6,287 results match your criteria Ependymoma


Methylation array profiling of adult brain tumours: diagnostic outcomes in a large, single centre.

Acta Neuropathol Commun 2019 Feb 20;7(1):24. Epub 2019 Feb 20.

Division of Neuropathology, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, Queen Square, London, WC1N 3BG, UK.

The introduction of the classification of brain tumours based on their DNA methylation profile has significantly changed the diagnostic approach for cases with ambiguous histology, non-informative or contradictory molecular profiles or for entities where methylation profiling provides useful information for patient risk stratification, for example in medulloblastoma and ependymoma. We present our experience that combines a conventional molecular diagnostic approach with the complementary use of a DNA methylation-based classification tool, for adult brain tumours originating from local as well as national referrals. We report the frequency of IDH mutations in a large cohort of nearly 1550 patients, EGFR amplifications in almost 1900 IDH-wildtype glioblastomas, and histone mutations in 70 adult gliomas. Read More

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http://dx.doi.org/10.1186/s40478-019-0668-8DOI Listing
February 2019

Survival and functional outcomes of molecularly defined childhood posterior fossa ependymoma: Cure at a cost.

Cancer 2019 Feb 15. Epub 2019 Feb 15.

Division of Haematology/Oncology, Hospital for Sick Children, Toronto, Ontario, Canada.

Background: Posterior fossa ependymoma (PFE) comprises 2 groups, PF group A (PFA) and PF group B (PFB), with stark differences in outcome. However, to the authors' knowledge, the long-term outcomes of PFA ependymoma have not been described fully. The objective of the current study was to identify predictors of survival and neurocognitive outcome in a large consecutive cohort of subgrouped patients with PFE over 30 years. Read More

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http://dx.doi.org/10.1002/cncr.31995DOI Listing
February 2019
1 Read

Freiburg Neuropathology Case Conference : Posterior Fossa Mass in an Infant.

Clin Neuroradiol 2019 Feb 7. Epub 2019 Feb 7.

Department of Neuropathology, Medical Centre-University of Freiburg, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1007/s00062-019-00759-3DOI Listing
February 2019
1 Read

Enabling precision medicine by unravelling disease pathophysiology: quantifying signal transduction pathway activity across cell and tissue types.

Sci Rep 2019 Feb 7;9(1):1603. Epub 2019 Feb 7.

Philips Research, High Tech Campus 11, 5656 AE, Eindhoven, The Netherlands.

Signal transduction pathways are important in physiology and pathophysiology. Targeted drugs aim at modifying pathogenic pathway activity, e.g. Read More

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http://dx.doi.org/10.1038/s41598-018-38179-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367506PMC
February 2019
2 Reads

Fit for Cancer Treatment: a prospective feasibility study of primary care initiated prehabilitation for patients with suspected cancer.

BJGP Open 2018 Dec 17;2(4):bjgpopen18X101608. Epub 2018 Oct 17.

Consultant Surgeon and Head of Specialty School Surgery, Wales Post Graduate Medical and Dental Education Deanery School of Surgery, Cardiff University, Cardiff, UK.

Background: Risk profile assessment and corrective interventions using optimisation of health status and prehabilitation represent an important strategy in the management of patients with a suspected cancer diagnosis.

Aim: To determine the feasibility of pre-treatment optimisation and prehabilitation commenced at index primary care consultation, to improve patients' preparation for treatment by maximising the time available.

Design & Setting: Between January 2015 and May 2016, 195 patients presenting to 12 GP practices were deemed eligible to enter the study, of which 189 (96. Read More

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http://dx.doi.org/10.3399/bjgpopen18X101608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348330PMC
December 2018
2 Reads

Advances in Diagnostic Immunohistochemistry for Primary Tumors of the Central Nervous System.

Authors:
David M Meredith

Adv Anat Pathol 2019 Feb 1. Epub 2019 Feb 1.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

As genomic characterization becomes increasingly necessary for accurate diagnosis of tumors of the central nervous system, identification of rapidly assessible biomarkers is equally important to avoid excessive cost and delay in initiation of therapy. This article reviews novel immunohistochemical markers that may be used to determine mutation status, activation of signaling pathways, druggable targets, and cell lineage in many diverse tumor types. In particular, recently added entities to the 2016 WHO classification of central nervous system tumors will be addressed, including IDH-mutant gliomas, diffuse midline glioma, epithelioid glioblastoma, angiocentric glioma, RELA-rearranged ependymoma, embryonal tumors (medulloblastoma, atypical teratoid/rhabdoid tumor, pineoblastoma, embryonal tumor with multilayered rosettes, and other genetically defined high-grade neuroepithelial tumors), and meningiomas associated with germline alterations. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000225DOI Listing
February 2019
1 Read

To Treat, or Not to Treat, That is the Question for a 13-Month-Old Girl with Cranial Ependymoma and an Unknown Spinal Mass.

