of Dermatology and Venerology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.

Background: Melasma is a common chronic acquired hyper melanosis. It has significant impacts on appearance, psychosocial and emotional distress, hence reducing the quality of life of the affected patients. Melasma quality of life scale (MelasQoL) is a new quality of life (QoL) questionnaire consists of 10 questions, scored from 1 to 7, with higher index scores indicating poor QoL. Read More

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http://dx.doi.org/10.3889/oamjms.2019.407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876811PMC