908 results match your criteria Eosinophilic Gastroenteritis


Eosinophilic Gastroenteritis: Clinical Manifestation, Natural Course, and Evaluation of Treatment with Corticosteroids and Vedolizumab.

Dig Dis Sci 2019 Apr 13. Epub 2019 Apr 13.

Department of Gastroenterology and Hepatology, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland.

Background: Eosinophilic gastroenteritis (EGE) is a rare, chronic inflammatory condition of the gastrointestinal tract. Little is known about its natural history and treatment outcomes. The aims of our analysis were to describe clinical presentation, response to current medical treatments, and to evaluate the response of refractory EGE to anti-integrin therapy. Read More

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http://dx.doi.org/10.1007/s10620-019-05617-3DOI Listing

Eosinophilic Gastrointestinal Disorders.

Clin Rev Allergy Immunol 2019 Mar 22. Epub 2019 Mar 22.

Feinberg School of Medicine, Northwestern University, 676 N St. Claire St, Suite 1400, Chicago, IL, 60614, USA.

Eosinophilic gastrointestinal disorders (EGID) are a group of disorders characterized by pathologic eosinophilic infiltration of the esophagus, stomach, small intestine, or colon leading to organ dysfunction and clinical symptoms (J Pediatr Gastroenterol Nutr; Spergel et al., 52: 300-306, 2011). These disorders include eosinophilic esophagitis (EoE), eosinophilic gastritis (EG), eosinophilic gastroenteritis (EGE), eosinophilic enteritis (EE), and eosinophilic colitis (EC). Read More

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http://dx.doi.org/10.1007/s12016-019-08732-1DOI Listing
March 2019
1 Read

Clinical features and treatment outcomes of eosinophilic gastroenteritis : an analysis of 28 cases.

Acta Gastroenterol Belg 2019 Jan-Mar;82(1):5-10

Department of Gastroenterology, Taizhou Hospital of Zhejiang Province, Wenzhou Medical College, 150 Ximen Street, Linhai, Zhejiang Province, China.

Background: Eosinophilic gastroenteritis (EG) is uncommon disease, and the pathogenesis of this disease have yet to be fully clarified.

Aim: This study was to describe the clinical manifestations, endoscopic features and treatment outcomes of a cohort of patients with EG.

Method: This retrospective study was included 28 consecutive patients who were diagnosed EG between January 2011 and December 2015 in Taizhou Hospital. Read More

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Causes of eosinophilic ascites - a systematic review.

Rom J Intern Med 2018 Dec 1. Epub 2018 Dec 1.

Carol Davila School of Medicine, Bucharest, Romania.

Background: In the last years an uprising interest for a relatively unknown entity, eosinophilic ascites (EA), has been recorded. Our aim is to investigate the potential causes of EA development, as well as clinical, laboratory, endoscopic and radiologic features, management and outcome in these patients.

Methods: The following research was performed on PubMed (MEDLINE) database using the medical subject headings [Mesh] terms "Ascites" AND "Eosinophils". Read More

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http://content.sciendo.com/view/journals/rjim/ahead-of-print
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http://dx.doi.org/10.2478/rjim-2018-0041DOI Listing
December 2018
10 Reads

Impaired Health-Related Quality of Life in Adolescent Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: The Impact of Core Symptoms.

Front Pediatr 2019 15;7:26. Epub 2019 Feb 15.

Division of General Pediatrics and Adolescent Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

The objectives of this study were to compare the health-related quality of life (HRQOL) of a North American population of adolescents and young adults with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) to (1) healthy controls (HC), (2) adolescents with ME/CFS in other countries, and (3) other forms of pediatric chronic illness, and (4) to examine the influence of the core illness symptoms in the Institute of Medicine (IOM) case definition on impaired HRQOL. Cross-sectional study comparing individuals with ME/CFS referred to a tertiary care Chronic Fatigue clinic and HC. Eligible participants were age 10-30 years and met the Fukuda criteria for CFS. Read More

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http://dx.doi.org/10.3389/fped.2019.00026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385524PMC
February 2019
1 Read

Eosinophilic Gastrointestinal Diseases in Childhood.

Ann Nutr Metab 2018 19;73 Suppl 4:18-28. Epub 2019 Feb 19.