Int J Radiat Oncol Biol Phys 2019 Mar;103(3):542-543

Department of Radiation Oncology, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.ijrobp.2018.09.044DOI Listing

InTAD: chromosome conformation guided analysis of enhancer target genes.

BMC Bioinformatics 2019 Jan 31;20(1):60. Epub 2019 Jan 31.

Department of Medicine, Division of Medical Genetics, University of California San Diego (UCSD), San Diego, USA.

Background: High-throughput technologies for analyzing chromosome conformation at a genome scale have revealed that chromatin is organized in topologically associated domains (TADs). While TADs are relatively stable across cell types, intra-TAD activities are cell type specific. Epigenetic profiling of different tissues and cell-types has identified a large number of non-coding epigenetic regulatory elements ('enhancers') that can be located far away from coding genes. Read More

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https://bmcbioinformatics.biomedcentral.com/articles/10.1186
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http://dx.doi.org/10.1186/s12859-019-2655-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357397PMC
January 2019
1 Read

Diagnosis and rehabilitation of a pregnant woman with spinal cord disorder due to spinal cord tumor.

Spinal Cord Ser Cases 2019 24;5. Epub 2019 Jan 24.

2Kessler Institute for Rehabilitation, West Orange, NJ USA.

Introduction: Spinal cord tumors are a rare cause of spinal cord disorder (SCD). Early diagnosis can be challenging, especially in patient populations with other potential etiologies for back pain, such as pregnant women.

Case Presentation: A 28-year-old female presented at 8 weeks gestation with thoracic back pain initially diagnosed as gestational low back pain. Read More

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http://dx.doi.org/10.1038/s41394-019-0153-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345917PMC
January 2019
1 Read

Clinical Characteristics and Prognostic Factors of Treatment in Pediatric Posterior Cranial Fossa Ependymoma.

Pediatr Neurosurg 2019 Jan 30:1-10. Epub 2019 Jan 30.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing,

Objective: The purpose of this study was to explore the clinical features and risk factors of outcomes in pediatric posterior cranial fossa ependymoma. We aim to provide evidence-based recommendations for the improvement of prognoses.

Patients And Methods: The clinical data, treatment modalities, approaches performed, recurrence rates and times, as well as the outcomes of 94 cases were analyzed retrospectively. Read More

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https://www.karger.com/Article/FullText/495809
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http://dx.doi.org/10.1159/000495809DOI Listing
January 2019
2 Reads
0.497 Impact Factor

Influence of pregnancy on glioma patients.

Acta Neurochir (Wien) 2019 Jan 29. Epub 2019 Jan 29.

Department of Neurosurgery, Goethe University Hospital, Schleusenweg 2-16, 60528, Frankfurt am Main, Germany.

Background: Data about the influence of pregnancy on progression-free survival and overall survival of glioma patients are sparse and controversial. We aimed at providing further evidence on this relation.

Methods: The course of 18 glioma patients giving birth to 23 children after tumor surgery was reviewed and compared to the course of 18 nulliparous female patients matched for tumor diagnosis including molecular markers, extent of resection, and tumor location. Read More

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http://dx.doi.org/10.1007/s00701-019-03823-6DOI Listing
January 2019
1 Read
1.788 Impact Factor

Unedited microneurosurgery of a pineal region ependymoma.

Surg Neurol Int 2018 24;9:260. Epub 2018 Dec 24.

International Center for Neurosurgery, Henan Provincial People's Hospital, Zhengzhou, China.

Background: Ependymomas are rarely located in the pineal region. The 2016 WHO classification of tumors of the central nervous system includes five ependymal tumors, the grade I subependymoma and mixopapillary ependymoma, the grade II ependymoma, the grade II-III ependymoma RELA fusion-positive, and the grade III anaplastic ependymoma. However, this grading system has been controversial with respect to its reproducibility and clinical significance and it is estimated that further studies of the molecular characteristics of ependymoma will provide more precise and objective classification. Read More

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http://dx.doi.org/10.4103/sni.sni_355_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322167PMC
December 2018

Nivolumab in the Treatment of Recurrent or Refractory Pediatric Brain Tumors: A Single Institutional Experience.

J Pediatr Hematol Oncol 2018 Oct 23. Epub 2018 Oct 23.

Departments of Neurosciences.

