3,206 results match your criteria Eosinophilic Granuloma Histiocytosis X


Eosinophilic granuloma of the cervical spine in adults: A review.

World Neurosurg 2019 Feb 13. Epub 2019 Feb 13.

Department of Orthodontics, Manipal College of Dental Sciences, Manipal Academy of Higher education, Manipal, India.

Purpose: Spinal eosinophilic granulomas(EGs) are uncommon tumors, constituting <1% of all bone tumors. They are mostly seen in the pediatric age group while adult onset is rare. Cervical spine is an infrequent location for involvement by EG. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.230DOI Listing
February 2019

Eosinophilic Granuloma of Mandible: A Diagnostic Challenge.

Kathmandu Univ Med J (KUMJ) 2018 Apr-Jun;16(62):201-203

Department of Oral Surgery, Peoples Dental College, Shorakhutte, Kathmandu, Nepal.

Eosinophilic Granuloma is the mildest and localized form of Langerhans Cell Histiocytosis and is characterized by clonal proliferation of Langerhans cells. It is a rare disease, accounting for less than 1% of all the osseous neoplasms. It has predilection for the axial skeleton and incidence in jaws is just 7. Read More

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January 2019
1 Read

[Histiocitosis de Langerhans en el cráneo. Informe de un caso].

Cir Cir 2019 ;87(1):96-100

Delegación Baja California. Instituto Mexicano del Seguro Social, Baja California, México.

Background: Langerhans cell histiocytosis is a rare disease in the adult, predominates in the pediatric age and is more common in men than in women. The sites of greater affection are the long bones, followed by the bones of the skull. Patients usually have symptoms related to the site of affection, usually polyostotic lesions, monostotic lesions occur less frequently. Read More

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http://dx.doi.org/10.24875/CIRU.18000330DOI Listing
January 2019
2 Reads

Langerhans cell histiocytosis in adults is associated with a high prevalence of hematologic and solid malignancies.

Cancer Med 2019 Jan 30;8(1):58-66. Epub 2018 Dec 30.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.

Background: Langerhans cell histiocytosis (LCH) is a rare disorder of histiocyte proliferation. Previous case studies suggest a higher prevalence of hematologic and solid malignancies among LCH patients, possibly due to treatment with tumorigenic agents such as etoposide. We report the first large, single-institution experience of adult LCH patients with additional malignancies to study the characteristics of these patients. Read More

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http://dx.doi.org/10.1002/cam4.1844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346231PMC
January 2019
1 Read

Multidisciplinary rehabilitation of eosinophilic granuloma with bone graft surgery and a modified implant-supported hybrid prosthesis: A case report with a 6-year follow-up.

Spec Care Dentist 2019 Jan 15;39(1):45-50. Epub 2018 Nov 15.

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gazi University, Ankara, Turkey.

Eosinophilic granuloma is the most common form of Langerhans cell histiocytosis and corresponds with bone lesions characterized by pain, rapid growth, and high tendency of recurrence after inadequate curettage. It is a rare disease that is difficult to diagnose clinically and radiographically because it mimics other odontogenic cysts and tumors. In this report, the reconstruction of an osseous defect with an iliac graft and a modified implant-supported hybrid prosthesis after surgical excision of an eosinophilic granuloma in the mandible of a 27-year-old male patient was described. Read More

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http://dx.doi.org/10.1111/scd.12345DOI Listing
January 2019
11 Reads

[Histiocitosis de células de Langerhans con compromiso vertebral].

Bol Med Hosp Infant Mex 2018 ;75(5):309-312

Hospital San Rafael de Tunja, Boyacá. Colombia.

Introducción: La histiocitosis de células de Langerhans (HCL) es un trastorno histiocítico raro y su incidencia exacta se mantiene desconocida; se ha diagnosticado en todos los grupos de edad, pero es más común en los primeros 3 años de vida. Se caracteriza por lesiones únicas o múltiples de tipo osteolítico causadas por proliferación clonal de células histológicamente similares a las células de Langerhans; su presentación clínica es heterogénea.

Caso Clínico: Presentamos el caso de una paciente de sexo femenino de 7 años, con dificultad para la marcha y debilidad progresiva en los miembros inferiores de 5 días de evolución. Read More

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http://dx.doi.org/10.24875/BMHIM.M18000024DOI Listing
January 2018
4 Reads

[A case of multiple cerebral hemorrhage caused by sudden increase of eosinophil in a patient with eosinophilic granulomatosis with polyangiitis].

