29,277 results match your criteria Eosinophilic Granuloma Histiocytosis X


Structural and Mass Spectrometric Imaging Analyses of Adhered Tunic and Adhesive Projections of Solitary Ascidians.

Zoolog Sci 2018 Dec;35(6):535-547

2 Natural Science Center for Basic Research and Development, Hiroshima University, 1-4-2 Kagamiyama, Higashi-hiroshima, Hiroshima 739-8521, Japan.

Most ascidian species settle on underwater substrates during a short free-swimming tadpole larval period. During this process, "rapid adhesion" occurs on adhesive papillae located at the anterior region of the cephalenteron. Settled and transformed ascidians subsequently expand the attachment area by "slow adhesion" with ampullae. Read More

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December 2018

Elevated expression of IL-17RB and ST2 on myeloid dendritic cells is associated with a Th2-skewed eosinophilic inflammation in nasal polyps.

Clin Transl Allergy 2018 29;8:50. Epub 2018 Nov 29.

1Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Road II, Guangzhou, 510080 Guangdong China.

Background: Interleukin(IL)-25, IL-33, and thymic stromal lymphopoietin (TSLP) underlie the crosstalk between epithelial cells and dendritic cells (DCs) during the development of Th2 responses. This study aimed to measure the expressions of IL-17RB, ST2 and TSLPR, receptor of IL-25, IL-33, and TSLP respectively, on myeloid DCs in nasal polyps (NP) and evaluate their association with local Th2 inflammation and disease severity in patients with NP.

Methods: Samples were collected from 30 NP patients and 16 control subjects recruited prospectively. Read More

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November 2018

Eosinophil Counts in Mucosal Biopsies of the Ileum and Colon: Interobserver Variance Affects Diagnostic Accuracy.

Patholog Res Int 2018 4;2018:2638258. Epub 2018 Nov 4.

Department of Gastroenterology and Hepatology, University Medical Center Brandenburg, Brandenburg, Germany.

Primary eosinophilic gastroenteritis and colitis (EGE) is a rare entity with unspecific clinical and endoscopic findings. Validated histopathologic criteria for confirming the diagnosis are lacking, because numeric values for normal or elevated concentrations of eosinophils in mucosal biopsies are varying between observers. To quantify this interobserver variance, we had the same set of 30 slides of eosinophilic-rich mucosal biopsies from the ileum and colon systematically reviewed by a panel of six independent pathologists, each with more than a ten-year experience in the field. Read More

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November 2018

Precision medicine in COPD: review of mepolizumab for eosinophilic COPD.

Breathe (Sheff) 2018 Dec;14(4):338-341

Bolton NHS Foundation Trust, Bolton, UK.

http://ow.ly/uklu30m4YcU. Read More

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December 2018

Correction: Synergistic activation of pro-inflammatory type-2 CD8  T lymphocytes by lipid mediators in severe eosinophilic asthma.

Mucosal Immunol 2018 Dec 5. Epub 2018 Dec 5.

Respiratory Medicine Unit and Oxford Biomedical Research Centre, Nuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.

This article was originally published under standard licence, but has now been made available under a [CC BY 4.0] license. The PDF and HTML versions of the paper have been modified accordingly. Read More

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December 2018
1 Read

The role of surfactant protein-A in sinusitis.

Authors:
Eugene H Chang

Curr Opin Allergy Clin Immunol 2018 Nov 29. Epub 2018 Nov 29.

Department of Otolaryngology - Head & Neck Surgery, University of Arizona College of Medicine, Tucson, Arizona, USA.

Purpose Of Review: Surfactant protein-A (SP-A) is a collectin protein expressed in airway epithelia that is critical in the modulation of both innate and adaptive immunity against inhaled pathogens. In this review, we highlight associations of altered SP-A function in asthma and chronic rhinosinusitis, and its potential role as a targeted therapy for sinusitis.

Recent Findings: SP-A has been shown to bind and opsonize inhaled pathogens, thereby clearing bacteria through phagocytosis. Read More

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November 2018

Group 2 innate lymphoid cells and eosinophilic chronic rhinosinusitis.

Curr Opin Allergy Clin Immunol 2018 Nov 29. Epub 2018 Nov 29.

Department of Otorhinolaryngology, Shiga University of Medical Science, Otsu, Japan.

