989 results match your criteria Eosinophilic Gastroenteritis


Eosinophilic gastroenteritis and graft-versus-host disease induced by transmission of Norovirus with fecal microbiota transplant.

Transpl Infect Dis 2020 Jun 23:e13386. Epub 2020 Jun 23.

Department of Hematology, Oncology and Internal Medicine, Medical University of Warsaw, Warsaw, Poland.

Fecal microbiota transplantation (FMT) was performed to decolonize gastrointestinal tract from antibiotic-resistant bacteria before allogeneic hematopoietic cells transplantation (alloHCT). AlloHCT was complicated by Norovirus gastroenteritis, acute graft-versus-host-disease and eosinophilic pancolitis. Norovirus was identified in samples from FMT material. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/tid.13386DOI Listing

Eosinophilic Gastroenteritis-associated Duodenal Ulcer Successfully Treated with Crushed Budesonide.

Intern Med 2020 Jun 15. Epub 2020 Jun 15.

Departments of Gastroenterology, National Hospital Organization Hakodate National Hospital, Japan.

Eosinophilic gastroenteritis (EGE)-associated duodenal ulcer is rare and its endoscopic and pathological features remain poorly described. A 15-year-old boy was referred to our hospital for further examination and treatment of duodenal ulcer. Esophagogastroduodenoscopy (EGD) revealed two A2-stage duodenal ulcers on the duodenal bulb. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2169/internalmedicine.4706-20DOI Listing

[EOSINOPHILIC GASTROINTESTINAL DISORDERS (EGIDs)].

Authors:
Yoshiyuki Yamada

Arerugi 2020;69(4):260-266

Gunma Children's Medical Center.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15036/arerugi.69.260DOI Listing
January 2020

Nationwide Multicenter Study of Eosinophilic Esophagitis in Korean Children.

Pediatr Gastroenterol Hepatol Nutr 2020 May 8;23(3):231-242. Epub 2020 May 8.

Department of Pediatrics, Seoul National University Bundang Hospital, Sungnam, Korea.

Purpose: In East Asian countries, there are only a few epidemiologic studies of eosinophilic esophagitis (EoE) and no studies in children. We investigated the incidence and compared the clinical characteristics of EoE and eosinophilic gastroenteritis involving the esophagus (EGEIE) in Korean children.

Methods: A total of 910 children, who had symptoms of esophageal dysfunction, from 10 hospitals in Korea were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5223/pghn.2020.23.3.231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231742PMC

Eosinophilic gastroenteritis in small intestine in a child in a remote medical centre required surgery.

Int J Surg Case Rep 2020 25;71:209-212. Epub 2020 May 25.

General Surgery Department, Alhekma Hospital, Aleppo, Syria.

Introduction: Eosinophilic gastroenteritis (EGE) is an extremely rare disease of unknown aetiology that can occur at any age, but rarely in children. It usually presents with ambiguous abdominal pain and the symptoms can occur for years before diagnosis. It needs a high suspicion and therefore misdiagnosis can occur. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijscr.2020.05.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262374PMC

Targeted Therapies for Eosinophilic Gastrointestinal Disorders.

BioDrugs 2020 May 29. Epub 2020 May 29.

Division of Hospital Pharmacy, Hospital General de Tomelloso, Tomelloso, Spain.

The growing recognition of eosinophilic gastrointestinal disorders has revealed the limitations of current treatment (mainly based on dietary modification and corticosteroids), and include refractoriness, high recurrence rates, and the need for long-term therapy. Research efforts, mainly in eosinophilic esophagitis (EoE), have unveiled essential pathophysiological mechanisms leading to these disorders, which bear some similarities to those of atopic manifestations and are shared by eosinophilic gastroenteritis (EGE) and eosinophilic colitis (EC). Novel targeted therapies, some imported from bronchial asthma and atopic dermatitis, are currently being assessed in EoE. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40259-020-00427-wDOI Listing

Conversion from tacrolimus to sirolimus as a treatment modality in de novo allergies and immune-mediated disorders in pediatric liver transplant recipients.