Rinsho Shinkeigaku 2018 Sep 31;58(9):565-569. Epub 2018 Aug 31.

Department of Neurology, Nagaoka Red Cross Hospital.

A 42-year-old woman with bronchial asthma was admitted to our hospital due to sensory dominant mononeuritis multiplex lasting for more than 6 months. At that time, her eosinophil count was 761/μl and her sural nerve biopsy showed no findings suggestive of vasculitis. Four months later, she experienced sudden convulsions and right hemiparesis due to left lobular parietal subcortical hemorrhage, when her eosinophil count was elevated to 3,257/μl. Read More

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http://dx.doi.org/10.5692/clinicalneurol.cn-001188DOI Listing
September 2018
3 Reads

An Unusual Presentation of Langerhans Cell Histiocytosis.

J Coll Physicians Surg Pak 2018 Sep;28(9):S172-S173

Department of Histopathology, Shifa International Hospital, Islamabad.

Langerhans cell histiocytosis (LCH) is a rare entity formerly known as eosinophilic granuloma. It is characterised by clonal multiplication of langerhans cells (LCs) that can occur anywhere in the body, especially in connective tissue of skin, lymph nodes and bone. Although rare, the disorder frequently affects children. Read More

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https://www.jcpsp.pk/data/view.php?id=356&type=pdf&j
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http://dx.doi.org/10.29271/jcpsp.2018.09.S172DOI Listing
September 2018
14 Reads

Langerhans cell histiocytosis of the orbit: A study of eight cases.

Oman J Ophthalmol 2018 May-Aug;11(2):134-139

Ocular Oncology Service, The Operation Eyesight Universal Institute for Eye Cancer, L V Prasad Eye Institute, Hyderabad, Telangana, India.

Background: Langerhans cell histiocytosis (LCH) of the orbit is a rare clinical entity with a diagnostic and therapeutic dilemma.

Materials And Methods: This was a retrospective study of eight patients with orbital LCH.

Results: All eight patients in our series were male, and the mean age at presentation was 8 years (median 6 years; range, 7 months-23 years). Read More

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http://dx.doi.org/10.4103/ojo.OJO_226_2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991070PMC
June 2018
20 Reads

Oral manifestation of Langerhans cell histiocytosis: a case report.

BMC Oral Health 2018 06 8;18(1):106. Epub 2018 Jun 8.

Clinic of Cranio-Maxillofacial and Oral Surgery, University of Zurich, University Hospital Zurich, Plattenstrasse 11, CH-8032, Zurich, Switzerland.

Background: Bone necrosis of the jaw is a serious condition with a broad differential diagnosis of pathologies such as cutaneous histiocytosis, bone metastases or malignant tumours. In addition to the most common cause, medication related osteonecrosis of the jaw (MRONJ), one must consider a number of other causes, such as histiocytosis. Langerhans cell histiocytosis (LCH) is a histiocytic disorder with a large spectrum of clinical manifestations and with possible involvement of a variety of organs. Read More

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http://dx.doi.org/10.1186/s12903-018-0568-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994067PMC
June 2018
4 Reads

Histiocytic lesions of the orbit: A study of 9 cases.

Saudi J Ophthalmol 2018 Jan-Mar;32(1):40-44. Epub 2018 Mar 15.

Department of Ophthalmology, Ankara University Faculty of Medicine, Ankara, Turkey.

Purpose: To describe the clinical presentation, treatment, and outcome of patients with histiocytic lesions of the orbit.

Methods: Retrospective study of 9 patients treated and followed up between October 2001 and January 2018.

Results: Eight patients in our series were males and one patient was female. Read More

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http://dx.doi.org/10.1016/j.sjopt.2018.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943821PMC
March 2018
3 Reads

F-FDG PET/CT for the Evaluation of Primary Eosinophilic Granuloma of the Hypothalamus.

J Nucl Med Technol 2018 Sep 3;46(3):290-291. Epub 2018 May 3.

Department of Medical Imaging, University of Arizona, Tucson, Arizona; and.

A 21-y-old man who presented with polyuria and polydipsia was discovered to have diabetes insipidus due to eosinophilic granuloma of the hypothalamus. F-FDG PET/CT, which was performed as a metastatic work-up, revealed an intensely F-FDG-avid hypothalamic mass and no other sites of disease. Read More

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http://dx.doi.org/10.2967/jnmt.118.209957DOI Listing
September 2018
5 Reads

A case report of orbital Langerhans cell histiocytosis presenting as a orbital cellulitis.

