325 results match your criteria Ependymoma* Neurology


Influence of pregnancy on glioma patients.

Acta Neurochir (Wien) 2019 Jan 29. Epub 2019 Jan 29.

Department of Neurosurgery, Goethe University Hospital, Schleusenweg 2-16, 60528, Frankfurt am Main, Germany.

Background: Data about the influence of pregnancy on progression-free survival and overall survival of glioma patients are sparse and controversial. We aimed at providing further evidence on this relation.

Methods: The course of 18 glioma patients giving birth to 23 children after tumor surgery was reviewed and compared to the course of 18 nulliparous female patients matched for tumor diagnosis including molecular markers, extent of resection, and tumor location. Read More

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http://dx.doi.org/10.1007/s00701-019-03823-6DOI Listing
January 2019
1 Read

A novel type of C11orf95-LOC-RELA fusion in a grade II supratentorial ependymoma: report of a case with literature review.

Childs Nerv Syst 2019 Jan 10. Epub 2019 Jan 10.

Departments of Pediatrics, Ribeirão Preto Medical of School, University of São Paulo, Ribeirão Preto, SP, Brazil.

Background: Ependymoma (EPN) is the third most common central nervous system tumor in childhood. Recent advances in the molecular classification of EPN revealed a supratentorial (ST) ependymoma subgroup characterized by C11orf95-RELA fusion.

Case Report: We describe a novel RELA-fusion composed by a chimeric transcript C11orf95-LOC-RELA in a supratentorial WHO grade II EPN occurring in a 4-year-old child. Read More

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http://dx.doi.org/10.1007/s00381-018-04028-5DOI Listing
January 2019
1 Read

High frequency of H3 K27M mutations in adult midline gliomas.

J Cancer Res Clin Oncol 2019 Jan 4. Epub 2019 Jan 4.

Department of Neuropathology, Institute of Pathology and Neuropathology, University Hospital of Tuebingen, Eberhard Karls University of Tuebingen, 72076, Tuebingen, Germany.

Purpose: Diffuse midline gliomas, H3 K27M-mutant were introduced as a new grade IV entity in WHO classification of tumors 2016. These tumors occur often in pediatric patients and show an adverse prognosis with a median survival less than a year. Most of the studies on these tumors, previously known as pediatric diffuse intrinsic pontine glioma, are on pediatric patients and its significance in adult patients is likely underestimated. Read More

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http://link.springer.com/10.1007/s00432-018-02836-5
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http://dx.doi.org/10.1007/s00432-018-02836-5DOI Listing
January 2019
15 Reads

Identifying the deficiencies of current diagnostic criteria for neurofibromatosis 2 using databases of 2777 individuals with molecular testing.

Genet Med 2018 Dec 7. Epub 2018 Dec 7.

Department of Genomic Medicine, St Mary's Hospital, Manchester Academic Health Sciences Centre (MAHSC), Division of Evolution and Genomic Science, University of Manchester, Manchester, UK.

Purpose: We have evaluated deficiencies in existing diagnostic criteria for neurofibromatosis 2 (NF2).

Methods: Two large databases of individuals fulfilling NF2 criteria (n = 1361) and those tested for NF2 variants with criteria short of diagnosis (n = 1416) were interrogated. We assessed the proportions meeting each diagnostic criterion with constitutional or mosaic NF2 variants and the positive predictive value (PPV) with regard to definite diagnosis. Read More

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http://dx.doi.org/10.1038/s41436-018-0384-yDOI Listing
December 2018
3 Reads
7.329 Impact Factor

Unusual features of ependymoma in a patient with Parkinson's disease.

J Clin Neurosci 2019 Jan 6;59:310-312. Epub 2018 Nov 6.

Department of Pathology and Molecular Medicine/Neuropathology, McMaster University, Hamilton, Ontario, Canada. Electronic address:

The diagnosis and management of ependymoma may be challenging when there is a comorbidity of ependymoma and Parkinson's disease (PD). We report the first case to demonstrate unusual clinical and pathological features of an ependymoma associated with PD. A 77-year-old male with a history of PD had brain magnetic resonance imaging (MRI) that showed signal abnormalities in the right temporal lobe, most consistent with a low-grade glioma. Read More

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http://dx.doi.org/10.1016/j.jocn.2018.10.124DOI Listing
January 2019
7 Reads

Surgical Management of Isolated Fourth Ventricular Hydrocephalus Associated with Injury to the Guillain-Mollaret Triangle.

World Neurosurg 2019 Feb 25;122:71-76. Epub 2018 Oct 25.

Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada. Electronic address:

Background: The occurrence of isolated fourth ventricle and injury to the Guillain-Mollaret triangle in the setting of posterior fossa ependymoma represents a new association. In this case report, we discuss the clinical, theoretical, and therapeutic aspects of this problem. We describe a lateral transcerebellar trajectory and shunt valve configuration for safe fourth ventricle shunting in a patient with prior posterior fossa surgery. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183238
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http://dx.doi.org/10.1016/j.wneu.2018.10.091DOI Listing
February 2019
10 Reads

Pediatric Spinal Ependymomas.