Successful use of immune checkpoint inhibitors in a variety of cancers has generated interest in using this approach in pediatric brain tumors. We performed a retrospective review of 10 consecutive children (6 boys, 4 girls; ages, 2 to 17 y), with recurrent or refractory pediatric brain tumors (5 high-grade glioma, 1 low-grade glioma, pineoblastoma, medulloblastoma, ependymoma, and CNS embryonal tumor, NOS) treated at Rady Children's Hospital San Diego from 2015 to 2017 with the immune checkpoint inhibitor nivolumab (3 mg/kg every 2 wk). Eight of 10 patients received prior chemotherapy and 9 radiation therapy. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001339DOI Listing
October 2018
3 Reads

MicroRNA expression in pediatric intracranial ependymomas and their potential value for tumor grading.

Oncol Lett 2019 Jan 12;17(1):1379-1383. Epub 2018 Nov 12.

Department of Pathology and Molecular Medicine, Second Faculty of Medicine, Charles University and University Hospital Motol, 150 06 Prague 5, Czech Republic.

Intracranial ependymoma represents one of the most common pediatric central nervous system malignancies, and exhibits a wide range of clinical behavior from relatively indolent lesions to highly malignant anaplastic ependymomas. Due to the heterogeneous nature of this disease there is lack of prognostic markers, which would reliably predict the outcome of patients. MicroRNAs (miRNAs) have emerged as important molecules in cancer biology during past decade; however, very little is known about their role in ependymomas. Read More

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http://dx.doi.org/10.3892/ol.2018.9685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313077PMC
January 2019

Telovelar Approach to Pediatric Fourth Ventricle Tumors: Feasibility and Outcome.

Turk Neurosurg 2018 Sep 25. Epub 2018 Sep 25.

Faculty of Medicine,Cairo University.

Aim: Traditionally, the fourth ventricle is approached via the cerebellar vermis. The approach via the telovelar fold (telovelar approach) has been designed to avoid neural tissue damage. Here we describe our institution's experience with the telovelar approach as well as factors governing radicality and outcome. Read More

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http://dx.doi.org/10.5137/1019-5149.JTN.24078-18.3DOI Listing
September 2018
1 Read
0.529 Impact Factor

Identification of Driver Genes and Key Pathways of Ependymoma.

Turk Neurosurg 2018 Jun 30. Epub 2018 Jun 30.

The First Hospital of Jilin University.

Aim: Objective: To identify ependymoma (EPN) driver genes and key pathways, and also to illuminate the connection between prognosis of EPN patients and expression levels of driver genes.

Material And Methods: Methods: The gene expression profiles of GSE50161, GSE66354, GSE74195, and GSE86574 were analyzed to figure out the differentially expressed genes (DEGs) between tissue of EPN and normal brain samples. To harvest the enrichment functions, pathways and hub genes, the Gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, and protein-protein interaction (PPI) network analysis were made. Read More

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http://dx.doi.org/10.5137/1019-5149.JTN.21876-17.5DOI Listing

[The application of ultrasonic bone curette in laminoplasty of spinal canal after resection of intraspinal tumors].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2019 Jan;33(1):61-65

Department of Spine Surgery, Luoyang Orthopedic Hospital of Henan Province (Henan Orthopedic Hospital), Henan Luoyang, 471002, P.R.China.

Objective: To explore the practicability and safety of ultrasonic bone curette in the laminoplasty of spinal canal after resection of intraspinal tumors.

Methods: The clinical data of 17 patients with thoracolumbar intraspinal tumors treated with ultrasonic bone curette after resection of intraspinal tumors between December 2015 and April 2017 were retrospectively analyzed. All patients were male, aged 42-73 years with an average of 57. Read More

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http://dx.doi.org/10.7507/1002-1892.201807086DOI Listing
January 2019
1 Read

National Patterns of Care in the Management of World Health Organization Grade II and III Spinal Ependymomas.

World Neurosurg 2019 Jan 11. Epub 2019 Jan 11.

Department of Radiation Oncology, MD Anderson Cancer Center, University of Texas, Houston, Texas, USA.

Background: Spinal ependymomas are rare, with an incidence of 1 per 100,000. Given the paucity of data for higher grade II and III disease, the management and patterns of care require further investigation.

Methods: Our study of 1345 patients with higher-grade spinal ependymoma used χ tests and simple and multivariable logistic regression models to assess demographic and clinical factors associated with therapy. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.12.159DOI Listing
January 2019
1 Read

A novel type of C11orf95-LOC-RELA fusion in a grade II supratentorial ependymoma: report of a case with literature review.

Childs Nerv Syst 2019 Jan 10. Epub 2019 Jan 10.

Departments of Pediatrics, Ribeirão Preto Medical of School, University of São Paulo, Ribeirão Preto, SP, Brazil.

Background: Ependymoma (EPN) is the third most common central nervous system tumor in childhood. Recent advances in the molecular classification of EPN revealed a supratentorial (ST) ependymoma subgroup characterized by C11orf95-RELA fusion.