Purpose Of Review: Chronic rhinosinusitis (CRS) is a heterogeneous disease and is recently classified into two phenotypes, eosinophilic CRS (ECRS) and non-ECRS. ECRS is characterized by Th2-biased eosinophilic inflammation, and non-ECRS is characterized by Th1-biased neutrophilic inflammation. Group 2 innate lymphoid cells (ILC2s) rapidly produce large amounts of Th2 cytokines and exert critical roles in Th2-type immune responses. Read More

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November 2018

Methodological Concerns of a Recent Network Meta-analysis Assessing Biologics for Eosinophilic Asthma.

Lung 2018 Nov 30. Epub 2018 Nov 30.

Value Evidence and Outcomes, GlaxoSmithKline, Upper Providence, USA.

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November 2018

Current understanding of allergic fungal rhinosinusitis.

World J Otorhinolaryngol Head Neck Surg 2018 Sep 9;4(3):179-185. Epub 2018 Nov 9.

McGovern Medical School at the University of Texas Health Science Center, Department of Otorhinolaryngology-Head & Neck Surgery, Houston, TX 77030, USA.

Studying the pathophysiology of allergic fungal rhinosinusitis (AFRS) has proved challenging. While this clinical entity is easily distinguishable based on the clinical criteria set forth by Bent and Kuhn twenty-five years ago, studies examining type 2 inflammatory profiles in AFRS can make it seem more alike other CRS subtypes than it is different. Still, evolving research seems to clearly delineate this subtype from others in CRS. Read More

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September 2018
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A Rare Primary Tumor of the Thyroid Gland: A New Case of Leiomyoma and Literature Review.

Clin Med Insights Oncol 2018 26;12:1179554918813535. Epub 2018 Nov 26.

Department of Pathology, Wanbei Coal-Electricity Group General Hospital, Suzhou, China.

Primary leiomyomas of the thyroid are very rare. We here report a case of a 53-year-old woman with a painless mass at the right thyroid, revealed by physical examination. The patient underwent a lobectomy. Read More

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November 2018

A rare case of solitary unifocal Langerhans cell histiocytosis with orbital extension: Diagnostic dilemma.

Oman J Ophthalmol 2018 Sep-Dec;11(3):284-287

Department of Ophthalmology, University of Malaya Medical Centre, Kuala Lumpur, Malaysia.

Langerhans cell histiocytosis (LCH) is rarely encountered in ophthalmology practice. It is a spectrum of disorder characterized by accumulation of histiocytes in various tissues. Diagnosis is challenging as it may simulate periorbital hematoma, rhabdomyosarcoma, and neuroblastoma. Read More

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December 2018

Differential diagnosis of idiopathic inflammatory myopathies in adults - the first step when approaching a patient with muscle weakness.

Reumatologia 2018 31;56(5):307-315. Epub 2018 Oct 31.

Department of Systemic Connective Tissue Diseases, National Institute of Geriatrics, Rheumatology, and Rehabilitation, Warsaw, Poland.

Despite its misleading adjective, the most commonly used diagnostic criteria of idiopathic inflammatory myopathies (IIM) are applicable only after all other non-autoimmune muscle diseases have been excluded. It makes differential diagnosis the first step when approaching a patient with muscle weakness. This article is designed to list the most common conditions from which to differentiate in rheumatological care. Read More

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October 2018

Hypereosinophilic syndrome: approach to treatment in the era of precision medicine.

Authors:
Amy Klion

Hematology Am Soc Hematol Educ Program 2018 Nov;2018(1):326-331

Human Eosinophil Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.

Hypereosinophilic syndromes (HESs) are a heterogeneous group of rare disorders characterized by peripheral eosinophilia and eosinophilic end organ complications. Conventional therapies, including glucocorticoids and cytotoxic and immunomodulatory agents, have variable efficacy and significant toxicity. Although the recent development of agents that target eosinophils, including tyrosine kinase inhibitors and monoclonal antibodies, provides the possibility of more effective, less toxic approaches to treatment of HES, there are little available data to guide their use in these conditions. Read More

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November 2018

Clinical features at baseline do not predict symptomatic placebo response in patients with eosinophilic esophagitis.

Clin Gastroenterol Hepatol 2018 Nov 28. Epub 2018 Nov 28.

Division of Gastroenterology, Mayo Clinic, Rochester, MN, USA.

