6,598 results match your criteria Ependymoma


Racial/ethnic Disparities and Survival in Pediatrics with Gliomas Based on the Surveillance Epidemiology and End Results Database in the United States.

World Neurosurg 2020 May 31. Epub 2020 May 31.

Department of Biochemistry and Molecular Biology, College of Basic Medical, Navy Medical University, Shanghai, 200433, P.R.China. Electronic address:

Background: Gliomas are the most common type of primary central nervous system tumor for both children and adults. But the influence of racial/ethnic disparities on the survival of children with gliomas has not been fully evaluated yet.

Methods: Baseline characteristics of patients, including gender, year of diagnosis, surgery, grade, radiation, histology and races, were collected. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.05.224DOI Listing

Microsurgical Resection of an Intramedullary Ependymoma at the Cervicomedullary Junction: A 2-Dimensional Operative Video.

World Neurosurg 2020 May 29. Epub 2020 May 29.

Department of Neurosurgery, MedStar Georgetown University Hospital, Washington, DC, United States.

Ependymomas are the most common adult intramedullary spinal tumors. Although uncommon in the brainstem, ependymomas make up a large proportion of tumors of this location. We present an operative video case report of an intrinsic ependymoma at the cervicomedullary junction. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.05.201DOI Listing

Ependymomas in infancy: underlying genetic alterations, histological features, and clinical outcome.

Childs Nerv Syst 2020 May 30. Epub 2020 May 30.

Department of Neuropathology, DGNN Brain Tumor Reference Center, University of Bonn, Bonn, Germany.

Introduction: Young age is an adverse prognostic factor in children with ependymomas. Treatment of these infants is challenging since beneficial therapeutic options are limited. As ependymomas are considered a biologically heterogeneous group, we aimed to characterize infant ependymomas with regard to their histological and genetic features. Read More

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http://dx.doi.org/10.1007/s00381-020-04655-xDOI Listing

Palliative ventriculoperitoneal shunting in dogs with obstructive hydrocephalus caused by tumors affecting the third ventricle.

J Vet Intern Med 2020 May 30. Epub 2020 May 30.

Servicio de Neurología, Hospital Veterinario VETSIA, Madrid, Spain.

Background: Hypertensive or obstructive hydrocephalus is a common complication in dogs with tumors affecting the third ventricle for which few therapeutic options are available.

Objectives: To describe signalment, neurological status, and pre- and postsurgical findings, complications and survival time in 4 dogs with obstructive hydrocephalus caused by third ventricle tumors that were palliatively treated using ventriculoperitoneal shunting (VPS).

Animals: Four client-owned dogs with obstructive hydrocephalus caused by tumors affecting the third ventricle. Read More

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http://dx.doi.org/10.1111/jvim.15818DOI Listing

Cancer diagnostic profile in children with structural birth defects: An assessment in 15,000 childhood cancer cases.

Cancer 2020 May 29. Epub 2020 May 29.

Department of Medicine, Baylor College of Medicine, Houston, Texas.

Background: Birth defects are established risk factors for childhood cancer. Nonetheless, cancer epidemiology in children with birth defects is not well characterized.

Methods: Using data from population-based registries in 4 US states, this study compared children with cancer but no birth defects (n = 13,111) with children with cancer and 1 or more nonsyndromic birth defects (n = 1616). Read More

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http://dx.doi.org/10.1002/cncr.32982DOI Listing

Poor Prognostic Factors for Surgical Treatment of Spinal Intramedullary Ependymoma (World Health Organization Grade II).

Asian Spine J 2020 May 29. Epub 2020 May 29.

Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan.

Study Design: Single-center retrospective study.

Purpose: We aimed to explore the postoperative prognostic factors for spinal intramedullary ependymoma.

Overview Of Literature: Ependymoma (World Health Organization grade II) is the most frequent intramedullary spinal tumor and is treated by total resection. Read More

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http://dx.doi.org/10.31616/asj.2020.0064DOI Listing

Chondro-Osseous Metaplasia in Ependymoma: A Rare Histopathological Finding.

Case Rep Pathol 2020 5;2020:1528698. Epub 2020 May 5.

Diagnostic Neuroradiology Department, King Faisal Specialist Hospital, Dr. Fakeeh Hospital, Jeddah, Saudi Arabia.