Case Report: We describe a novel RELA-fusion composed by a chimeric transcript C11orf95-LOC-RELA in a supratentorial WHO grade II EPN occurring in a 4-year-old child. Read More

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http://dx.doi.org/10.1007/s00381-018-04028-5DOI Listing
January 2019
1 Read

Trajectories of psychosocial and cognitive functioning in pediatric patients with brain tumors treated with radiation therapy.

Neuro Oncol 2019 Jan 8. Epub 2019 Jan 8.

Department of Radiation Oncology, St. Jude Children's Research Hospital.

Background: Pediatric patients with brain tumors who are treated with radiation therapy (RT) are at risk for neurocognitive and psychosocial late effects. Research to date has primarily examined these outcomes at a group level and in isolation. Advanced statistical techniques allow for person-centered analyses, as well as examination of relationships between domain-specific trajectories. Read More

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https://academic.oup.com/neuro-oncology/advance-article/doi/
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http://dx.doi.org/10.1093/neuonc/noz010DOI Listing
January 2019
5 Reads

Management of Ependymoma in Children, Adolescents and Young Adults.

Authors:
N Thorp L Gandola

Clin Oncol (R Coll Radiol) 2019 Mar 4;31(3):162-170. Epub 2019 Jan 4.

Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Paediatric ependymomas are rare, malignant tumours arising throughout the central nervous system, but most frequently (in children) the posterior fossa. The standard of care for localised disease is gross total resection and focal radiotherapy, resulting in overall survival rates of up to 85%. Despite improvements in survival, treatment remains challenging, with persistently high rates of (rarely curable) relapse alongside risks of significant tumour and treatment-related toxicity. Read More

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http://dx.doi.org/10.1016/j.clon.2018.12.001DOI Listing

Cancer risk in children and young adults born preterm: A systematic review and meta-analysis.

PLoS One 2019 4;14(1):e0210366. Epub 2019 Jan 4.

Department of Pediatrics, Sainte-Justine University Hospital and Research Center, University of Montreal, Montreal, Quebec, Canada.

Introduction: Risk of developing a malignancy when born premature is unknown. We hypothesised that risk of certain cancers might be increased in youth born preterm versus term. We therefore performed a systematic review and meta-analysis to evaluate the incidence of malignancy in the context of preterm birth, according to various cancer types. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210366PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319724PMC
January 2019
8 Reads

Predicting Survival of Patients with Spinal Ependymoma Using Machine Learning Algorithms with the SEER Database.

World Neurosurg 2018 Dec 28. Epub 2018 Dec 28.

Department of Neurosurgery, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Republic of Korea.

Objective: This study was conducted to understand the clinical and demographic factors influencing the overall survival (OS) of patients with spinal ependymoma and to predict the OS with machine learning (ML) algorithms.

Methods: We compiled spinal ependymoma cases diagnosed between 1973 and 2014 from the Surveillance, Epidemiology, and End Results (SEER) registry. To identify the factors influencing survival, statistical analyses were performed using the Kaplan-Meier method and Cox proportional hazards regression model. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.12.091DOI Listing
December 2018

Individualized treatment for a case of recurrent ovarian ependymoma.

Onco Targets Ther 2019 20;12:113-117. Epub 2018 Dec 20.

Department of Obstetrics and Gynecology, LuHe hospital, Capital Medical University, Beijing, China.

Ovarian anaplastic ependymoma is a rare gynecologic malignancy. Owing to its rarity, treatment is challenging. Unilateral ovarian ependymoma was found during laparoscopy in a 19-year-old woman. Read More

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https://www.dovepress.com/individualized-treatment-for-a-cas
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http://dx.doi.org/10.2147/OTT.S180309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304260PMC
December 2018
10 Reads
1.342 Impact Factor

Microsurgical Resection of Low-Grade Spinal Cord Astrocytoma: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2018 Dec 19. Epub 2018 Dec 19.

Semmes Murphey Neurologic & Spine Institute, Memphis, Tennessee.

This video demonstrates microsurgical resection of low-grade (Grade I) thoracic spinal cord astrocytoma. Astrocytomas are the most common pediatric intramedullary tumors and occur secondary to ependymomas in adults.1,2 The treatment goal should be radical gross total resection while preserving neurological function with intraoperative neuromonitoring. Read More

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https://academic.oup.com/ons/advance-article/doi/10.1093/ons
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http://dx.doi.org/10.1093/ons/opy386DOI Listing
December 2018
5 Reads

Limitations of current models for testing the clinical potential of epigenetic inhibitors for treatment of pediatric ependymoma.

