Search our Database of Scientific Publications and Authors

I’m looking for a

    630 results match your criteria Eosinophilic Fasciitis

    1 OF 13

    A Case of Eosinophilic Fasciitis Associated with Pyoderma Gangrenosum.
    J Eur Acad Dermatol Venereol 2017 Feb 1. Epub 2017 Feb 1.
    Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, 48202.
    Eosinophilic fasciitis (EF) is a rare, systemic inflammatory disease that is characterized by symmetrical swelling and scleroderma-like indurations of the distal extremities and trunk, often accompanied by pain and eosinophilia. Rarely, muscle degeneration may occur. Histologically, EF is marked by thickened, fibrotic fascia and fascial inflammation with lymphocytes and eosinophils. Read More

    Basidiobolomycosis complicated by hydronephrosis and a perinephric abscess presenting as a hypertensive emergency in a 7-year-old boy.
    Paediatr Int Child Health 2017 Jan 23:1-4. Epub 2017 Jan 23.
    a Department of Pediatrics , Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) , Pondicherry 605006 , India.
    A 7-year-old boy presented with a chronic, indurated, tender left thigh swelling in association with a hypertensive emergency. He had a bilateral moderate degree of hydronephrosis and a left perinephric abscess, and MRI features of posterior reversible encephalopathy syndrome. Histopathological examination of the biopsy specimen demonstrated eosinophilic fasciitis with filamentous fungi. Read More

    Eosinophilic fasciitis with subjacent myositis.
    Muscle Nerve 2016 Nov 22. Epub 2016 Nov 22.
    Department of Neurology, Mayo Clinic, Jacksonville, FL, USA.
    Introduction Eosinophilic fasciitis (EF) is a rare disorder that can present with muscle symptoms that mimic other neuromuscular diseases. Methods We report a 43-year-old woman with chronic muscle aches, tightness, and stiffness with hypertrophied, well-defined muscles despite physical inactivity, and thickened skin with reduced elasticity and discoloration. Results Except for mild peripheral eosinophilia, laboratory studies, including blood count, electrolytes, paraneoplastic panel, muscle enzymes, thyroid function, and serum protein electrophoresis were normal. Read More

    A literature review of eosinophilic fasciitis with an illustrated case.
    Curr Rheumatol Rev 2016 Oct 7. Epub 2016 Oct 7.
    Clinical fellow,Neurology department, Salford Royal NHS Foundation Trust,Stott Lane, Salford, UK M6 8HD.
    Eosinophilic fasciitis (EF), a rare connective tissue disorder, was first reported by Lawrence Shulman in 1974. Since then over 300 cases have been reported worldwide. EF has variable clinical presentations and currently does not have internationally accepted diagnostic criteria. Read More

    A rare case of unilateral eosinophilic fasciitis associated with ipsilateral extragenital lichen sclerosus.
    Indian Dermatol Online J 2016 Sep-Oct;7(5):386-389
    Department of Dermatology, Indian Naval Hospital Ship Asvini, Mumbai, Maharashtra, India.
    Eosinophilic fasciitis, also known as Shulman's syndrome, is a fibrosing scleroderma-like syndrome, which is a distinct entity. A 55-year-old man, presented with progressive skin darkening, thickening, and tightening over the left lower limb since 6 months. Dermatological examination revealed a hyperpigmented indurated area on the left thigh, extending to the anterior aspect of the left leg. Read More

    Shulman disease (eosinophilic fasciitis) in X-linked agammaglobulinemia.
    Pol J Pathol 2016 Jun;67(2):183-8
    Prof. Anna Pituch-Noworolska MD, Department of Clinical Immunology, Polish-American Institute of Pediatrics, Medical College, Jagiellonian University, Wielicka 265, 30-663 Krakow, Poland, tel./fax +48 12 658 17 56, e-mail:
    X-linked agammaglobulinemia (XLA) diagnosed in the first year of life is an immunodeficiency with a life-long indication for substitution of immunoglobulins, due to lack of B lymphocytes in the periphery. The decrease of bacterial infection frequency and severity is an effect of immunoglobulin replacement. However, in the majority of patients bronchiectasis and chronic sinusitis with an overgrown mucous membrane develop despite regular substitution. Read More

    High-Dose Intravenous Pulse Methotrexate in Patients With Eosinophilic Fasciitis.
    JAMA Dermatol 2016 Nov;152(11):1262-1265
    Department of Dermatology, Radboud University Medical Centre, Nijmegen, the Netherlands.
    Importance: Eosinophilic fasciitis (EF) is a connective tissue disorder in which conventional treatment leads to disappointing results in a proportion of patients. Therefore, we investigated high-dose intravenous (IV) pulse methotrexate (MTX) as a treatment for EF.

