1,038 results match your criteria Eosinophilic Gastroenteritis


Eosinophilic ascites as an uncommon presentation of eosinophilic gastroenteritis: A case report.

Arab J Gastroenterol 2021 Jun 2. Epub 2021 Jun 2.

Department of Hepatogastroenterology, Theodor Bilharz Research Institute, Giza, Egypt; Department of Pathology, Theodor Bilharz Research Institute, Giza, Egypt; Department of Tropical Medicine and Hepatogastroenterology, Faculty of Medicine, Cairo University, Cairo, Egypt; Service d'Hépatologie, Hôpital Beaujon, APHP, Clichy-la-Garenne, CRI-UMR 1149, Inserm and Université de Paris, Paris, France.

Background: Eosinophilic gastroenteritis (EGE) is defined by the presence of gastrointestinal symptoms, with an abnormal eosinophilic infiltrate of the intestine wall and exclusion of other causes of secondary eosinophilia. EGE has three clinical presentations, depending on the depth of eosinophilic infiltration of the bowel wall. It individualizes into three types, namely mucosal, muscular, and subserosal. Read More

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Eosinophilic appendicitis due to : a challenging differential diagnosis for clinicians.

BMJ Case Rep 2021 Jun 1;14(6). Epub 2021 Jun 1.

Department of Histopathology, Hospital Universitario de Móstoles, Móstoles, Madrid, Spain.

A 45-year-old man presents with 48-hour status of high temperature, cough and dyspnoea. In the context of pandemic, the patient is initially diagnosed with COVID-19 syndrome. Later, the laboratory and ultrasound study supported acute appendicitis diagnosis. Read More

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Eosinophilic gastroenteritis: Clinical characteristics and management.

Indian J Gastroenterol 2021 Jun 28;40(3):338-343. Epub 2021 May 28.

Institute of Digestive and Hepatopancreatobiliary Sciences, Sakra World Hospital, Sy No. 52/2 & 52/3, Devarabeesanahalli, Bangalore, 560 103, India.

There is paucity of published data related to eosinophilic gastroenteritis (EGE). We aimed to study the clinical characteristics, management, and follow-up of EGE. From March 2014 to December 2018, patients with gastrointestinal (GI) symptoms suspected to have EGE were investigated. Read More

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Eosinophils as Major Player in Type 2 Inflammation: Autoimmunity and Beyond.

Adv Exp Med Biol 2021 May 26. Epub 2021 May 26.

Humanitas Clinical and Research Center - IRCCS, Milan, Italy.

Eosinophils are a subset of differentiated granulocytes which circulate in peripheral blood and home in several body tissues. Along with their traditional relevance in helminth immunity and allergy, eosinophils have been progressively attributed important roles in a number of homeostatic and pathologic situations. This review aims at summarizing available evidence about eosinophils functions in homeostasis, infections, allergic and autoimmune disorders, and solid and hematological cancers. Read More

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Acute-Onset Eosinophilic Gastroenteritis and Ascites Secondary to Occult Toxocariasis.

ACG Case Rep J 2021 Apr 20;8(4):e00556. Epub 2021 Apr 20.

Department of Medicine, University of Minnesota, Minneapolis, MN.

Eosinophilic gastroenteritis is a rare entity, and although usually idiopathic, it may arise from gastrointestinal infections. We report a case of a 33-year-old woman from Vietnam presenting with acute abdominal pain, new-onset eosinophilic ascites, peripheral eosinophilia, and a positive antibody. The patient had no recent international travel, known animal host contact, or other toxocariasis risk factors. Read More

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Utility of gastric and duodenal biopsy sampling in adult eosinophilic esophagitis patients to rule out other gastrointestinal disorders.

Scand J Gastroenterol 2021 May 9;56(5):613-620. Epub 2021 Apr 9.

Department of Gastroenterology & Hepatology, Amsterdam University Medical Center, Amsterdam, The Netherlands.

Rationale: According to consensus guidelines, if eosinophilic esophagitis (EoE) is suspected, not only esophageal but also gastric and duodenal biopsy specimens should be sampled in order to exclude other generalized or eosinophilic gastrointestinal (GI) disorders, such as eosinophilic gastroenteritis or celiac disease. However, the diagnostic yield for this remains unclear.