Oncotarget 2018 Nov 23;9(92):36530-36541. Epub 2018 Nov 23.

Children's Brain Tumour Research Centre, School of Medicine, University of Nottingham, Nottingham, UK.

Background: Epigenetic modifications have been shown to play an important role in the classification and pathogenesis of the pediatric brain tumor ependymoma, suggesting they are a potential therapeutic target.

Results: Agents targeting epigenetic modifications inhibited the growth and induced the death of ependymoma cells with variable efficiency. However, this was often not at clinically achievable doses. Read More

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http://www.oncotarget.com/fulltext/26370
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http://dx.doi.org/10.18632/oncotarget.26370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284855PMC
November 2018
1 Read

Neurocognitive, academic and functional outcomes in survivors of infant ependymoma (UKCCSG CNS 9204).

Childs Nerv Syst 2019 Mar 15;35(3):411-420. Epub 2018 Dec 15.

Children's Brain Tumour Research Centre, Academic Division of Child Health, Queen's Medical Centre, University of Nottingham, Nottingham, NG7 2RD, UK.

Purpose: This is the first UK multi-centre case-controlled study with follow-up in excess of 10 years to report the neurocognitive, academic and psychological outcomes of individuals diagnosed with a brain tumour in early childhood. Children enrolled into the UKCCSG CNS 9204 trial, diagnosed with intracranial ependymoma when aged ≤ 36 months old, who received a primary chemotherapy strategy to defer or avoid radiotherapy, were recruited.

Methods: Outcomes of those who relapsed and subsequently received radiotherapy (n = 13) were compared to those enrolled who did not relapse (n = 16), age-matched controls-diagnosed with solid non-central nervous system (SN-CNS; n = 15) tumours or low-grade posterior fossa pilocytic astrocytoma (PFPA; n = 15), and normative data. Read More

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http://link.springer.com/10.1007/s00381-018-4015-3
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http://dx.doi.org/10.1007/s00381-018-4015-3DOI Listing
March 2019
11 Reads
1.163 Impact Factor

Tanycytic ependymoma of filum terminale: Clinical characteristics and surgical outcomes.

Oncol Lett 2018 Dec 1;16(6):6910-6917. Epub 2018 Oct 1.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, P.R. China.

Tanycytic ependymoma (TE), a rare subtype of ependymoma, was classified as grade II ependymoma by the World Health Organization in 2000 and 2007. Preoperative diagnosis of TE is challenging due to its similarities to schwannoma and astrocytoma; therefore, differentiation is required. The present study investigated the clinical, imaging and pathological characteristics of TE in the filum terminale. Read More

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http://www.spandidos-publications.com/10.3892/ol.2018.9531
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http://dx.doi.org/10.3892/ol.2018.9531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256739PMC
December 2018
7 Reads

Microneurosurgical Removal of a Cervical Intramedullary Tumor Via Hemilaminoplasty: 3-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2018 Dec 12. Epub 2018 Dec 12.

Department of Neurosurgery, Yeditepe University School of Medicine, Istanbul, Turkey.

Intramedullary tumors of the spinal cord are rare and account for 2% to 8.5% of all central nervous system tumors. In adults, ependymomas are the most common intramedullary tumors. Read More

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http://dx.doi.org/10.1093/ons/opy297DOI Listing
December 2018
1 Read

Surgical outcome in cortical ependymoma: A single centre experience of 18 cases.

J Clin Neurosci 2019 Feb 24;60:49-57. Epub 2018 Oct 24.

Pathology, SGPGIMS, India.

Cortical ependymomas (CE) are rare subset of supratentorial ependymoma which are located in the peripheral cortical rim without any connection to the ventricular lining. With limited cases previously reported, current knowledge on diagnosis and management of tumors is lacking. We present the largest single center experience on CE reported so far and highlight their clinico-radiological aspects, histopathological features as well the results of their surgical excision. Read More

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http://dx.doi.org/10.1016/j.jocn.2018.10.036DOI Listing
February 2019
2 Reads
1.318 Impact Factor

Identifying the deficiencies of current diagnostic criteria for neurofibromatosis 2 using databases of 2777 individuals with molecular testing.

Genet Med 2018 Dec 7. Epub 2018 Dec 7.

Department of Genomic Medicine, St Mary's Hospital, Manchester Academic Health Sciences Centre (MAHSC), Division of Evolution and Genomic Science, University of Manchester, Manchester, UK.

Purpose: We have evaluated deficiencies in existing diagnostic criteria for neurofibromatosis 2 (NF2).