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November 2018

Innate lymphoid cells in asthma: pathophysiological insights from murine models to human asthma phenotypes.

Curr Opin Allergy Clin Immunol 2018 Dec 3. Epub 2018 Dec 3.

Department of Microbiology and Immunology, Laboratory of Clinical Immunology, KU Leuven, Leuven, Belgium.

Purpose Of Review: The current review describes the role of different types of innate lymphoid cells (ILCs) in the pathogenesis of asthma inflammatory phenotypes by linking findings from murine asthma models with human studies. Novel treatment options are needed for patients with steroid-insensitive asthma. Strategies targeting ILCs, or their upstream or downstream molecules are emerging and discussed in this review. Read More

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December 2018

Diagnosis of a case of ligneous gingivitis in a patient with moderate plasminogen deficiency.

J Stomatol Oral Maxillofac Surg 2018 Dec 1. Epub 2018 Dec 1.

Service d'Odontologie du CHU, 549 avenue du Pr JL Viala, 34295 Montpellier cedex 5, France. Electronic address:

Plasminogen deficiency is a rare congenital condition that leads to pseudomembraneous lesions, such as ligneous conjunctivitis and ligneous gingivitis. Because of its rarity, ligneous gingivitis is not a pathology one may easily suspect from its clinical symptoms. We report the case of a 35-year-old Caucasian woman who experienced gum masses with white spots, but no pain. Read More

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December 2018
2 Reads

A Spontaneous Regression of an Isolated Lymph Node Metastasis from a Primary Unknown Merkel Cell Carcinoma in a Patient with an Idiopathic Hyper-Eosinophilic Syndrome.

Am J Case Rep 2018 Dec 4;19:1437-1440. Epub 2018 Dec 4.

Division of Medical Oncology, Centre Hospitalier Régional (CHR) Metz-Thionville, Ars-Laquenexy, France.

BACKGROUND Merkel cell carcinoma (MCC) is a rare, aggressive primary cutaneous neuroendocrine tumor frequently associated with Merkel cell polyomavirus infection. Despite its aggressiveness, a few reports of spontaneous MCC regression have been described in the literature, most of them following incisional biopsy supporting a hypothetical role of surgery-induced inflammation in the process of regression. CASE REPORT We report a case of 69-year-old Caucasian male who was followed for an idiopathic hyper-eosinophilic syndrome. Read More

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December 2018

Eosinophilic asthma, according to a blood eosinophil criterion, is associated with disease severity and lack of control among underprivileged urban Brazilians.

Respir Med 2018 Dec 23;145:95-100. Epub 2018 Oct 23.

ProAR, Núcleo de Excelência Em Asma, Universidade Federal da Bahia, Brazil. Electronic address:

Background: Asthma is a syndrome with multiple phenotypes. Peripheral blood eosinophil counts might be the ideal biomarker to identify subjects with eosinophilic asthma. It is available, inexpensive, and it is associated with eosinophilia in sputum. Read More

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December 2018

Placental Cytomegalovirus Infection.

Arch Pathol Lab Med 2018 Nov 30. Epub 2018 Nov 30.

From the Department of Pathology, University of Colorado, Anschutz Medical Campus, Aurora (Dr Lindholm); and the Department of Pathology, Denver Health Medical Center, Denver, Colorado (Dr O'Keefe).

In the United States, cytomegalovirus is the most common congenital viral infection and the number 1 cause of nonhereditary sensorineural hearing loss. The vast majority of infants may be asymptomatic, especially if cytomegalovirus is contracted later in the pregnancy, and some symptoms may have a delayed onset. Therefore, it is important for the pathologist to identify the common histologic findings to help confirm the diagnosis so the child can be followed for late sequelae. Read More

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November 2018
1 Read

Conjunctival Colloid Milium.

Cornea 2018 Nov 27. Epub 2018 Nov 27.

Department of Pathology, Vision Research Foundation, Sankara Nethralaya, Chennai, India.

Purpose: To describe a rare case of conjunctival colloid milium.

Methods: Case report.

Results: We report a 45-year-old woman with a history of a slow-growing, painless mass extending from the medial canthal region to the inferior fornix and the inferior bulbar conjunctiva associated with redness. Read More

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November 2018

How I investigate Eosinophilia.

Int J Lab Hematol 2018 Nov 30. Epub 2018 Nov 30.