Aim: To assess the diagnostic yield of biopsy sampling from the stomach and duodenum in adult EoE patients to rule out generalized or eosinophilic GI disorders. Read More

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A Rare Case of Eosinophilic Gastroenteritis and Ampullitis Leading to Benign Papillary Stenosis.

Case Rep Gastrointest Med 2021 9;2021:5597578. Epub 2021 Mar 9.

Icahn School of Medicine at Mount Sinai (NYC Health+Hospitals/Queens) Program, New York City, NY, USA.

Eosinophilic gastroenteritis is characterized by eosinophilic infiltration of the gastrointestinal wall. There have been limited studies of eosinophilic infiltration involving the ampulla. We present a 70-year-old woman with a history of asthma, eosinophilic esophagitis, and eosinophilic sinusitis, who underwent work up for postprandial abdominal pain and abnormal liver function tests. Read More

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Small-bowel Capsule Endoscopic Features in Patients with Eosinophilic Gastroenteritis: Three Case Reports.

Intern Med 2021 Mar 29. Epub 2021 Mar 29.

Department of Gastroenterology, Faculty of Medicine, Yamagata University, Japan.

Eosinophilic gastroenteritis (EGE) is an uncommon disease characterized by eosinophilic infiltration of the gastrointestinal tract in the absence of secondary causes and presents with a variety of gastrointestinal manifestations. Important diagnostic evidence for EGE can be provided by endoscopy; however, the specific small-bowel capsule endoscopic (SBCE) findings remain unknown. We herein report the SBCE findings of three cases of EGE as well as those of the previous cases. Read More

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Rare case of rapidly reaccumulating ascites.

BMJ Case Rep 2021 Mar 10;14(3). Epub 2021 Mar 10.

Internal Medicine, Rutgers New Jersey Medical School, Newark, New Jersey, USA.

Eosinophilic ascites is a rare type of exudative ascites most commonly caused by eosinophilic gastroenteritis. Here, a 57-year-old man presents with sudden-onset abdominal distension associated with nausea, vomiting and decreased appetite for 10 days. Physical examination revealed significant abdominal distention and fluid wave. Read More

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Diagnostic approach to small-bowel wall thickening: beyond Crohn's disease and cancer.

Radiologia (Engl Ed) 2021 Feb 2. Epub 2021 Feb 2.

Servicio de Radiodiagnóstico, Hospital Universitario Marqués de Valdecilla, Santander, España.

Although small-bowel wall thickening is a common manifestation of Crohn's disease and tumors, many other entities can give rise to similar imaging findings. The small bowel is difficult to access by endoscopy, so radiologic imaging tests play an essential role in the diagnosis of conditions involving the small bowel. The main objectives of this paper are to explain the definition of small-bowel wall thickening, analyze the patterns of involvement seen in multidetector computed tomography (MDCT) with intravenous contrast administration, and provide an image-based review of the different causes of small-bowel wall thickening. Read More

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February 2021

Eosinophilic gastroenteritis in an adolescent male with history of chronic bullous disease.

BMJ Case Rep 2021 Feb 4;14(2). Epub 2021 Feb 4.

Division of Allergy and Immunology - Department of Pediatrics, Philippine General Hospital, Manila, Philippines.

Eosinophilic gastroenteritis is a rare inflammatory disorder of the gastrointestinal tract. Although commonly associated with allergic diseases, it is also rarely associated with autoimmune disorders. This case report describes a 17-year-old Filipino male with eosinophilic gastroenteritis, manifesting as abdominal pain, vomiting and diarrhoea. Read More

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February 2021

Vitamin D deficiency causing eosinophilic esophagogastroenteritis and ascites: a rare association.

BMJ Case Rep 2021 Feb 4;14(2). Epub 2021 Feb 4.

Medicine, University of Malaya, Kuala Lumpur, Malaysia

A 54-year-old Chinese man presented with ascites for 2 weeks. He had a preceding 2-year history of intermittent dysphagia, lethargy and general malaise. Blood investigations revealed leucocytosis with eosinophilia of 26. Read More

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February 2021

Two Cases of Eosinophilic Gastroenteritis With Rare Manifestations Revealed in Medical Checkup Findings.

Cureus 2020 Dec 17;12(12):e12118. Epub 2020 Dec 17.