Methods: Two large databases of individuals fulfilling NF2 criteria (n = 1361) and those tested for NF2 variants with criteria short of diagnosis (n = 1416) were interrogated. We assessed the proportions meeting each diagnostic criterion with constitutional or mosaic NF2 variants and the positive predictive value (PPV) with regard to definite diagnosis. Read More

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http://dx.doi.org/10.1038/s41436-018-0384-yDOI Listing
December 2018
4 Reads
7.329 Impact Factor

Radiosurgery or hypofractionated stereotactic radiotherapy after craniospinal irradiation in children and adults with medulloblastoma and ependymoma.

Childs Nerv Syst 2019 Feb 4;35(2):267-275. Epub 2018 Dec 4.

Department of Radiotherapy, The Maria Sklodowska-Curie Institute - Oncology Center, Gliwice Branch, Ul. Wybrzeże AK 15, 44-101, Gliwice, Poland.

Purpose: To assess the results and tolerance of radiosurgery/hypofractionated stereotactic radiotherapy performed after craniospinal irradiation for recurrent tumor.

Methods: Fourteen patients aged 3-46 years, diagnosed with medulloblastoma (10), anaplastic ependymoma (3), and primitive neuroectodermal tumor (1). All patients had craniospinal irradiation (CSI) with the total dose of 30. Read More

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http://dx.doi.org/10.1007/s00381-018-4010-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351705PMC
February 2019
2 Reads

Significance of molecular classification of ependymomas: C11orf95-RELA fusion-negative supratentorial ependymomas are a heterogeneous group of tumors.

Acta Neuropathol Commun 2018 Dec 4;6(1):134. Epub 2018 Dec 4.

Division of Brain Tumor Translational Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

Extensive molecular analyses of ependymal tumors have revealed that supratentorial and posterior fossa ependymomas have distinct molecular profiles and are likely to be different diseases. The presence of C11orf95-RELA fusion genes in a subset of supratentorial ependymomas (ST-EPN) indicated the existence of molecular subgroups. However, the pathogenesis of RELA fusion-negative ependymomas remains elusive. Read More

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https://actaneurocomms.biomedcentral.com/articles/10.1186/s4
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http://dx.doi.org/10.1186/s40478-018-0630-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278135PMC
December 2018
3 Reads

Neuroendoscopic Aspiration of Blood Clots in the Cerebral Aqueduct and Third Ventricle During Posterior Fossa Surgery in the Prone Position.

Oper Neurosurg (Hagerstown) 2018 Nov 28. Epub 2018 Nov 28.

Department of Neurosciences, Neurosurgery Unit, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy.

Background: During surgery in the posterior fossa in the prone position, blood can sometimes fill the surgical field, due both to the less efficient venous drainage compared to the sitting position and the horizontally positioned surgical field itself. In some cases, blood clots can wedge into the cerebral aqueduct and the third ventricle, and potentially cause acute hydrocephalus during the postoperative course.

Objective: To illustrate a technique that can be used in these cases: the use of a flexible scope introduced through the opened roof of the fourth ventricle with a freehand technique allows the navigation of the fourth ventricle, the cerebral aqueduct, and the third ventricle in order to explore the cerebrospinal fluid pathways and eventually aspirate blood clots and surgical debris. Read More

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http://dx.doi.org/10.1093/ons/opy324DOI Listing
November 2018

Lumbar epidural analgesia for labor in a parturient with a history of surgery for lumbar intradural ependymoma: Literature review and case presentation.

Surg Neurol Int 2018 23;9:211. Epub 2018 Oct 23.

Department of Anesthesiology, Advocate Illinois Masonic Medical Center, Chicago, Illinois, USA.

Background: Ependymomas represent 50-60% of all brain and central nervous system tumors. Previous lumbar spine surgery for resection of an ependymoma should not be considered a relative contraindication for the administration of epidural/subarachnoid anesthesia to patients in labor.

Case Description: A 34-year-old G1P0, who underwent resection of an L1-L3 intramedullary ependymoma 8 years previously, presented in active labor with residual left leg numbness and tingling. Read More

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http://dx.doi.org/10.4103/sni.sni_490_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213808PMC
October 2018
1 Read

Intramedullary spinal cord ependymoma and astrocytoma: intraoperative frozen-section diagnosis, extent of resection, and outcomes.

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J Neurosurg Spine 2018 Oct 1:1-7. Epub 2018 Oct 1.

OBJECTIVEThe intraoperative differentiation of ependymomas from astrocytomas is important because neurosurgical strategies differ between these two tumor groups. Previous studies have reported that the diagnostic accuracy of intraoperative frozen sections of intracranial central nervous system (CNS) tumors is higher than 83%-97%, whereas that for spinal intramedullary tumors remains unknown. Herein, authors tested the hypothesis that intraoperative frozen-section diagnosis is the gold standard for a differential diagnosis of intramedullary spinal cord tumors. Read More

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http://dx.doi.org/10.3171/2018.7.SPINE18230DOI Listing
October 2018
2 Reads

Tumor-infiltrating immune cell subpopulations and programmed death ligand 1 (PD-L1) expression associated with clinicopathological and prognostic parameters in ependymoma.