Division on Gastroenterology, Hepatology and Nutrition, First Department of Pediatrics, University of Athens, Children's Hospital "Agia Sofia", Athens, Greece,

Eosinophilic gastrointestinal diseases (EGIDs) comprise a group of chronic, inflammatory diseases of the gastrointestinal (GI) tract, that are characterized, clinically, by symptoms related to the dysfunction of the involved segment(s) of the GI tract, and histologically, by dense eosinophilic inflammation, in the absence of an identifiable secondary cause. The group of EGIDs comprises eosinophilic esophagitis (EoE), eosinophilic gastritis (EG), eosinophilic gastroenteritis (EGE), and eosinophilic colitis (EC). EoE is the most common and the best described EGID compared to EG, EGE, and EC. Read More

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http://dx.doi.org/10.1159/000493668DOI Listing
February 2019
2 Reads

Predictable and Unusual Adverse Effects of Immunosuppression in Pediatric Liver Transplant Patients.

Exp Clin Transplant 2019 01;17(Suppl 1):230-233

From the Department of Pediatric Gastroenterology,Gazi University Faculty of Medicine, Ankara, Turkey.

Objectives: Our aim was to determine potentially adverse effects of immunosuppressive protocols after liver transplantation in children.

Materials And Methods: The medical records of 60 children who underwent liver transplant retrospectively analyzed. Corticosteroid, tacrolimus, and mycophenolate mofetil were the primary immunosuppressive agents used in our center. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.P81DOI Listing
January 2019
4 Reads

Modified oral enteric-coated budesonide regimens to treat pediatric eosinophilic gastroenteritis, a single center experience.

J Allergy Clin Immunol Pract 2019 Feb 11. Epub 2019 Feb 11.

Division of Allergy and Immunology, Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Pediatrics, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, Pa.

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http://dx.doi.org/10.1016/j.jaip.2019.01.053DOI Listing
February 2019
10 Reads

Abnormal thymic stromal lymphopoietin expression in the gastrointestinal mucosa of patients with eosinophilic gastroenteritis.

J Pediatr (Rio J) 2019 Feb 11. Epub 2019 Feb 11.

Children's Hospital Affiliated to Nanjing Medical University, Department of Gastroenterology, Nanjing, China. Electronic address:

Objective: To investigate the differential expression of the thymic stromal lymphopoietin isoforms, short and long, and discern their biological implications under eosinophilic gastroenteritis.

Methods: The expression of thymic stromal lymphopoietin and its two isoforms in tissues was assessed by quantitative RT-PCR in healthy controls (n=24) and patients with eosinophilic gastroenteritis (n=17).

Results: Thymic stromal lymphopoietin mRNA was significantly reduced in eosinophilic gastroenteritis when compared with healthy controls (p<0. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00217557183086
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http://dx.doi.org/10.1016/j.jped.2018.11.012DOI Listing
February 2019
5 Reads

A Case of Eosinophilic Gastroenteritis Associated with Eosinophilic Ascites Diagnosed by Full-Thickness Biopsy of the Small Intestine.

Am J Case Rep 2019 Feb 13;20:189-193. Epub 2019 Feb 13.

College of Medicine, King Saud University, Riyadh, Saudi Arabia.

BACKGROUND Eosinophilic gastroenteritis is a rare disease, characterized by infiltrates of eosinophils in the intestinal mucosa, muscularis propria, and serosa. Eosinophilic gastroenteritis is due to Type 1 hypersensitivity and can be associated with other atopic diseases. The clinical course of eosinophilic gastroenteritis varies depending on the location, extent, and depth of eosinophilic infiltration of the gastrointestinal tract, which can make the diagnosis challenging. Read More

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http://dx.doi.org/10.12659/AJCR.913319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380204PMC
February 2019
2 Reads

Eosinophilic Colitis Associated with Emtricitabine/Tenofovir.

Cureus 2018 Oct 26;10(10):e3498. Epub 2018 Oct 26.

Internal Medicine, University of Miami, Holy Cross Hospital, Fort Lauderdale, USA.

Eosinophilic gastroenteritis (EGE) is a rare disease occurring commonly in patients with a history of allergies, asthma, food sensitivities, or parasite exposure. The condition has been postulated to occur when eosinophils accumulate at the intestinal epithelium resulting in inflammation, recruitment and degranulation of mast cells, and further propagation of eosinophil activation. While laboratory and microbiological data may point to the diagnosis, the condition is only confirmed via biopsy demonstrating the eosinophilic infiltration of the intestinal epithelium. Read More

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http://dx.doi.org/10.7759/cureus.3498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318128PMC
October 2018
3 Reads

Abdominal ascites in children as the presentation of eosinophilic gastroenteritis: A surgeon's perspective.

Clin Res Hepatol Gastroenterol 2019 Apr 6;43(2):e12-e17. Epub 2018 Dec 6.