Arch Soc Esp Oftalmol 2018 Oct 8;93(10):503-506. Epub 2018 Apr 8.

Unidad de Órbita y Oculoplástica, Servicio de Oftalmología, Hospital Universitario de Gerona Dr. Josep Trueta, Gerona, España.

Clinical Case: A 10-year-old girl was seen with a 3-week history of right upper lid swelling and with no other symptoms or fever. There was no recent history of sinusitis, trauma, or previous infection involving the periorbital area, or response to oral antibiotic treatment. Orbital computed tomography showed a lesion involving the upper margin of the orbit, and bone destruction at the orbital roof. Read More

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http://dx.doi.org/10.1016/j.oftal.2018.03.003DOI Listing
October 2018
5 Reads

[Langerhans cell histiocytosis with orbital involvement in an infant: Case report].

Arch Argent Pediatr 2018 Apr;116(2):e283-e287

Hospital Nacional Edgardo Rebagliati Martins, Departamento de Anatomía Patológica.

The Langerhans cell histiocytosis is a rare disease characterized by the clonal proliferation of CD1a + myeloid dendritic cells associated with a significant inflammatory component. The localized form of the disease is called eosinophilic granuloma. Bone involvement is common; in children, lytic lesions are most frequently found in the cranial dome being rare in the orbit. Read More

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http://dx.doi.org/10.5546/aap.2018.eng.e283DOI Listing
April 2018
2 Reads

Multidisciplinary approach in a case of Hand-Schüller-Christian disease with maxillary involvement.

Spec Care Dentist 2018 Mar 8;38(2):107-111. Epub 2018 Feb 8.

Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.

Langerhans cell histiocytosis (LCH) is a childhood pathology with a peak of incidence ranging from 1 to 4 years of age, though diagnosis is often made in adult age. LCH is clinically classified into three types: eosinophilic granuloma, Hand-Schuller-Christian disease and Abt-Letterer-Siwe disease. We report a case of Hand-Schüller-Christian disease with diabetes insipidus, skull and maxillary involvement in a 16-year-old boy referred to our observation for gradual increase in mobility of the teeth and subsequent gradual loss of the second premolars and the first molars of the upper jaw. Read More

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http://dx.doi.org/10.1111/scd.12273DOI Listing
March 2018
3 Reads

Abdominal Angiostrongyliasis: A Presentation of Eosinophilic Granulomatous Colitis.

Int J Surg Pathol 2018 Aug 26;26(5):475-478. Epub 2017 Dec 26.

1 University of Texas Southwestern Medical Center, Dallas, TX, USA.

We present a case of a 4-year-old girl with abdominal angiostrongyliasis who presented with persistent fevers, hepatosplenomegaly, acute abdominal pain, and eosinophilia. Computed tomography scan identified thickening of the ascending colon with a narrowed lumen. Endoscopic evaluation revealed ulcerations and erythema in the ascending colon. Read More

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http://dx.doi.org/10.1177/1066896917749929DOI Listing
August 2018
9 Reads

Mixed histiocytosis: A case report and published work review.

J Dermatol 2018 Apr 15;45(4):491-495. Epub 2017 Dec 15.

Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, China.

Histiocytoses are a group of heterogeneous diseases that encompass Langerhans cell histiocytosis and non-Langerhans cell histiocytosis. Cutaneous plane xanthoma is a non-Langerhans cell histiocytic disorder characterized by the presence of yellow-orange plaques on the face, neck, upper trunk and extremities. It can appear in association with several systemic diseases (including dyslipidemias, paraproteinemias, cardiovascular diseases and lymphoproliferative disorders), but is rarely connected with Langerhans cell histiocytoses. Read More

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http://dx.doi.org/10.1111/1346-8138.14179DOI Listing
April 2018
10 Reads

Eosinophiler Granulozyt – manchmal Freund, manchmal Feind.

Authors:
Alex Straumann

Ther Umsch 2017 Nov;74(6):289

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http://dx.doi.org/10.1024/0040-5930/a000916DOI Listing
November 2017
4 Reads

Intradural Eosinophilic Granuloma Invading Skull: Case Report and Review of the Literature.

Asian J Neurosurg 2017 Oct-Dec;12(4):698-700

Department of Pathology, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India.

