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Intern Med 2020 Jun 15. Epub 2020 Jun 15.

Departments of Gastroenterology, National Hospital Organization Hakodate National Hospital, Japan.

Eosinophilic gastroenteritis (EGE)-associated duodenal ulcer is rare and its endoscopic and pathological features remain poorly described. A 15-year-old boy was referred to our hospital for further examination and treatment of duodenal ulcer. Esophagogastroduodenoscopy (EGD) revealed two A2-stage duodenal ulcers on the duodenal bulb. Read More

Clin Case Rep 2020 May 3;8(5):804-807. Epub 2020 Mar 3.

Mazandaran University of Medical Sciences Sari Iran.

Eosinophilic ulcer (EU) is a rare self-limiting chronic benign lesion of the oral mucosa. It is an uncommon and benign disease, which may leading to diagnostic difficulties. Biopsy is recommended to rule out any malignant etiology. Read More

J Pathol Transl Med 2020 Jul 22;54(4):332-335. Epub 2020 May 22.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Goyang.

Crystal-storing histiocytosis (CSH) is a rare entity that is characterized by intrahistiocytic accumulation of crystallized immunoglobulins. CSH is not a malignant process per se, but the majority of CSH cases are associated with underlying lymphoproliferative disorder. Although CSH can occur in a variety of organs, gastric CSH is very rare. Read More

Cureus 2020 Feb 20;12(2):e7059. Epub 2020 Feb 20.

Internal Medicine, Avnentura Hosptial and Medical Center, Aventura, USA.

Eosinophilic gastroenteritis (EGE) is a rare idiopathic disease affecting multiple organs (stomach and small intestine) of the digestive tract. It is characterized by eosinophilic infiltration of the bowel wall to a variable depth and symptoms associated with gastrointestinal tract disease. The prevalence of this condition is ranging from 8 and 28 per 100,000. Read More

Cardiovasc Pathol 2020 Jul - Aug;47:107193. Epub 2019 Dec 18.

Department of Cellular and Organ Pathology, Graduate School of Medicine, Akita University, Akita, Japan.

Eosinophilic granulomatosis with polyangiitis (EGPA), formerly called Churg-Strauss syndrome, is an uncommon disease with pathological features consisting of systemic necrotizing vasculitis, eosinophilic infiltration, and granulomatous or nongranulomatous extravascular eosinophilic inflammation. EGPA preferentially affects certain organ systems, including the airways, peripheral nerves, heart, kidney, and gastrointestinal tract. Although gastrointestinal involvement, such as ulcerations, is common in EGPA, gastrointestinal perforation is relatively uncommon and is associated with a poor prognosis. Read More

Clin Med (Lond) 2020 01;20(1):107-109

Prince of Wales Hospital, Hong Kong

Ion-exchange resins, sodium or calcium polystyrene sulfonate, are commonly used medications for management of hyperkalaemia. However, the drug can be associated with serious bowel injury. We report a case of a renal transplant recipient who developed duodenal ulcer perforation secondary to the use of calcium polystyrene sulfonate. Read More

World J Surg Oncol 2019 Nov 9;17(1):184. Epub 2019 Nov 9.

Department of Oral and Craniomaxillofacial Surgery, University Hospital Basel, Spitalstrasse 21, CH-4031, Basel, Switzerland.

Background: Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is a rare self-limiting condition of the oral mucosa. The lesion manifests as an isolated ulcer that can be either asymptomatic or associated with mild to severe pain, and in most cases, it affects the tongue. TUGSE lesions may mimic malignancy such as squamous cell carcinoma, CD30 positive lymphoproliferative disorder, or infectious diseases such as primary syphilis, tuberculosis, or Epstein-Barr virus mucocutaneous ulcer. Read More

Am J Dermatopathol 2020 Jul;42(7):506-512

Departments of Histopathology and Dermatology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Background: Granulomatous dermatitis due to noncontiguous involvement of Crohn disease (CD) of the gut has been described as metastatic CD (MCD). MCD is the rarest form of cutaneous manifestations of CD. This study aims to analyze the clinicohistological features of MCD in a tertiary care center of India. Read More

Endosc Int Open 2019 Nov 22;7(11):E1333-E1343. Epub 2019 Oct 22.