Med Sci Monit 2018 Oct 5;24:7072-7089. Epub 2018 Oct 5.

Department of Neurosurgery, Bezmialem Vakif University, Istanbul, Turkey.

BACKGROUND The aim of this study was to assess the clinical and radiological outcomes of surgical treatment for primary spinal ependymoma in children. MATERIAL AND METHODS Medical records of 46 primary spinal ependymoma patients who underwent surgery in BRSHH hospital during a 12-year period from 2004 to 2015 were retrospectively reviewed. All pediatric patients (patient age <18 years) were selected as the core sample used for this study. Read More

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https://www.medscimonit.com/abstract/index/idArt/910447
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http://dx.doi.org/10.12659/MSM.910447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186154PMC
October 2018
5 Reads

Childhood supratentorial ependymomas with YAP1-MAMLD1 fusion: an entity with characteristic clinical, radiological, cytogenetic and histopathological features.

Brain Pathol 2018 Sep 23. Epub 2018 Sep 23.

Institute of Neuropathology, University of Bonn Medical Center, Bonn, Germany.

Ependymoma with YAP1-MAMLD1 fusion is a rare, recently described supratentorial neoplasm of childhood, with few cases published so far. We report on 15 pediatric patients with ependymomas carrying YAP1-MAMLD1 fusions, with their characteristic histopathology, immunophenotype and molecular/cytogenetic, radiological and clinical features. The YAP1-MAMLD1 fusion was documented by RT-PCR/Sanger sequencing, and tumor genomes were studied by molecular inversion probe (MIP) analysis. Read More

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http://dx.doi.org/10.1111/bpa.12659DOI Listing
September 2018
19 Reads

Pediatric Case of Li-Fraumeni Syndrome Complicated with Supratentorial Anaplastic Ependymoma.

World Neurosurg 2018 Dec 6;120:125-128. Epub 2018 Sep 6.

Division of Neurosurgery, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University, Yonago, Tottori, Japan.

Background: Li-Fraumeni syndrome is a genetic disease that is caused by mutation of the tumor suppressor gene TP53. Patients with this syndrome may develop multiple malignant neoplasms including brain tumors. We herein report the first case of Li-Fraumeni syndrome in which development of supratentorial anaplastic ependymoma led to difficulty in terms of selecting the optimal postoperative therapeutic protocol. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183198
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http://dx.doi.org/10.1016/j.wneu.2018.08.203DOI Listing
December 2018
18 Reads

Rare but Recurrent ROS1 Fusions Resulting From Chromosome 6q22 Microdeletions are Targetable Oncogenes in Glioma.

Clin Cancer Res 2018 Dec 31;24(24):6471-6482. Epub 2018 Aug 31.

Knight Cancer Institute, Oregon Health and Sciences University, Portland, Oregon.

Purpose: Gliomas, a genetically heterogeneous group of primary central nervous system tumors, continue to pose a significant clinical challenge. Discovery of chromosomal rearrangements involving kinase genes has enabled precision therapy, and improved outcomes in several malignancies.

Experimental Design: Positing that similar benefit could be accomplished for patients with brain cancer, we evaluated The Cancer Genome Atlas (TCGA) glioblastoma dataset. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-1052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295214PMC
December 2018
6 Reads
8.722 Impact Factor

Differential diagnosis of posterior fossa tumours in children: new insights.

Pediatr Radiol 2018 12 17;48(13):1955-1963. Epub 2018 Aug 17.

Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, UK.

Central nervous system neoplasms are the most common solid tumours that develop in children, with the greatest proportion located in the infratentorium. The 2016 World Health Organization Central Nervous System tumour classification evolved from the 2007 edition with the integration of molecular and genetic profiling into the diagnosis, the addition of new entities and the removal of others. Radiology can assist with the subtyping of tumours from certain characteristics described below to provide prognostic information and guide further management. Read More

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http://link.springer.com/10.1007/s00247-018-4224-7
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http://dx.doi.org/10.1007/s00247-018-4224-7DOI Listing
December 2018
23 Reads

Fourth ventricle ependymoma mimicking benign paroxysmal positional vertigo.

Neurology 2018 Aug;91(7):327-328

From the Balance Disorders and Ataxia Service (L.P., D.J.S.), The Royal Victorian Eye and Ear Hospital; Florey Institute of Neuroscience and Mental Health (L.P., D.J.S.); Dizzy Day Clinics (L.P., K.M.); Department of Neurosurgery (K.J.D.), Royal Melbourne Hospital; Department of Surgery (K.J.D.), University of Melbourne; Medical Imaging Department (N.T.), St Vincents Hospital; and Cerebellar Ataxia Clinic (D.J.S.), Neuroscience Department, Alfred Health, Melbourne, Australia.

