6,854 results match your criteria Ependymoma


Multisegmental versus monosegmental intramedullary spinal cord ependymomas: perioperative neurological functions and surgical outcomes.

Neurosurg Rev 2021 May 14. Epub 2021 May 14.

Department of Neurosurgery, Peking University Third Hospital, Peking University, Beijing, China.

Multiple factors, such as tumor size, lateralization, tumor location, accompanying syringomyelia, and regional spinal cord atrophy, may affect the resectability and clinical prognosis of intramedullary spinal cord ependymomas. However, whether long-segmental involvement of the spinal cord may impair functional outcomes remains unclear. This study was aimed to compare perioperative neurological functions and long-term surgical outcomes between multisegmental ependymomas and their monosegmental counterparts. Read More

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Cerebrospinal fluid and intraoperative squash cytology of childhood ependymoma.

Acta Biomed 2021 May 12;92(2):e2021107. Epub 2021 May 12.

PEDIATRICIAN ONCOLOGIST.

Ependymomas are glial neoplasms of central nervous system originated from the ependymal lining of the brain ventricles and spinal cord central canal, and rarely exfoliated into cerebrospinal fluid (CSF). In this case we report the cytomorphological and immunocytomorphological features of ependymoma in CSF and intraoperative squash preparations, confirmed by histology. Case report. Read More

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Incidental Discovery of a Presacral Extradural Myxopapillary Ependymoma.

Clin Med Res 2021 May 13. Epub 2021 May 13.

Department of General Surgery, Marshfield Medical Center, Marshfield, WI;

Ependymoma is a malignant central nervous system tumor arising from the lining of the ventricles or central canal of the spinal cord. Extradural spinal ependymomas arise from heterotopic ependymal cells or the coccygeal medullary vestige and are extremely infrequent. We present a rare case of presacral extradural ependymoma. Read More

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Subcutaneous Sacro Coccygeal Myxopapillary Ependymoma: A Case Report and a Comprehensive Review of the Literature Reappraising Its Current Diagnostic Approach and Management.

Cureus 2021 May 10;13(5):e14931. Epub 2021 May 10.

Radiation Oncology, Civil hospital Shillong, Shillong, IND.

Sacrococcygeal myxopapillary ependymoma (MPE) is an uncommon type I glial tumor detected most frequently in the lumbosacral area of adolescents and children. It is usually presented as an intradural ependymal tumor that originates from the filum terminale and other locations within the ventricular system along the craniospinal axis. In rare cases, however, MPE may develop as a primary subcutaneous tumor in the sacrococcygeal area. Read More

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Cerebellar liponeurocytoma, a rare tumor: Case report and review of the literature.

Int J Surg Case Rep 2021 Apr 30;82:105937. Epub 2021 Apr 30.

Makassed Islamic Charitable Society, Jerusalem, Palestine.

Introduction: Cerebellar liponeurocytoma is a rare tumor of the central nervous system occurring mainly in the posterior fossa, which shows neuronal and variable astrocytic differentiation, along with foci of lipomatous differentiation.

Case Presentation: Herein, we describe a 50-year-old female patient who presented to the hospital complaining of headache, tinnitus, and vertigo with positive cerebellar signs. MRI revealed a left cerebellar tumor. Read More

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The role of sex genotype in paediatric CNS tumour incidence and survival.

Childs Nerv Syst 2021 May 5. Epub 2021 May 5.

School of Medicine, University of Leeds, Leeds, LS2 9JT, UK.

Purpose: Evidence exists, in CNS germinomas and medulloblastomas (MB), that patient sex significantly influences incidence and outcome. The role of sex genotype in other paediatric CNS tumours remains unclear. This study sought to examine the role of sex genotype in CNS tumour incidence and overall survival (OS). Read More

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Intraparenchymal subependymoma: Case report and literature review.

Surg Neurol Int 2021 14;12:154. Epub 2021 Apr 14.

Department of Neurosurgery, Antonio Pedro University Hospital, Brazil.

Background: Intracranial subependymomas are rare slow-growing benign tumors typically located in the ventricular system, accounting for 0.07-0.7% of all intracranial neoplasms. Read More

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Intramedullary spinal cord lesions in children.

