6,327 results match your criteria Ependymoma


Extramedullary Tanycytic Ependymoma in a 12-Year-Old Boy.

J Neurosci Rural Pract 2019 Apr-Jun;10(2):381-383

Department of Pediatrics, Division of Pediatric Neurosurgery, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA.

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http://www.ruralneuropractice.com/text.asp?2019/10/2/381/254
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http://dx.doi.org/10.4103/jnrp.jnrp_263_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454974PMC
April 2019
1 Read

Spinal Cord Ependymoma - Surgical Management and Outcome.

J Neurosci Rural Pract 2019 Apr-Jun;10(2):316-320

Department of Neurosurgery, Beaumont Hospital, Dublin, Ireland.

Background: Ependymoma is a common primary neoplasm of the spinal cord and filum terminale. Patients with spinal ependymoma usually experience gradual symptoms due to slow progression of the tumor; thus, early diagnosis can be challenging to make.

Objective: The objective of this study was to report 5 years' experience in treating spinal intramedullary ependymomas and to illustrate the advantage of aggressive complete resection whenever possible. Read More

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http://dx.doi.org/10.4103/jnrp.jnrp_267_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454966PMC

Clinical analysis of syringomyelia resulting from spinal hemangioblastoma in a single series of 38 consecutive patients.

Clin Neurol Neurosurg 2019 Apr 1;181:58-63. Epub 2019 Apr 1.

Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan province, 450052, PR China; Key laboratory of Neurosurgical Diseases, The First Affiliated Hospital of Zhengzhou University, Jianshe East Road, NO 1, Zhengzhou, Henan Province, 450052, PR China. Electronic address:

Objective: Syringomyelia was predominantly caused by Chiari malformation or intramedullary ependymoma. The goal of this study was to identify factors related to clinical outcomes and spinal hemangioblastoma (SH)-induced syringomyelia formation in a single series of patients.

Patient And Methods: Thirty-eight patients with SH were treated with microsurgery from January 2013 to December 2018. Read More

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http://dx.doi.org/10.1016/j.clineuro.2019.03.025DOI Listing
April 2019
1 Read

Trends in phenotype in the English paediatric Neurofibromatosis Type 2 cohort stratified by genetic severity.

Clin Genet 2019 Apr 16. Epub 2019 Apr 16.

Oxford NF2 Unit, Oxford University Hospitals NHS Foundation Trust.

Childhood onset neurofibromatosis type 2 can be severe and genotype dependent. We present a retrospective phenotypic analysis of all ascertained children in England Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cge.13551
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http://dx.doi.org/10.1111/cge.13551DOI Listing
April 2019
1 Read

5-ALA fluorescence-guided surgery in pediatric brain tumors-a systematic review.

Acta Neurochir (Wien) 2019 Apr 13. Epub 2019 Apr 13.

Department of Neurosurgery, University Hospital Münster, Germany Albert-Schweitzer-Campus 1, Building A1, 48149, Munster, Germany.

Background: 5-Aminolevulinic acid (5-ALA)-guided resection of gliomas in adults enables better differentiation between tumor and normal brain tissue, allowing a higher degree of resection, and improves patient outcomes. In recent years, several reports have emerged regarding the use of 5-ALA in other brain tumor entities, including pediatric brains tumors. Since gross total resection (GTR) of many brain tumors in children is crucial and the role of 5-ALA-guided resection of these tumors is not clear, we sought to perform a comprehensive literature review on this topic. Read More

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http://link.springer.com/10.1007/s00701-019-03898-1
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http://dx.doi.org/10.1007/s00701-019-03898-1DOI Listing
April 2019
2 Reads

Molecular Grouping and Outcomes of Young Children with Newly Diagnosed Ependymoma Treated on the Multi-Institutional SJYC07 Trial.

Neuro Oncol 2019 Apr 12. Epub 2019 Apr 12.

Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.

Background: This report documents the clinical characteristics, molecular grouping and outcome of young children with ependymoma treated prospectively on a clinical trial.

Methods: Fifty-four children (aged ≤ 3 years) with newly diagnosed ependymoma were treated on the SJYC07 trial with maximal safe surgical resection, 4 cycles of systemic chemotherapy, consolidation therapy using focal conformal radiation therapy (RT) (5-mm clinical target volume), and 6 months of oral maintenance chemotherapy. Molecular groups were determined by tumor DNA methylation using Infinium Methylation EPIC BeadChip and profiled on DKFZ/German molecularneuropathology2. Read More

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https://academic.oup.com/neuro-oncology/advance-article/doi/
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http://dx.doi.org/10.1093/neuonc/noz069DOI Listing
April 2019
1 Read

Sudden Unexpected Death in a Child From an Anaplastic Ependymoma.