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http://dx.doi.org/10.1212/WNL.0000000000005992DOI Listing
August 2018
11 Reads

DNA methylation-based classification of ependymomas in adulthood: implications for diagnosis and treatment.

Neuro Oncol 2018 Nov;20(12):1616-1624

Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland.

Background: Ependymal tumors are glial tumors that commonly manifest in children and young adults. Their classification has remained entirely morphological until recently, and surgery and radiotherapy are the main treatment options, especially in adults. Here we sought to correlate DNA methylation profiles with clinical and pathological characteristics in the prospective cohort of the German Glioma Network. Read More

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http://dx.doi.org/10.1093/neuonc/noy118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231197PMC
November 2018
6 Reads

Heterogeneity within the PF-EPN-B ependymoma subgroup.

Acta Neuropathol 2018 Aug 17;136(2):227-237. Epub 2018 Jul 17.

Programme in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada.

Posterior fossa ependymoma comprise three distinct molecular variants, termed PF-EPN-A (PFA), PF-EPN-B (PFB), and PF-EPN-SE (subependymoma). Clinically, they are very disparate and PFB tumors are currently being considered for a trial of radiation avoidance. However, to move forward, unraveling the heterogeneity within PFB would be highly desirable. Read More

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http://link.springer.com/10.1007/s00401-018-1888-x
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http://dx.doi.org/10.1007/s00401-018-1888-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373486PMC
August 2018
15 Reads
10.762 Impact Factor

Severe Nightly Thoracic Pain Presenting during Pregnancy: A Case Report.

Case Rep Neurol 2018 May-Aug;10(2):135-139. Epub 2018 Jun 7.

Department of Neurology, Leiden University/Hagaziekenhuis, Leiden / The Hague, the Netherlands.

We present the case of a woman who developed severe nightly thoracic pain during pregnancy without neurological deficits upon examination. Spontaneously after childbirth, the pain was markedly reduced. Further investigation showed that her pain was caused by an ependymoma in the cervicothoracic spinal cord. Read More

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http://dx.doi.org/10.1159/000488756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031941PMC
June 2018
17 Reads

Outcomes in children with central nervous system tumors disseminated at presentation: a large single-center experience.

Childs Nerv Syst 2018 Jun 24. Epub 2018 Jun 24.

Department of Neurosurgery, Great Ormond Street Hospital for Children NHS Trust, London, WC1N 3JH, UK.

Purpose: Children with disseminated central nervous system (CNS) tumors have worse outcomes than those with solitary disease, but outcomes of disease dissemination at initial presentation have not been systematically studied and compared across tumor groups to date. We evaluated the impact of tumor dissemination at presentation on management and clinical outcomes in a cohort of consecutively treated children in a single neurosurgical unit over a 14-year period.

Methods: Method used was a retrospective review of data on children presenting to Great Ormond Street Hospital, London, UK, with medulloblastoma, primitive neuroectodermal tumor, atypical teratoid rhabdoid tumor, pilocytic astrocytoma, and ependymoma between 2003 and 2016 inclusive. Read More

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http://dx.doi.org/10.1007/s00381-018-3871-1DOI Listing
June 2018
10 Reads

Subependymomas - Characteristics of a "Leave me Alone" Lesion.

Rofo 2018 10 18;190(10):955-966. Epub 2018 Jun 18.

Goethe-University, Institute for Neuroradiology, Frankfurt, Germany.

Purpose: Intracranial subependymomas are rare, mostly asymptomatic tumours, which are often found incidentally and therefore did not receive much attention in previous literature. By being classified as benign grade I in the WHO classification of tumours of the central nervous system, they are given a special status compared to the other ependymal tumours. Tumor recurrences are a rarity, spinal "drop metastases" do not occur. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0576-1028
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http://dx.doi.org/10.1055/a-0576-1028DOI Listing
October 2018
21 Reads

Extensive Cranial Nerves Involvement in Neurofibromatosis: A Rare Presentation.

J Pediatr Neurosci 2018 Jan-Mar;13(1):74-77

Department of Neurology, Institute of Human Behaviour and Allied Sciences (IHBAS), New Delhi, India.

Neurofibromatosis type 2 is a rare neurocutaneous syndrome characterized by the development of multiple nervous system tumors. This disorder is also called multiple inherited schwannomas, meningiomas, and ependymomas syndrome. In this report, we discuss the clinical and magnetic resonance imaging findings in a 17-year-old patient with neurofibromatosis type 2, who had extensive cranial nerves involvement (3rd-12th cranial nerves) along with spinal involvement. Read More

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http://dx.doi.org/10.4103/JPN.JPN_32_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5982496PMC
June 2018
6 Reads

Establishment of primary cell culture and an intracranial xenograft model of pediatric ependymoma: a prospect for therapy development and understanding of tumor biology.