Department of Pediatric Surgery, Shengjing Hospital of China Medical University, 36, Sanhao Street, Heping district, Shenyang 110004, PR China. Electronic address:

Background: Abdominal ascites is a common problem in general surgery. The causes include parasitic diseases, tuberculosis, malignancies, hypoalbuminemia, abdominal inflammatory diseases, and peritonitis. Eosinophilic gastroenteritis (EG) has also been reported to be an infrequent cause. Read More

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http://dx.doi.org/10.1016/j.clinre.2018.11.003DOI Listing
April 2019
1 Read

Eosinophil Counts in Mucosal Biopsies of the Ileum and Colon: Interobserver Variance Affects Diagnostic Accuracy.

Patholog Res Int 2018 4;2018:2638258. Epub 2018 Nov 4.

Department of Gastroenterology and Hepatology, University Medical Center Brandenburg, Brandenburg, Germany.

Primary eosinophilic gastroenteritis and colitis (EGE) is a rare entity with unspecific clinical and endoscopic findings. Validated histopathologic criteria for confirming the diagnosis are lacking, because numeric values for normal or elevated concentrations of eosinophils in mucosal biopsies are varying between observers. To quantify this interobserver variance, we had the same set of 30 slides of eosinophilic-rich mucosal biopsies from the ileum and colon systematically reviewed by a panel of six independent pathologists, each with more than a ten-year experience in the field. Read More

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http://dx.doi.org/10.1155/2018/2638258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241360PMC
November 2018
3 Reads

Eosinophilic Enteropathy Presenting as Small Bowel Obstruction.

Am Surg 2017 Nov;83(11):e430-e432

American University of the Carribbean, Cupecoy, St. Maarten.

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November 2017
2 Reads

Consortium of Eosinophilic Gastrointestinal Disease Researchers: Advancing the Field of Eosinophilic GI Disorders Through Collaboration.

Gastroenterology 2019 03 17;156(4):838-842. Epub 2018 Nov 17.

Division of Allergy and Immunology, Department of Pediatrics, University of Cincinnati College of Medicine/Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

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http://dx.doi.org/10.1053/j.gastro.2018.10.057DOI Listing
March 2019
10 Reads

Eosinophilic gastroenteritis complicating acute calculus eosinophilic cholecystitis 6 months after cholecystectomy.

Authors:
Chee K Hui

J Dig Dis 2018 Nov 28;19(11):693-695. Epub 2018 Nov 28.

Department of Gastroenterology, Center for Digestive Diseases, Kuala Lumpur, Malaysia.

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http://doi.wiley.com/10.1111/1751-2980.12683
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http://dx.doi.org/10.1111/1751-2980.12683DOI Listing
November 2018
13 Reads

Can Eosinophilic Esophagitis Cause Achalasia and Other Esophageal Motility Disorders?

Am J Gastroenterol 2018 Nov 12;113(11):1594-1599. Epub 2018 Oct 12.

Division of Gastroenterology and Center for Esophageal Diseases, Baylor University Medical Center, and the Center for Esophageal Research, Baylor Scott & White Research Institute, Dallas, Texas, USA.

Eosinophilic esophagitis (EoE), a disorder identified by its esophageal mucosal features, often is associated with esophageal motility abnormalities, which are manifestations of esophageal muscle dysfunction. Those motility abnormalities sometimes normalize with treatments that reduce esophageal eosinophilia, suggesting that eosinophils can cause reversible esophageal motility disturbances, perhaps by releasing myoactive and neuroactive eosinophil products. Although achalasia uncommonly is associated with EoE as currently defined, most achalasia patients have evidence of an abnormal accumulation of eosinophils and/or their degranulation products in the esophageal muscularis propria, a location inaccessible to routine endoscopic evaluation. Read More

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http://dx.doi.org/10.1038/s41395-018-0240-3DOI Listing
November 2018
66 Reads

[Recent progress in the research of Eosinophilic GastroIntestinal Diseases (EGIDs)].

Nihon Yakurigaku Zasshi 2018 ;152(4):175-180

Department of Gastroenterology and Hepatology, Shimane University, Faculty of Medicine.

Eosinophilic esophagitis (EoE) and eosinophilic gastroenteritis (EGE), which are included in eosinophilic gastrointestinal disorders (EGIDs), are allergic gastrointestinal diseases mainly caused by food allergens, which features dense infiltration of eosinophiles in the gastrointestinal mucosa. A possible mechanism of these diseases are Th2 type allergic reactions, including IL-5, IL-13, and IL-15, thymic stromal protein (TSLP), and eotaxin 3, which are considered to have important roles. The number of patients with EoE is rapidly increasing in both Western and Asian countries. Read More

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https://www.jstage.jst.go.jp/article/fpj/152/4/152_175/_arti
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http://dx.doi.org/10.1254/fpj.152.175DOI Listing
January 2018
5 Reads

Assessment of eosinophils in gastrointestinal inflammatory disease of dogs.