Pediatr Transplant 2020 May 19:e13737. Epub 2020 May 19.

Division of Gastroenterology, Hepatology, and Nutrition, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

De novo PTAID may develop in pediatric solid organ transplant recipients, have a diverse spectrum, and are occasionally treatment resistant. Previous reports showed resolution of immune cytopenias in solid organ transplant recipients following replacement of the calcineurin inhibitor tacrolimus with the mTOR inhibitor sirolimus. Herein we describe a retrospective review (2000-2017) of subjects who developed PTAID in whom immunosuppression was changed to sirolimus. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/petr.13737DOI Listing

Single-Organ and Multisystem Hypereosinophilic Syndrome Patients with Gastrointestinal Manifestations Share Common Characteristics.

J Allergy Clin Immunol Pract 2020 Apr 25. Epub 2020 Apr 25.

Laboratory of Parasitic Diseases, NIAID, Bethesda, Md.

Background: Eosinophilic gastrointestinal diseases (EGIDs) are defined by marked eosinophilia in the gastrointestinal (GI) tract resulting in a wide variety of GI symptoms. When accompanied by blood hypereosinophilia (HE; absolute eosinophil count ≥1500/mm), EGID can occur as an isolated GI disorder (hypereosinophilic syndrome [HES]/EGID overlap) or as part of a multisystem hypereosinophilic syndrome (Multisystem HES).

Objective: To describe the GI disease of patients categorized as those with HES/EGID overlap versus those with Multisystem HES. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaip.2020.04.025DOI Listing

Severe eosinophilic asthma and aspirin-exacerbated respiratory disease associated to eosinophilic gastroenteritis treated with mepolizumab: a case report.

Allergy Asthma Clin Immunol 2020 22;16:27. Epub 2020 Apr 22.

3IBD UNIT Presidio Columbus, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Background: Mepolizumab (MEP) is the first anti Interleukin (IL)-5 add-on therapy approved for the treatment of severe refractory eosinophilic asthma.

Case Presentation: We describe here the case of a 49 years-old woman with Aspirin-exacerbated respiratory disease (AERD), chronic rhinosinusitis, nasal polyposis and eosinophilic gastroenteritis successfully treated with MEP. Several laboratory and clinical items improved during therapy; moreover MEP showed to be useful as steroid sparing agent. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13223-020-00423-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178951PMC

Eosinophilic gastroenteritis with multiple serous membrane effusion as the first sign: a case report and literature review.

J Int Med Res 2020 Apr;48(4):300060520917274

Department of Digestive Disease, The First People's Hospital of Changzhou, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0300060520917274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180310PMC

Upper Gastrointestinal Bleed in a Young Male- A Rare Presentation of Eosinophilic Gastroenteritis.

Cureus 2020 Feb 20;12(2):e7059. Epub 2020 Feb 20.

Internal Medicine, Avnentura Hosptial and Medical Center, Aventura, USA.

Eosinophilic gastroenteritis (EGE) is a rare idiopathic disease affecting multiple organs (stomach and small intestine) of the digestive tract. It is characterized by eosinophilic infiltration of the bowel wall to a variable depth and symptoms associated with gastrointestinal tract disease. The prevalence of this condition is ranging from 8 and 28 per 100,000. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.7059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086115PMC
February 2020

Eosinophilic pancreatitis: a rare or unexplored disease entity?

Prz Gastroenterol 2020 3;15(1):34-38. Epub 2020 Mar 3.

Department of Medicine, Section of Pulmonary Diseases, Tulane Eosinophilic Disorders Centre, Tulane University School of Medicine, New Orleans, LA, USA.