Division of Gastroenterology, Iwate Medical University, Morioka, Japan.

 Among vasculitides, IgA vasculitis (IgAV) and eosinophilic granulomatosis with polyangiitis (EGPA) frequently damage the gastrointestinal tract. However, only a few studies have investigated the entire gastrointestinal tract in patients with IgAV or EGPA by endoscopy. The aim of this study was to clarify endoscopic characteristics of patients with IgAV and those with EGPA. Read More

Aerosp Med Hum Perform 2019 Nov;90(11):986-988

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Case Rep Rheumatol 2019 2;2019:9053747. Epub 2019 Sep 2.

Department of Diagnostic Pathology, Seirei Mikatahara Hospital, 3453 Mikataharacho, Hamamatsu 433-8558, Japan.

In children, acute pancreatitis has been reported in IgA vasculitis, Kawasaki disease, systemic lupus erythematosus-associated vasculitis, and juvenile dermatomyositis-associated vasculitis. However, its frequency in these vasculitides has been shown to be low. In other childhood-onset vasculitides, acute pancreatitis is seldom reported. Read More

Helicobacter 2019 Sep;24 Suppl 1:e12637

Medical Department II, University Hospital, LMU, Munich, Germany.

This review covers recent publications investigating the relationship between Helicobacter pylori infection and gastroesophageal reflux disease, Barrett's esophagus, eosinophilic esophagitis, peptic ulcer disease (PUD), H pylori gastritis, and functional dyspepsia. In the area of gastroesophageal reflux disease, new data suggest that reflux may have a role in the transmission of H pylori infection. In addition to several observational studies, data on alterations in esophageal physiology in patients with H pylori infection are presented. Read More

Rev Med Interne 2020 Jan 29;41(1):50-53. Epub 2019 Aug 29.

Service de chirurgie maxillo-faciale et stomatologie, centre hospitalo-universitaire de Rouen, 1, rue de Germont, 76000 Rouen, France; Laboratoire d'anatomie, faculté de médecine de Rouen, 22, boulevard Gambetta, 76000 Rouen, France; Institut national de la santé et de la recherche médicale (Inserm), LIMICS UMR-1142, 76000 Rouen, France. Electronic address:

Introduction: Langerhans cell histiocytosis (HL) is a rare disease that can affect all tissues. Oral manifestations such as mucosal ulcer and tooth mobility are often the first signs of the disease. We report a rare case of mandibular condyle unifocal HL mimicking a temporomandibular joint disorder. Read More

BMC Oral Health 2019 08 15;19(1):186. Epub 2019 Aug 15.

Dipartimento di Medicina e Chirurgia, Reparto di Patologia e Chirurgia Orale Laser, Centro Universitario di Odontoiatria, Università di Parma, via Gramsci 14, 43126, Parma, Italy.

Background: The etiology of traumatic ulcerative granulomas with stromal eosinophilia (TUGSE) is not clear, traumatic irritation having advocated as the most likely cause. TUGSEs are typically self-limiting slow-healing lesions of the oral mucosa with unclear pathogenesis, commonly manifesting as a rapidly developing, long-lasting ulcer.

Case Presentation: Here we report a controversial case of a self-healing lesion of the tongue in a 57 year-old woman. Read More

Nihon Shokakibyo Gakkai Zasshi 2019 ;116(8):668-675

First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi.

Eosinophilic gastroenteritis is a rare disease that causes various abdominal symptoms that result from the infiltration of eosinophils in the digestive tract. However, this condition has been poorly explored, and the treatment criteria and prognosis after treatment are still unclear. A 20-year-old man with a refractory duodenal ulcer had been undergoing treatment since 14 years of age at another hospital. Read More

Urol Case Rep 2019 Sep 17;26:100970. Epub 2019 Jul 17.

Saint Francis Memorial Hospital, 900 Hyde Street, San Francisco, CA, 94109, USA.

Eosinophilic cystitis is a rare disease of the bladder, for which there is no clear cause or standard treatment. We report the case of a 61 year old man who presented with irritative voiding symptoms and gross hematuria. Cystoscopy showed diffuse urothelial erythema and a posterior bladder wall ulcer. Read More

Kardiologiia 2019 Jul 19;59(7):31-36. Epub 2019 Jul 19.

Institute of Immunology Federal Medical-Biological Agency of Russia.

