7,125 results match your criteria Ependymoma

Paediatric brain tumours in Singapore: A 15-year epidemiological and outcome study.

J Clin Neurosci 2022 May 18;101:154-161. Epub 2022 May 18.

Division of Neurosurgery, Department of Surgery, National University Health System, Singapore.

Paediatric brain tumours (PBTs) are the most common solid tumours in children. Previous publications reflect variations in incidence rates and frequency of histological types in different global populations. However, there are limited studies on the epidemiology of PBTs in Singapore. Read More

View Article and Full-Text PDF

Diffusely infiltrating glioma with CREBBP-BCORL1 fusion showing overexpression of not only BCORL1 but BCOR: A case report.

Brain Tumor Pathol 2022 May 21. Epub 2022 May 21.

Department of Human Pathology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, Maebashi, Gunma, 371-8511, Japan.

BCORL1 encodes a transcriptional corepressor homolog to BCOR. BCORL1 rearrangements have been previously described as rare events, and among them, CREBBP-BCORL1 has been reported only in 2 cases of ossifying fibromyxoid tumors. Herein, we present the first case of diffusely infiltrating glioma with CREBBP-BCORL1 involving a 17-year-old female patient. Read More

View Article and Full-Text PDF

Phase II study of intravenous etoposide in patients with relapsed ependymoma (CNS 2001 04).

Neurooncol Adv 2022 Jan-Dec;4(1):vdac053. Epub 2022 Apr 13.

Department of Paediatric Oncology, Leeds Children's Hospital, The Leeds Teaching Hospitals NHS Trust, Leeds, UK.

Background: Relapsed ependymoma has a dismal prognosis, and the role of chemotherapy at relapse remains unclear. This study prospectively evaluated the efficacy of intensive intravenous (IV) etoposide in patients less than 21 years of age with relapsed intracranial ependymoma (NCT00278252).

Methods: This was a single-arm, open-label, phase II trial using Gehan's two-stage design. Read More

View Article and Full-Text PDF

Major Features of the 2021 WHO Classification of CNS Tumors.

Neurotherapeutics 2022 May 16. Epub 2022 May 16.

Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

Advances in the understanding of the molecular biology of central nervous system (CNS) tumors prompted a new World Health Organization (WHO) classification scheme in 2021, only 5 years after the prior iteration. The 2016 version was the first to include specific molecular alterations in the diagnoses of a few tumors, but the 2021 system greatly expanded this approach, with over 40 tumor types and subtypes now being defined by their key molecular features. Many tumors have also been reconceptualized into new "supercategories," including adult-type diffuse gliomas, pediatric-type diffuse low- and high-grade gliomas, and circumscribed astrocytic gliomas. Read More

View Article and Full-Text PDF

Recent Molecular and Genetic Findings in Intramedullary Spinal Cord Tumors.

Neurospine 2022 May 16. Epub 2022 May 16.

Department of Neurosurgery, Nagoya University School of Medicine, Nagoya, Japan.

The study of genetic alterations and molecular biology in central nervous system (CNS) tumors has improved the accuracy of estimations of patient prognosis and tumor categorization. Therefore, the updated 2021 World Health Organization (WHO) classification includes various diagnostic genes, molecules, and pathways for diagnosis, as well as histological findings. These findings are expected both to have diagnostic applications and to facilitate new targeted therapies that target tumor-specific genetic changes and molecular biology. Read More

View Article and Full-Text PDF

Extra-Neural Metastases From Primary Intracranial Ependymomas: A Systematic Review.

Front Oncol 2022 27;12:831016. Epub 2022 Apr 27.

Department of Neurosurgery, Trauma Center, Gamma Knife Center, Cannizzaro Hospital, Catania, Italy.

Background: Primary intracranial ependymomas (IE) are rare brain tumors rarely metastasizing outside the central nervous system. We systematically reviewed the literature on extra-neural metastases from primary IEs.

Methods: PubMed, Scopus, Web-of-Science, and Cochrane were searched following the PRISMA guidelines to include studies of extra-neural metastases from primary IEs. Read More

View Article and Full-Text PDF

MRI-based texture analysis for differentiate between pediatric posterior fossa ependymoma type A and B.