Oncotarget 2018 Apr 24;9(31):21731-21743. Epub 2018 Apr 24.

Department of Neurology and Neurosurgery, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.

Background: Ependymoma (EPN), the third most common pediatric brain tumor, is a central nervous system (CNS) malignancy originating from the walls of the ventricular system. Surgical resection followed by radiation therapy has been the primary treatment for most pediatric intracranial EPNs. Despite numerous studies into the prognostic value of histological classification, the extent of surgical resection and adjuvant radiotherapy, there have been relatively few studies into the molecular and cellular biology of EPNs. Read More

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http://dx.doi.org/10.18632/oncotarget.24932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955158PMC
April 2018
18 Reads

Giant Cell Ependymoma of Cervicomedullary Junction: A Case Report of a Long-Term Survivor and Literature Review.

World Neurosurg 2018 Aug 14;116:121-126. Epub 2018 May 14.

Division of Neurosurgery, Department of Neurology and Psychiatry, "Sapienza" University of Rome, Rome, Italy.

Background: Ependymoma accounts for 3%-9% of all neuroepithelial tumors. Giant cell ependymoma (GCE) is a rare and distinct variant, with only 22 cases described in the literature. The 2007 World Health Organization classification first acknowledged this rare subtype. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183099
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http://dx.doi.org/10.1016/j.wneu.2018.05.040DOI Listing
August 2018
26 Reads

2016 Children's Tumor Foundation conference on neurofibromatosis type 1, neurofibromatosis type 2, and schwannomatosis.

Am J Med Genet A 2018 05;176(5):1258-1269

Hereditary Cancer Group, The Institute for Health Science Research Germans Trias i Pujol (IGTP)-PMPPC, Barcelona, Spain.

Organized and hosted by the Children's Tumor Foundation (CTF), the Neurofibromatosis (NF) conference is the premier annual gathering for clinicians and researchers interested in neurofibromatosis type 1 (NF1), neurofibromatosis type 2 (NF2), and schwannomatosis (SWN). The 2016 edition constituted a blend of clinical and basic aspects of NF research that helped in clarifying different advances in the field. The incorporation of next generation sequencing is changing the way genetic diagnostics is performed for NF and related disorders, providing solutions to problems like genetic heterogeneity, overlapping clinical manifestations, or the presence of mosaicism. Read More

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http://dx.doi.org/10.1002/ajmg.a.38675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5918269PMC
May 2018
15 Reads

Patterns of relapse for children with localized intracranial ependymoma.

J Neurooncol 2018 Jun 6;138(2):435-445. Epub 2018 Mar 6.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.

We examined patterns of relapse and prognostic factors in children with intracranial ependymoma. Records of 82 children diagnosed with localized intracranial ependymoma were reviewed. 52% first presented to our institution after relapse. Read More

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http://dx.doi.org/10.1007/s11060-018-2815-7DOI Listing
June 2018
5 Reads

Development of a pre-operative scoring system for predicting risk of post-operative paediatric cerebellar mutism syndrome.

Br J Neurosurg 2018 Feb 12;32(1):18-27. Epub 2018 Feb 12.

b Radiological Sciences, Division of Clinical Neuroscience , University of Nottingham , Nottingham , UK.

Background: Despite previous identification of pre-operative clinical and radiological predictors of post-operative paediatric cerebellar mutism syndrome (CMS), a unifying pre-operative risk stratification model for use during surgical consent is currently lacking. The aim of the project is to develop a simple imaging-based pre-operative risk scoring scheme to stratify patients in terms of post-operative CMS risk.

Methods: Pre-operative radiological features were recorded for a retrospectively assembled cohort of 89 posterior fossa tumour patients from two major UK treatment centers (age 2-23yrs; gender 28 M, 61 F; diagnosis: 38 pilocytic astrocytoma, 32 medulloblastoma, 12 ependymoma, 1 high grade glioma, 1 pilomyxoid astrocytoma, 1 atypical teratoid rhabdoid tumour, 1 hemangioma, 1 neurilemmoma, 2 oligodendroglioma). Read More

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http://dx.doi.org/10.1080/02688697.2018.1431204DOI Listing
February 2018
22 Reads

Unique combination of myxopapillary ependymoma and conus lipoma with subcutaneous extension in an 11-month-old child.

Childs Nerv Syst 2018 Apr 29;34(4):597-599. Epub 2018 Jan 29.

Department of Neurosurgery, Fondazione IRCCS "Istituto Neurologico C. Besta", Via G. Celoria 11, 20133, Milan, Italy.

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http://dx.doi.org/10.1007/s00381-018-3738-5DOI Listing
April 2018
7 Reads

Immunohistochemical comparative analysis of GFAP, MAP - 2, NOGO - A, OLIG - 2 and WT - 1 expression in WHO 2016 classified neuroepithelial tumours and their prognostic value.