Ependymoma is a circumscribed glioma composed of uniform glial cells with bland nuclei in a fibrillary matrix. It is characterized by the presence of perivascular pseudorosettes. Unusual histopathological findings have rarely been reported in ependymomas, 0. Read More

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http://dx.doi.org/10.1155/2020/1528698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232711PMC

Primary lumbar paraganglioma: clinical, radiological, surgical and histopathological characteristics from a case series of 13 patients.

World Neurosurg 2020 May 23. Epub 2020 May 23.

Department of Neurosurgery, King's College Hospital, London, UK.

Background: Paragangliomas are uncommon neuro-endocrine tumours, rarely occurring in the lumbar spine. Primary lumbar paragangliomas are prominently vascularised, can present variably and pose both diagnostic and surgical challenges. We report on a large case series with long-term follow-up and intra-operative footage to characterise the natural history, diagnostic and operative approach to this rare surgical disease. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.05.144DOI Listing

Freiburg Neuropathology Case Conference : A Hearing-Impaired Patient Presenting with Lower Limb Ataxia and Progressive Personality Changes.

Clin Neuroradiol 2020 May 25. Epub 2020 May 25.

Department of Neuropathology, Medical Centre, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1007/s00062-020-00912-3DOI Listing

Pigmented Ependymoma of the Fourth Ventricle-A Curious Entity: Report of a Rare Case With Review of Literature.

Int J Surg Pathol 2020 May 25:1066896920926700. Epub 2020 May 25.

Manipal Hospital, Bangalore, India.

A 16-year-old boy presented with a tumor located in fourth ventricle, which showed histological features of an ependymoma replete with perivascular pseudorosettes and true ependymal rosettes. Interestingly, many of the tumor cells exhibited abundant cytoplasm stuffed with a grayish brown pigment. Histochemical stains showed the pigment to be acid fast and periodic acid-Schiff positive and negative for Masson-Fontana melanin stain. Read More

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http://dx.doi.org/10.1177/1066896920926700DOI Listing

Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma.

Cell 2020 May 20. Epub 2020 May 20.

The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON M5G 1L7, Canada. Electronic address:

Posterior fossa A (PFA) ependymomas are lethal malignancies of the hindbrain in infants and toddlers. Lacking highly recurrent somatic mutations, PFA ependymomas are proposed to be epigenetically driven tumors for which model systems are lacking. Here we demonstrate that PFA ependymomas are maintained under hypoxia, associated with restricted availability of specific metabolites to diminish histone methylation, and increase histone demethylation and acetylation at histone 3 lysine 27 (H3K27). Read More

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http://dx.doi.org/10.1016/j.cell.2020.04.047DOI Listing
May 2020
32.242 Impact Factor

The Essentials of Molecular Testing in CNS Tumors: What to Order and How to Integrate Results.

Curr Neurol Neurosci Rep 2020 May 22;20(7):23. Epub 2020 May 22.

Department of Pathology, Northwestern University, Simpson-Querrey 6-518, 303 East Superior St., Chicago, IL, 60611, USA.

Purpose Of Review: Molecular testing has become essential for the optimal workup of central nervous system (CNS) tumors. There is a vast array of testing from which to choose, and it can sometimes be challenging to appropriately incorporate findings into an integrated report. This article reviews various molecular tests and provides a concise overview of the most important molecular findings in the most commonly encountered CNS tumors. Read More

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http://dx.doi.org/10.1007/s11910-020-01041-7DOI Listing

Intramedullary spinal cord tumours - a single Centre, 10-year review of clinical and pathological outcomes.

Br J Neurosurg 2020 May 22:1-4. Epub 2020 May 22.

Department of Neurosurgery, Leeds General Infirmary, Leeds, UK.

Intramedullary spinal cord tumours are relatively rare tumours of the central nervous system. Surgical outcomes are affected by many variables, including pre-operative neurological function, tumour histology and extent of resection. Emphasis remains on surgical treatment due to limited adjunctive therapeutic options and poor drug penetration. Read More

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http://dx.doi.org/10.1080/02688697.2020.1765973DOI Listing

Isolated Bilateral Hypoglossal Palsy Complicating a Fourth Ventricle Ependymoma Surgery.

World Neurosurg 2020 May 10. Epub 2020 May 10.

Department of Neurosurgery, APHP, Hôpital de La Pitié-Salpêtrière, Paris, France; Sorbonne Universités, UPMC, Paris, France.