Eur J Radiol 2022 Apr 2;152:110288. Epub 2022 Apr 2.

Department of Pathology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, China.

Purpose: The aim of the study was to evaluate the feasibility of texture analysis in differentiating between posterior fossa ependymoma type A (PF-EPN-A) and type B (PF-EPN-B) among children.

Materials And Methods: Our retrospective study included 43 patients (37 PF-EPN-A and 6 PF-EPN-B) who were pathologically diagnosed with ependymomas in the posterior fossa. The texture features were extracted automatically from the volume of interests (VOIs), which were manually delineated on fluid-attenuated inversion recovery (FLAIR), contrast-enhanced T1-weighted (T1C), and diffusion-weighted imaging (DWI) MRI sequences. Read More

View Article and Full-Text PDF

Overview of recent advances in the classification of ependymomas in WHO CNS5 classification: Simplified approach to their integrated diagnosis.

Indian J Pathol Microbiol 2022 May;65(Supplement):S68-S72

Department of Pathology, Neuropathology Division, All India Institute of Medical Sciences, New Delhi, India.

Ependymomas can arise along the entire neuraxis; however, they possess site-specific unique molecular alterations and a methylome pattern which is directly related with the prognostic outcomes. Since 2016, when the updated fourth edition of World Health Organization (WHO) classification of tumors of the central nervous system was published, it has been emphasized to classify ependymomas by anatomic site and molecular signatures associated genetic alterations so that classification of the disease reflects its underlying biology. In continuation, the fifth edition of the WHO classification of CNS tumors introduces major changes, including site-specific molecular profiles as the basis of classifying ependymomas. Read More

View Article and Full-Text PDF

Giant Pediatric Supratentorial Tumor: Clinical Feature and Surgical Strategy.

Front Pediatr 2022 26;10:870951. Epub 2022 Apr 26.

Department of Neurosurgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

Purpose: To analyze the clinical character of giant pediatric supratentorial tumor (GPST) and explore prognostic factors.

Materials And Methods: We analyzed the clinical data comprising of 35 cases of GPST from a single center between January 2015 and December 2020. The tumor volume was measured by 3D slicer software based on preoperative magnetic resonance imaging (MRI). Read More

View Article and Full-Text PDF

Epidemiological characteristics of central nervous system tumors in children: a 5-year review of 3180 cases from Beijing Tiantan Hospital.

Chin Neurosurg J 2022 May 12;8(1):11. Epub 2022 May 12.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Background: To describe the epidemiological characteristics of central nervous system (CNS) tumors in children, based on the neurosurgery department of Beijing Tiantan Hospital.

Methods: From January 2015 to December 2019, 3180 children were histopathologically diagnosed with CNS tumors based on the 2016 World Health Organization (WHO) classification of tumors. Patients were 0 to 15 years old. Read More

View Article and Full-Text PDF

Prognostic Factors and Histopathological Features of Pediatric Intracranial Ependymomas: Nationwide Brain Tumor Registry-based Study of Japan.

Neurol Med Chir (Tokyo) 2022 May 10. Epub 2022 May 10.

Department of Neurological Surgery, School of Medicine, Wakayama Medical University.

To assess the clinicopathological features and prognostic factors of pediatric intracranial ependymomas and to explore the current diagnostic practice, we analyzed clinical data from the Brain Tumor Registry of Japan (BTRJ). Data of fifty children under 18 years of age diagnosed with intracranial ependymoma were extracted from the BTRJ database. Cases were reviewed for overall survival (OS) and progression-free survival (PFS), with attention to gender, preoperative Karnofsky performance status score, location of the tumor, the extent of resection, World Health Organization (WHO) histopathological grading, and adjuvant therapy. Read More

View Article and Full-Text PDF

Multiple spinal intramedullary cavernous angiomas with bleeding episode mimicking an intramedullary tumor.

J Radiol Case Rep 2022 Mar 1;16(3):15-22. Epub 2022 Mar 1.

Anatomical Pathology Department, Faculty of Medicine, Universitas Airlangga, Indonesia.

