3,255 results match your criteria Eosinophilic Granuloma Histiocytosis X


Langerhans Cell Histiocyosis In The Oral And Maxillofacial Region: An Update.

J Oral Pathol Med 2021 Jun 5. Epub 2021 Jun 5.

Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.

Langerhans cell histiocytosis (LCH) is a rare disorder characterized by abnormal proliferation and infiltration of histiocytic cells. It can involve single or multiple organs and systems, with bone and skin being the most commonly affected sites. Regarding skeletal manifestations, the jawbones are involved in about 20% to 30% of all cases. Read More

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Recurrent eosinophilic granuloma involving maxilla and mandible in an adult male: An unusual case report.

Aust Dent J 2021 May 27. Epub 2021 May 27.

State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, China.

Langerhans cell histiocytosis (LCH) is a disease spectrum characterized by the intense infiltration/accumulation of Langerhans' cells in the affected tissues. Eosinophilic granuloma is the mildest form of LCH which mainly affects the skull, mandible, ribs and femur in children and young adults but rarely occurs in the maxilla. Here, we describe an unusual case of Eosinophilic granuloma affecting the tissues adjacent to tooth #25 and tooth #46 (FDI numbering system) in a 35-year-old male. Read More

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Multifocal eosinophilic granuloma of the jaws with long-term follow-up: a case report.

Hua Xi Kou Qiang Yi Xue Za Zhi 2021 Jun;39(3):355-361

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.

Eosinophilic granuloma, a rare disease, has various clinical manifestations and no specific X-rays features and is thus easily misdiagnosed. This paper reports a case of multifocal eosinophilic granuloma of jaw with long-term follow-up. The patient initially presented with periodontal tissue destruction. Read More

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Multisystem Langerhans Cell Histiocytosis in an infant.

Radiol Case Rep 2021 Jul 6;16(7):1798-1805. Epub 2021 May 6.

Department of Radiology, Madigan Army Medical Center, 9040A Jackson Ave, Joint Base Lewis-McChord, WA 98431, USA.

Langerhans cell histiocytosis (LCH) is a rare enigmatic disease that pre-dominantly affects children under 5 years of age. We report an interesting case of a 5 month old female diagnosed with multisystem LCH. Her disease process included osseous, pulmonary, gastrointestinal, cutaneous, hematopoietic and neurologic involvement. Read More

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Otologic Manifestations of Langerhans Cell Histiocytosis: A Systematic Review.

Otolaryngol Head Neck Surg 2021 May 4:1945998211004590. Epub 2021 May 4.

Hackensack University Medical Center, Hackensack, New Jersey, USA.

Objective: To perform a systematic review to investigate common otologic manifestations of Langerhans cell histiocytosis, the incidence of these findings, methods for diagnosis, as well as medical and surgical management.

Data Sources: PubMed/MEDLINE, Embase, and Cochrane Library.

Review Methods: A search of PubMed/MEDLINE, Embase, and Cochrane Library for all articles published between 1963 to 2020 was performed with variations and combinations of the following search terms: Langerhans cell histiocytosis, eosinophilic granuloma, Letterer-Siwe, Hand-Schüller-Christian, otitis, otologic, ear. Read More

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Eosinophilic granuloma of cranial location: report of a case and bibliographic review

Rev Fac Cien Med Univ Nac Cordoba 2021 03 12;78(1):48-51. Epub 2021 Mar 12.

Hospital Clinico Universitario Lozano Blesa. Zaragoza. España.

Introduction: Eosinophilic granuloma is an unusual benign disease that usually affects the pediatric population and young adults. It is the most benign of the diseases traditionally known as histiocytosis X that are now called Langerhans cell histiocytosis.

Clinical Case: Pediatric patient with a painful lump in the temporal region. Read More

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Role of Stereotactic Radiosurgery in Intracranial Histiocytosis: a Systematic Review of Literature of an Emerging Modality for Localized Disease.

World Neurosurg 2021 Jun 17;150:64-70. Epub 2021 Mar 17.

Department of Radiation Therapy, Postgraduate Institute of Medical Education and Research, Chandigarh. Electronic address:

Background: A histiocytosis is a group of immunoproliferative disorders of clonal cells. The management protocols are still evolving, with chemotherapy as the mainstay of treatment.

Objective: This study aims to evaluate the feasibility, safety, efficacy, and complication profile of stereotactic radiosurgery for intracranial histiocytosis. Read More

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Multifocal Langerhans Cell Histiocytosis: A Unique Presentation of Eosinophilic Granuloma with Intracranial Extension, Massive Lymphadenopathy, and Epstein-Barr Viral Infection in an Adolescent Female.

Case Rep Dermatol 2021 Jan-Apr;13(1):28-35. Epub 2021 Jan 25.

Division of Dermatology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, USA.