Eosinophilic granuloma is a localized form of Langerhans cell histiocytosis, most commonly involving the skeletal system. Their origin from the dura is rare with only a handful of cases on record. We present one such rare case of an eosinophilic granuloma originating from the dura mater with secondary osseous invasion in an 11-year-old female child who presented with a swelling in the right parietal region. Read More

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http://dx.doi.org/10.4103/ajns.AJNS_47_15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652098PMC
November 2017
12 Reads

An unusual gastric tumour with gastric outlet obstruction.

Gut 2018 09 28;67(9):1645-1646. Epub 2017 Sep 28.

Department of Internal Medicine, E-Da Hospital/I-Shou University, Kaohsiung, Taiwan.

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http://dx.doi.org/10.1136/gutjnl-2017-315087DOI Listing
September 2018
4 Reads

Traumatic ulcerative granuloma with stromal eosinophilia: a malignant-appearing benign lesion.

Cutis 2017 Aug;100(2):E28-E31

Wilford Hall Ambulatory Surgical Center, San Antonio Uniformed Services Health Education Consortium, Texas, USA.

Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is an underreported diagnosis in dermatologic literature. Rapid expansion with an ulcerative clinical appearance often provokes fear of malignancy despite its benign nature. Traumatic ulcerative granuloma with stromal eosinophilia is thought to be a reactive tissue response to trauma, but CD30 mononuclear cells within a TUGSE lesion suggests the possibility of an underlying lymphoproliferative disorder. Read More

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August 2017
25 Reads

Langerhans' cell histiocytosis with neurological injuries diagnosed from a single cutaneous lesion.

An Bras Dermatol 2017 Jul-Aug;92(4):540-542

Dermatology Service, Hospital Regional de Presidente Prudente, Presidente Prudente, SP, Brazil.

Histiocytoses are rare diseases caused by the proliferation of histiocytes. The pathogenesis remains unknown and the highest incidence occurs in pediatric patients. The clinical presentations can be varied, in multiple organs and systems, and the skin lesions are not always present. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20174743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595605PMC
October 2017
16 Reads

Atlanto-axial langerhans cell histiocytosis in a child presented as torticollis.

World J Clin Cases 2017 Aug;5(8):344-348

Miniar Tfifha, Saoussen Abroug, Pediatrics Department, Sahloul University Hospital, Sousse 4054, Tunisia.

Langerhans cell histiocytosis (LCH) is a rare condition mostly seen in children and adolescents. Eosinophilic granuloma (EG) is one of its three clinical entities and is considered as a benign osteolytic lesion. Many reports of patients with spine histiocytosis are well documented in the literature but it is not the case of atlantoaxial localization. Read More

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http://dx.doi.org/10.12998/wjcc.v5.i8.344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561504PMC
August 2017
15 Reads

Differential diagnosis of granulomatous lung disease: clues and pitfalls: Number 4 in the Series "Pathology for the clinician" Edited by Peter Dorfmüller and Alberto Cavazza.

Eur Respir Rev 2017 Sep 9;26(145). Epub 2017 Aug 9.

Interstitial and Rare Lung Disease Unit, Ruhrlandklinik, University of Duisburg-Essen, Essen, Germany

Granulomatous lung diseases are a heterogeneous group of disorders that have a wide spectrum of pathologies with variable clinical manifestations and outcomes. Precise clinical evaluation, laboratory testing, pulmonary function testing, radiological imaging including high-resolution computed tomography and often histopathological assessment contribute to make a confident diagnosis of granulomatous lung diseases. Differential diagnosis is challenging, and includes both infectious (mycobacteria and fungi) and noninfectious lung diseases (sarcoidosis, necrotising sarcoid granulomatosis, hypersensitivity pneumonitis, hot tub lung, berylliosis, granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis, rheumatoid nodules, talc granulomatosis, Langerhans cell histiocytosis and bronchocentric granulomatosis). Read More

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http://dx.doi.org/10.1183/16000617.0012-2017DOI Listing
September 2017
7 Reads

[Eosinophilic granuloma of the parietal bone of an adult patient with BRAF mutation].

Arkh Patol 2017;79(4):33-39

Academician B.V. Petrovsky Russian Research Center of Surgery, Moscow, Russia.

The paper describes a case of eosinophilic granuloma of the parietal bone in a 32-year-old man. Histological examination revealed a large number of bean-shaped Langerhans cell histiocytes with lobed nuclei and nuclear grooves. The histiocytes alternated with the foci of obvious eosinophilic infiltration and with eosinophilic microabscesses. Read More

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http://dx.doi.org/10.17116/patol201779433-39DOI Listing
April 2018
17 Reads

All That Wheezes….