Background: Isolated Bilateral Hypoglossal Palsy is a rare condition that has never been described after surgery in the lower part of the fourth ventricle. In this article, we discuss various possible etiologies and relevant anatomy considerations of the rhomboid fossa.

Case Description: We describe a case of Bilateral Hypoglossal Palsy with tongue ptosis following surgery of an ependymoma in the lower part of the fourth ventricle. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.05.046DOI Listing

Reports of a Conus Cauda Tumor with Holocord Syrinx in an Adolescent Girl.

J Pediatr Neurosci 2020 Jan-Mar;15(1):51-53. Epub 2020 Mar 18.

Department of Pediatrics, K. S. Hegde Medical Academy (KSHEMA), Mangaluru, Karnataka, India.

Introduction: Spinal cord ependymoma seldom presents with holocord syringomyelia in pediatric age-group. Association of ependymoma with a lipoma is also rare. The child presented critically ill with polymicrobial pneumonia, and the neurologic findings were missed until recovery. Read More

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http://dx.doi.org/10.4103/JPN.JPN_96_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227757PMC

Familial Cerebral Cavernous Malformation Syndrome with Concomitant Fourth Ventricular Ependymoma: True Association or Mere Coincidence?

Cancer Genet 2020 May 3;244:36-39. Epub 2020 May 3.

Department of Neurological Surgery, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA. Electronic address:

Familial cerebral cavernous malformation syndromes are most commonly caused by mutations in one of three genes. The overlap of these genetic malformations with other acquired neoplastic lesions and congenital malformations is still under investigation. To the best of our knowledge, the concurrent occurrence of familial cavernous malformations and ependymoma has not been previously reported in the literature. Read More

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http://dx.doi.org/10.1016/j.cancergen.2020.04.075DOI Listing

Margin-free Fractionated Stereotactic Radiotherapy for Pediatric Brain Tumors.

Pract Radiat Oncol 2020 May 16. Epub 2020 May 16.

University of Texas - Southwestern, Department of Radiation Oncology, 2280 Inwood Rd, Dallas, TX 75390. Electronic address:

Background: Conventional radiotherapy (RT) to pediatric brain tumors exposes a large volume of normal brain to unwarranted radiation causing late toxicity. We hypothesized that in well demarcated pediatric tumors lacking microscopic extensions, fractionated stereotactic RT (SRT), without target volume expansions, can reduce high dose normal tissue irradiation without affecting local control.

Methods: Between 2008 and 2017, fifty-two pediatric patients with brain tumors were treated using the CyberKnife (CK) with SRT in 180-200 cGy/fraction. Read More

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http://dx.doi.org/10.1016/j.prro.2020.03.013DOI Listing

Radiology profile as a potential instrument to differentiate between posterior fossa ependymoma (PF-EPN) group A and B.

World Neurosurg 2020 May 16. Epub 2020 May 16.

Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima 734-8551, Japan.

Introduction: Posterior fossa ependymoma (PF-EPN) was categorized into PF-EPN-A and PF-EPN-B subgroups based on the DNA methylation profiling. PF-EPN-A was reported to have poorer prognosis compared to PF-EPN-B. In this study, we particularly evaluated preoperative imaging to distinguish PF-EPN-A from PF-EPN-B. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.05.063DOI Listing

Short-term outcome following surgery for rare brain tumor entities in adults: a Swedish nation-wide registry-based study and comparison with SEER database.

J Neurooncol 2020 May 19. Epub 2020 May 19.

Institute of Neuroscience and Physiology, University of Gothenburg, Sahlgrenska Academy, Gothenburg, Sweden.

Objective: To investigate outcomes after surgery for rare brain tumors using the Swedish Brain Tumor Registry (SBTR).

Methods: This is a nationwide study of patient in the SBTR, validated in the Surveillance, Epidemiology, and End Results (SEER) registries. We included all adults diagnosed 2009-2015 with a rare brain tumor entity (n = 216), defined as ependymoma (EP, n = 64), subependymoma (SUBEP, n = 21), ganglioglioma (GGL, n = 54), pilocytic astrocytoma (PA, n = 56) and primitive neuroectodermal tumor (PNET, n = 21). Read More

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http://dx.doi.org/10.1007/s11060-020-03490-zDOI Listing

Repeated gamma knife radiosurgery enables longer tumor control in cases of highly-recurrent intracranial ependymoma.