We report the case of an otherwise healthy 17-year-old female who presented for surgical removal of an enlarging "atypical cyst" on her scalp. During subtotal excision, only friable serosanguinous translucent ribbons of tissue were found. A histopathologic diagnosis of Langerhans cell histiocytosis (LCH) was rendered and imaging studies revealed extradural invasion of the tumor. Read More

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January 2021

Unisystem Langerhans cell histiocytosis in maxillofacial region in pediatrics: comprehensive and systematic review.

Oral Maxillofac Surg 2021 Feb 16. Epub 2021 Feb 16.

Department of Dentistry, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

Background: The study aimed to identify, enlist, and analyze cases of unisystem LCH in the maxillofacial pediatric population to understand the clinical presentation and encourage the consideration of this rare disease in the differential diagnosis. Langerhans cell histiocytosis (LCH) is an aggressive benign condition affecting mainly the pediatric population. It can be easily masked as periodontal disease in the maxillofacial region. Read More

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February 2021

Solitary tibial lesion as the initial presentation of Langerhans cell histiocytosis: report of two cases and literature review.

J Int Med Res 2021 Jan;49(1):300060520982826

Department of Orthopaedic Surgery, National Taiwan University Hospital, Taipei, Taiwan.

The various presentations of osseous Langerhans cell histiocytosis (LCH) make it difficult to distinguish from other bone diseases. In addition, there is no universally accepted protocol for managing osseous LCH for single non-central nervous system-risk lesions. Here, the rare cases of two paediatric patients, aged 1 and 2 years, who presented with a solitary tibial lesion at time of LCH diagnosis, are reported. Read More

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January 2021

Histiocytosis in the pediatric spine: a clinical and radiographic analysis of 50 patients.

Spine Deform 2021 May 5;9(3):823-831. Epub 2021 Jan 5.

Servicio de Patología Espinal, Hospital de Pediatría Prof. Dr. Juan P. Garrahan, Combate de los Pozos 1881, C1245AAM, Buenos Aires, CABA, Argentina.

Study Design: Descriptive, retrospective. Scientific level of evidence IV.

Objectives: The aim of this study was to evaluate a consecutive case series of 50 pediatric patients with LCH of the spine. Read More

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Eosinophilic Granuloma of the Skull Presenting as Non-Traumatic Extradural Haematoma in Children.

Int J Gen Med 2020 24;13:1229-1234. Epub 2020 Nov 24.

Neurosciences Research Centre, Molecular and Clinical Sciences Research Institute, St George's University of London, London, UK.

Cranial extradural haematoma (EDH) is a neurosurgical emergency that can be caused by traumatic or non-traumatic causes with the former being more prevalent. Non-traumatic causes are variable and can include infection, vascular malformation and haematological disorders. This paper will address an extremely rare non-traumatic cause of EDH. Read More

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November 2020

Eosinophilic Granuloma of the Mandible.

Ann Maxillofac Surg 2020 Jan-Jun;10(1):254-257. Epub 2020 Jun 8.

Department of Oral and Maxillofacial Surgery, Pushpagiri College of Dental Sciences, Thiruvalla, Kerala, India.

Eosinophilic granuloma (EG) is a rare histiocytic disorder resulting from clonal proliferation of Langerhans cells. Eosinophilic granuloma, the most benign of the three entities of Langerhans cell histiocytosis, may be multiple or solitary. This lesion can affect any bones but commonly involves the mandible when the jaws are affected. Read More

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Nasal polyps in eosinophilic granulomatosis with polyangiitis: Structured histopathology and CD105 expression.

Am J Otolaryngol 2020 Nov - Dec;41(6):102661. Epub 2020 Aug 10.

Department of Neuroscience - DNS, Otolaryngology Section, Padova University, Via Giustiniani 2, 35128 Padova, Italy. Electronic address:

Purpose: Distinguishing the prodromal nasal polyposis of eosinophilic granulomatosis with polyangiitis (EGPA) from chronic rhinosinusitis with nasal polyps (CRSwNP) is a challenge for rhinologists and rheumatologists. It has recently been reported that angiogenesis and CD105 expressed on vascular endothelial cells could have a role in the pathogenesis and development of nasal polyps. This exploratory study examined the structured histopathology of nasal polyps in patients with EGPA and CRSwNP, comparing CD105 expression in their nasal tissue with that of a control group with no chronic sinonasal inflammation. Read More

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December 2020

Vertebra Plana in Children May Result from Etiologies Other Than Eosinophilic Granuloma.

Clin Orthop Relat Res 2020 Oct;478(10):2367-2374

F. Baky, T. A. Milbrandt, C. Arndt, M. T. Houdek, A. N. Larson, Department of Orthopedic Surgery, Mayo Clinic, Rochester MN, USA.