J Vet Intern Med 2018 Nov 7;32(6):1911-1917. Epub 2018 Oct 7.

Department of Veterinary and Biomedical Sciences, University of Minnesota, St. Paul, Minnesota.

Background: Accurate identification of eosinophils in the gastrointestinal (GI) tract of dogs with eosinophilic GI disease (EGID) by histological evaluation is challenging. The currently used hematoxylin and eosin (H&E) staining method detects intact eosinophils but does not detect degranulated eosinophils, thus potentially underrepresenting the number of infiltrating eosinophils.

Objective: To develop a more sensitive method for identifying and quantifying both intact and degranulated eosinophils to diagnose EGID more accurately. Read More

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http://doi.wiley.com/10.1111/jvim.15310
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http://dx.doi.org/10.1111/jvim.15310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271348PMC
November 2018
2 Reads

Hypereosinophilia and epigastralgia after visiting Tunisia: a rare differential diagnosis of helminthiases.

Med Sante Trop 2018 Aug;28(3):334-336

Service de maladies infectieuses et tropicales, Hôpital d'instruction des armées Bégin, 94160 Saint Mandé, France.

Causes of hypereosinophilia among travelers returning from North Africa are dominated by helminth infections, especially when associated with gastrointestinal signs. Non-infectious causes must nonetheless be investigated after negative microbiological assessment and failure of a broad empiric antiparasite treatment. We report the case of a young man with epigastralgia and major weight loss since a stay in Tunisia. Read More

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http://www.john-libbey-eurotext.fr/medline.md?doi=10.1684/ms
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http://dx.doi.org/10.1684/mst.2018.0806DOI Listing
August 2018
2 Reads

[A retrospective study of the clinical characteristics and treatment of 93 adult patients with eosinophilic gastroenteritis].

Nihon Shokakibyo Gakkai Zasshi 2018;115(9):797-803

Department of Gastroenterology, Kawasaki Hospital.

We performed a retrospective analysis on three patients diagnosed with EGE (eosinophilic gastroenteritis) at our hospital and 90 cases obtained from a case database. The cases' genders, ages, peripheral eosinophils, ascites, endoscopic findings, biopsy findings, diagnostic scores, and rates of glucocorticoid use were evaluated. The gender ratio was 40 males to 53 females, and the median age was 50. Read More

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http://dx.doi.org/10.11405/nisshoshi.115.797DOI Listing
January 2018
18 Reads

Clinical and pathological profile of eosinophilic gastroenteritis.

Eur J Gastroenterol Hepatol 2019 02;31(2):157-162

Division of Gastroenterology and Hepatology, Niigata University Medical and Dental Hospital, Niigata, Japan.

Background: Eosinophilic gastroenteritis (EoGE) can be diagnosed on the basis of histologic criteria; however, the pathology is considered to be heterogeneous. There is no consensus on the management of this enigmatic disorder with an unknown etiology.

Patients And Methods: Data for patients diagnosed with EoGE and followed up over a 1-year period were analyzed. Read More

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http://dx.doi.org/10.1097/MEG.0000000000001241DOI Listing
February 2019
3 Reads

Massive hemorrhagic ascites: A rare presentation of eosinophilic gastroenteritis.

World J Clin Cases 2018 Jul;6(7):156-160

Department of Gastroenterology, the Eighth Affiliated Hospital of Guangxi Medical University, Guigang 537100, Guangxi Zhuang Autonomous Region, China.

According to Klein's classification system, the symptomatology of eosinophilic gastroenteritis (EG), a rare disease, differs based on the affected tissue layer. Patients with subserosal EG often have peritoneal effusion. Hemorrhagic ascites due to EG is extremely rare and has not been reported in the literature. Read More

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http://dx.doi.org/10.12998/wjcc.v6.i7.156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068814PMC
July 2018
5 Reads

Phenotypic Characterization of Eosinophilic Esophagitis in a Large Multicenter Patient Population from the Consortium for Food Allergy Research.

J Allergy Clin Immunol Pract 2018 Sep - Oct;6(5):1534-1544.e5. Epub 2018 Aug 1.

Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Background: Eosinophilic esophagitis (EoE) is increasingly common, but data on phenotypic aspects are still incomplete.

Objectives: To describe the clinical, endoscopic, and histopathologic features of a large number of children and adults with EoE across the United States.