N Engl J Med 2017 08;377(5):477-484

From the Departments of Medicine and Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston.

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http://dx.doi.org/10.1056/NEJMcps1607526DOI Listing
August 2017
16 Reads

All That Wheezes...

N Engl J Med 2017 07;377(4):e6

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http://dx.doi.org/10.1056/NEJMimc1613182DOI Listing
July 2017
13 Reads

A reply to the letter to the editor by Nima Derakhshan and Mahsa Roshanfarzad with regard to the paper "Pandora's box: eosinophilic granuloma at the cerebellopontine angle-should we open it?"

Childs Nerv Syst 2017 09 17;33(9):1427. Epub 2017 Jul 17.

Department of Neurosurgery, Antalya Atatürk State Hospital, Gençlik Mah. Fevzi Çakmak Cad. 3. Mahmut Çil Apart. No: 77/7, Muratpaşa, Antalya, Turkey.

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http://dx.doi.org/10.1007/s00381-017-3533-8DOI Listing
September 2017
2 Reads

Eosinophilic granuloma at the cerebellopontine angle in an adult; a rare case report and literature review.

Int J Surg Case Rep 2017 29;37:183-185. Epub 2017 Jun 29.

Pathology Department, Shiraz University of Medical Sciences, Shiraz, Iran.

Introduction: Langerhans cell histiocytosis (LCH) is a rare immunologic disorder, identified by immature proliferation of histiocytes which may present as systemic or focal lesions. Eosinophilic granuloma (EG) is localized from of LCH mainly involving bones such as skull, femur, spine, ribs, mandible and pelvis. Cerebello-pontine (CP) angle is a rare anatomic location for involvement by EG. Read More

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http://dx.doi.org/10.1016/j.ijscr.2017.06.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508616PMC
June 2017
9 Reads

Pediatric Langerhans cell histiocytosis of the lateral skull base.

Int J Pediatr Otorhinolaryngol 2017 Aug 15;99:135-140. Epub 2017 Jun 15.

Department of Otolaryngology - Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address:

Objective: Describe the presentation, imaging characteristics, management, and outcomes of pediatric patients with Langerhans cell histiocytosis (LCH) of the temporal bone.

Methods: A retrospective chart review was performed between 2000 and 2014 at a single tertiary care children's hospital. Fourteen patients were identified with a diagnosis of LCH and involvement of the temporal bone. Read More

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http://dx.doi.org/10.1016/j.ijporl.2017.06.011DOI Listing
August 2017
22 Reads

Cerebello-pontine angle eosinophilic granuloma; a reappraisal in the management of intracranial eosinophilic granuloma.

Childs Nerv Syst 2017 09 23;33(9):1425-1426. Epub 2017 Jun 23.

Student research committee, Neurosurgery Department, Shiraz University of Medical Sciences, 71937-11351, Namazi Square, Zand Street, Shiraz, Iran.

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http://dx.doi.org/10.1007/s00381-017-3495-xDOI Listing
September 2017
3 Reads

The outcome of eosinophilic granuloma involving unilateral atlantoaxial joint: A case report and literature review.

Medicine (Baltimore) 2017 Jun;96(25):e7197

aDepartment of Orthopedics, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei bDepartment of Ophthalmology, Shengjing Hospital of China Medical University, Shenyang, Liaoning cDepartment of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Rationale: Solitary eosinophilic granuloma (EG), the most benign, common form of Langerhans cell histiocytosis, has a self-limiting process and is associated with a good prognosis. Immobilization is recommended as the first treatment strategy for solitary EG, although the treatment protocols are still controversial. Radiotherapy and surgery are secondary treatment choices. Read More

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http://dx.doi.org/10.1097/MD.0000000000007197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5484214PMC
June 2017
35 Reads

[A lumbar vertebral eosinophilic granuloma with spinal instability in an adolescent].

Arch Pediatr 2017 Jul 3;24(7):618-621. Epub 2017 Jun 3.

Service de chirurgie pédiatrique, CHU Réunion, site Saint-Pierre, avenue Francois-Miterrand, 97410 Saint-Pierre, Réunion.

This is a case report of a rare isolated eosinophilic granuloma of vertebra L3, in a 15-year-old adolescent. Vertebral instability, due to aggravation of the osteolysis, occurred without neurological symptoms despite orthopedic treatment. Surgery was necessary to correct and stabilize the spinal deformation. Read More

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http://dx.doi.org/10.1016/j.arcped.2017.04.002DOI Listing
July 2017
3 Reads

A rare 'incidentaloma' found on low-dose CT screening for lung cancer: 'scanner beware'.