Intramedullary cavernous angioma is a rare vascular malformation compared to cerebral cavernous malformation. The incidence of cavernous angioma is about 3 - 5% of all central nervous system lesions, 5 - 12% of all spinal vascular lesions, and 1% of all intramedullary lesions in pediatric patients. Although intramedullary cavernous angioma has the same histological picture as cerebral cavernous angioma, the natural history, and surgical approach are different from cerebral cavernous angioma. Read More

View Article and Full-Text PDF

Supratentorial ependymoma, zinc finger translocation-associated fusion positive, with extensive synaptophysin immunoreactivity arising from malignant transformation of clear cell ependymoma: A case report.

Surg Neurol Int 2022 22;13:168. Epub 2022 Apr 22.

Department of Pathology, UT Health San Antonio Long School of Medicine, San Antonio, Texas, United States.

Background: We describe a case of a supratentorial ependymoma, zinc finger translocation-associated () fusion positive with extensive synaptophysin immunoreactivity arising from malignant transformation of an ependymoma with clear cell features in a patient with long-term follow-up.

Case Description: A 55-year-old woman presented with seizures and ataxia 15 years after an initial resection of a clear cell ependymoma, Grade 2. Imaging demonstrated an enhancing right paracentral mass and the patient underwent biopsy and resection. Read More

View Article and Full-Text PDF

Multiple craniospinal tumors in a pediatric patient with neurofibromatosis type 2: a case report.

Childs Nerv Syst 2022 Apr 25. Epub 2022 Apr 25.

Department of Pathology, Chonnam National University Medical School, Chonnam National University Hwasun Hospital, Gwangju, Republic of Korea.

Introduction: Neurofibromatosis type 2 (NF-2) is an inherited disease, linked with abnormalities in the NF-2 gene, which is located on chromosome 22 and involved in merlin production. Many craniospinal tumors are common in individuals with NF-2. We present a case of NF-2 with the rapid symptomatic progression of multiple craniospinal tumors. Read More

View Article and Full-Text PDF

Bilateral Lumbar Radiculopathy Secondary to Myxopapillary Ependymoma: A Case Report.

J Chiropr Med 2021 Sep 6;20(3):170-175. Epub 2022 Apr 6.

Department of Neurosurgery, Cancer Institute of New Jersey, Rutgers University, New Brunswick, New Jersey.

Objective: The purpose of this case report is to describe the presentation of a patient with bilateral lumbar radiculopathy secondary to myxopapillary ependymoma.

Clinical Features: A 45-year-old man presented to a chiropractic office for evaluation and treatment of chronic lower back pain with bilateral lower extremity radiation. The initial onset of pain was related to a lifting injury 6 years prior that never fully resolved. Read More

View Article and Full-Text PDF
September 2021

Multifocal lumbar myxopapillary ependymoma presenting with drop metastasis: a case report and review of the literature.

Spinal Cord Ser Cases 2022 04 22;8(1):43. Epub 2022 Apr 22.

Department of Neurological Surgery, Lenox Hill Hospital, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New York, NY, USA.

Introduction: Spinal myxopapillary ependymomas (SME) are rare WHO grade II neoplasms of the spinal cord. Despite their good prognosis, they have a high propensity for metastasis and recurrence, although the presentation of SME as multifocal is uncommon.

Case Presentation: Here we describe a rare case of a 34-year-old man who presented with painful bilateral radiculopathy with sexual dysfunction and altered sensation with defecation. Read More

View Article and Full-Text PDF

Essential Management of Pediatric Brain Tumors.

Children (Basel) 2022 Apr 2;9(4). Epub 2022 Apr 2.

Pediatric Neurosurgery, Asklepios Children's Hospital, 53757 Sankt Augustin, Germany.

Brain tumors are the most common solid tumors in children and are associated with high mortality. The most common childhood brain tumors are grouped as low-grade gliomas (LGG), high grade gliomas (HGG), ependymomas, and embryonal tumors, according to the World Health Organization (WHO). Advances in molecular genetics have led to a shift from pure histopathological diagnosis to integrated diagnosis. Read More

View Article and Full-Text PDF

It is spatial neglect syndrome, not only attention deficit! A child with spinal ependymoma post-resection misdiagnosed as having ADHD: Case report.