Methods: This was a multisite single visit registry enrolling subjects aged 6 months to 65 years with EoE. Read More

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http://dx.doi.org/10.1016/j.jaip.2018.05.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6132253PMC
August 2018
24 Reads

Eosinophilic Ascites: Singular Presentation of Eosinophilic Gastrointestinal Disorder.

J Investig Allergol Clin Immunol 2018 Aug;28(4):275-276

Digestive Unit, Hospital HLA Jerez Puerta del Sur, Jerez de la Frontera, Spain.

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http://dx.doi.org/10.18176/jiaci.0260DOI Listing

Severe asthma with eosinophilic gastroenteritis effectively managed by mepolizumab and omalizumab.

Ann Allergy Asthma Immunol 2018 Dec 27;121(6):742-743. Epub 2018 Jul 27.

CEO of Toronto Allergists, CEO of Evidence Based Medical Educator Inc., Section Head of Asthma at the Canadian Society of Clinical Immunology and Allergy, Toronto, Ontario, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10811206183061
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http://dx.doi.org/10.1016/j.anai.2018.07.030DOI Listing
December 2018
47 Reads

[Clinical analysis of eosinophilic gastroenteritis in 71 children].

Zhonghua Er Ke Za Zhi 2018 Jul;56(7):500-504

Department of Gastroenterology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Faculty of Digestive Diseases, Capital Medical University, National Clinical Research Center for Digestive Diseases, Beijing 100045, China.

To summarize the clinical data including manifestations, diagnosis, treatment and prognosis of eosinophilic gastroenteritis (EGE) in children. A retrospective analysis was performed in 71 patients with pathologically proven EGE at Beijing Children's Hospital Affiliated to Capital Medical University from January 2008 to January 2017. Their clinical manifestations, laboratory and imaging examinations, endoscopic findings, histopathological examinations, and treatment were collected and analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1310.2018.07.006DOI Listing

Eosinophils in the gastrointestinal tract: how much is normal?

Virchows Arch 2018 Sep 10;473(3):313-320. Epub 2018 Jul 10.

Department of Paediatrics, Centro Hospitalar São João, Porto, Portugal.

The normal density of eosinophils in the digestive mucosa of children has been rarely addressed despite being important to provide baseline counts for the diagnosis of eosinophilic gastrointestinal disorders (EGID). Histopathological criteria for EGID remain undefined and there has been little consistency of results in different populations. We aimed to establish the eosinophil density of the normal digestive mucosa in a paediatric population submitted to endoscopic procedures with normal histological features. Read More

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http://dx.doi.org/10.1007/s00428-018-2405-2DOI Listing
September 2018
14 Reads

[Epidemiological, clinical and diagnostic characterization of children with eosinophilic gastroenteropathy. A retrospective study of three high complexity health institutions].

Rev Alerg Mex 2018 Apr-Jun;65(2):148-159

Universidad de Antioquía, Facultad de Medicina, Grupo de Alergología Clínica Experimental, Medellín, Colombia.

Background: Eosinophilic gastrointestinal disorders (EGID) are uncommon. In Colombia there are no studies in the pediatric population.

Objective: To describe the epidemiological, clinical and diagnostic characteristics of a pediatric population with EGID. Read More

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http://dx.doi.org/10.29262/ram.v65i2.354DOI Listing
July 2018
9 Reads

Diagnosis, Natural History and Treatment of Eosinophilic Enteritis: a Review.

Curr Gastroenterol Rep 2018 Jul 2;20(8):37. Epub 2018 Jul 2.

Gastroenterology Department, Saint-Eloi Hospital, Montpellier University Hospital, Montpellier, France.

Purpose Of Review: To review recent findings regarding eosinophilic enteritis, including epidemiology, pathogenesis, natural history, and treatment.

Recent Findings: A 2017 population-based study using a US healthcare system database identified 1820 patients with a diagnosis of eosinophilic enteritis among 35,826,830 individuals. The majority of patients with eosinophilic enteritis in this study were women (57. Read More

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http://dx.doi.org/10.1007/s11894-018-0645-6DOI Listing
July 2018
9 Reads

Takayasu's arteritis associated with eosinophilic gastroenteritis, possibly via the overactivation of Th17.

Gut Pathog 2018 12;10:22. Epub 2018 Jun 12.

2Division of Metabolism and Biosystemic Science, Department of Medicine, Asahikawa Medical University, Asahikawa, Japan.