Background: Vertebra plana in children is a diagnostic dilemma for orthopaedic surgeons. This radiographic finding sometimes has been said to be pathognomonic for eosinophilic granuloma (Langerhans cell histiocytosis); however, vertebra plana may also be caused by a range of other conditions. We sought to determine whether vertebra plana can be associated with malignancies other than eosinophilic granuloma. Read More

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October 2020

Eosinophilic Granulomatosis With Polyangiitis: An Unusual Case of Pediatric Subglottic Stenosis.

Laryngoscope 2021 03 20;131(3):656-659. Epub 2020 Jun 20.

Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, U.S.A.

Systemic disease is an uncommon cause of subglottic stenosis (SGS). We report a case of severe SGS due to underlying eosinophilic granulomatosis with polyangiitis (EGPA) in a child presenting with isolated stridor. EGPA is a rare systemic vasculitis with very limited cases reported in the pediatric population. Read More

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Long-term Follow-up of Eosinophilic Granulomas of the Axial and Appendicular Skeleton Managed With Biopsy Alone.

J Pediatr Orthop 2020 Nov/Dec;40(10):615-622

Department of Orthopaedics and Traumatology, Koc University Hospital, Istanbul, Turkey.

Background: This study aimed to evaluate the long-term clinical and radiologic follow-up results of eosinophilic granulomas (EGs) of the axial and appendicular skeleton managed with biopsy alone.

Methods: Fifty-five patients with unifocal osseous EGs of the axial and appendicular skeleton were followed after biopsy. Patients were divided into 2 groups on the basis of localization of the lesions. Read More

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Canine eosinophilic pulmonary granulomatosis: case report and literature review.

J Vet Diagn Invest 2020 Mar;32(2):329-335

Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada. Current address: Tudor Glen Veterinary Hospital, St. Albert, Alberta, Canada (Abbott).

We describe and illustrate herein a case of eosinophilic pulmonary granulomatosis (EPG) in a 16-mo-old, castrated male, Great Pyrenees crossbred dog. EPG appears to differ from eosinophilic pneumonias and eosinophilic bronchopneumopathy in dogs by the presence of nodules and masses in the lungs composed of eosinophils, macrophages, and various combinations of lymphocytes, plasma cells, neutrophils, and mast cells within fibrous tissue. Specific information from this dog was added to the information from the limited number of other dogs diagnosed with EPG reported in the veterinary literature, and the information analyzed. Read More

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Pulmonary Langerhans Cell Histiocytosis Associated with Bronchogenic Carcinoma.

Cureus 2020 Jan 12;12(1):e6634. Epub 2020 Jan 12.

Internal Medicine: Pulmonology/Critical Care, Charleston Area Medical Center, Charleston, USA.

Pulmonary Langerhans cell histiocytosis (PLCH, pulmonary eosinophilic granuloma) is a rare disease of clonal dendritic cells that primarily affects adults who smoke cigarettes. PLCH association with other malignancies is rarely reported. Herein, an unusual case of PLCH is presented with synchronous lung adenocarcinoma. Read More

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January 2020

Langerhans Cell Histiocytosis in an Adult with Oral Cavity Involvement: Posing a Diagnostic Challenge.

Contemp Clin Dent 2019 Jan-Mar;10(1):154-157

Department of Oral and Maxillofacial Pathology, Guru Nanak Institute of Dental Sciences and Research, Kolkata, West Bengal, India.

Langerhans cell histiocytosis (LCH) is a rare hematological disorder characterized by local or generalized, uncontrolled proliferation and infiltration of Langerhans type of histiocytic cells. It represents a spectrum of clinicopathologic disorders, ranging from a highly aggressive and frequently fatal multisystem disease to an easily cured solitary lesion of bone. Involvement of children and the younger age group is more common than the adults. Read More

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February 2020

A Case of Multi-System Langerhans Cell Histiocytosis with Local Invasion of the Orbital Apex.

Case Rep Ophthalmol 2019 Sep-Dec;10(3):319-326. Epub 2019 Sep 19.

Division of Ophthalmology, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.

Langerhans cell histiocytosis (LCH) is characterised by tissue destruction caused by the abnormal proliferation of pathogenic dendritic cells. We report a rare case of multi-system LCH with local invasion of the orbital apex. A 56-year-old woman suffered from a decrease of visual acuity in the left eye caused by central scotoma and the limitation of eye movement in all directions. Read More

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September 2019

Traumatic ulcerative granuloma with stromal eosinophilia - clinical case report, literature review, and differential diagnosis.

World J Surg Oncol 2019 Nov 9;17(1):184. Epub 2019 Nov 9.

Department of Oral and Craniomaxillofacial Surgery, University Hospital Basel, Spitalstrasse 21, CH-4031, Basel, Switzerland.