Pathol Res Pract 2018 Jan 14;214(1):15-24. Epub 2017 Dec 14.

Department of Neuropathology, Institute of Pathology and Neuropathology, University Hospital of Tuebingen, Eberhard Karls University of Tuebingen and Comprehensive Cancer Center Tuebingen-Stuttgart, Tuebingen, 72076, Germany. Electronic address:

Immunohistochemistry is routinely used in differential diagnosis of tumours of the central nervous system (CNS). The latest 2016 WHO 2016 revision now includes molecular data such as IDH mutation and 1p/19q codeletion thus restructuring glioma classification. Direct comparative information between commonly used immunohistochemical markers for glial tumours GFAP, MAP - 2, NOGO - A, OLIG - 2 and WT - 1 concerning quality and quantity of expression and their relation to the new molecular markers are lacking. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03440338173086
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http://dx.doi.org/10.1016/j.prp.2017.12.009DOI Listing
January 2018
8 Reads

EANO guidelines for the diagnosis and treatment of ependymal tumors.

Neuro Oncol 2018 03;20(4):445-456

Department of Radiation Oncology, Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse, France.

Ependymal tumors are rare CNS tumors and may occur at any age, but their proportion among primary brain tumors is highest in children and young adults. Thus, the level of evidence of diagnostic and therapeutic interventions is higher in the pediatric compared with the adult patient population.The diagnosis and disease staging is performed by craniospinal MRI. Read More

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http://dx.doi.org/10.1093/neuonc/nox166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909649PMC
March 2018
44 Reads

Spinal ependymomas in NF2: a surgical disease?

J Neurooncol 2018 Feb 29;136(3):605-611. Epub 2017 Nov 29.

Department of Neurology, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.

The management of spinal cord ependymomas in Neurofibromatosis Type 2 (NF2) has traditionally been conservative, in contrast to the management of sporadic cases; the assumption being that, in the context of NF2, they did not cause morbidity. With modern management and improved outcome of other NF2 tumours, this assumption, and therefore the lack of role for surgery, has been questioned. To compare the outcome of conservative treatment of spinal ependymomas in NF2 with surgical intervention in selected patients. Read More

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http://dx.doi.org/10.1007/s11060-017-2690-7DOI Listing
February 2018
25 Reads

Extraspinal sacrococcygeal ependymoma masquerading as sacrococcygeal teratoma in the pediatric patient.

Pediatr Surg Int 2018 01 14;34(1):109-112. Epub 2017 Nov 14.

Pediatric Surgery, Medical College of Wisconsin, Milwaukee, WI, USA.

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http://dx.doi.org/10.1007/s00383-017-4214-0DOI Listing
January 2018
10 Reads

Neurological update: gliomas and other primary brain tumours in adults.

J Neurol 2018 Mar 2;265(3):717-727. Epub 2017 Nov 2.

Division of Neuropathology, National Hospital for Neurology and Neurosurgery, University College London NHS Foundation Trust, Queen Square, London, WC1N 3BG, UK.

The emerging understanding of molecular changes in a wide range of brain tumours has led to a significant shift in how these tumours are diagnosed, managed and treated. This article will provide a hands-on overview of the relevant biomarkers and their association with newly defined biological tumour entities. Read More

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http://link.springer.com/10.1007/s00415-017-8652-3
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http://dx.doi.org/10.1007/s00415-017-8652-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834564PMC
March 2018
9 Reads

Novel - Fusion Gene in Pediatric Ependymomas Discovered by Clonal Expansion of Stem Cells in Absence of Exogenous Mitogens.

Cancer Res 2017 11;77(21):5860-5872

UOC Oncologia Pediatrica, Fondazione Policlinico Universitario "A. Gemelli," Rome, Italy.

The basis for molecular and cellular heterogeneity in ependymomas of the central nervous system is not understood. This study suggests a basis for this phenomenon in the selection for mitogen-independent (MI) stem-like cells with impaired proliferation but increased intracranial tumorigenicity. MI ependymoma cell lines created by selection for EGF/FGF2-independent proliferation exhibited constitutive activation of EGFR, AKT, and STAT3 and sensitization to the antiproliferative effects of EGFR tyrosine kinase inhibitors (TKI). Read More

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http://dx.doi.org/10.1158/0008-5472.CAN-17-0790DOI Listing
November 2017
15 Reads

Ependymomas arising outside of the central nervous system: A case series and literature review.

J Clin Neurosci 2018 Jan 18;47:202-207. Epub 2017 Oct 18.

Neuro-Oncology Branch, National Institutes of Health, United States.

Background: Extracranial and extraspinal ependymomas are extremely rare tumors mostly published in the literature as case reports.

Methods: MD Anderson Cancer Center institutional database was screened for patients with extra CNS ependymomas over a 25 year period.