J Pak Med Assoc 2021 Feb;71(2(B)):775-777

Section of Neurosurgery, Department of Surgery, Aga Khan University Hospital, Karachi.

Paediatric intramedullary spinal cord lesions are uncommon pathologies, prone to result in dismal prognosis if not managed promptly and aggressively. While children usually present in good functional grades compared to adults, early recognition and treatment is important to improve outcomes. In this review, we present tumour demographics, patient factors, and treatment modalities of intramedullary spinal cord lesions in paediatric patients. Read More

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February 2021

Refining the treatment of spinal cord lesions: experience from 500 cases.

Neurosurg Focus 2021 May;50(5):E22

Objective: Tumorous lesions of the spinal cord, as well as some vascular lesions like cavernous hemangiomas, demand careful consideration as to the indication and approach for surgery. As these lesions are rare in any departmental series, refinement of treatment strategies evolves over long periods. In this context, the authors evaluated a series of 500 intramedullary lesions for approach, technique, outcome, complications, and follow-up. Read More

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Ongoing Response in a Multiply Relapsed Metastatic Posterior Fossa Ependymoma A After Vorinostat and Concomitant Irradiation.

J Pediatr Hematol Oncol 2021 Apr 28. Epub 2021 Apr 28.

Division of Pediatric Hematology/Oncology, Children's Hospital of Michigan Central Michigan University School of Medicine Division of Neurosurgery and Pediatric Neurosurgery Department of Pediatrics, Wayne State University School of Medicine Department of Radiation Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University Department of Radiology-Pediatric Neuroradiology, Wayne State University School of Medicine Children's Hospital of Michigan, Detroit Michigan Center for Translational Pathology, University of Michigan Department of Pediatrics, University of Michigan, Ann Arbor Beaumont Children's Hospital, Royal Oak, MI.

Posterior fossa ependymomas A confer the worst prognosis among all subtypes. They demonstrate distinct epigenetic changes, which can be targeted with epigenetic modifiers like histone deacetylase inhibitors (Vorinostat). We describe a 3-year-old male diagnosed with a posterior fossa ependymoma who had a number of recurrences requiring multimodal therapy. Read More

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BLBP Is Both a Marker for Poor Prognosis and a Potential Therapeutic Target in Paediatric Ependymoma.

Cancers (Basel) 2021 Apr 27;13(9). Epub 2021 Apr 27.

Children's Brain Tumour Research Centre, School of Medicine, University of Nottingham Biodiscovery Institute, Nottingham NG7 2RD, UK.

Paediatric ependymomas are aggressive, treatment-resistant tumours with a tendency towards relapse, consistent with a sub-population of therapy-resistant cancer stem cells. These cells are believed to derive from brain lipid binding protein (BLBP)-expressing radial glia, hence we proposed that BLBP may be a marker for ependymoma therapy resistance. BLBP protein expression correlated with reduced overall survival (OS) in patients from two trials (CNS9204, a chemotherapy-led infant trial-5 y OS 45% vs. Read More

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Integrated Metabolomics and Transcriptomics Using an Optimised Dual Extraction Process to Study Human Brain Cancer Cells and Tissues.

Metabolites 2021 Apr 14;11(4). Epub 2021 Apr 14.

Children's Brain Tumour Research Centre, School of Medicine, Biodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, UK.

The integration of untargeted metabolomics and transcriptomics from the same population of cells or tissue enhances the confidence in the identified metabolic pathways and understanding of the enzyme-metabolite relationship. Here, we optimised a simultaneous extraction method of metabolites/lipids and RNA from ependymoma cells (BXD-1425). Relative to established RNA (mirVana kit) or metabolite (sequential solvent addition and shaking) single extraction methods, four dual-extraction techniques were evaluated and compared (methanol:water:chloroform ratios): cryomill/mirVana (1:1:2); cryomill-wash/Econospin (5:1:2); rotation/phenol-chloroform (9:10:1); Sequential/mirVana (1:1:3). Read More

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[Histological profile and progression of intraspinal tumors after surgery].

Pan Afr Med J 2021 4;38:128. Epub 2021 Feb 4.

Service de Neurochirurgie du Centre Hospitalier Universitaire Yalgado Ouédraogo de Ouagadougou, Ouagadougou, Burkina Faso.