Am J Forensic Med Pathol 2019 Apr 2. Epub 2019 Apr 2.

N.C. Office of the Chief Medical Examiner, Raleigh, NC.

Primary central nervous system tumors are an extremely rare cause of sudden, unexpected death in children as most patients develop symptoms because of increased intracranial pressure and seek medical attention. Rarely, a forensic pathologist may encounter a primary intracranial neoplasm in a pediatric decedent that was not suspected before death. Herein, we present a case of a supratentorial neuroepithelial tumor found at autopsy in a 3-year-old African American boy without any reported significant medical history. Read More

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http://dx.doi.org/10.1097/PAF.0000000000000480DOI Listing

Cerebellopontine angle ependymoma in a young adult: A case report.

Medicine (Baltimore) 2019 Apr;98(14):e15019

Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, P. R. China.

Rationale: Cerebellopontine angle (CPA) ependymomas are atypical kind of ependymomas that characteristically occur in the pediatric age group. Therefore, finding a case of CPA ependymoma in a young male adult is not a common occurrence.

Patient Concerns: We present a case of a 28-year-old male who was involved in road traffic accident with suspected mild head injury. Read More

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http://dx.doi.org/10.1097/MD.0000000000015019DOI Listing
April 2019
2 Reads

Subpial Cervical Subependymoma: Report of an Unusual Tumor with Review of Literature.

Asian J Neurosurg 2019 Jan-Mar;14(1):329-331

Department of Neurosurgery, SGPGIMS, Lucknow, Uttar Pradesh, India.

Subependymoma is rare benign neoplasm (World Health Organization Grade I) usually found in the 4 ventricle and lateral ventricles. They were first described by Boykin as a separate entity in 1954. Subependymoma constitutes only 1%-2% of spinal ependymal tumors. Read More

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http://dx.doi.org/10.4103/ajns.AJNS_225_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417354PMC
April 2019
1 Read

Aggressive Primary Pediatric Intracranial Malignant Melanoma: Sphinx of the Tissue Diagnosis.

Asian J Neurosurg 2019 Jan-Mar;14(1):275-279

Department of Neurosurgery, Sri Sathya Sai Institute of Higher Medical Sciences, Bengaluru, Karnataka, India.

It is often intriguing to suspect and confirm the diagnosis of primary malignant melanoma (PMM) in the brain without any evidence of neurocutaneous melanosis. We report a 16-year-old male patient with malignant melanoma which intraoperatively was small sized, soft, fleshy, hemorrhagic in appearance resembling hematoma. Interestingly, the histopathology showed prominent papillary architecture with a differential diagnosis of papillary meningioma and ependymoma and perplexed the tissue diagnosis. Read More

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http://dx.doi.org/10.4103/ajns.AJNS_253_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417341PMC
April 2019
2 Reads

Papillary Ependymoma of the Spinal Cord: A Case Report with Summary of Prior Published Cases.

Asian J Neurosurg 2019 Jan-Mar;14(1):223-226

Department of Pathology, IPGME and R, Kolkata, West Bengal, India.

Papillary ependymoma is a rare variant of ependymoma. It has been included in Grade II tumors of updated 2016 WHO classification of central nervous system tumors. Only a handful of cases of spinal papillary ependymomas have been reported so far. Read More

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http://www.asianjns.org/text.asp?2019/14/1/223/231042
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http://dx.doi.org/10.4103/ajns.AJNS_250_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417350PMC
April 2019
5 Reads

A novel imaging flow cytometry method for the detection of histone H4 acetylation in myeloid cells.

Eur J Clin Invest 2019 Mar 31:e13115. Epub 2019 Mar 31.

Newcastle Cancer Centre Pharmacology Group, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK.

Background: The histone deacetylase inhibitor (HDACI) valproic acid has been shown to inhibit the growth of multiple paediatric tumour types and is well tolerated in a childhood cancer setting. The current study was designed to develop a novel imaging flow cytometry method for the detection of histone H4 acetylation in white blood cells obtained from childhood cancer patients treated with valproic acid.

Materials And Methods: HL-60 cells and whole blood samples from healthy volunteers were incubated with valproic acid (0-8 mM) for 0-24 hours, with additional blood samples collected from ependymoma patients receiving valproic acid on the SIOP Ependymoma II clinical trial. Read More

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http://dx.doi.org/10.1111/eci.13115DOI Listing

Review of ependymomas: assessment of consensus in pathological diagnosis and correlations with genetic profiles and outcome.

Brain Tumor Pathol 2019 Mar 30. Epub 2019 Mar 30.

Department of Neuro-Oncology/Neurosurgery, Saitama Medical University International Medical Center, Saitama, Japan.