Several case reports show accumulation of eosinophils in pancreatitis patients and term the disease as "eosinophilic pancreatitis (EP)". EP usually presents with a pancreatic tumour and abdominal pain in obstructive jaundice, which is generally not diagnosed until the patient undergoes pancreatic resection. Histologically, EP reveals distinct patterns like diffused, periductal, acinar, and septal inflammatory infiltrates with eosinophils, eosinophilic phlebitis, and localised extreme eosinophilic infiltrates related with pseudocyst formation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5114/pg.2019.90631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089860PMC
March 2020
0.375 Impact Factor

Eosinophilic gastroenteritis in pregnancy: A review of the literature.

Eur J Obstet Gynecol Reprod Biol 2020 May 6;248:102-105. Epub 2020 Mar 6.

Department of Translational Medicine, University of Eastern Piedmont, Via Solaroli 17, 28100, Novara, Italy.

Eosinophilic gastroenteritis (EGE) is an uncommon and heterogeneous disease characterized by eosinophilic infiltration of the gastrointestinal tract. There are very few reports in literature describing pregnancies in EGE patients, and no review has ever been published. We found a total of 12 cases including one that occurred in our clinic. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejogrb.2020.03.002DOI Listing

[A CASE OF EOSINOPHILIC GASTROENTERITIS FOUND BY PICA DURING ORAL IMMUNOTHERAPY].

Arerugi 2020 ;69(2):123-128

Allergy Center, National Center for Child Health and Development.

Eosinophilic esophagitis has been reported as a complication of oral immunotherapy (OIT), but there are only a few reports of eosinophilic gastroenteritis (EGE) occurring after OIT. EGE causes eosinophil infiltration into the gastrointestinal (GI) tract and is characterized by various digestive symptoms. We report the case of a 6-year-old boy with EGE. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15036/arerugi.69.123DOI Listing

Ascites: an unusual presentation of eosinophilic gastroenteritis in a child.

Trop Doct 2020 Mar 16:49475520911230. Epub 2020 Mar 16.

Professor and Head, Division of Paediatric Gastroenterology, Post Graduate Institute of Medical Education & Research, Chandigarh, India.

Eosinophilic ascites, owing to serosal involvement, is a very rare manifestation of eosinophilic gastroenteritis in children, especially when it occurs with muscular involvement in the absence of mucosal disease, which may be confirmed by endoscopic ultrasonography. An 11-year-old girl, presenting with massive eosinophilic ascites and colicky abdominal pain with peripheral eosinophilia, raised IgE levels and positive skin prick test, had such investigation which confirmed the presence of muscle layer thickening of both stomach and small bowel. She responded well to steroids and montelukast. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0049475520911230DOI Listing

Multiple ulcerations and perforation in the small intestine after steroid treatment in eosinophilic granulomatosis with polyangiitis: a case report and literature review.

Cardiovasc Pathol 2020 Jul - Aug;47:107193. Epub 2019 Dec 18.

Department of Cellular and Organ Pathology, Graduate School of Medicine, Akita University, Akita, Japan.

Eosinophilic granulomatosis with polyangiitis (EGPA), formerly called Churg-Strauss syndrome, is an uncommon disease with pathological features consisting of systemic necrotizing vasculitis, eosinophilic infiltration, and granulomatous or nongranulomatous extravascular eosinophilic inflammation. EGPA preferentially affects certain organ systems, including the airways, peripheral nerves, heart, kidney, and gastrointestinal tract. Although gastrointestinal involvement, such as ulcerations, is common in EGPA, gastrointestinal perforation is relatively uncommon and is associated with a poor prognosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.carpath.2019.107193DOI Listing
December 2019

Eosinophils, a Jack of All Trades in Immunity: Therapeutic Approaches for Correcting their Functional Disorders.

Endocr Metab Immune Disord Drug Targets 2020 03 8. Epub 2020 Mar 8.