Intraspinal tumors are uncommon. Positive diagnosis is based on medical imaging exams, in particular MRI. Anatomopathological examination allows for definitive diagnosis. Read More

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Diffusion MRI in Evaluation of Pediatric Posterior Fossa Tumors.

Asian Pac J Cancer Prev 2021 Apr 1;22(4):1129-1136. Epub 2021 Apr 1.

Department of Radiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Background: To evaluate the role of diffusion MRI in differentiating pediatric posterior fossa tumors and determine the cut-off values of ADC ratio to distinguish medulloblastoma from other common tumors.

Methods: We retrospectively reviewed MRI of 90 patients (7.5-year median age) with pathologically proven posterior fossa tumors (24 medulloblastoma, 7 ependymoma, 4 anaplastic ependymoma, 13 pilocytic astrocytoma, 30 diffuse intrinsic pontine glioma (DIPG), 4 ATRT, 3 diffuse astrocytoma, 2 high grade astrocytoma, 2 glioblastoma, and 1 low grade glioma). Read More

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A coordinated approach for the assessment of molecular subgroups in pediatric ependymomas using low-cost methods.

J Mol Med (Berl) 2021 Apr 26. Epub 2021 Apr 26.

Department of Paediatrics, Ribeirão Preto Medical School, 3900 Bandeirantes Avenue, Ribeirão Preto, SP, 14049-900, Brazil.

Although ependymoma (EPN) molecular subgroups have been well established by integrated high-throughput platforms, low- and middle-income countries still need low-cost techniques to promptly classify these molecular subtypes. Here, we applied low-cost methods to classify EPNs from a Brazilian cohort with 60 pediatric EPN patients. Fusion transcripts (C11orf95-RELA, YAP1-MAMLD1, and YAP1-FAM118B) were investigated in supratentorial EPN (ST-EPNs) samples through RT-PCR/Sanger sequencing and immunohistochemistry (IHC) for p65/L1CAM. Read More

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Identification of key methylation differentially expressed genes in posterior fossa ependymoma based on epigenomic and transcriptome analysis.

J Transl Med 2021 04 26;19(1):174. Epub 2021 Apr 26.

Department of Neurosurgery, Xijing Hospital, Airforce Military Medical University (Fourth Military Medical University), Xi'an, 710032, China.

Background: Posterior fossa ependymoma (EPN-PF) can be classified into Group A posterior fossa ependymoma (EPN-PFA) and Group B posterior fossa ependymoma (EPN-PFB) according to DNA CpG island methylation profile status and gene expression. EPN-PFA usually occurs in children younger than 5 years and has a poor prognosis.

Methods: Using epigenome and transcriptome microarray data, a multi-component weighted gene co-expression network analysis (WGCNA) was used to systematically identify the hub genes of EPN-PF. Read More

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Sequential Orbitrap Secondary Ion Mass Spectrometry and Liquid Extraction Surface Analysis-Tandem Mass Spectrometry-Based Metabolomics for Prediction of Brain Tumor Relapse from Sample-Limited Primary Tissue Archives.

Anal Chem 2021 May 26;93(18):6947-6954. Epub 2021 Apr 26.

Advanced Materials & Healthcare Technologies Division, School of Pharmacy, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.

We present here a novel surface mass spectrometry strategy to perform untargeted metabolite profiling of formalin-fixed paraffin-embedded pediatric ependymoma archives. Sequential Orbitrap secondary ion mass spectrometry (3D OrbiSIMS) and liquid extraction surface analysis-tandem mass spectrometry (LESA-MS/MS) permitted the detection of 887 metabolites (163 chemical classes) from pediatric ependymoma tumor tissue microarrays (diameter: <1 mm; thickness: 4 μm). From these 163 classes, 60 classes were detected with both techniques, whilst LESA-MS/MS and 3D OrbiSIMS individually allowed the detection of another 83 and 20 unique metabolite classes, respectively. Read More

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Challenges in diagnosis and management of adult spinal cord gliomas.

Rev Neurol (Paris) 2021 Apr 22. Epub 2021 Apr 22.

Hôpital de la Timone, Marseille, France.