Background: Takayasu's arteritis (TA) is a large-vessel vasculitis pathologically characterized by granulomatous necrotizing vasculitis with giant cells. Although the cause of TA is still unclear, genetic factors as well as immunological abnormalities, particularly the overactivation of Th1 and Th-17, are considered to play important roles in the pathogenesis of this disease. Eosinophilic gastroenteritis (EGE) is a type of refractory inflammation in which numerous eosinophils infiltrate the inflammatory area. Read More

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http://dx.doi.org/10.1186/s13099-018-0251-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5996549PMC
June 2018
21 Reads

Eosinophilic gastrointestinal diseases beyond eosinophilic esophagitis.

Ann Allergy Asthma Immunol 2018 08 22;121(2):162-167. Epub 2018 Jun 22.

Gastrointestinal Eosinophilic Disease Program, University of Colorado School of Medicine, Aurora, Colorado; Digestive Health Institute, Department of Pediatrics, Children's Hospital of Colorado, Aurora, Colorado.

Objective: Eosinophilic gastrointestinal diseases (EGIDs) are a rare group of disorders that can have varied clinical presentations dependent on the involved segment within the gastrointestinal tract. Eosinophilic gastritis presents with abdominal pain or vomiting, eosinophilic gastroenteritis presents with diarrhea and anemia or hypoalbuminemia, and eosinophilic colitis can present with diarrhea or bloody stools. These nonspecific symptoms remain poorly understood in their relation to the underlying pathogenesis, but a significant percentage of patients have atopy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10811206183050
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http://dx.doi.org/10.1016/j.anai.2018.06.013DOI Listing
August 2018
2 Reads

Ascites in a Young Woman: A Rare Presentation of Eosinophilic Gastroenteritis.

Case Rep Gastrointest Med 2018 10;2018:1586915. Epub 2018 May 10.

Department of Internal Medicine, Radiology, University Hospital Center "Sousa Martins", Guarda, Portugal.

Introduction: Eosinophilic gastroenteritis (EGE) is a rare idiopathic disease that can affect one or more organs of the digestive tract. It has an estimated incidence of 1-20 cases per 100,000 patients. Klein et al. Read More

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http://dx.doi.org/10.1155/2018/1586915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971316PMC
May 2018
10 Reads

Successful Food-Elimination Diet in an Adult with Eosinophilic Gastroenteritis.

ACG Case Rep J 2018 23;5:e38. Epub 2018 May 23.

Department of Gastroenterology and Hepatology, Shimane University School of Medicine, Izumo, Japan.

We successfully treated a 22-year-old woman with eosinophilic gastroenteritis (EGE) using a multiple food-elimination diet. The patient was diagnosed with EGE based on histopathological findings and initially treated with oral prednisolone. The symptoms immediately improved, although they recurred when prednisolone was tapered to a low dose. Read More

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http://dx.doi.org/10.14309/crj.2018.38DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968151PMC
May 2018
9 Reads

Myotonic dystrophy type 1 and pseudo-obstruction in a child with smooth muscle α-actin deficiency and eosinophilic myenteric plexitis.

Turk J Gastroenterol 2018 03;29(2):226-229

Division of Gastroenterology, Department of Medicine, University of Perugia Medical School, Perugia, Italy.

Myotonic dystrophy (MD) frequently involves the gastrointestinal tract, where it can manifest as chronic intestinal pseudo-obstruction (CIPO), particularly in adults. This manifestation is quite uncommon in children. We report the case of a 12-year-old boy with MD type 1 and CIPO, in which a pathologic assessment revealed an association with smooth muscle α-actin deficiency in the external muscular layer of the ileum, and with features of eosinophilic plexitis and eosinophilic muscle infiltration in the colon. Read More

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http://www.turkjgastroenterol.org/eng/makale/5258/306/Full-T
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http://dx.doi.org/10.5152/tjg.2018.17582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284701PMC
March 2018
8 Reads

Mepolizumab use: Post-approval academic practice experience.

Ann Allergy Asthma Immunol 2018 07 10;121(1):126-128. Epub 2018 Apr 10.

Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois. Electronic address:

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http://dx.doi.org/10.1016/j.anai.2018.04.001DOI Listing

Gastrointestinal food allergy in Ghanaian children: a case series.

Ghana Med J 2017 Sep;51(3):138-142

Paediatric Surgery Unit, Department of Paediatric Surgery, Korle Bu Teaching Hospital, Accra, Ghana.

Background: Food allergy is an adverse health effect arising from a specific immune response that occurs reproducibly on exposure to a given food. Food allergies are classified into three types: Ig(immunoglobulin)E mediated, mixed IgE and cell mediated and cell-mediated non IgE mediated. Gastrointestinal (GIT) food allergy has classically encompassed a number of different clinical entities: food protein-induced enterocolitis syndrome (FPIES), food protein-induced proctocolitis (FPIP), food protein-induced enteropathy and eosinophilic gastrointestinal disorders (EGID). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870227PMC
September 2017
5 Reads

Eosinophilic Gastroenteritis and Colitis: Not Yet Ready for the Big Leagues.