Department of Basic Medical Sciences, Neuroscience and Sensory Organs, School of Medicine, University of Bari “Aldo Moro”, Bari, Italy

Background: Eosinophils are primitive myeloid cells which derive from bone-marrow precursors and require the intervention of interleukin (IL)-5 for their survival and persistence in blood and tissues. Under steady state conditions, they contribute to immune regulation and homeostasis. Under pathological circumstances, eosinophils are involved in both host protection against parasites and participation to allergy and inflammation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1871530320666200309094726DOI Listing

Efficacy of a Short-term Six-food Elimination Diet and Reintroduction Therapy in Pediatric Eosinophilic Gastroenteritis.

Intern Med 2020 Jun 26;59(11):1379-1385. Epub 2020 Feb 26.

Department of Pediatrics, Faculty of Medicine, Saga University, Japan.

A 13-year-old boy presented to the hospital with a 3-month history of repeated vomiting and abdominal pain. Results of esophagogastroduodenoscopy revealed a diagnosis of eosinophilic gastroenteritis (EGE). We initiated a short-term six-food elimination diet (SFED) and reintroduction therapy over five days. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2169/internalmedicine.4264-19DOI Listing

Mural Eosinophilic Gastrointestinal Disease in 2 Pediatric Patients Presenting as Focal Mass.

Pediatrics 2020 03 19;145(3). Epub 2020 Feb 19.

Divisions of Gastroenterology, Hepatology and Nutrition and.

Eosinophilic gastrointestinal diseases (EGIDs) are a diverse group of intestinal diseases involving the infiltration of eosinophils into the bowel wall. EGID can present with a variety of clinical conditions, which are largely dependent on the location of eosinophils in the intestinal wall. We describe the first reported pediatric cases of EGID presenting with symptomatic partial bowel obstruction from intestinal masses due to isolated focal mural involvement. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1542/peds.2019-1610DOI Listing

Eosinophilic gastroenteritis: epidemiology, diagnosis, and treatment.

Curr Opin Allergy Clin Immunol 2020 Jun;20(3):311-315

Department of Gastroenterology, Shimane University School of Medicine, Izumo, Japan.

Purpose Of Review: Although several reviews concerning diagnosis and treatment of eosinophilic esophagitis (EoE) have been presented, there are few in regard to eosinophilic gastroenteritis (EGE). Fortunately, findings related to epidemiology, as well as diagnosis and treatment of this disease have recently been increasing.

Recent Findings: The rates of incidence of both EoE and EGE have been reported to be increasing. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/ACI.0000000000000635DOI Listing

An Uncommon Cause of Acute Gastroenteritis, Intestinal Obstruction and Ascites.

Authors:
Huahong Xie

Gastroenterology 2020 Feb 1. Epub 2020 Feb 1.

State key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Air Force Military Medical University/ Fourth Military Medical University, Xi'an, 710032, Shaanxi Province, P. R. China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2020.01.037DOI Listing
February 2020

Eosinophilic esophagitis and other eosinophilic disorders of the gastrointestinal tract.

Pediatr Allergy Immunol 2020 02;31 Suppl 24:25-27

Pediatrics Department, Perlman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Eosinophilic disorders of the gastrointestinal tract (EGID) are a group of diseases characterized by an eosinophilic inflammation limited to the GI tract. EoE is by far the most common EGID and is an atopic chronic/relapsing eosinophilic inflammation of the esophagus. It is now recognized as an increasingly common cause of esophageal dysfunction, fibrosis, stricture, and food impaction in children and adults. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pai.13153DOI Listing
February 2020

Eosinophilic gastroenteritis with persistent abdominal pain: a case report.

J Rural Med 2020 Jan 23;15(1):44-46. Epub 2020 Jan 23.

Department of Pediatrics, Abashiri-Kosei General Hospital, Japan.

Two months ago, a 9-year-old boy experienced intermittent abdominal pain regardless of food intake, without diarrhea, bloody stool, or nausea. Blood test results revealed a peripheral blood eosinophil count of 660 cells /µL, which was marginally elevated, without inflammatory reaction, occult blood, or enteric pathogens. The intestinal mucosa from the terminal ileum to the rectum was endoscopically normal, but mucosal biopsy revealed eosinophilic infiltration of the terminal ileum and whole colon with ≥20 eosinophils/high power field (HPF). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2185/jrm.2019-009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983457PMC
January 2020

Eosinophilic gastroenteritis developed after remission of cow's milk allergy.