Department of Gastroenterology, Shimane University Hospital, Izumo, JPN.

Eosinophilic gastroenteritis (EGE) is characterized by dense infiltration of eosinophils in gastrointestinal tissues, resulting in morphological and functional abnormalities of the gastrointestinal tract. EGE susceptibility is most common among individuals aged 40-50 years old, and hence it is likely that affected patients will be encountered at the time of a medical checkup. In this report, we present two rare cases of EGE that presented interesting manifestations in findings obtained in a fluoroscopic examination performed at an annual medical checkup. Read More

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December 2020

Experimental Modeling of Eosinophil-Associated Diseases.

Methods Mol Biol 2021 ;2241:275-291

John W. Deming Department of Medicine, Section of Pulmonary Diseases, Tulane Eosinophilic Disorder Center (TEDC), Tulane University School of Medicine, New Orleans, LA, USA.

Eosinophils are an important subtype of leukocytes derived from bone marrow multipotent hematopoietic stem cells and represent about 1% of leukocytes in circulating blood. In homeostatic conditions, eosinophils reside in the intestine to maintain the balance of immune responses by communicating with gut microbes without causing inflammation. However, under the stressed or diseased condition, eosinophils degranulate, releasing their granule-derived cytotoxic proteins that are involved in inflammatory responses. Read More

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Hyper-eosinophilic syndrome: An uncommon cause of chronic abdominal pain in an elderly male.

Trop Doct 2021 Jan 20:49475520987765. Epub 2021 Jan 20.

Senior Resident, Department of Gastroenterology and Hepatology, 90946Kalinga Institute of Medical Sciences, Bhubaneswar, Odisha, India.

Hypereosinophilia is defined as an absolute eosinophil count of ≥1.5 × 10/L, and its presence with involvement of at least one organ system defines the hypereosinophilic syndrome. It may occur with parasitic infestation, connective tissue disorder or rarely in clonal disorders such as eosinophilic leucaemia. Read More

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January 2021

Non-IgE- or Mixed IgE/Non-IgE-Mediated Gastrointestinal Food Allergies in the First Years of Life: Old and New Tools for Diagnosis.

Nutrients 2021 Jan 14;13(1). Epub 2021 Jan 14.

Food Allergy Committee of the Italian Society of Pediatric Allergy and Immunology (SIAIP), Pediatric Department, Garbagnate Milanese Hospital, ASST Rhodense, 70056 Garbagnate Milanese, Italy.

non-IgE and mixed gastrointestinal food allergies present various specific, well-characterized clinical pictures such as food protein-induced allergic proctocolitis, food protein-induced enterocolitis and food protein-induced enteropathy syndrome as well as eosinophilic gastrointestinal disorders such as eosinophilic esophagitis, allergic eosinophilic gastroenteritis and eosinophilic colitis. The aim of this article is to provide an updated review of their different clinical presentations, to suggest a correct approach to their diagnosis and to discuss the usefulness of both old and new diagnostic tools, including fecal biomarkers, atopy patch tests, endoscopy, specific IgG and IgG4 testing, allergen-specific lymphocyte stimulation test (ALST) and clinical score (CoMiss). Read More

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January 2021

Diagnostic Delay in Patients with Eosinophilic Gastritis and/or Duodenitis: A Population-Based Study.

J Allergy Clin Immunol Pract 2021 05 10;9(5):2050-2059.e20. Epub 2021 Jan 10.

Allakos Inc., Redwood City, Calif.

Background: Eosinophilic gastritis and/or eosinophilic duodenitis (EG/EoD) is characterized by persistent symptoms and elevated eosinophils in the gastrointestinal tract. Limited disease awareness and lack of diagnostic guidelines suggest that patients may remain undiagnosed or endure diagnostic delay.

Objective: To characterize the path to diagnosis for patients with EG/EoD in a representative population. Read More

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A case with eosinophilic gastroenteritis exhibiting enhanced TNF-α and IL-6 responses.

Clin J Gastroenterol 2021 Apr 5;14(2):511-516. Epub 2021 Jan 5.

Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka, 589-8511, Japan.