J Neurooncol 2020 May 13. Epub 2020 May 13.

Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.

Purpose: Stereotactic radiosurgery (SRS) is a potential re-irradiation treatment for recurrent intracranial ependymoma after prior radiation therapy. The purpose of this study was to examine the efficacy and safety of repeated SRS in the treatment of recurrent intracranial ependymomas.

Methods: This is a retrospective study of consecutive patients with residual or recurrent intracranial ependymomas who were treated with SRS between 1993 and 2018. Read More

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http://dx.doi.org/10.1007/s11060-020-03531-7DOI Listing
May 2020
3.070 Impact Factor

YAP1/TAZ drives ependymoma-like tumour formation in mice.

Nat Commun 2020 May 13;11(1):2380. Epub 2020 May 13.

Kinases and Brain Development Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.

YAP1 gene fusions have been observed in a subset of paediatric ependymomas. Here we show that, ectopic expression of active nuclear YAP1 (nlsYAP5SA) in ventricular zone neural progenitor cells using conditionally-induced NEX/NeuroD6-Cre is sufficient to drive brain tumour formation in mice. Neuronal differentiation is inhibited in the hippocampus. Read More

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http://dx.doi.org/10.1038/s41467-020-16167-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220953PMC

Advances in the molecular classification of pediatric brain tumors: A guide to the galaxy.

J Pathol 2020 May 11. Epub 2020 May 11.

Division of Haematology/Oncology, Department of Pediatrics, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.

Central nervous system (CNS) tumors are the most common solid tumor in pediatrics, accounting for approximately 25% of all childhood cancers, and the second most common pediatric malignancy after leukemia. CNS tumors can be associated with significant morbidity, even those classified as low grade. Mortality from CNS tumors is disproportionately high compared to other childhood malignancies, although surgery, radiation and chemotherapy have improved outcomes in these patients over the last few decades. Read More

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http://dx.doi.org/10.1002/path.5457DOI Listing

Minimally-invasive Parafascicular Surgical (MIPS) Approach for the Management of a Pediatric Third Ventricular Ependymoma: Case Report and Review of Literature.

World Neurosurg 2020 May 5. Epub 2020 May 5.

Department of Clinical Neurosciences (Division of Neurosurgery), Spectrum Health, Grand Rapids, Michigan, USA. Electronic address:

Minimally-invasive parafascicular surgery (MIPS) has evolved into a safe alternative to access deep-seated subcortical and intraventricular pathologies. We present a case of a port-mediated resection of a pediatric third ventricular tumor. The patient is a 7-year-old male who presented with worsening headache, nausea, vomiting, dizziness, unsteady gait, photophobia, and "blind spots" with positional changes. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.04.201DOI Listing

Brain tumors: Medulloblastoma, ATRT, ependymoma.

Pediatr Blood Cancer 2020 May 9:e28395. Epub 2020 May 9.

Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts.

Children with medulloblastoma, atypical teratoid rhabdoid tumor (ATRT), and ependymoma are treated with a multidisciplinary approach including surgery, radiotherapy, and chemotherapy. Lower doses of craniospinal irradiation and tumor bed boost together with chemotherapy are the current standard of care for average-risk medulloblastoma in the Children's Oncology Group (COG). The International Society of Pediatric Oncology (SIOP) is examining the role of hyperfractionated craniospinal irradiation and chemotherapy in high-risk patients. Read More

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http://dx.doi.org/10.1002/pbc.28395DOI Listing

Peripheral circulation miRNA expression of pediatric brain tumors and its relation to tumor miRNA expression levels.

J Neurosurg Pediatr 2020 May 8:1-9. Epub 2020 May 8.

2Department of Pediatrics, University of Connecticut Health Center, Farmington; and.

Objective: Micro RNAs (miRNAs) in peripheral biofluids (e.g., blood, saliva, urine) have been investigated as potential sources of diagnostic and prognostic information for a variety of tumor types, including pediatric brain tumors. Read More

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http://dx.doi.org/10.3171/2020.2.PEDS19715DOI Listing

Proteomics of pediatric ependymomas: a review.

Childs Nerv Syst 2020 May 6. Epub 2020 May 6.

Department of Proteomics, Division of Biotechnology, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.