Postgrad Med 2017 Aug 5;129(6):653-656. Epub 2017 Jun 5.

a VA Connecticut Healthcare System , West Haven , CT , USA.

Screening for lung cancer with low-dose computed tomography (LDCT) has been shown to reduce mortality and has been recommended by the U.S. Preventive Services Task Force for adults 55 to 80 years of age with a 30 pack-year smoking history who are either current smokers or those that quit within 15 years. Read More

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http://dx.doi.org/10.1080/00325481.2017.1334506DOI Listing
August 2017
9 Reads

Langerhans cell histiocytosis (eosinophilic granuloma) of the skull mimicking nummular headache. Report of two cases.

Cephalalgia 2018 04 10;38(4):794-797. Epub 2017 May 10.

1 Department of Neurology & Neurosurgery, Clinical Hospital of University of Chile, Santiago de Chile, Chile.

Background Nummular headache is a rare, recently described topographic headache defined by the circumscribed coin-shaped area of pain. It is classified as a primary headache. There is debate about whether it is due to a peripheral or central disturbance, and its relationship to migraine. Read More

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http://dx.doi.org/10.1177/0333102417708772DOI Listing
April 2018
16 Reads

A rare and unusual case report of Langerhans cell histiocytosis.

J Oral Maxillofac Pathol 2017 Jan-Apr;21(1):140-144

Department of Pedodontics and Preventive Dentistry, AME Dental College and Hospital, Raichur, Karnataka, India.

Langerhans cell histiocytosis (LCH), previously known as histiocytosis X, is an uncommon hematological disorder affecting infants and young children. It is the condition characterized by uncontrolled stimulation and proliferation of normal antigen presenting cells, Langerhans cells. Because of its relatively low incidence, limited data are available regarding the epidemiology of LCH, with estimation of 2-5 cases per million inhabitants per year. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_10_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406796PMC
May 2017
7 Reads

Eosinophilic Granuloma in Jaw Bone: A Pare Pediatric Case Report.

Ethiop J Health Sci 2016 Sep;26(5):487-490

Department of Periodontics, College of Dentistry, Majmaah University, Saudi Arabia.

Background: Eosinophilic granuloma (EG), one of the three clinical forms of Langerhans cell histiocytosis (LCH), is a benign inflammatory reaction to an unknown etiologic agent. It most commonly occurs in children and young adults. The most frequently involved bones are the skull, the ribs and the femurs. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389064PMC
September 2016
13 Reads

Spontaneous and complete regeneration of a vertebra plana after surgical curettage of an eosinophilic granuloma.

Eur Spine J 2017 05 30;26(Suppl 1):225-228. Epub 2017 Mar 30.

Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.

Purpose: The eosinophilic granuloma is a unifocal or multifocal Langerhans cell histiocytosis characterized by an expanding proliferation of Langerhans cells in bones. Skeletal LCH is a rare condition, and vertebral regeneration in cases of vertebral body collapse is even rarer. We report the case of a girl with spontaneous complete healing. Read More

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http://link.springer.com/10.1007/s00586-017-5063-1
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http://dx.doi.org/10.1007/s00586-017-5063-1DOI Listing
May 2017
9 Reads

Right ethmoid eosinophilic angiocentric fibrosis with orbital extension.

Eur Ann Otorhinolaryngol Head Neck Dis 2017 Oct 27;134(5):351-354. Epub 2017 Mar 27.

Service d'ORL et chirurgie cervico-faciale, CHU de Hautepierre, avenue Molière, 67200 Strasbourg, France.

Introduction: Eosinophilic angiocentric fibrosis (EAF) is a slowly progressive, benign disease involving the mucosa of the upper airways or, more rarely, the orbit. It belongs to the spectrum of IgG4-related disease.

Case Report: The authors report the case of a 61-year-old man who presented with orbital involvement (visual loss, pain, proptosis, and eyelid oedema), headache and nasal obstruction. Read More

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http://dx.doi.org/10.1016/j.anorl.2017.02.012DOI Listing
October 2017
7 Reads

Multifocal Eosinophilic Granuloma of Jaws and Skull with Classical and Unusual Radiographic/Imaging Findings.

J Clin Diagn Res 2017 Jan 1;11(1):ZD09-ZD11. Epub 2017 Jan 1.