Eosinophilic gastroenteritis (EGE) is a chronic allergic disorder characterized by infiltration of eosinophils in the gastrointestinal (GI) tract and hypereosinophilia. Although T helper type 2 (Th2) responses play pathogenic roles in EGE, roles of innate immunity cytokines including IL-6 and TNF-α have been poorly defined. Here, we describe a case of EGE exhibiting accumulation of eosinophils in the upper GI mucosa and hypereosinophilia. Read More

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A case report of eosinophilic gastroenteritis misdiagnosed as cholelithiasis.

Clin Case Rep 2020 Dec 7;8(12):2843-2847. Epub 2020 Sep 7.

The Department of Radiology Suining Central Hospital Sichuan China.

Eosinophilic gastroenteritis is not only easy to ignore in clinical practice, but also easy to miss in the process of pathological diagnosis. There is a need to consider it in the differential diagnosis of alimentary disease. Read More

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December 2020

Eosinophilic Ascites: A Rare Case Report With Diagnostic and Therapeutic Challenges.

Cureus 2020 Nov 6;12(11):e11362. Epub 2020 Nov 6.

General Medicine, All India Institute of Medical Sciences, Bhubaneswar, IND.

Eosinophilic ascites is a manifestation of serosal eosinophilic gastrointestinal disease. We present a 44-year-old male with low serum ascites albumin gradient with high eosinophil count and contrast-enhanced computed tomography of the abdomen showing circumferential wall thickening of the esophagus, mid to distal ileal loops, and ascending colon. The patient was managed with tablet prednisolone 20 mg twice daily for two weeks, then gradual tapering over one month. Read More

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November 2020

Endoscopic findings of gastric lesions in patients with eosinophilic gastrointestinal disorders.

Endosc Int Open 2020 Dec 17;8(12):E1817-E1825. Epub 2020 Nov 17.

Department of Diagnostic Pathology, Osaka City University Graduate School of Medicine, Osaka, Japan.

 Eosinophilic gastrointestinal disorders are classified into eosinophilic esophagitis, eosinophilic gastritis, eosinophilic gastroenteritis, and eosinophilic colitis according to the site of eosinophilic infiltration. Although well established in eosinophilic esophagitis, endoscopic findings in eosinophilic gastritis and eosinophilic gastroenteritis with regard to gastric lesions have not been clearly described. The aim of this study was to identify endoscopic findings of gastric lesions associated with eosinophilic gastrointestinal disorders. Read More

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December 2020

Clinical Characteristics and Treatment Outcomes of Patients with Eosinophilic Esophagitis and Eosinophilic Gastroenteritis.

Digestion 2021 17;102(1):33-40. Epub 2020 Nov 17.

Second Department of Internal Medicine, Shimane University Faculty of Medicine, Izumo, Japan.

Background: Eosinophilic esophagitis (EoE) and eosinophilic gastroenteritis (EGE), part of the spectrum of eosinophilic gastrointestinal disorders (EGID), share pathogenic similarities. We examined differences regarding clinical characteristics and treatment outcomes between EoE and EGE cases.

Methods: Two-hundred fifteen EGID patients, including 181 with EoE and 34 with EGE, diagnosed at Shimane University Hospital between February 2011 and March 2019 were enrolled. Read More

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November 2020

Anti-Siglec-8 Antibody for Eosinophilic Gastritis and Duodenitis.

N Engl J Med 2020 10;383(17):1624-1634

From the University of North Carolina, Chapel Hill (E.S.D.); the University of Utah, Salt Lake City (K.A.P.); Mayo Clinic Rochester, Rochester, MN (J.A.M., A.C.B.); the University of Pennsylvania Perelman School of Medicine, Philadelphia (G.W.F.); Northwestern University, Chicago (N.G., I.H.); the Icahn School of Medicine at Mount Sinai, New York (M.C.); Baylor College of Medicine, Houston (R.M.G.); Tufts University, Boston (J.L.); the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD (P.K., A.D.K.); Ventura Clinical Trials, Ventura (S.H.), and Allakos, Redwood City (C.S., A.T.C., B.S., A.P.K., H.S.R.) - both in California; Vanderbilt University, Nashville (M.V.); the Division of Allergy and Immunology, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati (S.R.D., M.E.R.); and Pharma Data Associates, Piscataway, NJ (C.W.).