    Objective: To examine safety and effects of monthly high-dose IV pulse MTX in EF. Read More

    Successful treatment of aplastic anemia-paroxysmal nocturnal hemoglobinuria associated with eosinophilic fasciitis with matched unrelated donor allogeneic peripheral blood stem cell transplantation.
    Clin Case Rep 2016 Aug 6;4(8):765-7. Epub 2016 Jul 6.
    Department of Leukemia The University of Texas MD Anderson Cancer Center Houston Texas USA.
    We report the first patient case of successful treatment intervention for both eosinophilic fasciitis and aplastic anemia with allogeneic peripheral blood stem cell transplantation from a matched unrelated donor after multiple immunosuppressant failure. Read More

    Eosinophilic fasciitis after parasite infection.
    Reumatologia 2016 24;54(1):38-41. Epub 2016 Mar 24.
    Centro Hospitalar Baixo Vouga, Aveiro, Portugal.
    Eosinophilic fasciitis is a systemic inflammatory disease characterized by symmetrical swelling and skin induration of the distal portions of the arms and/or legs, evolving into a scleroderma-like appearance, accompanied by peripheral blood eosinophilia. It is a rare disease with a poorly understood etiology. Corticosteroid treatment remains the standard therapy, either taken alone or in association with an immunosuppressive drug. Read More

    Development of Eosinophilic Fasciitis during Infliximab Therapy for Psoriatic Arthritis.
    Case Rep Rheumatol 2016 11;2016:7906013. Epub 2016 May 11.
    Division of Rheumatology, Department of Medicine, Medical College of Wisconsin, 9200 W. Wisconsin Avenue, Milwaukee, WI 53226, USA.
    Eosinophilic fasciitis (EF) is a rare disorder involving chronic inflammation of the fascia and connective tissue surrounding muscles, nerves, and blood vessels. While its pathogenesis is not entirely understood, this disorder is thought to be autoimmune or allergic in nature. We present here a case of a 59-year-old male who developed peripheral eosinophilia and subsequent eosinophilic fasciitis during treatment with infliximab. Read More

    Juvenile eosinophilic fasciitis: three case reports with review of the literature.
    Clin Exp Rheumatol 2016 May-Jun;34(3):527-30. Epub 2016 May 30.
    UOC Pediatria II, Reumatologia, Istituto Giannina Gaslini, Genoa, Italy.
    Objectives: Eosinophilic fasciitis is an uncommon scleroderma-like disorder characterised by induration and thickening of skin and soft tissue, usually associated with peripheral eosinophilia, poorly characterised in childhood.

    Methods: We report 3 paediatric cases of eosinophilic fasciitis showing unusual clinical and histopathological features with a review of the literature.

    Results: All cases presented progressive motility impairment started from upper limbs with no skin abnormalities. Read More

    Correspondence: The association between morphea profunda and monoclonal gammopathy: A case series.
    Dermatol Online J 2016 Mar 16;22(3). Epub 2016 Mar 16.
    University of Wisconsin.
    It is known that eosinophilic fasciitis can be associated with monoclonal gammopathy. There is clinical similarity between eosinophilic fasciitis and morphea profunda, but it is unclear whether morphea profunda might be associated with monoclonal gammopathy. The temporal quantification of gammopathy in morphea profunda has not been well characterized. Read More

    [Scleroderma-like disorders].
    Rev Med Interne 2016 Sep 3;37(9):616-24. Epub 2016 Feb 3.
    Service de médecine interne, hôpital Robert-Bisson, 4, rue Roger-Aini, 14100 Lisieux, France.
    The finding of hardening and thickening of the skin is common and can be encountered in immune mediated, metabolic, neoplastic, toxic, genetic diseases, or associated with protein deposits. The lack of Raynaud's phenomenon, capillaroscopic abnormalities, or scleroderma-specific autoantibodies should question the diagnosis of scleroderma and trigger the search for a scleroderma-like disorder, for which treatment and prognosis differ. This article gives a review of these disorders and their main characteristics. Read More