We focused on histological and immunohistochemical characteristics of ependymoma (EPN) with molecular profiles to develop more reproducible criteria of the diagnosis. Three expert neuropathologists reviewed the pathology of 130 samples from the Japan Pediatric Molecular Neuro-Oncology Group study. Confirmed cases were assessed for histology, surrogate markers, molecular subgrouping, and survival data. Read More

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http://dx.doi.org/10.1007/s10014-019-00338-xDOI Listing
March 2019
2 Reads

EZHIP / CXorf67 mimics K27M mutated oncohistones and functions as an intrinsic inhibitor of PRC2 function in aggressive posterior fossa ependymoma.

Neuro Oncol 2019 Mar 29. Epub 2019 Mar 29.

Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany. (J.-M.H., M.M., S.M.P., K.W.P. and M.K.).

Background: Posterior fossa A (PFA) ependymomas comprise one out of nine molecular groups of ependymoma. PFA tumors are mainly diagnosed in infants and young children, show a poor prognosis and are characterized by a lack of the repressive histone H3 lysine 27 trimethylation (H3K27me3) mark. Recently, we reported CXorf67 overexpression as hallmark of PFA ependymoma and showed that CXorf67 can interact with EZH2 thereby inhibiting polycomb repressive complex 2 (PRC2), but the mechanism of action remained unclear. Read More

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https://academic.oup.com/neuro-oncology/advance-article/doi/
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http://dx.doi.org/10.1093/neuonc/noz058DOI Listing
March 2019
6 Reads

Clinical Relevance of Preoperative MRI in Adolescent Idiopathic Scoliosis: Is Hydromyelia a Predictive Factor of Intraoperative Electrophysiological Monitoring Alterations?

Clin Spine Surg 2019 Mar 25. Epub 2019 Mar 25.

Department of Neurosurgery, IRCCS Policlinico S. Matteo Foundation.

Study Design: This was a prospective cohort study.

Objectives: The main objectives of this study were to evaluate the prevalence and clinical relevance of neuroaxial anomalies in adolescent idiopathic scoliosis (AIS) patients as well as to evaluate different clinical and radiologic variables as potential predictors of the presence of a magnetic resonance imaging (MRI) abnormality.

Summary Of Background Data: The usefulness of preoperative magnetic resonance imaging in AIS is still debated in the literature as well as the clinical relevance of the neuroaxial anomalies detected. Read More

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http://dx.doi.org/10.1097/BSD.0000000000000820DOI Listing
March 2019
6 Reads

Combined Use of Diffusion Tractography and Advanced Intraoperative Imaging for Resection of Cervical Intramedullary Spinal Cord Neoplasms: A Case Series and Technical Note.

Oper Neurosurg (Hagerstown) 2019 Mar 20. Epub 2019 Mar 20.

Department of Neurosurgery, NYU Langone Medical Center, New York, New York.

Background: Intramedullary spinal cord neoplasms (ISCN) pose significant management challenges. Advances in magnetic resonance imaging (MRI) (such as diffusion tensor imaging, DTI) have been utilized to determine the infiltrative nature and resectability of ISCN. However, this has not been applied to intraoperative decision making. Read More

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http://dx.doi.org/10.1093/ons/opz039DOI Listing
March 2019
1 Read

Destructive arthropathy of the shoulder complicating a cervical ependymoma.

Authors:
Zeineb Alaya

Joint Bone Spine 2019 Mar 16. Epub 2019 Mar 16.

Service de médecine interne, hôpital universitaire Mohamed-Tahar-Maamouri de Nabeul, 8000 Nabeul, Tunisia. Electronic address:

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http://dx.doi.org/10.1016/j.jbspin.2019.03.002DOI Listing

Quantitative Analysis of Near-Infrared Indocyanine Green Videoangiography for Predicting Functional Outcomes After Spinal Intramedullary Ependymoma Resection.

Oper Neurosurg (Hagerstown) 2019 Mar 19. Epub 2019 Mar 19.

Department of Neurosurgery, Osaka City University Graduate School of Medicine, Osaka, Japan.

Background: One of the most critical steps in surgery for spinal intramedullary ependymomas is the resection of small feeding arteries from the anterior spinal artery with anatomical preservation of the normal circulation of the ventral spinal cord.

Objective: To quantitatively analyze the microcirculation of the ventral spinal cord by near-infrared indocyanine green videoangiography (ICG-VA) after the spinal intramedullary ependymoma resection.

Methods: This retrospective study included 12 patients (7 male and 5 female; average age 55. Read More

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http://dx.doi.org/10.1093/ons/opz040DOI Listing
March 2019
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Phase I study of gene-mediated cytotoxic immunotherapy with AdV-tk as adjuvant to surgery and radiation for pediatric malignant glioma and recurrent ependymoma.