Background: Eosinophilic gastritis and duodenitis are characterized by gastrointestinal mucosal eosinophilia, chronic symptoms, impaired quality of life, and a lack of adequate treatments. Mast-cell activity may contribute to the pathogenesis of the conditions. AK002 (lirentelimab) is an anti-Siglec-8 antibody that depletes eosinophils and inhibits mast cells and that has shown potential in animal models as a treatment for eosinophilic gastritis and duodenitis. Read More

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October 2020

Eosinophilic gastroenteritis with gastric perforation-An unusual presentation.

Indian J Gastroenterol 2020 12;39(6):624-626

Department of Clinical Research, Surat Institute of Digestive Sciences, Majura Gate, Ring Road, Surat, 395 002, India.

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December 2020

Disease Course and Treatment Response of Eosinophilic Gastrointestinal Diseases in Children With Liver Transplantation: Long-Term Follow-Up.

Am J Gastroenterol 2021 01;116(1):188-197

Department of Pediatric Gastroenterology, Hepatology and Nutrition, Koc University School of Medicine, Istanbul, Turkey.

Introduction: To describe the clinical and laboratory profile, natural course, treatment outcome, and risk factors of posttransplant esophageal and nonesophageal eosinophilic gastrointestinal disorders (EGIDs).

Methods: All children (aged <18 years) who underwent liver transplantation, between 2011 and 2019, in a single transplant center with a follow-up period of 1 year or more posttransplant and with a history of posttransplant endoscopic evaluation were included in this study.

Results: During the study period, 89 children met the inclusion criteria. Read More

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January 2021

Eosinophilic gastroenteritis as a cause of gastrointestinal tract bleeding and protein-losing enteropathy.

Turk Pediatri Ars 2020 23;55(3):299-303. Epub 2020 Sep 23.

Division of Pediatric Gastroenterology and Hepatology, Eskişehir Osmangazi University Faculty of Medicine, Eskişehir, Turkey.

Eosinophilic gastroenteritis is an inflammatory disease characterized by pathologic eosinophilic infiltration of any portion of the gastrointestinal tract. Depending on the involved site and layer of eosinophilic infiltration, symptoms and signs are heterogeneous. This manuscript reports two patients who presented with acute upper gastrointestinal tract bleeding and protein-losing enteropathy signs, and were diagnosed as having eosinophilic gastroenteritis. Read More

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September 2020

Eosinophilic gastroenteritis: One entity with different clinical manifestations.

Gastroenterol Hepatol 2021 May 25;44(5):384-385. Epub 2020 Sep 25.

Servicio de Medicina Digestiva, Hospital Universitari i Politècnic La Fe, Valencia, España.

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Eosinophilic colitis: an infrequent disease with difficult diagnose.

BMJ Case Rep 2020 Sep 21;13(9). Epub 2020 Sep 21.

Department of General and Digestive Surgery, Hospital Universitario de Móstoles, Móstoles, Spain.

Eosinophilic colitis (EC) is a rare entity. It is part of eosinophilic gastroenteritis, a rare inflammatory disorder characterised by eosinophilic infiltration of tissues that can affect any segment of the digestive tract. The diagnosis is established by the presence of an increased eosinophilic infiltrate in the colon wall in symptomatic patients. Read More

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September 2020

Halo sign and araneid limb-like sign in eosinophilic enteritis.

Lancet Gastroenterol Hepatol 2020 10;5(10):954

First Department of General Surgery (Department of Colorectal and Anal Surgery), Hunan Provincial People's Hospital (First Affiliated Hospital of Hunan Normal University), Changsha, Hunan, China.

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October 2020

Eosinophilic Gastroenteritis with a Relapsing and Remitting Course with Presence of Autoimmune Antibodies.

Case Rep Med 2020 18;2020:1745834. Epub 2020 Aug 18.

Faculty of Medicine, University of Ruhuna, Matara, Sri Lanka.

Background: Eosinophilic gastroenteritis (EGE) is an uncommon disease characterized by eosinophilic infiltration of the digestive tract, which occurs due to an uncertain aetiology. Although autoimmune diseases can later present as EGE, it is unusual for EGE to have positive autoimmune antibodies without the presence of an overt autoimmune disease. We report a 38-year-old previously healthy man who presented with abdominal discomfort and loose stools with pleural and peritoneal effusions progressing over several weeks. Read More

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