    Eosinophilic Fasciitis and Acute Encephalopathy Toxicity from Pembrolizumab Treatment of a Patient with Metastatic Melanoma.
    Cancer Immunol Res 2016 Mar 28;4(3):175-8. Epub 2016 Jan 28.
    Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
    Anti-PD-1 inhibitors have significant activity in metastatic melanoma. Responses often occur early and may be sustained. The optimal duration of treatment with these agents is unknown. Read More

    Atypical Presentation of Eosinophilic Fasciitis with Pitting Edema.
    Hawaii J Med Public Health 2015 Sep;74(9 Suppl 2):36-8
    John A. Burns School of Medicine, University of Hawai'i, Honolulu, HI (C-WC).
    Eosinophilic fasciitis (EF) is a rare condition involving inflammation of the fascia and peripheral eosinophilia of unknown etiology leading to tissue fibrosis. Clinical presentation includes peripheral eosinophilia, symmetrical skin thickening with subcutaneous tissue induration of the extremities and rashes developing acutely over a period of days to weeks. An unusual feature of EF is the presence of symmetric pitting edema presumed to be secondary to vascular leakage. Read More

    Atypical presentations of eosinophilic fasciitis.
    Indian J Dermatol Venereol Leprol 2016 Jan-Feb;82(1):47-52
    Department of Dermatology, Marmara University School of Medicine, Istanbul, Turkey.
    Eosinophilic fasciitis is an uncommon connective tissue disease that may mimic and overlap with other sclerosing disorders such as morphea and lichen sclerosus. Herein, we report four patients (two men and two women, aged 16-64 yeas) with eosinophilic fasciitis. There was overlap with both morphea and lichen sclerosus in 2 patients and with morphoea alone in 1 patient. Read More

    Severe eosinophilic fasciitis: comparison of treatment with D-penicillamine plus corticosteroids vs. corticosteroids alone.
    Scand J Rheumatol 2016 3;45(2):129-34. Epub 2015 Nov 3.
    b Jefferson Institute of Molecular Medicine and Scleroderma Center , Thomas Jefferson University , Philadelphia , PA , USA.
    Objectives: To compare the therapeutic effectiveness of corticosteroids (CS) alone vs. CS plus d-penicillamine (d-Pen) in severe eosinophilic fasciitis.

    Method: A long-term prospective non-randomized trial of d-Pen plus CS vs. Read More

    [Eosinophilic fasciitis (Shulman's disease): Diagnostic and therapeutic review].
    Rev Med Interne 2015 Nov 16;36(11):738-45. Epub 2015 Sep 16.
    Université Paris-Cité Sorbonne Paris-Diderot, 75013 Paris, France; Service de médecine interne, hôpital Lariboisière, AP-HP, 2, rue Ambroise-Paré, 75475 Paris cedex 10, France. Electronic address:
    Eosinophilic fasciitis (EF) is a rare connective tissue disease characterized by symmetrical and painful swelling with a progressive induration and thickening of the skin and soft tissues. The diagnosis of EF is often based on the association of characteristic skin or subcutaneous abnormalities and a thickened fascia with an inflammatory infiltration, mostly composed of lymphocytes and eosinophils. A peripheral eosinophilia is frequently present (60-90%) but is not mandatory for the EF diagnosis. Read More

    Scleredema Diabeticorum - A Case Report.
    Mymensingh Med J 2015 Jul;24(3):606-9
    Dr Md Nahiduzzamane Shazzad, Medical Officer, Department of Rheumatology, Bangabandhu Sheikh Mujib MedicalUniversity (BSMMU), Dhaka, Bangladesh.
    Buschke Scleredema is a rare connective tissue disorder of unknown aetiology and characterized by thickening of the dermis. It resembles systemic sclerosis, eosinophilic fasciitis and cutaneous amyloidosis. Scleredema may be associated with a history of an antecedent febrile illness, diabetes mellitus, or blood dyscrasia. Read More

    Finger stiffness or edema as presenting symptoms of eosinophilic fasciitis.
    Rheumatol Int 2015 Oct 7;35(10):1769-72. Epub 2015 Aug 7.
    Department of General Medicine, Chiba University Hospital, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba, 260-8677, Japan.
    To investigate the clinical features and finger symptoms of eosinophilic fasciitis (EF), we reviewed five patients with EF. The chief complaint was pain, edema and/or stiffness of the extremities. The distal extremities were affected in all patients, and there was also proximal involvement in one patient. Read More