Neuro Oncol 2019 Mar;21(4):537-546

Division of Hematology/Oncology, Ann & Robert H. Lurie Children's Hospital of Chicago and Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Background: Gene-mediated cytotoxic immunotherapy (GMCI) is a tumor-specific immune stimulatory strategy implemented through local delivery of aglatimagene besadenovec (AdV-tk) followed by anti-herpetic prodrug. GMCI induces T-cell dependent tumor immunity and synergizes with radiotherapy. Clinical trials in adult malignant gliomas demonstrated safety and potential efficacy. Read More

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http://dx.doi.org/10.1093/neuonc/noy202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422437PMC
March 2019
1 Read

Ependymoma of the Spinal Cord in Children: A Retrospective French Study.

World Neurosurg 2019 Mar 12. Epub 2019 Mar 12.

Institut d'Hématologie Oncologie Pédiatrique, Centre Leon Bérard and Hospices Civils de Lyon, Lyon, France.

Background: Ependymoma is the most frequent spinal tumor in adults but it is rather uncommon in children. The aim of the present study was to retrospectively summarize the clinical and therapeutic experience in the treatment of pediatric spinal ependymomas in France.

Methods: In the present retrospective multicenter study, data from patients aged <18 years who had been treated from 2000 to 2010 for spinal ependymomas were collected. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.03.033DOI Listing

Genomic analysis demonstrates that histologically-defined astroblastomas are molecularly heterogeneous and that tumors with MN1 rearrangement exhibit the most favorable prognosis.

Acta Neuropathol Commun 2019 Mar 15;7(1):42. Epub 2019 Mar 15.

Department of Pathology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA.

Astroblastoma (AB) is a rare CNS tumor demonstrating abundant astroblastomatous pseudorosettes. Its molecular features have not been comprehensively studied and its status as a tumor entity is controversial. We analyzed a cohort of 27 histologically-defined ABs using DNA methylation profiling, copy number analysis, FISH and site-directed sequencing. Read More

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http://dx.doi.org/10.1186/s40478-019-0689-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419470PMC
March 2019
1 Read

Spinal melanotic ependymoma: A case report and review of literature.

Pathol Res Pract 2019 Mar 4. Epub 2019 Mar 4.

Department of Neuropathology, Diagnostic & Research Center for Molecular BioMedicine, Institute of Pathology, Medical University of Graz, Austria; Department of Pathology, Medical Faculty, Otto-von-Guericke University Magdeburg, Germany; Department of Pathology, Neuropathology, and Molecular Pathology, Medical University of Innsbruck, Austria; Center for Biomarker Research in Medicine, Graz, Austria; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany. Electronic address:

We describe an adult female patient diagnosed with spinal melanotic ependymoma. She underwent surgery with the aim of gross total resection, but only subtotal resection was possible. Therefore, the patient was re-evaluated 6 weeks following surgery. Read More

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http://dx.doi.org/10.1016/j.prp.2019.03.009DOI Listing

Central nervous system ependymoma: clinical implications of the new molecular classification, treatment guidelines and controversial issues.

Clin Transl Oncol 2019 Mar 13. Epub 2019 Mar 13.

Servicio de Neurocirugía, Hospital Universitario de Burgos, Avda Islas Baleares 3, 09006, Burgos, Spain.

Ependymoma is an uncommon neuroepithelial tumor that may arise anywhere within the neuroaxis, both in children and in adults. It has been classically graded upon histopathological features, yet with limited clinical utility. Recently, DNA methylation profiling has provided a novel classification of ependymoma in nine molecular subgroups. Read More

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http://dx.doi.org/10.1007/s12094-019-02082-2DOI Listing
March 2019
1 Read

The value of high-dose radiotherapy in intracranial ependymoma.

Pediatr Blood Cancer 2019 Jun 13;66(6):e27697. Epub 2019 Mar 13.

Department of Radiation Oncology, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah.

Background: We sought to evaluate the impact of adjuvant radiotherapy dose on overall survival (OS) after surgical resection for localized intracranial ependymoma.

Procedure: The National Cancer Database (NCDB) was queried from 2004 to 2015 for patients of all ages with intracranial WHO grade II to III ependymoma treated with surgery and 4500 to 7000 cGy of adjuvant radiotherapy. Pearson χ test and multivariate logistic regression analyses were used to assess clinicodemographic factors and patterns of care. Read More

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http://dx.doi.org/10.1002/pbc.27697DOI Listing

Characteristics and outcomes in patients with primary intraspinal tumours.