Ependymomas, affecting both children and adults, are neuroepithelial tumors occurring throughout all compartments of the central nervous system. Pediatric ependymomas arise almost exclusively intracranially and are associated with a poor 10-year overall survival of around 60%. During the last years, the application of multi-omics technologies on the study and understanding of neuro-cancer diseases has become a standard; in this regard, application of these approaches on ependymomas has gained noticeable momentum. Read More

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http://dx.doi.org/10.1007/s00381-020-04627-1DOI Listing

The Role of Predictive Model Based on Quantitative Basic Magnetic Resonance Imaging in Differentiating Medulloblastoma from Ependymoma.

Anticancer Res 2020 May;40(5):2975-2980

School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.

Background/aim: Even though advanced magnetic resonance imaging (MRI) can effectively differentiate between medulloblastoma and ependymoma, it is not readily available throughout the world. This study aimed to investigate the role of simple quantified basic MRI sequences in the differentiation between medulloblastoma and ependymoma in children.

Patients And Methods: The institutional review board approved this prospective study. Read More

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http://dx.doi.org/10.21873/anticanres.14277DOI Listing

Poor academic performance in offspring of survivors with childhood or adolescent central nervous system tumor in Sweden.

Int J Cancer 2020 May 4. Epub 2020 May 4.

Center for Primary Health Care Research, Lund University/Region Skåne, Malmö, Sweden.

The number of children who were born after their parents were diagnosed with central nervous system (CNS) tumor is increasing, but it remains largely unknown regarding the academic performance of these children. We aimed to investigate whether children of survivors with childhood or adolescent CNS tumor were associated with poor academic performance. Children of survivors of CNS tumor were identified by combining the nationwide Swedish Cancer Register and the Multi-Generation Register, and those who have completed compulsory education in Sweden between 1989 and 2015 were included in our study. Read More

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http://dx.doi.org/10.1002/ijc.33034DOI Listing

Analyzing the role of adjuvant or salvage radiotherapy for spinal myxopapillary ependymomas.

J Neurosurg Spine 2020 May 1:1-6. Epub 2020 May 1.

3Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic; and Departments of.

Objective: The authors sought to describe the long-term recurrence patterns, prognostic factors, and effect of adjuvant or salvage radiotherapy (RT) on treatment outcomes for patients with spinal myxopapillary ependymoma (MPE).

Methods: The authors reviewed a tertiary institution IRB-approved database and collected data regarding patient, tumor, and treatment characteristics for all patients treated consecutively from 1974 to 2015 for histologically confirmed spinal MPE. Key outcomes included relapse-free survival (RFS), postrecurrence RFS, failure patterns, and influence of timing of RT on recurrence patterns. Read More

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http://dx.doi.org/10.3171/2020.2.SPINE191534DOI Listing

Recent Advances in Pathology: the 2020 Annual Review Issue of The Journal of Pathology.

J Pathol 2020 Apr;250(5):475-479

RECAMO, Masaryk Memorial Cancer Institute, Brno, Czech Republic.

This year's Annual Review Issue of The Journal of Pathology contains 18 invited reviews on current research areas in pathology. The subject areas reflect the broad range of topics covered by the journal and this year encompass the development and application of software in digital histopathology, implementation of biomarkers in pathology practice; genetics and epigenetics, and stromal influences in disease. The reviews are authored by experts in their field and provide comprehensive updates in the chosen areas, in which there has been considerable recent progress in our understanding of disease. Read More

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http://dx.doi.org/10.1002/path.5425DOI Listing

Gliosarcoma case report and review of the literature.

Pan Afr Med J 2020 3;35:26. Epub 2020 Feb 3.

Department of Pathology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

Gliosarcoma is an unusual subtype of glioblastoma multiforme. Its characteristic features are biphasic configuration, constituting a definite, separate glial and sarcomatous differentiation, on histological evaluation. Herein, we present a rare case of Gliosarcoma that had presented only once in our center in last 13 years. Read More

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http://dx.doi.org/10.11604/pamj.2020.35.26.17577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170742PMC
February 2020

Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma.

Nat Med 2020 May 27;26(5):720-731. Epub 2020 Apr 27.

The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.