    Eosinophilia in Rheumatologic/Vascular Disorders.
    Immunol Allergy Clin North Am 2015 Aug 17;35(3):453-76. Epub 2015 Jun 17.
    Department of Rheumatic and Immunologic Diseases, Center for Vasculitis Care and Research, Cleveland Clinic, 9500 Euclid Avenue, A50, Cleveland, OH 44195, USA. Electronic address:
    Peripheral and tissue eosinophilia can be a prominent feature of several unique rheumatologic and vascular diseases. These diseases span a wide range of clinical features, histologic findings, therapeutic approaches, and outcomes. Despite the rare nature of these entities--which makes large-scale studies challenging--knowledge has continued to grow regarding their epidemiology, pathophysiology, and management. Read More

    Efficacy of Tocilizumab in the treatment of Eosinophilic fasciitis: Report of one case.
    Joint Bone Spine 2015 Dec 7;82(6):460-1. Epub 2015 Jul 7.
    Clinical immunology and osteoarticular diseases therapeutic unit, Lapeyronie university hospital, 371, avenue du Doyen-Gaston-Giraud, 34295 Montpellier, France. Electronic address:
    A 43-year-old man was diagnosed with an Eosinophilic fasciitis with cutaneous and articular involvement. The patient experienced an early response with high-dose corticosteroids achieving a global remission of disease. Nevertheless, during the steroids tapering phase, he presented a new flare and subsequently developed a corticosteroid refractory disease. Read More

    Eosinophilic fasciitis associated with myositis.
    Case Rep Dermatol 2015 Jan-Apr;7(1):79-83. Epub 2015 Apr 30.
    Department of Dermatology, Gifu University Graduate School of Medicine, Gifu, Japan.
    Eosinophilic fasciitis is clinically characterized by symmetrical scleroderma-like indurations of the skin with pain. The histological features are fascial inflammation with lymphocytes and eosinophils as well as thickened and fibrotic fascia. Lymphocytic infiltration and degeneration of the underlying muscle are rarely observed. Read More

    [Eosinophilic fasciitis].
    Postepy Hig Med Dosw (Online) 2015 Jan 2;69:488-95. Epub 2015 Jan 2.
    Katedra i Klinika Reumatologii i Chorób Wewnętrznych Uniwersytetu Medycznego w Poznaniu.
    Eosinophilic fasciitis is a rare connective tissue disease with unclear etiology and pathogenesis. It is classified as a scleroderma-like syndrome. The disease is characterized by fibrosis of the skin and subcutaneous tissues with significant thickening of fascia. Read More

    Extracorporeal photopheresis for the treatment of autoimmune diseases.
    Transfus Apher Sci 2015 Apr 16;52(2):171-82. Epub 2015 Feb 16.
    Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
    The immune system is tasked with the unique challenge of recognizing foreign pathogens and damaged cells while at the same time preserving and protecting the integrity of "self". When this process fails, severe consequences including cancer and autoimmunity are the end result. Current therapies aimed at treating autoimmune disorders result in generalized immunosuppression and place the patient at increased risk for infection and malignancy. Read More

    Eosinophilic Skin Diseases: A Comprehensive Review.
    Clin Rev Allergy Immunol 2016 Apr;50(2):189-213
    Department of Dermatology, The Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha, Hunan, 410011, China.
    Eosinophilic skin diseases, commonly termed as eosinophilic dermatoses, refer to a broad spectrum of skin diseases characterized by eosinophil infiltration and/or degranulation in skin lesions, with or without blood eosinophilia. The majority of eosinophilic dermatoses lie in the allergy-related group, including allergic drug eruption, urticaria, allergic contact dermatitis, atopic dermatitis, and eczema. Parasitic infestations, arthropod bites, and autoimmune blistering skin diseases such as bullous pemphigoid, are also common. Read More

    Forearm compartment syndrome as a result of eosinophilic fasciitis: case report.
    J Hand Surg Am 2015 Apr 4;40(4):707-10. Epub 2015 Mar 4.
    Department of Surgery, Hamilton General Hospital, Hamilton, Ontario, Canada; Department of Surgery, Sunnybrook Health Sciences Center, Toronto, Ontario, Canada; Department of Pathology, Sunnybrook Health Sciences Center, Toronto, Ontario, Canada.
    Eosinophilic fasciitis is an uncommon scleroderma-like connective tissue disease, usually characterized by symmetrical and painful swelling and induration of the skin and thickened fascia infiltrated with lymphocytes and eosinophils. A middle-aged woman with follicular lymphoma being treated with chemotherapy presented with acute onset atraumatic forearm swelling and severe pain. The history, physical examination, and pressure measurements were consistent with compartment syndrome. Read More