Dan Med J 2019 Mar;66(3)

Introduction: We report a retrospective cohort study aimed at presenting data on incidence, patient char-ac-teristics, tumour type, level of pathology, clinical status before and after surgery and complications in patients with surgically treated primary intraspinal tumours (PIST) in Western Denmark.

Methods: Population-based data were retrieved from hospital files from 1 January 2010 to 31 December 2015.

Results: In total, 78 males and 88 females with PIST were included in the study. Read More

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March 2019
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Newly Diagnosed Metastatic Intracranial Ependymoma in Children: Frequency, Molecular Characteristics, Treatment, and Outcome in the Prospective HIT Series.

Oncologist 2019 Mar 8. Epub 2019 Mar 8.

Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Background: Data on frequency, clinical presentation, and outcome of primary metastatic intracranial ependymoma in children are scarce.

Patients And Methods: Prospective data on patients younger than 21 years with metastatic intracranial ependymoma at first diagnosis, registered from 2001 to 2014 in the HIT-2000 trial and the HIT-2000 Interim Registry, were analyzed.

Results: Of 453 registered patients with intracranial ependymoma and central neuropathology review, initial staging included spinal magnetic resonance imaging in all patients and lumbar cerebrospinal fluid (CSF) analysis in 402 patients. Read More

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http://theoncologist.alphamedpress.org/lookup/doi/10.1634/th
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http://dx.doi.org/10.1634/theoncologist.2018-0489DOI Listing
March 2019
13 Reads

Intradural Extramedullary Spinal Neoplasms: Radiologic-Pathologic Correlation.

Radiographics 2019 Mar-Apr;39(2):468-490

From the Department of Neuroradiology, American Institute for Radiologic Pathology, 1011 Wayne Ave, Suite 320, Silver Spring, MD 20910 (K.K.K., R.Y.S.); Department of Radiology, Mayo Clinic, Rochester, Minn (K.K.K.); Uniformed Services University of the Health Sciences, Bethesda, Md (R.Y.S.); and Department of Radiology, Walter Reed National Military Medical Center, Bethesda, Md (R.Y.S.).

While intradural extramedullary spinal disease varies widely, identification of tumors in this location and their radiologic manifestations greatly facilitates narrowing of the diagnostic considerations. Meningioma and schwannoma are the two most common intradural extramedullary tumors, and both are associated with neurofibromatosis. Meningiomas are most common in the thoracic spine and show a strong female predilection and a clinical manifestation related to compression of the spinal cord or nerve roots. Read More

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http://dx.doi.org/10.1148/rg.2019180200DOI Listing
March 2019
2 Reads

Myxopapillary Ependymoma.

Radiographics 2019 Mar-Apr;39(2):467

American Institute for Radiologic Pathology, Silver Spring, Maryland, and University of Maryland School of Medicine, Baltimore, Maryland ( ).

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http://pubs.rsna.org/doi/10.1148/rg.2019184014
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http://dx.doi.org/10.1148/rg.2019184014DOI Listing
March 2019
5 Reads

[Ependymoma in Sellar Region:Report of One Case].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2019 Feb;41(1):139-142

Department of Radiology,Hainan Hospital of Chinese PLA General Hospital,Sanya,Hainan 572013,China.

Ependymoma arises from the ependymal cells of the ventricles and the ependymal cell nest in the white matter of the extra-ventricles. It may be located inside or outside ventricle and can be anatomically classified into supra- and infratentorial ependymomas. Supratentorial ependymoma can be found both inside and outside ventricle but is rarely seen in the sellar regio. Read More

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http://dx.doi.org/10.3881/j.issn.1000-503X.10397DOI Listing
February 2019
3 Reads

Childhood brain tumors: current management, biological insights, and future directions.

J Neurosurg Pediatr 2019 Mar;23(3):261-273

Brain tumors are the most common solid tumors in children, and, unfortunately, many subtypes continue to have a suboptimal long-term outcome. During the last several years, however, remarkable advances in our understanding of the molecular underpinnings of these tumors have occurred as a result of high-resolution genomic, epigenetic, and transcriptomic profiling, which have provided insights for improved tumor categorization and molecularly directed therapies. While tumors such as medulloblastomas have been historically grouped into standard- and high-risk categories, it is now recognized that these tumors encompass four or more molecular subsets with distinct clinical and molecular characteristics. Read More

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http://dx.doi.org/10.3171/2018.10.PEDS18377DOI Listing
March 2019
9 Reads

Evidence-Based Practice: Temozolomide Beyond Glioblastoma.

Curr Oncol Rep 2019 Mar 5;21(4):30. Epub 2019 Mar 5.

Department of Neurology, University of Michigan, 1500 E. Medical Center Dr., 1914 Taubman Center, Ann Arbor, MI, 48109, USA.