Objective: to study clinical and cluster features of cardiovascular burdening taking into account the comorbid polymorbid background in patients of middle age (45-60 years) with the presence of multifocal atherosclerosis (MFA).

Materials And Methods: Patients were examined in the Regional Vascular Center of Ufa (RVCU). Depending on the predominant localization of lesions in the vascular bed patients were divided into 3 clusters by the method of hierarchical analysis of categorical variables according to the clinical manifestation of atherosclerotic lesions of the heart, brain and lower limb arteries confirmed by coronary angiography, ultrasound Doppleroscopy of main arteries of the head and lower extremities. Read More

Dtsch Med Wochenschr 2019 07 28;144(13):893-896. Epub 2019 Jun 28.

Knappschaftskrankenhaus Bottrop, akademisches Lehrkrankenhaus der Universität Duisburg-Essen.

Eosinophilic Gastrointestinal Disease (EGID) is a rare disease of largely unknown etiology. We describe a case of a 79-year-old patient with the initial diagnosis of eosinophilic gastritis with a haemorrhagic-ulcerous course and a rapid recurrence of the disease after discontinuing drug therapy.

Anamnesis And Clinical Findings: The patient stated that he had melena for several days. Read More

Heart Asia 2019 5;11(2):e011211. Epub 2019 Jun 5.

Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan.

A 59-year-old man with hypertension, dyslipidemia and a current smoking history had presented with bilateral painful finger ulcers (figure 1A). The patient was referred to our hospital for the diagnosis and treatment. On his arrival, his fingers showed the development from ulcer to necrosis during the 3 weeks (figure 1B). Read More

BMJ Case Rep 2019 Jun 21;12(6). Epub 2019 Jun 21.

Department of Ophthalmology, Royal Victoria Eye and Ear Hospital, Dublin, Ireland.

Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare antineutrophil cytoplasmic antibody-associated vasculitis that can affect any organ system. It is most often characterised by chronic airway inflammation along with prominent peripheral blood eosinophilia, although the disease can affect the cardiovascular, gastrointestinal, renal or central nervous systems. Ocular manifestations are uncommon and when they do occur, are varied in their clinical presentations. Read More

BMJ Case Rep 2019 Jun 18;12(6). Epub 2019 Jun 18.

Department of Medicine, Lagos State University Teaching Hospital, Lagos, Nigeria.

Eosinophilic granulomatosis with polyangiitis (EGPA), previously called Churg-Strauss Syndrome, is a systemic autoimmune disease that is usually associated with asthma and eosinophilia. It is a rare condition associated with antineutrophil cytoplasmic antibodies (ANCA). We report a case of a 52-year-old Nigerian woman who presented with bilateral leg swelling with multiple ulcers, background history of allergic rhinitis and chronic sinusitis since adolescence. Read More

J Dermatol 2019 10 3;46(10):e377-e378. Epub 2019 May 3.

Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

BMJ Case Rep 2019 Apr 24;12(4). Epub 2019 Apr 24.

Oral and Maxillofacial Surgery, Queen Victoria Hospital NHS Foundation Trust, East Grinstead, UK.

Gingival pathology is a daily presentation, however a small number of systemic conditions can manifest similar to a common gingival condition and have fatal results. Dentist referred 56-year-old woman to Oral and Maxillofacial Surgery department with a 2-week medical history of gingival bleeding not responding to local measures. Biopsy showed eosinophilic infiltrate and vasculitis, and blood tests showed positive markers including cytoplasmic antineutrophil cytoplasmatic antibodies. Read More

J Vet Med Sci 2019 Jun 18;81(6):821-823. Epub 2019 Apr 18.

Iwate University Small Animal Veterinary Internal Science, 18-8 Ueda 3-chome Morioka, Iwate 020-8550, Japan.

A 12-year-old, male miniature dachshund has an ulcer on the footpad of the right hind limb. Despite treatment for longer than 6 months, the ulcer did not heal. Biopsy of the lesion was done to make a definitive diagnosis. Read More

G Ital Dermatol Venereol 2019 Feb 4. Epub 2019 Feb 4.

Dermatology, Department of Specialized, Diagnostic and Experimental Medicine, University of Bologna, Bologna, Italy.