Medical College of Georgia, Augusta University, Augusta, Georgia.

Eosinophilia is typically secondary, that is, reactive, in nature and is associated with a wide variety of neoplastic and non-neoplastic disorders. Clonal eosinophilia is also seen in a wide variety of hematopoietic neoplasms, and sub-classification can be diagnostically challenging. A proper evaluation of persistent eosinophilia involves correlation of clinical history, laboratory data, cellular morphology, and ancillary testing. Read More

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November 2018

Changes in the clinical and histological characteristics of Chinese chronic rhinosinusitis with nasal polyps over 11 years.

Int Forum Allergy Rhinol 2018 Nov 29. Epub 2018 Nov 29.

Department of Otolaryngology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

Background: Traditionally, it was believed that chronic rhinosinusitis with nasal polyps (CRSwNP) demonstrated less eosinophilic and more neutrophilic inflammation in China compared to North America and Europe. However, inflammatory patterns may change over time. The study aimed to analyze the changing trends in the clinical and histological characteristics of CRSwNP over time in China. Read More

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November 2018

Eosinophils Target Therapy for Severe Asthma: Critical Points.

Biomed Res Int 2018 25;2018:7582057. Epub 2018 Oct 25.

Department of Medical Science, University of Torino, Italy.

Asthma is a chronic and heterogeneous disease, which is defined as severe disease whenever it requires treatment with a high dose of inhaled corticosteroids plus a second controller and/or systemic corticosteroids to prevent it from becoming ''uncontrolled" or if it remains ''uncontrolled" despite this therapy. Severe asthma is a heterogeneous condition consisting of phenotypes such as eosinophilic asthma, which is characterized by sputum eosinophilia, associated with mild to moderate increase in blood eosinophil count, frequently adult-onset, and associated with chronic rhinosinusitis with nasal polyps in half of the cases. Eosinophilic asthma is driven by T2 inflammation, characterized, among the others, by interleukin-5 production. Read More

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October 2018

A rare case report of polyangiitis overlap syndrome: granulomatosis with polyangiitis and eosinophilic granulomatosis with polyangiitis.

BMC Pulm Med 2018 Nov 29;18(1):181. Epub 2018 Nov 29.

Department of Pulmonary, Critical Care, Hyperbaric and Sleep Medicine, Loma Linda University Medical Center, 11234 Anderson St., Loma Linda, CA, 92354, USA.

Background: Granulomatosis with polyangiitis (GPA) is a systemic ANCA-associated vasculitis characterized by necrotizing granulomatous inflammation and a predilection for the upper and lower respiratory tract. Eosinophilic granulomatosis with polyangiitis (EGPA) is also a systemic ANCA-associated vasculitis, but EGPA is characterized by eosinophilic as well as granulomatous inflammation and is more commonly associated with asthma and eosinophilia. Polyangiitis overlap syndrome is defined as systemic vasculitis that does not fit precisely into a single category of classical vasculitis classification and/or overlaps with more than one category. Read More

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November 2018
1 Read

Bile duct resection for eosinophilic cholangitis.

ANZ J Surg 2018 Nov 29. Epub 2018 Nov 29.

Hepato-Pancreato-Biliary and Transplantation Unit, Austin Health, The University of Melbourne, Melbourne, Victoria, Australia.

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November 2018

Heterogeneity of NSAID-Exacerbated Respiratory Disease: has the time come for subphenotyping?

Authors:
Marek L Kowalski

Curr Opin Pulm Med 2019 Jan;25(1):64-70

Department of Immunology and Allergy, Faculty of Medicine, Medical University of Łódź, Łódź, Poland.

Purpose Of Review: NSAID-Exacerbated Disease (N-ERD) is a chronic eosinophilic inflammatory disorder of the respiratory tract occurring in patients with asthma and/or rhinosinusitis with nasal polyps, whose symptoms are exacerbated by NSAIDs. The purpose of this review is to provide an update on clinical characteristics, pathophysiology, and management of N-ERD, and to emphasize heterogeneity of this syndrome.

Recent Findings: Growing evidence indicates that N-ERD, which has been considered a separate asthma phenotype, is heterogenous, and can be divided in several subphenotypes varying in clinical characteristics. Read More

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January 2019

Novel PLAG1 Gene Rearrangement Distinguishes a Subset of Uterine Myxoid Leiomyosarcoma From Other Uterine Myxoid Mesenchymal Tumors.