Pediatr Int 2020 Feb 3;62(2):233-234. Epub 2020 Feb 3.

Department of Pediatrics, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ped.14078DOI Listing
February 2020

Neonatal eosinophilic gastroenteritis mimicking hypertrophic pyloric stenosis.

Pediatr Int 2020 Jan;62(1):99-101

Department of Pediatrics, Japanese Red Cross Society, Wakayama Medical Center, Wakayama, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ped.14041DOI Listing
January 2020

Eosinophilic ascites: an unusual manifestation of eosinophilic gastroenteritis.

Int J Colorectal Dis 2020 Apr 27;35(4):765-767. Epub 2020 Jan 27.

Department of Gastroenterology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.

Introduction: Eosinophilic gastroenteritis is an uncommon disorder, characterized by eosinophilic infiltration of the gastrointestinal tract. Clinical presentations are variable. It depends on the involvement of GI layer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00384-020-03510-4DOI Listing

A man with abdominal pain and eosinophilia : tissue is the issue.

Acta Gastroenterol Belg 2019 Oct-Dec;82(4):532-535

Department of Gastro-enterology AZ Sint Lucas, Ghent, Belgium.

A 24-year-old male presented with abdominal pain, postprandial vomiting and weight loss. Lab results showed an elevated serum eosinophil count and CT-scan demonstrated a thickened antral, duodenal and jejunal wall. Repetitive endoscopic mucosal biopsies were normal. Read More

View Article

Download full-text PDF

Source
February 2020

Eosinophilic gastroenteritis presenting as achalasia cardia and responding to botulinum injection and therapy directed against eosinophilic esophagitis.

Indian J Gastroenterol 2019 12;38(6):554-556

Departments of Gastroenterology and Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, 226 014, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12664-019-01012-yDOI Listing
December 2019

Eosinophilic Granulomatosis with Polyangiitis Initially Diagnosed as Eosinophilic Gastroenteritis.

Intern Med 2020 Apr 26;59(8):1029-1033. Epub 2019 Dec 26.

Department of Internal Medicine II, Shimane University Faculty of Medicine, Japan.

We herein report two cases of eosinophilic granulomatosis with polyangiitis (EGPA) initially diagnosed as eosinophilic gastroenteritis (EGE) based solely on endoscopic biopsy results. One year after the EGE diagnosis, one patient presented with multiple purpura, and skin biopsy findings resulted in a change of the diagnosis to EGPA. In another patient, multiple skin and colonic ulcerations emerged eight years after the diagnosis of EGE, at which time histological examinations of endoscopic biopsy specimens revealed vasculitis, and the diagnosis was changed to EGPA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2169/internalmedicine.3391-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205524PMC

Approaches and Challenges to Management of Pediatric and Adult Patients With Eosinophilic Esophagitis.

Gastroenterology 2020 03 10;158(4):840-851. Epub 2019 Dec 10.

Digestive Health Institute, Children's Hospital Colorado, Gastrointestinal Eosinophilic Diseases Program, University of Colorado School of Medicine, Aurora, Colorado.

Treatment of eosinophilic esophagitis has progressed from elemental formula for children and esophageal dilation for adults to selective exclusion of food triggers and swallowed topical corticosteroids. Management guidelines are available from the American Gastroenterological Association and the Joint Task Force on Allergy Immunology Practice Parameters. We cannot, however, evaluate the efficacy of treatments without a definition of response. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2019.09.052DOI Listing

Future therapies for eosinophilic gastrointestinal disorders.

Ann Allergy Asthma Immunol 2020 03 26;124(3):219-226. Epub 2019 Nov 26.