Purpose Of Review: Temozolomide is a first-line treatment for newly diagnosed glioblastoma. In this review, we will examine the use of temozolomide in other contexts for treating gliomas, including recurrent glioblastoma, glioblastoma in the elderly, diffuse low- and high-grade gliomas, non-diffuse gliomas, diffuse intrinsic pontine glioma (DIPG), ependymoma, pilocytic astrocytoma, and pleomorphic xanthoastrocytoma.

Recent Findings: Temozolomide improved survival in older patients with glioblastoma, anaplastic gliomas regardless of 1p/19q deletion status, and progressive ependymomas. Read More

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http://dx.doi.org/10.1007/s11912-019-0783-5DOI Listing
March 2019
2 Reads

A systematic review of outcome in intramedullary ependymoma and astrocytoma.

J Clin Neurosci 2019 May 2;63:168-175. Epub 2019 Mar 2.

RPA Institute of Academic Surgery (IAS), Royal Prince Alfred Hospital, 50 Missenden Rd, Camperdown, NSW 2050, Australia. Electronic address:

The objective was to determine the impact of surgical resection and adjuvant therapies on survival in intramedullary ependymoma and astrocytoma. Secondary goals were to determine predictors of survival in surgical patients including histological grading, age and gender. Searching of Medline, Embase and Clinicaltrials. Read More

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http://dx.doi.org/10.1016/j.jocn.2019.02.001DOI Listing
May 2019
2 Reads

Re-irradiation of locally recurrent pediatric intracranial ependymoma: Experience of the French society of children's cancer.

Radiother Oncol 2019 Mar 20;132:1-7. Epub 2018 Dec 20.

Oncology Radiotherapy Institut de Cancérologie de Lorraine, Vandoeuvre les Nancy, France.

Purpose: This study aimed to evaluate retrospectively the clinical results of re-irradiation for children with a locally recurrent brain ependymoma.

Methods: 33 full-dose re-irradiations were delivered to 31 children with a recurrent brain ependymoma after a standard treatment. Each child was followed up with clinical and MRI examinations. Read More

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http://dx.doi.org/10.1016/j.radonc.2018.11.009DOI Listing
March 2019
2 Reads

Conformal Radiation Therapy for Pediatric Ependymoma, Chemotherapy for Incompletely Resected Ependymoma, and Observation for Completely Resected, Supratentorial Ependymoma.

J Clin Oncol 2019 Apr 27;37(12):974-983. Epub 2019 Feb 27.

22 Hospital for Sick Children, Toronto, Ontario, Canada.

Purpose: The Children's Oncology Group trial ACNS0121 estimated event-free survival (EFS) and overall survival for children with intracranial ependymoma treated with surgery, radiation therapy, and-selectively-with chemotherapy. Treatment was administered according to tumor location, histologic grade, and extent of resection. The impacts of histologic grade, focal copy number gain on chromosome 1q, and DNA methylation profiles were studied for those undergoing surgery and immediate postoperative conformal radiation therapy (CRT). Read More

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http://dx.doi.org/10.1200/JCO.18.01765DOI Listing
April 2019
1 Read
18.428 Impact Factor

Diagnostic errors during intramedullar processes.

Wiad Lek 2019;72(1):129-123

Department of Nervous Diseases with Neurosurgery and Medical Genetics, Ukrainian Medical Stomatological Academy, Poltava, Ukraine.

Objective: Introduction: The article describes a clinical case of a malignant tumor of the brain and spinal cord with metastasis, which remained undetected for many years and was treated as syringomyelia. Long-term exhausting examinations of the brain and spinal cord, dynamic follow-up of medical specialists, and repeated surgical interventions on the spine helped to differentiate this process and make the correct diagnosis. The aim: The objectives of the present paper are to analyze the existing classifications of syringomyelia; to examine its etiology, pathogenesis, diagnostic approaches and treatment tactics; to present a clinical case of a malignant tumor of the brain and spinal cord with metastasis, which was misdiagnosed as syringomyelia. Read More

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January 2019
3 Reads

Methylation array profiling of adult brain tumours: diagnostic outcomes in a large, single centre.

Acta Neuropathol Commun 2019 Feb 20;7(1):24. Epub 2019 Feb 20.

Division of Neuropathology, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, Queen Square, London, WC1N 3BG, UK.