Cancer Immunol Immunother 2019 Feb 27;68(2):305-318. Epub 2018 Nov 27.

Department of Pathology, Asan Medical Center, Seoul, South Korea.

Ependymomas are biologically and clinically heterogeneous tumors of the central nervous system that have variable clinical outcomes. The status of the tumor immune microenvironment in ependymoma remains unclear. Immune cell subsets and programmed death ligand 1 (PD-L1) expression were measured in 178 classical ependymoma cases by immunohistochemistry using monoclonal antibodies that recognized tumor-infiltrating lymphocyte subsets (TILs; CD3, CD4, CD8, FOXP3, and CD20), tumor-associated macrophages (TAMs; CD68, CD163, AIF1), indoleamine 2,3-dioxygenase (IDO)+ cells and PD-L1-expressing tumor cells. Read More

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http://link.springer.com/10.1007/s00262-018-2278-x
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http://dx.doi.org/10.1007/s00262-018-2278-xDOI Listing
February 2019
4 Reads

Microsurgical Gross Total Resection of a WHO Grade II Cerebellopontine Angle Ependymoma in an Adult.

J Neurol Surg B Skull Base 2018 Dec 25;79(Suppl 5):S426-S427. Epub 2018 Sep 25.

Department of Neurological Surgery, University of Wisconsin Medical School, Madison, Wisconsin, United States.

Infratentorial ependymomas that arise in the fourth ventricle and extend into the cerebellopontine angle (CPA) through the foramina of Luschka are well described. However, a primary CPA location of an ependymoma is distinctly uncommon. In this video, we present a 46-year-old man with episodes of dizziness, left-sided tinnitus, imbalance, double vision, and nausea. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1669969
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http://dx.doi.org/10.1055/s-0038-1669969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243230PMC
December 2018
11 Reads

Spinal Cord Injury From Spinal Tumors: Prevalence, Management, and Outcomes.

World Neurosurg 2019 Feb 22;122:e1551-e1556. Epub 2018 Nov 22.

Department of Orthopaedic Surgery, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA. Electronic address:

Background: With the aging population in the United States, it can be anticipated that the prevalence of spinal cord injuries (SCIs) and cancer will increase. Primary or metastatic spine tumors sit at a unique intersection of these 2 realms. Our objective was to evaluate the prevalence, outcomes, and complications after the management of SCI arising from spinal tumors. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.11.099DOI Listing
February 2019
1 Read

Transcriptional co-expression regulatory network analysis for Snail and Slug identifies , an inflammatory cytokine receptor, to be preferentially expressed in ST-EPN- and PF-EPN-A molecular subgroups of intracranial ependymomas.

Oncotarget 2018 Oct 26;9(84):35480-35492. Epub 2018 Oct 26.

Department of Pathology, All India Institute of Medical Sciences, New Delhi-110029, India.

Recent molecular subgrouping of ependymomas (EPN) by DNA methylation profiling has identified ST-EPN- and PF-EPN-A subgroups to be associated with poor outcome. Snail/Slug are cardinal epithelial-to-mesenchymal transcription factors (EMT-TFs) and are overexpressed in several CNS tumors, including EPNs. A systematic analysis of gene-sets/modules co-expressed with and genes using published expression microarray dataset (GSE27279)identified 634 genes for with enriched TGF-β, PPAR and PI3K signaling pathways, and 757 genes for with enriched focal adhesion, ECM-receptor interaction and regulation of actin cytoskeleton related pathways. Read More

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http://dx.doi.org/10.18632/oncotarget.26211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231457PMC
October 2018

Infusion of 5-Azacytidine (5-AZA) into the fourth ventricle or resection cavity in children with recurrent posterior Fossa Ependymoma: a pilot clinical trial.

J Neurooncol 2019 Jan 20;141(2):449-457. Epub 2018 Nov 20.

Developmental and Stem Cell Biology Program, The Arthur and Sonia Labatt Brain Tumour Center, Division of Neurosurgery, Hospital for Sick children, Toronto, ON, Canada.

Background: DNA methylation inhibitors are logical therapeutic candidates for ependymomas originating in the posterior fossa of the brain. Our objective was to test the safety of infusing 5-Azacytidine (5-AZA), a DNA methylation inhibitor, directly into cerebrospinal fluid (CSF) spaces of the fourth ventricle or tumor resection cavity in children with recurrent ependymoma originating in the posterior fossa.