Vet Ophthalmol 2019 Jul 31;22(4):510-519. Epub 2019 Jan 31.

Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, California.

Objective: (a) To evaluate the epidemiology of equine eosinophilic keratoconjunctivitis (EK) in the western United States, (b) to ascertain the efficacy of keratectomy and diamond burr debridement vs medical management alone, (c) to determine the efficacy of various medical therapies, and (d) to further characterize the histopathologic findings of the disease in horses.

Animals Studied: Twenty-nine horses (47 eyes) diagnosed with EK from 1993 to 2017.

Procedure: Retrospective medical record review; owner questionnaire. Read More

Rev Pneumol Clin 2018 12 24;74(6):516-519. Epub 2018 Nov 24.

Service de pneumologie, CHL, Strassen, Luxembourg.

Gastroenterol Hepatol (N Y) 2018 Mar;14(3):169-175

Dr Khan is a third year gastroenterology fellow and Dr Howden is the Hyman Professor of Medicine and Chief of the Division of Gastroenterology at the University of Tennessee Health Science Center in Memphis, Tennessee.

Proton pump inhibitors (PPIs) have been in use since the early 1990s and play a crucial role in the management of a number of conditions affecting the upper gastrointestinal tract, including gastroesophageal reflux disease, Barrett esophagus, eosinophilic esophagitis, and dyspepsia. PPIs also play an important role in the treatment of infection and in the prevention of upper gastrointestinal tract ulcers and bleeding among patients taking antiplatelet therapy and/or nonsteroidal anti-inflammatory drugs. Despite recent concerns regarding the long-term safety of PPIs, their risk-benefit profiles strongly favor their appropriate use in patients who have genuine indications for them. Read More

Indian J Pathol Microbiol 2018 Apr-Jun;61(2):255-257

Department of General Pathology, Christian Medical College, Vellore, Tamil Nadu, India.

Epstein-Barr virus-positive mucocutaneous ulcer (EBVMCU) comprises part of the spectrum of B-cell lymphoproliferative disorders, reported in settings of immunosenescence and iatrogenic immunosuppression, affecting the oropharyngeal mucosa, skin, and gastrointestinal tract. We report a case of a 59-year-old female, known case of rheumatoid arthritis on methotrexate (MTX) for 15 years, who presented with an ulcer in the inner aspect of her cheek region for 2 years. Clinical examination revealed an infiltrative lesion involving the lower gingivobuccal sulcus of size 2 cm × 3 cm extending to the alveolus with level I lymph nodes, suspicious for carcinoma buccal mucosa. Read More

Vet Dermatol 2018 Jun 6;29(3):258-e96. Epub 2018 Apr 6.

Department of Veterinary Medicine, University of Perugia, Via San Costanzo 4, 06126, Perugia, Italy.

Background: Feline herpesvirus ulcerative dermatitis is an uncommon skin disease in cats, with a predominantly facial distribution characterized by massive infiltration of eosinophils and, occasionally, predominant neutrophils.

Objective: To describe the clinical and histopathological features of a putative atypical case of feline herpesvirus dermatitis.

Animal: A 10-month-old, intact male, European cat was presented with chronic monolateral ulcerative dermatitis with adherent crusts on the left pinna. Read More

Gastroenterology 2018 04 8;154(5):1209-1214. Epub 2018 Mar 8.

Division of Gastroenterology, Northwestern University Feinberg School of Medicine, Chicago, Illinois. Electronic address:

Open Dent J 2018 29;12:19-23. Epub 2018 Jan 29.

Department of Stomatology, Oral Medicine Division, School of Dentistry, University of São Paulo, São Paulo, SP. Brazil.

Objective: This article describes a case of an Oral Eosinophilic Ulcer (OEU) in an otherwise healthy 31-year-old white woman.

Introduction: The importance of reporting this case was the presence of recurrent episodes with lesions appearing in different areas of the oral mucosa, a type of manifestation not commonly associated with this disease. A typical manifestation of OEU occurs as a single ulceration that goes into healing after an incisional biopsy, a procedure usually required for a proper diagnosis of the disease. Read More

Biol Trace Elem Res 2018 Sep 4;185(1):36-47. Epub 2018 Jan 4.

Department of Pathology and Oncology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan.