Clin Case Rep 2022 Apr 15;10(4):e05723. Epub 2022 Apr 15.

Child Development Center King Abdullah Abdulaziz University Hospital Princess Nourah Bint Abdulrahman University Riyadh Saudi Arabia.

The neurobehavioral syndrome known as spatial neglect, which could be a result of a brain tumor, is common but difficult to diagnose and manage. This case study describes the evaluation of spatial neglect syndrome psychologically in detail and also builds an initial discussion of the role of the Arabic language, which requires a right-to-left-oriented spatial frame, to understand the severity of the symptoms. We report a case of spatial neglect syndrome after a brain tumor. Read More

View Article and Full-Text PDF

[Microscopic resection of lumbar intraspinal tumor through keyhole approach: A clinical study of 54 cases].

G Z Lin C C Ma C Wu Y Si

Beijing Da Xue Xue Bao Yi Xue Ban 2022 Apr;54(2):315-319

Department of Neurosurgery, Peking University Third Hospital, Beijing 100191, China.

Objective: To explore the feasibility and key technology of microscopic resection of lumbar intraspinal tumor through microchannel keyhole approach.

Methods: The clinical features, imaging characteristics and surgical methods of 54 cases of lumbar intraspinal tumor which were microscopically operated by microchannel from February 2017 to September 2019 were reviewed and analyzed. There were 8 cases of extradural tumor, 3 cases of extra-and intradural tumor and 43 cases of subdural extramedullary tumor (including 3 cases of ventral spinal tumor). Read More

View Article and Full-Text PDF

Resection of Ependymomas Infiltrating the Fourth Ventricular Floor: Anatomosurgical and Stimulation Mapping Techniques.

Oper Neurosurg (Hagerstown) 2022 May;22(5):e189-e197

UCL Queen Square Institute of Neurology, University College London, London, UK.

Background: Despite the importance of complete, gross total resection (GTR) of fourth ventricular ependymomas, significant morbidity and/or subtotal resections are reported, particularly when the ventricular floor is infiltrated. Step-by-step technique descriptions are lacking in the literature.

Objective: To describe monitoring and stimulation mapping techniques and surgical nuances in the challenging subgroup of infiltrating fourth ventricular ependymomas by a highly illustrated, step-by-step description. Read More

View Article and Full-Text PDF

Resection of Giant Remote Recurrence of Ependymoma After 41 Years.

World Neurosurg 2022 Apr 9;163:38. Epub 2022 Apr 9.

Department of Neurosurgery and Brain Repair, University of South Florida, Tampa, Florida, USA.

Ependymomas are rare primary tumors of the brain and spinal cord that arises from the ependymal cell layer. Cranial ependymomas commonly occur in the posterior fossa; however, approximately 30% of all tumors can be found in the supratentorial region. Supratentorial ependymomas have a shorter progression-free and overall survival than their infratentorial counterparts. Read More

View Article and Full-Text PDF

Anatomical Limitation of Posterior Spinal Myelotomy for Intramedullary Hemorrhage Associated with Ependymoma or Cavernous Malformation of the High Cervical Spine.

Neurol Med Chir (Tokyo) 2022 Apr 7. Epub 2022 Apr 7.

Department of Neurosurgery, Osaka Medical and Pharmaceutical University.

Spinal intramedullary tumors such as ependymoma or vascular lesions such as cavernous malformation are often at risk of intramedullary hemorrhage. Surgical procedures involving the high cervical spinal cord are often challenging. This technical note included four patients who presented with acute, subacute, or gradual onset of spinal cord dysfunction associated with intramedullary hemorrhage at the C1 or C1/2 level of the high cervical spine. Read More

View Article and Full-Text PDF

Ependymoma: Evaluation and Management Updates.

Curr Oncol Rep 2022 Apr 6. Epub 2022 Apr 6.

Division of Neuro-Oncology, Department of Neuroscience "Rita Levi Montalcini", University of Turin, Via Cherasco 15, 10126, Turin, Italy.