The introduction of the classification of brain tumours based on their DNA methylation profile has significantly changed the diagnostic approach for cases with ambiguous histology, non-informative or contradictory molecular profiles or for entities where methylation profiling provides useful information for patient risk stratification, for example in medulloblastoma and ependymoma. We present our experience that combines a conventional molecular diagnostic approach with the complementary use of a DNA methylation-based classification tool, for adult brain tumours originating from local as well as national referrals. We report the frequency of IDH mutations in a large cohort of nearly 1550 patients, EGFR amplifications in almost 1900 IDH-wildtype glioblastomas, and histone mutations in 70 adult gliomas. Read More

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https://actaneurocomms.biomedcentral.com/articles/10.1186/s4
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http://dx.doi.org/10.1186/s40478-019-0668-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381711PMC
February 2019
3 Reads

Survival and functional outcomes of molecularly defined childhood posterior fossa ependymoma: Cure at a cost.

Cancer 2019 Feb 15. Epub 2019 Feb 15.

Division of Haematology/Oncology, Hospital for Sick Children, Toronto, Ontario, Canada.

Background: Posterior fossa ependymoma (PFE) comprises 2 groups, PF group A (PFA) and PF group B (PFB), with stark differences in outcome. However, to the authors' knowledge, the long-term outcomes of PFA ependymoma have not been described fully. The objective of the current study was to identify predictors of survival and neurocognitive outcome in a large consecutive cohort of subgrouped patients with PFE over 30 years. Read More

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http://dx.doi.org/10.1002/cncr.31995DOI Listing
February 2019
1 Read

Freiburg Neuropathology Case Conference : Posterior Fossa Mass in an Infant.

Clin Neuroradiol 2019 Mar;29(1):177-184

Department of Neuropathology, Medical Centre-University of Freiburg, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1007/s00062-019-00759-3DOI Listing
March 2019
2 Reads

Enabling precision medicine by unravelling disease pathophysiology: quantifying signal transduction pathway activity across cell and tissue types.

Sci Rep 2019 Feb 7;9(1):1603. Epub 2019 Feb 7.

Philips Research, High Tech Campus 11, 5656 AE, Eindhoven, The Netherlands.

Signal transduction pathways are important in physiology and pathophysiology. Targeted drugs aim at modifying pathogenic pathway activity, e.g. Read More

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http://dx.doi.org/10.1038/s41598-018-38179-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367506PMC
February 2019
12 Reads

Fit for Cancer Treatment: a prospective feasibility study of primary care initiated prehabilitation for patients with suspected cancer.

BJGP Open 2018 Dec 17;2(4):bjgpopen18X101608. Epub 2018 Oct 17.

Consultant Surgeon and Head of Specialty School Surgery, Wales Post Graduate Medical and Dental Education Deanery School of Surgery, Cardiff University, Cardiff, UK.

Background: Risk profile assessment and corrective interventions using optimisation of health status and prehabilitation represent an important strategy in the management of patients with a suspected cancer diagnosis.

Aim: To determine the feasibility of pre-treatment optimisation and prehabilitation commenced at index primary care consultation, to improve patients' preparation for treatment by maximising the time available.

Design & Setting: Between January 2015 and May 2016, 195 patients presenting to 12 GP practices were deemed eligible to enter the study, of which 189 (96. Read More

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http://dx.doi.org/10.3399/bjgpopen18X101608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348330PMC
December 2018
3 Reads

Advances in Diagnostic Immunohistochemistry for Primary Tumors of the Central Nervous System.

Authors:
David M Meredith

Adv Anat Pathol 2019 Feb 1. Epub 2019 Feb 1.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

As genomic characterization becomes increasingly necessary for accurate diagnosis of tumors of the central nervous system, identification of rapidly assessible biomarkers is equally important to avoid excessive cost and delay in initiation of therapy. This article reviews novel immunohistochemical markers that may be used to determine mutation status, activation of signaling pathways, druggable targets, and cell lineage in many diverse tumor types. In particular, recently added entities to the 2016 WHO classification of central nervous system tumors will be addressed, including IDH-mutant gliomas, diffuse midline glioma, epithelioid glioblastoma, angiocentric glioma, RELA-rearranged ependymoma, embryonal tumors (medulloblastoma, atypical teratoid/rhabdoid tumor, pineoblastoma, embryonal tumor with multilayered rosettes, and other genetically defined high-grade neuroepithelial tumors), and meningiomas associated with germline alterations. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000225DOI Listing
February 2019
2 Reads

To Treat, or Not to Treat, That is the Question for a 13-Month-Old Girl with Cranial Ependymoma and an Unknown Spinal Mass.

Int J Radiat Oncol Biol Phys 2019 Mar;103(3):542-543

Department of Radiation Oncology, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.ijrobp.2018.09.044DOI Listing

InTAD: chromosome conformation guided analysis of enhancer target genes.

BMC Bioinformatics 2019 Jan 31;20(1):60. Epub 2019 Jan 31.