Results: Eight patients with extra CNS ependymoma were identified. Read More

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http://dx.doi.org/10.1016/j.jocn.2017.10.026DOI Listing
January 2018
4 Reads

High-Grade Glioma is not a Feature of Neurofibromatosis Type 2 in the Unirradiated Patient.

Neurosurgery 2018 Aug;83(2):193-196

Department of Manchester Centre for Genomic Medicine, Manchester Academic Health Science Centre, Central Manchester NHS Foundation Trust, Manchester, United Kingdom.

Background: The Manchester criteria for neurofibromatosis type 2 (NF2) include a range of tumors, and gliomas were incorporated in the original description. The gliomas are now widely accepted to be predominantly spinal cord ependymomas.

Objective: To determine whether these gliomas include any cases of malignant glioma (WHO grade III and IV) through a database review. Read More

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http://dx.doi.org/10.1093/neuros/nyx374DOI Listing
August 2018
20 Reads
3.620 Impact Factor

Adjuvant treatments for ependymomas.

J Neurosurg Sci 2018 Feb 22;62(1):71-77. Epub 2017 Sep 22.

Center for Neuro-Oncology, Dana-Farber/Brigham and Women's Cancer Center, Boston, MA, USA -

Ependymomas are rare primary central nervous system tumors occurring in children and young adults. They can be indolent or locally aggressive depending on location, histology, and extent of resection. Treatment involves maximal surgical resection and usually focal radiation therapy, depending on the presence of residual disease and tumor grade. Read More

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http://dx.doi.org/10.23736/S0390-5616.17.04211-4DOI Listing
February 2018
4 Reads

A Review of Visual and Oculomotor Outcomes in Children With Posterior Fossa Tumors.

Semin Pediatr Neurol 2017 05 10;24(2):100-103. Epub 2017 Apr 10.

Department of Ophthalmology, Boston Medical Center, Boston University School of Medicine, Boston, MA; Department of Neurology, Boston Medical Center, Boston University School of Medicine, Boston, MA. Electronic address:

Tumors of the posterior fossa represent the most common solid malignancy of childhood and can affect the visual system in several ways. This article outlines the relevant visual anatomy affected by these tumors and reviews the visual and oculomotor outcomes associated with the following 3 most common tumor types-medulloblastoma, juvenile pilocytic astrocytoma, and ependymoma. The available data suggest that the rate of permanent vision loss is low (5. Read More

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http://dx.doi.org/10.1016/j.spen.2017.04.007DOI Listing
May 2017
18 Reads

Recursive partitioning analysis for disease progression in adult intracranial ependymoma patients.

J Clin Neurosci 2017 Dec 8;46:72-78. Epub 2017 Sep 8.

Department of Neurosurgery, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea. Electronic address:

Intracranial ependymomas are rare tumors in adults. Although recent advancements from demographic, clinical, and biological studies provide new perspectives on this rare tumor, they are not yet widely applied in clinical practice. Currently, most ependymoma patients are treated in the same way: via surgical resection with adjuvant radiation therapy. Read More

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http://dx.doi.org/10.1016/j.jocn.2017.08.056DOI Listing
December 2017
20 Reads

Visual and ocular motor outcomes in children with posterior fossa tumors.

J AAPOS 2017 Oct 1;21(5):375-379. Epub 2017 Sep 1.

Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

Purpose: To describe the clinical characteristics and visual and ocular motor outcomes of a large cohort of pediatric patients treated for tumors of the posterior cranial fossa.

Methods: The medical records of all patients with posterior fossa tumors evaluated by the ophthalmology services at two large tertiary care academic hospitals between 2005 and 2011 were reviewed retrospectively. Data abstracted for each study patient included demographic information, presenting signs and symptoms, pathologic diagnosis, and results of the most recent ophthalmology examination. Read More

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http://dx.doi.org/10.1016/j.jaapos.2017.05.032DOI Listing
October 2017
23 Reads

Recent Advances in the Classification and Treatment of Ependymomas.

Curr Treat Options Oncol 2017 08 10;18(9):55. Epub 2017 Aug 10.

Departments of Neurosurgery and Neurology, Henry Ford Health System, 2799 W Grand Blvd, Detroit, MI, 48202, USA.

Opinion Statement: Ependymomas are a subgroup of ependymal glia-derived neoplasms that affect children as well as adults. Arising within any CNS compartment, symptoms at presentation can range from acute onset due to increased intracranial pressure to insidious myelopathy. The overall survival (OS) outcomes in adult patients across the subgroups is heterogeneous with subependymoma having an excellent prognosis often even in the absence of any treatment, whereas supratentorial ependymomas tend to be higher grade in nature and may have an OS of 5 years despite gross total resection and adjuvant radiation. Read More

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http://dx.doi.org/10.1007/s11864-017-0496-7DOI Listing
August 2017
13 Reads

Immunohistochemical analysis of H3K27me3 demonstrates global reduction in group-A childhood posterior fossa ependymoma and is a powerful predictor of outcome.