Recurrent medulloblastoma and ependymoma are universally lethal, with no approved targeted therapies and few candidates presently under clinical evaluation. Nearly all recurrent medulloblastomas and posterior fossa group A (PFA) ependymomas are located adjacent to and bathed by the cerebrospinal fluid, presenting an opportunity for locoregional therapy, bypassing the blood-brain barrier. We identify three cell-surface targets, EPHA2, HER2 and interleukin 13 receptor α2, expressed on medulloblastomas and ependymomas, but not expressed in the normal developing brain. Read More

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http://dx.doi.org/10.1038/s41591-020-0827-2DOI Listing
May 2020
27.363 Impact Factor

Mobile Myxopapillary Ependymoma with Associated Filum Terminale Cyst.

World Neurosurg 2020 Apr 25;139:337-342. Epub 2020 Apr 25.

Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.

Background: Intradural ependymal cysts are benign, fluid-filled cysts usually situated along the ventral surface of the spinal cord. There are previous reports of 19 intradural cysts in the literature, including one cyst of the filum terminale. Here, we report for the first time the presence of a radiographically occult filum terminale cyst associated with a myxopapillary ependymoma. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.04.095DOI Listing

Ependymoma and pilocytic astrocytoma: Differentiation using radiomics approach based on machine learning.

J Clin Neurosci 2020 Apr 23. Epub 2020 Apr 23.

School of Electrical Engineering, Zhengzhou University, Zhengzhou 450001, China; Industrial Technology Research Institute, Zhengzhou University, Zhengzhou 450001, China; Henan Key Laboratory of Brain Science and Brain-Computer Interface Technology, Zhengzhou University, Zhengzhou 450001, China. Electronic address:

Mandatory accurate and specific diagnosis demands have brought about increased challenges for radiologists in pediatric posterior fossa tumor prediction and prognosis. With the development of high-performance computing and machine learning technologies, radiomics provides increasing opportunities for clinical decision-making. Several studies have applied radiomics as a decision support tool in intracranial tumors differentiation. Read More

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http://dx.doi.org/10.1016/j.jocn.2020.04.080DOI Listing
April 2020
1.318 Impact Factor

Extensive craniospinal disseminated metastasis after the resection of intradural extramedullary ependymoma in the craniocervical junction: a case report and literature review.

Int J Neurosci 2020 Apr 30:1-8. Epub 2020 Apr 30.

Department of Neurosurgery, The Second Affiliated Hospital of Anhui Medical University, Cerebral Vascular Disease Research Centre, Anhui Medical University, Hefei, China.

Intradural extramedullary (IDEM) ependymomas are very rare, and IDEM ependymomas with craniospinal disseminated metastasis are exceptionally rare; only 2 preoperative cases have been confirmed, and postoperative cases have not been reported. We present a case of a 21-year-old female with an IDEM ependymoma of the craniocervical junction who experienced head and neck pain for more than 1 month. Magnetic resonance imaging (MRI) of the cervical spine revealed a large IDEM cystic lesion located in the medulla oblongata and the upper cervical spinal cord. Read More

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http://dx.doi.org/10.1080/00207454.2020.1759585DOI Listing

Primary papillary epithelial tumour of the sella: expanding the spectrum of TTF-1-positive sellar lesions.

Neuropathol Appl Neurobiol 2020 Apr 20. Epub 2020 Apr 20.

Deparment of Histopathology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Aim: To describe four novel primary epithelial tumours of the sella with papillary architecture and Thyroid Transcription Factor 1 (TTF-1) expression.

Methods: Paraffin-embedded tissue from the four cases and recurrence of patient 1 was investigated with haematoxylin-eosin, special histochemical stains, immunohistochemistry with a broad panel of antibodies and next-generation sequencing. The ultrastructure of one tumour was studied in tissue retrieved from paraffin. Read More

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http://dx.doi.org/10.1111/nan.12622DOI Listing

Plasma and cerebrospinal fluid pharmacokinetics of the DNA methyltransferase inhibitor, 5-azacytidine, alone and with inulin, in nonhuman primate models.

Neurooncol Adv 2020 Jan-Dec;2(1):vdaa005. Epub 2020 Jan 1.

Pediatric Neuro-Oncology Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

Background: Epigenetic modifiers are being investigated for a number of CNS malignancies as tumor-associated mutations such as isocitrate dehydrogenase mutations (IDH1/IDH2) and H3K27M mutations, which result in aberrant signaling, are identified. We evaluated the CNS exposure of the DNA methyltransferase inhibitor, 5-azacytidine (5-AZA), in preclinical nonhuman primate (NHP) models to inform its clinical development for CNS tumors.