Division of Pediatric Gastroenterology, Hepatology and Nutrition, Children's Hospital of Illinois and the University of Illinois College of Medicine, Peoria, Illinois. Electronic address:

Objective: To review novel therapeutics in development for treatment of eosinophilic gastrointestinal disorders (EGIDs).

Data Sources: Clinical trial data (clinicaltrials.gov) and literature search on PubMed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.anai.2019.11.018DOI Listing

Association Between Endoscopic and Histologic Findings in a Multicenter Retrospective Cohort of Patients with Non-esophageal Eosinophilic Gastrointestinal Disorders.

Dig Dis Sci 2020 Jul 26;65(7):2024-2035. Epub 2019 Nov 26.

Center for Esophageal Diseases and Swallowing and Center for Gastrointestinal Biology and Disease, Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina School of Medicine, CB #7080, Chapel Hill, NC, 27599, USA.

Background: Little is known about the endoscopic and histologic findings of non-esophageal eosinophilic gastrointestinal diseases (EGID).

Aim: To characterize the presenting endoscopic and histologic findings in patients with eosinophilic gastritis (EG), eosinophilic gastroenteritis (EGE), and eosinophilic colitis (EC) at diagnosis and 6 months after initiating the treatment.

Methods: We conducted a retrospective cohort study at 6 US centers associated with the Consortium of Eosinophilic Gastrointestinal Researchers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10620-019-05961-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315780PMC

Dual checkpoint inhibitor-associated eosinophilic enteritis.

J Immunother Cancer 2019 11 15;7(1):310. Epub 2019 Nov 15.

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Background: Eosinophilia has been reported as a rare, new biological effect of immune checkpoint inhibition that may be associated with improved treatment response and the development of immune-related adverse events.

Case Presentation: We report a case of dual checkpoint inhibitor-associated hypereosinophilia and eosinophilic enteritis in a patient with advanced cutaneous melanoma. Rapid resolution of peripheral eosinophilia and associated symptoms was achieved with steroids alone. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40425-019-0743-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858706PMC
November 2019

Complex Muco-cutaneous Manifestations of CARMIL2-associated Combined Immunodeficiency: A Novel Presentation of Dysfunctional Epithelial Barriers.

Acta Derm Venereol 2020 Jan 23;100(1):adv00038. Epub 2020 Jan 23.

Institute of Genomic Medicine, F. Policlinico Gemelli IRCCS, Università Cattolica del Sacro Cuore, Largo F. Vito 1, IT-00168 Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2340/00015555-3370DOI Listing
January 2020

Eosinophilic gastrointestinal disease below the belt.

J Allergy Clin Immunol 2020 Jan 24;145(1):87-89.e1. Epub 2019 Oct 24.

Division of Allergy/Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2019.10.013DOI Listing
January 2020
5 Reads

Eosinophilic Gastrointestinal Diseases in Children: A Practical Review

Curr Pediatr Rev 2019 10 22. Epub 2019 Oct 22.

Department of Pediatrics, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia. Italy.

Primary eosinophilic gastrointestinal diseases (EGIDs) represent a heterogeneous group of disorders characterized by eosinophilic inflammation in the absence of known causes for eosinophilia, selectively affecting different segments of the gastrointestinal tract. While pediatric eosinophilic esophagitis (EoE) is a well-defined disease with established guidelines, Eosinophilic Gastritis (EoG), Eosinophilic Gastroenteritis (EoGE) and Eosinophilic Colitis (EoC) remain a clinical enigma with evidence based on limited anecdotal case reports. Large cross-sectional studies in the US defined a prevalence of EoG and EoGE ranging from 1,5 to 6,4/100. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1573396315666191022154432DOI Listing
October 2019
9 Reads

An Autopsy Case of a 5-Year-Old Child with Acute Pancreatitis Caused by Eosinophilic Granulomatosis with Polyangiitis-like Necrotizing Vasculitis.

Case Rep Rheumatol 2019 2;2019:9053747. Epub 2019 Sep 2.

Department of Diagnostic Pathology, Seirei Mikatahara Hospital, 3453 Mikataharacho, Hamamatsu 433-8558, Japan.