Acta Neuropathol 2017 11 21;134(5):705-714. Epub 2017 Jul 21.

Department of Pathology, University of Michigan, Ann Arbor, MI, 48104, USA.

Posterior fossa ependymomas (EPN_PF) in children comprise two morphologically identical, but biologically distinct tumor entities. Group-A (EPN_PFA) tumors have a poor prognosis and require intensive therapy. In contrast, group-B tumors (EPN_PFB) exhibit excellent prognosis and the current consensus opinion recommends future clinical trials to test the possibility of treatment de-escalation in these patients. Read More

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http://dx.doi.org/10.1007/s00401-017-1752-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647236PMC
November 2017
34 Reads

Rethinking childhood ependymoma: a retrospective, multi-center analysis reveals poor long-term overall survival.

J Neurooncol 2017 Oct 21;135(1):201-211. Epub 2017 Jul 21.

Pediatric Neuro-Oncology Program, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Dana-Farber Cancer Institute and Boston Children's Hospital and Harvard Medical School, 450 Brookline Avenue, Boston, MA, 02215, USA.

Ependymoma is the third most common brain tumor in children, but there is a paucity of large studies with more than 10 years of follow-up examining the long-term survival and recurrence patterns of this disease. We conducted a retrospective chart review of 103 pediatric patients with WHO Grades II/III intracranial ependymoma, who were treated at Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Chicago's Ann & Robert H. Lurie Children's Hospital between 1985 and 2008, and an additional 360 ependymoma patients identified from the Surveillance Epidemiology and End Results (SEER) database. Read More

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http://dx.doi.org/10.1007/s11060-017-2568-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658456PMC
October 2017
13 Reads

Malignant central nervous system tumors among adolescents and young adults (15-39 years old) in 14 Southern-Eastern European registries and the US Surveillance, Epidemiology, and End Results program: Mortality and survival patterns.

Cancer 2017 Nov 14;123(22):4458-4471. Epub 2017 Jul 14.

Department of Hygiene, Epidemiology, and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Background: Unique features and worse outcomes have been reported for cancers among adolescents and young adults (AYAs; 15-39 years old). The aim of this study was to explore the mortality and survival patterns of malignant central nervous system (CNS) tumors among AYAs in Southern-Eastern Europe (SEE) in comparison with the US Surveillance, Epidemiology, and End Results (SEER) program.

Methods: Malignant CNS tumors diagnosed in AYAs during the period spanning 1990-2014 were retrieved from 14 population-based cancer registries in the SEE region (n = 11,438). Read More

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http://dx.doi.org/10.1002/cncr.30884DOI Listing
November 2017
43 Reads

Narrative Medicine perspectives on patient identity and integrative care in neuro-oncology.

J Neurooncol 2017 Sep 1;134(2):417-421. Epub 2017 Jul 1.

Markey Cancer Center, University of Kentucky, Lexington, KY, 40536, USA.

Narrative Medicine sessions can encourage patients to rediscover personal identity and meaning by telling or writing their stories. We explored this process to improve care and quality of life for brain cancer patients in an academic neuro-oncology program. Brain cancer and its treatments may threaten a patient's quality of life and sense of self in many ways, including impaired cognitive skills, loss of memory, reduced coordination, and limited capacity for self-expression. Read More

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http://dx.doi.org/10.1007/s11060-017-2542-5DOI Listing
September 2017
6 Reads

Apparent diffusion coefficient in differentiation of pediatric posterior fossa tumors.

Jpn J Radiol 2017 Aug 26;35(8):448-453. Epub 2017 May 26.

Department of Pathology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.

Purpose: To investigate the contribution of preoperative apparent diffusion coefficient (ADC) values in the differential diagnosis of pediatric posterior fossa tumors.

Methods: Forty-two pediatric patients (mean age 7.76 ± 4. Read More

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http://dx.doi.org/10.1007/s11604-017-0652-9DOI Listing
August 2017
52 Reads

p16 Loss and E2F/cell cycle deregulation in infant posterior fossa ependymoma.

Pediatr Blood Cancer 2017 Dec 26;64(12). Epub 2017 May 26.

Department of Pathology, The University of Colorado School of Medicine, Aurora, Colorado.

Background: Posterior fossa (PF) ependymomas (EPNs) in infants less than 1 year of age (iEPN-PF) have a poorer clinical outcome than EPNs in older children. While radiation therapy is the standard of care for the latter, it is withheld in infants to avoid neurotoxicity to immature brain. It is unknown whether the adverse outcome in iEPN-PFs is due to treatment differences or aggressive biology. Read More

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http://dx.doi.org/10.1002/pbc.26656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647247PMC
December 2017
25 Reads

Central nervous system gliomas.

Crit Rev Oncol Hematol 2017 May 22;113:213-234. Epub 2017 Mar 22.