Lanthanum (La) carbonate (LC) is one of the most potent phosphate binders that prevents the elevation of serum phosphate levels in patients with end-stage renal diseases undergoing dialysis. LC binds strongly to dietary phosphate and forms insoluble complexes that pass through the gastrointestinal tract. La deposition in patients treated with LC is a recently documented finding particularly observed in gastric mucosa. Read More

J Nippon Med Sch 2017 ;84(6):286-290

Department of Dermatology, Nippon Medical School.

A 72-year-old man was referred to our hospital for treatment of an ulcer that had been growing on his back for 10 years. Physical examination showed an ulcerated tumor from the neck to the back and swollen cervical lymph nodes. The tumor size was 12×9 cm. Read More

Ann Diagn Pathol 2017 Dec 16;31:50-55. Epub 2017 Jun 16.

Weill Cornell Medicine, 1300 York Ave, New York, NY 10065, USA. Electronic address:

Eosinophilic ulcer of the oral mucosa (EUOM) is a rare, benign, self-resolving lymphoproliferative disorder, which typically presents with asymptomatic to mildly tender ulcers. Histological findings of EUOM are characterized by a polymorphic infiltrate with many eosinophils often extending into the underlying muscle. Although this entity is well documented within the dental literature, it is not well known to physicians. Read More

J Dermatol 2018 Feb 15;45(2):220-223. Epub 2017 Nov 15.

Department of Dermatology, Kansai Medical University Medical Center, Osaka, Japan.

Case 1 was a 75-year-old Japanese man who presented with a poorly demarcated, dark-red nodule with a destructive defect in the center, measuring 3 cm × 2 cm on the right wing of his nose. The histological diagnosis was a common form of infundibular squamous cell carcinoma. Atypical neoplastic cells radiated from the wall of a follicular infundibulum. Read More

Eur J Dermatol 2018 02;28(1):97-99

Department of Dermatology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan.

Clin Endosc 2018 May 26;51(3):285-288. Epub 2017 Oct 26.

Department of Internal medicine, Digestive Disease Research Institute, Wonkwang University College of Medicine, Iksan, Korea.

Esophagogastroduodenoscopy for cancer screening was performed in a 55-year-old woman as part of a health screening program, and revealed a depressed lesion approximately 20 mm in diameter in the lesser curvature of the mid-gastric body. Several biopsy specimens were collected as the lesion resembled early gastric cancer; however, histopathologic evaluation revealed chronic active gastritis with an ulcer and amorphous eosinophilic material deposition. Congo red staining identified amyloid proteins, and apple-green birefringence was shown using polarized light microscopy. Read More

Cutis 2017 Aug;100(2):E28-E31

Wilford Hall Ambulatory Surgical Center, San Antonio Uniformed Services Health Education Consortium, Texas, USA.

Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is an underreported diagnosis in dermatologic literature. Rapid expansion with an ulcerative clinical appearance often provokes fear of malignancy despite its benign nature. Traumatic ulcerative granuloma with stromal eosinophilia is thought to be a reactive tissue response to trauma, but CD30 mononuclear cells within a TUGSE lesion suggests the possibility of an underlying lymphoproliferative disorder. Read More

J Oral Maxillofac Pathol 2017 May-Aug;21(2):321

Department of Oral Pathology and Microbiology, Saraswati Dental College, Lucknow, Uttar Pradesh, India.

Eosinophilic ulcer (EU) is a rare self-limiting chronic benign ulcerative lesion of the oral mucosa often misdiagnosed as oral malignancy. Its etiopathogenesis is ambiguous, but trauma plays an important role in the development. Microscopically, it is characterized by a polymorphic inflammatory infiltrate with a prominent eosinophilic component and large mononuclear cells extending deep into the submucosa, underlying muscle and salivary glands. Read More

Medicine (Baltimore) 2017 Sep;96(37):e8075

aDepartment of Gastroenterology and Hepatology, Jinling Hospital, School of Medicine, Southern Medical University bDepartment of Gastroenterology and Hepatology, Jinling Hospital cDepartment of Gastroenterology and Hepatology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu, China.

Rationale: Eosinphilic gastroenteritis (EG) is a gastrointestinal disorder characterized by eosinophilic infiltration with various manifestations. The diagnosis is usually confirmed by an endoscopic biopsy, which is considered a safe and routine procedure for the majority.