Department of Medicine, Division of Medical Genetics, University of California San Diego (UCSD), San Diego, USA.

Background: High-throughput technologies for analyzing chromosome conformation at a genome scale have revealed that chromatin is organized in topologically associated domains (TADs). While TADs are relatively stable across cell types, intra-TAD activities are cell type specific. Epigenetic profiling of different tissues and cell-types has identified a large number of non-coding epigenetic regulatory elements ('enhancers') that can be located far away from coding genes. Read More

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https://bmcbioinformatics.biomedcentral.com/articles/10.1186
Publisher Site
http://dx.doi.org/10.1186/s12859-019-2655-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357397PMC
January 2019
8 Reads

Diagnosis and rehabilitation of a pregnant woman with spinal cord disorder due to spinal cord tumor.

Spinal Cord Ser Cases 2019 24;5. Epub 2019 Jan 24.

2Kessler Institute for Rehabilitation, West Orange, NJ USA.

Introduction: Spinal cord tumors are a rare cause of spinal cord disorder (SCD). Early diagnosis can be challenging, especially in patient populations with other potential etiologies for back pain, such as pregnant women.

Case Presentation: A 28-year-old female presented at 8 weeks gestation with thoracic back pain initially diagnosed as gestational low back pain. Read More

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http://dx.doi.org/10.1038/s41394-019-0153-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345917PMC
January 2019
2 Reads

Clinical Characteristics and Prognostic Factors of Treatment in Pediatric Posterior Cranial Fossa Ependymoma.

Pediatr Neurosurg 2019 30;54(2):98-107. Epub 2019 Jan 30.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China,

Objective: The purpose of this study was to explore the clinical features and risk factors of outcomes in pediatric posterior cranial fossa ependymoma. We aim to provide evidence-based recommendations for the improvement of prognoses.

Patients And Methods: The clinical data, treatment modalities, approaches performed, recurrence rates and times, as well as the outcomes of 94 cases were analyzed retrospectively. Read More

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https://www.karger.com/Article/FullText/495809
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http://dx.doi.org/10.1159/000495809DOI Listing
January 2019
6 Reads
0.497 Impact Factor

Influence of pregnancy on glioma patients.

Acta Neurochir (Wien) 2019 Mar 29;161(3):535-543. Epub 2019 Jan 29.

Department of Neurosurgery, Goethe University Hospital, Schleusenweg 2-16, 60528, Frankfurt am Main, Germany.

Background: Data about the influence of pregnancy on progression-free survival and overall survival of glioma patients are sparse and controversial. We aimed at providing further evidence on this relation.

Methods: The course of 18 glioma patients giving birth to 23 children after tumor surgery was reviewed and compared to the course of 18 nulliparous female patients matched for tumor diagnosis including molecular markers, extent of resection, and tumor location. Read More

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http://dx.doi.org/10.1007/s00701-019-03823-6DOI Listing
March 2019
3 Reads
1.788 Impact Factor

Unedited microneurosurgery of a pineal region ependymoma.

Surg Neurol Int 2018 24;9:260. Epub 2018 Dec 24.

International Center for Neurosurgery, Henan Provincial People's Hospital, Zhengzhou, China.

Background: Ependymomas are rarely located in the pineal region. The 2016 WHO classification of tumors of the central nervous system includes five ependymal tumors, the grade I subependymoma and mixopapillary ependymoma, the grade II ependymoma, the grade II-III ependymoma RELA fusion-positive, and the grade III anaplastic ependymoma. However, this grading system has been controversial with respect to its reproducibility and clinical significance and it is estimated that further studies of the molecular characteristics of ependymoma will provide more precise and objective classification. Read More

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http://dx.doi.org/10.4103/sni.sni_355_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322167PMC
December 2018
1 Read

Nivolumab in the Treatment of Recurrent or Refractory Pediatric Brain Tumors: A Single Institutional Experience.

J Pediatr Hematol Oncol 2018 Oct 23. Epub 2018 Oct 23.

Departments of Neurosciences.

Successful use of immune checkpoint inhibitors in a variety of cancers has generated interest in using this approach in pediatric brain tumors. We performed a retrospective review of 10 consecutive children (6 boys, 4 girls; ages, 2 to 17 y), with recurrent or refractory pediatric brain tumors (5 high-grade glioma, 1 low-grade glioma, pineoblastoma, medulloblastoma, ependymoma, and CNS embryonal tumor, NOS) treated at Rady Children's Hospital San Diego from 2015 to 2017 with the immune checkpoint inhibitor nivolumab (3 mg/kg every 2 wk). Eight of 10 patients received prior chemotherapy and 9 radiation therapy. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001339DOI Listing
October 2018
11 Reads