J Pediatr Gastroenterol Nutr 2018 Jul;67(1):1-2

Gastrointestinal Eosinophilic Diseases Program, Department of Pediatrics, University of Colorado School of Medicine.

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http://dx.doi.org/10.1097/MPG.0000000000001998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013369PMC
July 2018
8 Reads

Individuals affected by eosinophilic gastrointestinal disorders have complex unmet needs and frequently experience unique barriers to care.

Clin Res Hepatol Gastroenterol 2018 10 31;42(5):483-493. Epub 2018 Mar 31.

Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.

Introduction: Eosinophilic gastrointestinal disorders (EGIDs) are a rare but emerging healthcare problem. Patient advocacy groups (PAGs) have an important role in representing the EGID community, and serve as valuable research partners. By leveraging the partnership between medical researchers and PAGs, we examined the unmet needs and barriers to care perceived by individuals affected by EGIDs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22107401183004
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http://dx.doi.org/10.1016/j.clinre.2018.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167209PMC
October 2018
11 Reads

Vedolizumab Treatment May Reduce Steroid Burden and Improve Histology in Patients With Eosinophilic Gastroenteritis.

Clin Gastroenterol Hepatol 2018 Dec 27;16(12):1992-1994. Epub 2018 Mar 27.

Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2018.03.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160359PMC
December 2018
5 Reads

Nationwide questionnaire-based survey of oral immunotherapy in Japan.

Allergol Int 2018 Jul 20;67(3):399-404. Epub 2018 Mar 20.

Department of Allergy, Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Sagamihara, Japan; Study Group on the "Establishment of New Management Method of Food Allergy in Children" in the Practical Research Project for Allergic Disease and Immunology of Japan Agency for Medical Research and Development, AMED, Tokyo, Japan. Electronic address:

Background: Clinical trials on oral immunotherapy (OIT) have been increasing for nearly a decade; however, several national guidelines do not recommend OIT as a standardized procedure. The aim of this study was to obtain insights into the current use and practice of OIT in Japan.

Methods: A first questionnaire was mailed to 524 training and teaching facilities of the Japan Pediatric Society. Read More

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http://dx.doi.org/10.1016/j.alit.2018.02.006DOI Listing
July 2018
12 Reads

Eosinophilic gastroenteritis: An unusual presentation of a rare disease.

Rev Gastroenterol Mex 2019 Jan - Mar;84(1):116-118. Epub 2018 Mar 17.

Patología, Hospital Pablo Tobón Uribe; Universidad Pontificia Bolivariana, Medellín, Colombia.

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http://dx.doi.org/10.1016/j.rgmx.2018.01.001DOI Listing
March 2018
2 Reads

Eosinophilic gastroenteritis and other eosinophilic gut diseases distal to the oesophagus.

Lancet Gastroenterol Hepatol 2018 04 7;3(4):271-280. Epub 2018 Mar 7.

Faculty of Health and Medicine, University of Newcastle, HMRI Building, New Lambton, NSW, Australia. Electronic address:

Under normal physiological conditions, eosinophils are present throughout the gastrointestinal tract distal to the squamous oesophagus. Increases in their numbers signify primary and secondary eosinophilic conditions. The rare primary eosinophilic diseases eosinophilic gastroenteritis and eosinophilic colitis affect fewer than ten in 100 000 people, and are characterised by numerous mucosal eosinophils, distributed in sheets and sometimes extending from the mucosa into the submucosa. Read More

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http://dx.doi.org/10.1016/S2468-1253(18)30005-0DOI Listing
April 2018
6 Reads

Incidence of Childhood Eosinophilic Esophagitis in Central Brazil: How Many Are We Missing?

J Investig Allergol Clin Immunol 2018 13;28(4):241-245. Epub 2018 Mar 13.

Pediatrics Department, Clinical Hospital of Universidade Federal de Uberlândia, Uberlândia, Brazil.

Background: Few studies have assessed the incidence of eosinophilic esophagitis (EoE) in childhood. Our study aimed to determine the incidence of EoE in pediatric patients undergoing upper gastrointestinal endoscopy (UGE), with analysis of epidemiological data including sex, age, symptoms, frequency of atopy, and endoscopic and histological findings.