In children, acute pancreatitis has been reported in IgA vasculitis, Kawasaki disease, systemic lupus erythematosus-associated vasculitis, and juvenile dermatomyositis-associated vasculitis. However, its frequency in these vasculitides has been shown to be low. In other childhood-onset vasculitides, acute pancreatitis is seldom reported. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2019/9053747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745468PMC
September 2019
5 Reads

Eosinophilic Enteritis Presenting as Massive Ascites after Influenza A Virus Infection in a Young Female.

Korean J Gastroenterol 2019 Sep;74(3):163-167

Division of Gastroenterology, Department of Internal Medicine, CHA University School of Medicine, CHA Gumi Medical Center, Gumi, Korea.

Eosinophilic gastrointestinal disorder (EGID) is an uncommon disease that is accompanied by intestinal eosinophil infiltration without a secondary cause of eosinophilia. Eosinophilic enteritis is a secondary portion of EGID that can present a range of gastrointestinal symptoms according to the affected depth of the intestinal layer. The subserosal type of eosinophilic enteritis presenting as ascites is relatively rarer than the mucosal type. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4166/kjg.2019.74.3.163DOI Listing
September 2019
2 Reads

Eosinophilic gastrointestinal disorders: The journey to diagnosis remains arduous.

Authors:
Mirna Chehade

Ann Allergy Asthma Immunol 2020 03 17;124(3):229-230. Epub 2019 Sep 17.

Mount Sinai Center for Eosinophilic Disorders, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.anai.2019.09.011DOI Listing
March 2020
2 Reads

A rare case of eosinophilic esophagitis and eosinophilic subserosal gastroenteritis with ascites.

Turk J Gastroenterol 2019 09;30(9):851-853

Department of Gastroenterohepatology, Clinic of Internal Medicine, Clinical Center of Montenegro, Podgorica, Montenegro.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5152/tjg.2019.18680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750816PMC
September 2019
1 Read

Evaluation of gene expression change in eosinophilic gastroenteritis.

Gastroenterol Hepatol Bed Bench 2019 ;12(3):239-245

Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Aim: Screening differentially expressed genes (DEGs) related to Eosinophilic gastroenteritis (EG) to introduce possible biomarkers.

Background: EG as a rare gastrointestinal disorder is characterized with gastrointestinal bleeding, crampy generalized abdominal pain, diarrhea, nausea, vomiting, and weight loss. In this study gene expression profile of patients is analysis via protein-protein interaction (PPI) analysis to reveal new prospective of disease. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668767PMC
January 2019
3 Reads

Siglec-8 antibody reduces eosinophils and mast cells in a transgenic mouse model of eosinophilic gastroenteritis.

JCI Insight 2019 10 3;4(19). Epub 2019 Oct 3.

Allakos, Inc., Redwood City, California, USA.

Aberrant accumulation and activation of eosinophils and potentially mast cells (MCs) contribute to the pathogenesis of eosinophilic gastrointestinal diseases (EGIDs), including eosinophilic esophagitis (EoE), gastritis (EG), and gastroenteritis (EGE). Current treatment options, such as diet restriction and corticosteroids, have limited efficacy and are often inappropriate for chronic use. One promising new approach is to deplete eosinophils and inhibit MCs with a monoclonal antibody (mAb) against sialic acid-binding immunoglobulin-like lectin 8 (Siglec-8), an inhibitory receptor selectively expressed on MCs and eosinophils. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/jci.insight.126219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795394PMC
October 2019
3 Reads

[Refractory eosinophilic gastroenteritis with gastritis, duodenal ulcer, and colitis: a case report].

Nihon Shokakibyo Gakkai Zasshi 2019 ;116(8):668-675

First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi.