Senior Lecturer, Department of Oral Medicine and Radiology, CKS Teja Institute of Dental Sciences and Research , Tirupati-Andhra Pradesh, India .

Eosinophilic granuloma is basically a disorder of reticuloendothelial system and is one of the variants of langerhans cell histiocytosis. Multifocal eosinophilic granuloma affecting jaws and skull is relatively a rare disorder. We hereby report a case of multifocal eosinophilic granuloma involving mandible, maxilla and several skull bones. Read More

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http://dx.doi.org/10.7860/JCDR/2017/23732.9154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324510PMC
January 2017
6 Reads

Management of eosinophilic granuloma in pediatric patients: surgical intervention and surgery combined with postoperative radiotherapy and/or chemotherapy.

Childs Nerv Syst 2017 Apr 28;33(4):583-593. Epub 2017 Feb 28.

Department of Spine Surgery, Xiangya Hospital of Central South University, Xiangya Road 87, Changsha, Hunan Province, 410008, China.

Background: Eosinophilic granuloma (EG) of spine in pediatric patients presents kinds of clinical manifestation and a difficult management scenario. The choice of treatment, issues of surgical intervention versus conservative treatment, combination therapy or single treatment, all these factors, including neurological deficits, spinal stability, long-term complications, and continued skeletal growth, must be considered.

Methods: From 2008 to the 2015, 31 pediatric patients of spinal EG were retrospectively reviewed. Read More

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http://dx.doi.org/10.1007/s00381-017-3363-8DOI Listing
April 2017
10 Reads

Your Epoch is not for Trying. It's for Living and for Dying...

Psychiatr Danub 2016 12;28 Suppl 2:191-208

Department of Pathology, Faculty of Medicine, St. Petersburg State University, of. 111, bld. 8A, 21st line V.O., Saint Petersburg, 199106, Russia,

The article is devoted to biographies of three Russian physicians of the Silver Age (a period in the History of Russian culture between 1890 and 1917). They made early, significant and internationally recognized contribution into medical science and became eponymous, although social disasters of the twentieth century caused deep impact on their subsequent lives and careers, so their role was shadowed from global medical community. The article analyzes biographies and academic achievements of A-F. Read More

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December 2016
6 Reads

The surgical strategy for eosinophilic granuloma of the pediatric cervical spine complicated with neurologic deficit and/or spinal instability.

World J Surg Oncol 2016 Dec 7;14(1):301. Epub 2016 Dec 7.

Department of Orthopedic Oncology, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai, 200003, China.

Background: Various therapeutic approaches have been proposed for the treatment of pediatric patients with eosinophilic granuloma (EG) of the cervical spine. Our aim was to discuss and present our experience with the individualized surgical intervention of pediatric cervical EG complicated with neurologic deficits and/or spinal instability.

Methods: We retrospectively analyzed the clinical data of 19 children who were diagnosed with cervical EG comor spinal/or spinal instability (evaluated by the Spinal Instability Neoplastic Score, SINS ≥ 7) and treated surgically in our institution. Read More

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http://dx.doi.org/10.1186/s12957-016-1063-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5141639PMC
December 2016
5 Reads

Spontaneous improvement of cervical kyphosis in eosinophilic granuloma: a case report.

J Pediatr Orthop B 2017 Jan;26(1):95-98

Department of Orthopedic Surgery, Spine Section, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan.

We describe the case of a spontaneous improvement of the cervical kyphosis in eosinophilic granuloma with long-term follow-up. A collapse of the C5 vertebral body was confirmed by cervical spine radiography and computed tomography. The patient wore a sterno-occipitalmandibular immobilizer brace for 6 months, and remodeling of the vertebral body was confirmed 18 months after onset. Read More

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http://dx.doi.org/10.1097/BPB.0000000000000296DOI Listing
January 2017
13 Reads

"Histiocytosis X" - A Rare Case Report.

J Clin Diagn Res 2016 Oct 1;10(10):ZD19-ZD22. Epub 2016 Oct 1.

Postgraduate Student, Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, Sri Ramachandra University , Chennai, Tamil Nadu, India .

Histiocytosis X is an idiopathic disease, characterized by a disorder of the reticulo-endothelial system in the human body. Histopathological studies carried out right from the 1800s have seen a significant similarity in the pathologic process of different stages in particular clinical syndromes showing proliferation of mature histiocytes. It was then modified by Lichenstein in 1953 as "Histiocytosis X". Read More

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http://dx.doi.org/10.7860/JCDR/2016/21614.8691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121822PMC
October 2016
5 Reads

Current concepts for the diagnosis and management of eosinophilic granuloma of bone.