Intramedullary spinal cord gliomas have very low incidence rates. They are associated with difficulties in diagnosis and treatment, and cause significant morbidity. Their clinical presentation and their appearance at magnetic resonance imaging are not specific. Read More

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Brain Ependymoma in an African Grey Parrot ().

J Avian Med Surg 2021 Apr;35(1):75-79

FauneVET, 22 rue René Viviani 44200 Nantes, France.

A 14-year-old unsexed African grey parrot () was presented with a 12-hour history of neurological signs and vomiting. The external physical examination of the patient revealed lethargy, moderate hypothermia, a head tilt, and horizontal nystagmus. Whole-body radiographic imaging and blood biochemistry parameters were unremarkable, and a serological test to detect bornavirus was negative. Read More

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Phase II and biomarker study of programmed cell death protein 1 inhibitor nivolumab and metronomic cyclophosphamide in paediatric relapsed/refractory solid tumours: Arm G of AcSé-ESMART, a trial of the European Innovative Therapies for Children With Cancer Consortium.

Eur J Cancer 2021 Apr 20;150:53-62. Epub 2021 Apr 20.

Department of Pediatric and Adolescent Oncology, Gustave Roussy Cancer Campus, Université Paris-Saclay, Villejuif, France; INSERM U1015, Gustave Roussy Cancer Campus, Université Paris-Saclay, Villejuif, France. Electronic address:

Purpose: AcSé-ESMART is a European multicentre, proof-of-concept multiarm phase I/II platform trial in paediatric patients with relapsed/refractory cancer. Arm G assessed the activity and safety of nivolumab in combination with metronomic cyclophosphamide +/- irradiation.

Experimental Design: Following a Phase II Simon two-stage design, nivolumab was administered intravenously at 3 mg/kg every 2 weeks of a 28-day cycle, oral cyclophosphamide at 25 mg/m twice a day, 1 week on/1 week off. Read More

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A phase 1 study of prexasertib (LY2606368), a CHK1/2 inhibitor, in pediatric patients with recurrent or refractory solid tumors, including CNS tumors: A report from the Children's Oncology Group Pediatric Early Phase Clinical Trials Network (ADVL1515).

Pediatr Blood Cancer 2021 Apr 21:e29065. Epub 2021 Apr 21.

Center for Cancer and Blood Disorders, Phoenix Children's Hospital, Institute for Molecular Medicine, Department of Child Health, University of Arizona College of Medicine-Phoenix, Phoenix, Arizona.

Background: Prexasertib (LY2606368) is a novel, second-generation, selective dual inhibitor of checkpoint kinase proteins 1 (CHK1) and 2 (CHK2). We conducted a phase 1 trial of prexasertib to estimate the maximum-tolerated dose (MTD) and/or recommended phase 2 dose (RP2D), to define and describe the toxicities, and to characterize the pharmacokinetics (PK) of prexasertib in pediatric patients with recurrent or refractory solid and central nervous system (CNS) tumors.

Methods: Prexasertib was administered intravenously (i. Read More

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Surgical management of a rare myxopapillary ependymoma of the gluteal region: A case report.

Surg Neurol Int 2021 30;12:130. Epub 2021 Mar 30.

Department of Neurological Surgery, University of California, UCI Medical Center, Orange, United States.

Background: Ependymomas are rare tumors originating from neuroepithelial cells lining the wall of the ventricles or central canal of the spinal cord. While these tumors mainly occur within the central nervous system (CNS), there are occasional reports in children and young adult patients with a primary tumor occurrence outside of the CNS. Ependymomas of the sacrococcygeal region have been infrequently described in the literature with no standard of care established. Read More

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[Synchronous schwannoma and ependymoma of the cauda equina].

Zh Vopr Neirokhir Im N N Burdenko 2021 ;85(2):75-79

Military Medical Academy named after S.M. Kirov of the Ministry of Defense of the Russian Federation, Saint Petersburg, Russia.

The article presents a case of surgical treatment of primary multiple benign tumors of the cauda equine of different histological origin: spinal nerve root schwannoma and ependymoma of the filum terminale. Read More

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Bone-to-bone ligament preserving laminoplasty technique for reconstruction of laminae.