Am J Surg Pathol 2018 Nov 27. Epub 2018 Nov 27.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.

Genetic alterations in uterine myxoid leiomyosarcoma are unknown. We investigate the clinicopathologic features of 19 uterine tumors previously diagnosed as myxoid leiomyosarcomas in which tumoral RNA was subjected to targeted RNA sequencing. PLAG1, BCOR, BCORL1, HMGA2, and ALK break-apart fluorescence in situ hybridization (FISH) and BCOR, PLAG1, and ALK immunohistochemistry were performed in cases which failed or lacked fusions by sequencing. Read More

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November 2018

Association of upper and lower airway eosinophilic inflammation with response to omalizumab in patients with severe asthma.

J Asthma 2018 Nov 29:1-8. Epub 2018 Nov 29.

a Department of Respiratory Medicine and Infectious Diseases , Niigata University Graduate School of Medical and Dental Sciences , Niigata , Japan.

Background: The anti-immunoglobulin E monoclonal antibody, omalizumab, is used to treat severe asthma and has the potential to ameliorate airway inflammation. However, the effect of omalizumab in ameliorating upper airway inflammation has not been fully elucidated.

Objective: We investigated the association of upper and lower airway inflammation with the response to omalizumab treatment. Read More

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November 2018

Obesity-induced reduction of adipose eosinophils is reversed with low-calorie dietary intervention.

Physiol Rep 2018 Nov;6(22):e13919

Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee.

While many studies have characterized the inflammatory disposition of adipose tissue (AT) during obesity, far fewer have dissected how such inflammation resolves during the process of physiological weight loss. In addition, new immune cells, such as the eosinophil, have been discovered as part of the AT immune cell repertoire. We have therefore characterized how AT eosinophils, associated eosinophilic inflammation, and remodeling processes, fluctuate during a dietary intervention in obese mice. Read More

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November 2018

Aging in Primary Systemic Vasculitis: Implications for Diagnosis, Clinical Manifestations, and Management.

Drugs Aging 2018 Nov 28. Epub 2018 Nov 28.

Rheumatology Department, Policlinico S. Matteo, Fondazione IRCCS, University of Pavia, Pavia, Italy.

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) usually affect adults and older populations. The well recognized clinical (i.e. Read More

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November 2018
1 Read

Systematic review of histological remission criteria in eosinophilic esophagitis.

JGH Open 2018 Aug 13;2(4):158-165. Epub 2018 Jun 13.

Allergy-Asthma-Immunology Clinic, Department of Pediatric and Adolescent Medicine Western Michigan University M.D. Homer Stryker School of Medicine Kalamazoo Michigan US.

Elemental diets, dietary elimination, and steroid therapies are the most common therapies in the clinical trials for eosinophilic esophagitis (EoE). Histological findings (usually reported as eosinophils per microscopic high-powered field [hpf]) remain the most common end-point used to define response. Yet, the threshold for defining "response" and "remission" are ill-defined among consensus guidelines and may vary from study to study. Read More

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August 2018
3 Reads

SDH-deficient renal cell carcinoma - clinical, pathologic and genetic correlates: a case report.

BMC Urol 2018 Nov 27;18(1):109. Epub 2018 Nov 27.

Division of Urology, Department of Surgery, Juravinski Cancer Centre, McMaster University, Hamilton, ON, Canada.

Background: Succinate dehydrogenase (SDH)- deficient renal cell carcinoma (RCC) is a newly identified rare subtype of RCC, having only gained acceptance from the World Health Organization in 2016. To the best of our knowledge, there are only 55 reported cases worldwide. Here, we report a new case of SDH-deficient RCC. Read More

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November 2018
3 Reads

Intratumoral Heterogeneity Accounts for Apparent Progression of Noninvasive Serous Tumors to Invasive Low-grade Serous Carcinoma: A Study of 30 Low-grade Serous Tumors of the Ovary in 18 Patients With Peritoneal Carcinomatosis.

Int J Gynecol Pathol 2018 Nov 21. Epub 2018 Nov 21.

Division of Molecular Genetics and Pathology, Office of In Vitro Diagnostics and Radiological Health, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, Maryland (J.D.S.) Departments of Pathology (J.S., R.V., R.J.K.) Gynecology and Obstetrics (R.V., R.J.K.), the Johns Hopkins University School of Medicine, Baltimore, Maryland Department of Pathology and Laboratory Medicine, Washington Hospital Center, Washington, District of Columbia (J.K.).