J Orthop Traumatol 2017 Jun 21;18(2):83-90. Epub 2016 Oct 21.

Department of Orthopedics and Orthopedic Oncology, University of Padova, Padova, Italy.

This review summarizes current concepts in the diagnosis and management of the patients with eosinophilic granuloma. Given the benign biology, the clinical course, and the pediatric group of patients that this condition more commonly affects, a treatment approach that carries a lower risk of complications while ensuring a successful cure is desirable. Variable treatment options have been reported with satisfactory results and a recurrence rate of less than 20 %. Read More

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http://dx.doi.org/10.1007/s10195-016-0434-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429252PMC
June 2017
12 Reads

Histiocytosis With Raisinoid Nuclei: A Unifying Concept for Lesions Reported Under Different Names as Nodular Mesothelial/Histiocytic Hyperplasia, Mesothelial/Monocytic Incidental Cardiac Excrescences, Intralymphatic Histiocytosis, and Others: A Report of 50 Cases.

Am J Surg Pathol 2016 11;40(11):1507-1516

*Department of Pathology, Charles University, Biomedical Center †Department of Pathology, Charles University, Medical Faculty and Charles University Hospital Plzen, Plzen ‡Department of Pathology, First Faculty of Medicine and General University Hospital, Charles University in Prague, Prague ¶Department of Pathology, Regional Hospital Benesov, Benesov, Czech Republic §Institute of Pathology, Friedrich-Alexander University Erlangen-Nürnberg, University Hospital, Erlangen ∥Dermatopathologische Gemeinschaftspraxis, Friedrichshafen, Germany.

We report 50 cases of peculiar histiocytic proliferations occurring in diverse body sites that currently bear various names, including nodular mesothelial/histiocytic hyperplasia, nodular histiocytic aggregates, mesothelial/monocytic incidental cardiac excrescences, reactive eosinophilic pleuritis, histioeosinophilic granuloma of the thymus, and intralymphatic histiocytosis. They can sometimes cause considerable differential diagnostic difficulties by resembling a metastatic carcinoma or Langerhans cell histiocytosis. Several previous publications have established a link between some of these conditions, suggesting that these are merely variations within a histopathologic spectrum, affecting different organs and bearing different names based on a particular location. Read More

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http://dx.doi.org/10.1097/PAS.0000000000000687DOI Listing
November 2016
17 Reads

Reconstruction of the C-1 lateral mass with a titanium expandable cage after resection of eosinophilic granuloma in an adult patient.

J Neurosurg Spine 2017 Feb 7;26(2):252-256. Epub 2016 Oct 7.

Department of Neurosurgery, Washington University, Saint Louis, Missouri.

Spinal involvement occurs frequently in cases of eosinophilic granuloma (EG), but surgical treatment is limited primarily to those with spinal instability. Involvement of the cervical spine is rare, but primarily occurs in the vertebral bodies, and is normally amenable to anterior corpectomy and spinal reconstruction. The authors describe a 27-year-old man with pathologically proven EG who presented with complete destruction of the C-1 lateral mass requiring spinal stabilization. Read More

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http://dx.doi.org/10.3171/2016.8.SPINE15523DOI Listing
February 2017
6 Reads

MEDICAL MANAGEMENT OF RECURRENT EOSINOPHILIC GRANULOMA IN TWO BLACK RHINOCEROS (DICEROS BICORNIS).

J Zoo Wildl Med 2016 Sep;47(3):855-861

Recurrent eosinophilic granuloma (EG) in two captive eastern black rhinoceros ( Diceros bicornis michaeli) was effectively managed with glucocorticoids and antihistamines. The first case was a female and the second case was a male. The animals were housed at separate institutions and initially presented with hemorrhagic oral lesions. Read More

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http://dx.doi.org/10.1638/20015-0057.1DOI Listing
September 2016
6 Reads

Sudden sensorineural hearing loss due to an osteolytic lesion.

Eur Ann Otorhinolaryngol Head Neck Dis 2016 Dec 20;133(6):443-444. Epub 2016 Sep 20.

Service d'otologie et d'oto-neurotologie, hospices civils de Lyon, service d'otologie et d'oto-neurotologie, centre hospitalier Lyon Sud, 69495 Pierre-Bénite, France. Electronic address:

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http://dx.doi.org/10.1016/j.anorl.2016.05.010DOI Listing
December 2016
5 Reads