Patient Concerns: We report a 54-year-old male who was presented with intermittent periumbilical pain and melena, and only revealed verrucous gastritis by endoscopy. Read More

Helicobacter 2017 Sep;22 Suppl 1

Institute of Clinical and Preventive Medicine & Faculty of Medicine, University of Latvia, Riga, Latvia.

A substantial decrease in Helicobacter pylori-associated peptic ulcer disease has been observed during the last decades. Drug-related ulcers as well as idiopathic ulcers are becoming predominant and are more refractory to treatment; however, H. pylori infection still plays an important role in ulcer bleeding and recurrence after therapy. Read More

Rev Med Suisse 2017 Jan;13(544-545):49-53

Service de gastroentérologie et hépatologie, HUG, 1211 Genève 14.

This article aims to detail the major innovations occurred in Gastro-enterology in 2016, including the introduction of a new molecule, the vonoprazan, for the treatment of refractory gastroesophagal reflux disease (GERD) and a new way of eradication of H. pylori. The possibility to use an intermittent dose of PPI rather than continuously in severe gastric and duodenal ulcers after successful endoscopic hemostasis is also discussed as well as the withdrawal of corticosteroids in the treatment of autoimmune pancreatitis. Read More

J Dermatol 2017 Sep 30;44(9):e216-e217. Epub 2017 May 30.

Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.

Bladder Cancer 2017 Apr 27;3(2):133-138. Epub 2017 Apr 27.

Department of Urology, University of Michigan Health System, Ann Arbor, MI, USA.

A post-bladder tumor resection dose of MMC can reduce non-invasive papillary (pTa) bladder cancer recurrences by up to 40%; this treatment is recommended in both the AUA and EUA non-muscle-invasive bladder cancer guidelines. A common complication of this treatment is eosinophilic cystitis. Symptoms range from mild urinary frequency and urgency to debilitating pain and dysuria. Read More

J Fish Dis 2017 Oct 23;40(10):1341-1350. Epub 2017 Jan 23.

Wildlife, Exotic and Aquatic Pathology- Special Task Force for Activating Research, Department of Veterinary Pathology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand.

In 2013, an outbreak of ulcerative disease associated with ranavirus infection occurred in barcoo grunter, Scortum barcoo (McCulloch & Waite), farms in Thailand. Affected fish exhibited extensive haemorrhage and ulceration on skin and muscle. Microscopically, the widespread haemorrhagic ulceration and necrosis were noted in gill, spleen and kidney with the presence of intracytoplasmic eosinophilic inclusion bodies. Read More

Gastroenterol Hepatol Bed Bench 2017 ;10(Suppl1):S161-S164

Behbood Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Eosinophilic gastroenteritis is a rare inflammatory disease, defined by infiltration of eosinophils in gastrointestinal (GI) tract, but the etiology of this disorder is unknown. Depends on the involvement region of Eosinophilic gastroenteritis, GI symptoms are variable including abdominal pain, malabsorption, gastric and duodenal ulcer. Due to its non-specific symptoms, the diagnosis is based on upper GI endoscopy followed by histopathological examination of the biopsies, which shows eosinophilic infiltration in different layers of GI tract. Read More

BMC Med 2016 11 9;14(1):179. Epub 2016 Nov 9.

Division of Pharmacology, Department of Clinical & Experimental Medicine, University of Pisa, Pisa, Italy.

Background: The introduction of proton pump inhibitors (PPIs) into clinical practice has revolutionized the management of acid-related diseases. Studies in primary care and emergency settings suggest that PPIs are frequently prescribed for inappropriate indications or for indications where their use offers little benefit. Inappropriate PPI use is a matter of great concern, especially in the elderly, who are often affected by multiple comorbidities and are taking multiple medications, and are thus at an increased risk of long-term PPI-related adverse outcomes as well as drug-to-drug interactions. Read More

Pediatr Transplant 2016 Nov 13;20(7):994-999. Epub 2016 Jul 13.

Hepatology and Liver Transplantation, Hospital Sirio-Libanes, Sao Paulo, SP, Brazil.

The association between LT and gastrectomy is not common. Only two studies reported the gastrectomy/LT association in children. Here, we report three children who underwent LT who required a concomitant or sequential gastrectomy for different reasons. Read More