Methods: 5-AZA and 5-AZA+Inulin pharmacokinetics (PK) were evaluated in NHPs ( = 10) following systemic (intravenous [IV]) and intrathecal (intraventricular [IT-V], intralumbar [IT-L], and cisternal [IT-C]) administration. Read More

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http://dx.doi.org/10.1093/noajnl/vdaa005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146732PMC
January 2020

An application of the Toronto Childhood Cancer Stage Guidelines in three population-based cancer registries: The case of central nervous tumors.

Pediatr Blood Cancer 2020 Jun 17;67(6):e28303. Epub 2020 Apr 17.

Unit of Cancer Epidemiology, Citta' della Salute e della Scienza Hospital and Centre for Cancer Prevention, Turin, Italy.

Background: Cancer stage is a determinant of survival of childhood central nervous system (CNS) cancers and could help the interpretation of survival variability among countries. Consensus guidelines to stage childhood malignancies in population cancer registries ("Toronto Childhood Cancer Stage Guidelines") have been recently proposed with the goal of data comparability. Indeed, stage is not systematically recorded in all registries and, when it is, different classification systems are used. Read More

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http://dx.doi.org/10.1002/pbc.28303DOI Listing

Letter: Neurosurgery and Coronavirus (COVID-19) Epidemic: Doing our Part.

Neurosurgery 2020 Apr 15. Epub 2020 Apr 15.

A.U.O. "Policlinico Umberto I" Neurosurgery Division Sapienza University, Rome Human Neurosciences Department Roma, Italy.

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http://dx.doi.org/10.1093/neuros/nyaa115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184435PMC

Treatment-related calvarial lesions in pediatric brain tumor survivors.

Pediatr Blood Cancer 2020 Jun 14;67(6):e28189. Epub 2020 Apr 14.

Department of Neurosurgery, LeBonheur Children's Hospital, Memphis, Tennessee.

Background: Despite improved survival, many pediatric brain tumor survivors receiving radiation therapy (RT) experience late effects.

Procedure: To study calvarial lesions in this population, we retrospectively reviewed records of patients undergoing neurosurgical evaluation for calvarial bone lesions detected in posttreatment follow-up imaging at St. Jude Children's Research Hospital. Read More

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http://dx.doi.org/10.1002/pbc.28189DOI Listing

Microsurgical techniques for achieving gross total resection of ependymomas of the fourth ventricle.

Acta Chir Belg 2020 Jun 14;120(3):149-166. Epub 2020 Apr 14.

Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.

Ependymomas arising from the ventricular surface present a major challenge to achieving a complete operative extirpation when located in the fourth ventricle given the presence of significant adherence to the floor of the same. Overzealous dissection and removal of a tumor from this zone may precipitate potentially catastrophic neurological deficits attributable to cranial nucleopathies and cranial neuropathies. Consequently, the classic neurosurgical teaching has advised attempted gross total resection, leaving adherent residual in the floor of the fourth ventricle, in order to prevent the development of major cranial nucleopathies and cranial neuropathies. Read More

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http://dx.doi.org/10.1080/00015458.2020.1711593DOI Listing

Anaplastic ependymoma metastases though a ventriculoperitoneal shunt.

Radiol Case Rep 2020 Jun 5;15(6):650-654. Epub 2020 Apr 5.

Department of Radiology, Mayo Clinic, 200 1st St SW, Rochester, MN 55902, USA.

Ependymomas are rare glial tumors that comprise 10% of intracranial pediatric malignancies. Primary central nervous system malignancies can rarely metastasize extracranially. When metastases occur, it usually does so in the setting of surgical manipulation of the central nervous system and can spread through the blood, lymph, or artificial means, for example, a ventriculoperitoneal shunt. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.02.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136589PMC

Predicting postoperative tracheostomy requirement in children undergoing surgery for posterior fossa tumors.

Childs Nerv Syst 2020 Apr 8. Epub 2020 Apr 8.

Department of Neurosurgery, Division of Pediatric Neurosurgery, Baylor College of Medicine, Texas Children's Hospital, 6621 Fannin St, Houston, TX, 77030, USA.