Noninvasive ovarian low-grade serous tumors [atypical proliferative serous tumor (APST)/serous borderline tumor] appear to progress to invasive low-grade serous carcinoma (LGSC) at a low but regular rate. The underlying biology of this phenomenon is unknown. We studied 18 patients with 30 ovarian tumors (12 bilateral), including APST, noninvasive LGSC and invasive LGSC, who also had low-grade serous carcinomatosis. Read More

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November 2018
1 Read

Eosinophilic colitis and colonic eosinophilia.

Curr Opin Gastroenterol 2019 Jan;35(1):42-50

Faculty of Health and Medicine, School of Medicine & Public Health, University of Newcastle, Callaghan, Australia.

Purpose Of Review: Eosinophilic colitis is a rare condition, with a prevalence rate in the USA of 2-3/100 000 persons (0.003%), but diagnosed in 0.1% of biopsies in those colonoscoped for diarrhoea. Read More

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January 2019
10 Reads

Effectiveness of benralizumab for allergic and eosinophilic predominant asthma following negative initial results with omalizumab.

Respirol Case Rep 2019 Jan 21;7(1):e00388. Epub 2018 Nov 21.

Department of Respiratory Medicine National Hospital Organization Okayama Medical Center Okayama City Okayama Japan.

A 64-year-old woman, who had presented with a 30-year history of refractory asthma, and been treated with anti-allergic drug therapy, inhaled corticosteroids, a long-acting beta-agonist, and a long-acting muscarinic antagonist. She had been characterized as an allergic, eosinophilic asthmatic. Although omalizumab was tried initially, it was found to be insufficient. Read More

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January 2019

Biomarkers for Recurrent Wheezing and Asthma in Preschool Children.

Allergy Asthma Immunol Res 2019 Jan;11(1):16-28

Asthma and Allergy Center, Inje University Sanggye Paik Hospital, Seoul, Korea.

Wheezing is one of the characteristic symptoms of asthma, but all preschool children with wheezing are not diagnosed with asthma. Preschool children are not cooperative enough to participate in spirometry and invasive tests. Thus, there is no conventional method to diagnose asthma in preschool children. Read More

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January 2019
2 Reads

Antileukotrienes improve naso-ocular symptoms and biomarkers in patients with NARES and asthma.

Laryngoscope 2018 Nov 26. Epub 2018 Nov 26.

Rhinology Unit & Smell Clinic, Department of Otorhinolaryngology, Hospital Clinic, IDIBAPS, Universitat de Barcelona, CIBERES Barcelona, Catalonia, Spain.

Objective: The aim of our study was to analyze the montelukast effectiveness in improving oculonasal symptoms, patient-reported outcomes (PROs), and eosinophilic biomarkers in patients with nonallergic rhinitis eosinophilic syndrome (NARES).

Methods: We enrolled prospectively 80 symptomatic patients treated with 10 mg once a day of montelukast in monotherapy for 2 months. All patients were investigated before and after treatment. Read More

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November 2018
1 Read

[Multiple ulcerated tracheobronchial mucosal lesions in the eosinophilic granulomatosis with polyangiitis].

Rev Pneumol Clin 2018 Nov 24. Epub 2018 Nov 24.

Service de pneumologie, CHL, Strassen, Luxembourg.

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November 2018

Tumor-associated eosinophilia.

Vopr Onkol 2016;62(4):394-400

The review provides information on current literature on structural and functional features of eosinophilic granulocytes and their role in the pathogenesis of cancer. There are examined data of clinical and experimental studies about an influence of hemic and tissue eosinophilia on the course and prognosis of malignant tumors. Molecular mechanisms of action of eosinophils in tumor pathology are discussed. Read More

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January 2016

Variation in Endoscopic Activity Assessment and Endoscopy Score Validation in Adults with Eosinophilic Esophagitis.

Clin Gastroenterol Hepatol 2018 Nov 23. Epub 2018 Nov 23.

Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.

Background & Aims: Eosinophilic esophagitis (EoE) is assessed endoscopically (endoscopic activity), based on grades of edema, rings, exudates, furrows, and strictures (EREFS). We examined variations in endoscopic assessments of severity, developed and validated 3 EREFS-based scoring systems, and assessed responsiveness of these systems using data from a randomized placebo-controlled trial of patients with EoE.