Eosinophilic gastroenteritis is a rare disease that causes various abdominal symptoms that result from the infiltration of eosinophils in the digestive tract. However, this condition has been poorly explored, and the treatment criteria and prognosis after treatment are still unclear. A 20-year-old man with a refractory duodenal ulcer had been undergoing treatment since 14 years of age at another hospital. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.11405/nisshoshi.116.668DOI Listing
September 2019
6 Reads

Myenteric networks of interstitial cells of Cajal are reduced in horses with inflammatory bowel disease.

Equine Vet J 2020 Mar 5;52(2):298-304. Epub 2019 Sep 5.

Norwegian University of Life Sciences, Oslo, Norway.

Background: Inflammatory bowel disease (IBD) is a well-recognised but poorly understood disease complex in the horse. Clinical signs may vary but often include weight loss, diarrhoea and colic. The effect this disease process may have on the gastrointestinal pacemaker cells (the interstitial cells of Cajal), enteric neurons and glial cells has not been previously evaluated in the horse. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/evj.13160DOI Listing
March 2020
3 Reads

Eosinophilic esophagitis: novel concepts regarding pathogenesis and clinical manifestations.

J Gastroenterol 2019 10 24;54(10):837-844. Epub 2019 Jul 24.

Division of Gastroenterology and Center for Esophageal Diseases, Baylor University Medical Center, 3500 Gaston Avenue, 2 Hoblitzelle, Suite 250, Dallas, TX, 75246, USA.

This report explores two hypotheses regarding eosinophilic esophagitis (EoE): (1) that the use of proton pump inhibitors (PPIs) might contribute to the pathogenesis of EoE by preventing peptic digestion of food allergens, by increasing gastric mucosal permeability to enable gastric absorption of those undegraded food allergens, and by causing microbial dysbiosis, and (2) that EoE, like eosinophilic gastroenteritis, might have mucosal-predominant and muscle-predominant forms, and that the muscle-predominant form of EoE might cause a variety of esophageal motility disorders including achalasia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00535-019-01604-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759606PMC
October 2019
2 Reads

Climbing New Mountains: How Antibodies Blocking α4β7 Integrins Tamed Eosinophilic Inflammation of the Intestinal Tract.

Dig Dis Sci 2019 08;64(8):2068-2071

Department of Pediatrics, Gastrointestinal Eosinophilic Diseases Program, Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado School of Medicine, 12700 East 19th Avenue, Research 2 P15-6026 Mail Stop: C-226, Aurora, CO, 80045, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10620-019-05706-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946547PMC

[Severe Upper Gastrointestinal Bleeding due to Ulcerative Eosinophilic Gastritis in a 79-Year-Old Man].

Dtsch Med Wochenschr 2019 07 28;144(13):893-896. Epub 2019 Jun 28.

Knappschaftskrankenhaus Bottrop, akademisches Lehrkrankenhaus der Universität Duisburg-Essen.

Eosinophilic Gastrointestinal Disease (EGID) is a rare disease of largely unknown etiology. We describe a case of a 79-year-old patient with the initial diagnosis of eosinophilic gastritis with a haemorrhagic-ulcerous course and a rapid recurrence of the disease after discontinuing drug therapy.

Anamnesis And Clinical Findings: The patient stated that he had melena for several days. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0816-1247DOI Listing
July 2019
9 Reads

Eosinophilic gastroenteritis: diagnosis and clinical perspectives.

Clin Exp Gastroenterol 2019 5;12:239-253. Epub 2019 Jun 5.

Division of Gastroenterology, St. Barnabas Hospital Health System, New York, NY, 10457, USA.

Eosinophilic gastroenteritis (EGE) is a digestive disorder in children and adults that is characterized by eosinophilic infiltration in the stomach and intestine. The underlying molecular mechanisms predisposing to this disease are unknown, but it seems that hypersensitivity response plays a major role in its pathogenesis, as many patients have a history of seasonal allergies, food sensitivities, asthma, and eczema. Symptoms and clinical presentations vary, depending on the site and layer of the gastrointestinal wall infiltrated by eosinophils. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CEG.S173130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556468PMC
June 2019
8 Reads