Purpose: Posterior fossa tumor (PFT) resection can be associated with postoperative respiratory failure. We aimed to identify risk factors predicting tracheostomy dependence in children after PFT resection.

Methods: Retrospective chart review of all children undergoing PFT resection from April 2007 to May 2017 at our institution was performed. Read More

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http://dx.doi.org/10.1007/s00381-020-04605-7DOI Listing

Investigation of miRNA and mRNA Co-expression Network in Ependymoma.

Front Bioeng Biotechnol 2020 19;8:177. Epub 2020 Mar 19.

Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.

Ependymoma (EPN) is a rare primary tumor of the central nervous system (CNS) that affects both children and adults. Despite the definition and classification of distinct molecular subgroups, there remains a group of EPNs with a balanced genome, which makes it difficult to predict a prognosis of patients with EPN. The role of miRNA-mRNA network on EPN is still poorly understood. Read More

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http://dx.doi.org/10.3389/fbioe.2020.00177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096354PMC

Leptomeningeal dissemination of low-grade neuroepithelial CNS tumors in adults: a 15-year experience.

Neurooncol Pract 2020 Jan 6;7(1):118-126. Epub 2019 Jul 6.

Department of Neurology, Yale School of Medicine, New Haven, CT, USA.

Background: Leptomeningeal dissemination (LD) in adults is an exceedingly rare complication of low-grade neuroepithelial CNS tumors (LGNs). We aimed to determine relative incidence, clinical presentation, and predictors of outcome.

Methods: We searched the quality control database of the Section of Neuro-Oncology, Yale Cancer Center, for patients with LGN (WHO grade I/II) seen between 2002 and 2017. Read More

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http://dx.doi.org/10.1093/nop/npz020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104875PMC
January 2020

Ten-Segment Intramedullary Ependymoma and Whole Spinal Syringomyelia.

World Neurosurg 2020 Apr 3;139:20-22. Epub 2020 Apr 3.

Department of Neurosurgery, Fudan University Huashan Hospital, Shanghai, China. Electronic address:

Background: Ten-segment intramedullary tumors are rare lesions in adults.

Case Description: In this report, we describe the case of a 30-year-old woman who presented with a 2-year history of right lower limb numbness. Spinal magnetic resonance imaging showed an expansive 10-segment intramedullary lesion and syringomyelia. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.03.149DOI Listing

Unusual imaging appearance of a rare cortical ependymoma mimicking angiocentric glioma.

Neurol Sci 2020 Apr 1. Epub 2020 Apr 1.

Department of Pathology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India.

Cortical ependymomas are uncommon lesions. We report a cortical ependymoma displaying an unusual imaging pattern. The lesion demonstrated a T1 hyperintense rim and limited perilesional edema but lacked contrast enhancement. Read More

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http://dx.doi.org/10.1007/s10072-020-04364-yDOI Listing

Treatment outcome of anaplastic ependymoma under the age of 3 treated by intensity-modulated radiotherapy.

Radiat Oncol J 2020 Mar 25;38(1):26-34. Epub 2020 Mar 25.

Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea.

Purpose: Intensity-modulated radiotherapy (IMRT) allows for more precise treatment, reducing unwanted radiation to nearby structures. We investigated the safety and feasibility of IMRT for anaplastic ependymoma patients below 3 years of age.

Materials And Methods: A total of 9 anaplastic ependymoma patients below 3 years of age, who received IMRT between October 2011 and December 2017 were retrospectively reviewed. Read More

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http://dx.doi.org/10.3857/roj.2020.00073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113147PMC

Differentiation Between Ependymoma and Medulloblastoma in Children with Radiomics Approach.

Acad Radiol 2020 Mar 25. Epub 2020 Mar 25.

School of Physics and Microelectronics, Zhengzhou University, NO.101 Kexue Road, Zhengzhou 450001, PR China. Electronic address:

Rationale And Objectives: Ependymoma (EP) and medulloblastoma (MB) of children are similar in age, location, manifestations and symptoms. Therefore, it is difficult to differentiate them through visual observation in clinical diagnosis. The aim of this study is to investigate the effectiveness of radiomics and machine-learning techniques on multimodal magnetic resonance imaging (MRI) in distinguish EP from MB. Read More

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http://dx.doi.org/10.1016/j.acra.2020.02.012DOI Listing
March 2020
2.077 Impact Factor