Purpose Of Review: To review state of art and relevant advances in the molecular genetics and management of ependymomas of children and adults.

Recent Findings: Ependymomas may occur either in the brain or in the spinal cord. Compared with intracranial ependymomas, spinal ependymomas are less frequent and exhibit a better prognosis. Read More

View Article and Full-Text PDF

3D patient-derived tumor models to recapitulate pediatric brain tumors In Vitro.

Transl Oncol 2022 Jun 2;20:101407. Epub 2022 Apr 2.

The Jackson Laboratory for Genomic Medicine, 10 Discovery Drive, Farmington, Connecticut 06030, USA.

Brain tumors are the leading cause of cancer-related deaths in children. Tailored therapies need preclinical brain tumor models representing a wide range of molecular subtypes. Here, we adapted a previously established brain tissue-model to fresh patient tumor cells with the goal of establishing3D in vitro culture conditions for each tumor type. Read More

View Article and Full-Text PDF

Comprehensive profiling of myxopapillary ependymomas identifies a distinct molecular subtype with relapsing disease.

Neuro Oncol 2022 Apr 5. Epub 2022 Apr 5.

Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Background: Myxopapillary ependymoma (MPE) is a heterogeneous disease regarding histopathology and outcome. The underlying molecular biology is poorly understood, and markers that reliably predict the patients' clinical course are unknown.

Methods: We assembled a cohort of 185 tumors classified as MPE based on DNA methylation. Read More

View Article and Full-Text PDF

Long-term Neurologic Outcome After Spinal Ependymoma Resection With Multimodal Intraoperative Electrophysiological Recording: Cohort Study and Review of the Literature.

Neurospine 2022 Mar 31;19(1):118-132. Epub 2022 Mar 31.

Department of Neurosurgery, University of Colorado School of Medicine, Aurora, CO, USA.

Objective: To evaluate how multimodal intraoperative neuromonitoring (IONM) changes during spinal ependymoma (SE) resection correlate with long-term neuro-functional outcomes.

Methods: A retrospective analysis of patients aged 18 years or older who underwent surgical resection for SE over a 10-year period was conducted. IONM changes were defined as sustained transcranial motor evoked potential (TcMEP) and/or somatosensory evoked potential (SSEP) signal decrease of 50% or greater from baseline. Read More

View Article and Full-Text PDF

Intramedullary Spinal Cord Lesions: A Single-Center Experience.

Neurospine 2022 Mar 31;19(1):108-117. Epub 2022 Mar 31.

Department of Neurosurgery, University Hospital of Bordeaux, Bordeaux, France.

Objective: Spinal cord tumors constitute a small part of spinal surgery owing to their rarity. This retrospective study describes their current management.

Methods: Forty-eight patients were treated for an intramedullary tumor between 2014 and 2020 at a single institution. Read More

View Article and Full-Text PDF

ZFTA-fusion in supratentorial ependymomas: low prevalence in South Asians and no correlation with survival.

World Neurosurg 2022 Apr 1. Epub 2022 Apr 1.

Background: - Supratentorial ependymomas (STEs) are an aggressive group of ependymoma, topographically distinct from their posterior fossa and spinal counterparts. ZFTA fusion-positive cases have been reported to account for the majority of STEs, although data on its association with poorer outcomes is inconsistent.

Materials And Methods: - We assessed the prevalence of the ZFTA-fusion by RT PCR and FISH in a cohort of 61 patients (68 samples) with STE. Read More

View Article and Full-Text PDF

"Per protocol" practice patterns for Children's Oncology Group trials within the radiation oncology community.

Pediatr Blood Cancer 2022 Apr 4:e29673. Epub 2022 Apr 4.

Department of Radiation Oncology and Molecular Radiation Sciences, University of Minnesota, Minneapolis, Minnesota, USA.

Little is known about the prevalence of pediatric radiation oncologists treating patients off study according to Children's Oncology Group (COG) trials before data are available regarding toxicity and efficacy of novel radiotherapy regimens. We conducted a 12-question survey of 358 pediatric radiation oncologists to characterize practice patterns regarding ongoing and completed COG protocols off study. With 130 responses (40. Read More

View Article and Full-Text PDF