J Craniovertebr Junction Spine 2021 Jan-Mar;12(1):61-64. Epub 2021 Mar 4.

Department of Neurosurgery, University of Health Sciences, Istanbul, Turkey.

Introduction: Laminoplasty is a method used in spinal intradural tumor surgery to reduce the possibility of iatrogenic deformity. In classic laminoplasty, the interspinous, supraspinous, and ligamentum flavum integrity may be impaired, thereby creating a risk of deformity despite the laminoplasty. The aim of this study was to review the outcomes of bone-to-bone ligament preserving laminoplasty (BLP laminoplasty) technique. Read More

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The Survival Benefits of Surgical Resection and Adjuvant Therapy for Patients With Brainstem Glioma.

Front Oncol 2021 25;11:566972. Epub 2021 Mar 25.

Department of Neurosurgery, Xiangya Hospital, Center South University, Changsha, China.

Purpose: The role of surgical resection in the treatment of brainstem glioma (BSG) is poorly understood. For pediatric low-grade (LGBSG) group, several monocentric small-scale retrospective studies reported contradictory conclusions. And there was no clinical study focused on surgical resection for adult or pediatric high-grade (HG) patient groups. Read More

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Adjunctive treatment of myxopapillary ependymoma.

Oncol Rev 2021 Feb 17;15(1):518. Epub 2021 Mar 17.

Neurosurgery Department, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Myxopapillary ependymoma are rare tumors and optimal therapeutic strategy is remained controversial. The main treatments for myxopapillary ependymoma tumors include surgery and radiotherapy. Hence, the present study aimed to review adjuvant treatment of myxopapillary ependymoma, focusing on spinal myxopapillary ependymoma. Read More

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February 2021

Comparison of ependymomas and medulloblastomas located in the posterior cranial fossa: An anatomical and histopathological study.

Arch Ital Biol 2020 12;158(3-4):74-81

Department of Neurosurgery, Faculty of Medicine, University of Dicle, 21280, Diyarbakır, Turkey - Email:

Posterior fossa tumors (PFTs) include medulloblastomas, atypical teratoid/rhabdoid tumors, pilocytic astrocytomas, ependymomas, and brainstem gliomas. We evaluated patients with surgery at our clinic, comparing epidemiological, clinical, radiological, and pathological characteristics of medulloblastoma and ependymoma to identify factors that might assist preoperative diagnosis, help to develop treatment algorithms, and have prognostic value after surgery. Pediatric patients from 0 to 16 and young adults from 16 to 29 years of age with surgery for pathologically confirmed ependymomas or medulloblastomas between January 2014 and January 2020 were eligible. Read More

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December 2020

Feasibility of Proton Beam Therapy for Infants with Brain Tumours: Experiences from the Prospective KiProReg Registry Study.

Clin Oncol (R Coll Radiol) 2021 Apr 2. Epub 2021 Apr 2.

Department of Particle Therapy, University Hospital Essen, West German Proton Therapy Centre Essen, West German Cancer Centre, Essen, Germany; Department of Particle Therapy, University Hospital Essen, West German Proton Therapy Centre Essen (WPE), West German Cancer Center (WTZ), German Cancer Consortium (DKTK), Essen, Germany.

Aims: Proton beam therapy (PBT) has increasingly been applied for the treatment of young children when radiotherapy is needed. The treatment requires intensive multimodality care and is logistically demanding. In this analysis, we evaluated our experiences in treating infants with tumours of the central nervous system with PBT. Read More

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Recent Advances in Understanding the Role of Autophagy in Paediatric Brain Tumours.

Diagnostics (Basel) 2021 Mar 9;11(3). Epub 2021 Mar 9.

Department of Pediatric Hemato-Oncology and Cell and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.

Autophagy is a degradative process occurring in eukaryotic cells to maintain homeostasis and cell survival. After stressful conditions including nutrient deprivation, hypoxia or drugs administration, autophagy is induced to counteract pathways that could lead to cell death. In cancer, autophagy plays a paradoxical role, acting both as tumour suppressor-by cleaning cells from damaged organelles and inhibiting inflammation or, alternatively, by promoting genomic stability and tumour adaptive response-or as a pro-survival mechanism to protect cells from stresses such as chemotherapy. Read More

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