Background: Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is a rare self-limiting condition of the oral mucosa. The lesion manifests as an isolated ulcer that can be either asymptomatic or associated with mild to severe pain, and in most cases, it affects the tongue. TUGSE lesions may mimic malignancy such as squamous cell carcinoma, CD30 positive lymphoproliferative disorder, or infectious diseases such as primary syphilis, tuberculosis, or Epstein-Barr virus mucocutaneous ulcer. Read More

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November 2019

Outcome of Surgery as Sole Treatment of Eosinophilic Granuloma of Jaws.

J Dent (Shiraz) 2019 Sep;20(3):210-214

Dept. of Oral & Maxillofacial Surgery, School of Dentistry, Ardabil University of Medical Sciences, Ardabil, Iran.

Langerhans cell histiocytosis (LCH) is characterized by the congregation of proliferating langerhans cells (LC). Langerhans cells are a part of dendritic cell system of primary immune response that is responsible for presenting antigen to lymphocytes. Being a rare disease, the total incidence of LCH is reported to be 1 in 2 million people. Read More

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September 2019

Langerhans Cell Histiocytosis of the Skull.

Ear Nose Throat J 2021 May 26;100(4):219-221. Epub 2019 Sep 26.

Department of Otolaryngology, 12291Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA.

This is a case of a pediatric male who presented with a postauricular mass and pain. Computed tomography and magnetic resonance imaging suggested a diagnosis of Langerhans cell histiocytosis. Characteristic imaging findings and initial workup for Langerhans cell histiocytosis are described. Read More

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[Langerhans cell histiocytosis revealed by a temporomandibular joint disorder: Report of a case and review of the craniofacial expressions].

Rev Med Interne 2020 Jan 29;41(1):50-53. Epub 2019 Aug 29.

Service de chirurgie maxillo-faciale et stomatologie, centre hospitalo-universitaire de Rouen, 1, rue de Germont, 76000 Rouen, France; Laboratoire d'anatomie, faculté de médecine de Rouen, 22, boulevard Gambetta, 76000 Rouen, France; Institut national de la santé et de la recherche médicale (Inserm), LIMICS UMR-1142, 76000 Rouen, France. Electronic address:

Introduction: Langerhans cell histiocytosis (HL) is a rare disease that can affect all tissues. Oral manifestations such as mucosal ulcer and tooth mobility are often the first signs of the disease. We report a rare case of mandibular condyle unifocal HL mimicking a temporomandibular joint disorder. Read More

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January 2020

Eosinophilic bronchitis, eosinophilic granuloma, and eosinophilic bronchopneumopathy in 75 dogs (2006-2016).

J Vet Intern Med 2019 Sep 29;33(5):2217-2226. Epub 2019 Aug 29.

Department of Pathology, Microbiology and Immunology, The University of California School of Veterinary Medicine, Davis, California.

Background: Eosinophilic lung disease is a poorly understood inflammatory airway disease that results in substantial morbidity.

Objective: To describe clinical findings in dogs with eosinophilic lung disease defined on the basis of radiographic, bronchoscopic, and bronchoalveolar lavage fluid (BAL) analysis. Categories included eosinophilic bronchitis (EB), eosinophilic granuloma (EG), and eosinophilic bronchopneumopathy (EBP). Read More

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September 2019

Diagnosis and treatment of Langerhans Cell Histiocytosis with bone lesion in pediatric patient: A case report.

Ann Med Surg (Lond) 2019 Sep 2;45:102-109. Epub 2019 Aug 2.

Department of Orthopaedic and Traumatology, Dr.Cipto Mangunkusumo General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.

Background: Langerhans cell histiocytosis (LCH) is a rare group of disorders without a well understood etiology. Known formerly as histiocytosis X, the disease has a wide spectrum of clinical presentations, including eosinophilic granuloma (solitary bone lesion), diabetes insipidus, and exophthalmos. Many of these patients initially present to orthopaedic surgeons, and misdiagnosis is frequent. Read More

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September 2019

[Persistent diarrhea in a 77 year-old woman].

Rev Med Interne 2020 Feb 14;41(2):134-137. Epub 2019 Aug 14.

Service de médecine Interne de l'Agé, hôpitaux universitaires de Genève, faculté de médecine de Genève, Suisse.

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February 2020

Myopericarditis as a presentation of eosinophilic granulomatosus with polyangiitis (EGPA).

BMJ Case Rep 2019 Aug 15;12(8). Epub 2019 Aug 15.

Department of Cardiology, Aintree University Hospitals NHS Foundation Trust, Liverpool, UK.

A 60-year-old woman was admitted to the hospital with worsening dyspnoea, cough and chest pain. This was on a background of weight loss, decreased appetite, mononeuritis multiplex, chronic eosinophilia and a single episode of a non-blanching rash. Investigations demonstrated a raised troponin and ischaemic changes on ECG, and she was therefore initially treated for a presumed myocardial infarction. Read More

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