Materials And Methods: In patients with recurrent ependymoma whose disease originated in the posterior fossa, a maximal safe subtotal tumor resection was performed. Read More

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http://dx.doi.org/10.1007/s11060-018-03055-1DOI Listing
January 2019
9 Reads

Craniospinal irradiation as part of re-irradiation for children with recurrent intracranial ependymoma.

Neuro Oncol 2018 Nov 19. Epub 2018 Nov 19.

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.

Background: The goal of this study was to evaluate outcomes in children with relapsed, molecularly-characterized intracranial ependymoma treated with or without craniospinal irradiation (CSI) as part of a course of repeat radiation therapy (re-RT).

Methods: This was a retrospective cohort study of 31 children. Patients with distant relapse received CSI as part of re-RT. Read More

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https://academic.oup.com/neuro-oncology/advance-article/doi/
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http://dx.doi.org/10.1093/neuonc/noy191DOI Listing
November 2018
7 Reads

A case of neurofibromatosis type 2 (NF2) with classic imaging and skin findings.

Med J Armed Forces India 2018 Oct 5;74(4):407-409. Epub 2017 Oct 5.

Classified Specialist (ENT), Command Hospital (Central Command), Lucknow, India.

Neurofibromatosis is a neurocutaneous, tumor predisposing, inheritable disorder characterized by tumors of the brain and spine and the presence of skin lesions. The most important tumors associated with neurofibromatosis are vestibular nerve schwannomas, with others being meningiomas and ependymomas. The cord is also affected by tumors, ependymoma being the commonest, besides meningiomas and schwannomas. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03771237173112
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http://dx.doi.org/10.1016/j.mjafi.2017.07.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224702PMC
October 2018
12 Reads

Long-Term Supratentorial Radiologic Effects of Surgery and Local Radiation in Children with Infratentorial Ependymoma.

World Neurosurg 2019 Feb 16;122:e1300-e1304. Epub 2018 Nov 16.

Department of Radiology, Stanford University School of Medicine, Stanford, California, USA.

Background: Current standard of care for children with infratentorial ependymoma includes maximal safe resection and local radiation of 54-59 Gray. High-dose local radiation has been associated with declines in multiple cognitive domains. The anatomic and physiologic correlates of this cognitive decline remain undefined, and there have been no radiographic studies on the long-term effects of this treatment paradigm. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.11.039DOI Listing
February 2019
3 Reads

Medical cannabis in the UK.

Authors:
Alex Stevens

BMJ 2018 Nov 16;363:k4844. Epub 2018 Nov 16.

University of Kent, Chatham Maritime, Kent, UK.

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http://dx.doi.org/10.1136/bmj.k4844DOI Listing
November 2018

Pediatric ependymoma: current treatment and newer therapeutic insights.

Future Oncol 2018 Nov 12. Epub 2018 Nov 12.

Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.

Advances in genomic, transcriptomic and epigenomic profiling now identifies pediatric ependymoma as a defined biological entity. Molecular interrogation has segregated these tumors into distinct biological subtypes based on anatomical location, age and clinical outcome, which now defines the need to tailor therapy even for histologically similar tumors. These findings now provide reasons for a paradigm shift in therapy, which should profile future clinical trials focused on targeted therapeutic strategies and risk-based treatment. Read More

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https://www.futuremedicine.com/doi/10.2217/fon-2018-0502
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http://dx.doi.org/10.2217/fon-2018-0502DOI Listing
November 2018
17 Reads

Clinicopathologic features of anaplastic myxopapillary ependymomas.

Brain Pathol 2019 01;29(1):75-84

Department of Pathology, University of California, San Francisco, CA.

Myxopapillary ependymomas (MPE) are considered benign (World Health Organization (WHO) grade I) neoplasms with favorable prognosis. However, malignant behavior occurs in a small subset. To our knowledge, only five anaplastic MPEs have been reported without consensus on diagnostic criteria. Read More

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http://doi.wiley.com/10.1111/bpa.12673
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http://dx.doi.org/10.1111/bpa.12673DOI Listing
January 2019
10 Reads
3.840 Impact Factor

Intramedullary schwannoma of conus medullaris: rare site for a common tumor with review of literature.

Spinal Cord Ser Cases 2018 6;4:99. Epub 2018 Nov 6.

3Department of Radiology, Institute of Human Behaviour and Allied Sciences, Delhi, India.

Introduction: Schwannomas at an intramedullary location constitute only 0.3% of primary spinal tumors. Those in the conus are extremely rare, especially in the absence of neurofibromatosis, with only 12 cases reported in the literature so far, excluding the present case. Read More

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http://dx.doi.org/10.1038/s41394-018-0134-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219485PMC
November 2018
1 Read