Methods: We performed a retrospective, observational, analytical study of the medical records of patients aged 0 to 14 years who underwent UGE in a tertiary hospital from January 2004 to January 2014. Read More

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http://dx.doi.org/10.18176/jiaci.0241DOI Listing
March 2018
2 Reads

Quantification of the duodenal eosinophil content in adults: a necessary step for an evidence-based diagnosis of duodenal eosinophilia.

Aliment Pharmacol Ther 2018 Apr 27;47(8):1143-1150. Epub 2018 Feb 27.

Miraca Life Sciences, Irving, TX, USA.

Background: The normal content of eosinophils in the adult duodenum remains undefined. Therefore, there is no foundation for evidence-based criteria to diagnose eosinophilic duodenitis.

Aim: This study aimed at: (1) establishing the range of the eosinophil density in the mucosa of the duodenum of normal adults, and (2) determining the biopsy-based prevalence of isolated eosinophilic duodenitis in a large population of adults. Read More

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http://doi.wiley.com/10.1111/apt.14558
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http://dx.doi.org/10.1111/apt.14558DOI Listing
April 2018
7 Reads

Impact on Health-Related Quality of Life in Adults with Eosinophilic Gastritis and Gastroenteritis: A Qualitative Assessment.

Dig Dis Sci 2018 05 23;63(5):1148-1157. Epub 2018 Feb 23.

Division of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, 676 N. Saint Clair St. #1400, Chicago, IL, 60611, USA.

Background: Eosinophilic gastritis (EG) and eosinophilic gastroenteritis (EGE) are chronic immune-mediated conditions of the digestive tract, which affect the stomach only, or the stomach and small intestines, respectively. Though these disorders are uncommon, they are being increasingly recognized and diagnosed. While health-related quality of life (HRQOL) has been evaluated in other eosinophilic gastrointestinal diseases, this study is the first to describe HRQOL impacts unique to EG/EGE. Read More

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http://link.springer.com/10.1007/s10620-018-4978-7
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http://dx.doi.org/10.1007/s10620-018-4978-7DOI Listing
May 2018
14 Reads

Eosinophilic Gastroenteritis in Which Obstructive Jaundice Developed due to Invagination of the Duodenal Wall.

Intern Med 2018 Jul 9;57(13):1841-1847. Epub 2018 Feb 9.

Digestive and Lifestyle Diseases, Kagoshima University Graduate School of Medical and Dental Sciences, Japan.

A 63-year-old woman was admitted with epigastric pain, eosinophilia, and elevated hepatobiliary enzyme levels. An upper gastrointestinal endoscopic examination showed that the mucosa of the gastroduodenal wall was edematous. Eosinophilic gastroenteritis (EGE) was diagnosed based on eosinophilic infiltration of the gastroduodenal mucosa. Read More

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http://dx.doi.org/10.2169/internalmedicine.9312-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6064693PMC
July 2018
8 Reads

Eosinophilic Gastroenteritis Presenting With Gastric Perforation.

Clin Gastroenterol Hepatol 2019 Mar 31;17(4):e31-e32. Epub 2018 Jan 31.

Department of Gastroenterology, National Hospital Organization Fukuyama Medical Center, Fukuyama, Japan.

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http://dx.doi.org/10.1016/j.cgh.2018.01.014DOI Listing
March 2019
1 Read

Intestinal overexpression of interleukin (IL)-15 promotes tissue eosinophilia and goblet cell hyperplasia.

Immunol Cell Biol 2018 03 29;96(3):273-283. Epub 2017 Dec 29.

Department of Medicine, Section of Pulmonary Diseases, Tulane Eosinophilic Disorder Center, Tulane University School of Medicine, New Orleans, LA, 70112, USA.

Interleukin (IL)-15 overexpression in eosinophilic gastrointestinal disorders is reported, but IL-15's role in promoting eosinophilic gastroenteritis is largely unknown. Therefore, we generated enterocyte-overexpressed IL-15 transgenic mice using Fabpi promoter. The Fabpi-IL-15 (iIL-15) transgenic mice showed induced IL-15 levels in the jejunum with a marked increase in jejunum eosinophils. Read More

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http://dx.doi.org/10.1111/imcb.1036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866184PMC
March 2018
3 Reads
4.150 Impact Factor

Eosinophilic Ascites-Rarest Presentation of a Rare Disease, Eosinophilic Gastroenteritis.

J Assoc Physicians India 2017 Sep;65(9):93-94

Saifee Hospital, Mumbai, Maharashtra.

Eosinophilic gastroenteritis (EGE) is an uncommon disease of unknown etiology reported in both adult and pediatric age group. Here we report a case of a 46-year-old HIV positive female who presented to us with ascites and abdominal distension with peripheral eosinophilia and diagnosed as EGE. Read More

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September 2017
3 Reads