    Eosinophilic fasciitis: typical abnormalities, variants and differential diagnosis of fasciae abnormalities using MR imaging.
    Diagn Interv Imaging 2015 Apr 4;96(4):341-8. Epub 2015 Mar 4.
    Service de radiologie, Département d'imagerie musculo-squelettique, Cliniques Universitaires Saint-Luc, avenue Hippocrate 10-1200, Brussels, Belgium.
    Eosinophilic fasciitis is a rare condition. It is generally limited to the distal parts of the arms and legs. MRI is the ideal imaging modality for diagnosing and monitoring this condition. Read More

    Chronic graft-versus-host disease presenting as eosinophilic fasciitis: therapeutic challenges and an additional case.
    J Clin Rheumatol 2015 Mar;21(2):86-94
    From the *Wooster Family Health Center, Wooster; †Orthopedic and Rheumatologic Institute; ‡Hematology and Oncology, Cleveland Clinic Main Campus, Cleveland, OH; and §Rheumatology Sutter Medical Group, Sutter Medical Foundation, Sacramento, CA.
    Chronic graft-versus-host disease (cGVHD) is one of the main late complications of allogeneic hematopoietic stem cell transplant and a major contributor to the mortality and morbidity in surviving recipients. Skin is the most common involved organ in cGVHD and may mimic a wide spectrum of dermatological conditions in its clinical and histopathologic manifestations. Some of the commonly simulated diseases are scleroderma, morphea, and lichen sclerosus. Read More

    Necrotizing fasciitis and its mimics: what radiologists need to know.
    AJR Am J Roentgenol 2015 Jan;204(1):128-39
    1 Department of Radiology, Stony Brook University Medical Center, HSC Level 4, Rm 120, East Loop Rd, Stony Brook, NY 11794.
    Objective: The purpose of this article is to review the imaging features of necrotizing fasciitis and its potential mimics. Key imaging features are emphasized to enable accurate and efficient interpretation of variables that are essential in appropriate management.

    Conclusion: Necrotizing fasciitis is a medical emergency with potential lethal outcome. Read More

    Eosinophilic fasciitis: clinical characteristics and response to methotrexate.
    Int J Rheum Dis 2015 Jan 20;18(1):91-8. Epub 2014 Dec 20.
    Department of Rheumatology, Mayo Clinic, Jacksonville, Florida, USA.
    Aim: To describe our experience with 16 patients with eosinophilic fasciitis (EF) treated in our clinic over 14 years.

    Methods: We retrospectively reviewed the charts of all patients with biopsy-proven EF. We collected data regarding demographics, clinical presentations, possible triggers, labs, imaging, treatment and response to therapy on follow-up. Read More

    Association of eosinophilic fasciitis with morphea.
    Folia Med (Plovdiv) 2014 Jul-Sep;56(3):220-4
    Eosinophilic fasciitis is a rare inflammatory disease of unknown etiology, described for the first time by Shulman in 1974. The disease presents with induration of the skin, connective tissue and the underlying muscle fascia, sometimes accompanied by myalgia, most commonly in the lower extremities. Unlike scleroderma, it presents with absence of visceral organ involvement and Raynaud's phenomenon. Read More

    [Eosinophilic fasciitis, morphea and vitiligo in a single patient].
    Ann Dermatol Venereol 2014 Oct 7;141(10):598-602. Epub 2014 Aug 7.
    Service de dermatologie, CHU Hassan II, BP 1835, Atlass, Fès, Maroc.
    Background: Fasciitis with eosinophilia (FE), or Shulman syndrome, is a rare disease of unknown origin for which the nosological profile has not been clearly defined. It is clinically characterised by oedema and induration of the limbs with hypereosinophilia. It may be associated with morphea, in which case it carries a poor prognosis, or other diseases, particularly autoimmune conditions. Read More

    The use of an elevated aldolase in diagnosing and managing eosinophilic fasciitis.
    Clin Rheumatol 2015 Aug 24;34(8):1481-4. Epub 2014 Sep 24.
    Beth Israel Deaconess Hospital, Boston, MA, USA.
    Eosinophilic fasciitis (EF) is a rare localized fibrosing disorder of the fascia whose diagnosis is often suspected based on clinical findings and laboratory values. These lab abnormalities can be transient in early disease and may not always be present. We have reviewed a case series of patients to assess the utility of the various laboratory abnormalities in diagnosing EF. Read More

    1 OF 13