Neurology Medical Center, The Hague, The Netherlands.

Evidence-based practical guidelines on diagnosis, prognosis, and treatment on the most frequent adult brain tumours are delineated. In Europe, 27,000 new cases of malignant glial tumours and 1000 new cases of malignant ependymal tumours are diagnosed every year. The most common glial tumours are glioblastoma multiforme and anaplastic glioma, comprising more than 50% and 10%, respectively, of the total gliomas. Read More

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http://dx.doi.org/10.1016/j.critrevonc.2017.03.021DOI Listing
May 2017
9 Reads

Spinal Schwannoma with Intradural Intramedullary Hemorrhage.

Cureus 2017 Mar 6;9(3):e1082. Epub 2017 Mar 6.

Department of Nephrology, Shifa International Hospital, Islamabad, Pakistan.

Patients with spinal abnormalities infrequently present with intradural intramedullary bleeding. The more common causes include spinal trauma, arteriovenous malformations and saccular aneurysms of spinal arteries. On occasion, spinal cord tumors either primary or metastatic may cause intramedullary bleed with ependymoma of the conus medullaris. Read More

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http://dx.doi.org/10.7759/cureus.1082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383370PMC
March 2017
9 Reads

Telomerase activation in posterior fossa group A ependymomas is associated with dismal prognosis and chromosome 1q gain.

Neuro Oncol 2017 Sep;19(9):1183-1194

Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Austria; Comprehensive Cancer Center, Medical University of Vienna, Austria; Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Austria; Neuromed Campus, Kepler University Hospital, Linz, Austria; Institute of Neurology, Medical University of Vienna, Austria; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Pediatric Oncology, Hematology and Immunology, University Hospital Heidelberg, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany; Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Neuropathology, University Hospital Heidelberg, Germany; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Neurosurgery, Medical University of Vienna, Austria; Department of Radiotherapy, Medical University of Vienna, Austria.

Background: Ependymomas account for up to 10% of childhood CNS tumors and have a high rate of tumor recurrence despite gross total resection. Recently, classification into molecular ependymoma subgroups has been established, but the mechanisms underlying the aggressiveness of certain subtypes remain widely enigmatic. The aim of this study was to dissect the clinical and biological role of telomerase reactivation, a frequent mechanism of cancer cells to evade cellular senescence, in pediatric ependymoma. Read More

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http://dx.doi.org/10.1093/neuonc/nox027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570194PMC
September 2017
23 Reads

Lipomatous/Extensively Vacuolated Ependymoma with Signet-Ring Cell-Like Appearance: Analysis of a Case with Extensive Literature Review.

Case Rep Pathol 2017 14;2017:8617050. Epub 2017 Feb 14.

Department of Neuropathology, National Institute of Neurology & Neurosurgery "Manuel Velasco Suárez", Tlalpan, Mexico City, Mexico.

"Lipomatous" and "extensively vacuolated" are descriptive captions that have been used to portray a curious subset of ependymomas distinctively bearing cells with a large vacuole pushing the nucleus to the periphery and, thus, simulating a signet-ring cell appearance. Here, we would like to report the first ependymoma of this kind in a Latin American institution. A 16-year-old boy experienced cephalea during three months. Read More

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http://dx.doi.org/10.1155/2017/8617050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5329680PMC
February 2017
29 Reads

Glioma Subclassifications and Their Clinical Significance.

Neurotherapeutics 2017 04;14(2):284-297

Department of Neurosurgery, Huntsman Cancer Institute and Clinical Neuroscience Center, University of Utah, Salt Lake City, UT, USA.

The impact of targeted therapies in glioma has been modest. All the therapies that have demonstrated a significant survival benefit for gliomas in Phase III trials, including radiation, chemotherapy (temozolomide and PCV [procarbazine, lomustine, vincristine]), and tumor-treating fields, are based on nonspecific targeting of proliferating cells. Recent advances in the molecular understanding of gliomas suggest some potential reasons for the failure of more targeted therapies in gliomas. Read More

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http://dx.doi.org/10.1007/s13311-017-0519-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398991PMC
April 2017
10 Reads

Intracranial papillary endothelial hyperplasia (Masson's tumour) following gamma knife radiosurgery for temporal lobe epilepsy.

Pract Neurol 2017 Jun 23;17(3):214-217. Epub 2017 Feb 23.

Department of Neurology, Hurstwood Park Neurosciences Centre, Haywards Heath, UK.

We present a rare case of intracranial papillary endothelial hyperplasia, or 'Masson's tumour,' following gamma knife radiosurgery for epilepsy. A 59-year-old woman presented with a 4-month history of escalating headaches and progressive neurological deficit. MR scan of brain showed enlargement of an enhancing right temporal lobe lesion, midline shift and obstructive hydrocephalus. Read More

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http://dx.doi.org/10.1136/practneurol-2016-001573DOI Listing
June 2017
13 Reads