Methods: For the development set, 5 gastroenterologists reviewed EREFS findings from 266 adults with EoE and provided endoscopist global assessment scores (EndoGA, scale of 0 to 10); variation (ΔEndoGA) was assessed using linear regression. Read More

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November 2018
6 Reads

A radiolucent lesion presenting calcification histopathologically: a classical case of CEOT.

J Exp Ther Oncol 2018 Nov;12(4):317-322

Dept of Oral Medicine and Radiology, Post Graduate Institute Of Dental Sciences, Rohtak, Haryana, India.

Objective: The calcifying epithelial odontogenic tumor (CEOT) is a rare benign odontogenic neoplasm that accounts for approximately 1% of all odontogenic tumors. Histologically, it shows sheets of polyhedral epithelial cells with deep eosinophilic cytoplasm and prominent nuclei. Globules of amyloid like material among tumor cells which undergoes calcification are evident. Read More

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November 2018

Dermatitis caused by autochthonous Cercopithifilaria bainae from a dog in Florida, USA: clinical, histological and parasitological diagnosis and treatment.

Vet Dermatol 2018 Nov 25. Epub 2018 Nov 25.

Department of Comparative, Diagnostic and Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, FL, 32610, USA.

Background: Cercopithifilaria bainae is a tick-vectored filarioid nematode associated with erythematous dermatitis in dogs. It has not been reported previously in the United States.

Hypothesis/objective: To describe clinical, histological and parasitological diagnosis and treatment of C. Read More

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November 2018

The dysphagia stress test for rapid assessment of swallowing difficulties in esophageal conditions.

Neurogastroenterol Motil 2018 Nov 25:e13512. Epub 2018 Nov 25.

Division of Gastroenterology & Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Background: Esophageal dysphagia is a common symptom in gastroenterology practice. Current rapid assessment tools are limited to oropharyngeal dysphagia and do not translate well to esophageal conditions. We aim to create a novel tool, the dysphagia stress test (DST), to evaluate swallowing in patients with esophageal disease characterized by dysphagia. Read More

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November 2018
3 Reads

Interleukin-18 has an Important Role in Differentiation and Maturation of Mucosal Mast Cells.

J Mucosal Immunol Res 2018 2;2(1). Epub 2018 Jul 2.

Department of Medicine, Tulane Eosinophilic Disorders Center, Tulane University School of Medicine, New Orleans, USA.

A significant amount of correlational evidence has linked increased levels of IL-18 with allergic diseases in both human and animal models, and, as mast cells are major mediators of allergies, we hypothesized that IL-18 may have a role in mast cell biology. Rationale for our hypothesis is based on the evidence that IL-3 deficient mice are not devoid of mast cells, even though IL-3 is a major differentiation and growth factor for mast cells. Accordingly, we cultured IL-18 responsive bone marrow CD34+ cells under a variety of conditions and cytokine combinations to examine mast cell differentiation and maturation using flow cytometry, quantitative PCR,and immunostaining techniques. Read More

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Case Report of Atypical Juxtaglomerular Cell Tumor.

Case Rep Pathol 2018 24;2018:6407360. Epub 2018 Oct 24.

Department of Urology, Sakai City Hospital Organization, Sakai City Medical Center, Sakai, Japan.

Juxtaglomerular cell tumor (JGCT) is a rare renal tumor, producing renin and behaving almost in a benign fashion. So far, only three cases have been reported as malignant. We report a rare case with atypical JGCT. Read More

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October 2018
3 Reads

Airway innate lymphoid cells in the induction and regulation of allergy.

Allergol Int 2018 Nov 22. Epub 2018 Nov 22.

Department of Medicine, University of California, San Diego, CA, USA. Electronic address:

The recent discovery of innate lymphoid cells has revolutionized our understanding of the pathogenesis of immune diseases including allergy and asthma. Innate lymphoid cells (ILCs) are a heterogeneous collection of lymphocytes that lack antigen-specificity (non-T, non-B cells) and potently produce characteristic cytokines of T cell subsets (Th1, Th2, Th17). ILCs are divided into group 1 (ILC1s), group 2 (ILC2s), or group 3 (ILC3s). Read More

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November 2018